FAM186A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.96164999
2cell-cell recognition (GO:0009988)9.88981807
3reproduction (GO:0000003)9.87699609
4epithelial cilium movement (GO:0003351)9.54207452
5binding of sperm to zona pellucida (GO:0007339)9.53821294
6motile cilium assembly (GO:0044458)8.88508016
7cilium movement (GO:0003341)8.76513801
8male meiosis (GO:0007140)8.65918521
9regulation of cilium movement (GO:0003352)8.64827659
10piRNA metabolic process (GO:0034587)8.62819624
11spermatid development (GO:0007286)8.53033036
12response to pheromone (GO:0019236)8.19420918
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.86503842
14single fertilization (GO:0007338)7.75016979
15synaptonemal complex organization (GO:0070193)7.32817670
16sperm capacitation (GO:0048240)7.24953990
17synaptonemal complex assembly (GO:0007130)7.21335730
18fertilization (GO:0009566)6.42194934
19microtubule depolymerization (GO:0007019)6.21688077
20ventricular system development (GO:0021591)5.98205359
21microtubule severing (GO:0051013)5.70818797
22spermatogenesis (GO:0007283)5.64768613
23establishment of protein localization to Golgi (GO:0072600)5.64559603
24male gamete generation (GO:0048232)5.62640684
25DNA methylation involved in gamete generation (GO:0043046)5.62491738
26male meiosis I (GO:0007141)5.59061649
27protein targeting to Golgi (GO:0000042)5.48533720
28cellular ketone body metabolic process (GO:0046950)5.36003509
29gamete generation (GO:0007276)5.26479255
30negative regulation of inclusion body assembly (GO:0090084)5.18681961
31chromosome organization involved in meiosis (GO:0070192)5.17505417
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.13812520
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.02448160
34organic cation transport (GO:0015695)4.99132746
35meiotic nuclear division (GO:0007126)4.94435197
36spermatid nucleus differentiation (GO:0007289)4.92130405
37germ cell development (GO:0007281)4.92046456
38regulation of microtubule-based movement (GO:0060632)4.88692654
39ketone body metabolic process (GO:1902224)4.86030783
40rRNA methylation (GO:0031167)4.78724593
41protein polyglutamylation (GO:0018095)4.78703240
42cell recognition (GO:0008037)4.78078206
43meiosis I (GO:0007127)4.65551517
44phosphatidylethanolamine biosynthetic process (GO:0006646)4.58530568
45calcium ion-dependent exocytosis (GO:0017156)4.56825323
46monoubiquitinated protein deubiquitination (GO:0035520)4.50236091
47phosphatidylethanolamine metabolic process (GO:0046337)4.34138276
48protein localization to Golgi apparatus (GO:0034067)4.27728382
49rRNA modification (GO:0000154)4.18069719
50regulation of inclusion body assembly (GO:0090083)4.16028913
51behavioral response to nicotine (GO:0035095)4.15895384
52multicellular organismal reproductive process (GO:0048609)4.13757300
53meiotic cell cycle (GO:0051321)4.00307471
54positive regulation of Rab GTPase activity (GO:0032851)3.95450439
55regulation of Rab GTPase activity (GO:0032313)3.95450439
56RNA destabilization (GO:0050779)3.81274855
57protein localization to cilium (GO:0061512)3.69278575
58seminiferous tubule development (GO:0072520)3.53552202
59left/right pattern formation (GO:0060972)3.52288277
60genitalia morphogenesis (GO:0035112)3.45230432
61coenzyme catabolic process (GO:0009109)3.41584515
62microtubule polymerization or depolymerization (GO:0031109)3.38696941
63synapsis (GO:0007129)3.36881322
64intraciliary transport (GO:0042073)3.35553415
65axoneme assembly (GO:0035082)3.30207706
66cilium organization (GO:0044782)3.30030375
67amino-acid betaine transport (GO:0015838)3.29921244
68carnitine transport (GO:0015879)3.29921244
69gene silencing by RNA (GO:0031047)3.28533799
70meiotic cell cycle process (GO:1903046)3.28025942
71carnitine transmembrane transport (GO:1902603)3.25879033
72NAD biosynthetic process (GO:0009435)3.24620061
73sexual reproduction (GO:0019953)3.24215840
74multicellular organismal development (GO:0007275)3.23879799
75microtubule-based movement (GO:0007018)3.23637216
76regulation of spindle checkpoint (GO:0090231)3.22438693
77nuclear pore complex assembly (GO:0051292)3.18810392
78centriole assembly (GO:0098534)3.16535722
79cilium assembly (GO:0042384)3.16410368
80multicellular organismal movement (GO:0050879)3.15961522
81musculoskeletal movement (GO:0050881)3.15961522
82regulation of transcription involved in cell fate commitment (GO:0060850)3.15763421
83centriole replication (GO:0007099)3.14564662
84detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.11516874
85detection of light stimulus involved in visual perception (GO:0050908)3.11443118
86detection of light stimulus involved in sensory perception (GO:0050962)3.11443118
87regulation of centriole replication (GO:0046599)3.09477639
88regulation of meiosis I (GO:0060631)3.09150602
89cellular component assembly involved in morphogenesis (GO:0010927)3.08368972
90cilium morphogenesis (GO:0060271)3.06515126
91spinal cord motor neuron differentiation (GO:0021522)3.06351357
92glycerol ether metabolic process (GO:0006662)3.03693427
93chromosome condensation (GO:0030261)3.01444387
94nephron epithelium morphogenesis (GO:0072088)2.97845106
95nephron tubule morphogenesis (GO:0072078)2.97845106
96protein K11-linked deubiquitination (GO:0035871)2.95994197
97negative regulation of organelle assembly (GO:1902116)2.94226367
98nonmotile primary cilium assembly (GO:0035058)2.93059108
99negative regulation of Rho protein signal transduction (GO:0035024)2.90996848
100single strand break repair (GO:0000012)2.89829060
101microtubule nucleation (GO:0007020)2.88876291
102primary amino compound metabolic process (GO:1901160)2.88607700
