FAM186B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.86405150
2plasma membrane fusion (GO:0045026)9.75728391
3epithelial cilium movement (GO:0003351)9.73814249
4cell wall macromolecule metabolic process (GO:0044036)9.71645374
5cell wall macromolecule catabolic process (GO:0016998)9.71645374
6motile cilium assembly (GO:0044458)9.42903633
7spermatid development (GO:0007286)9.35168123
8male meiosis (GO:0007140)8.76798330
9reproduction (GO:0000003)8.50628642
10synaptonemal complex organization (GO:0070193)8.38128555
11cilium movement (GO:0003341)8.37718059
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.20703282
13regulation of cilium movement (GO:0003352)8.11371443
14synaptonemal complex assembly (GO:0007130)8.00153872
15single fertilization (GO:0007338)7.08988819
16sperm capacitation (GO:0048240)6.60171438
17negative regulation of inclusion body assembly (GO:0090084)6.57326827
18DNA methylation involved in gamete generation (GO:0043046)6.50778394
19fertilization (GO:0009566)6.27781449
20spermatogenesis (GO:0007283)6.21576819
21male meiosis I (GO:0007141)6.20681334
22male gamete generation (GO:0048232)6.19330086
23regulation of vitamin D biosynthetic process (GO:0060556)5.93817542
24gamete generation (GO:0007276)5.68919901
25organic cation transport (GO:0015695)5.55978832
26chromosome organization involved in meiosis (GO:0070192)5.55354229
27ventricular system development (GO:0021591)5.53709249
28germ cell development (GO:0007281)5.42973718
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.42924081
30seminiferous tubule development (GO:0072520)5.41445207
31regulation of inclusion body assembly (GO:0090083)5.34064531
32microtubule depolymerization (GO:0007019)5.32941395
33meiotic nuclear division (GO:0007126)5.18573079
34meiosis I (GO:0007127)5.03660940
35calcium ion-dependent exocytosis (GO:0017156)5.02499674
36regulation of microtubule-based movement (GO:0060632)4.81827469
37microtubule severing (GO:0051013)4.80190815
38cell recognition (GO:0008037)4.79709619
39regulation of cytokine secretion involved in immune response (GO:0002739)4.73359478
40meiotic cell cycle (GO:0051321)4.62922842
41left/right pattern formation (GO:0060972)4.60593534
42protein localization to cilium (GO:0061512)4.58554908
43NIK/NF-kappaB signaling (GO:0038061)4.49361707
44multicellular organismal reproductive process (GO:0048609)4.47613131
45regulation of vitamin metabolic process (GO:0030656)4.41349261
46rRNA methylation (GO:0031167)4.18472660
47negative regulation of interleukin-12 production (GO:0032695)4.17978982
48positive regulation of heat generation (GO:0031652)4.10580320
49regulation of interferon-alpha production (GO:0032647)4.09921686
50lipopolysaccharide-mediated signaling pathway (GO:0031663)4.05191908
51regulation of mononuclear cell migration (GO:0071675)4.03668307
52genitalia morphogenesis (GO:0035112)4.03049765
53regulation of chronic inflammatory response (GO:0002676)3.89251927
54protein polyglutamylation (GO:0018095)3.89031004
55positive regulation of chemokine biosynthetic process (GO:0045080)3.85971820
56monoubiquitinated protein deubiquitination (GO:0035520)3.85511361
57regulation of T-helper 1 cell differentiation (GO:0045625)3.80646494
58chromosome condensation (GO:0030261)3.78490255
59spermatid nucleus differentiation (GO:0007289)3.78285097
60DNA packaging (GO:0006323)3.77272737
61gene silencing by RNA (GO:0031047)3.76937611
62intraciliary transport (GO:0042073)3.64713362
63multicellular organismal development (GO:0007275)3.63705227
64chaperone-mediated protein complex assembly (GO:0051131)3.63001421
65negative regulation of organelle assembly (GO:1902116)3.60905638
66regulation of type I interferon-mediated signaling pathway (GO:0060338)3.55589227
67response to type I interferon (GO:0034340)3.53122430
68cellular response to type I interferon (GO:0071357)3.51995228
69type I interferon signaling pathway (GO:0060337)3.51995228
70carnitine transport (GO:0015879)3.50729960
71amino-acid betaine transport (GO:0015838)3.50729960
72carnitine transmembrane transport (GO:1902603)3.48833523
73rRNA modification (GO:0000154)3.46583137
74axoneme assembly (GO:0035082)3.46382524
75response to peptidoglycan (GO:0032494)3.44501764
76myeloid dendritic cell differentiation (GO:0043011)3.44447425
77glycerol ether metabolic process (GO:0006662)3.44220773
78macrophage activation involved in immune response (GO:0002281)3.41927684
