FAM184B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.88760683
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37437358
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27197935
4vocalization behavior (GO:0071625)5.12122420
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.08756954
6neuron cell-cell adhesion (GO:0007158)4.95850559
7locomotory exploration behavior (GO:0035641)4.93138368
8protein localization to synapse (GO:0035418)4.91785594
9synaptic vesicle exocytosis (GO:0016079)4.88698180
10regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.77766879
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54113945
12synaptic vesicle maturation (GO:0016188)4.31435726
13exploration behavior (GO:0035640)4.27252939
14prepulse inhibition (GO:0060134)4.25234949
15regulation of glutamate receptor signaling pathway (GO:1900449)4.24733905
16G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.20264877
17glutamate receptor signaling pathway (GO:0007215)4.19210212
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.17032632
19regulation of synaptic vesicle exocytosis (GO:2000300)4.10024063
20neuron-neuron synaptic transmission (GO:0007270)4.09584863
21neurotransmitter secretion (GO:0007269)4.02652967
22serotonin metabolic process (GO:0042428)4.02155467
23regulation of synapse structural plasticity (GO:0051823)4.00367984
24glutamate secretion (GO:0014047)3.99910612
25cellular potassium ion homeostasis (GO:0030007)3.99023572
26neurotransmitter-gated ion channel clustering (GO:0072578)3.96521322
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.93236951
28cell proliferation in forebrain (GO:0021846)3.90810957
29negative regulation of cytosolic calcium ion concentration (GO:0051481)3.89724829
30synaptic transmission, glutamatergic (GO:0035249)3.89027259
31response to pheromone (GO:0019236)3.89024939
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88908460
33sulfation (GO:0051923)3.84570193
34transmission of nerve impulse (GO:0019226)3.81136965
35gamma-aminobutyric acid transport (GO:0015812)3.80632634
36striatum development (GO:0021756)3.80383910
37dendritic spine morphogenesis (GO:0060997)3.79165968
38response to histamine (GO:0034776)3.77552071
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75066059
40membrane hyperpolarization (GO:0060081)3.74635847
41primary amino compound metabolic process (GO:1901160)3.73550078
42regulation of germinal center formation (GO:0002634)3.72326882
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.70107337
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69048649
45cerebellar Purkinje cell differentiation (GO:0021702)3.68988297
46synaptic vesicle endocytosis (GO:0048488)3.65308582
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.65172740
48protein polyglutamylation (GO:0018095)3.63901108
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62770076
50adaptation of signaling pathway (GO:0023058)3.62642688
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59052986
52long-term synaptic potentiation (GO:0060291)3.56509336
53cellular response to ATP (GO:0071318)3.55675081
54negative regulation of response to food (GO:0032096)3.55408141
55negative regulation of appetite (GO:0032099)3.55408141
56synapse assembly (GO:0007416)3.55203414
57positive regulation of cardiac muscle cell differentiation (GO:2000727)3.54540826
58indolalkylamine metabolic process (GO:0006586)3.53147362
59regulation of neuronal synaptic plasticity (GO:0048168)3.49180240
60pyrimidine nucleobase catabolic process (GO:0006208)3.48338837
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.44514829
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43866812
63regulation of synaptic vesicle transport (GO:1902803)3.43460535
64innervation (GO:0060384)3.42750477
65long-term memory (GO:0007616)3.41582404
66postsynaptic membrane organization (GO:0001941)3.41358173
67negative regulation of transcription regulatory region DNA binding (GO:2000678)3.40910003
68synaptic transmission, dopaminergic (GO:0001963)3.39256622
69behavioral response to cocaine (GO:0048148)3.38938603
70neuron recognition (GO:0008038)3.37922191
71positive regulation of synapse maturation (GO:0090129)3.37604881
72regulation of postsynaptic membrane potential (GO:0060078)3.37479154
73positive regulation of membrane potential (GO:0045838)3.35265209
74presynaptic membrane assembly (GO:0097105)3.34676098
75auditory behavior (GO:0031223)3.34396145
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34138556
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33773617
78positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.31411998
79sodium ion export (GO:0071436)3.30340744
80neuronal action potential propagation (GO:0019227)3.30123474
81regulation of voltage-gated calcium channel activity (GO:1901385)3.29264988
82response to auditory stimulus (GO:0010996)3.28803466
83neurotransmitter transport (GO:0006836)3.27354233
84behavioral defense response (GO:0002209)3.23793591
85behavioral fear response (GO:0001662)3.23793591
86dendrite morphogenesis (GO:0048813)3.23744923
87layer formation in cerebral cortex (GO:0021819)3.22570471
88presynaptic membrane organization (GO:0097090)3.20909699
89cerebellar granule cell differentiation (GO:0021707)3.17712528
90membrane depolarization during action potential (GO:0086010)3.17371697
91negative regulation of systemic arterial blood pressure (GO:0003085)3.15844133
92mating behavior (GO:0007617)3.13742280
93cell migration in hindbrain (GO:0021535)3.08429746
94positive regulation of potassium ion transmembrane transport (GO:1901381)3.06704445
95adult walking behavior (GO:0007628)3.06025948