103peptidyl-glutamic acid modification (GO:0018200)2.88304871
104nucleus organization (GO:0006997)2.87590674
105DNA packaging (GO:0006323)2.86504352
106positive regulation of action potential (GO:0045760)2.81946503
107chaperone-mediated protein complex assembly (GO:0051131)2.80053277
108indole-containing compound catabolic process (GO:0042436)2.78806676
109indolalkylamine catabolic process (GO:0046218)2.78806676
110tryptophan catabolic process (GO:0006569)2.78806676
111chromatin silencing (GO:0006342)2.78734120
112ether metabolic process (GO:0018904)2.78558020
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69945048
114nucleoside diphosphate phosphorylation (GO:0006165)2.68129419
115L-fucose catabolic process (GO:0042355)2.64783450
116fucose catabolic process (GO:0019317)2.64783450
117L-fucose metabolic process (GO:0042354)2.64783450
118photoreceptor cell maintenance (GO:0045494)2.64614634
119neuronal action potential (GO:0019228)2.61771537
120histone exchange (GO:0043486)2.60524311
121alanine transport (GO:0032328)2.57891411
122left/right axis specification (GO:0070986)2.57643036
123calcium ion import (GO:0070509)2.57631276
124alditol metabolic process (GO:0019400)2.55528875
125indolalkylamine metabolic process (GO:0006586)2.55229318
126lactate metabolic process (GO:0006089)2.54732892
127regulation of action potential (GO:0098900)2.54539203
128polyol catabolic process (GO:0046174)2.51279892
129nuclear pore organization (GO:0006999)2.49063418
130protein localization to chromosome, centromeric region (GO:0071459)2.46464703
131behavioral response to ethanol (GO:0048149)2.45619559
132GTP biosynthetic process (GO:0006183)2.45435016
133peptidyl-threonine dephosphorylation (GO:0035970)2.43529584
134pore complex assembly (GO:0046931)2.42973789
135regulation of acrosome reaction (GO:0060046)2.39900318
136glycolytic process (GO:0006096)2.37244148
137gene silencing (GO:0016458)2.36609166
138fusion of sperm to egg plasma membrane (GO:0007342)13.4928489
139cilium or flagellum-dependent cell motility (GO:0001539)13.4371946
140multicellular organism reproduction (GO:0032504)12.2797951
141acrosome assembly (GO:0001675)11.6995364
142sperm motility (GO:0030317)11.6138744
143cell wall macromolecule metabolic process (GO:0044036)11.3227196
144cell wall macromolecule catabolic process (GO:0016998)11.3227196
145sperm-egg recognition (GO:0035036)11.0746022
146axonemal dynein complex assembly (GO:0070286)10.7361576
147plasma membrane fusion (GO:0045026)10.2352864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.53185455
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.38286730
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.03242471
4EZH2_22144423_ChIP-Seq_EOC_Human3.86379662
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.89259071
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.58397906
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.57750607
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.51541203
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50271824
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45053885
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.43180199
12GBX2_23144817_ChIP-Seq_PC3_Human2.41029028
13KAP1_22055183_ChIP-Seq_ESCs_Mouse2.26958568
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23014023
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22757817
16VDR_22108803_ChIP-Seq_LS180_Human2.14102956
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.11402414
18ER_23166858_ChIP-Seq_MCF-7_Human2.10664619
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.02887891
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.00089626
21P300_19829295_ChIP-Seq_ESCs_Human1.95833643
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.95757469
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.85690619
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.82390065
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.82279880
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.79189233
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.77778864
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.75309728
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.73144129
30ZNF274_21170338_ChIP-Seq_K562_Hela1.70292632
31STAT1_17558387_ChIP-Seq_HELA_Human1.69817440
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69627659
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.67697021
34AR_25329375_ChIP-Seq_VCAP_Human1.66753650
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.64145206
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62893222
37RNF2_27304074_Chip-Seq_NSC_Mouse1.62889929
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61021468
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59494601
40TAL1_26923725_Chip-Seq_HPCs_Mouse1.58352589
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55260668
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52483296
43AR_21572438_ChIP-Seq_LNCaP_Human1.52432554
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52255531
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.51961851
46KDM2B_26808549_Chip-Seq_REH_Human1.51536601
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.50138103
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.49863877
49STAT3_23295773_ChIP-Seq_U87_Human1.47995254
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.47830919
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47768197
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47678082
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46175850
54IGF1R_20145208_ChIP-Seq_DFB_Human1.46033087
55SMAD4_21799915_ChIP-Seq_A2780_Human1.45590131