79kynurenine metabolic process (GO:0070189)3.40705004
80T-helper 1 type immune response (GO:0042088)3.38922214
81meiotic cell cycle process (GO:1903046)3.38797253
82regulation of podosome assembly (GO:0071801)3.38275269
83microtubule-based movement (GO:0007018)3.32976109
84DNA synthesis involved in DNA repair (GO:0000731)3.31100721
85regulation of chemokine biosynthetic process (GO:0045073)3.31072382
86germinal center formation (GO:0002467)3.30729077
87histone H3-K9 demethylation (GO:0033169)3.30276315
88regulation of membrane protein ectodomain proteolysis (GO:0051043)3.28625785
89mature B cell differentiation involved in immune response (GO:0002313)3.28370591
90branching involved in labyrinthine layer morphogenesis (GO:0060670)3.24137506
91synapsis (GO:0007129)3.23394389
92regulation of spindle checkpoint (GO:0090231)3.22924941
93positive regulation of interferon-alpha production (GO:0032727)3.21590460
94regulation of centriole replication (GO:0046599)3.19994507
95regulation of immunoglobulin secretion (GO:0051023)3.18554629
96protein refolding (GO:0042026)3.16988114
97indole-containing compound catabolic process (GO:0042436)3.16985693
98indolalkylamine catabolic process (GO:0046218)3.16985693
99tryptophan catabolic process (GO:0006569)3.16985693
100ether metabolic process (GO:0018904)3.16978145
101regulation of NFAT protein import into nucleus (GO:0051532)3.15646892
102positive regulation of T-helper cell differentiation (GO:0045624)3.14545614
103regulation of fever generation (GO:0031620)3.13943940
104regulation of T-helper 2 cell differentiation (GO:0045628)3.12769816
105cellular response to virus (GO:0098586)3.11664230
106lactate metabolic process (GO:0006089)3.11215687
107positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.11050798
108cilium organization (GO:0044782)3.06787154
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06526918
110positive regulation of defense response to virus by host (GO:0002230)3.06290139
111regulation of meiosis I (GO:0060631)3.05607980
112positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.05589932
113nuclear pore complex assembly (GO:0051292)3.04838227
114cellular response to ATP (GO:0071318)3.03880936
115response to ATP (GO:0033198)3.03390630
116sequestering of actin monomers (GO:0042989)3.01791020
117T cell lineage commitment (GO:0002360)3.00993071
118polyol catabolic process (GO:0046174)2.99827832
119oligosaccharide catabolic process (GO:0009313)2.98743411
120positive regulation of protein kinase C signaling (GO:0090037)2.97788481
121CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.96598475
122nucleus organization (GO:0006997)2.96574436
123negative regulation of nitric oxide biosynthetic process (GO:0045019)2.96057399
124mitotic sister chromatid cohesion (GO:0007064)2.95373662
125mannose metabolic process (GO:0006013)2.94923832
126response to protozoan (GO:0001562)2.94856122
127positive regulation of type 2 immune response (GO:0002830)2.93609048
128response to acidic pH (GO:0010447)2.93173506
129regulation of T-helper cell differentiation (GO:0045622)2.92938228
130positive regulation of NF-kappaB import into nucleus (GO:0042346)2.90732959
131alditol metabolic process (GO:0019400)2.90461608
132cilium assembly (GO:0042384)2.89444436
133positive regulation of lymphocyte apoptotic process (GO:0070230)2.88346353
134membrane lipid catabolic process (GO:0046466)2.87510350
135cilium morphogenesis (GO:0060271)2.87471459
136sphingolipid catabolic process (GO:0030149)2.85565302
137regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84761990
138glycosphingolipid catabolic process (GO:0046479)2.84091248
139regulation of protein polyubiquitination (GO:1902914)2.83360152
140regulation of defense response to virus by host (GO:0050691)2.83295454
141protein K11-linked deubiquitination (GO:0035871)2.83041372
142cellular component assembly involved in morphogenesis (GO:0010927)2.82896410
143positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82639750
144positive regulation of gamma-delta T cell activation (GO:0046645)2.82260294
145positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.82186667
146negative regulation of type I interferon production (GO:0032480)2.80725497
147nucleoside diphosphate phosphorylation (GO:0006165)2.79828013
148peptidyl-glutamic acid modification (GO:0018200)2.79709893
149regulation of nitric oxide biosynthetic process (GO:0045428)2.78095430
