FAM185BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)8.20313296
2serotonin receptor signaling pathway (GO:0007210)7.12934130
3activated T cell proliferation (GO:0050798)6.04360643
4negative regulation of interleukin-8 production (GO:0032717)6.02310060
5regulation of appetite (GO:0032098)5.70646479
6positive regulation of hair cycle (GO:0042635)5.36722255
7positive regulation of hair follicle development (GO:0051798)5.36722255
8negative regulation of circadian rhythm (GO:0042754)4.96971247
9cilium or flagellum-dependent cell motility (GO:0001539)4.91891860
10protein K63-linked deubiquitination (GO:0070536)4.68677640
11DNA double-strand break processing (GO:0000729)4.63793067
12protein K48-linked deubiquitination (GO:0071108)4.61571940
13retinal cone cell development (GO:0046549)4.47793920
14hematopoietic stem cell proliferation (GO:0071425)4.28946779
15positive regulation of osteoblast proliferation (GO:0033690)4.28786796
16negative regulation of calcium ion transport into cytosol (GO:0010523)4.11253033
17protein-cofactor linkage (GO:0018065)4.05234569
18angiogenesis involved in wound healing (GO:0060055)4.04917664
19regulation of Cdc42 GTPase activity (GO:0043088)4.04783471
20glycoprotein catabolic process (GO:0006516)3.97029991
21neural tube formation (GO:0001841)3.93793888
22cysteine metabolic process (GO:0006534)3.93401612
23thyroid hormone metabolic process (GO:0042403)3.89203734
24killing of cells of other organism (GO:0031640)3.87852527
25disruption of cells of other organism (GO:0044364)3.87852527
26positive regulation of T cell cytokine production (GO:0002726)3.87254995
27regulation of B cell receptor signaling pathway (GO:0050855)3.81896495
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.81816304
29protein K6-linked ubiquitination (GO:0085020)3.77499512
30righting reflex (GO:0060013)3.74748851
31sulfation (GO:0051923)3.73905744
32glycerophospholipid catabolic process (GO:0046475)3.73854458
33carnitine metabolic process (GO:0009437)3.70107434
34replication fork processing (GO:0031297)3.66975318
35granulocyte differentiation (GO:0030851)3.61379811
36omega-hydroxylase P450 pathway (GO:0097267)3.46528320
37positive regulation of T-helper 1 type immune response (GO:0002827)3.45669694
38carnitine transmembrane transport (GO:1902603)3.40304724
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38554113
40negative regulation of T cell mediated immunity (GO:0002710)3.32538850
41intra-S DNA damage checkpoint (GO:0031573)3.30671528
42mucosal immune response (GO:0002385)3.28441100
43homocysteine metabolic process (GO:0050667)3.26055873
44epithelial cilium movement (GO:0003351)3.25462405
45lymphangiogenesis (GO:0001946)3.24904921
46protein sumoylation (GO:0016925)3.24172989
47synapsis (GO:0007129)3.23483928
48tyrosine phosphorylation of STAT protein (GO:0007260)3.22750985
49establishment of protein localization to Golgi (GO:0072600)3.20826822
50lipid translocation (GO:0034204)3.19277746
51phospholipid translocation (GO:0045332)3.19277746
52startle response (GO:0001964)3.11323121
53negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.09783471
54regulation of hair follicle development (GO:0051797)3.07277396
55tryptophan catabolic process (GO:0006569)3.06479940
56indole-containing compound catabolic process (GO:0042436)3.06479940
57indolalkylamine catabolic process (GO:0046218)3.06479940
58amino-acid betaine transport (GO:0015838)3.04616005
59carnitine transport (GO:0015879)3.04616005
60rRNA catabolic process (GO:0016075)3.03667382
61reflex (GO:0060004)3.03623746
62DNA integration (GO:0015074)3.02287300
63positive regulation of granulocyte differentiation (GO:0030854)3.01330399
64organ or tissue specific immune response (GO:0002251)2.97742047
65cilium movement (GO:0003341)2.96157455
66axoneme assembly (GO:0035082)2.94928874
67histone mRNA catabolic process (GO:0071044)2.91257111
68amino-acid betaine metabolic process (GO:0006577)2.89537333
69regulation of T cell chemotaxis (GO:0010819)2.83430412
70positive regulation of T cell chemotaxis (GO:0010820)2.83430412
71dosage compensation (GO:0007549)2.81458107
72DNA strand renaturation (GO:0000733)2.79121071