56ERA_21632823_ChIP-Seq_H3396_Human1.44716315
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.44476610
58DROSHA_22980978_ChIP-Seq_HELA_Human1.42737202
59RUNX1_26923725_Chip-Seq_HPCs_Mouse1.42101349
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.41887496
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.41697712
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41357049
63OCT4_18555785_Chip-Seq_ESCs_Mouse1.41307239
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.40911168
65NANOG_19829295_ChIP-Seq_ESCs_Human1.40722888
66SOX2_19829295_ChIP-Seq_ESCs_Human1.40722888
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38178597
68RUNX2_22187159_ChIP-Seq_PCA_Human1.38163970
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37389013
70MYC_19829295_ChIP-Seq_ESCs_Human1.36684300
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.36647743
72NANOG_20526341_ChIP-Seq_ESCs_Human1.36602636
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33908611
74FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33588939
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33275689
76CBP_20019798_ChIP-Seq_JUKART_Human1.33275689
77* TCF4_23295773_ChIP-Seq_U87_Human1.32526338
78GF1_26923725_Chip-Seq_HPCs_Mouse1.32482616
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32050960
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32050960
81GATA3_21867929_ChIP-Seq_CD8_Mouse1.31627494
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31615057
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.30826157
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30601696
85ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30374577
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30105373
87P53_22387025_ChIP-Seq_ESCs_Mouse1.28877587
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28776868
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28292208
90TAF2_19829295_ChIP-Seq_ESCs_Human1.28220487
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27859194
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27816899
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27812413
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.27505255
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27488489
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.27423113
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.26436566
98P300_18555785_Chip-Seq_ESCs_Mouse1.26281461
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26273571
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.26191317
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.25317210
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.25221240
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23025749
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.23025749
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22900556
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22578447
107EWS_26573619_Chip-Seq_HEK293_Human1.22110997
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22004605
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21908360
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20745890
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19827223
112LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19411186
113TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18848805
114RBPJ_21746931_ChIP-Seq_IB4_Human1.18484283
115CTCF_18555785_Chip-Seq_ESCs_Mouse1.18147514
116TCF4_22108803_ChIP-Seq_LS180_Human1.18048020
117BCAT_22108803_ChIP-Seq_LS180_Human1.17843611
118HOXB7_26014856_ChIP-Seq_BT474_Human1.17803376
119SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17600296
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.17047106
121SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16969971
122RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16588926
123NCOR_22424771_ChIP-Seq_293T_Human1.16425834
124* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16195282
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16082532
126CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15951798
127PHF8_20622853_ChIP-Seq_HELA_Human1.15112053
128HNFA_21074721_ChIP-Seq_CACO-2_Human1.15066573
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13873643
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.13654647
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13287319
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.13245520
133CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13051493
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12986113
135RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12959196
136OCT4_20526341_ChIP-Seq_ESCs_Human1.12456327
137GF1B_26923725_Chip-Seq_HPCs_Mouse1.12412207
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11958521
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09798843
140RAC3_21632823_ChIP-Seq_H3396_Human1.09637975
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09600548
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08762439
143CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08734435
144TP53_18474530_ChIP-ChIP_U2OS_Human1.08502743
145ZFX_18555785_Chip-Seq_ESCs_Mouse1.06870462
146NFYA_21822215_ChIP-Seq_K562_Human1.06535346
147PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06463649
148SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06387005
149TP53_22573176_ChIP-Seq_HFKS_Human1.05732536
150FOXH1_21741376_ChIP-Seq_EPCs_Human1.05123373
151SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05025149
152TAF15_26573619_Chip-Seq_HEK293_Human1.04575671
153NMYC_18555785_Chip-Seq_ESCs_Mouse1.03469561