96potassium ion homeostasis (GO:0055075)3.05221647
97regulation of vesicle fusion (GO:0031338)3.04263762
98cellular anion homeostasis (GO:0030002)3.04208237
99fear response (GO:0042596)3.03373012
100axonal fasciculation (GO:0007413)3.03045511
101indole-containing compound metabolic process (GO:0042430)3.02808074
102regulation of activation of Janus kinase activity (GO:0010533)3.02756452
103synapse organization (GO:0050808)3.02389033
104regulation of memory T cell differentiation (GO:0043380)3.01274023
105startle response (GO:0001964)3.00943329
106adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.00819114
107regulation of synaptic plasticity (GO:0048167)3.00331249
108regulation of neurotransmitter secretion (GO:0046928)3.00228548
109membrane depolarization (GO:0051899)2.99835902
110learning (GO:0007612)2.99831275
111regulation of action potential (GO:0098900)2.98747143
112regulation of synaptic transmission, GABAergic (GO:0032228)2.97945574
113cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97748467
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97655507
115regulation of neurotransmitter levels (GO:0001505)2.97263656
116behavioral response to ethanol (GO:0048149)2.96764784
117regulation of synapse maturation (GO:0090128)2.96756339
118retinal rod cell development (GO:0046548)2.95565029
119regulation of membrane repolarization (GO:0060306)2.95435756
120regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.94682557
121regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.94682557
122somite development (GO:0061053)2.94371570
123detection of light stimulus involved in sensory perception (GO:0050962)2.93610100
124detection of light stimulus involved in visual perception (GO:0050908)2.93610100
125dentate gyrus development (GO:0021542)2.92729996
126dopamine receptor signaling pathway (GO:0007212)2.92534197
127endoderm formation (GO:0001706)2.88512435
128nucleobase catabolic process (GO:0046113)2.88496112
129negative regulation of mast cell activation (GO:0033004)2.87606335
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87344239
131otic vesicle formation (GO:0030916)2.86118736
132multicellular organism reproduction (GO:0032504)2.80732813
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.80608973
134positive regulation of action potential (GO:0045760)2.80125846
135positive regulation of defense response to virus by host (GO:0002230)2.79787751
136positive regulation of fatty acid oxidation (GO:0046321)2.79010241
137membrane repolarization during action potential (GO:0086011)2.77633580
138water-soluble vitamin biosynthetic process (GO:0042364)2.73470671
139regulation of sequestering of triglyceride (GO:0010889)2.73346275
140regulation of rhodopsin mediated signaling pathway (GO:0022400)2.66913785
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66817835
142parturition (GO:0007567)2.64615606
143positive regulation of fatty acid transport (GO:2000193)2.64402342
144RNA destabilization (GO:0050779)2.61837708
145regulation of acrosome reaction (GO:0060046)2.60440794
146regulation of mesoderm development (GO:2000380)2.58680913
147kynurenine metabolic process (GO:0070189)2.58577560
148negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.56550105
149regulation of glomerulus development (GO:0090192)2.56023860
150tryptophan catabolic process (GO:0006569)2.55364196
151indole-containing compound catabolic process (GO:0042436)2.55364196
152indolalkylamine catabolic process (GO:0046218)2.55364196
153regulation of skeletal muscle contraction (GO:0014819)2.55011022
154kidney morphogenesis (GO:0060993)2.54976364
155regulation of DNA endoreduplication (GO:0032875)2.54555410
156reflex (GO:0060004)2.53616424
157neuronal action potential (GO:0019228)2.53058738
158preassembly of GPI anchor in ER membrane (GO:0016254)2.52106908
159regulation of hippo signaling (GO:0035330)2.50786646
160rhodopsin mediated signaling pathway (GO:0016056)2.49780854
161regulation of female receptivity (GO:0045924)2.49142909
162synaptic transmission, cholinergic (GO:0007271)2.48053497
163multicellular organismal signaling (GO:0035637)2.45540278
164pharyngeal system development (GO:0060037)2.45325030
165response to inactivity (GO:0014854)2.43671367
166neuromuscular synaptic transmission (GO:0007274)2.43320451
167regulation of potassium ion transmembrane transport (GO:1901379)2.42657597
168limb bud formation (GO:0060174)2.42597082
169purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42108707
1703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42108707
171positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.41264651
172cellular response to interleukin-15 (GO:0071350)2.41181875
173DNA methylation involved in gamete generation (GO:0043046)2.38830186
174prostate gland growth (GO:0060736)2.37845606
175axoneme assembly (GO:0035082)2.37554561
176negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.36590366
177action potential (GO:0001508)2.36351552
178DNA deamination (GO:0045006)2.35721214
179positive regulation of icosanoid secretion (GO:0032305)2.34555248
180mitotic cell cycle arrest (GO:0071850)2.33964817
181magnesium ion transport (GO:0015693)2.33819066
182positive regulation of cell fate commitment (GO:0010455)2.32863513
183L-fucose metabolic process (GO:0042354)2.31767750
184L-fucose catabolic process (GO:0042355)2.31767750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.41735719
2GBX2_23144817_ChIP-Seq_PC3_Human3.76207006
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26067452
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99215188
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93772475
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85803569
