FAM185A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)6.55636738
2pteridine-containing compound biosynthetic process (GO:0042559)4.86850646
3negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.28705124
4DNA unwinding involved in DNA replication (GO:0006268)4.09495399
5resolution of meiotic recombination intermediates (GO:0000712)3.98716035
6synapsis (GO:0007129)3.84928988
7negative regulation of DNA recombination (GO:0045910)3.81326998
8DNA deamination (GO:0045006)3.72137143
9oxaloacetate metabolic process (GO:0006107)3.71313132
10nucleobase biosynthetic process (GO:0046112)3.68234446
11IMP biosynthetic process (GO:0006188)3.67436135
12IMP metabolic process (GO:0046040)3.58170353
13regulation of translational termination (GO:0006449)3.57458779
14ribosome assembly (GO:0042255)3.52967455
15DNA replication initiation (GO:0006270)3.52131615
16CENP-A containing nucleosome assembly (GO:0034080)3.51301696
17regulation of feeding behavior (GO:0060259)3.47727632
18folic acid metabolic process (GO:0046655)3.46673654
19rRNA modification (GO:0000154)3.45557229
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.44898307
21NADH dehydrogenase complex assembly (GO:0010257)3.44898307
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44898307
23DNA double-strand break processing (GO:0000729)3.41993523
24ribosome biogenesis (GO:0042254)3.39944675
25peptidyl-lysine dimethylation (GO:0018027)3.38553074
26rRNA methylation (GO:0031167)3.35391513
27microtubule depolymerization (GO:0007019)3.34115356
28protein complex biogenesis (GO:0070271)3.31834580
29translational elongation (GO:0006414)3.30613435
30tetrahydrofolate metabolic process (GO:0046653)3.29915121
31tricarboxylic acid cycle (GO:0006099)3.29158863
32DNA topological change (GO:0006265)3.25764133
33pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.24548048
34centriole replication (GO:0007099)3.24384198
35establishment of integrated proviral latency (GO:0075713)3.22789161
36purine nucleobase biosynthetic process (GO:0009113)3.21185674
37mitotic spindle assembly checkpoint (GO:0007094)3.20794860
38negative regulation of mitotic sister chromatid separation (GO:2000816)3.20007264
39negative regulation of sister chromatid segregation (GO:0033046)3.20007264
40negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20007264
41negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20007264
42negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20007264
43spindle checkpoint (GO:0031577)3.19995130
44protein complex localization (GO:0031503)3.19857583
45mitochondrial respiratory chain complex assembly (GO:0033108)3.19044155
46valine metabolic process (GO:0006573)3.18952500
47regulation of mitochondrial translation (GO:0070129)3.18587014
48regulation of DNA endoreduplication (GO:0032875)3.17551346
49organelle disassembly (GO:1903008)3.15890640
50mitotic spindle checkpoint (GO:0071174)3.15204167
51spindle assembly checkpoint (GO:0071173)3.13856097
52translational termination (GO:0006415)3.13633856
53respiratory chain complex IV assembly (GO:0008535)3.12947058
54replication fork processing (GO:0031297)3.12337248
55DNA replication-independent nucleosome organization (GO:0034724)3.12308624
56DNA replication-independent nucleosome assembly (GO:0006336)3.12308624
57viral transcription (GO:0019083)3.11319142
58negative regulation of chromosome segregation (GO:0051985)3.11026032
59pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.09897984
60one-carbon metabolic process (GO:0006730)3.08983660
61ribosomal large subunit biogenesis (GO:0042273)3.08309512
62chaperone-mediated protein complex assembly (GO:0051131)3.08018361
63DNA ligation (GO:0006266)3.07675756
64NADH metabolic process (GO:0006734)3.05761942
65succinate metabolic process (GO:0006105)3.05557593
66pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05403185
67formation of translation preinitiation complex (GO:0001731)3.02925088
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01351777
69folic acid-containing compound metabolic process (GO:0006760)2.99374121
70regulation of centriole replication (GO:0046599)2.98446939
71oxidative phosphorylation (GO:0006119)2.97696078
72neural tube formation (GO:0001841)2.96436756
73DNA strand elongation involved in DNA replication (GO:0006271)2.96376208
74pseudouridine synthesis (GO:0001522)2.95534078
75maturation of SSU-rRNA (GO:0030490)2.95310402
762-oxoglutarate metabolic process (GO:0006103)2.94375076
77double-strand break repair via nonhomologous end joining (GO:0006303)2.93854251
78non-recombinational repair (GO:0000726)2.93854251
79sister chromatid segregation (GO:0000819)2.93426511
80pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.93232628
81UMP metabolic process (GO:0046049)2.93232628
82pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.93232628
83UMP biosynthetic process (GO:0006222)2.93232628
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92637187
85regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92637187
86metaphase plate congression (GO:0051310)2.90087749
87regulation of glucokinase activity (GO:0033131)2.89421776
88regulation of hexokinase activity (GO:1903299)2.89421776
89SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89076166
90kinetochore organization (GO:0051383)2.89001555
91translational initiation (GO:0006413)2.88899333
92mitotic nuclear envelope disassembly (GO:0007077)2.88680916
93mitochondrial DNA replication (GO:0006264)2.88336820
94glycine metabolic process (GO:0006544)2.87222916
95ribonucleoprotein complex biogenesis (GO:0022613)2.87104197
96ribonucleoprotein complex disassembly (GO:0032988)2.86717847
97histone H2A acetylation (GO:0043968)2.86443072
98regulation of sister chromatid segregation (GO:0033045)2.86268749
99regulation of mitotic sister chromatid separation (GO:0010965)2.86268749
100regulation of mitotic sister chromatid segregation (GO:0033047)2.86268749
101ribosomal small subunit assembly (GO:0000028)2.84247871
102peptidyl-arginine omega-N-methylation (GO:0035247)2.81456639