150gene silencing (GO:0016458)2.77219335
151defense response to protozoan (GO:0042832)2.76942885
152interferon-gamma secretion (GO:0072643)2.76752896
153activation of MAPKKK activity (GO:0000185)2.73988879
154N-acetylneuraminate metabolic process (GO:0006054)2.73306818
155dendritic cell differentiation (GO:0097028)2.72012229
156positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71337668
157microtubule polymerization or depolymerization (GO:0031109)2.70717040
158regulation of NF-kappaB import into nucleus (GO:0042345)2.70683130
159glycolytic process (GO:0006096)2.69836492
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69786550
161negative regulation of cytokine production involved in immune response (GO:0002719)2.69489441
162negative regulation of tumor necrosis factor production (GO:0032720)2.68350657
163positive regulation of neurotransmitter secretion (GO:0001956)2.68216117
164positive regulation of nitric oxide biosynthetic process (GO:0045429)2.66598263
165immunoglobulin mediated immune response (GO:0016064)2.65983773
166cellular response to lipopolysaccharide (GO:0071222)2.65568721
167amino sugar catabolic process (GO:0046348)2.65346629
168negative regulation of alcohol biosynthetic process (GO:1902931)2.65299537
169single strand break repair (GO:0000012)2.64295744
170RNA localization (GO:0006403)2.63535758
171negative regulation of DNA repair (GO:0045738)2.56016702
172centriole assembly (GO:0098534)2.52707835
173regulation of cilium assembly (GO:1902017)2.52467438
174glycerol metabolic process (GO:0006071)2.52110751
175cilium or flagellum-dependent cell motility (GO:0001539)13.7590076
176fusion of sperm to egg plasma membrane (GO:0007342)12.7681060
177sperm motility (GO:0030317)12.4983962
178acrosome reaction (GO:0007340)11.0989189
179sperm-egg recognition (GO:0035036)11.0135450
180acrosome assembly (GO:0001675)10.8421926
181axonemal dynein complex assembly (GO:0070286)10.6073543
182binding of sperm to zona pellucida (GO:0007339)10.2963211
183piRNA metabolic process (GO:0034587)10.2634845
184multicellular organism reproduction (GO:0032504)10.2604733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01992177
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.74034141
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.31615223
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.43140033
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.21603523
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.89224574
7VDR_21846776_ChIP-Seq_THP-1_Human2.87521173
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.60687462
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48222544
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45935288
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45651779
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38446206
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33820487
14LXR_22292898_ChIP-Seq_THP-1_Human2.29806480
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.26623380
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22954250
17MYC_22102868_ChIP-Seq_BL_Human2.22475334
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17017168
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.13752555
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.11249294
21MAF_26560356_Chip-Seq_TH2_Human2.10845326
22ZNF274_21170338_ChIP-Seq_K562_Hela2.10215583
23BCL6_27268052_Chip-Seq_Bcells_Human2.05898145
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.05585585
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05119961
26BCOR_27268052_Chip-Seq_Bcells_Human2.01559322
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00445074
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1362440
29MAF_26560356_Chip-Seq_TH1_Human1.98258137
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97504756
31SMC4_20622854_ChIP-Seq_HELA_Human1.96385284
32SPI1_23127762_ChIP-Seq_K562_Human1.94132049
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93187241
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.92739585
35VDR_22108803_ChIP-Seq_LS180_Human1.92091104
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.91995254
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91076920
38P68_20966046_ChIP-Seq_HELA_Human1.84963486
39E2F7_22180533_ChIP-Seq_HELA_Human1.83947604
40VDR_24763502_ChIP-Seq_THP-1_Human1.83175363