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54086535
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.48525269
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.46311951
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45855154
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45855154
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45410680
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45004072
14DROSHA_22980978_ChIP-Seq_HELA_Human2.44303016
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42899298
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42806575
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37439860
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37304179
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29509358
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.28159040
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.21716432
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18723327
23AR_21572438_ChIP-Seq_LNCaP_Human2.14554513
24* RARB_27405468_Chip-Seq_BRAIN_Mouse2.14048442
25VDR_22108803_ChIP-Seq_LS180_Human2.13513607
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.12931159
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01542870
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98802085
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93175872
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92273190
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.90048695
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88449838
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87373410
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86378538
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83490165
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83267369
37SMAD4_21799915_ChIP-Seq_A2780_Human1.75608936
38TAF15_26573619_Chip-Seq_HEK293_Human1.72689760
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70925849
40P300_19829295_ChIP-Seq_ESCs_Human1.55559818
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52857563
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.52524096
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.52275992
44IRF1_19129219_ChIP-ChIP_H3396_Human1.51370705
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.49477380
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48384842
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.47174081
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46945799
49CBP_20019798_ChIP-Seq_JUKART_Human1.46945799
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46548176
51* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45529613
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43340542
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41869034
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39231384
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37890411
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.37708543
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37492438
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33269518
59IGF1R_20145208_ChIP-Seq_DFB_Human1.32898829
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31048577
61STAT3_23295773_ChIP-Seq_U87_Human1.30950565
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.30380539
63AR_25329375_ChIP-Seq_VCAP_Human1.30317580
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30164668
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28672525
66* RNF2_27304074_Chip-Seq_NSC_Mouse1.27766599
67BCAT_22108803_ChIP-Seq_LS180_Human1.26746611
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26645332
69AR_19668381_ChIP-Seq_PC3_Human1.25537270
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25488771
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24677647
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24656919
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23624073
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23061943
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.22456398
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22421845
77* TCF4_23295773_ChIP-Seq_U87_Human1.18884261
78FUS_26573619_Chip-Seq_HEK293_Human1.17781565
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17163912
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.16698255
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.15907996
82EWS_26573619_Chip-Seq_HEK293_Human1.15342000
83* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14363969
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13569219
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.13415111
86AHR_22903824_ChIP-Seq_MCF-7_Human1.13145807
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12984456
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12415087
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12120693
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11782527
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11782527
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11677306
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09902152
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09883999
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.09253009
96TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08425198
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.08376983
98RUNX_20019798_ChIP-Seq_JUKART_Human1.08070575
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07851369
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07259495
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.04680592