103cotranslational protein targeting to membrane (GO:0006613)2.80697962
104protein targeting to ER (GO:0045047)2.80339530
105microtubule anchoring (GO:0034453)2.80292699
106histone exchange (GO:0043486)2.80039695
107pteridine-containing compound metabolic process (GO:0042558)2.77670426
108positive regulation of mitochondrial fission (GO:0090141)2.77023489
109protein localization to kinetochore (GO:0034501)2.76595765
110pre-miRNA processing (GO:0031054)2.76264795
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75762406
112regulation of mitotic spindle checkpoint (GO:1903504)2.75762406
113mitotic metaphase plate congression (GO:0007080)2.75688464
114pyrimidine nucleobase catabolic process (GO:0006208)2.74942908
115DNA strand elongation (GO:0022616)2.74704733
116tricarboxylic acid metabolic process (GO:0072350)2.74533413
117telomere maintenance via semi-conservative replication (GO:0032201)2.74164580
118reciprocal DNA recombination (GO:0035825)2.74036302
119reciprocal meiotic recombination (GO:0007131)2.74036302
120mitochondrial DNA metabolic process (GO:0032042)2.74007835
121nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73821772
122membrane disassembly (GO:0030397)2.73650159
123nuclear envelope disassembly (GO:0051081)2.73650159
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.72928646
125nonmotile primary cilium assembly (GO:0035058)2.72403471
126rRNA processing (GO:0006364)2.71451290
127protein localization to endoplasmic reticulum (GO:0070972)2.70031260
128protein localization to chromosome, centromeric region (GO:0071459)2.69550232
129kinetochore assembly (GO:0051382)2.69075921
130regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68379711
131protein K6-linked ubiquitination (GO:0085020)2.68185172
132mitotic sister chromatid segregation (GO:0000070)2.66923399
133protein localization to chromosome (GO:0034502)2.66747140
134establishment of mitochondrion localization (GO:0051654)2.66660572
135protein K11-linked ubiquitination (GO:0070979)2.66362866
136pyrimidine dimer repair (GO:0006290)2.66207158
137tRNA aminoacylation for protein translation (GO:0006418)2.65855589
138iron-sulfur cluster assembly (GO:0016226)2.65259250
139metallo-sulfur cluster assembly (GO:0031163)2.65259250
140centriole assembly (GO:0098534)2.64122680
141amino acid activation (GO:0043038)2.64013628
142tRNA aminoacylation (GO:0043039)2.64013628
143rRNA metabolic process (GO:0016072)2.63447900
144rRNA transcription (GO:0009303)2.63096125
145DNA replication-dependent nucleosome assembly (GO:0006335)2.63070455
146DNA replication-dependent nucleosome organization (GO:0034723)2.63070455
147peptidyl-arginine methylation (GO:0018216)2.62124783
148peptidyl-arginine N-methylation (GO:0035246)2.62124783
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.61537000
150regulation of chromosome segregation (GO:0051983)2.60957302
151mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60933213
152chaperone-mediated protein transport (GO:0072321)2.60912430
153regulation of coenzyme metabolic process (GO:0051196)2.60633511
154regulation of cofactor metabolic process (GO:0051193)2.60633511
155galactose catabolic process (GO:0019388)2.59795439
156pyrimidine nucleotide catabolic process (GO:0006244)2.59427592
157maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58224431
158mannosylation (GO:0097502)2.58099164
159negative regulation of histone methylation (GO:0031061)2.56819571
160protein maturation by protein folding (GO:0022417)2.56080545
161chromatin remodeling at centromere (GO:0031055)2.54759454
162COPI coating of Golgi vesicle (GO:0048205)2.54678534
163Golgi transport vesicle coating (GO:0048200)2.54678534
164positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.54657433
165mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.54657433
166regulation of double-strand break repair via homologous recombination (GO:0010569)2.52833991
167regulation of cilium movement (GO:0003352)2.52143731
168lysine metabolic process (GO:0006553)2.52098328
169lysine catabolic process (GO:0006554)2.52098328
170anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51635703
171histone arginine methylation (GO:0034969)2.51172541
172proteasome assembly (GO:0043248)2.50536441
173RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.48939225
174regulation of translational fidelity (GO:0006450)2.48774860
175regulation of penile erection (GO:0060405)2.48531993
176regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.48521190
177regulation of centrosome cycle (GO:0046605)2.48430907
178peptidyl-histidine modification (GO:0018202)2.47670819
179DNA replication checkpoint (GO:0000076)2.47497350
180regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.45995512
181negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.45888378
182cellular protein complex disassembly (GO:0043624)2.44749607
183negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44746647
184regulation of centrosome duplication (GO:0010824)2.44739541
185negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.44591265
186somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44497818
187somatic hypermutation of immunoglobulin genes (GO:0016446)2.44497818
188regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.44233523
189nuclear pore organization (GO:0006999)2.44104651
190nucleotide salvage (GO:0043173)2.43807974
191nuclear pore complex assembly (GO:0051292)2.43164571
192nucleoside salvage (GO:0043174)2.42082283
193regulation of acyl-CoA biosynthetic process (GO:0050812)2.41522504
194translation (GO:0006412)2.41079133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13299381
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.54118331
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.08959257
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.44990048
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25369241
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99211654