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82945640
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82194459
43SCL_19346495_ChIP-Seq_HPC-7_Human1.80658787
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80327131
45* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78898021
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78702016
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77044235
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.75359068
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73956132
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72783542
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71452994
52TCF7_22412390_ChIP-Seq_EML_Mouse1.60651761
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59304080
54FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59213701
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.58338774
56TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58007468
57KDM2B_26808549_Chip-Seq_DND41_Human1.57085784
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.56478875
59STAT1_17558387_ChIP-Seq_HELA_Human1.54395676
60* UTX_26944678_Chip-Seq_JUKART_Human1.51762792
61E2F1_20622854_ChIP-Seq_HELA_Human1.50383300
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.49648763
63PHF8_20622854_ChIP-Seq_HELA_Human1.47814610
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44723401
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44026279
66NCOR1_26117541_ChIP-Seq_K562_Human1.41757555
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41128180
68CBP_20019798_ChIP-Seq_JUKART_Human1.41128180
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41045052
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39211649
71REST_21632747_ChIP-Seq_MESCs_Mouse1.39209595
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38630081
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37209460
74GATA1_22025678_ChIP-Seq_K562_Human1.36627207
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35212276
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34901796
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34607197
78SOX2_22085726_ChIP-Seq_NPCs_Mouse1.33543785
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.32572844
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.31815266
81* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31354935
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30474603
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29451270
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29088391
85KDM2B_26808549_Chip-Seq_REH_Human1.28946213
86SA1_27219007_Chip-Seq_Bcells_Human1.28387060
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.28021371
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.27952310
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.26767257
90KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26751461
91SPI1_23547873_ChIP-Seq_NB4_Human1.25068516
92RACK7_27058665_Chip-Seq_MCF-7_Human1.24395564
93GATA1_19941826_ChIP-Seq_K562_Human1.23686652
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22451875
95* P300_27268052_Chip-Seq_Bcells_Human1.21967235
96MYB_26560356_Chip-Seq_TH1_Human1.21366343
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20430035
98LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19981552
99STAT1_20625510_ChIP-Seq_HELA_Human1.19957438
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19693036
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19078077
102* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18793320
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17880276
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17400828
105P53_21459846_ChIP-Seq_SAOS-2_Human1.17049877
106VDR_24787735_ChIP-Seq_THP-1_Human1.17043952
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15483987
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.14487618
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.14154682
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14123500
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13637951
112MYB_26560356_Chip-Seq_TH2_Human1.13433073
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12525208
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11721123
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11634742
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11634742