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04358249
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03950098
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03249131
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.03205046
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.03154244
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.02836822
108ZNF274_21170338_ChIP-Seq_K562_Hela1.02516580
109TP53_22573176_ChIP-Seq_HFKS_Human1.02042056
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02028007
111SMAD3_21741376_ChIP-Seq_ESCs_Human1.00833707
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.00372960
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99100370
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98909087
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98263734
116TAL1_26923725_Chip-Seq_HPCs_Mouse0.97811686
117FLI1_21867929_ChIP-Seq_TH2_Mouse0.97806479
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97769090
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97714268
120TP53_16413492_ChIP-PET_HCT116_Human0.97522630
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96742248
122KDM2B_26808549_Chip-Seq_REH_Human0.96467942
123ER_23166858_ChIP-Seq_MCF-7_Human0.95161502
124RXR_22108803_ChIP-Seq_LS180_Human0.95141352
125* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95080716
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93789480
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91792670
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91772983
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91556053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.96143806
2MP0002822_catalepsy3.80655280
3MP0003635_abnormal_synaptic_transmissio3.68934152
4MP0003880_abnormal_central_pattern3.64906352
5MP0009745_abnormal_behavioral_response3.39222195
6MP0009046_muscle_twitch3.13186046
7MP0005423_abnormal_somatic_nervous3.06973943
8MP0002063_abnormal_learning/memory/cond3.05979908
9MP0003646_muscle_fatigue3.05374598
10MP0002064_seizures3.04119666
11MP0001486_abnormal_startle_reflex3.00868682
12MP0004270_analgesia2.99398940
13MP0002572_abnormal_emotion/affect_behav2.73284087
14MP0002837_dystrophic_cardiac_calcinosis2.59731836
15MP0005551_abnormal_eye_electrophysiolog2.58836848
16MP0001984_abnormal_olfaction2.55165669
17MP0001968_abnormal_touch/_nociception2.53262645
18MP0002272_abnormal_nervous_system2.45077154
19MP0001502_abnormal_circadian_rhythm2.31974506
20MP0002876_abnormal_thyroid_physiology2.29978797
21MP0004130_abnormal_muscle_cell2.25514048
22MP0002734_abnormal_mechanical_nocicepti2.20885945
23MP0002067_abnormal_sensory_capabilities2.01034821
24MP0001501_abnormal_sleep_pattern1.93688695
25MP0001440_abnormal_grooming_behavior1.92893208
26MP0002184_abnormal_innervation1.92677015
27MP0001188_hyperpigmentation1.91755883
28MP0002557_abnormal_social/conspecific_i1.91180156
29MP0002733_abnormal_thermal_nociception1.89180556
30MP0002160_abnormal_reproductive_system1.88874823
31MP0000778_abnormal_nervous_system1.88704267
32MP0002736_abnormal_nociception_after1.88391965
33MP0006072_abnormal_retinal_apoptosis1.86046982
34MP0005646_abnormal_pituitary_gland1.82012403
35MP0002735_abnormal_chemical_nociception1.79683833
36MP0008877_abnormal_DNA_methylation1.79051974
37MP0004885_abnormal_endolymph1.75005919
38MP0008569_lethality_at_weaning1.73415099
39MP0004924_abnormal_behavior1.72667204
40MP0005386_behavior/neurological_phenoty1.72667204
41MP0001529_abnormal_vocalization1.71599804
42MP0003011_delayed_dark_adaptation1.68862608
43MP0004142_abnormal_muscle_tone1.67881926
44MP0001970_abnormal_pain_threshold1.66487941
45MP0003787_abnormal_imprinting1.64480670
46MP0009780_abnormal_chondrocyte_physiolo1.64157337
47MP0005389_reproductive_system_phenotype1.61232247
48MP0002102_abnormal_ear_morphology1.58742090
49MP0005671_abnormal_response_to1.57888171
50MP0003195_calcinosis1.56683066
51MP0002882_abnormal_neuron_morphology1.55227628
52MP0003879_abnormal_hair_cell1.49932520
53MP0000955_abnormal_spinal_cord1.48810474
54MP0005174_abnormal_tail_pigmentation1.48800055
55MP0002090_abnormal_vision1.48553048
56MP0002163_abnormal_gland_morphology1.43937013
57MP0004811_abnormal_neuron_physiology1.43192263
58MP0002909_abnormal_adrenal_gland1.43187532
59MP0005253_abnormal_eye_physiology1.42405350
60MP0005499_abnormal_olfactory_system1.39781284
61MP0005394_taste/olfaction_phenotype1.39781284
62MP0000049_abnormal_middle_ear1.38204091
63MP0006292_abnormal_olfactory_placode1.37865037
64MP0002066_abnormal_motor_capabilities/c1.36964479
65MP0000631_abnormal_neuroendocrine_gland1.36921405
66MP0003329_amyloid_beta_deposits1.31979395
67MP0002229_neurodegeneration1.24921449
68MP0002752_abnormal_somatic_nervous1.19179148
69MP0004742_abnormal_vestibular_system1.18174334
70MP0004858_abnormal_nervous_system1.16397589
71MP0002152_abnormal_brain_morphology1.16386767
72MP0003878_abnormal_ear_physiology1.15258567
73MP0005377_hearing/vestibular/ear_phenot1.15258567
74MP0001919_abnormal_reproductive_system1.12527006
75MP0009250_abnormal_appendicular_skeleto1.12512883
76MP0003633_abnormal_nervous_system1.12375490
77MP0005409_darkened_coat_color1.09394902
78MP0006276_abnormal_autonomic_nervous1.07765871
79MP0005379_endocrine/exocrine_gland_phen1.07330512
80MP0001905_abnormal_dopamine_level1.06924339
81MP0003137_abnormal_impulse_conducting1.06420654
82MP0004233_abnormal_muscle_weight1.02569499
83MP0000569_abnormal_digit_pigmentation0.99263499
84MP0005195_abnormal_posterior_eye0.98705026
85MP0002653_abnormal_ependyma_morphology0.98366781
86MP0001963_abnormal_hearing_physiology0.98019916
87MP0002928_abnormal_bile_duct0.97872306
88MP0003631_nervous_system_phenotype0.97750470