154SPI1_26923725_Chip-Seq_HPCs_Mouse1.01103943
155TBL1_22424771_ChIP-Seq_293T_Human1.00549449
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.99626383
157PU1_27457419_Chip-Seq_LIVER_Mouse0.99437836
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98926869
159STAT3_18555785_ChIP-Seq_MESCs_Mouse0.98888183
160NFYB_21822215_ChIP-Seq_K562_Human0.98714812
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97365927
162P53_21459846_ChIP-Seq_SAOS-2_Human0.96572251
163REST_21632747_ChIP-Seq_MESCs_Mouse0.94011675
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93968945
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93719170
166ERG_20517297_ChIP-Seq_VCAP_Human0.93471135
167FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93300283
168FOXM1_23109430_ChIP-Seq_U2OS_Human0.93041665
169EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92339624
170CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91803743
171OCT1_27270436_Chip-Seq_PROSTATE_Human0.86862445
172FUS_26573619_Chip-Seq_HEK293_Human0.86227214
173ETV1_20927104_ChIP-Seq_GIST48_Human0.85366654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.67105177
2MP0001929_abnormal_gametogenesis5.30943444
3MP0008877_abnormal_DNA_methylation4.72898764
4MP0002653_abnormal_ependyma_morphology4.31357388
5MP0002210_abnormal_sex_determination3.71757560
6MP0005623_abnormal_meninges_morphology3.28098397
7MP0002161_abnormal_fertility/fecundity3.18528705
8MP0001145_abnormal_male_reproductive3.10147689
9MP0000653_abnormal_sex_gland2.86784682
10MP0002282_abnormal_trachea_morphology2.35198027
11MP0001968_abnormal_touch/_nociception2.17967513
12MP0001486_abnormal_startle_reflex2.06807839
13MP0008058_abnormal_DNA_repair2.00928067
14MP0005410_abnormal_fertilization13.8945268
15MP0001485_abnormal_pinna_reflex1.94286496
16MP0005670_abnormal_white_adipose1.92312110
17MP0003646_muscle_fatigue1.81914945
18MP0003195_calcinosis1.79716552
19MP0002138_abnormal_hepatobiliary_system1.77093433
20MP0009046_muscle_twitch1.75250051
21MP0001348_abnormal_lacrimal_gland1.73005040
22MP0006292_abnormal_olfactory_placode1.70434037
23MP0001984_abnormal_olfaction1.66442319
24MP0002736_abnormal_nociception_after1.62993002
25MP0003787_abnormal_imprinting1.57899351
26MP0009745_abnormal_behavioral_response1.56564794
27MP0002735_abnormal_chemical_nociception1.54741888
28MP0002102_abnormal_ear_morphology1.51207355
29MP0004885_abnormal_endolymph1.50258927
30MP0002160_abnormal_reproductive_system1.49817135
31MP0010094_abnormal_chromosome_stability1.46569718
32MP0006276_abnormal_autonomic_nervous1.40128922
33MP0005647_abnormal_sex_gland1.37420857
34MP0003136_yellow_coat_color1.36016768
35MP0005423_abnormal_somatic_nervous1.34635897
36MP0002272_abnormal_nervous_system1.34262563
37MP0004142_abnormal_muscle_tone1.32417423
38MP0002572_abnormal_emotion/affect_behav1.30880459
39MP0008872_abnormal_physiological_respon1.28677032
40MP0008057_abnormal_DNA_replication1.27521603
41MP0004043_abnormal_pH_regulation1.26673909
42MP0000372_irregular_coat_pigmentation1.24767060
43MP0001905_abnormal_dopamine_level1.22956404
44MP0008875_abnormal_xenobiotic_pharmacok1.22780342
45MP0002733_abnormal_thermal_nociception1.22544550
46MP0000026_abnormal_inner_ear1.20720999
47MP0002557_abnormal_social/conspecific_i1.18587898
48MP0001970_abnormal_pain_threshold1.18446206
49MP0005084_abnormal_gallbladder_morpholo1.18200213
50MP0001963_abnormal_hearing_physiology1.17594282
51MP0002067_abnormal_sensory_capabilities1.16741613
52MP0002876_abnormal_thyroid_physiology1.16309049
53MP0001501_abnormal_sleep_pattern1.16253236
54MP0001986_abnormal_taste_sensitivity1.15733518
55MP0005646_abnormal_pituitary_gland1.12805563
56MP0002229_neurodegeneration1.09815846
57MP0010386_abnormal_urinary_bladder1.09788813
58MP0005645_abnormal_hypothalamus_physiol1.08849404
59MP0002638_abnormal_pupillary_reflex1.06997179
60MP0004381_abnormal_hair_follicle1.04670925
61MP0001529_abnormal_vocalization1.04638553
62MP0003950_abnormal_plasma_membrane1.04218631
63MP0008995_early_reproductive_senescence0.99386942
64MP0003111_abnormal_nucleus_morphology0.99126250
65MP0000230_abnormal_systemic_arterial0.95661976
66MP0003880_abnormal_central_pattern0.95000119
67MP0002064_seizures0.93866333
68MP0003635_abnormal_synaptic_transmissio0.93503573
69MP0003699_abnormal_female_reproductive0.91305625
70MP0001440_abnormal_grooming_behavior0.91205006
71MP0005310_abnormal_salivary_gland0.88939370
72MP0002734_abnormal_mechanical_nocicepti0.87946264
73MP0002132_abnormal_respiratory_system0.87563849
74MP0000631_abnormal_neuroendocrine_gland0.86771401
75MP0003718_maternal_effect0.86514989
76MP0004133_heterotaxia0.86143750
77MP0004085_abnormal_heartbeat0.85871428
78MP0002938_white_spotting0.84632915
79MP0001765_abnormal_ion_homeostasis0.82849368
80MP0001119_abnormal_female_reproductive0.82498592
81MP0005367_renal/urinary_system_phenotyp0.81960677
82MP0000516_abnormal_urinary_system0.81960677
83MP0005195_abnormal_posterior_eye0.81870294
84MP0002822_catalepsy0.81585117
85MP0005389_reproductive_system_phenotype0.78098963
86MP0003011_delayed_dark_adaptation0.77953704
87MP0000383_abnormal_hair_follicle0.75643387
88MP0004233_abnormal_muscle_weight0.75153595
89MP0000955_abnormal_spinal_cord0.74928159
90MP0008007_abnormal_cellular_replicative0.74776040
91MP0004859_abnormal_synaptic_plasticity0.74419485
92MP0000647_abnormal_sebaceous_gland0.74234869
93MP0002928_abnormal_bile_duct0.74086508
94MP0002063_abnormal_learning/memory/cond0.74074866
95MP0003137_abnormal_impulse_conducting0.73428643
96MP0004924_abnormal_behavior0.73247777
97MP0005386_behavior/neurological_phenoty0.73247777
