ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	5.60561300
2	cilium or flagellum-dependent cell motility (GO:0001539)	5.47790763
3	cilium movement (GO:0003341)	5.33879750
4	epithelial cilium movement (GO:0003351)	5.33555549
5	motile cilium assembly (GO:0044458)	5.00639823
6	sperm motility (GO:0030317)	4.88278074
7	protein polyglutamylation (GO:0018095)	4.81475477
8	acrosome reaction (GO:0007340)	4.58056303
9	regulation of cilium movement (GO:0003352)	4.45891385
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.28479996
11	axoneme assembly (GO:0035082)	4.19308904
12	microtubule depolymerization (GO:0007019)	4.14768231
13	postsynaptic membrane organization (GO:0001941)	4.10259232
14	response to pheromone (GO:0019236)	3.97885213
15	behavioral response to nicotine (GO:0035095)	3.74342896
16	spermatid development (GO:0007286)	3.63677270
17	microtubule polymerization or depolymerization (GO:0031109)	3.61527074
18	nonmotile primary cilium assembly (GO:0035058)	3.61181717
19	cilium organization (GO:0044782)	3.54540538
20	piRNA metabolic process (GO:0034587)	3.53401478
21	cilium assembly (GO:0042384)	3.50842973
22	cellular ketone body metabolic process (GO:0046950)	3.44741609
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.43564166
24	multicellular organism reproduction (GO:0032504)	3.39436595
25	positive regulation of meiosis (GO:0045836)	3.38767187
26	intraciliary transport (GO:0042073)	3.32397881
27	response to nitrosative stress (GO:0051409)	3.22510460
28	regulation of microtubule-based movement (GO:0060632)	3.20162308
29	calcium ion-dependent exocytosis (GO:0017156)	3.19650530
30	sperm-egg recognition (GO:0035036)	3.19131744
31	presynaptic membrane assembly (GO:0097105)	3.18413007
32	regulation of meiosis I (GO:0060631)	3.18044152
33	positive regulation of meiotic cell cycle (GO:0051446)	3.17063664
34	male meiosis (GO:0007140)	3.16730041
35	retinal cone cell development (GO:0046549)	3.14469387
36	detection of light stimulus involved in visual perception (GO:0050908)	3.14370635
37	detection of light stimulus involved in sensory perception (GO:0050962)	3.14370635
38	transmission of nerve impulse (GO:0019226)	3.13781719
39	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.11427682
40	synapsis (GO:0007129)	3.10422806
41	regulation of neurotransmitter uptake (GO:0051580)	3.08832379
42	cilium morphogenesis (GO:0060271)	3.08703276
43	fusion of sperm to egg plasma membrane (GO:0007342)	3.08179415
44	cerebral cortex radially oriented cell migration (GO:0021799)	3.06263412
45	ketone body metabolic process (GO:1902224)	3.02436555
46	auditory behavior (GO:0031223)	2.97341387
47	primary amino compound metabolic process (GO:1901160)	2.92935295
48	tongue development (GO:0043586)	2.84843965
49	cellular component assembly involved in morphogenesis (GO:0010927)	2.79496883
50	DNA methylation involved in gamete generation (GO:0043046)	2.79350841
51	negative regulation of astrocyte differentiation (GO:0048712)	2.78772377
52	photoreceptor cell maintenance (GO:0045494)	2.77621105
53	prepulse inhibition (GO:0060134)	2.76367241
54	sperm capacitation (GO:0048240)	2.76028232
55	male meiosis I (GO:0007141)	2.75091677
56	centriole replication (GO:0007099)	2.74303296
57	neuron cell-cell adhesion (GO:0007158)	2.74127450
58	protein localization to synapse (GO:0035418)	2.70765489
59	mechanosensory behavior (GO:0007638)	2.70500512
60	serotonin metabolic process (GO:0042428)	2.69016437
61	male gamete generation (GO:0048232)	2.68091216
62	gamma-aminobutyric acid transport (GO:0015812)	2.67881032
63	spermatogenesis (GO:0007283)	2.67748805
64	left/right axis specification (GO:0070986)	2.66300909
65	retinal rod cell development (GO:0046548)	2.66238130
66	presynaptic membrane organization (GO:0097090)	2.65677414
67	binding of sperm to zona pellucida (GO:0007339)	2.64979948
68	microtubule bundle formation (GO:0001578)	2.63319463
69	single strand break repair (GO:0000012)	2.61041200
70	one-carbon compound transport (GO:0019755)	2.60965537
71	artery development (GO:0060840)	2.60643318
72	spermatid nucleus differentiation (GO:0007289)	2.59068521
73	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.56953012
74	plasma membrane fusion (GO:0045026)	2.56903380
75	auditory receptor cell stereocilium organization (GO:0060088)	2.56072560