89MP0004215_abnormal_myocardial_fiber0.96800320
90MP0002069_abnormal_eating/drinking_beha0.95461356
91MP0003634_abnormal_glial_cell0.94674116
92MP0003724_increased_susceptibility_to0.93568786
93MP0005084_abnormal_gallbladder_morpholo0.93278390
94MP0001765_abnormal_ion_homeostasis0.93215015
95MP0001177_atelectasis0.93197688
96MP0004134_abnormal_chest_morphology0.93101910
97MP0003638_abnormal_response/metabolism_0.92674135
98MP0008775_abnormal_heart_ventricle0.92171446
99MP0005248_abnormal_Harderian_gland0.90838384
100MP0002638_abnormal_pupillary_reflex0.89310518
101MP0008789_abnormal_olfactory_epithelium0.88789766
102MP0008872_abnormal_physiological_respon0.87337174
103MP0005645_abnormal_hypothalamus_physiol0.87218950
104MP0004145_abnormal_muscle_electrophysio0.86297536
105MP0000013_abnormal_adipose_tissue0.85670358
106MP0000372_irregular_coat_pigmentation0.85451444
107MP0009053_abnormal_anal_canal0.83188287
108MP0003122_maternal_imprinting0.82060716
109MP0004085_abnormal_heartbeat0.81761719
110MP0010386_abnormal_urinary_bladder0.81698688
111MP0004133_heterotaxia0.81612225
112MP0000230_abnormal_systemic_arterial0.80859896
113MP0003938_abnormal_ear_development0.79824829
114MP0008875_abnormal_xenobiotic_pharmacok0.79520251
115MP0004782_abnormal_surfactant_physiolog0.79328244
116MP0003690_abnormal_glial_cell0.77508390
117MP0001485_abnormal_pinna_reflex0.77182437
118MP0005360_urolithiasis0.77175783
119MP0000026_abnormal_inner_ear0.76492684
120MP0000920_abnormal_myelination0.75921777
121MP0003252_abnormal_bile_duct0.74518849
122MP0003632_abnormal_nervous_system0.73939219
123MP0000678_abnormal_parathyroid_gland0.73518382
124MP0002938_white_spotting0.72687219
125MP0002932_abnormal_joint_morphology0.72588954
126MP0001299_abnormal_eye_distance/0.68190735
127MP0000751_myopathy0.66674370
128MP0008874_decreased_physiological_sensi0.63487927
129MP0004043_abnormal_pH_regulation0.61754040
130MP0003861_abnormal_nervous_system0.60848636
131MP0005595_abnormal_vascular_smooth0.60618103
132MP0002082_postnatal_lethality0.59551921
133MP0010770_preweaning_lethality0.59551921
134MP0010769_abnormal_survival0.57174037
135MP0001943_abnormal_respiration0.54556714
136MP0010768_mortality/aging0.54441896
137MP0001986_abnormal_taste_sensitivity0.52467239
138MP0005171_absent_coat_pigmentation0.51415444

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.73030335
2Myokymia (HP:0002411)5.59518637
3Congenital stationary night blindness (HP:0007642)5.46480318
4Febrile seizures (HP:0002373)5.05088395
5Epileptic encephalopathy (HP:0200134)4.98508487
6Focal seizures (HP:0007359)4.88910865
7Visual hallucinations (HP:0002367)4.21763112
8Abnormality of macular pigmentation (HP:0008002)4.12968416
9Absence seizures (HP:0002121)4.12019605
10Progressive cerebellar ataxia (HP:0002073)3.93935024
11Central scotoma (HP:0000603)3.92324707
12Atonic seizures (HP:0010819)3.90632768
13Congenital sensorineural hearing impairment (HP:0008527)3.81035211
14Dialeptic seizures (HP:0011146)3.71759870
15Septo-optic dysplasia (HP:0100842)3.70346514
16Abolished electroretinogram (ERG) (HP:0000550)3.52055874
17Generalized tonic-clonic seizures (HP:0002069)3.41087957
18Dysdiadochokinesis (HP:0002075)3.37203109
19Abnormality of the phalanges of the 2nd finger (HP:0009541)3.29859857
20Severe visual impairment (HP:0001141)3.29679756
21Action tremor (HP:0002345)3.25544549
22Broad-based gait (HP:0002136)3.24494148
23Attenuation of retinal blood vessels (HP:0007843)3.13403967
24Drooling (HP:0002307)3.11469791
25Excessive salivation (HP:0003781)3.11469791
26IgG deficiency (HP:0004315)3.09709459
27Agitation (HP:0000713)3.00491908
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.98840364
29Mutism (HP:0002300)2.97428277
30Hemiparesis (HP:0001269)2.96815190
31Pancreatic cysts (HP:0001737)2.95765468
32Decreased circulating renin level (HP:0003351)2.95177431
33Hyperventilation (HP:0002883)2.94025299
34Mesomelia (HP:0003027)2.93332010
35Nephronophthisis (HP:0000090)2.91635499
36Scanning speech (HP:0002168)2.88288104
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.88073061
38Gaze-evoked nystagmus (HP:0000640)2.87390128
39Supranuclear gaze palsy (HP:0000605)2.85128505
40Short tibia (HP:0005736)2.84049817
41Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.82073827
42Asplenia (HP:0001746)2.82071818
43Bony spicule pigmentary retinopathy (HP:0007737)2.77401727
44Depression (HP:0000716)2.76903654
45Pancreatic fibrosis (HP:0100732)2.76737296
46Ankle clonus (HP:0011448)2.75834711
47Pendular nystagmus (HP:0012043)2.71527651
48Dysmetria (HP:0001310)2.69948648
49Poor eye contact (HP:0000817)2.69920326
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.68798537
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.65611528
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.65059172
53Methylmalonic acidemia (HP:0002912)2.63554836
54True hermaphroditism (HP:0010459)2.62575143
55Abnormality of the renal collecting system (HP:0004742)2.59893971
56Decreased central vision (HP:0007663)2.59873983
57Impaired social interactions (HP:0000735)2.56716121
58Abnormal social behavior (HP:0012433)2.56716121
59Abnormality of the renal cortex (HP:0011035)2.56484847
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.55733389
61Scotoma (HP:0000575)2.54598762
62Abnormality of the renal medulla (HP:0100957)2.53104348
63Hemiplegia (HP:0002301)2.52156329
64Anxiety (HP:0000739)2.50621132
65Clumsiness (HP:0002312)2.50214665
66Adactyly (HP:0009776)2.50135021
67Epileptiform EEG discharges (HP:0011182)2.47649255
68Short femoral neck (HP:0100864)2.46808922
69Postural instability (HP:0002172)2.44971478