98MP0000049_abnormal_middle_ear0.72327449
99MP0005451_abnormal_body_composition0.71238653
100MP0000678_abnormal_parathyroid_gland0.71078462
101MP0005174_abnormal_tail_pigmentation0.69773716
102MP0003283_abnormal_digestive_organ0.69637870
103MP0005167_abnormal_blood-brain_barrier0.69055152
104MP0008569_lethality_at_weaning0.65028507
105MP0002163_abnormal_gland_morphology0.64665931
106MP0000427_abnormal_hair_cycle0.64222772
107MP0005377_hearing/vestibular/ear_phenot0.61312853
108MP0003878_abnormal_ear_physiology0.61312853
109MP0003786_premature_aging0.59548771
110MP0000579_abnormal_nail_morphology0.59516313
111MP0002837_dystrophic_cardiac_calcinosis0.56478164
112MP0009250_abnormal_appendicular_skeleto0.52718354
113MP0000566_synostosis0.51813482
114MP0003077_abnormal_cell_cycle0.51362232
115MP0002249_abnormal_larynx_morphology0.49452516
116MP0005666_abnormal_adipose_tissue0.48670066
117MP0005409_darkened_coat_color0.48267822
118MP0004036_abnormal_muscle_relaxation0.47139825
119MP0001293_anophthalmia0.46685082
120MP0003937_abnormal_limbs/digits/tail_de0.42349414
121MP0000432_abnormal_head_morphology0.42150075
122MP0004084_abnormal_cardiac_muscle0.41491587
123MP0010678_abnormal_skin_adnexa0.41097192
124MP0005551_abnormal_eye_electrophysiolog0.40108371
125MP0005395_other_phenotype0.39962820
126MP0002234_abnormal_pharynx_morphology0.39914360
127MP0003115_abnormal_respiratory_system0.39674665
128MP0002971_abnormal_brown_adipose0.39121719
129MP0003861_abnormal_nervous_system0.38831580
130MP0005253_abnormal_eye_physiology0.38593324
131MP0005636_abnormal_mineral_homeostasis0.37242658
132MP0005391_vision/eye_phenotype0.34976943
133MP0002233_abnormal_nose_morphology0.34853113
134MP0000569_abnormal_digit_pigmentation0.32843533
135MP0002269_muscular_atrophy0.32524977
136MP0005187_abnormal_penis_morphology0.32466131
137MP0002084_abnormal_developmental_patter0.32261152
138MP0001730_embryonic_growth_arrest0.32181868
139MP0006138_congestive_heart_failure0.31407440
140MP0005379_endocrine/exocrine_gland_phen0.31302656
141MP0005380_embryogenesis_phenotype0.30334122
142MP0001672_abnormal_embryogenesis/_devel0.30334122
143MP0006072_abnormal_retinal_apoptosis0.30297507
144MP0002116_abnormal_craniofacial_bone0.30083302
145MP0003693_abnormal_embryo_hatching0.29548767
146MP0005365_abnormal_bile_salt0.28277415
147MP0004019_abnormal_vitamin_homeostasis0.27895249
148MP0000358_abnormal_cell_content/0.27701630
149MP0002085_abnormal_embryonic_tissue0.26858318
150MP0002796_impaired_skin_barrier0.26397503
151MP0002139_abnormal_hepatobiliary_system0.26027859
152MP0002295_abnormal_pulmonary_circulatio0.25999419
153MP0004134_abnormal_chest_morphology0.25852426
154MP0003942_abnormal_urinary_system0.25581952
155MP0009115_abnormal_fat_cell0.25390935
156MP0002109_abnormal_limb_morphology0.24728844
157MP0010307_abnormal_tumor_latency0.24143457
158MP0004742_abnormal_vestibular_system0.23529884
159MP0002127_abnormal_cardiovascular_syste0.23499001
160MP0003936_abnormal_reproductive_system0.23020520
161MP0002752_abnormal_somatic_nervous0.22474178
162MP0003755_abnormal_palate_morphology0.22097693
163MP0000751_myopathy0.21895213

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.64547121
2Abnormal respiratory epithelium morphology (HP:0012253)8.60841295
3Abnormal respiratory motile cilium morphology (HP:0005938)8.60841295
4Abnormal ciliary motility (HP:0012262)8.28372443
5Rhinitis (HP:0012384)7.81096427
6Chronic bronchitis (HP:0004469)6.57483006
7Nasal polyposis (HP:0100582)6.04224164
8Infertility (HP:0000789)5.82568798
9Severe visual impairment (HP:0001141)5.14182724
10Male infertility (HP:0003251)5.13348828
11Abnormality of the nasal mucosa (HP:0000433)4.88221806
12Attenuation of retinal blood vessels (HP:0007843)4.84787298
13Bronchiectasis (HP:0002110)4.52053724
14Bony spicule pigmentary retinopathy (HP:0007737)4.24763935
15Bronchitis (HP:0012387)4.22783198
16Abnormal rod and cone electroretinograms (HP:0008323)4.05517033
17Nephronophthisis (HP:0000090)4.01424670
18Congenital stationary night blindness (HP:0007642)3.89716113
19Recurrent sinusitis (HP:0011108)3.49167252
20Abnormal spermatogenesis (HP:0008669)3.48779812
21Abnormality of macular pigmentation (HP:0008002)3.44756810
22Recurrent otitis media (HP:0000403)3.29104143
23Abnormality of the renal medulla (HP:0100957)3.02089484
24Molar tooth sign on MRI (HP:0002419)2.90609992
25Abnormality of midbrain morphology (HP:0002418)2.90609992
26Hypoplastic ischia (HP:0003175)2.86614023
27Medial flaring of the eyebrow (HP:0010747)2.84202675
28Polyuria (HP:0000103)2.81530893
29Abnormal urine output (HP:0012590)2.73571241
30Progressive cerebellar ataxia (HP:0002073)2.72274434
31Amelogenesis imperfecta (HP:0000705)2.72131794
32Recurrent bronchitis (HP:0002837)2.66316660
33Tubulointerstitial nephritis (HP:0001970)2.60351727
34Impulsivity (HP:0100710)2.60346197
35Hyperkalemia (HP:0002153)2.59856536
36Type II lissencephaly (HP:0007260)2.56478117
37Azoospermia (HP:0000027)2.52695321
38Microglossia (HP:0000171)2.50873992
39Pendular nystagmus (HP:0012043)2.50712228
40Tubular atrophy (HP:0000092)2.50693150
41Potter facies (HP:0002009)2.49142410
42Facial shape deformation (HP:0011334)2.49142410
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.47668396
44Abnormality of the ischium (HP:0003174)2.43533916
45Congenital sensorineural hearing impairment (HP:0008527)2.41805864
46Tubulointerstitial abnormality (HP:0001969)2.33630901
47Increased corneal curvature (HP:0100692)2.32209340
48Keratoconus (HP:0000563)2.32209340
49Abolished electroretinogram (ERG) (HP:0000550)2.27253077
50Fibular hypoplasia (HP:0003038)2.23338433
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.22049773