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85291363
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85161310
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79410393
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76723281
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67703998
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66764761
13IGF1R_20145208_ChIP-Seq_DFB_Human2.61965842
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.55988668
15TAF15_26573619_Chip-Seq_HEK293_Human2.54214349
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.53726303
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45860617
18EWS_26573619_Chip-Seq_HEK293_Human2.45836932
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45752840
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.39658638
21MYC_22102868_ChIP-Seq_BL_Human2.38786716
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36952081
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.31329420
24FUS_26573619_Chip-Seq_HEK293_Human2.29017201
25VDR_22108803_ChIP-Seq_LS180_Human2.25739028
26GBX2_23144817_ChIP-Seq_PC3_Human2.22247880
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.21788715
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18794130
29FOXP3_21729870_ChIP-Seq_TREG_Human2.16155404
30VDR_23849224_ChIP-Seq_CD4+_Human2.15805935
31XRN2_22483619_ChIP-Seq_HELA_Human2.10807588
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07890515
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07812162
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06319942
35ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06233430
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03111921
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02537064
38GATA1_22025678_ChIP-Seq_K562_Human2.01456905
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99086553
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94335962
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94029109
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91793801
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89004260
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88809772
45GABP_19822575_ChIP-Seq_HepG2_Human1.87282402
46DCP1A_22483619_ChIP-Seq_HELA_Human1.83381347
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81429736
48ZNF263_19887448_ChIP-Seq_K562_Human1.80921329
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79410640
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78674662
51CIITA_25753668_ChIP-Seq_RAJI_Human1.73777135
52* ER_23166858_ChIP-Seq_MCF-7_Human1.72125119
53IRF1_19129219_ChIP-ChIP_H3396_Human1.71501763
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69956376
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67519615
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67053464
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66116344
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64693108
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.64666577
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64261840
61TTF2_22483619_ChIP-Seq_HELA_Human1.60219843
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59606272
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57937409
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57579812
65* P300_19829295_ChIP-Seq_ESCs_Human1.57043606
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51359394
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50415412
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.50249297
69* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50008716
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48799986
71KDM5A_27292631_Chip-Seq_BREAST_Human1.46019112
72AR_21909140_ChIP-Seq_LNCAP_Human1.44713317
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44421646
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43855979
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43807629
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42609996
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38990938
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38931218
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38331900
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36155805
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35031079
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34142530
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.33257557
84* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33040826
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32695912
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31116136
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30857325
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30660733
89RNF2_27304074_Chip-Seq_NSC_Mouse1.29831654
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29118429
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28454662
92* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28076868
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27624541
94SMAD4_21799915_ChIP-Seq_A2780_Human1.26498115
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24678322
96EZH2_22144423_ChIP-Seq_EOC_Human1.24301908
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21407642
98MYC_18940864_ChIP-ChIP_HL60_Human1.19205434
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18705865
100* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18567291
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.18402245
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17098024
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16316585
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15811955
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14221342
106EGR1_19374776_ChIP-ChIP_THP-1_Human1.13894164
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12730216
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.11076809
109TP53_22573176_ChIP-Seq_HFKS_Human1.10665093