70Truncal ataxia (HP:0002078)2.44155610
71EEG with generalized epileptiform discharges (HP:0011198)2.43460711
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43041645
73Radial bowing (HP:0002986)2.41675642
74Increased corneal curvature (HP:0100692)2.40935682
75Keratoconus (HP:0000563)2.40935682
76Impaired vibration sensation in the lower limbs (HP:0002166)2.38779580
77Type II lissencephaly (HP:0007260)2.38701313
78Spastic gait (HP:0002064)2.38435360
79Neurofibrillary tangles (HP:0002185)2.38249731
80Abnormal eating behavior (HP:0100738)2.35376962
81Absent septum pellucidum (HP:0001331)2.35030490
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34774470
83Short 4th metacarpal (HP:0010044)2.34774470
84Optic nerve hypoplasia (HP:0000609)2.34648243
85Abnormality of binocular vision (HP:0011514)2.34620116
86Diplopia (HP:0000651)2.34620116
87Genetic anticipation (HP:0003743)2.31361423
88Abnormality of the middle phalanges of the toes (HP:0010183)2.28184923
89Metabolic alkalosis (HP:0200114)2.28099855
90Stomach cancer (HP:0012126)2.26881978
91Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.25447896
92Hypsarrhythmia (HP:0002521)2.24273493
93Methylmalonic aciduria (HP:0012120)2.21727013
94Short 1st metacarpal (HP:0010034)2.21723159
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.21723159
96Thyroiditis (HP:0100646)2.21529940
97Torticollis (HP:0000473)2.20869926
98Intention tremor (HP:0002080)2.20108827
99Renal cortical cysts (HP:0000803)2.17571459
100Gait imbalance (HP:0002141)2.17419360
101Molar tooth sign on MRI (HP:0002419)2.17392496
102Abnormality of midbrain morphology (HP:0002418)2.17392496
103Abnormal rod and cone electroretinograms (HP:0008323)2.15186386
104Abnormality of the corticospinal tract (HP:0002492)2.13776516
105Abnormality of salivation (HP:0100755)2.13541888
106Aplasia/Hypoplasia of the fibula (HP:0006492)2.11247473
107Dynein arm defect of respiratory motile cilia (HP:0012255)2.11140269
108Absent/shortened dynein arms (HP:0200106)2.11140269
109Hypoplasia of the ulna (HP:0003022)2.10847398
110Impaired smooth pursuit (HP:0007772)2.10814606
111Status epilepticus (HP:0002133)2.09942615
112Progressive inability to walk (HP:0002505)2.09531599
113Polyphagia (HP:0002591)2.08779999
114Prolonged QT interval (HP:0001657)2.07731062
115Small hand (HP:0200055)2.07507138
116Stereotypic behavior (HP:0000733)2.07184120
117Fibular aplasia (HP:0002990)2.06573800
118Porencephaly (HP:0002132)2.05953365
119Oligodontia (HP:0000677)2.05050444
120Amblyopia (HP:0000646)2.04946014
121Urinary bladder sphincter dysfunction (HP:0002839)2.04874214
122Syncope (HP:0001279)2.04494536
123Absent speech (HP:0001344)2.03928987
124Bradykinesia (HP:0002067)2.03332436
125Urinary urgency (HP:0000012)2.02458287
126Blue irides (HP:0000635)2.02004533
127Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.01867220
128Cerebral inclusion bodies (HP:0100314)2.01336008
129Limb dystonia (HP:0002451)2.00675562
130Thyroid-stimulating hormone excess (HP:0002925)2.00638557
131Abnormality of ocular smooth pursuit (HP:0000617)1.98618024
132Megalencephaly (HP:0001355)1.98094109
133Medial flaring of the eyebrow (HP:0010747)1.97565180
134Abnormality of the lower motor neuron (HP:0002366)1.97038406
135Abnormality of the 4th metacarpal (HP:0010012)1.95467596
136Abnormality of the septum pellucidum (HP:0007375)1.94679350
137Abnormality of the 1st metacarpal (HP:0010009)1.94469450
138Abnormality of eosinophils (HP:0001879)1.91239098
139Pachygyria (HP:0001302)1.91084266
140Volvulus (HP:0002580)1.88824635
141Severe combined immunodeficiency (HP:0004430)1.86704772
142Tented upper lip vermilion (HP:0010804)1.86683963
143Focal dystonia (HP:0004373)1.86552769
144Polydipsia (HP:0001959)1.85725142
145Abnormal drinking behavior (HP:0030082)1.85725142
146Synostosis of carpal bones (HP:0005048)1.85648058
147Hypoplasia of the uterus (HP:0000013)1.83260890
148Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83228078
149Aplasia/Hypoplasia of the hallux (HP:0008362)1.83132709
150Growth hormone deficiency (HP:0000824)1.82894803
151Conical tooth (HP:0000698)1.82590884
152Protruding tongue (HP:0010808)1.82385320
153Absent phalangeal crease (HP:0006109)1.81019190
154Duplicated collecting system (HP:0000081)1.80681150
155Fibular hypoplasia (HP:0003038)1.80672242
156Specific learning disability (HP:0001328)1.80473368
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79976924
158Neuronal loss in central nervous system (HP:0002529)1.79786648
159Abnormal ciliary motility (HP:0012262)1.78662014
160Narrow nasal bridge (HP:0000446)1.78477150
161Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.77527144
162Generalized myoclonic seizures (HP:0002123)1.77270432
163Abnormality of the 2nd finger (HP:0004100)1.77075210
164Abnormality of DNA repair (HP:0003254)1.77058267
165Inability to walk (HP:0002540)1.75683669
166Lower limb muscle weakness (HP:0007340)1.75593103
167Fetal akinesia sequence (HP:0001989)1.73778802
168Craniofacial dystonia (HP:0012179)1.71905211
169Abnormal EKG (HP:0003115)1.71688124
170Dysmetric saccades (HP:0000641)1.71460419
171Incomplete penetrance (HP:0003829)1.71288648
172Aplasia/Hypoplasia of the fovea (HP:0008060)1.70757663
173Hypoplasia of the fovea (HP:0007750)1.70757663
174Congenital primary aphakia (HP:0007707)1.70664353
175Thickened helices (HP:0000391)1.68359506
176Cone-rod dystrophy (HP:0000548)1.67707412
177Genital tract atresia (HP:0001827)1.66664021
178Choroideremia (HP:0001139)1.66442765
179Autism (HP:0000717)1.66056657
180Neoplasm of the heart (HP:0100544)1.65958719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.19930649
2MARK14.08476624
3FRK3.78716650
4EPHA43.72012014
