ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	interferon-gamma production (GO:0032609)	8.20313296
2	serotonin receptor signaling pathway (GO:0007210)	7.12934130
3	activated T cell proliferation (GO:0050798)	6.04360643
4	negative regulation of interleukin-8 production (GO:0032717)	6.02310060
5	regulation of appetite (GO:0032098)	5.70646479
6	positive regulation of hair cycle (GO:0042635)	5.36722255
7	positive regulation of hair follicle development (GO:0051798)	5.36722255
8	negative regulation of circadian rhythm (GO:0042754)	4.96971247
9	cilium or flagellum-dependent cell motility (GO:0001539)	4.91891860
10	protein K63-linked deubiquitination (GO:0070536)	4.68677640
11	DNA double-strand break processing (GO:0000729)	4.63793067
12	protein K48-linked deubiquitination (GO:0071108)	4.61571940
13	retinal cone cell development (GO:0046549)	4.47793920
14	hematopoietic stem cell proliferation (GO:0071425)	4.28946779
15	positive regulation of osteoblast proliferation (GO:0033690)	4.28786796
16	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.11253033
17	protein-cofactor linkage (GO:0018065)	4.05234569
18	angiogenesis involved in wound healing (GO:0060055)	4.04917664
19	regulation of Cdc42 GTPase activity (GO:0043088)	4.04783471
20	glycoprotein catabolic process (GO:0006516)	3.97029991
21	neural tube formation (GO:0001841)	3.93793888
22	cysteine metabolic process (GO:0006534)	3.93401612
23	thyroid hormone metabolic process (GO:0042403)	3.89203734
24	killing of cells of other organism (GO:0031640)	3.87852527
25	disruption of cells of other organism (GO:0044364)	3.87852527
26	positive regulation of T cell cytokine production (GO:0002726)	3.87254995
27	regulation of B cell receptor signaling pathway (GO:0050855)	3.81896495
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.81816304
29	protein K6-linked ubiquitination (GO:0085020)	3.77499512
30	righting reflex (GO:0060013)	3.74748851
31	sulfation (GO:0051923)	3.73905744
32	glycerophospholipid catabolic process (GO:0046475)	3.73854458
33	carnitine metabolic process (GO:0009437)	3.70107434
34	replication fork processing (GO:0031297)	3.66975318
35	granulocyte differentiation (GO:0030851)	3.61379811
36	omega-hydroxylase P450 pathway (GO:0097267)	3.46528320
37	positive regulation of T-helper 1 type immune response (GO:0002827)	3.45669694
38	carnitine transmembrane transport (GO:1902603)	3.40304724
39	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.38554113
40	negative regulation of T cell mediated immunity (GO:0002710)	3.32538850
41	intra-S DNA damage checkpoint (GO:0031573)	3.30671528
42	mucosal immune response (GO:0002385)	3.28441100
43	homocysteine metabolic process (GO:0050667)	3.26055873
44	epithelial cilium movement (GO:0003351)	3.25462405
45	lymphangiogenesis (GO:0001946)	3.24904921
46	protein sumoylation (GO:0016925)	3.24172989
47	synapsis (GO:0007129)	3.23483928
48	tyrosine phosphorylation of STAT protein (GO:0007260)	3.22750985
49	establishment of protein localization to Golgi (GO:0072600)	3.20826822
50	lipid translocation (GO:0034204)	3.19277746
51	phospholipid translocation (GO:0045332)	3.19277746
52	startle response (GO:0001964)	3.11323121
53	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.09783471
54	regulation of hair follicle development (GO:0051797)	3.07277396
55	tryptophan catabolic process (GO:0006569)	3.06479940
56	indole-containing compound catabolic process (GO:0042436)	3.06479940
57	indolalkylamine catabolic process (GO:0046218)	3.06479940
58	amino-acid betaine transport (GO:0015838)	3.04616005
59	carnitine transport (GO:0015879)	3.04616005
60	rRNA catabolic process (GO:0016075)	3.03667382
61	reflex (GO:0060004)	3.03623746
62	DNA integration (GO:0015074)	3.02287300
63	positive regulation of granulocyte differentiation (GO:0030854)	3.01330399
64	organ or tissue specific immune response (GO:0002251)	2.97742047
65	cilium movement (GO:0003341)	2.96157455
66	axoneme assembly (GO:0035082)	2.94928874
67	histone mRNA catabolic process (GO:0071044)	2.91257111
68	amino-acid betaine metabolic process (GO:0006577)	2.89537333
69	regulation of T cell chemotaxis (GO:0010819)	2.83430412
70	positive regulation of T cell chemotaxis (GO:0010820)	2.83430412
71	dosage compensation (GO:0007549)	2.81458107
72	DNA strand renaturation (GO:0000733)	2.79121071
73	negative regulation of metanephros development (GO:0072217)	2.78496220
