ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	9.14187201
2	ventricular system development (GO:0021591)	8.75212569
3	intraciliary transport (GO:0042073)	8.08581279
4	regulation of cilium movement (GO:0003352)	7.24545933
5	cilium organization (GO:0044782)	6.84435647
6	cilium assembly (GO:0042384)	6.60070163
7	left/right axis specification (GO:0070986)	6.41271017
8	microtubule bundle formation (GO:0001578)	5.90326213
9	cilium morphogenesis (GO:0060271)	5.56828936
10	centriole assembly (GO:0098534)	5.52118899
11	nucleoside diphosphate phosphorylation (GO:0006165)	5.44414564
12	protein localization to cilium (GO:0061512)	5.39658986
13	microtubule-based movement (GO:0007018)	5.32139865
14	cellular component assembly involved in morphogenesis (GO:0010927)	5.18272854
15	primary alcohol catabolic process (GO:0034310)	5.07751985
16	sperm capacitation (GO:0048240)	4.93434493
17	cell projection assembly (GO:0030031)	4.56956436
18	vitamin transmembrane transport (GO:0035461)	4.49530604
19	ethanol metabolic process (GO:0006067)	4.34062571
20	regulation of microtubule-based movement (GO:0060632)	4.29933472
21	centriole replication (GO:0007099)	4.23610038
22	determination of left/right symmetry (GO:0007368)	4.15029977
23	diterpenoid biosynthetic process (GO:0016102)	4.09833451
24	one-carbon compound transport (GO:0019755)	3.96474847
25	determination of bilateral symmetry (GO:0009855)	3.95750084
26	specification of symmetry (GO:0009799)	3.90569829
27	sperm motility (GO:0030317)	3.87961368
28	smoothened signaling pathway (GO:0007224)	3.85146852
29	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.81393458
30	lateral ventricle development (GO:0021670)	3.81099001
31	negative regulation of T cell differentiation in thymus (GO:0033085)	3.79500169
32	GTP biosynthetic process (GO:0006183)	3.79355733
33	lung epithelium development (GO:0060428)	3.71461359
34	tolerance induction (GO:0002507)	3.68058569
35	glomerular epithelial cell development (GO:0072310)	3.62206101
36	establishment of apical/basal cell polarity (GO:0035089)	3.43513321
37	glutathione derivative metabolic process (GO:1901685)	3.36252460
38	glutathione derivative biosynthetic process (GO:1901687)	3.36252460
39	ethanol oxidation (GO:0006069)	3.32550798
40	UTP biosynthetic process (GO:0006228)	3.26643548
41	microtubule depolymerization (GO:0007019)	3.22118464
42	response to xenobiotic stimulus (GO:0009410)	3.21341235
43	regulation of interleukin-5 production (GO:0032674)	3.20838392
44	cytoplasmic microtubule organization (GO:0031122)	3.16837510
45	negative regulation of B cell mediated immunity (GO:0002713)	3.12367429
46	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.12367429
47	establishment of monopolar cell polarity (GO:0061162)	3.07359602
48	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.07359602
49	retinoic acid metabolic process (GO:0042573)	3.05562510
50	nucleotide phosphorylation (GO:0046939)	3.01841950
51	establishment of tissue polarity (GO:0007164)	3.01550741
52	establishment of planar polarity (GO:0001736)	3.01550741
53	negative regulation of inclusion body assembly (GO:0090084)	3.00853643
54	axonemal dynein complex assembly (GO:0070286)	22.9159353
55	microtubule-based process (GO:0007017)	2.97704309
56	intra-S DNA damage checkpoint (GO:0031573)	2.95184048
57	retinal rod cell development (GO:0046548)	2.92479447
58	organelle assembly (GO:0070925)	2.90078634
59	UTP metabolic process (GO:0046051)	2.89115522
60	positive regulation of tolerance induction (GO:0002645)	2.88792473
61	negative regulation of humoral immune response (GO:0002921)	2.87902179
62	terpenoid biosynthetic process (GO:0016114)	2.86902170
63	regulation of autophagic vacuole assembly (GO:2000785)	2.81676350
64	nucleoside diphosphate metabolic process (GO:0009132)	2.81073339
