ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA packaging (GO:0006323)	9.79270154
2	sperm capacitation (GO:0048240)	9.48664383
3	single strand break repair (GO:0000012)	9.13166767
4	spermatid nucleus differentiation (GO:0007289)	9.12752931
5	plasma membrane fusion (GO:0045026)	8.45295227
6	microtubule depolymerization (GO:0007019)	8.16055301
7	spermatid development (GO:0007286)	8.11134714
8	sexual reproduction (GO:0019953)	7.88367956
9	sperm-egg recognition (GO:0035036)	7.66027115
10	binding of sperm to zona pellucida (GO:0007339)	7.31114397
11	negative regulation of inclusion body assembly (GO:0090084)	7.02922275
12	rRNA methylation (GO:0031167)	6.96113128
13	reproduction (GO:0000003)	6.96089634
14	multicellular organism reproduction (GO:0032504)	6.95677992
15	calcium ion-dependent exocytosis (GO:0017156)	6.69369395
16	microtubule polymerization or depolymerization (GO:0031109)	6.55852054
17	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	6.55790869
18	protein polyglutamylation (GO:0018095)	6.43535385
19	cell-cell recognition (GO:0009988)	6.30037335
20	axonemal dynein complex assembly (GO:0070286)	6.19631841
21	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.17875107
22	protein targeting to Golgi (GO:0000042)	6.10514840
23	cellular ketone body metabolic process (GO:0046950)	6.07935114
24	spermatogenesis (GO:0007283)	6.05284329
25	male gamete generation (GO:0048232)	6.03186479
26	establishment of protein localization to Golgi (GO:0072600)	5.85472507
27	rRNA modification (GO:0000154)	5.85294555
28	phosphatidylethanolamine metabolic process (GO:0046337)	5.71950528
29	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.67339609
30	microtubule severing (GO:0051013)	5.61193972
31	gamete generation (GO:0007276)	5.50826135
32	chromatin silencing (GO:0006342)	5.43767316
33	ketone body metabolic process (GO:1902224)	5.36472846
34	positive regulation of Rab GTPase activity (GO:0032851)	5.22045903
35	regulation of Rab GTPase activity (GO:0032313)	5.22045903
36	regulation of inclusion body assembly (GO:0090083)	4.99435293
37	motile cilium assembly (GO:0044458)	4.97885413
38	regulation of cilium movement (GO:0003352)	4.93996517
39	centriole replication (GO:0007099)	4.92942863
40	single fertilization (GO:0007338)	4.81381690
41	germ cell development (GO:0007281)	4.61252307
42	RNA destabilization (GO:0050779)	4.51247447
43	cell wall macromolecule catabolic process (GO:0016998)	4.47728692
44	multicellular organismal reproductive process (GO:0048609)	4.41904594
45	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.40444200
46	cilium or flagellum-dependent cell motility (GO:0001539)	4.37824581
47	protein localization to Golgi apparatus (GO:0034067)	4.35987186
48	regulation of transcription involved in cell fate commitment (GO:0060850)	4.35325815
49	centriole assembly (GO:0098534)	4.35184387
50	nucleus organization (GO:0006997)	4.32606490
51	coenzyme catabolic process (GO:0009109)	4.28893828
52	cell wall macromolecule metabolic process (GO:0044036)	4.22548041
53	negative regulation of Rho protein signal transduction (GO:0035024)	4.05472682
54	glycerol ether metabolic process (GO:0006662)	4.04640031
55	regulation of centriole replication (GO:0046599)	3.95959470
56	fertilization (GO:0009566)	3.91663118
57	negative regulation of gene expression, epigenetic (GO:0045814)	3.78174501
58	ether metabolic process (GO:0018904)	3.73142545
59	epithelial cilium movement (GO:0003351)	3.69414010
60	nucleosome disassembly (GO:0006337)	3.66554993
61	protein-DNA complex disassembly (GO:0032986)	3.66554993
62	seminiferous tubule development (GO:0072520)	3.62005819
63	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.53344546
64	histone H3-K9 demethylation (GO:0033169)	3.43690240
65	regulation of interleukin-13 production (GO:0032656)	3.38719598