74	regulation of hair cycle (GO:0042634)	2.77747472
75	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.77696282
76	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.77496460
77	negative regulation by host of viral transcription (GO:0043922)	2.77313278
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76966488
79	negative regulation of mast cell activation (GO:0033004)	2.74347707
80	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.74169998
81	detection of light stimulus involved in sensory perception (GO:0050962)	2.72906023
82	detection of light stimulus involved in visual perception (GO:0050908)	2.72906023
83	cilium morphogenesis (GO:0060271)	2.72054544
84	regulation of sarcomere organization (GO:0060297)	2.70336009
85	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.68176160
86	organic cation transport (GO:0015695)	2.67582609
87	DNA catabolic process, exonucleolytic (GO:0000738)	2.67396790
88	positive regulation of cAMP-mediated signaling (GO:0043950)	2.66791643
89	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.66500475
90	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.66297891
91	tryptophan metabolic process (GO:0006568)	2.65985167
92	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.65707137
93	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.65707137
94	photoreceptor cell maintenance (GO:0045494)	2.63183127
95	pseudouridine synthesis (GO:0001522)	2.61010806
96	piRNA metabolic process (GO:0034587)	2.59788807
97	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.58831771
98	cell killing (GO:0001906)	2.58613980
99	androgen biosynthetic process (GO:0006702)	2.57767433
100	protein K11-linked deubiquitination (GO:0035871)	11.4172472

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.77814617
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.20233179
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92670593
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.84664823
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.69716798
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.65121228
7	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.64172692
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.54737083
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.42647510
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37440569
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.22146411
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.20911153
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.20015231
14	FUS_26573619_Chip-Seq_HEK293_Human	2.18947148
15	EWS_26573619_Chip-Seq_HEK293_Human	2.08803315
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.08742739
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99039011
18	VDR_22108803_ChIP-Seq_LS180_Human	1.98602293
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94852454
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.89477056
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.88447814
22	P300_19829295_ChIP-Seq_ESCs_Human	1.87708173
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.86412365
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.82332475
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.80857845
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79195549
27	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.78875562
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75933312
29	E2F7_22180533_ChIP-Seq_HELA_Human	1.71670941
30	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.71670610
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71206267
32	AR_25329375_ChIP-Seq_VCAP_Human	1.69801367
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.66236876
34	TP53_16413492_ChIP-PET_HCT116_Human	1.66151475
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.64168311
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.63437492
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61837807
38	STAT3_23295773_ChIP-Seq_U87_Human	1.61425639
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61030342
40	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.60390113
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60377292
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57701943
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56659517