52Cerebellar dysplasia (HP:0007033)2.20370527
53Pancreatic fibrosis (HP:0100732)2.19923220
54Sclerocornea (HP:0000647)2.17189333
55Postaxial foot polydactyly (HP:0001830)2.14742741
56Anencephaly (HP:0002323)2.10295509
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07479685
58Hypoplasia of the thymus (HP:0000778)2.05472776
59Tongue fasciculations (HP:0001308)2.05119207
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04521531
61Abnormality of potassium homeostasis (HP:0011042)2.04088488
62Decreased circulating renin level (HP:0003351)2.03081070
63Bulbous nose (HP:0000414)2.02960968
64Congenital hepatic fibrosis (HP:0002612)2.02801737
65Abnormality of dental color (HP:0011073)2.01127946
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8734542
67Dynein arm defect of respiratory motile cilia (HP:0012255)11.9716477
68Absent/shortened dynein arms (HP:0200106)11.9716477
69Enlarged epiphyses (HP:0010580)1.99496541
70Decreased central vision (HP:0007663)1.98860811
71Abnormality of the lower motor neuron (HP:0002366)1.98618593
72Bile duct proliferation (HP:0001408)1.97499430
73Abnormal biliary tract physiology (HP:0012439)1.97499430
74Muscle fibrillation (HP:0010546)1.96806473
75Supernumerary spleens (HP:0009799)1.95260586
76Abnormality of permanent molar morphology (HP:0011071)1.94656150
77Abnormality of the dental root (HP:0006486)1.94656150
78Taurodontia (HP:0000679)1.94656150
79Scotoma (HP:0000575)1.92658045
80Tubulointerstitial fibrosis (HP:0005576)1.92322580
81Abnormality of molar morphology (HP:0011070)1.91644708
82Abnormality of molar (HP:0011077)1.91644708
83Generalized aminoaciduria (HP:0002909)1.90835298
84Abnormality of the aortic arch (HP:0012303)1.89060224
85Photophobia (HP:0000613)1.88101209
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.87245215
87Large for gestational age (HP:0001520)1.85730746
88Short ribs (HP:0000773)1.84216025
89Hypokalemia (HP:0002900)1.79037752
90Facial cleft (HP:0002006)1.78122258
91Type II diabetes mellitus (HP:0005978)1.77065510
92Chronic sinusitis (HP:0011109)1.76474937
93Abnormal albumin level (HP:0012116)1.75087041
94Hypoalbuminemia (HP:0003073)1.75087041
95Chorioretinal atrophy (HP:0000533)1.74331875
96Abnormality of the dental pulp (HP:0006479)1.72711623
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72575280
98Median cleft lip (HP:0000161)1.72448739
99Gaze-evoked nystagmus (HP:0000640)1.72322152
100Hyperventilation (HP:0002883)1.71774867
101Asymmetric septal hypertrophy (HP:0001670)1.71031213
102Type 2 muscle fiber atrophy (HP:0003554)1.69991875
103Stage 5 chronic kidney disease (HP:0003774)1.69878013
104Inability to walk (HP:0002540)1.69233574
105Gait imbalance (HP:0002141)1.68658998
106Congenital primary aphakia (HP:0007707)1.68426765
107Heterotopia (HP:0002282)1.68131104
108Renal dysplasia (HP:0000110)1.67964071
109Optic disc pallor (HP:0000543)1.67284719
110Abnormality of the labia minora (HP:0012880)1.67237516
111Postaxial hand polydactyly (HP:0001162)1.67228437
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.66697843
113Postural instability (HP:0002172)1.66665478
114Absent frontal sinuses (HP:0002688)1.66665274
115Polydipsia (HP:0001959)1.64981859
116Abnormal drinking behavior (HP:0030082)1.64981859
117Oculomotor apraxia (HP:0000657)1.62702311
118Abnormality of the renal cortex (HP:0011035)1.62408906
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60019344
120Cystic liver disease (HP:0006706)1.59781062
121Gonadotropin excess (HP:0000837)1.59216874
122True hermaphroditism (HP:0010459)1.57268396
123Genital tract atresia (HP:0001827)1.51610172
124Absent epiphyses (HP:0010577)1.49880820
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49880820
126Cone-rod dystrophy (HP:0000548)1.47250879
127Short thorax (HP:0010306)1.45808195
128Cholecystitis (HP:0001082)1.44066932
129Abnormal gallbladder physiology (HP:0012438)1.44066932
130Nephroblastoma (Wilms tumor) (HP:0002667)1.43333082
131Aplasia/Hypoplasia of the fibula (HP:0006492)1.43268428
132Occipital encephalocele (HP:0002085)1.43257273
133Abnormality of lateral ventricle (HP:0030047)1.42990628
134Abnormality of dentin (HP:0010299)1.41797555
135Vaginal atresia (HP:0000148)1.40473954
136Nephrogenic diabetes insipidus (HP:0009806)1.40212245
137Abnormality of saccadic eye movements (HP:0000570)1.39994829
138Spastic tetraparesis (HP:0001285)1.38463000
139Pancreatic cysts (HP:0001737)1.37453979
140Absent eyebrow (HP:0002223)1.37138777
141Bell-shaped thorax (HP:0001591)1.36290143
142Spontaneous abortion (HP:0005268)1.34094441
143Amyotrophic lateral sclerosis (HP:0007354)1.34053678
144J-shaped sella turcica (HP:0002680)1.31401976
145Aplasia/Hypoplasia of the lens (HP:0008063)1.30909371
146Poor coordination (HP:0002370)1.29857499
147Embryonal renal neoplasm (HP:0011794)1.29826265
148Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29264215
149Male pseudohermaphroditism (HP:0000037)1.27209932
150Abnormality of renal excretion (HP:0011036)1.27075360
151Chronic hepatic failure (HP:0100626)1.26391192
152Broad distal phalanx of finger (HP:0009836)1.21107505
153Optic nerve hypoplasia (HP:0000609)1.20963993
154Impaired proprioception (HP:0010831)1.17447884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.93416259
2PDK47.93416259
3PDK25.06981503
4PRKD35.04040062
5FRK4.88314663
6INSRR4.03005558
7MAP4K23.90577191
8TESK13.78894532
9ICK3.20246832
10PLK22.61279937
11PNCK2.55738718
12TAOK32.50483032
13STK392.49227994
14WNK42.43394949
15PTK2B2.35128289
16ADRBK22.23709049
17NUAK12.13872606
18STK38L1.98076428
19WNK31.88278122
20STK381.80550601
21PIK3CG1.67301575
22NEK21.63579309
23TTK1.56362895