65	retinol metabolic process (GO:0042572)	2.80075265
66	positive regulation of smoothened signaling pathway (GO:0045880)	2.79851136
67	ADP metabolic process (GO:0046031)	2.74147047
68	primary alcohol metabolic process (GO:0034308)	2.68174691
69	exogenous drug catabolic process (GO:0042738)	2.65963153
70	microtubule polymerization or depolymerization (GO:0031109)	2.65907300
71	regulation of podosome assembly (GO:0071801)	2.64789211
72	regulation of germinal center formation (GO:0002634)	2.64607132
73	nonmotile primary cilium assembly (GO:0035058)	2.63819724
74	lateral sprouting from an epithelium (GO:0060601)	2.61069392
75	regulation of vacuole organization (GO:0044088)	2.57814763
76	phenol-containing compound catabolic process (GO:0019336)	2.54775634
77	apical protein localization (GO:0045176)	2.53582653
78	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.53526459
79	regulation of interleukin-13 production (GO:0032656)	2.47842280
80	asymmetric protein localization (GO:0008105)	2.47348254
81	heart looping (GO:0001947)	2.45157039
82	hydrogen peroxide biosynthetic process (GO:0050665)	2.42748582
83	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.42413994
84	carnitine metabolic process (GO:0009437)	2.36862486
85	embryonic heart tube morphogenesis (GO:0003143)	2.36176265
86	aldehyde catabolic process (GO:0046185)	2.35941682
87	regulation of collateral sprouting (GO:0048670)	2.30903377
88	regulation of smoothened signaling pathway (GO:0008589)	2.29101276
89	CTP metabolic process (GO:0046036)	2.24811640
90	CTP biosynthetic process (GO:0006241)	2.24811640
91	photoreceptor cell maintenance (GO:0045494)	2.21497346
92	O-glycan processing (GO:0016266)	2.20542353
93	excretion (GO:0007588)	2.19953653
94	protein polyglutamylation (GO:0018095)	2.18320236
95	cilium movement (GO:0003341)	18.3430948
96	cilium or flagellum-dependent cell motility (GO:0001539)	17.8190811
97	epithelial cilium movement (GO:0003351)	17.1059466
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	15.6678071
99	motile cilium assembly (GO:0044458)	15.5393263
100	axoneme assembly (GO:0035082)	10.4135537

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.21023901
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.18208338
3	DROSHA_22980978_ChIP-Seq_HELA_Human	3.08481849
4	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.57074903
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.55258424
6	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.26141921
7	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.07666635
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.01548258
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.00684820
10	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.99155306
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.92412599
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.81708429
13	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.74071452
14	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73166995
15	AHR_22903824_ChIP-Seq_MCF-7_Human	1.73060183
16	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.72208161
17	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.60613222
18	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.59508735
19	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53933361
20	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.53104679
21	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.51822739
22	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.51248108
23	VDR_22108803_ChIP-Seq_LS180_Human	1.50842455
24	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.48318195
25	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.47223585
26	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.45964006