66	regulation of T-helper 2 cell differentiation (GO:0045628)	3.37898216
67	peptidyl-threonine dephosphorylation (GO:0035970)	3.37894744
68	response to acidic pH (GO:0010447)	3.35204005
69	musculoskeletal movement (GO:0050881)	3.35081212
70	multicellular organismal movement (GO:0050879)	3.35081212
71	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.34221546
72	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.34221546
73	polyamine biosynthetic process (GO:0006596)	3.33336484
74	organic cation transport (GO:0015695)	3.31835444
75	cerebral cortex neuron differentiation (GO:0021895)	3.30138768
76	regulation of microtubule-based movement (GO:0060632)	3.26186380
77	cilium movement (GO:0003341)	3.25380333
78	cell differentiation involved in metanephros development (GO:0072202)	3.22063164
79	glomerular visceral epithelial cell development (GO:0072015)	3.21163739
80	cranial nerve morphogenesis (GO:0021602)	3.18685860
81	DNA conformation change (GO:0071103)	3.16338881
82	glomerular epithelial cell development (GO:0072310)	3.13183408
83	cellular response to pH (GO:0071467)	3.13182010
84	homeostasis of number of cells within a tissue (GO:0048873)	3.13068997
85	protein depolymerization (GO:0051261)	3.06106709
86	peptidyl-proline hydroxylation (GO:0019511)	3.05748919
87	NAD biosynthetic process (GO:0009435)	3.05184705
88	cell recognition (GO:0008037)	3.02042560
89	multicellular organismal development (GO:0007275)	2.97642956
90	negative regulation of histone methylation (GO:0031061)	2.95266520
91	membrane protein intracellular domain proteolysis (GO:0031293)	2.92233052
92	regulation of somitogenesis (GO:0014807)	2.85330256
93	positive regulation of skeletal muscle tissue development (GO:0048643)	2.81246010
94	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.77505895
95	regulation of ARF GTPase activity (GO:0032312)	2.74869723
96	acrosome reaction (GO:0007340)	12.6510922
97	sperm motility (GO:0030317)	11.6378865
98	fusion of sperm to egg plasma membrane (GO:0007342)	11.1327351
99	response to pheromone (GO:0019236)	10.3154799
100	chromosome condensation (GO:0030261)	10.2433496

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.85286806
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.93882692
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.80298142
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38331147
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.38331147
6	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.27537397
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.17423982
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.12086655
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.12086655
10	ERA_21632823_ChIP-Seq_H3396_Human	2.10276384
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09116364
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.08567067
13	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.94743786
14	RAC3_21632823_ChIP-Seq_H3396_Human	1.93303229
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90474751
16	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.89955452
17	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.87652100
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.86242029
19	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.82669050
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.82080345
21	CTCF_27219007_Chip-Seq_Bcells_Human	1.81420988
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.78301473
23	E2F1_20622854_ChIP-Seq_HELA_Human	1.72884578
24	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.68851715
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68639522
26	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.67688592
27	FUS_26573619_Chip-Seq_HEK293_Human	1.67314449