76	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.53437514
77	cell-cell recognition (GO:0009988)	2.52313719
78	reproduction (GO:0000003)	2.51919930
79	membrane depolarization during action potential (GO:0086010)	2.51811811
80	centriole assembly (GO:0098534)	2.51567499
81	gamete generation (GO:0007276)	2.51309804
82	neuromuscular synaptic transmission (GO:0007274)	2.49059232
83	response to auditory stimulus (GO:0010996)	2.48371444
84	outer ear morphogenesis (GO:0042473)	2.47648721
85	single fertilization (GO:0007338)	2.46041657
86	chromosome organization involved in meiosis (GO:0070192)	2.45991532
87	behavioral response to cocaine (GO:0048148)	2.45593859
88	inner ear receptor stereocilium organization (GO:0060122)	2.45015586
89	neurotransmitter catabolic process (GO:0042135)	2.44707654
90	ventricular system development (GO:0021591)	2.44684488
91	microtubule severing (GO:0051013)	2.43897547
92	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.43256781
93	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.43256781
94	smoothened signaling pathway (GO:0007224)	2.39465761
95	glycerophospholipid catabolic process (GO:0046475)	2.36741584
96	fertilization (GO:0009566)	2.35643813
97	reflex (GO:0060004)	2.32496632
98	coenzyme catabolic process (GO:0009109)	2.31920487
99	neuronal action potential (GO:0019228)	2.31110679
100	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.29582515

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.78353712
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.34288221
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.23467344
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01148616
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.90123666
6	VDR_22108803_ChIP-Seq_LS180_Human	2.89848171
7	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.77617589
8	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.50802762
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.31301615
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21462996
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.15840058
12	FUS_26573619_Chip-Seq_HEK293_Human	2.04842990
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.99706588
14	* ER_23166858_ChIP-Seq_MCF-7_Human	1.91558375
15	P300_19829295_ChIP-Seq_ESCs_Human	1.88480703
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86542113
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.84675051
18	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71621387
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70293916
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69422576
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.69248644
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69248644
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67444356
24	STAT3_23295773_ChIP-Seq_U87_Human	1.63192012
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62495198
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.62495198
27	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.61019702
28	DROSHA_22980978_ChIP-Seq_HELA_Human	1.56296903
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52560180
30	AR_25329375_ChIP-Seq_VCAP_Human	1.51934804
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48964026
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.48511221
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.47679937
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.47292891
35	EWS_26573619_Chip-Seq_HEK293_Human	1.45496631
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43155151
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42755956
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42025036
39	RUNX2_22187159_ChIP-Seq_PCA_Human	1.39919663
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39821427
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39278092
42	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.38955482
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37152504
44	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36552988
45	TCF4_23295773_ChIP-Seq_U87_Human	1.35460095
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.34153788
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34107752
48	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32522229