27	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.43007385
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40177259
29	* TP63_23658742_ChIP-Seq_EP156T_Human	1.38225629
30	TP53_18474530_ChIP-ChIP_U2OS_Human	1.38039354
31	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.37933907
32	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37865387
33	SMRT_27268052_Chip-Seq_Bcells_Human	1.37661391
34	* STAT1_20625510_ChIP-Seq_HELA_Human	1.35601753
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35418574
36	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35418574
37	FUS_26573619_Chip-Seq_HEK293_Human	1.34018641
38	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.33966202
39	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.32822000
40	SMC4_20622854_ChIP-Seq_HELA_Human	1.32784595
41	* PHF8_20622853_ChIP-Seq_HELA_Human	1.32220754
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31129661
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.28679081
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27041625
45	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26277369
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25855566
47	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.25250635
48	* ETV1_20927104_ChIP-Seq_GIST48_Human	1.24129374
49	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23061646
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.22598492
51	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.20545210
52	* STAT3_23295773_ChIP-Seq_U87_Human	1.20248920
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19347114
54	* PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.18466683
55	TP63_22573176_ChIP-Seq_HFKS_Human	1.18286892
56	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.18217184
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18171720
58	* TCF4_22108803_ChIP-Seq_LS180_Human	1.17943450
59	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.17460997
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.16155776
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13198409
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13198409
63	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.12618014
64	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.12316388
65	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.10135263
66	* TBL1_22424771_ChIP-Seq_293T_Human	1.10088699
67	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.07463917
68	P300_19829295_ChIP-Seq_ESCs_Human	1.06707536
69	KLF5_25053715_ChIP-Seq_YYC3_Human	1.05641614
70	CBP_21632823_ChIP-Seq_H3396_Human	1.05544142
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.04479596
72	* NFYA_21822215_ChIP-Seq_K562_Human	1.04323278
73	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.02994428
74	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02548986
75	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.01318643
76	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00879188
77	AR_20517297_ChIP-Seq_VCAP_Human	0.99945219
78	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99745527
79	* NFYB_21822215_ChIP-Seq_K562_Human	0.98856979
80	TCF4_23295773_ChIP-Seq_U87_Human	0.98695782
81	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98533189
82	GBX2_23144817_ChIP-Seq_PC3_Human	0.98496043
83	* RBPJ_21746931_ChIP-Seq_IB4_Human	0.98083643
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97623211
85	RXR_22108803_ChIP-Seq_LS180_Human	0.96781707
86	TP53_16413492_ChIP-PET_HCT116_Human	0.96731891
87	CEBPB_22108803_ChIP-Seq_LS180_Human	0.96504754
88	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.96393632
89	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.94971160
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.94701396