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66897562
29	BCOR_27268052_Chip-Seq_Bcells_Human	1.66675599
30	SMC4_20622854_ChIP-Seq_HELA_Human	1.66174205
31	P68_20966046_ChIP-Seq_HELA_Human	1.63533417
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.62457440
33	PHF8_20622854_ChIP-Seq_HELA_Human	1.60903206
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.56762500
35	CTCF_20526341_ChIP-Seq_ESCs_Human	1.56664581
36	MYC_19829295_ChIP-Seq_ESCs_Human	1.56411092
37	TP63_22573176_ChIP-Seq_HFKS_Human	1.56004790
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.55954874
39	LXR_22292898_ChIP-Seq_THP-1_Human	1.53118462
40	EZH2_22144423_ChIP-Seq_EOC_Human	1.48390026
41	OCT4_20526341_ChIP-Seq_ESCs_Human	1.47099258
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46485251
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.46173844
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.44933251
45	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.43319776
46	P300_27268052_Chip-Seq_Bcells_Human	1.42772239
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.41450072
48	RUNX_20019798_ChIP-Seq_JUKART_Human	1.40637343
49	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.39673424
50	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.37860963
51	AR_25329375_ChIP-Seq_VCAP_Human	1.36428300
52	TP53_18474530_ChIP-ChIP_U2OS_Human	1.35215951
53	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.34400005
54	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.32650574
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32344429
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31992038
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.31363743
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.29377820
59	RBPJ_21746931_ChIP-Seq_IB4_Human	1.29153075
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27900327
61	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.27727471
62	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.26918236
63	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.26656693
64	CEBPB_22108803_ChIP-Seq_LS180_Human	1.24909489
65	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.24469747
66	ERG_20517297_ChIP-Seq_VCAP_Human	1.22991241
67	ETV1_20927104_ChIP-Seq_GIST48_Human	1.22937365
68	SA1_27219007_Chip-Seq_Bcells_Human	1.20830986
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18727689
70	P53_21459846_ChIP-Seq_SAOS-2_Human	1.18635255
71	SMRT_27268052_Chip-Seq_Bcells_Human	1.17457246
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16805211
73	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.16601648
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15076985
75	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.14354826
76	TAF15_26573619_Chip-Seq_HEK293_Human	1.13775486
77	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.13089115
78	NFYB_21822215_ChIP-Seq_K562_Human	1.12581619
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12493092
80	P300_19829295_ChIP-Seq_ESCs_Human	1.12388892
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.10920058
82	TBL1_22424771_ChIP-Seq_293T_Human	1.09889700
83	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.09494696
84	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08297969
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06806463
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06744524
87	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.06142714
88	PHF8_20622853_ChIP-Seq_HELA_Human	1.05083822
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04916185
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02958170
91	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.02004366
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99592214
93	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.99004328