73negative regulation of metanephros development (GO:0072217)2.78496220
74regulation of hair cycle (GO:0042634)2.77747472
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77696282
76positive regulation of oligodendrocyte differentiation (GO:0048714)2.77496460
77negative regulation by host of viral transcription (GO:0043922)2.77313278
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76966488
79negative regulation of mast cell activation (GO:0033004)2.74347707
80negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.74169998
81detection of light stimulus involved in sensory perception (GO:0050962)2.72906023
82detection of light stimulus involved in visual perception (GO:0050908)2.72906023
83cilium morphogenesis (GO:0060271)2.72054544
84regulation of sarcomere organization (GO:0060297)2.70336009
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68176160
86organic cation transport (GO:0015695)2.67582609
87DNA catabolic process, exonucleolytic (GO:0000738)2.67396790
88positive regulation of cAMP-mediated signaling (GO:0043950)2.66791643
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66500475
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66297891
91tryptophan metabolic process (GO:0006568)2.65985167
923-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.65707137
93purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.65707137
94photoreceptor cell maintenance (GO:0045494)2.63183127
95pseudouridine synthesis (GO:0001522)2.61010806
96piRNA metabolic process (GO:0034587)2.59788807
97regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58831771
98cell killing (GO:0001906)2.58613980
99androgen biosynthetic process (GO:0006702)2.57767433
100protein K11-linked deubiquitination (GO:0035871)11.4172472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.77814617
2TAF15_26573619_Chip-Seq_HEK293_Human3.20233179
3ZNF274_21170338_ChIP-Seq_K562_Hela2.92670593
4IGF1R_20145208_ChIP-Seq_DFB_Human2.84664823
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69716798
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65121228
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.64172692
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54737083
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.42647510
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37440569
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22146411
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.20911153
13AR_21572438_ChIP-Seq_LNCaP_Human2.20015231
14FUS_26573619_Chip-Seq_HEK293_Human2.18947148
15EWS_26573619_Chip-Seq_HEK293_Human2.08803315
16ER_23166858_ChIP-Seq_MCF-7_Human2.08742739
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99039011
18VDR_22108803_ChIP-Seq_LS180_Human1.98602293
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94852454
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89477056
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88447814
22P300_19829295_ChIP-Seq_ESCs_Human1.87708173
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86412365
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82332475
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80857845
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79195549
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.78875562
28SMAD4_21799915_ChIP-Seq_A2780_Human1.75933312
29E2F7_22180533_ChIP-Seq_HELA_Human1.71670941
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71670610
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71206267
32AR_25329375_ChIP-Seq_VCAP_Human1.69801367
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66236876
34TP53_16413492_ChIP-PET_HCT116_Human1.66151475
35TP53_22573176_ChIP-Seq_HFKS_Human1.64168311
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63437492
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61837807
38STAT3_23295773_ChIP-Seq_U87_Human1.61425639
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61030342
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.60390113
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60377292
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57701943