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11512489
118TP63_22573176_ChIP-Seq_HFKS_Human1.10997466
119CTCF_21964334_Chip-Seq_Bcells_Human1.10527862
120RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10500642
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10371720
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09202670
123CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09031062
124GATA1_19941827_ChIP-Seq_MEL_Mouse1.07295214
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07260418
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.06766891
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06655924
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06299281
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06174056
130RAC3_21632823_ChIP-Seq_H3396_Human1.05824327
131* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04976716
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.04932209
133GATA3_21867929_ChIP-Seq_TH1_Mouse1.04908777
134GF1_26923725_Chip-Seq_HPCs_Mouse1.04784104
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04396451
136* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04168740
137RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03899043
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.03885206
139UBF1/2_26484160_Chip-Seq_HMECs_Human1.03442243
140CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02384998
141CTCF_26484167_Chip-Seq_Bcells_Mouse1.01667150
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00713408
143CRX_20693478_ChIP-Seq_RETINA_Mouse1.00685802
144MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00132092
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00067975
146CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00063039
147RUNX_20019798_ChIP-Seq_JUKART_Human0.98849056
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.98322991
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.97327403
150SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96334045
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96099634
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.95540623
153YY1_22570637_ChIP-Seq_MALME-3M_Human0.95407577
154ERG_20517297_ChIP-Seq_VCAP_Human0.95296383
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95138078
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95000218
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94806864
158GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94795813
159CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94455946
160TFEB_21752829_ChIP-Seq_HELA_Human0.94437313
161ZNF263_19887448_ChIP-Seq_K562_Human0.94415695
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94377615
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94261107
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93662034
165SPI1_26923725_Chip-Seq_HPCs_Mouse0.92006241
166OCT4_18555785_Chip-Seq_ESCs_Mouse0.91883720
167SOX2_21211035_ChIP-Seq_LN229_Human0.91099960
168ESET_19884257_ChIP-Seq_ESCs_Mouse0.89313716
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89008956
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88726282
171OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88484031
172CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87878022
173RARA_24833708_ChIP-Seq_LIVER_Mouse0.87663797
174SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87571549
175P53_22387025_ChIP-Seq_ESCs_Mouse0.87502296
176RNF2_27304074_Chip-Seq_NSC_Mouse0.87388515
177RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87034163
178PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86732587
179EZH2_27294783_Chip-Seq_NPCs_Mouse0.86518934
180ELF1_20517297_ChIP-Seq_JURKAT_Human0.86365426
181EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85742675
182EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85589220
183PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84919953
184CTCF_20526341_ChIP-Seq_ESCs_Human0.83993131
185KLF4_18555785_Chip-Seq_ESCs_Mouse0.83779062
186SMAD4_21741376_ChIP-Seq_EPCs_Human0.83238296
187FLI1_21867929_ChIP-Seq_CD8_Mouse0.83228164
188LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82928444
189P300_18555785_Chip-Seq_ESCs_Mouse0.82542673
190GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81970169
191TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81879275
192RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81065164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.97207159
2MP0001929_abnormal_gametogenesis5.50108782
3MP0008877_abnormal_DNA_methylation5.05352427
4MP0003303_peritoneal_inflammation5.02256022
5MP0002210_abnormal_sex_determination3.70910972
6MP0005058_abnormal_lysosome_morphology3.57705198
7MP0004510_myositis3.42694486
8MP0002161_abnormal_fertility/fecundity3.23570794
9MP0005451_abnormal_body_composition3.12811840
10MP0001145_abnormal_male_reproductive3.12661020
11MP0002653_abnormal_ependyma_morphology2.80671920
12MP0002254_reproductive_system_inflammat2.77992944
13MP0002148_abnormal_hypersensitivity_rea2.74487219
14MP0000653_abnormal_sex_gland2.70792835
15MP0009785_altered_susceptibility_to2.64355380
16MP0001835_abnormal_antigen_presentation2.51845633
17MP0003436_decreased_susceptibility_to2.32886121
18MP0006082_CNS_inflammation2.29069592
19MP0001790_abnormal_immune_system2.27280296
20MP0005387_immune_system_phenotype2.27280296
21MP0002160_abnormal_reproductive_system2.26745995
22MP0009840_abnormal_foam_cell2.26662548
23MP0002139_abnormal_hepatobiliary_system2.17513554
24MP0005000_abnormal_immune_tolerance2.15374397
25MP0005623_abnormal_meninges_morphology2.06508018
26MP0005670_abnormal_white_adipose2.04433272
27MP0006054_spinal_hemorrhage2.03312432
28MP0005310_abnormal_salivary_gland2.01017656
29MP0005410_abnormal_fertilization15.6816654
30MP0008004_abnormal_stomach_pH1.95940392
31MP0005671_abnormal_response_to1.92990731
32MP0009764_decreased_sensitivity_to1.90679601
33MP0005025_abnormal_response_to1.90207592
34MP0002419_abnormal_innate_immunity1.80489539
35MP0003646_muscle_fatigue1.79104596
36MP0003806_abnormal_nucleotide_metabolis1.76249877
37MP0001800_abnormal_humoral_immune1.75558813
38MP0002723_abnormal_immune_serum1.74503035
39MP0002452_abnormal_antigen_presenting1.69035186
40MP0005167_abnormal_blood-brain_barrier1.58462383
41MP0002332_abnormal_exercise_endurance1.54754506
42MP0004947_skin_inflammation1.51356638
43MP0003453_abnormal_keratinocyte_physiol1.51101878
44MP0003724_increased_susceptibility_to1.45007767
45MP0003172_abnormal_lysosome_physiology1.44963453
46MP0002405_respiratory_system_inflammati1.40168583
47MP0008469_abnormal_protein_level1.35625702
48MP0008057_abnormal_DNA_replication1.33248421
49MP0001873_stomach_inflammation1.32191254
50MP0000343_altered_response_to1.31545700
51MP0001845_abnormal_inflammatory_respons1.30483652
52MP0003075_altered_response_to1.28346072
53MP0000678_abnormal_parathyroid_gland1.25760818
54MP0002420_abnormal_adaptive_immunity1.25674985
55MP0001819_abnormal_immune_cell1.25174840
56MP0003300_gastrointestinal_ulcer1.24921759
57MP0002282_abnormal_trachea_morphology1.22904171
58MP0009046_muscle_twitch1.20682219
59MP0004233_abnormal_muscle_weight1.18698711
60MP0000371_diluted_coat_color1.16656907
61MP0005076_abnormal_cell_differentiation1.15731271
62MP0002138_abnormal_hepatobiliary_system1.15588964
63MP0005389_reproductive_system_phenotype1.15194881
64MP0003448_altered_tumor_morphology1.15039044
65MP0001984_abnormal_olfaction1.11380539
66MP0001853_heart_inflammation1.09086383
67MP0001533_abnormal_skeleton_physiology1.08677045
68MP0009697_abnormal_copulation1.08573282
69MP0005647_abnormal_sex_gland1.04787025
70MP0000716_abnormal_immune_system1.04087883
71MP0009333_abnormal_splenocyte_physiolog1.03658651
72MP0010155_abnormal_intestine_physiology1.01765981
73MP0008995_early_reproductive_senescence1.00741128
74MP0008058_abnormal_DNA_repair0.99142967
75MP0001765_abnormal_ion_homeostasis0.96789352
76MP0002998_abnormal_bone_remodeling0.96389738
77MP0003656_abnormal_erythrocyte_physiolo0.95669298
78MP0003091_abnormal_cell_migration0.94815315
79MP0002398_abnormal_bone_marrow0.93110733
80MP0010094_abnormal_chromosome_stability0.92597755
81MP0000685_abnormal_immune_system0.91452623
82MP0003195_calcinosis0.88736670
83MP0002429_abnormal_blood_cell0.86124985
84MP0002693_abnormal_pancreas_physiology0.83439916
85MP0000689_abnormal_spleen_morphology0.83439526
86MP0005266_abnormal_metabolism0.81128123
87MP0001986_abnormal_taste_sensitivity0.81072613
88MP0003011_delayed_dark_adaptation0.80286316
89MP0001501_abnormal_sleep_pattern0.79875804
90MP0003763_abnormal_thymus_physiology0.79621732
91MP0002837_dystrophic_cardiac_calcinosis0.78812306
92MP0002722_abnormal_immune_system0.77582200
93MP0009278_abnormal_bone_marrow0.71253892
94MP0008007_abnormal_cellular_replicative0.70233694