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.55425441
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52654962
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.45793092
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45793092
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44219139
49	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.43980135
50	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.43485770
51	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.42575898
52	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.40695767
53	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40688102
54	TCF4_23295773_ChIP-Seq_U87_Human	1.40125607
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.38250117
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36394630
57	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.36319155
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33377337
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31322908
60	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.30451743
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30254345
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29966498
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28196459
64	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27908267
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26102100
66	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.24668238
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.24523022
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23822416
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23385848
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22925398
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22908675
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.19426735
73	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19227240
74	FOXP3_21729870_ChIP-Seq_TREG_Human	1.18809304
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18703282
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.12615222
77	DCP1A_22483619_ChIP-Seq_HELA_Human	1.09427567
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08921741
79	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.08920198
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08898674
81	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.05769505
82	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05388861
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03482561
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01144156
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00260634
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00205621
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97902723
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97801525
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97627791
90	CDX2_22108803_ChIP-Seq_LS180_Human	0.97541094
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97140631
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96857500
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96322223
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95320620
95	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.94347974
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.94056912
97	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.93627569
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93531551
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.92520806
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.91385112

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	4.42632949
2	MP0005310_abnormal_salivary_gland	4.13403610
3	MP0001984_abnormal_olfaction	3.82897262
4	MP0000569_abnormal_digit_pigmentation	3.18390530
5	MP0008875_abnormal_xenobiotic_pharmacok	3.15930600
6	MP0002138_abnormal_hepatobiliary_system	2.67487786
7	MP0006276_abnormal_autonomic_nervous	2.59416664
8	MP0005551_abnormal_eye_electrophysiolog	2.44855347
9	MP0003806_abnormal_nucleotide_metabolis	2.44088974
10	MP0000383_abnormal_hair_follicle	2.39357827
11	MP0000372_irregular_coat_pigmentation	2.29863683
12	MP0005253_abnormal_eye_physiology	2.15254836
13	MP0002006_tumorigenesis	2.12869803
14	MP0004043_abnormal_pH_regulation	2.04140081
15	MP0009046_muscle_twitch	2.02970151
16	MP0010094_abnormal_chromosome_stability	2.02605498