91	* CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.93439316
92	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92889263
93	* GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92656229
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92572847
95	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.92505624
96	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.92084257
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91824281
98	GATA4_25053715_ChIP-Seq_YYC3_Human	0.90752037
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.90430389
100	ER_23166858_ChIP-Seq_MCF-7_Human	0.89845386

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	8.00987207
2	MP0008875_abnormal_xenobiotic_pharmacok	4.40719333
3	MP0001984_abnormal_olfaction	4.21410114
4	MP0003136_yellow_coat_color	4.06923792
5	MP0000566_synostosis	3.92219914
6	MP0002132_abnormal_respiratory_system	3.87811220
7	MP0004133_heterotaxia	3.62650389
8	MP0005623_abnormal_meninges_morphology	3.49304814
9	MP0004043_abnormal_pH_regulation	2.91590050
10	MP0002277_abnormal_respiratory_mucosa	2.84558447
11	MP0002282_abnormal_trachea_morphology	2.84232412
12	MP0003878_abnormal_ear_physiology	2.77302302
13	MP0005377_hearing/vestibular/ear_phenot	2.77302302
14	MP0008789_abnormal_olfactory_epithelium	2.67644387
15	MP0003806_abnormal_nucleotide_metabolis	2.65520974
16	MP0010030_abnormal_orbit_morphology	2.44732480
17	MP0004019_abnormal_vitamin_homeostasis	2.36314954
18	MP0000383_abnormal_hair_follicle	1.99226800
19	MP0001485_abnormal_pinna_reflex	1.91676093
20	MP0005394_taste/olfaction_phenotype	1.90035108
21	MP0005499_abnormal_olfactory_system	1.90035108
22	MP0009780_abnormal_chondrocyte_physiolo	1.78610024
23	MP0002822_catalepsy	1.75277300
24	MP0002734_abnormal_mechanical_nocicepti	1.58604205
25	MP0002249_abnormal_larynx_morphology	1.56906887
26	MP0009379_abnormal_foot_pigmentation	1.56062394
27	MP0002928_abnormal_bile_duct	1.54060406
28	MP0002160_abnormal_reproductive_system	1.50737012
29	MP0010678_abnormal_skin_adnexa	1.45944851
30	MP0003879_abnormal_hair_cell	1.45290323
31	MP0000026_abnormal_inner_ear	1.38062190
32	MP0002233_abnormal_nose_morphology	1.24812665
33	MP0001293_anophthalmia	1.22034107
34	MP0002638_abnormal_pupillary_reflex	1.19655819
35	MP0003656_abnormal_erythrocyte_physiolo	1.19017260
36	MP0003283_abnormal_digestive_organ	1.16653048
37	MP0005408_hypopigmentation	1.15191622
38	MP0001765_abnormal_ion_homeostasis	1.13237956
39	MP0009046_muscle_twitch	1.12780816
40	MP0001346_abnormal_lacrimal_gland	1.12487867
41	MP0005171_absent_coat_pigmentation	1.00748769
42	MP0001324_abnormal_eye_pigmentation	1.00009302
43	MP0003937_abnormal_limbs/digits/tail_de	0.99878321
44	MP0005253_abnormal_eye_physiology	0.99093392
45	MP0003938_abnormal_ear_development	0.97232582
46	MP0005083_abnormal_biliary_tract	0.96740081
47	MP0002909_abnormal_adrenal_gland	0.93884172
48	MP0005503_abnormal_tendon_morphology	0.93305518
49	MP0005365_abnormal_bile_salt	0.92948008
50	MP0005551_abnormal_eye_electrophysiolog	0.88060760
51	MP0003698_abnormal_male_reproductive	0.85764346
52	MP0001963_abnormal_hearing_physiology	0.79051293
53	MP0000049_abnormal_middle_ear	0.78671263
54	MP0008995_early_reproductive_senescence	0.78063624
55	MP0005085_abnormal_gallbladder_physiolo	0.77695086
56	MP0001929_abnormal_gametogenesis	0.77226111
57	MP0002168_other_aberrant_phenotype	0.76007316
58	MP0004883_abnormal_blood_vessel	0.75412200
59	MP0005636_abnormal_mineral_homeostasis	0.75243583
60	MP0005391_vision/eye_phenotype	0.73235832
61	MP0002116_abnormal_craniofacial_bone	0.72390351
62	MP0005248_abnormal_Harderian_gland	0.72205562
63	MP0009765_abnormal_xenobiotic_induced	0.71700999
64	MP0003880_abnormal_central_pattern	0.71648296