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56659517
44VDR_23849224_ChIP-Seq_CD4+_Human1.55425441
45IRF1_19129219_ChIP-ChIP_H3396_Human1.52654962
46CBP_20019798_ChIP-Seq_JUKART_Human1.45793092
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45793092
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44219139
49OCT4_21477851_ChIP-Seq_ESCs_Mouse1.43980135
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.43485770
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.42575898
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.40695767
53LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40688102
54TCF4_23295773_ChIP-Seq_U87_Human1.40125607
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38250117
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.36394630
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36319155
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.33377337
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31322908
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30451743
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30254345
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29966498
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28196459
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.27908267
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26102100
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24668238
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.24523022
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23822416
69RUNX2_22187159_ChIP-Seq_PCA_Human1.23385848
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22925398
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22908675
72MYC_18940864_ChIP-ChIP_HL60_Human1.19426735
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19227240
74FOXP3_21729870_ChIP-Seq_TREG_Human1.18809304
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18703282
76TCF4_22108803_ChIP-Seq_LS180_Human1.12615222
77DCP1A_22483619_ChIP-Seq_HELA_Human1.09427567
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08921741
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.08920198
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.08898674
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05769505
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.05388861
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03482561
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.01144156
85P53_22387025_ChIP-Seq_ESCs_Mouse1.00260634
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.00205621
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97902723
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.97801525
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97627791
90CDX2_22108803_ChIP-Seq_LS180_Human0.97541094
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97140631
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.96857500
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96322223
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.95320620
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94347974
96ERG_20517297_ChIP-Seq_VCAP_Human0.94056912
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93627569
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93531551
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92520806
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.91385112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.42632949
2MP0005310_abnormal_salivary_gland4.13403610
3MP0001984_abnormal_olfaction3.82897262
4MP0000569_abnormal_digit_pigmentation3.18390530
5MP0008875_abnormal_xenobiotic_pharmacok3.15930600
6MP0002138_abnormal_hepatobiliary_system2.67487786
7MP0006276_abnormal_autonomic_nervous2.59416664
8MP0005551_abnormal_eye_electrophysiolog2.44855347
9MP0003806_abnormal_nucleotide_metabolis2.44088974
10MP0000383_abnormal_hair_follicle2.39357827
11MP0000372_irregular_coat_pigmentation2.29863683
12MP0005253_abnormal_eye_physiology2.15254836
13MP0002006_tumorigenesis2.12869803
14MP0004043_abnormal_pH_regulation2.04140081
15MP0009046_muscle_twitch2.02970151
16MP0010094_abnormal_chromosome_stability2.02605498