17	MP0004142_abnormal_muscle_tone	1.87527252
18	MP0008877_abnormal_DNA_methylation	1.84890848
19	MP0005084_abnormal_gallbladder_morpholo	1.74085634
20	MP0001919_abnormal_reproductive_system	1.73800456
21	MP0002928_abnormal_bile_duct	1.71834402
22	MP0005389_reproductive_system_phenotype	1.65400132
23	MP0010678_abnormal_skin_adnexa	1.57682392
24	MP0002139_abnormal_hepatobiliary_system	1.53440031
25	MP0005187_abnormal_penis_morphology	1.50619426
26	MP0000613_abnormal_salivary_gland	1.47459394
27	MP0010386_abnormal_urinary_bladder	1.45038026
28	MP0002736_abnormal_nociception_after	1.44864700
29	MP0005670_abnormal_white_adipose	1.44849345
30	MP0001986_abnormal_taste_sensitivity	1.42727953
31	MP0008058_abnormal_DNA_repair	1.39291583
32	MP0000427_abnormal_hair_cycle	1.38562210
33	MP0001501_abnormal_sleep_pattern	1.38545765
34	MP0002638_abnormal_pupillary_reflex	1.34909328
35	MP0001486_abnormal_startle_reflex	1.32402947
36	MP0001764_abnormal_homeostasis	1.32115279
37	MP0001968_abnormal_touch/_nociception	1.30352790
38	MP0006072_abnormal_retinal_apoptosis	1.30207047
39	MP0005174_abnormal_tail_pigmentation	1.27810028
40	MP0000015_abnormal_ear_pigmentation	1.26815205
41	MP0002970_abnormal_white_adipose	1.25093876
42	MP0009745_abnormal_behavioral_response	1.22871550
43	MP0006035_abnormal_mitochondrial_morpho	1.22455230
44	MP0005171_absent_coat_pigmentation	1.19692551
45	MP0008057_abnormal_DNA_replication	1.17178831
46	MP0002653_abnormal_ependyma_morphology	1.17088174
47	MP0003724_increased_susceptibility_to	1.14879138
48	MP0003195_calcinosis	1.13695794
49	MP0002254_reproductive_system_inflammat	1.13283327
50	MP0002396_abnormal_hematopoietic_system	1.09671916
51	MP0002735_abnormal_chemical_nociception	1.09048410
52	MP0002064_seizures	1.04476113
53	MP0003763_abnormal_thymus_physiology	1.01356634
54	MP0005647_abnormal_sex_gland	0.97575539
55	MP0003136_yellow_coat_color	0.96215059
56	MP0000230_abnormal_systemic_arterial	0.95358301
57	MP0002210_abnormal_sex_determination	0.94540653
58	MP0003880_abnormal_central_pattern	0.94338715
59	MP0000013_abnormal_adipose_tissue	0.94055913
60	MP0002067_abnormal_sensory_capabilities	0.93437411
61	MP0002572_abnormal_emotion/affect_behav	0.91793800
62	MP0002095_abnormal_skin_pigmentation	0.90816587
63	MP0002160_abnormal_reproductive_system	0.90546286
64	MP0003786_premature_aging	0.88517960
65	MP0000653_abnormal_sex_gland	0.87433646
66	MP0005645_abnormal_hypothalamus_physiol	0.87199453
67	MP0001485_abnormal_pinna_reflex	0.86932615
68	MP0003252_abnormal_bile_duct	0.85784784
69	MP0003698_abnormal_male_reproductive	0.84004809
70	MP0006082_CNS_inflammation	0.83788244
71	MP0002822_catalepsy	0.83730409
72	MP0000639_abnormal_adrenal_gland	0.83201866
73	MP0000647_abnormal_sebaceous_gland	0.81966229
74	MP0001529_abnormal_vocalization	0.81272737
75	MP0005452_abnormal_adipose_tissue	0.79707087
76	MP0001324_abnormal_eye_pigmentation	0.77938654
77	MP0002272_abnormal_nervous_system	0.77106529
78	MP0002269_muscular_atrophy	0.76308148
79	MP0001346_abnormal_lacrimal_gland	0.76044102
80	MP0001145_abnormal_male_reproductive	0.74296246
81	MP0002102_abnormal_ear_morphology	0.74215424
82	MP0005195_abnormal_posterior_eye	0.74043370
83	MP0000685_abnormal_immune_system	0.73766269
84	MP0001905_abnormal_dopamine_level	0.73403651
85	MP0002229_neurodegeneration	0.73401832
86	MP0001970_abnormal_pain_threshold	0.72718894
87	MP0003787_abnormal_imprinting	0.72542751
88	MP0001929_abnormal_gametogenesis	0.72346416
89	MP0000358_abnormal_cell_content/	0.71633798
90	MP0004957_abnormal_blastocyst_morpholog	0.70433273
91	MP0003011_delayed_dark_adaptation	0.70416779
92	MP0005386_behavior/neurological_phenoty	0.68738449
93	MP0004924_abnormal_behavior	0.68738449
94	MP0008872_abnormal_physiological_respon	0.66572945
95	MP0005410_abnormal_fertilization	0.66317391
96	MP0003718_maternal_effect	0.66206723
97	MP0002971_abnormal_brown_adipose	0.65493566
98	MP0000371_diluted_coat_color	0.65359475
99	MP0002063_abnormal_learning/memory/cond	0.65311150
100	MP0005332_abnormal_amino_acid	0.63106891

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retrobulbar optic neuritis (HP:0100654)	6.10886177
2	Optic neuritis (HP:0100653)	6.10886177
3	Orchitis (HP:0100796)	5.22945745
4	Keratoconjunctivitis (HP:0001096)	4.53131250
5	Myositis (HP:0100614)	4.13407552
6	True hermaphroditism (HP:0010459)	4.13245308