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10505244
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10281335
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10099533
113CBP_20019798_ChIP-Seq_JUKART_Human1.09573655
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09573655
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08989557
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07958868
117TFEB_21752829_ChIP-Seq_HELA_Human1.07709564
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06414561
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06039134
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05731958
121STAT3_23295773_ChIP-Seq_U87_Human1.04245599
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01850813
123TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01075948
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99381168
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99356698
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98743994
127TCF4_23295773_ChIP-Seq_U87_Human0.97932731
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97837472
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96842220
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96766609
131AR_25329375_ChIP-Seq_VCAP_Human0.96593093
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.96129835
133YY1_21170310_ChIP-Seq_MESCs_Mouse0.96028463
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95959645
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95672169
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95590864
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94989394
138PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93692683
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93440239
140ZNF274_21170338_ChIP-Seq_K562_Hela0.93232863
141TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92998490
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92422564
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90916546
144RXR_22158963_ChIP-Seq_LIVER_Mouse0.90257116
145ELK1_19687146_ChIP-ChIP_HELA_Human0.89804782
146CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89444881
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89388299
148CHD1_26751641_Chip-Seq_LNCaP_Human0.85246624
149GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85169706
150HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84897295
151CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83624753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.06345840
2MP0002139_abnormal_hepatobiliary_system2.87317846
3MP0008057_abnormal_DNA_replication2.84105901
4MP0004957_abnormal_blastocyst_morpholog2.81933142
5MP0003806_abnormal_nucleotide_metabolis2.81052941
6MP0008877_abnormal_DNA_methylation2.79468487
7MP0003646_muscle_fatigue2.61949384
8MP0006036_abnormal_mitochondrial_physio2.60418596
9MP0002837_dystrophic_cardiac_calcinosis2.60263476
10MP0003880_abnormal_central_pattern2.57018920
11MP0005365_abnormal_bile_salt2.48768065
12MP0003123_paternal_imprinting2.45323575
13MP0003121_genomic_imprinting2.32312677
14MP0009697_abnormal_copulation2.27436809
15MP0000569_abnormal_digit_pigmentation2.25924538
16MP0002396_abnormal_hematopoietic_system2.22018472
17MP0005085_abnormal_gallbladder_physiolo2.15960897
18MP0003787_abnormal_imprinting2.14455341
19MP0002102_abnormal_ear_morphology2.14027939
20MP0010094_abnormal_chromosome_stability2.13406651
21MP0001984_abnormal_olfaction2.09770129
22MP0003077_abnormal_cell_cycle2.06595809
23MP0008058_abnormal_DNA_repair2.06226526
24MP0008995_early_reproductive_senescence2.02039731
25MP0001730_embryonic_growth_arrest1.94765608
26MP0002877_abnormal_melanocyte_morpholog1.90049827
27MP0006035_abnormal_mitochondrial_morpho1.88781980
28MP0005360_urolithiasis1.85533757
29MP0003111_abnormal_nucleus_morphology1.78789190
30MP0003786_premature_aging1.78786694
31MP0008789_abnormal_olfactory_epithelium1.78343794
32MP0004233_abnormal_muscle_weight1.73829400
33MP0002693_abnormal_pancreas_physiology1.73072990
34MP0000778_abnormal_nervous_system1.72865258
35MP0010352_gastrointestinal_tract_polyps1.72009904
36MP0002269_muscular_atrophy1.69768383
37MP0002638_abnormal_pupillary_reflex1.68855940
38MP0005499_abnormal_olfactory_system1.67232319
39MP0005394_taste/olfaction_phenotype1.67232319
40MP0001188_hyperpigmentation1.65778721
41MP0004215_abnormal_myocardial_fiber1.65632517
42MP0004145_abnormal_muscle_electrophysio1.65615901
43MP0005645_abnormal_hypothalamus_physiol1.65043417
44MP0001764_abnormal_homeostasis1.61803816
45MP0003718_maternal_effect1.57953282
46MP0002234_abnormal_pharynx_morphology1.55519002
47MP0001944_abnormal_pancreas_morphology1.54966984
48MP0003300_gastrointestinal_ulcer1.52116472
49MP0000747_muscle_weakness1.51334187
50MP0006276_abnormal_autonomic_nervous1.49809302
51MP0003221_abnormal_cardiomyocyte_apopto1.49729144
52MP0003122_maternal_imprinting1.49595289
53MP0003567_abnormal_fetal_cardiomyocyte1.49295387
54MP0005266_abnormal_metabolism1.48122585
55MP0008875_abnormal_xenobiotic_pharmacok1.45972841
56MP0001293_anophthalmia1.43444049
57MP0005551_abnormal_eye_electrophysiolog1.42398905
58MP0004142_abnormal_muscle_tone1.40573499
59MP0003868_abnormal_feces_composition1.40251263
60MP0005253_abnormal_eye_physiology1.36875240
61MP0005423_abnormal_somatic_nervous1.31862143
62MP0000751_myopathy1.31229469
63MP0006292_abnormal_olfactory_placode1.29132863
64MP0000350_abnormal_cell_proliferation1.28141171
65MP0004147_increased_porphyrin_level1.27406261
66MP0002078_abnormal_glucose_homeostasis1.26748528
67MP0003866_abnormal_defecation1.25740089
68MP0005187_abnormal_penis_morphology1.25378900
69MP0000609_abnormal_liver_physiology1.25137923
70MP0000358_abnormal_cell_content/1.24874045
71MP0009046_muscle_twitch1.24660073
72MP0005330_cardiomyopathy1.24213053
73MP0005220_abnormal_exocrine_pancreas1.22774020
74MP0001697_abnormal_embryo_size1.17584450
75MP0002735_abnormal_chemical_nociception1.17511293