24BRSK21.54844588
25WEE11.45358913
26OXSR11.38600705
27MARK11.31333267
28BRD41.28068786
29STK31.27588410
30AKT31.21695204
31TAF11.19498565
32TXK1.18616164
33LATS11.15779503
34TYRO31.14390367
35CHEK21.13544412
36TLK11.11287135
37CASK1.10008803
38NTRK31.08662055
39TNIK1.02667915
40DYRK30.97243627
41CDK120.95211094
42PLK40.94791370
43CAMK1G0.88689552
44MUSK0.88276495
45WNK10.87705884
46DYRK1B0.84739997
47LATS20.83679491
48PDK10.82462461
49ADRBK10.81363305
50CDC70.79811812
51PINK10.78266562
52MAPK150.76086762
53CHEK10.70561919
54LMTK20.70511374
55PLK10.69135172
56MKNK20.65884468
57PAK30.62077895
58PRKCE0.60930227
59TGFBR10.60452593
60CAMK1D0.60423402
61BRSK10.59660489
62PRKCH0.59183337
63CAMK10.57681663
64DAPK20.56413282
65SIK20.53847875
66GRK10.53752569
67TRIM280.53312313
68NEK60.52366321
69CCNB10.52170297
70MAPKAPK30.51885171
71ATM0.51492136
72PRKCZ0.50912586
73TIE10.49308479
74MAP2K70.48226513
75BCKDK0.46326493
76KIT0.46237856
77PRKAA10.45043078
78ATR0.43600215
79PRKACA0.42446328
80NLK0.40028356
81MAPKAPK50.38899191
82MAP2K20.38756116
83TEC0.37921521
84EEF2K0.37718991
85IKBKB0.37106438
86PRKG20.35280499
87VRK10.35159061
88IRAK10.35015087
89PAK10.34843420
90MAP3K60.34044253
91ERBB30.33852900
92FER0.33218801
93SGK20.32477860
94MAP3K110.32290141
95PKN10.31508912
96ROCK10.31413706
97MTOR0.31384349
98SGK2230.30522724
99SGK4940.30522724
100NME10.30356669
101BMPR1B0.30018672
102CDK30.29811067
103RIPK10.29265568
104NTRK20.29159910
105TNK20.29009646
106STK100.28871175
107PRKCB0.28611792
108GRK70.28527207
109PDPK10.27343324
110PRKCA0.26635305
111ACVR1B0.26334852
112PRKCG0.25656739
113BUB10.25320136
114ERBB40.24499228
115MARK20.23309843
116AURKA0.22250046
117STK110.21799164
118AURKB0.21104123
119MARK30.21100185
120MAP2K60.21073511
121EIF2AK20.20639919
122TAOK10.20619706
123OBSCN0.20384671
124TESK20.20365575
125CDK10.20278220
126PBK0.20228258
127BRAF0.19446468
128MOS0.19344321
129CDK70.18458601
130PLK30.17432657
131CDK20.15941604
132DYRK20.15003462
133ZAK0.14811563
134PRKAA20.14696653
135CSNK1D0.14561344
136PDGFRB0.14352421
137PASK0.14142451
138CDK40.14119210
139PAK20.13893644
140GSK3B0.12585637
141MAP3K40.12526528
142FGFR20.12441654
143PRKG10.12031289
144DDR20.11718938
145EPHB20.11461617
146BMPR20.10494461
147MAPK130.10171790
148PRKCQ0.10168554
149CSNK2A20.10145051
150STK240.09511183
151CSNK2A10.08893633
152PHKG20.08253266
153PHKG10.08253266
154MAPK100.07989100
155CAMK2A0.07748779

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.23463138
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.11632012
3Fatty acid biosynthesis_Homo sapiens_hsa000613.67819791
4Basal transcription factors_Homo sapiens_hsa030223.34346439
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.29055827
6Butanoate metabolism_Homo sapiens_hsa006503.16672515
7Pyruvate metabolism_Homo sapiens_hsa006203.13926458
8Propanoate metabolism_Homo sapiens_hsa006403.12464375
9Pentose phosphate pathway_Homo sapiens_hsa000302.98200108
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87035512
11Fanconi anemia pathway_Homo sapiens_hsa034602.85309788
12Linoleic acid metabolism_Homo sapiens_hsa005912.84239075
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.21954683
14Glucagon signaling pathway_Homo sapiens_hsa049222.15905932
15Nicotine addiction_Homo sapiens_hsa050332.14521140
16Nitrogen metabolism_Homo sapiens_hsa009102.13215646
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.12319293
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.10933059
19Oocyte meiosis_Homo sapiens_hsa041142.05770847
20Dorso-ventral axis formation_Homo sapiens_hsa043202.04270581
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.79799154
22Glycerolipid metabolism_Homo sapiens_hsa005611.72336421
23PPAR signaling pathway_Homo sapiens_hsa033201.69248452
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67372142
25Ether lipid metabolism_Homo sapiens_hsa005651.67294209
26RNA transport_Homo sapiens_hsa030131.62473560
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58212284
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57234849
29Huntingtons disease_Homo sapiens_hsa050161.55378828
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52080349
31Selenocompound metabolism_Homo sapiens_hsa004501.42088600
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37027643
33Morphine addiction_Homo sapiens_hsa050321.36533865
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.35516312
35Fatty acid metabolism_Homo sapiens_hsa012121.32295327
36Tryptophan metabolism_Homo sapiens_hsa003801.31903001
37Carbon metabolism_Homo sapiens_hsa012001.31536159
38Type I diabetes mellitus_Homo sapiens_hsa049401.30279712
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.29347022
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26722938
41Oxidative phosphorylation_Homo sapiens_hsa001901.24938089
42mRNA surveillance pathway_Homo sapiens_hsa030151.24784899
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.23376659
44Fatty acid degradation_Homo sapiens_hsa000711.22816951
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21486009
46Lysine degradation_Homo sapiens_hsa003101.20669009
47Homologous recombination_Homo sapiens_hsa034401.20527873
48Renin-angiotensin system_Homo sapiens_hsa046141.17209396
49Biosynthesis of amino acids_Homo sapiens_hsa012301.16748692
50Graft-versus-host disease_Homo sapiens_hsa053321.15087300
51Purine metabolism_Homo sapiens_hsa002301.14740498
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13827265
53Allograft rejection_Homo sapiens_hsa053301.13358447
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12938432
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10999582