7	Keratoconjunctivitis sicca (HP:0001097)	3.98988165
8	Chronic hepatic failure (HP:0100626)	3.98939624
9	Poikiloderma (HP:0001029)	3.83029508
10	Congenital sensorineural hearing impairment (HP:0008527)	3.57140554
11	Pancreatic cysts (HP:0001737)	3.45528424
12	Pancreatic fibrosis (HP:0100732)	3.43919002
13	Abolished electroretinogram (ERG) (HP:0000550)	3.25672776
14	Abnormality of midbrain morphology (HP:0002418)	3.11932519
15	Molar tooth sign on MRI (HP:0002419)	3.11932519
16	Attenuation of retinal blood vessels (HP:0007843)	3.08740201
17	Congenital stationary night blindness (HP:0007642)	3.07509464
18	Bilateral sensorineural hearing impairment (HP:0008619)	3.07301668
19	Encephalitis (HP:0002383)	2.94780454
20	Bony spicule pigmentary retinopathy (HP:0007737)	2.88670396
21	Abnormality of the labia minora (HP:0012880)	2.87854410
22	Keratitis (HP:0000491)	2.84409504
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.76032282
24	Bile duct proliferation (HP:0001408)	2.71775800
25	Abnormal biliary tract physiology (HP:0012439)	2.71775800
26	Lower limb hyperreflexia (HP:0002395)	2.69497844
27	Dyschromatopsia (HP:0007641)	2.56789839
28	Retinal dysplasia (HP:0007973)	2.55183782
29	Male pseudohermaphroditism (HP:0000037)	2.47895336
30	Absent/shortened dynein arms (HP:0200106)	2.43251356
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.43251356
32	Anorexia (HP:0002039)	2.41009466
33	Abnormal ciliary motility (HP:0012262)	2.40653607
34	Recurrent cutaneous fungal infections (HP:0011370)	2.30554898
35	Chronic mucocutaneous candidiasis (HP:0002728)	2.30554898
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.27023620
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.27023620
38	Decreased circulating renin level (HP:0003351)	2.25581032
39	Absent speech (HP:0001344)	2.25122971
40	Hypoplasia of the uterus (HP:0000013)	2.24666497
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23484390
42	Horizontal nystagmus (HP:0000666)	2.21330697
43	Stomatitis (HP:0010280)	2.20956391
44	Hyperventilation (HP:0002883)	2.20573626
45	Hyperglycinuria (HP:0003108)	2.20090828
46	Abnormality of the pericardium (HP:0001697)	2.19760116
47	Abnormality of the renal cortex (HP:0011035)	2.18655644
48	Aplasia/hypoplasia of the uterus (HP:0008684)	2.16438669
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.14638905
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.10808564
51	Abnormal pancreas size (HP:0012094)	2.07442728
52	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.06904800
53	Gaze-evoked nystagmus (HP:0000640)	2.03336373
54	Arterial thrombosis (HP:0004420)	2.02818277
55	Abnormal drinking behavior (HP:0030082)	2.02166723
56	Polydipsia (HP:0001959)	2.02166723
57	Nephronophthisis (HP:0000090)	2.01119881
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00606901
59	Type II lissencephaly (HP:0007260)	1.99951020
60	Gangrene (HP:0100758)	1.98207210
61	Constricted visual fields (HP:0001133)	1.97248908
62	Hemoptysis (HP:0002105)	1.96163884
63	Medial flaring of the eyebrow (HP:0010747)	1.95382901
64	Hypoplastic ischia (HP:0003175)	1.93983366
65	Gonadotropin excess (HP:0000837)	1.93885035
66	Gout (HP:0001997)	1.93720925
67	Abnormality of dental color (HP:0011073)	1.93191381
68	Tubulointerstitial nephritis (HP:0001970)	1.89710667
69	Tubular atrophy (HP:0000092)	1.89611448
70	Hyperglycinemia (HP:0002154)	1.88355799
71	Sloping forehead (HP:0000340)	1.88115944
72	Tachypnea (HP:0002789)	1.85841643
73	Recurrent sinusitis (HP:0011108)	1.85158852
74	Renal cortical cysts (HP:0000803)	1.81657267
75	Abnormality of chromosome stability (HP:0003220)	1.78106957
76	Cystic liver disease (HP:0006706)	1.77854069
77	Abnormality of the ileum (HP:0001549)	1.77005788
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.75266976
79	Abnormality of the renal medulla (HP:0100957)	1.74885444
80	Pancreatitis (HP:0001733)	1.74714286
81	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.72561366
82	Congenital hepatic fibrosis (HP:0002612)	1.71648435
83	Meckel diverticulum (HP:0002245)	1.71534515
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.70432867
85	Large for gestational age (HP:0001520)	1.70356154
86	Hepatocellular necrosis (HP:0001404)	1.68073018
87	Patellar aplasia (HP:0006443)	1.67199408
88	Photophobia (HP:0000613)	1.65382362
89	Retinitis pigmentosa (HP:0000510)	1.65201213