17MP0004142_abnormal_muscle_tone1.87527252
18MP0008877_abnormal_DNA_methylation1.84890848
19MP0005084_abnormal_gallbladder_morpholo1.74085634
20MP0001919_abnormal_reproductive_system1.73800456
21MP0002928_abnormal_bile_duct1.71834402
22MP0005389_reproductive_system_phenotype1.65400132
23MP0010678_abnormal_skin_adnexa1.57682392
24MP0002139_abnormal_hepatobiliary_system1.53440031
25MP0005187_abnormal_penis_morphology1.50619426
26MP0000613_abnormal_salivary_gland1.47459394
27MP0010386_abnormal_urinary_bladder1.45038026
28MP0002736_abnormal_nociception_after1.44864700
29MP0005670_abnormal_white_adipose1.44849345
30MP0001986_abnormal_taste_sensitivity1.42727953
31MP0008058_abnormal_DNA_repair1.39291583
32MP0000427_abnormal_hair_cycle1.38562210
33MP0001501_abnormal_sleep_pattern1.38545765
34MP0002638_abnormal_pupillary_reflex1.34909328
35MP0001486_abnormal_startle_reflex1.32402947
36MP0001764_abnormal_homeostasis1.32115279
37MP0001968_abnormal_touch/_nociception1.30352790
38MP0006072_abnormal_retinal_apoptosis1.30207047
39MP0005174_abnormal_tail_pigmentation1.27810028
40MP0000015_abnormal_ear_pigmentation1.26815205
41MP0002970_abnormal_white_adipose1.25093876
42MP0009745_abnormal_behavioral_response1.22871550
43MP0006035_abnormal_mitochondrial_morpho1.22455230
44MP0005171_absent_coat_pigmentation1.19692551
45MP0008057_abnormal_DNA_replication1.17178831
46MP0002653_abnormal_ependyma_morphology1.17088174
47MP0003724_increased_susceptibility_to1.14879138
48MP0003195_calcinosis1.13695794
49MP0002254_reproductive_system_inflammat1.13283327
50MP0002396_abnormal_hematopoietic_system1.09671916
51MP0002735_abnormal_chemical_nociception1.09048410
52MP0002064_seizures1.04476113
53MP0003763_abnormal_thymus_physiology1.01356634
54MP0005647_abnormal_sex_gland0.97575539
55MP0003136_yellow_coat_color0.96215059
56MP0000230_abnormal_systemic_arterial0.95358301
57MP0002210_abnormal_sex_determination0.94540653
58MP0003880_abnormal_central_pattern0.94338715
59MP0000013_abnormal_adipose_tissue0.94055913
60MP0002067_abnormal_sensory_capabilities0.93437411
61MP0002572_abnormal_emotion/affect_behav0.91793800
62MP0002095_abnormal_skin_pigmentation0.90816587
63MP0002160_abnormal_reproductive_system0.90546286
64MP0003786_premature_aging0.88517960
65MP0000653_abnormal_sex_gland0.87433646
66MP0005645_abnormal_hypothalamus_physiol0.87199453
67MP0001485_abnormal_pinna_reflex0.86932615
68MP0003252_abnormal_bile_duct0.85784784
69MP0003698_abnormal_male_reproductive0.84004809
70MP0006082_CNS_inflammation0.83788244
71MP0002822_catalepsy0.83730409
72MP0000639_abnormal_adrenal_gland0.83201866
73MP0000647_abnormal_sebaceous_gland0.81966229
74MP0001529_abnormal_vocalization0.81272737
75MP0005452_abnormal_adipose_tissue0.79707087
76MP0001324_abnormal_eye_pigmentation0.77938654
77MP0002272_abnormal_nervous_system0.77106529
78MP0002269_muscular_atrophy0.76308148
79MP0001346_abnormal_lacrimal_gland0.76044102
80MP0001145_abnormal_male_reproductive0.74296246
81MP0002102_abnormal_ear_morphology0.74215424
82MP0005195_abnormal_posterior_eye0.74043370
83MP0000685_abnormal_immune_system0.73766269
84MP0001905_abnormal_dopamine_level0.73403651
85MP0002229_neurodegeneration0.73401832
86MP0001970_abnormal_pain_threshold0.72718894
87MP0003787_abnormal_imprinting0.72542751
88MP0001929_abnormal_gametogenesis0.72346416
89MP0000358_abnormal_cell_content/0.71633798
90MP0004957_abnormal_blastocyst_morpholog0.70433273
91MP0003011_delayed_dark_adaptation0.70416779
92MP0005386_behavior/neurological_phenoty0.68738449
93MP0004924_abnormal_behavior0.68738449
94MP0008872_abnormal_physiological_respon0.66572945
95MP0005410_abnormal_fertilization0.66317391
96MP0003718_maternal_effect0.66206723
97MP0002971_abnormal_brown_adipose0.65493566
98MP0000371_diluted_coat_color0.65359475
99MP0002063_abnormal_learning/memory/cond0.65311150
100MP0005332_abnormal_amino_acid0.63106891

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.10886177
2Optic neuritis (HP:0100653)6.10886177
3Orchitis (HP:0100796)5.22945745
4Keratoconjunctivitis (HP:0001096)4.53131250
5Myositis (HP:0100614)4.13407552
6True hermaphroditism (HP:0010459)4.13245308