56Cell cycle_Homo sapiens_hsa041101.09102539
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08984634
58Autoimmune thyroid disease_Homo sapiens_hsa053201.08586448
59Serotonergic synapse_Homo sapiens_hsa047261.08197020
60Mineral absorption_Homo sapiens_hsa049781.06004245
61RNA polymerase_Homo sapiens_hsa030201.04942900
62Fat digestion and absorption_Homo sapiens_hsa049751.04421618
63Caffeine metabolism_Homo sapiens_hsa002321.03460823
64Cardiac muscle contraction_Homo sapiens_hsa042600.99778483
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97549867
66Circadian entrainment_Homo sapiens_hsa047130.95568789
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93805955
68Amphetamine addiction_Homo sapiens_hsa050310.93660791
69Glutamatergic synapse_Homo sapiens_hsa047240.93340506
70Ovarian steroidogenesis_Homo sapiens_hsa049130.92997232
71Hedgehog signaling pathway_Homo sapiens_hsa043400.92903404
72Taste transduction_Homo sapiens_hsa047420.91759664
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91695867
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91100967
75Parkinsons disease_Homo sapiens_hsa050120.90809794
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.90285028
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90214204
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86947440
79Renin secretion_Homo sapiens_hsa049240.86622809
80Arachidonic acid metabolism_Homo sapiens_hsa005900.85428972
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84471488
82Olfactory transduction_Homo sapiens_hsa047400.83700958
83Fructose and mannose metabolism_Homo sapiens_hsa000510.82374537
84Peroxisome_Homo sapiens_hsa041460.81204992
85Glutathione metabolism_Homo sapiens_hsa004800.73392661
86Type II diabetes mellitus_Homo sapiens_hsa049300.70113068
87GABAergic synapse_Homo sapiens_hsa047270.69863124
88Regulation of autophagy_Homo sapiens_hsa041400.66643990
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66604565
90Chemical carcinogenesis_Homo sapiens_hsa052040.63743370
91Protein digestion and absorption_Homo sapiens_hsa049740.61989160
92ABC transporters_Homo sapiens_hsa020100.61668300
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59784044
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56943701
95Retinol metabolism_Homo sapiens_hsa008300.56323600
96RNA degradation_Homo sapiens_hsa030180.55083772
97Calcium signaling pathway_Homo sapiens_hsa040200.53502199
98Phototransduction_Homo sapiens_hsa047440.51468044
99Estrogen signaling pathway_Homo sapiens_hsa049150.51183735
100Inositol phosphate metabolism_Homo sapiens_hsa005620.51109147
101Alzheimers disease_Homo sapiens_hsa050100.50978830
102Primary immunodeficiency_Homo sapiens_hsa053400.50660844
103Bile secretion_Homo sapiens_hsa049760.49151035
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.47128543
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46949658
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46898672
107Metabolic pathways_Homo sapiens_hsa011000.46392150
108Cholinergic synapse_Homo sapiens_hsa047250.45825553
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43247086
110Gastric acid secretion_Homo sapiens_hsa049710.43212133
111Basal cell carcinoma_Homo sapiens_hsa052170.42828535
112Arginine and proline metabolism_Homo sapiens_hsa003300.42577750
113beta-Alanine metabolism_Homo sapiens_hsa004100.42125130
114Asthma_Homo sapiens_hsa053100.41514692
115Synaptic vesicle cycle_Homo sapiens_hsa047210.40720121
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40587902
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40401046
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40260215
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40038876
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.39670931
121Insulin secretion_Homo sapiens_hsa049110.39308137
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39023922
123Systemic lupus erythematosus_Homo sapiens_hsa053220.37049965
124cAMP signaling pathway_Homo sapiens_hsa040240.36796118
125AMPK signaling pathway_Homo sapiens_hsa041520.36404683
126Vitamin digestion and absorption_Homo sapiens_hsa049770.35814896
127Thyroid hormone synthesis_Homo sapiens_hsa049180.35466315
128Tyrosine metabolism_Homo sapiens_hsa003500.34151790
129p53 signaling pathway_Homo sapiens_hsa041150.33682367
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32317448
131Oxytocin signaling pathway_Homo sapiens_hsa049210.32234698
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30988973
133Histidine metabolism_Homo sapiens_hsa003400.30686523
134Sulfur relay system_Homo sapiens_hsa041220.28538539
135Complement and coagulation cascades_Homo sapiens_hsa046100.28169768
136Antigen processing and presentation_Homo sapiens_hsa046120.26818162
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.26700271
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24431363
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23314101
140Pyrimidine metabolism_Homo sapiens_hsa002400.23242648
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22329430
142Pancreatic secretion_Homo sapiens_hsa049720.20568029
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.18799369
144Endocytosis_Homo sapiens_hsa041440.18293445
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17110572
146ECM-receptor interaction_Homo sapiens_hsa045120.15273503
147Wnt signaling pathway_Homo sapiens_hsa043100.14175231
148Long-term potentiation_Homo sapiens_hsa047200.13234770
149Cocaine addiction_Homo sapiens_hsa050300.12319343
150Salivary secretion_Homo sapiens_hsa049700.11804328

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