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.32466679
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.31464569
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30463634
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29784620
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25776641
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.24466692
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23831142
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23831142
57	NCOR_22424771_ChIP-Seq_293T_Human	1.22147589
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21356777
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.21122710
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21037774
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21037774
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.21037047
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20872375
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20554417
65	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.20508895
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.20379092
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19375863
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.19049160
69	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.19032690
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18941391
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18576799
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17914966
73	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16334975
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.16063828
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15848304
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.15490685
77	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.13652889
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11507083
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11052242
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09544086
81	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.09492600
82	TBL1_22424771_ChIP-Seq_293T_Human	1.07548334
83	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.07424485
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07106631
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06934394
86	TP53_22573176_ChIP-Seq_HFKS_Human	1.06868534
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05883856
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04764322
89	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.04561395
90	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04456272
91	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.02601077
92	ERA_21632823_ChIP-Seq_H3396_Human	1.02521577
93	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.02297616
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01625740
95	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00470099
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99991851
97	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.99392727
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99123682
99	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.98867280
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98468206

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.51834486
2	MP0000566_synostosis	3.28074467
3	MP0001984_abnormal_olfaction	2.65589663
4	MP0006292_abnormal_olfactory_placode	2.61101938
5	MP0009046_muscle_twitch	2.51214998
6	MP0001968_abnormal_touch/_nociception	2.47199135
7	MP0003136_yellow_coat_color	2.35312657
8	MP0005551_abnormal_eye_electrophysiolog	2.30553255
9	MP0002736_abnormal_nociception_after	2.20669000
10	MP0001486_abnormal_startle_reflex	2.04313935
11	MP0009745_abnormal_behavioral_response	2.03494107
12	MP0003698_abnormal_male_reproductive	2.01703188
13	MP0008789_abnormal_olfactory_epithelium	1.95351808
14	MP0005646_abnormal_pituitary_gland	1.94348334
15	MP0002735_abnormal_chemical_nociception	1.88598611
16	MP0001529_abnormal_vocalization	1.86849873
17	MP0002272_abnormal_nervous_system	1.84121778
18	MP0002572_abnormal_emotion/affect_behav	1.82544287
19	MP0003635_abnormal_synaptic_transmissio	1.81011545
20	MP0004885_abnormal_endolymph	1.80460512
21	MP0002234_abnormal_pharynx_morphology	1.79462157