7Keratoconjunctivitis sicca (HP:0001097)3.98988165
8Chronic hepatic failure (HP:0100626)3.98939624
9Poikiloderma (HP:0001029)3.83029508
10Congenital sensorineural hearing impairment (HP:0008527)3.57140554
11Pancreatic cysts (HP:0001737)3.45528424
12Pancreatic fibrosis (HP:0100732)3.43919002
13Abolished electroretinogram (ERG) (HP:0000550)3.25672776
14Abnormality of midbrain morphology (HP:0002418)3.11932519
15Molar tooth sign on MRI (HP:0002419)3.11932519
16Attenuation of retinal blood vessels (HP:0007843)3.08740201
17Congenital stationary night blindness (HP:0007642)3.07509464
18Bilateral sensorineural hearing impairment (HP:0008619)3.07301668
19Encephalitis (HP:0002383)2.94780454
20Bony spicule pigmentary retinopathy (HP:0007737)2.88670396
21Abnormality of the labia minora (HP:0012880)2.87854410
22Keratitis (HP:0000491)2.84409504
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76032282
24Bile duct proliferation (HP:0001408)2.71775800
25Abnormal biliary tract physiology (HP:0012439)2.71775800
26Lower limb hyperreflexia (HP:0002395)2.69497844
27Dyschromatopsia (HP:0007641)2.56789839
28Retinal dysplasia (HP:0007973)2.55183782
29Male pseudohermaphroditism (HP:0000037)2.47895336
30Absent/shortened dynein arms (HP:0200106)2.43251356
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.43251356
32Anorexia (HP:0002039)2.41009466
33Abnormal ciliary motility (HP:0012262)2.40653607
34Recurrent cutaneous fungal infections (HP:0011370)2.30554898
35Chronic mucocutaneous candidiasis (HP:0002728)2.30554898
36Abnormal respiratory epithelium morphology (HP:0012253)2.27023620
37Abnormal respiratory motile cilium morphology (HP:0005938)2.27023620
38Decreased circulating renin level (HP:0003351)2.25581032
39Absent speech (HP:0001344)2.25122971
40Hypoplasia of the uterus (HP:0000013)2.24666497
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23484390
42Horizontal nystagmus (HP:0000666)2.21330697
43Stomatitis (HP:0010280)2.20956391
44Hyperventilation (HP:0002883)2.20573626
45Hyperglycinuria (HP:0003108)2.20090828
46Abnormality of the pericardium (HP:0001697)2.19760116
47Abnormality of the renal cortex (HP:0011035)2.18655644
48Aplasia/hypoplasia of the uterus (HP:0008684)2.16438669
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.14638905
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.10808564
51Abnormal pancreas size (HP:0012094)2.07442728
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06904800
53Gaze-evoked nystagmus (HP:0000640)2.03336373
54Arterial thrombosis (HP:0004420)2.02818277
55Abnormal drinking behavior (HP:0030082)2.02166723
56Polydipsia (HP:0001959)2.02166723
57Nephronophthisis (HP:0000090)2.01119881
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.00606901
59Type II lissencephaly (HP:0007260)1.99951020
60Gangrene (HP:0100758)1.98207210
61Constricted visual fields (HP:0001133)1.97248908
62Hemoptysis (HP:0002105)1.96163884
63Medial flaring of the eyebrow (HP:0010747)1.95382901
64Hypoplastic ischia (HP:0003175)1.93983366
65Gonadotropin excess (HP:0000837)1.93885035
66Gout (HP:0001997)1.93720925
67Abnormality of dental color (HP:0011073)1.93191381
68Tubulointerstitial nephritis (HP:0001970)1.89710667
69Tubular atrophy (HP:0000092)1.89611448
70Hyperglycinemia (HP:0002154)1.88355799
71Sloping forehead (HP:0000340)1.88115944
72Tachypnea (HP:0002789)1.85841643
73Recurrent sinusitis (HP:0011108)1.85158852
74Renal cortical cysts (HP:0000803)1.81657267
75Abnormality of chromosome stability (HP:0003220)1.78106957
76Cystic liver disease (HP:0006706)1.77854069
77Abnormality of the ileum (HP:0001549)1.77005788
78Abnormal respiratory motile cilium physiology (HP:0012261)1.75266976
79Abnormality of the renal medulla (HP:0100957)1.74885444
80Pancreatitis (HP:0001733)1.74714286
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72561366
82Congenital hepatic fibrosis (HP:0002612)1.71648435
83Meckel diverticulum (HP:0002245)1.71534515
84Abnormal rod and cone electroretinograms (HP:0008323)1.70432867
85Large for gestational age (HP:0001520)1.70356154
86Hepatocellular necrosis (HP:0001404)1.68073018
87Patellar aplasia (HP:0006443)1.67199408