65	MP0002098_abnormal_vibrissa_morphology	0.70933033
66	MP0001502_abnormal_circadian_rhythm	0.70742284
67	MP0002876_abnormal_thyroid_physiology	0.70356117
68	MP0003942_abnormal_urinary_system	0.67133308
69	MP0005195_abnormal_posterior_eye	0.66697163
70	MP0001529_abnormal_vocalization	0.66513780
71	MP0001486_abnormal_startle_reflex	0.65849824
72	MP0005389_reproductive_system_phenotype	0.65718733
73	MP0001970_abnormal_pain_threshold	0.65566259
74	MP0000955_abnormal_spinal_cord	0.64894939
75	MP0003861_abnormal_nervous_system	0.64470917
76	MP0000631_abnormal_neuroendocrine_gland	0.64411173
77	MP0002938_white_spotting	0.63391137
78	MP0002896_abnormal_bone_mineralization	0.59012606
79	MP0000467_abnormal_esophagus_morphology	0.57774266
80	MP0009745_abnormal_behavioral_response	0.57706465
81	MP0002735_abnormal_chemical_nociception	0.57691579
82	MP0009703_decreased_birth_body	0.57114133
83	MP0003890_abnormal_embryonic-extraembry	0.56618208
84	MP0005508_abnormal_skeleton_morphology	0.56454102
85	MP0005164_abnormal_response_to	0.56107400
86	MP0002272_abnormal_nervous_system	0.55393998
87	MP0004742_abnormal_vestibular_system	0.52778556
88	MP0004885_abnormal_endolymph	0.52577263
89	MP0005388_respiratory_system_phenotype	0.51618063
90	MP0002133_abnormal_respiratory_system	0.51618063
91	MP0006072_abnormal_retinal_apoptosis	0.49821860
92	MP0002084_abnormal_developmental_patter	0.49813624
93	MP0002092_abnormal_eye_morphology	0.48415214
94	MP0006036_abnormal_mitochondrial_physio	0.47382756
95	MP0001663_abnormal_digestive_system	0.46904556
96	MP0005165_increased_susceptibility_to	0.46323677
97	MP0000343_altered_response_to	0.46200762
98	MP0005395_other_phenotype	0.46175217
99	MP0001286_abnormal_eye_development	0.46129897
100	MP0002572_abnormal_emotion/affect_behav	0.45094906

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rhinitis (HP:0012384)	9.82913172
2	Chronic bronchitis (HP:0004469)	7.48632181
3	Bronchiectasis (HP:0002110)	7.05591428
4	Nasal polyposis (HP:0100582)	6.75295273
5	Abnormality of the nasal mucosa (HP:0000433)	5.59190592
6	Occipital encephalocele (HP:0002085)	4.41197407
7	True hermaphroditism (HP:0010459)	4.26162472
8	Chronic sinusitis (HP:0011109)	4.21350481
9	Recurrent sinusitis (HP:0011108)	4.19552938
10	Pancreatic fibrosis (HP:0100732)	4.11013273
11	Bronchitis (HP:0012387)	4.06847193
12	Infertility (HP:0000789)	3.91627482
13	Abnormality of midbrain morphology (HP:0002418)	3.62852327
14	Molar tooth sign on MRI (HP:0002419)	3.62852327
15	Recurrent otitis media (HP:0000403)	3.62509470
16	Nephronophthisis (HP:0000090)	3.57915205
17	Pancreatic cysts (HP:0001737)	3.45536211
18	Cystic liver disease (HP:0006706)	3.38040109
19	Chronic hepatic failure (HP:0100626)	3.34065642
20	Male infertility (HP:0003251)	2.78568972
21	Chronic otitis media (HP:0000389)	2.78331526
22	Postaxial foot polydactyly (HP:0001830)	2.68728262
23	Abnormality of the renal medulla (HP:0100957)	2.68187126
24	Atelectasis (HP:0100750)	2.66764936
25	Medial flaring of the eyebrow (HP:0010747)	2.65217808
26	Tubular atrophy (HP:0000092)	2.61855523
27	Tubulointerstitial nephritis (HP:0001970)	2.55211923
28	Congenital hepatic fibrosis (HP:0002612)	2.49357095
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.47540971
30	Anencephaly (HP:0002323)	2.37293065
31	Male pseudohermaphroditism (HP:0000037)	2.22325482
32	Congenital primary aphakia (HP:0007707)	2.21580151
33	Gait imbalance (HP:0002141)	2.19495016
34	Sclerocornea (HP:0000647)	2.18619833
35	Furrowed tongue (HP:0000221)	2.10552852
36	Hyperactive renin-angiotensin system (HP:0000841)	2.06407102
37	Oculomotor apraxia (HP:0000657)	2.04177830
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.5206344
39	Abnormal respiratory motile cilium physiology (HP:0012261)	11.2679056
40	Abnormal ciliary motility (HP:0012262)	11.1551218