22	MP0001929_abnormal_gametogenesis	1.78300894
23	MP0002734_abnormal_mechanical_nocicepti	1.78166499
24	MP0004270_analgesia	1.76282027
25	MP0004859_abnormal_synaptic_plasticity	1.76094462
26	MP0006276_abnormal_autonomic_nervous	1.76008502
27	MP0003011_delayed_dark_adaptation	1.75270140
28	MP0005253_abnormal_eye_physiology	1.71089677
29	MP0002653_abnormal_ependyma_morphology	1.70233507
30	MP0005423_abnormal_somatic_nervous	1.69570976
31	MP0002064_seizures	1.67410521
32	MP0005394_taste/olfaction_phenotype	1.65627511
33	MP0005499_abnormal_olfactory_system	1.65627511
34	MP0006072_abnormal_retinal_apoptosis	1.64374939
35	MP0002638_abnormal_pupillary_reflex	1.61659269
36	MP0004742_abnormal_vestibular_system	1.60272031
37	MP0002063_abnormal_learning/memory/cond	1.59666207
38	MP0001970_abnormal_pain_threshold	1.59132371
39	MP0001501_abnormal_sleep_pattern	1.56972182
40	MP0002557_abnormal_social/conspecific_i	1.56905178
41	MP0002067_abnormal_sensory_capabilities	1.55240774
42	MP0002733_abnormal_thermal_nociception	1.55087912
43	MP0000631_abnormal_neuroendocrine_gland	1.49449855
44	MP0001485_abnormal_pinna_reflex	1.47029400
45	MP0000026_abnormal_inner_ear	1.40870993
46	MP0008877_abnormal_DNA_methylation	1.40849411
47	MP0005377_hearing/vestibular/ear_phenot	1.37569430
48	MP0003878_abnormal_ear_physiology	1.37569430
49	MP0001905_abnormal_dopamine_level	1.35281026
50	MP0001502_abnormal_circadian_rhythm	1.34639166
51	MP0000569_abnormal_digit_pigmentation	1.31648942
52	MP0002249_abnormal_larynx_morphology	1.30693132
53	MP0003880_abnormal_central_pattern	1.30612058
54	MP0008875_abnormal_xenobiotic_pharmacok	1.22939443
55	MP0002938_white_spotting	1.22118396
56	MP0001963_abnormal_hearing_physiology	1.19192883
57	MP0003283_abnormal_digestive_organ	1.18511064
58	MP0002210_abnormal_sex_determination	1.18212988
59	MP0000778_abnormal_nervous_system	1.17787782
60	MP0009780_abnormal_chondrocyte_physiolo	1.16714251
61	MP0003718_maternal_effect	1.15963041
62	MP0004142_abnormal_muscle_tone	1.14279774
63	MP0002229_neurodegeneration	1.14225004
64	MP0008872_abnormal_physiological_respon	1.10907600
65	MP0001440_abnormal_grooming_behavior	1.10732277
66	MP0000678_abnormal_parathyroid_gland	1.08110604
67	MP0005174_abnormal_tail_pigmentation	1.07878394
68	MP0000427_abnormal_hair_cycle	1.05331948
69	MP0004043_abnormal_pH_regulation	1.04349919
70	MP0002161_abnormal_fertility/fecundity	1.03771926
71	MP0000653_abnormal_sex_gland	1.03126642
72	MP0002282_abnormal_trachea_morphology	1.03106457
73	MP0004133_heterotaxia	1.01811999
74	MP0001145_abnormal_male_reproductive	1.00905065
75	MP0005248_abnormal_Harderian_gland	1.00483491
76	MP0002882_abnormal_neuron_morphology	0.97558760
77	MP0002822_catalepsy	0.97439487
78	MP0005645_abnormal_hypothalamus_physiol	0.94834821
79	MP0005670_abnormal_white_adipose	0.92460306
80	MP0005386_behavior/neurological_phenoty	0.91869887
81	MP0004924_abnormal_behavior	0.91869887
82	MP0003938_abnormal_ear_development	0.91804169
83	MP0004147_increased_porphyrin_level	0.91350650
84	MP0003633_abnormal_nervous_system	0.91127802
85	MP0000955_abnormal_spinal_cord	0.90699005
86	MP0002752_abnormal_somatic_nervous	0.90676766
87	MP0003122_maternal_imprinting	0.89859124
88	MP0005187_abnormal_penis_morphology	0.87920685
89	MP0000049_abnormal_middle_ear	0.87038120
90	MP0002102_abnormal_ear_morphology	0.85805071
91	MP0003137_abnormal_impulse_conducting	0.85519289
92	MP0008569_lethality_at_weaning	0.83172421
93	MP0003119_abnormal_digestive_system	0.82520715
94	MP0005195_abnormal_posterior_eye	0.82271910
95	MP0002184_abnormal_innervation	0.80434726
96	MP0002066_abnormal_motor_capabilities/c	0.79980993
97	MP0003879_abnormal_hair_cell	0.79949861
98	MP0000383_abnormal_hair_follicle	0.79826848
99	MP0005391_vision/eye_phenotype	0.78862233
100	MP0000681_abnormal_thyroid_gland	0.76937369

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	5.01370422
2	Absent/shortened dynein arms (HP:0200106)	4.96719422
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.96719422
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.78062736
5	Abnormal respiratory motile cilium physiology (HP:0012261)	4.73419305
6	Abnormal respiratory motile cilium morphology (HP:0005938)	4.62152335
7	Abnormal respiratory epithelium morphology (HP:0012253)	4.62152335