88Photophobia (HP:0000613)1.65382362
89Retinitis pigmentosa (HP:0000510)1.65201213
90Fair hair (HP:0002286)1.64885187
91Abnormality of glycine metabolism (HP:0010895)1.64623976
92Abnormality of serine family amino acid metabolism (HP:0010894)1.64623976
93Congenital primary aphakia (HP:0007707)1.64338301
94Glomerulopathy (HP:0100820)1.63694709
95Tinnitus (HP:0000360)1.63541662
96Stomach cancer (HP:0012126)1.62872467
97Oligodactyly (hands) (HP:0001180)1.62491572
98Pulmonary embolism (HP:0002204)1.62004626
99Hepatic necrosis (HP:0002605)1.60229492
100Type II diabetes mellitus (HP:0005978)1.59863176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.30327949
2WNK35.54741535
3TXK3.46551377
4ZAK2.76187454
5PINK12.68370900
6BLK2.27125089
7TAOK32.08029823
8BMPR1B2.03149012
9IRAK11.92188065
10BCKDK1.89136450
11EIF2AK31.84188236
12YES11.84101723
13TLK11.78290814
14NEK91.61203353
15FER1.58805312
16TRIM281.58558971
17MAP3K41.52235454
18BUB11.47792047
19MAP4K21.36931735
20MAPK131.36678775
21PLK41.34884883
22NUAK11.33879953
23MAP2K71.20149663
24CCNB11.17573303
25ERBB31.16235152
26SRPK11.09912966
27MAPKAPK31.09814498
28OXSR11.06568389
29EPHA31.06281434
30CASK1.04772430
31PIK3CA1.02278117
32ACVR1B1.01290943
33EIF2AK20.99489699
34STK38L0.94009883
35TESK20.92128237
36STK390.91536555
37MKNK10.89810679
38ADRBK20.86332789
39MARK10.84094204
40GRK10.83512281
41VRK10.82917560
42RPS6KA50.82779099
43WNK40.82498798
44PLK20.81071037
45DYRK20.77053380
46TTK0.76845980
47GRK50.74977050
48ATR0.74776173
49EPHA40.72631272
50BRSK20.71550230
51TGFBR10.70140215
52NEK60.65817519
53PLK10.65181222
54BCR0.64843413
55CHEK20.62127468
56TEC0.61478471
57MATK0.61018110
58FLT30.60828504
59MUSK0.59956600
60DAPK10.59065011
61NEK10.58561048
62PRKCZ0.58066990
63CSNK1G20.57424709
64MST40.56958717
65TNK20.56323046
66IKBKB0.54689911
67KDR0.53424899
68CSK0.52333218
69MARK30.51988641
70ERBB20.50353412
71CSNK1A1L0.50228152
72MAPKAPK50.48424122
73PAK30.47851535
74ADRBK10.47614918
75MKNK20.46830563
76CSF1R0.45328773
77RAF10.43253377
78NTRK30.43011222
79PLK30.41136005
80EPHB10.40811595
81PKN10.40683267
82PKN20.38467162
83MAP2K40.38187729
84PRKG10.37787404
85CSNK1G30.37215691
86LYN0.36333471
87ATM0.34193595
88GRK70.33322725
89BTK0.32766728
90SYK0.31989276
91EIF2AK10.31734850
92CDK60.31690405
93PRKCQ0.31290619
94ITK0.31199962
95IGF1R0.31166621
96PRKCB0.28671741
97CSNK1G10.27415041
98WEE10.26757121
99JAK10.26602280
100STK160.26353487

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.29438514
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.15129304
3Proteasome_Homo sapiens_hsa030502.81858368
4Propanoate metabolism_Homo sapiens_hsa006402.80574953
5Selenocompound metabolism_Homo sapiens_hsa004502.68401351
6Butanoate metabolism_Homo sapiens_hsa006502.58566293
7Fanconi anemia pathway_Homo sapiens_hsa034602.51887309
8Non-homologous end-joining_Homo sapiens_hsa034502.46880933
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36305192
10Homologous recombination_Homo sapiens_hsa034402.28781630
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28168835
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23551189
13Base excision repair_Homo sapiens_hsa034102.20448272
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.03176102
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98620825
16Nicotine addiction_Homo sapiens_hsa050331.97198117
17Fatty acid metabolism_Homo sapiens_hsa012121.90271256
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79882081
19Linoleic acid metabolism_Homo sapiens_hsa005911.77919820
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.72476496
21Primary immunodeficiency_Homo sapiens_hsa053401.68520812
22Ether lipid metabolism_Homo sapiens_hsa005651.60181946
23DNA replication_Homo sapiens_hsa030301.49974485
24N-Glycan biosynthesis_Homo sapiens_hsa005101.49581036
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47202347
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46474597
27Peroxisome_Homo sapiens_hsa041461.44009487
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39392799
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.34799680
30Dorso-ventral axis formation_Homo sapiens_hsa043201.33790382