41	Abnormal respiratory epithelium morphology (HP:0012253)	10.6182688
42	Abnormal respiratory motile cilium morphology (HP:0005938)	10.6182688
43	Absent/shortened dynein arms (HP:0200106)	10.3484422
44	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.3484422
45	Nephrogenic diabetes insipidus (HP:0009806)	1.91686323
46	Postaxial hand polydactyly (HP:0001162)	1.90212677
47	Short nail (HP:0001799)	1.87891411
48	Bell-shaped thorax (HP:0001591)	1.82084421
49	Tubulointerstitial abnormality (HP:0001969)	1.79391666
50	Polydipsia (HP:0001959)	1.77033655
51	Abnormal drinking behavior (HP:0030082)	1.77033655
52	Recurrent bronchitis (HP:0002837)	1.71870013
53	Preaxial hand polydactyly (HP:0001177)	1.71445261
54	Abnormality of dentin (HP:0010299)	1.69243263
55	Poor coordination (HP:0002370)	1.67200058
56	Stage 5 chronic kidney disease (HP:0003774)	1.63119601
57	Vaginal atresia (HP:0000148)	1.61695293
58	Genital tract atresia (HP:0001827)	1.60258987
59	Nephropathy (HP:0000112)	1.58658326
60	Abnormality of the dental root (HP:0006486)	1.53694517
61	Taurodontia (HP:0000679)	1.53694517
62	Abnormality of permanent molar morphology (HP:0011071)	1.53694517
63	Bile duct proliferation (HP:0001408)	1.47827880
64	Abnormal biliary tract physiology (HP:0012439)	1.47827880
65	Asplenia (HP:0001746)	1.47327695
66	Tubulointerstitial fibrosis (HP:0005576)	1.44915517
67	Supernumerary spleens (HP:0009799)	1.44564785
68	Abnormality of the renal cortex (HP:0011035)	1.42753890
69	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.42639086
70	Decreased circulating renin level (HP:0003351)	1.42335162
71	Median cleft lip (HP:0000161)	1.42300148
72	Abnormality of molar morphology (HP:0011070)	1.41917926
73	Abnormality of molar (HP:0011077)	1.41917926
74	Absent frontal sinuses (HP:0002688)	1.39767631
75	Abnormality of the dental pulp (HP:0006479)	1.35715588
76	Narrow forehead (HP:0000341)	1.30067226
77	Broad distal phalanx of finger (HP:0009836)	1.29006071
78	Abdominal situs inversus (HP:0003363)	1.27875311
79	Abnormality of abdominal situs (HP:0011620)	1.27875311
80	Bifid scrotum (HP:0000048)	1.20093585
81	Prominent nasal bridge (HP:0000426)	1.17703091
82	Renal salt wasting (HP:0000127)	1.16937746
83	Aganglionic megacolon (HP:0002251)	1.16173222
84	Polyuria (HP:0000103)	1.10314578
85	Optic nerve coloboma (HP:0000588)	1.09833403
86	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.09444263
87	Retinitis pigmentosa (HP:0000510)	1.07402876
88	Highly arched eyebrow (HP:0002553)	1.06621989
89	Nonprogressive disorder (HP:0003680)	1.05374371
90	Aplasia/Hypoplasia of the lens (HP:0008063)	1.05065858
91	Multicystic kidney dysplasia (HP:0000003)	1.01812889
92	Short thorax (HP:0010306)	1.01096788
93	Hyperkalemia (HP:0002153)	0.98203926
94	Abnormality of renal excretion (HP:0011036)	0.98056965
95	Anophthalmia (HP:0000528)	0.97322375
96	Abnormality of renin-angiotensin system (HP:0000847)	0.96997000
97	Hyperaldosteronism (HP:0000859)	0.96242829
98	Holoprosencephaly (HP:0001360)	0.95961836
99	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	0.93972653
100	Intellectual disability, moderate (HP:0002342)	0.92967350

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	3.81674377
2	MST4	3.69680718
3	PTK2B	3.08294736
4	EPHA2	3.06185689
5	MAPKAPK3	2.50868286
6	CCNB1	2.17877081
7	MAPK15	12.5694614
8	STK16	1.84430217
9	MAP3K2	1.83253064
10	STK24	1.51182639
11	MUSK	1.49731395
12	TSSK6	1.48783376
13	NME1	1.42518109
14	WEE1	1.28225623
15	TLK1	1.27662783
16	INSRR	1.17160793
17	MAP3K4	1.11226837
18	WNK4	1.09493024
19	TTK	1.07144896
20	TRPM7	1.02323485
21	CSK	0.91894952
22	LRRK2	0.85667759
23	ERBB3	0.84731553
24	BRSK2	0.84418426
25	PASK	0.82467212
26	NEK9	0.81966801
27	EEF2K	0.81372606
28	NEK6	0.81325049