8	Retinal dysplasia (HP:0007973)	4.54308833
9	Rhinitis (HP:0012384)	4.12607677
10	Pancreatic fibrosis (HP:0100732)	3.84438960
11	Type II lissencephaly (HP:0007260)	3.82418826
12	True hermaphroditism (HP:0010459)	3.74435158
13	Molar tooth sign on MRI (HP:0002419)	3.44032702
14	Abnormality of midbrain morphology (HP:0002418)	3.44032702
15	Medial flaring of the eyebrow (HP:0010747)	3.43701623
16	Pancreatic cysts (HP:0001737)	3.39133837
17	Nephronophthisis (HP:0000090)	3.30156721
18	Gait imbalance (HP:0002141)	3.25416828
19	Progressive cerebellar ataxia (HP:0002073)	3.24810014
20	Chronic hepatic failure (HP:0100626)	3.21567723
21	Congenital stationary night blindness (HP:0007642)	3.19804938
22	Congenital primary aphakia (HP:0007707)	3.04387046
23	Attenuation of retinal blood vessels (HP:0007843)	3.01670460
24	Cerebellar dysplasia (HP:0007033)	2.73906272
25	Nephrogenic diabetes insipidus (HP:0009806)	2.68921538
26	Abnormality of the renal medulla (HP:0100957)	2.68055706
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.59437849
28	Postaxial foot polydactyly (HP:0001830)	2.59251313
29	Cystic liver disease (HP:0006706)	2.53816440
30	Hemiparesis (HP:0001269)	2.53276486
31	Occipital encephalocele (HP:0002085)	2.53090269
32	Genital tract atresia (HP:0001827)	2.47538444
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.41040172
34	Sclerocornea (HP:0000647)	2.40050969
35	Focal motor seizures (HP:0011153)	2.39063278
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.37755538
37	Vaginal atresia (HP:0000148)	2.34500920
38	Bronchiectasis (HP:0002110)	2.32839687
39	Large for gestational age (HP:0001520)	2.26980232
40	Abnormality of macular pigmentation (HP:0008002)	2.26602970
41	Gaze-evoked nystagmus (HP:0000640)	2.24355132
42	Tubulointerstitial nephritis (HP:0001970)	2.23195676
43	Poor coordination (HP:0002370)	2.22784194
44	Postaxial hand polydactyly (HP:0001162)	2.21959753
45	Male pseudohermaphroditism (HP:0000037)	2.20353725
46	Severe visual impairment (HP:0001141)	2.18931057
47	Hyperventilation (HP:0002883)	2.15089056
48	Renal dysplasia (HP:0000110)	2.13031125
49	Genetic anticipation (HP:0003743)	2.11625793
50	Lissencephaly (HP:0001339)	2.09132193
51	Abnormality of the aortic arch (HP:0012303)	2.08739642
52	Congenital hepatic fibrosis (HP:0002612)	2.06729139
53	Infertility (HP:0000789)	2.05566173
54	Broad-based gait (HP:0002136)	2.02858927
55	Keratoconus (HP:0000563)	2.02411747
56	Increased corneal curvature (HP:0100692)	2.02411747
57	Pachygyria (HP:0001302)	2.00387421
58	Abnormal drinking behavior (HP:0030082)	1.99907584
59	Polydipsia (HP:0001959)	1.99907584
60	Anencephaly (HP:0002323)	1.97962069
61	Abnormality of the renal cortex (HP:0011035)	1.97693202
62	Chronic bronchitis (HP:0004469)	1.95520117
63	Abnormality of the labia minora (HP:0012880)	1.95491288
64	Atonic seizures (HP:0010819)	1.94224745
65	Myokymia (HP:0002411)	1.93019492
66	Decreased central vision (HP:0007663)	1.89627365
67	Progressive microcephaly (HP:0000253)	1.89554560
68	Retinitis pigmentosa (HP:0000510)	1.89341977
69	Dyskinesia (HP:0100660)	1.87477437
70	Rib fusion (HP:0000902)	1.83947935
71	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.83165073
72	Dysdiadochokinesis (HP:0002075)	1.82917671
73	Abnormality of alanine metabolism (HP:0010916)	1.80238989
74	Hyperalaninemia (HP:0003348)	1.80238989
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.80238989
76	Polyphagia (HP:0002591)	1.79952083
77	Febrile seizures (HP:0002373)	1.78067512
78	Broad distal phalanx of finger (HP:0009836)	1.75752668
79	Aplasia/Hypoplasia of the lens (HP:0008063)	1.72977860
80	Preaxial hand polydactyly (HP:0001177)	1.71985085
81	Optic nerve hypoplasia (HP:0000609)	1.71939081
82	Specific learning disability (HP:0001328)	1.70848197
83	Epileptic encephalopathy (HP:0200134)	1.70766327
84	Abnormality of the fovea (HP:0000493)	1.70682746
85	Aganglionic megacolon (HP:0002251)	1.68740311
86	Furrowed tongue (HP:0000221)	1.68152068
87	Multicystic kidney dysplasia (HP:0000003)	1.66627665
88	Broad foot (HP:0001769)	1.64459638
89	Prominent nasal bridge (HP:0000426)	1.64035386
90	Focal seizures (HP:0007359)	1.63717058
91	Action tremor (HP:0002345)	1.63514640
92	Tubular atrophy (HP:0000092)	1.63010386