76MP0002080_prenatal_lethality1.15599991
77MP0002751_abnormal_autonomic_nervous1.14949580
78MP0002184_abnormal_innervation1.14542887
79MP0004084_abnormal_cardiac_muscle1.14503242
80MP0004036_abnormal_muscle_relaxation1.12385220
81MP0008007_abnormal_cellular_replicative1.11922659
82MP0003890_abnormal_embryonic-extraembry1.10309194
83MP0000490_abnormal_crypts_of1.09889730
84MP0002909_abnormal_adrenal_gland1.09799565
85MP0002019_abnormal_tumor_incidence1.09607374
86MP0004133_heterotaxia1.08157364
87MP0004859_abnormal_synaptic_plasticity1.07058707
88MP0002272_abnormal_nervous_system1.06974870
89MP0000427_abnormal_hair_cycle1.04975241
90MP0002928_abnormal_bile_duct1.01811746
91MP0005319_abnormal_enzyme/_coenzyme1.01766049
92MP0003698_abnormal_male_reproductive1.00471503
93MP0009840_abnormal_foam_cell0.99863287
94MP0001929_abnormal_gametogenesis0.99839107
95MP0005389_reproductive_system_phenotype0.99778450
96MP0010307_abnormal_tumor_latency0.99509240
97MP0002736_abnormal_nociception_after0.98814803
98MP0001286_abnormal_eye_development0.98413711
99MP0000631_abnormal_neuroendocrine_gland0.97936568
100MP0002822_catalepsy0.97722634
101MP0003984_embryonic_growth_retardation0.96888095
102MP0004808_abnormal_hematopoietic_stem0.96608565
103MP0003635_abnormal_synaptic_transmissio0.96302314
104MP0010329_abnormal_lipoprotein_level0.96276116
105MP0005386_behavior/neurological_phenoty0.95817593
106MP0004924_abnormal_behavior0.95817593
107MP0000313_abnormal_cell_death0.95674929
108MP0001545_abnormal_hematopoietic_system0.95086722
109MP0005397_hematopoietic_system_phenotyp0.95086722
110MP0002088_abnormal_embryonic_growth/wei0.94648426
111MP0005646_abnormal_pituitary_gland0.93153156
112MP0000647_abnormal_sebaceous_gland0.92891246
113MP0005636_abnormal_mineral_homeostasis0.92405291
114MP0005391_vision/eye_phenotype0.91922910
115MP0010386_abnormal_urinary_bladder0.91773876
116MP0001672_abnormal_embryogenesis/_devel0.91176164
117MP0005380_embryogenesis_phenotype0.91176164
118MP0002095_abnormal_skin_pigmentation0.90595010
119MP0005535_abnormal_body_temperature0.89439065
120MP0002084_abnormal_developmental_patter0.88620210
121MP0003763_abnormal_thymus_physiology0.88398641
122MP0000703_abnormal_thymus_morphology0.87219403
123MP0008872_abnormal_physiological_respon0.86492521
124MP0001968_abnormal_touch/_nociception0.85911910
125MP0000372_irregular_coat_pigmentation0.85682756
126MP0002752_abnormal_somatic_nervous0.85579943
127MP0004130_abnormal_muscle_cell0.85427144
128MP0005584_abnormal_enzyme/coenzyme_acti0.85335670
129MP0003252_abnormal_bile_duct0.84929396
130MP0008932_abnormal_embryonic_tissue0.84659230
131MP0002086_abnormal_extraembryonic_tissu0.83956583
132MP0000598_abnormal_liver_morphology0.83675863
133MP0005332_abnormal_amino_acid0.83193132
134MP0004811_abnormal_neuron_physiology0.82687674
135MP0002067_abnormal_sensory_capabilities0.82365208
136MP0004270_analgesia0.81707190
137MP0001324_abnormal_eye_pigmentation0.81646927
138MP0000955_abnormal_spinal_cord0.81448355
139MP0002233_abnormal_nose_morphology0.80894553
140MP0009745_abnormal_behavioral_response0.80612452
141MP0003283_abnormal_digestive_organ0.79849069
142MP0005084_abnormal_gallbladder_morpholo0.79383426
143MP0002734_abnormal_mechanical_nocicepti0.78629240
144MP0010234_abnormal_vibrissa_follicle0.77904106
145MP0002106_abnormal_muscle_physiology0.77717315
146MP0001145_abnormal_male_reproductive0.77058556
147MP0006072_abnormal_retinal_apoptosis0.76809011
148MP0001986_abnormal_taste_sensitivity0.76395500
149MP0004087_abnormal_muscle_fiber0.76378073
150MP0000653_abnormal_sex_gland0.76146620
151MP0005195_abnormal_posterior_eye0.75446236
152MP0001485_abnormal_pinna_reflex0.75028613
153MP0002882_abnormal_neuron_morphology0.74889717
154MP0003861_abnormal_nervous_system0.74811872
155MP0000689_abnormal_spleen_morphology0.74654725
156MP0002398_abnormal_bone_marrow0.74538835
157MP0004197_abnormal_fetal_growth/weight/0.74360373
158MP0001529_abnormal_vocalization0.73864961
159MP0005376_homeostasis/metabolism_phenot0.73689778
160MP0002210_abnormal_sex_determination0.73546063
161MP0001666_abnormal_nutrient_absorption0.73362366
162MP0002152_abnormal_brain_morphology0.72807823
163MP0002063_abnormal_learning/memory/cond0.72657526
164MP0008770_decreased_survivor_rate0.72381001
165MP0004043_abnormal_pH_regulation0.72167533
166MP0009672_abnormal_birth_weight0.72104713
167MP0002653_abnormal_ependyma_morphology0.72098878
168MP0002160_abnormal_reproductive_system0.71666760

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)3.93601488
2Aplastic anemia (HP:0001915)3.88110361
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.84771295
4Volvulus (HP:0002580)3.79222161
5Ketoacidosis (HP:0001993)3.45620435
6Myoglobinuria (HP:0002913)3.45476222
7Hyperinsulinemic hypoglycemia (HP:0000825)3.25306736
8Progressive muscle weakness (HP:0003323)3.12050872
9Nephrogenic diabetes insipidus (HP:0009806)3.11716112
10Abnormality of alanine metabolism (HP:0010916)3.09971152
11Hyperalaninemia (HP:0003348)3.09971152
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09971152
13True hermaphroditism (HP:0010459)3.05576083
14Medial flaring of the eyebrow (HP:0010747)3.02357678
15Pancreatic fibrosis (HP:0100732)3.00205072
16Gait imbalance (HP:0002141)2.96256471
17Congenital primary aphakia (HP:0007707)2.95440677
18Ketosis (HP:0001946)2.91000308
19Pancreatic cysts (HP:0001737)2.85543730
20Abnormality of cells of the erythroid lineage (HP:0012130)2.85347735
21Retinal dysplasia (HP:0007973)2.81166034
22Molar tooth sign on MRI (HP:0002419)2.80419224
23Abnormality of midbrain morphology (HP:0002418)2.80419224
24Rhabdomyolysis (HP:0003201)2.79084159
25Chronic hepatic failure (HP:0100626)2.72222304
26Poikiloderma (HP:0001029)2.70788021
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69461348
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69461348
29Hepatic necrosis (HP:0002605)2.63606598
30Genital tract atresia (HP:0001827)2.62622582