94	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98147290
95	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.97639554
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96966016
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96966016
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.96598133
99	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.96258446
100	OCT4_19829295_ChIP-Seq_ESCs_Human	0.95481143

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.77817216
2	MP0003878_abnormal_ear_physiology	4.77817216
3	MP0005670_abnormal_white_adipose	4.55816509
4	MP0003698_abnormal_male_reproductive	4.48830103
5	MP0001348_abnormal_lacrimal_gland	4.13239534
6	MP0001929_abnormal_gametogenesis	3.84597448
7	MP0000678_abnormal_parathyroid_gland	2.86915645
8	MP0003011_delayed_dark_adaptation	2.56169609
9	MP0002161_abnormal_fertility/fecundity	2.49983997
10	MP0002132_abnormal_respiratory_system	2.30480763
11	MP0003718_maternal_effect	2.10808020
12	MP0005379_endocrine/exocrine_gland_phen	2.00550460
13	MP0005410_abnormal_fertilization	12.7626883
14	MP0003646_muscle_fatigue	1.91589897
15	MP0002249_abnormal_larynx_morphology	1.79498658
16	MP0002234_abnormal_pharynx_morphology	1.70474700
17	MP0005423_abnormal_somatic_nervous	1.69081853
18	MP0004510_myositis	1.67134147
19	MP0002210_abnormal_sex_determination	1.58393621
20	MP0009053_abnormal_anal_canal	1.58299974
21	MP0002282_abnormal_trachea_morphology	1.53523431
22	MP0001486_abnormal_startle_reflex	1.37275827
23	MP0002138_abnormal_hepatobiliary_system	1.35356497
24	MP0005310_abnormal_salivary_gland	1.33900450
25	MP0001145_abnormal_male_reproductive	1.32420434
26	MP0001485_abnormal_pinna_reflex	1.25466603
27	MP0000653_abnormal_sex_gland	1.24382354
28	MP0005248_abnormal_Harderian_gland	1.23526701
29	MP0002735_abnormal_chemical_nociception	1.23171665
30	MP0004742_abnormal_vestibular_system	1.21590867
31	MP0000534_abnormal_ureter_morphology	1.20361340
32	MP0002127_abnormal_cardiovascular_syste	1.19568087
33	MP0001765_abnormal_ion_homeostasis	1.17879307
34	MP0001968_abnormal_touch/_nociception	1.13858071
35	MP0004859_abnormal_synaptic_plasticity	1.05789560
36	MP0000681_abnormal_thyroid_gland	0.99588320
37	MP0001963_abnormal_hearing_physiology	0.99374850
38	MP0005395_other_phenotype	0.97060333
39	MP0002822_catalepsy	0.95024172
40	MP0000026_abnormal_inner_ear	0.90881961
41	MP0003879_abnormal_hair_cell	0.90027452
42	MP0000049_abnormal_middle_ear	0.82311197
43	MP0002229_neurodegeneration	0.81786471
44	MP0001879_abnormal_lymphatic_vessel	0.80506586
45	MP0005666_abnormal_adipose_tissue	0.80321237
46	MP0005367_renal/urinary_system_phenotyp	0.79934856
47	MP0000516_abnormal_urinary_system	0.79934856
48	MP0008877_abnormal_DNA_methylation	0.76685978
49	MP0009115_abnormal_fat_cell	0.76217458
50	MP0002733_abnormal_thermal_nociception	0.76090562
51	MP0000955_abnormal_spinal_cord	0.74644475
52	MP0005451_abnormal_body_composition	0.74620496
53	MP0004085_abnormal_heartbeat	0.70052407
54	MP0008569_lethality_at_weaning	0.69580088
55	MP0005375_adipose_tissue_phenotype	0.69131486
56	MP0002067_abnormal_sensory_capabilities	0.65130780
57	MP0005083_abnormal_biliary_tract	0.65007193
58	MP0005636_abnormal_mineral_homeostasis	0.62514493
59	MP0005551_abnormal_eye_electrophysiolog	0.61829809
60	MP0002557_abnormal_social/conspecific_i	0.59481895
61	MP0004484_altered_response_of	0.57573542
62	MP0005535_abnormal_body_temperature	0.54314254
63	MP0005167_abnormal_blood-brain_barrier	0.53848178
64	MP0008961_abnormal_basal_metabolism	0.53186644
65	MP0001666_abnormal_nutrient_absorption	0.53083842
66	MP0000003_abnormal_adipose_tissue	0.52372776
67	MP0005253_abnormal_eye_physiology	0.51299873
68	MP0004233_abnormal_muscle_weight	0.50052912
69	MP0001970_abnormal_pain_threshold	0.48570018