29	MAP3K3	0.81246175
30	STK38L	0.79264607
31	DYRK3	0.78191780
32	BCR	0.77232508
33	STK39	0.76492238
34	MAP2K7	0.73915405
35	PINK1	0.73555060
36	WNK3	0.73267799
37	LATS1	0.69023665
38	MAP3K7	0.68992498
39	CAMKK1	0.67243477
40	SMG1	0.67023965
41	MAP3K12	0.66522893
42	EPHA3	0.65691521
43	BMPR1B	0.64039478
44	AURKA	0.63032412
45	MAP2K4	0.62374010
46	IRAK1	0.62305093
47	EPHB1	0.57180324
48	CAMKK2	0.55041190
49	PRKCI	0.53628077
50	ERBB2	0.52168470
51	CDK8	0.50732499
52	GRK1	0.50470068
53	STK38	0.47749123
54	STK10	0.47244716
55	MST1R	0.45128270
56	MET	0.43627118
57	RPS6KB2	0.42568272
58	MARK2	0.42292507
59	VRK1	0.39200515
60	CDK3	0.38772887
61	NTRK2	0.37252276
62	DYRK1B	0.36202774
63	NTRK3	0.35567929
64	PRKCQ	0.34692715
65	TNIK	0.34621605
66	CAMK2G	0.32618720
67	TAOK1	0.31769443
68	AKT2	0.31183824
69	GRK6	0.28876821
70	MAPKAPK5	0.28607941
71	PRKACA	0.28076647
72	RET	0.27592343
73	PTK6	0.25712309
74	SGK1	0.25617995
75	PRKCD	0.25531072
76	BMX	0.25059767
77	MAPK13	0.23841446
78	ADRBK1	0.22540045
79	MAP4K2	0.20242557
80	PRKCG	0.19601394
81	EPHA4	0.19472636
82	DYRK1A	0.18420605
83	CAMK2A	0.17083168
84	PRKCA	0.16542656
85	PRKCZ	0.16460167
86	SGK494	0.14610765
87	SGK223	0.14610765
88	ROCK1	0.14605984
89	PRKAA2	0.14233073
90	RPS6KA5	0.13458906
91	FGFR2	0.13173072
92	ROCK2	0.12660560
93	CSNK1G2	0.12396819
94	GSK3A	0.12090146
95	TBK1	0.11655140
96	RIPK4	0.10799560
97	MAP3K6	0.10297432
98	RPS6KA2	0.09849517
99	SRC	0.09190450
100	ABL1	0.09120202

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.36745179
2	Chemical carcinogenesis_Homo sapiens_hsa05204	4.44625557
3	Huntingtons disease_Homo sapiens_hsa05016	4.29823543
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.23681249
5	Phenylalanine metabolism_Homo sapiens_hsa00360	4.01976578
6	Histidine metabolism_Homo sapiens_hsa00340	3.81529724
7	Tyrosine metabolism_Homo sapiens_hsa00350	3.20852724
8	Glutathione metabolism_Homo sapiens_hsa00480	2.95156776
9	beta-Alanine metabolism_Homo sapiens_hsa00410	2.51076524
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10362614
11	Retinol metabolism_Homo sapiens_hsa00830	2.06776244
12	Caffeine metabolism_Homo sapiens_hsa00232	1.66951975
13	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.58278646
14	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.54159381
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53772576
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.52915268
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.51974685
18	Parkinsons disease_Homo sapiens_hsa05012	1.51757390
19	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.38910118
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.38088165
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.36948542
22	Peroxisome_Homo sapiens_hsa04146	1.35334423
23	Alzheimers disease_Homo sapiens_hsa05010	1.34612399
24	Basal cell carcinoma_Homo sapiens_hsa05217	1.30615832
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25467563
26	Nicotine addiction_Homo sapiens_hsa05033	1.24153056
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22250896
28	Tight junction_Homo sapiens_hsa04530	1.11330625
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.09388705
30	ABC transporters_Homo sapiens_hsa02010	1.08034384
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06789499
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06601077
33	Notch signaling pathway_Homo sapiens_hsa04330	1.05460337
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04757527
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04479700
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04406572
37	Fatty acid degradation_Homo sapiens_hsa00071	1.01603052
38	Salivary secretion_Homo sapiens_hsa04970	1.00112656
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.91849709