31Late onset (HP:0003584)2.61914397
32Abnormality of chromosome stability (HP:0003220)2.61315784
33Oral leukoplakia (HP:0002745)2.59115126
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.58523406
35Hypoglycemic seizures (HP:0002173)2.58032407
36Vaginal atresia (HP:0000148)2.57189991
37Dicarboxylic aciduria (HP:0003215)2.54145496
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54145496
39Hyperglycinemia (HP:0002154)2.51497737
40Abnormal number of erythroid precursors (HP:0012131)2.51113702
41Cerebral edema (HP:0002181)2.49703302
42Abnormal mitochondria in muscle tissue (HP:0008316)2.48844181
43Chronic bronchitis (HP:0004469)2.43017634
44Meckel diverticulum (HP:0002245)2.42749156
45Increased serum pyruvate (HP:0003542)2.42300861
46Abnormality of the labia minora (HP:0012880)2.39722983
47Abnormality of the ileum (HP:0001549)2.39582654
48Ragged-red muscle fibers (HP:0003200)2.38190748
49Increased intramyocellular lipid droplets (HP:0012240)2.36656831
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.33233470
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.33233470
52Hepatocellular necrosis (HP:0001404)2.30370643
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27999028
54Lactic acidosis (HP:0003128)2.26998762
55Type II lissencephaly (HP:0007260)2.24964500
56Poor coordination (HP:0002370)2.24069776
57Acute necrotizing encephalopathy (HP:0006965)2.23996539
58Chromsome breakage (HP:0040012)2.23437060
59Increased muscle lipid content (HP:0009058)2.23406356
60Abnormality of the pancreatic islet cells (HP:0006476)2.22866600
61Abnormality of endocrine pancreas physiology (HP:0012093)2.22866600
62Acute encephalopathy (HP:0006846)2.21854444
63Increased CSF lactate (HP:0002490)2.20358096
64Drooling (HP:0002307)2.19929950
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.19451155
66Increased serum lactate (HP:0002151)2.19164091
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.18223916
68Oligodactyly (hands) (HP:0001180)2.18118598
69Sloping forehead (HP:0000340)2.18028120
70Bronchitis (HP:0012387)2.17197166
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.16620030
72Limb hypertonia (HP:0002509)2.16121978
73Lissencephaly (HP:0001339)2.15476452
74Hypoplasia of the pons (HP:0012110)2.13756871
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13040758
76Thrombocytosis (HP:0001894)2.10304878
77Astigmatism (HP:0000483)2.09866891
78Tubulointerstitial nephritis (HP:0001970)2.09838049
79Abnormality of fatty-acid metabolism (HP:0004359)2.09790622
80Short tibia (HP:0005736)2.09004062
81Duodenal stenosis (HP:0100867)2.08673532
82Small intestinal stenosis (HP:0012848)2.08673532
83Rhabdomyosarcoma (HP:0002859)2.08593815
84Reduced antithrombin III activity (HP:0001976)2.08203652
85Nasal polyposis (HP:0100582)2.08021000
86Death in childhood (HP:0003819)2.06792303
87Mitochondrial inheritance (HP:0001427)2.06131009
88Hyperglycemia (HP:0003074)2.05232528
89Abnormality of glycolysis (HP:0004366)2.05158524
90Prominent nose (HP:0000448)2.03951474
91Colon cancer (HP:0003003)2.03146276
92Microretrognathia (HP:0000308)2.02905306
93Recurrent bronchitis (HP:0002837)1.99983521
94Abnormality of the preputium (HP:0100587)1.99881552
95Thyroid carcinoma (HP:0002890)1.99481703
96Exercise-induced myalgia (HP:0003738)1.99078966
97Renal cortical cysts (HP:0000803)1.98371604
98Lethargy (HP:0001254)1.97948306
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96759010
100Gaze-evoked nystagmus (HP:0000640)1.96743585
101Rhinitis (HP:0012384)1.95820277
102Excessive salivation (HP:0003781)1.93310669
103Methylmalonic aciduria (HP:0012120)1.91099172
104Symptomatic seizures (HP:0011145)1.90744544
105Impaired smooth pursuit (HP:0007772)1.90737065
106Nephronophthisis (HP:0000090)1.90324562
107Angiofibromas (HP:0010615)1.90220075
108Adenoma sebaceum (HP:0009720)1.90220075
109Entropion (HP:0000621)1.90188553
110Pallor (HP:0000980)1.89919412
111Abnormality of the intrinsic pathway (HP:0010989)1.88721653
112Prominent metopic ridge (HP:0005487)1.87191876
113Emotional lability (HP:0000712)1.87060539
114Methylmalonic acidemia (HP:0002912)1.86257467
115Myelodysplasia (HP:0002863)1.85205309
116Abnormality of the corticospinal tract (HP:0002492)1.85007869
117Hypobetalipoproteinemia (HP:0003563)1.84787807
118Abnormality of the astrocytes (HP:0100707)1.84452695
119Astrocytoma (HP:0009592)1.84452695
120Abnormality of the duodenum (HP:0002246)1.84218970
121Medulloblastoma (HP:0002885)1.83905238
122Abnormality of the pons (HP:0007361)1.83637527
123Specific learning disability (HP:0001328)1.83499385
124IgM deficiency (HP:0002850)1.83349947
125Exercise intolerance (HP:0003546)1.83251433
126Pancreatic islet-cell hyperplasia (HP:0004510)1.82960368
127Exercise-induced muscle cramps (HP:0003710)1.82319798
128Intrahepatic cholestasis (HP:0001406)1.82028935
129CNS hypomyelination (HP:0003429)1.80024035
130Progressive macrocephaly (HP:0004481)1.79728008
131Intellectual disability, profound (HP:0002187)1.79286748
132Hyperammonemia (HP:0001987)1.79002685
133CNS demyelination (HP:0007305)1.77543415
134Megaloblastic anemia (HP:0001889)1.77496396
135Esotropia (HP:0000565)1.77373366
136Abnormal lung lobation (HP:0002101)1.77248167
137Palpitations (HP:0001962)1.77084043
138Anencephaly (HP:0002323)1.76129887
139Bronchiectasis (HP:0002110)1.75962822
140Choreoathetosis (HP:0001266)1.75732899
141Bile duct proliferation (HP:0001408)1.75680200
142Abnormal biliary tract physiology (HP:0012439)1.75680200
143Lipid accumulation in hepatocytes (HP:0006561)1.74846234
144Inability to walk (HP:0002540)1.74369061
145Insulin resistance (HP:0000855)1.74237549
146Multicystic kidney dysplasia (HP:0000003)1.74158129
147Type I transferrin isoform profile (HP:0003642)1.74095280
148Abnormality of methionine metabolism (HP:0010901)1.73995638
149Male pseudohermaphroditism (HP:0000037)1.73948834
150Ependymoma (HP:0002888)1.73242672
151Abnormal respiratory motile cilium physiology (HP:0012261)1.72979251
152Renal Fanconi syndrome (HP:0001994)1.72509991