5MAP3K93.34223277
6ADRBK23.05850745
7MAP3K42.93861962
8CASK2.75031654
9TNIK2.74852459
10NTRK22.48331739
11MINK12.45677043
12PAK62.43780724
13MAP2K22.42904688
14TLK12.31792587
15MAP4K22.30094333
16MAP2K72.23780220
17GRK62.22702223
18BCKDK2.18483831
19GRK12.13235299
20WNK42.06349269
21PRPF4B1.89800812
22OBSCN1.74952531
23PHKG21.67899328
24PHKG11.67899328
25NUAK11.62907430
26DAPK21.62357979
27ZAK1.58964519
28GRK71.53895807
29PRKD21.51673626
30KSR11.51549418
31MAPK131.47239536
32CDK51.42316199
33MAP3K131.39904362
34SGK4941.33513340
35SGK2231.33513340
36MAP2K41.33377077
37MAP3K141.32292174
38STK391.28834669
39SIK21.25339325
40PNCK1.22996052
41FES1.21864390
42KIT1.21243903
43CAMKK11.18686655
44SGK21.18379991
45NTRK11.12040137
46TAOK11.10758725
47DYRK1A1.09195520
48KSR21.05905615
49PRKCG1.05846085
50STK161.05488996
51CAMK2A1.04523184
52MUSK1.04092888
53ARAF1.03430021
54MAP3K121.03400777
55RIPK41.00376299
56STK380.98726826
57GRK50.98146972
58ADRBK10.96009588
59CAMKK20.95938368
60WNK30.95007480
61NME10.94976314
62SGK30.94047254
63IKBKB0.91710637
64PRKCQ0.90297394
65PKN10.90249508
66PRKCE0.88829539
67UHMK10.88817272
68NEK60.88508296
69PIK3CA0.87912924
70TAOK20.87327440
71PRKD30.86787839
72LMTK20.86085482
73MARK20.83851333
74SGK10.83500692
75PLK20.82600743
76CAMK2B0.80823927
77MAPK70.80625034
78RPS6KA20.79233917
79PRKCZ0.77514868
80STK110.77321104
81DAPK10.76961842
82TIE10.73511888
83AKT30.73455692
84PRKCH0.72847967
85MAPK40.72242648
86CAMK2D0.71003380
87RPS6KA60.70697673
88INSRR0.70628247
89PAK30.70431991
90MAP2K10.69418040
91WNK10.69396860
92CAMK10.69312510
93EPHB20.68743143
94ERBB30.68425946
95CDK180.68404025
96ERBB20.67172765
97CDK150.66272630
98CDK140.66150158
99SYK0.65477660
100MAP3K20.65364949
101TNK20.65108360
102SIK30.64062881
103CSNK1G20.63513329
104CAMK2G0.63162231
105MAP4K10.62959612
106BMPR20.61505267
107BMPR1B0.60798044
108PINK10.59863588
109RPS6KA30.58988170
110MAP3K70.58207739
111MAPK100.57637624
112CSNK1G10.57310926
113CDC42BPA0.56845537
114OXSR10.56591400
115MAPK150.55362145
116CDK11A0.55116301
117LATS20.54289381
118CDK30.53288200
119FGFR20.52114351
120PRKCB0.51071546
121CSNK1G30.50485500
122EPHA30.50026356
123TAOK30.49970810
124RAF10.48892151
125FYN0.48583681
126ITK0.48473478
127CLK10.48172337
128TEC0.47601385
129CAMK1G0.47529728
130IGF1R0.46699818
131CSNK1D0.46609871
132RET0.46598695
133RPS6KL10.46574852
134RPS6KC10.46574852
135PRKG10.46157682
136BRD40.45936716
137PRKCI0.45764043
138CAMK40.44875815
139MAPK120.44220723
140PRKACA0.44044960
141TXK0.43961146
142FER0.43584079
143GSK3B0.42278295
144CSNK1A10.42142303
145CDK80.41830048
146TYRO30.41675534
147PRKCA0.41608755
148DYRK20.41533576
149CCNB10.40578223
150ACVR1B0.39971687
151MAP2K60.39694109
152IKBKE0.39505543

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.17878644
2GABAergic synapse_Homo sapiens_hsa047273.18062109
3Synaptic vesicle cycle_Homo sapiens_hsa047213.00518963
4Morphine addiction_Homo sapiens_hsa050322.92155405
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90591871
6Circadian entrainment_Homo sapiens_hsa047132.68843658
7Glutamatergic synapse_Homo sapiens_hsa047242.52965557
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48944179
9Olfactory transduction_Homo sapiens_hsa047402.43579574
10Amphetamine addiction_Homo sapiens_hsa050312.12415681
11Long-term potentiation_Homo sapiens_hsa047202.04359610
12Dopaminergic synapse_Homo sapiens_hsa047282.03949165
13Cholinergic synapse_Homo sapiens_hsa047251.96410476
14Salivary secretion_Homo sapiens_hsa049701.96118461
15Insulin secretion_Homo sapiens_hsa049111.92010009
16Cocaine addiction_Homo sapiens_hsa050301.88618916
17Linoleic acid metabolism_Homo sapiens_hsa005911.84056066
18Phototransduction_Homo sapiens_hsa047441.74673230
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74401038
20Serotonergic synapse_Homo sapiens_hsa047261.73893213
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72753950
22Renin secretion_Homo sapiens_hsa049241.70156052
23Tryptophan metabolism_Homo sapiens_hsa003801.69383518
24Taste transduction_Homo sapiens_hsa047421.69346624
25Oxytocin signaling pathway_Homo sapiens_hsa049211.61677905
26Long-term depression_Homo sapiens_hsa047301.60994309
27Calcium signaling pathway_Homo sapiens_hsa040201.59683581
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.59588036
29Gastric acid secretion_Homo sapiens_hsa049711.52193057
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51504728
31Circadian rhythm_Homo sapiens_hsa047101.50875934
32Primary immunodeficiency_Homo sapiens_hsa053401.50009707
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49114592
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.44226416
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43496230
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42205693
37Collecting duct acid secretion_Homo sapiens_hsa049661.41570367
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41249882
39cAMP signaling pathway_Homo sapiens_hsa040241.30635140
40Gap junction_Homo sapiens_hsa045401.27981598
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25998098
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24396844
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24211773
44Retinol metabolism_Homo sapiens_hsa008301.24127830
45GnRH signaling pathway_Homo sapiens_hsa049121.21606375
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21603960
47Chemical carcinogenesis_Homo sapiens_hsa052041.20632396
48Basal transcription factors_Homo sapiens_hsa030221.15809728
49Cardiac muscle contraction_Homo sapiens_hsa042601.13685594
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12449938
51Axon guidance_Homo sapiens_hsa043601.11919600