93	Congenital sensorineural hearing impairment (HP:0008527)	1.62696605
94	Abolished electroretinogram (ERG) (HP:0000550)	1.62643122
95	Hypoplastic ischia (HP:0003175)	1.61832801
96	Abnormality of the ischium (HP:0003174)	1.61131221
97	Abnormality of the diencephalon (HP:0010662)	1.61015959
98	Polyuria (HP:0000103)	1.58913793
99	Abnormal eating behavior (HP:0100738)	1.58834088
100	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.56131628

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.63594778
2	FRK	3.60859413
3	PINK1	3.43337578
4	INSRR	3.12074693
5	BMPR1B	2.66240691
6	MAPK15	2.59470912
7	NTRK3	2.46789535
8	ADRBK2	2.44134506
9	WNK4	2.29502143
10	PNCK	2.17410046
11	CASK	2.13760962
12	GRK1	2.10022528
13	PLK4	2.07426620
14	PRKD3	1.97774032
15	BRSK2	1.75611898
16	PHKG2	1.64172750
17	PHKG1	1.64172750
18	MARK1	1.62266915
19	MAPK13	1.52461753
20	FGFR2	1.52226028
21	TESK1	1.48328628
22	ZAK	1.48063497
23	DAPK2	1.38347816
24	MAP3K4	1.38020145
25	ACVR1B	1.33220118
26	EPHA4	1.31558351
27	PLK2	1.28175549
28	WNK3	1.27744365
29	BCKDK	1.23242560
30	NME1	1.16544023
31	TGFBR1	1.13243514
32	LATS1	1.11448985
33	UHMK1	1.11099991
34	WEE1	1.06934157
35	PKN1	1.06381309
36	DYRK2	1.06165829
37	STK38L	1.02886545
38	MAPKAPK5	1.02880754
39	SGK223	1.01274059
40	SGK494	1.01274059
41	MAP3K2	0.96477270
42	CSNK1G1	0.96410622
43	PRKCG	0.95907964
44	CSNK1G2	0.94920419
45	PTK2B	0.94704389
46	CDK19	0.92716713
47	BRSK1	0.91469561
48	CSNK1G3	0.90654834
49	NTRK2	0.89035127
50	CSNK1A1L	0.88450101
51	STK39	0.87696793
52	TLK1	0.87610167
53	WNK1	0.86263867
54	NEK2	0.85490984
55	TNK2	0.84025769
56	EPHB2	0.81446507
57	PRKCE	0.81427639
58	SIK2	0.78558722
59	MAP2K7	0.76798284
60	STK38	0.71272820
61	CDK8	0.67870097
62	CAMK2A	0.67409926
63	MAP3K9	0.64753746
64	GRK5	0.64714947
65	MINK1	0.58865933
66	TAOK3	0.57034668
67	OXSR1	0.56235273
68	PAK3	0.56008644
69	LIMK1	0.55213781
70	VRK1	0.54670252
71	CDK3	0.52770964
72	CAMK1G	0.50841266
73	SGK1	0.50511019
74	CDK5	0.49856447
75	SGK2	0.49589716
76	CAMK2B	0.48564309
77	PRKG1	0.47741784
78	ADRBK1	0.47322878
79	DDR2	0.47210388
80	MST4	0.45570170
81	CAMK2D	0.44993566
82	BCR	0.43856562
83	CSNK1A1	0.43218499
84	RPS6KA5	0.42066117
85	PLK1	0.41897615
86	STK3	0.40464150
87	ERBB2	0.38374011
88	TRIM28	0.36702863
89	TNIK	0.36547838
90	MAPKAPK3	0.35397856
91	KSR2	0.35382213
92	FER	0.35259718
93	MKNK2	0.34921014
94	PRKACA	0.34073509
95	CAMK2G	0.33528512
96	MAP3K7	0.33084885
97	PRKCH	0.32451990
98	CHEK2	0.32180284
99	PAK6	0.30652387
100	CAMKK2	0.30377657

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.53337476
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.97018329
3	Nicotine addiction_Homo sapiens_hsa05033	2.65221981
4	Butanoate metabolism_Homo sapiens_hsa00650	2.54874420
5	Phototransduction_Homo sapiens_hsa04744	2.19600543
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.07507864
7	Olfactory transduction_Homo sapiens_hsa04740	2.05327986
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01976297
9	Taste transduction_Homo sapiens_hsa04742	1.84800202
10	Morphine addiction_Homo sapiens_hsa05032	1.84508730
11	GABAergic synapse_Homo sapiens_hsa04727	1.79232953
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77564618
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.74339186
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.72396399
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71365450
16	Insulin secretion_Homo sapiens_hsa04911	1.68845290
17	Circadian entrainment_Homo sapiens_hsa04713	1.54883776
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52333322
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.50399888
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.48321972
21	ABC transporters_Homo sapiens_hsa02010	1.48047468
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.46958661
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.46510260
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.45341913
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36904314
26	Salivary secretion_Homo sapiens_hsa04970	1.31217122
27	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.27285765
28	Regulation of autophagy_Homo sapiens_hsa04140	1.26124327
29	Folate biosynthesis_Homo sapiens_hsa00790	1.25551968
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.24852934