153Birth length less than 3rd percentile (HP:0003561)1.71648323
154Tachypnea (HP:0002789)1.71631805
155Aganglionic megacolon (HP:0002251)1.71513338
156Gout (HP:0001997)1.71153498
157Pelvic girdle muscle weakness (HP:0003749)1.71143472
158Papillary thyroid carcinoma (HP:0002895)1.70984957
159Bifid tongue (HP:0010297)1.70346291
160Papilledema (HP:0001085)1.70288767
161Cerebellar dysplasia (HP:0007033)1.70263845
162Brushfield spots (HP:0001088)1.70170153
163Abnormality of serum amino acid levels (HP:0003112)1.70158393
164Gastrointestinal stroma tumor (HP:0100723)1.70046789
165Narrow forehead (HP:0000341)1.69794640
166Aplasia/Hypoplasia of the sternum (HP:0006714)1.69315821
167Abnormality of the nasal mucosa (HP:0000433)1.67895517
168Absent speech (HP:0001344)1.67686960
169Visual hallucinations (HP:0002367)1.67039245
170Asymmetric septal hypertrophy (HP:0001670)1.66905361
171Sclerocornea (HP:0000647)1.66785697
172Increased hepatocellular lipid droplets (HP:0006565)1.65942996
173Multiple enchondromatosis (HP:0005701)1.65571572
174Hypothermia (HP:0002045)1.65384662
175Oligohydramnios (HP:0001562)1.65375864
176Facial cleft (HP:0002006)1.61966243
177Progressive inability to walk (HP:0002505)1.60825486
178Abnormality of serine family amino acid metabolism (HP:0010894)1.60364999
179Abnormality of glycine metabolism (HP:0010895)1.60364999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.84113259
2FLT33.72955320
3SCYL23.41956417
4INSRR3.41001344
5PKN23.14021158
6EEF2K2.79917625
7BCR2.75028796
8TRIM282.73508444
9MAP4K22.65744254
10BCKDK2.64547525
11PBK2.61211749
12WEE12.57596008
13CDC72.56495646
14NEK12.45003661
15MAP2K72.39723258
16ERBB32.34260499
17PDK42.20123630
18PDK32.20123630
19STK38L2.14051400
20RPS6KA41.87994570
21EIF2AK31.82118405
22EIF2AK11.81992919
23NEK21.80605985
24WNK31.79992858
25MAP2K41.76788755
26MARK11.67515166
27OBSCN1.66316465
28PASK1.65532959
29TNIK1.62804971
30TTK1.60630203
31STK241.58124773
32ACVR1B1.53260389
33MAP3K91.48737959
34NUAK11.46567193
35RAF11.40920439
36MUSK1.40178900
37FRK1.35976087
38CSNK1G31.34880764
39CSNK1A1L1.33434306
40CSNK1G11.32886021
41MAP4K11.31964731
42MAPK131.30585572
43TRIB31.30156988
44CSNK1G21.25855774
45ARAF1.24137596
46BRSK21.21605289
47HIPK21.20849240
48DYRK31.16413734
49NME21.15903221
50KSR21.13803373
51PLK41.13329190
52BMPR1B1.12274185
53MKNK11.12267753
54NME11.11931170
55RPS6KB21.08392443
56PAK31.07636303
57STK161.06901561
58DYRK21.05126873
59CAMKK21.02362146
60TSSK61.00749744
61MINK10.99372607
62SIK30.99367463
63CDK40.98544662
64MKNK20.97730540
65LATS20.96810199
66RET0.95911395
67NLK0.95870923
68CCNB10.95738112
69MST40.95628099
70CASK0.92866325
71KSR10.92182630
72CDK190.88622603
73PLK10.82779358
74ALK0.80218157
75MAPKAPK30.78387093
76BRAF0.77224001
77ATR0.76520630
78WNK10.73214599
79BUB10.72979771
80CAMKK10.68857375
81RPS6KA50.68597135
82MAP3K110.68550073
83AURKB0.68258872
84MAP3K80.68199212
85PNCK0.68050095
86CHEK20.67878447
87SRPK10.66978527
88MAP3K20.66342436
89AURKA0.65818070
90GRK60.62462098
91TNK20.62028798
92MAP3K60.61503158
93ERBB20.61345357
94TAOK30.60072256
95AKT30.59629855
96ERN10.59589957
97MARK30.58184439
98PRKACB0.57849814
99MAP3K50.57846960
100TESK20.57042505
101CHEK10.56696232
102TEC0.55012562
103CDK60.54857405
104CSNK2A20.54329367
105STK40.53661760
106VRK10.52287692
107CLK10.51578777
108DAPK10.51454152
109MAP3K120.51221225
110PLK20.51039026
111TGFBR10.47292199
112ZAP700.47222139
113PRKCE0.46033354
114PTK60.45902453
115CDK30.45357386
116BRSK10.44892998
117TAOK10.44499346
118MAPK150.44433310
119TTN0.44412777
120CDK10.44359525
121PDK20.44166434
122ATM0.43776334
123CDK120.43572115
124STK380.43518442
125CSNK1A10.43158744
126CSNK2A10.42356019
127PIM20.41656903
128PIK3CA0.41356591
129WNK40.40881396
130CSF1R0.40801114
131BRD40.40319710
132DYRK1B0.40231091
133NTRK20.39631617
134TLK10.38888169
135PRKG10.37978104
136PHKG10.35765522
137PHKG20.35765522
138BTK0.34922743
139CDK70.34750322
140LMTK20.34531033
141CDK180.34274385
142UHMK10.34264729
143ZAK0.34176511
144PRKACA0.34135576
145PLK30.34015930
146IRAK30.33632964
147CDK20.33373566
148LRRK20.33142136
149PINK10.33093373
150NTRK10.33063318
151CSNK1E0.32871204
152KDR0.32003359
153MAPK110.31044120
154DYRK1A0.30875018
155KIT0.30759492
156CDK50.30239506
157SIK20.29844592

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.70841832
2DNA replication_Homo sapiens_hsa030303.49283825
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.79158952
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69082788
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68755965
6Nicotine addiction_Homo sapiens_hsa050332.55394455
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.52979054
8Mismatch repair_Homo sapiens_hsa034302.50314312
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49770288
10Ribosome_Homo sapiens_hsa030102.49761067
11Selenocompound metabolism_Homo sapiens_hsa004502.48306053
12Folate biosynthesis_Homo sapiens_hsa007902.38250335
13One carbon pool by folate_Homo sapiens_hsa006702.30838427
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.28541863
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25833582
16RNA transport_Homo sapiens_hsa030132.16758665
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16351814
18Pyruvate metabolism_Homo sapiens_hsa006202.12559778
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09912242
20Carbon metabolism_Homo sapiens_hsa012001.91886795
21Biosynthesis of amino acids_Homo sapiens_hsa012301.91575882
22Pyrimidine metabolism_Homo sapiens_hsa002401.91301858
23Nucleotide excision repair_Homo sapiens_hsa034201.90865458
24Propanoate metabolism_Homo sapiens_hsa006401.81045929
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70261142
26RNA polymerase_Homo sapiens_hsa030201.66792280
27RNA degradation_Homo sapiens_hsa030181.64255245
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.63432191
29Regulation of autophagy_Homo sapiens_hsa041401.61111224
30Base excision repair_Homo sapiens_hsa034101.57539449