90	Fair hair (HP:0002286)	1.64885187
91	Abnormality of glycine metabolism (HP:0010895)	1.64623976
92	Abnormality of serine family amino acid metabolism (HP:0010894)	1.64623976
93	Congenital primary aphakia (HP:0007707)	1.64338301
94	Glomerulopathy (HP:0100820)	1.63694709
95	Tinnitus (HP:0000360)	1.63541662
96	Stomach cancer (HP:0012126)	1.62872467
97	Oligodactyly (hands) (HP:0001180)	1.62491572
98	Pulmonary embolism (HP:0002204)	1.62004626
99	Hepatic necrosis (HP:0002605)	1.60229492
100	Type II diabetes mellitus (HP:0005978)	1.59863176

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.30327949
2	WNK3	5.54741535
3	TXK	3.46551377
4	ZAK	2.76187454
5	PINK1	2.68370900
6	BLK	2.27125089
7	TAOK3	2.08029823
8	BMPR1B	2.03149012
9	IRAK1	1.92188065
10	BCKDK	1.89136450
11	EIF2AK3	1.84188236
12	YES1	1.84101723
13	TLK1	1.78290814
14	NEK9	1.61203353
15	FER	1.58805312
16	TRIM28	1.58558971
17	MAP3K4	1.52235454
18	BUB1	1.47792047
19	MAP4K2	1.36931735
20	MAPK13	1.36678775
21	PLK4	1.34884883
22	NUAK1	1.33879953
23	MAP2K7	1.20149663
24	CCNB1	1.17573303
25	ERBB3	1.16235152
26	SRPK1	1.09912966
27	MAPKAPK3	1.09814498
28	OXSR1	1.06568389
29	EPHA3	1.06281434
30	CASK	1.04772430
31	PIK3CA	1.02278117
32	ACVR1B	1.01290943
33	EIF2AK2	0.99489699
34	STK38L	0.94009883
35	TESK2	0.92128237
36	STK39	0.91536555
37	MKNK1	0.89810679
38	ADRBK2	0.86332789
39	MARK1	0.84094204
40	GRK1	0.83512281
41	VRK1	0.82917560
42	RPS6KA5	0.82779099
43	WNK4	0.82498798
44	PLK2	0.81071037
45	DYRK2	0.77053380
46	TTK	0.76845980
47	GRK5	0.74977050
48	ATR	0.74776173
49	EPHA4	0.72631272
50	BRSK2	0.71550230
51	TGFBR1	0.70140215
52	NEK6	0.65817519
53	PLK1	0.65181222
54	BCR	0.64843413
55	CHEK2	0.62127468
56	TEC	0.61478471
57	MATK	0.61018110
58	FLT3	0.60828504
59	MUSK	0.59956600
60	DAPK1	0.59065011
61	NEK1	0.58561048
62	PRKCZ	0.58066990
63	CSNK1G2	0.57424709
64	MST4	0.56958717
65	TNK2	0.56323046
66	IKBKB	0.54689911
67	KDR	0.53424899
68	CSK	0.52333218
69	MARK3	0.51988641
70	ERBB2	0.50353412
71	CSNK1A1L	0.50228152
72	MAPKAPK5	0.48424122
73	PAK3	0.47851535
74	ADRBK1	0.47614918
75	MKNK2	0.46830563
76	CSF1R	0.45328773
77	RAF1	0.43253377
78	NTRK3	0.43011222
79	PLK3	0.41136005
80	EPHB1	0.40811595
81	PKN1	0.40683267
82	PKN2	0.38467162
83	MAP2K4	0.38187729
84	PRKG1	0.37787404
85	CSNK1G3	0.37215691
86	LYN	0.36333471
87	ATM	0.34193595
88	GRK7	0.33322725
89	BTK	0.32766728
90	SYK	0.31989276
91	EIF2AK1	0.31734850
92	CDK6	0.31690405
93	PRKCQ	0.31290619
94	ITK	0.31199962
95	IGF1R	0.31166621
96	PRKCB	0.28671741
97	CSNK1G1	0.27415041
98	WEE1	0.26757121
99	JAK1	0.26602280
100	STK16	0.26353487

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.29438514
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.15129304
3	Proteasome_Homo sapiens_hsa03050	2.81858368
4	Propanoate metabolism_Homo sapiens_hsa00640	2.80574953
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.68401351
6	Butanoate metabolism_Homo sapiens_hsa00650	2.58566293
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.51887309
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.46880933
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.36305192
10	Homologous recombination_Homo sapiens_hsa03440	2.28781630
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.28168835
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.23551189
13	Base excision repair_Homo sapiens_hsa03410	2.20448272
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.03176102
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.98620825
16	Nicotine addiction_Homo sapiens_hsa05033	1.97198117
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.90271256
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79882081
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77919820
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.72476496
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.68520812
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.60181946
23	DNA replication_Homo sapiens_hsa03030	1.49974485
24	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.49581036
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.47202347
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.46474597
27	Peroxisome_Homo sapiens_hsa04146	1.44009487
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39392799
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34799680
30	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.33790382