40	Sphingolipid metabolism_Homo sapiens_hsa00600	0.88854910
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83999023
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81840749
43	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.72503274
44	Ribosome_Homo sapiens_hsa03010	0.69296471
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69052511
46	Taste transduction_Homo sapiens_hsa04742	0.65957980
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64944191
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.64912170
49	Cocaine addiction_Homo sapiens_hsa05030	0.64838826
50	Metabolic pathways_Homo sapiens_hsa01100	0.61125839
51	Olfactory transduction_Homo sapiens_hsa04740	0.60191294
52	Hippo signaling pathway_Homo sapiens_hsa04390	0.57893945
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57164755
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.54832044
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.54332622
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54207593
57	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.54080168
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.53286733
59	Butanoate metabolism_Homo sapiens_hsa00650	0.50669042
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49550498
61	Purine metabolism_Homo sapiens_hsa00230	0.49459611
62	Phototransduction_Homo sapiens_hsa04744	0.48323757
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47520842
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46675892
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45165614
66	RNA polymerase_Homo sapiens_hsa03020	0.44544755
67	Alcoholism_Homo sapiens_hsa05034	0.44499945
68	Circadian rhythm_Homo sapiens_hsa04710	0.44049752
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42180780
70	Complement and coagulation cascades_Homo sapiens_hsa04610	0.40828671
71	Arginine biosynthesis_Homo sapiens_hsa00220	0.39327074
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.38469186
73	Amphetamine addiction_Homo sapiens_hsa05031	0.36825826
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36385045
75	PPAR signaling pathway_Homo sapiens_hsa03320	0.36184445
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.35267263
77	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.34831543
78	Axon guidance_Homo sapiens_hsa04360	0.33128310
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32710301
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.29512440
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.28657639
82	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.28282904
83	Pancreatic secretion_Homo sapiens_hsa04972	0.28076917
84	Serotonergic synapse_Homo sapiens_hsa04726	0.27457187
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27293110
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26596088
87	Bile secretion_Homo sapiens_hsa04976	0.26268287
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.26125900
89	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.25272370
90	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.25131246
91	Choline metabolism in cancer_Homo sapiens_hsa05231	0.23015935
92	Melanogenesis_Homo sapiens_hsa04916	0.22386267
93	Mineral absorption_Homo sapiens_hsa04978	0.22320872
94	Propanoate metabolism_Homo sapiens_hsa00640	0.18375542
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.17678501
96	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.16648778
97	Hepatitis C_Homo sapiens_hsa05160	0.15907417
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.15601998
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.14868089
100	Protein export_Homo sapiens_hsa03060	0.14660955

FAM183A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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