70	MP0008995_early_reproductive_senescence	0.48381075
71	MP0005623_abnormal_meninges_morphology	0.48319078
72	MP0003119_abnormal_digestive_system	0.48228181
73	MP0002572_abnormal_emotion/affect_behav	0.47563719
74	MP0006292_abnormal_olfactory_placode	0.46679300
75	MP0000249_abnormal_blood_vessel	0.46441808
76	MP0001905_abnormal_dopamine_level	0.45255767
77	MP0001501_abnormal_sleep_pattern	0.43747395
78	MP0003077_abnormal_cell_cycle	0.43238954
79	MP0003880_abnormal_central_pattern	0.41439967
80	MP0002254_reproductive_system_inflammat	0.40639426
81	MP0003137_abnormal_impulse_conducting	0.40626254
82	MP0002653_abnormal_ependyma_morphology	0.40570858
83	MP0000470_abnormal_stomach_morphology	0.40551463
84	MP0003172_abnormal_lysosome_physiology	0.40522092
85	MP0004036_abnormal_muscle_relaxation	0.39832937
86	MP0000613_abnormal_salivary_gland	0.39462168
87	MP0003699_abnormal_female_reproductive	0.39050692
88	MP0009745_abnormal_behavioral_response	0.38348533
89	MP0005084_abnormal_gallbladder_morpholo	0.37794070
90	MP0003091_abnormal_cell_migration	0.37185300
91	MP0002928_abnormal_bile_duct	0.36839700
92	MP0002272_abnormal_nervous_system	0.36680267
93	MP0000467_abnormal_esophagus_morphology	0.36373593
94	MP0009697_abnormal_copulation	0.36257697
95	MP0002734_abnormal_mechanical_nocicepti	0.36229940
96	MP0003936_abnormal_reproductive_system	0.34315512
97	MP0001440_abnormal_grooming_behavior	0.34239561
98	MP0005408_hypopigmentation	0.31558528
99	MP0009764_decreased_sensitivity_to	0.30749460
100	MP0005166_decreased_susceptibility_to	0.29955245

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.00249203
2	Absent/shortened dynein arms (HP:0200106)	6.17034739
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.17034739
4	Attenuation of retinal blood vessels (HP:0007843)	5.38913639
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.35554027
6	Asymmetric septal hypertrophy (HP:0001670)	5.29583377
7	Abnormal ciliary motility (HP:0012262)	4.73308011
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.58156281
9	Resting tremor (HP:0002322)	4.55863950
10	Abnormal respiratory epithelium morphology (HP:0012253)	4.48196811
11	Abnormal respiratory motile cilium morphology (HP:0005938)	4.48196811
12	Abnormal rod and cone electroretinograms (HP:0008323)	4.44746885
13	Nasal polyposis (HP:0100582)	4.41417548
14	Bell-shaped thorax (HP:0001591)	4.37708963
15	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.33135606
16	Infertility (HP:0000789)	4.22714750
17	Tubulointerstitial nephritis (HP:0001970)	4.19866618
18	Hyperkalemia (HP:0002153)	4.16620370
19	Hypoplastic ischia (HP:0003175)	4.15330880
20	Potter facies (HP:0002009)	4.08381092
21	Facial shape deformation (HP:0011334)	4.08381092
22	Male infertility (HP:0003251)	4.00966326
23	Abnormality of macular pigmentation (HP:0008002)	3.92958890
24	Azoospermia (HP:0000027)	3.83903453
25	Enlarged epiphyses (HP:0010580)	3.81538743
26	Chronic hepatic failure (HP:0100626)	3.76798371
27	Abnormal spermatogenesis (HP:0008669)	3.67284661
28	Abnormality of the ischium (HP:0003174)	3.66878144
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.63061743
30	Abnormality of the nasal mucosa (HP:0000433)	3.60048862
31	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.52329274
32	Unilateral renal agenesis (HP:0000122)	3.44382408
33	Cone-rod dystrophy (HP:0000548)	3.40144002
34	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.36418278
35	Impulsivity (HP:0100710)	3.15038556
36	Congenital malformation of the right heart (HP:0011723)	3.09132359
37	Double outlet right ventricle (HP:0001719)	3.09132359
38	Hypoplasia of the thymus (HP:0000778)	2.99655369
39	Abnormality of the aortic arch (HP:0012303)	2.94589890
40	Postural instability (HP:0002172)	2.85169361
41	Abnormal urine output (HP:0012590)	2.79254109