31Tryptophan metabolism_Homo sapiens_hsa003801.32774184
32Nitrogen metabolism_Homo sapiens_hsa009101.32571243
33Arachidonic acid metabolism_Homo sapiens_hsa005901.28033632
34Fatty acid degradation_Homo sapiens_hsa000711.27072812
35Phototransduction_Homo sapiens_hsa047441.17476471
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16670052
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11935400
38Mismatch repair_Homo sapiens_hsa034301.11599272
39RNA polymerase_Homo sapiens_hsa030201.08639131
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08548775
41One carbon pool by folate_Homo sapiens_hsa006701.08369167
42Basal transcription factors_Homo sapiens_hsa030221.03926291
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02901254
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.00218770
45Fat digestion and absorption_Homo sapiens_hsa049750.98465195
46Salivary secretion_Homo sapiens_hsa049700.98190435
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96852175
48RNA degradation_Homo sapiens_hsa030180.93748120
49Serotonergic synapse_Homo sapiens_hsa047260.93592211
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93117255
51RNA transport_Homo sapiens_hsa030130.87745326
52Glycerolipid metabolism_Homo sapiens_hsa005610.86847794
53Taste transduction_Homo sapiens_hsa047420.86789658
54Parkinsons disease_Homo sapiens_hsa050120.86208852
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.86106703
56Glutathione metabolism_Homo sapiens_hsa004800.85978924
57Olfactory transduction_Homo sapiens_hsa047400.84490154
58ABC transporters_Homo sapiens_hsa020100.83879142
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82402029
60p53 signaling pathway_Homo sapiens_hsa041150.82360226
61Calcium signaling pathway_Homo sapiens_hsa040200.80616444
62Nucleotide excision repair_Homo sapiens_hsa034200.79068474
63Fatty acid biosynthesis_Homo sapiens_hsa000610.78390416
64Histidine metabolism_Homo sapiens_hsa003400.75201892
65Oxidative phosphorylation_Homo sapiens_hsa001900.73579734
66Systemic lupus erythematosus_Homo sapiens_hsa053220.72227256
67Huntingtons disease_Homo sapiens_hsa050160.69023905
68Metabolic pathways_Homo sapiens_hsa011000.67209742
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66295540
70Lysine degradation_Homo sapiens_hsa003100.65346542
71Vitamin digestion and absorption_Homo sapiens_hsa049770.62311893
72Ovarian steroidogenesis_Homo sapiens_hsa049130.61668626
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61463231
74Morphine addiction_Homo sapiens_hsa050320.60966007
75Pyrimidine metabolism_Homo sapiens_hsa002400.58952312
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58194257
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55931654
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55534784
79Purine metabolism_Homo sapiens_hsa002300.53374180
80Protein export_Homo sapiens_hsa030600.53071405
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46305144
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.43467721
83Long-term depression_Homo sapiens_hsa047300.42793967
84cAMP signaling pathway_Homo sapiens_hsa040240.42623980
85Regulation of autophagy_Homo sapiens_hsa041400.38361842
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36420469
87GABAergic synapse_Homo sapiens_hsa047270.34781958
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34197213
89Antigen processing and presentation_Homo sapiens_hsa046120.29079798
90Epstein-Barr virus infection_Homo sapiens_hsa051690.29079140
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.27668107
92Fatty acid elongation_Homo sapiens_hsa000620.27488437
93Alcoholism_Homo sapiens_hsa050340.27017309
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.25071984
95Staphylococcus aureus infection_Homo sapiens_hsa051500.23028984
96Alzheimers disease_Homo sapiens_hsa050100.21582109
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20473457
98Circadian rhythm_Homo sapiens_hsa047100.19458644
99Biosynthesis of amino acids_Homo sapiens_hsa012300.19021776
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18222497

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