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.32774184
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.32571243
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.28033632
34	Fatty acid degradation_Homo sapiens_hsa00071	1.27072812
35	Phototransduction_Homo sapiens_hsa04744	1.17476471
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16670052
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.11935400
38	Mismatch repair_Homo sapiens_hsa03430	1.11599272
39	RNA polymerase_Homo sapiens_hsa03020	1.08639131
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08548775
41	One carbon pool by folate_Homo sapiens_hsa00670	1.08369167
42	Basal transcription factors_Homo sapiens_hsa03022	1.03926291
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.02901254
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00218770
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.98465195
46	Salivary secretion_Homo sapiens_hsa04970	0.98190435
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96852175
48	RNA degradation_Homo sapiens_hsa03018	0.93748120
49	Serotonergic synapse_Homo sapiens_hsa04726	0.93592211
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93117255
51	RNA transport_Homo sapiens_hsa03013	0.87745326
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.86847794
53	Taste transduction_Homo sapiens_hsa04742	0.86789658
54	Parkinsons disease_Homo sapiens_hsa05012	0.86208852
55	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.86106703
56	Glutathione metabolism_Homo sapiens_hsa00480	0.85978924
57	Olfactory transduction_Homo sapiens_hsa04740	0.84490154
58	ABC transporters_Homo sapiens_hsa02010	0.83879142
59	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82402029
60	p53 signaling pathway_Homo sapiens_hsa04115	0.82360226
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.80616444
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.79068474
63	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.78390416
64	Histidine metabolism_Homo sapiens_hsa00340	0.75201892
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.73579734
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72227256
67	Huntingtons disease_Homo sapiens_hsa05016	0.69023905
68	Metabolic pathways_Homo sapiens_hsa01100	0.67209742
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.66295540
70	Lysine degradation_Homo sapiens_hsa00310	0.65346542
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62311893
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61668626
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61463231
74	Morphine addiction_Homo sapiens_hsa05032	0.60966007
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58952312
76	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.58194257
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.55931654
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55534784
79	Purine metabolism_Homo sapiens_hsa00230	0.53374180
80	Protein export_Homo sapiens_hsa03060	0.53071405
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46305144
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43467721
83	Long-term depression_Homo sapiens_hsa04730	0.42793967
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.42623980
85	Regulation of autophagy_Homo sapiens_hsa04140	0.38361842
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36420469
87	GABAergic synapse_Homo sapiens_hsa04727	0.34781958
88	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.34197213
89	Antigen processing and presentation_Homo sapiens_hsa04612	0.29079798
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29079140
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.27668107
92	Fatty acid elongation_Homo sapiens_hsa00062	0.27488437
93	Alcoholism_Homo sapiens_hsa05034	0.27017309
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.25071984
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.23028984
96	Alzheimers disease_Homo sapiens_hsa05010	0.21582109
97	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.20473457
98	Circadian rhythm_Homo sapiens_hsa04710	0.19458644
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.19021776
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.18222497

FAM185BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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