42	Renal dysplasia (HP:0000110)	2.78278745
43	Progressive sensorineural hearing impairment (HP:0000408)	2.75070604
44	Rhinitis (HP:0012384)	2.61668410
45	Generalized aminoaciduria (HP:0002909)	2.61417715
46	Stage 5 chronic kidney disease (HP:0003774)	2.56049707
47	Abnormality of potassium homeostasis (HP:0011042)	2.48495387
48	Hypoalphalipoproteinemia (HP:0003233)	2.42703382
49	Abnormality of the parathyroid morphology (HP:0011766)	2.42188025
50	Progressive cerebellar ataxia (HP:0002073)	2.40532403
51	Nephronophthisis (HP:0000090)	2.39354490
52	Abnormality of renal excretion (HP:0011036)	2.39220396
53	Truncal obesity (HP:0001956)	2.38191613
54	Abnormality of the costochondral junction (HP:0000919)	2.38055306
55	Flattened epiphyses (HP:0003071)	2.35861076
56	Epiphyseal dysplasia (HP:0002656)	2.31658490
57	Amelogenesis imperfecta (HP:0000705)	2.30562899
58	Abnormality of dental color (HP:0011073)	2.27392388
59	Ventricular tachycardia (HP:0004756)	2.25929627
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.24148515
61	Abnormal drinking behavior (HP:0030082)	2.19226525
62	Polydipsia (HP:0001959)	2.19226525
63	Polyuria (HP:0000103)	2.17498216
64	Tetany (HP:0001281)	2.15743110
65	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.13270024
66	Absent epiphyses (HP:0010577)	2.13270024
67	Abnormality of the pubic bones (HP:0003172)	2.12595951
68	Sensory axonal neuropathy (HP:0003390)	2.11474855
69	Portal hypertension (HP:0001409)	2.11428285
70	Hyponatremia (HP:0002902)	2.10648383
71	Bronchiectasis (HP:0002110)	2.09495559
72	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.09104780
73	Insulin-resistant diabetes mellitus (HP:0000831)	2.07421182
74	Osteomalacia (HP:0002749)	2.05958778
75	Hyperthyroidism (HP:0000836)	2.05869692
76	Abnormality of the renal medulla (HP:0100957)	2.01848586
77	Spastic paraparesis (HP:0002313)	2.01554347
78	Widely patent fontanelles and sutures (HP:0004492)	2.01313578
79	Tubulointerstitial abnormality (HP:0001969)	1.97136590
80	Decreased central vision (HP:0007663)	1.96416850
81	Hypoparathyroidism (HP:0000829)	1.95358321
82	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.95322242
83	Abnormality of femoral epiphyses (HP:0006499)	1.95322242
84	Abnormal connection of the cardiac segments (HP:0011545)	1.94824208
85	Abnormal ventriculo-arterial connection (HP:0011563)	1.94824208
86	Transposition of the great arteries (HP:0001669)	1.94824208
87	Focal segmental glomerulosclerosis (HP:0000097)	1.94556448
88	Abnormality of the hepatic vasculature (HP:0006707)	1.91731640
89	Flat capital femoral epiphysis (HP:0003370)	1.90178617
90	Atelectasis (HP:0100750)	1.89337881
91	Renovascular hypertension (HP:0100817)	1.87757603
92	Abnormality of the femoral head (HP:0003368)	1.86733076
93	Menstrual irregularities (HP:0000858)	1.85329111
94	Neoplasm of the heart (HP:0100544)	1.85328861
95	Bowel incontinence (HP:0002607)	1.84370658
96	Hypophosphatemic rickets (HP:0004912)	1.81191692
97	Chronic bronchitis (HP:0004469)	1.80886351
98	Peripheral hypomyelination (HP:0007182)	1.80425961
99	Recurrent corneal erosions (HP:0000495)	1.79742389
100	Short ribs (HP:0000773)	1.76577719

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.15690832
2	TESK1	6.56050621
3	DDR2	5.21948951
4	MAP4K2	4.16700316
5	INSRR	3.69294391
6	STK38	3.32045940
7	PLK2	2.98672268
8	BRD4	2.98308115
9	PNCK	2.56403153
10	MAPK15	2.35937995
11	PRKD3	2.19454533
12	CAMK1G	2.14294599
13	STK38L	2.08215754
14	WNK1	1.98111843
15	PDPK1	1.69410986
16	MST1R	1.69077257
17	PIK3CG	1.65045008
18	PDK1	1.56344910
19	CDK12	1.42378330
20	DYRK1B	1.42314721
21	CDK7	1.37333081
22	MAP3K9	1.26685576
23	KSR2	1.18781820
24	NEK6	1.16785643
25	PTK2B	1.12717500
26	LATS2	1.05527620
27	UHMK1	0.93907377
28	CAMK1D	0.83858916
29	PRKAA2	0.75351624
30	MAP3K11	0.74581053