31	Propanoate metabolism_Homo sapiens_hsa00640	1.22394365
32	Huntingtons disease_Homo sapiens_hsa05016	1.21718629
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.19453595
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.17480222
35	Cocaine addiction_Homo sapiens_hsa05030	1.15368330
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12448618
37	Peroxisome_Homo sapiens_hsa04146	1.11694499
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11639694
39	Amphetamine addiction_Homo sapiens_hsa05031	1.11337636
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10351583
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.10265425
42	Circadian rhythm_Homo sapiens_hsa04710	1.09757178
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09060085
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.08854793
45	Calcium signaling pathway_Homo sapiens_hsa04020	1.06549900
46	Serotonergic synapse_Homo sapiens_hsa04726	1.02767753
47	Parkinsons disease_Homo sapiens_hsa05012	1.02221063
48	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01246521
49	Homologous recombination_Homo sapiens_hsa03440	1.00873115
50	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00686593
51	Retinol metabolism_Homo sapiens_hsa00830	1.00445634
52	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00233654
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99167282
54	Dopaminergic synapse_Homo sapiens_hsa04728	0.98746835
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98651341
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94744068
57	Histidine metabolism_Homo sapiens_hsa00340	0.94451254
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94087523
59	Caffeine metabolism_Homo sapiens_hsa00232	0.93838998
60	Gastric acid secretion_Homo sapiens_hsa04971	0.93100902
61	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.90139132
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.87685114
63	Basal transcription factors_Homo sapiens_hsa03022	0.83552171
64	Sulfur relay system_Homo sapiens_hsa04122	0.83247870
65	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.82297903
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80577022
67	Protein export_Homo sapiens_hsa03060	0.80365785
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78256356
69	RNA polymerase_Homo sapiens_hsa03020	0.77872345
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.76894980
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.76001117
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.74821005
73	Alzheimers disease_Homo sapiens_hsa05010	0.70568359
74	Oocyte meiosis_Homo sapiens_hsa04114	0.69980035
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.68661429
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68306602
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.66727973
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.66658616
79	Cholinergic synapse_Homo sapiens_hsa04725	0.66627123
80	Purine metabolism_Homo sapiens_hsa00230	0.66235606
81	Fatty acid degradation_Homo sapiens_hsa00071	0.65086684
82	Metabolic pathways_Homo sapiens_hsa01100	0.64564405
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.64415882
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.64010291
85	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63780122
86	Glutathione metabolism_Homo sapiens_hsa00480	0.61292046
87	Renin secretion_Homo sapiens_hsa04924	0.58408589
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58063655
89	Mineral absorption_Homo sapiens_hsa04978	0.54445298
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54051152
91	Pancreatic secretion_Homo sapiens_hsa04972	0.53714298
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52045515
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51934767
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51070538
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50618235
96	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.49387593
97	Long-term depression_Homo sapiens_hsa04730	0.47590176
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46167063
99	Gap junction_Homo sapiens_hsa04540	0.46095086
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45865718

FAM182B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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