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11238569
53Type II diabetes mellitus_Homo sapiens_hsa049301.10562502
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07124389
55Caffeine metabolism_Homo sapiens_hsa002321.03108227
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99390136
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99057201
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96538697
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96150911
60Graft-versus-host disease_Homo sapiens_hsa053320.93926790
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93665457
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.92052265
63ErbB signaling pathway_Homo sapiens_hsa040120.91779126
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.90914882
65Dilated cardiomyopathy_Homo sapiens_hsa054140.90829191
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89366089
67Estrogen signaling pathway_Homo sapiens_hsa049150.88031236
68Ether lipid metabolism_Homo sapiens_hsa005650.87574407
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84586997
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82057865
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81517515
72Vitamin digestion and absorption_Homo sapiens_hsa049770.81467907
73Dorso-ventral axis formation_Homo sapiens_hsa043200.81214975
74Sulfur metabolism_Homo sapiens_hsa009200.80743081
75Melanogenesis_Homo sapiens_hsa049160.79930745
76Arachidonic acid metabolism_Homo sapiens_hsa005900.78924685
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78820109
78Butanoate metabolism_Homo sapiens_hsa006500.76268478
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75099614
80Glioma_Homo sapiens_hsa052140.75054561
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.74678543
82Vibrio cholerae infection_Homo sapiens_hsa051100.74382451
83MAPK signaling pathway_Homo sapiens_hsa040100.72223516
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71975146
85ABC transporters_Homo sapiens_hsa020100.70544325
86Glycerolipid metabolism_Homo sapiens_hsa005610.69905997
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69627395
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67107481
89Asthma_Homo sapiens_hsa053100.65774323
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.65726251
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65517067
92Alcoholism_Homo sapiens_hsa050340.64224564
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63983697
94Pancreatic secretion_Homo sapiens_hsa049720.63356461
95Sulfur relay system_Homo sapiens_hsa041220.62438262
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60421448
97Thyroid hormone synthesis_Homo sapiens_hsa049180.60180235
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58795583
99beta-Alanine metabolism_Homo sapiens_hsa004100.58595201
100Choline metabolism in cancer_Homo sapiens_hsa052310.56781478
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55996933
102Melanoma_Homo sapiens_hsa052180.53407794
103Type I diabetes mellitus_Homo sapiens_hsa049400.53241720
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53197997
105Ras signaling pathway_Homo sapiens_hsa040140.52749858
106Fatty acid biosynthesis_Homo sapiens_hsa000610.52420337
107T cell receptor signaling pathway_Homo sapiens_hsa046600.52373184
108Rap1 signaling pathway_Homo sapiens_hsa040150.51362626
109Oxidative phosphorylation_Homo sapiens_hsa001900.49725814
110mTOR signaling pathway_Homo sapiens_hsa041500.49656272
111Autoimmune thyroid disease_Homo sapiens_hsa053200.47213900
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47124893
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46559785
114Hedgehog signaling pathway_Homo sapiens_hsa043400.46364199
115Inositol phosphate metabolism_Homo sapiens_hsa005620.45788490
116Oocyte meiosis_Homo sapiens_hsa041140.45429991
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44969276
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44844290
119Peroxisome_Homo sapiens_hsa041460.43108756
120Renal cell carcinoma_Homo sapiens_hsa052110.43085205
121Allograft rejection_Homo sapiens_hsa053300.42493996
122Fat digestion and absorption_Homo sapiens_hsa049750.41629603
123Glucagon signaling pathway_Homo sapiens_hsa049220.40865713
124Bile secretion_Homo sapiens_hsa049760.40388292
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38573843
126Wnt signaling pathway_Homo sapiens_hsa043100.38094589
127RNA degradation_Homo sapiens_hsa030180.38020208
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37501195
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.37219561
130Endometrial cancer_Homo sapiens_hsa052130.36031228
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35880936
132Ovarian steroidogenesis_Homo sapiens_hsa049130.34986114
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34199359
134Rheumatoid arthritis_Homo sapiens_hsa053230.33407200
135Alzheimers disease_Homo sapiens_hsa050100.31205332
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30736051
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.30080597
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.29802931
139Nitrogen metabolism_Homo sapiens_hsa009100.29589602
140Endocytosis_Homo sapiens_hsa041440.28752897
141Mineral absorption_Homo sapiens_hsa049780.24420464
142Chemokine signaling pathway_Homo sapiens_hsa040620.23941955
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.21728741
144Colorectal cancer_Homo sapiens_hsa052100.21447412
145Non-small cell lung cancer_Homo sapiens_hsa052230.21214793
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20864916

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