31	AKT3	0.73375721
32	BRAF	0.72944853
33	RPS6KA2	0.71680017
34	SIK2	0.70933036
35	PRKG2	0.70630116
36	MAP2K2	0.66143743
37	PRKG1	0.65746733
38	RPS6KA1	0.65186262
39	MAP3K2	0.64745618
40	MAP3K8	0.64670231
41	ROCK1	0.53608430
42	CDK4	0.51849413
43	CAMK1	0.50589599
44	CDK3	0.48196906
45	MUSK	0.47082669
46	GSK3B	0.46996902
47	CDK2	0.43558138
48	TYRO3	0.42232763
49	BMPR1B	0.41721949
50	MAPK1	0.41356103
51	LATS1	0.40929377
52	RPS6KC1	0.40732140
53	RPS6KL1	0.40732140
54	MAP3K1	0.40729823
55	CDK1	0.40154386
56	MTOR	0.39893334
57	CAMK4	0.39318182
58	SGK223	0.39126341
59	SGK494	0.39126341
60	WNK4	0.39058249
61	STK39	0.39016831
62	RPS6KA6	0.37803936
63	MAPK8	0.37251992
64	RIPK4	0.36139914
65	ARAF	0.33976395
66	TESK2	0.33546912
67	PRKCG	0.31103132
68	MARK1	0.30823170
69	PRKCZ	0.30562570
70	CHEK1	0.30422459
71	SGK1	0.27121730
72	BLK	0.25162013
73	MAPK10	0.25157598
74	NTRK3	0.24626490
75	MARK2	0.23705959
76	TIE1	0.23424887
77	MAPK14	0.23284359
78	IKBKB	0.22751037
79	MAPK11	0.21981786
80	PRKCB	0.21759375
81	AKT1	0.18750930
82	FER	0.17535112
83	PKN1	0.16309100
84	MET	0.15500674
85	CHUK	0.13799153
86	MAP3K4	0.13098765
87	BRSK1	0.11894131
88	OXSR1	0.11606166
89	DYRK3	0.10278212
90	MAP3K13	0.09189103
91	PRKACB	0.08567366
92	MAPK9	0.07676267
93	PRKAA1	0.07369776
94	PRKACA	0.07115790
95	MAP3K7	0.05593183
96	SGK2	0.05548809
97	TNIK	0.05154883
98	FRK	0.04737418
99	RPS6KA3	0.03963276
100	ABL2	0.03245647

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.58669925
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.31365452
3	Olfactory transduction_Homo sapiens_hsa04740	3.61487394
4	Butanoate metabolism_Homo sapiens_hsa00650	2.77966999
5	Allograft rejection_Homo sapiens_hsa05330	2.49504448
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.40646427
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.37828916
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.29408607
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.09944878
10	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.95306151
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.74272860
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.72712312
13	Viral myocarditis_Homo sapiens_hsa05416	1.71170551
14	Taste transduction_Homo sapiens_hsa04742	1.60530596
15	Type II diabetes mellitus_Homo sapiens_hsa04930	1.60302040
16	Phenylalanine metabolism_Homo sapiens_hsa00360	1.44500225
17	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.43712929
18	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.35838677
19	Fatty acid degradation_Homo sapiens_hsa00071	1.31719233
20	Arginine and proline metabolism_Homo sapiens_hsa00330	1.30656849
21	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.28022837
22	RNA transport_Homo sapiens_hsa03013	1.23169576
23	Endocytosis_Homo sapiens_hsa04144	1.22593658
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.17624931
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.15631892
26	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.09682145
27	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.01901611
28	Salivary secretion_Homo sapiens_hsa04970	0.97924869
29	Protein digestion and absorption_Homo sapiens_hsa04974	0.97532133
30	Influenza A_Homo sapiens_hsa05164	0.95002901
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94034142
32	Phototransduction_Homo sapiens_hsa04744	0.91200405
33	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.87169743
34	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86715172
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86361302
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85270462
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.79941684
38	cAMP signaling pathway_Homo sapiens_hsa04024	0.79841883
39	Arginine biosynthesis_Homo sapiens_hsa00220	0.77336632