31Non-homologous end-joining_Homo sapiens_hsa034501.48554805
32Homologous recombination_Homo sapiens_hsa034401.47994758
33Spliceosome_Homo sapiens_hsa030401.47748468
34Fatty acid degradation_Homo sapiens_hsa000711.45202545
35Steroid biosynthesis_Homo sapiens_hsa001001.41720339
36Proteasome_Homo sapiens_hsa030501.37379312
37Protein export_Homo sapiens_hsa030601.34784125
38Pentose phosphate pathway_Homo sapiens_hsa000301.32969452
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32113515
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31844455
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31416668
42Parkinsons disease_Homo sapiens_hsa050121.29090965
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28026340
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27982729
45Sulfur relay system_Homo sapiens_hsa041221.27514781
46Cell cycle_Homo sapiens_hsa041101.26586431
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19735436
48Oocyte meiosis_Homo sapiens_hsa041141.12182410
49Huntingtons disease_Homo sapiens_hsa050161.07351066
50Nitrogen metabolism_Homo sapiens_hsa009101.05822710
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.04815326
52Glucagon signaling pathway_Homo sapiens_hsa049221.04593492
53Taste transduction_Homo sapiens_hsa047421.04307422
54Arginine biosynthesis_Homo sapiens_hsa002201.03473659
55Oxidative phosphorylation_Homo sapiens_hsa001901.01908736
56Thyroid cancer_Homo sapiens_hsa052161.01591358
57Purine metabolism_Homo sapiens_hsa002300.99419103
58GABAergic synapse_Homo sapiens_hsa047270.98599868
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.95931092
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92590646
61Fatty acid elongation_Homo sapiens_hsa000620.87886294
62Phototransduction_Homo sapiens_hsa047440.87727058
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87636763
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85915707
65Insulin secretion_Homo sapiens_hsa049110.82068453
66Systemic lupus erythematosus_Homo sapiens_hsa053220.80616096
67Tryptophan metabolism_Homo sapiens_hsa003800.78370191
68Starch and sucrose metabolism_Homo sapiens_hsa005000.78162856
69Galactose metabolism_Homo sapiens_hsa000520.76033937
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75053963
71N-Glycan biosynthesis_Homo sapiens_hsa005100.72644186
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.72482207
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72429722
74Cardiac muscle contraction_Homo sapiens_hsa042600.68761866
75Alzheimers disease_Homo sapiens_hsa050100.68689108
76Long-term potentiation_Homo sapiens_hsa047200.67073275
77Butanoate metabolism_Homo sapiens_hsa006500.65869246
78Antigen processing and presentation_Homo sapiens_hsa046120.63598729
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61989569
80Phenylalanine metabolism_Homo sapiens_hsa003600.59794831
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59637948
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58004219
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57247858
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.57074427
85Basal transcription factors_Homo sapiens_hsa030220.57066168
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56904494
87mRNA surveillance pathway_Homo sapiens_hsa030150.56513437
88Alcoholism_Homo sapiens_hsa050340.55505642
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52956865
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52835163
91Insulin signaling pathway_Homo sapiens_hsa049100.49905686
92Metabolic pathways_Homo sapiens_hsa011000.49489787
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46920774
94Long-term depression_Homo sapiens_hsa047300.46699938
95Morphine addiction_Homo sapiens_hsa050320.45326715
96Amphetamine addiction_Homo sapiens_hsa050310.44665443
97Insulin resistance_Homo sapiens_hsa049310.43986193
98Fatty acid metabolism_Homo sapiens_hsa012120.42380724
99Fructose and mannose metabolism_Homo sapiens_hsa000510.42248286
100Circadian entrainment_Homo sapiens_hsa047130.42241208
101Cocaine addiction_Homo sapiens_hsa050300.41905955
102Glutamatergic synapse_Homo sapiens_hsa047240.41715787
103p53 signaling pathway_Homo sapiens_hsa041150.41198706
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38802889
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36293105
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36197495
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35223596
108AMPK signaling pathway_Homo sapiens_hsa041520.34790244
109Colorectal cancer_Homo sapiens_hsa052100.34462104
110Dopaminergic synapse_Homo sapiens_hsa047280.33865214
111Viral carcinogenesis_Homo sapiens_hsa052030.33705993
112beta-Alanine metabolism_Homo sapiens_hsa004100.33571683
113ABC transporters_Homo sapiens_hsa020100.33436749
114Lysine degradation_Homo sapiens_hsa003100.32156136
115Epstein-Barr virus infection_Homo sapiens_hsa051690.31392136
116mTOR signaling pathway_Homo sapiens_hsa041500.29715290
117Peroxisome_Homo sapiens_hsa041460.29398128
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.28618543
119Gap junction_Homo sapiens_hsa045400.27260626
120Fanconi anemia pathway_Homo sapiens_hsa034600.26607361
121Retinol metabolism_Homo sapiens_hsa008300.25957661
122Caffeine metabolism_Homo sapiens_hsa002320.25711122
123Olfactory transduction_Homo sapiens_hsa047400.25464802
124Type I diabetes mellitus_Homo sapiens_hsa049400.25391232
125Tyrosine metabolism_Homo sapiens_hsa003500.25148999
126Acute myeloid leukemia_Homo sapiens_hsa052210.25062929
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24910972
128Sulfur metabolism_Homo sapiens_hsa009200.24613054
129Fatty acid biosynthesis_Homo sapiens_hsa000610.23135475
130Axon guidance_Homo sapiens_hsa043600.22517080
131Prolactin signaling pathway_Homo sapiens_hsa049170.21528573
132Bile secretion_Homo sapiens_hsa049760.20108113
133Circadian rhythm_Homo sapiens_hsa047100.18753836

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