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.76342417
41	Estrogen signaling pathway_Homo sapiens_hsa04915	0.75302357
42	Calcium signaling pathway_Homo sapiens_hsa04020	0.74581248
43	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.72432232
44	Renin-angiotensin system_Homo sapiens_hsa04614	0.71821753
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.71112500
46	Morphine addiction_Homo sapiens_hsa05032	0.70457832
47	Oocyte meiosis_Homo sapiens_hsa04114	0.70171506
48	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65218877
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61759680
50	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.60022628
51	Acute myeloid leukemia_Homo sapiens_hsa05221	0.59177531
52	Circadian entrainment_Homo sapiens_hsa04713	0.57534967
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.57491639
54	ABC transporters_Homo sapiens_hsa02010	0.56943344
55	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56268974
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55736865
57	Retinol metabolism_Homo sapiens_hsa00830	0.54366784
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53523391
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52063242
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.49993365
61	MAPK signaling pathway_Homo sapiens_hsa04010	0.49660103
62	VEGF signaling pathway_Homo sapiens_hsa04370	0.48533904
63	Nicotine addiction_Homo sapiens_hsa05033	0.47188007
64	Renin secretion_Homo sapiens_hsa04924	0.45896018
65	Insulin secretion_Homo sapiens_hsa04911	0.44238871
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.44230973
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44085415
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43747214
69	Purine metabolism_Homo sapiens_hsa00230	0.38974601
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.38903866
71	Gastric acid secretion_Homo sapiens_hsa04971	0.38828878
72	Bile secretion_Homo sapiens_hsa04976	0.37901724
73	Herpes simplex infection_Homo sapiens_hsa05168	0.37878804
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37870280
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.37361834
76	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37333017
77	mRNA surveillance pathway_Homo sapiens_hsa03015	0.34064948
78	Tight junction_Homo sapiens_hsa04530	0.33596645
79	Basal transcription factors_Homo sapiens_hsa03022	0.32795103
80	Legionellosis_Homo sapiens_hsa05134	0.31220646
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.30294665
82	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27599282
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27384178
84	Cholinergic synapse_Homo sapiens_hsa04725	0.27048555
85	Pancreatic secretion_Homo sapiens_hsa04972	0.26245586
86	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.25080147
87	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.24980465
88	Toxoplasmosis_Homo sapiens_hsa05145	0.24843084
89	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.24733903
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.24561750
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.23055129
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.22487342
93	Serotonergic synapse_Homo sapiens_hsa04726	0.21143015
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19190866
95	Long-term potentiation_Homo sapiens_hsa04720	0.18045539
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.17483551
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.14434244
98	GABAergic synapse_Homo sapiens_hsa04727	0.12119421
99	Adherens junction_Homo sapiens_hsa04520	0.11516708
100	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.11259603

FAM183BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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