95MP0003115_abnormal_respiratory_system0.69788452
96MP0001545_abnormal_hematopoietic_system0.69614644
97MP0005397_hematopoietic_system_phenotyp0.69614644
98MP0005535_abnormal_body_temperature0.69361919
99MP0003786_premature_aging0.67807979
100MP0005166_decreased_susceptibility_to0.67330908
101MP0000569_abnormal_digit_pigmentation0.66899910
102MP0000609_abnormal_liver_physiology0.65429532
103MP0003878_abnormal_ear_physiology0.65090865
104MP0005377_hearing/vestibular/ear_phenot0.65090865
105MP0000358_abnormal_cell_content/0.64674424
106MP0003690_abnormal_glial_cell0.64415463
107MP0003950_abnormal_plasma_membrane0.64320533
108MP0003183_abnormal_peptide_metabolism0.63707120
109MP0003329_amyloid_beta_deposits0.55184518
110MP0003111_abnormal_nucleus_morphology0.55019475
111MP0002234_abnormal_pharynx_morphology0.51506904
112MP0010307_abnormal_tumor_latency0.50806365
113MP0003699_abnormal_female_reproductive0.50136117
114MP0004808_abnormal_hematopoietic_stem0.47425328
115MP0001727_abnormal_embryo_implantation0.46922238
116MP0004134_abnormal_chest_morphology0.46210558
117MP0005636_abnormal_mineral_homeostasis0.44736121
118MP0002928_abnormal_bile_duct0.44623001
119MP0005666_abnormal_adipose_tissue0.44018095
120MP0003787_abnormal_imprinting0.41357970
121MP0004036_abnormal_muscle_relaxation0.40412036
122MP0008961_abnormal_basal_metabolism0.40051231
123MP0001661_extended_life_span0.39412538
124MP0001730_embryonic_growth_arrest0.38118643
125MP0004811_abnormal_neuron_physiology0.37561710
126MP0003879_abnormal_hair_cell0.37331937
127MP0005551_abnormal_eye_electrophysiolog0.37200033
128MP0005253_abnormal_eye_physiology0.36343176
129MP0000751_myopathy0.36124456
130MP0001119_abnormal_female_reproductive0.35616970
131MP0001293_anophthalmia0.34398326
132MP0004270_analgesia0.33755230
133MP0001324_abnormal_eye_pigmentation0.33737397
134MP0003861_abnormal_nervous_system0.32522923
135MP0002152_abnormal_brain_morphology0.31824274
136MP0005391_vision/eye_phenotype0.31351450
137MP0002269_muscular_atrophy0.30140385
138MP0003045_fibrosis0.29959574
139MP0006036_abnormal_mitochondrial_physio0.28774277
140MP0005423_abnormal_somatic_nervous0.28066112
141MP0000534_abnormal_ureter_morphology0.25873928
142MP0009115_abnormal_fat_cell0.25280796
143MP0002102_abnormal_ear_morphology0.25222251
144MP0002108_abnormal_muscle_morphology0.25088629
145MP0003633_abnormal_nervous_system0.25006332
146MP0002971_abnormal_brown_adipose0.24629578
147MP0000313_abnormal_cell_death0.24056328
148MP0003942_abnormal_urinary_system0.23540515
149MP0002084_abnormal_developmental_patter0.22872227
150MP0003077_abnormal_cell_cycle0.22633349
151MP0001764_abnormal_homeostasis0.22605143
152MP0002572_abnormal_emotion/affect_behav0.22548535
153MP0004019_abnormal_vitamin_homeostasis0.21411607
154MP0002736_abnormal_nociception_after0.20883697
155MP0003936_abnormal_reproductive_system0.20243018
156MP0006035_abnormal_mitochondrial_morpho0.20108413
157MP0008569_lethality_at_weaning0.19904092
158MP0003631_nervous_system_phenotype0.19648742
159MP0001440_abnormal_grooming_behavior0.19402518
160MP0000604_amyloidosis0.19317450
161MP0002092_abnormal_eye_morphology0.18996324
162MP0002169_no_abnormal_phenotype0.18984127
163MP0002295_abnormal_pulmonary_circulatio0.18950480
164MP0002873_normal_phenotype0.18712656
165MP0002796_impaired_skin_barrier0.18363620
166MP0002229_neurodegeneration0.17200571
167MP0004133_heterotaxia0.17156349
168MP0003948_abnormal_gas_homeostasis0.16906529
169MP0003635_abnormal_synaptic_transmissio0.16754838
170MP0001851_eye_inflammation0.16431091
171MP0004043_abnormal_pH_regulation0.15031603
172MP0002063_abnormal_learning/memory/cond0.14911986

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.11057042
2Abnormal respiratory epithelium morphology (HP:0012253)8.68754243
3Abnormal respiratory motile cilium morphology (HP:0005938)8.68754243
4Rhinitis (HP:0012384)7.82608868
5Chronic bronchitis (HP:0004469)7.16852459
6Abnormal ciliary motility (HP:0012262)7.09064895
7Infertility (HP:0000789)6.59685654
8Nasal polyposis (HP:0100582)6.44700601
9Abnormality of liposaccharide metabolism (HP:0010968)6.07248364
10Abnormality of glycosphingolipid metabolism (HP:0004343)6.07248364
11Abnormality of glycolipid metabolism (HP:0010969)6.07248364
12Abnormality of the nasal mucosa (HP:0000433)5.29335139
13Nephronophthisis (HP:0000090)4.73688881
14Loss of speech (HP:0002371)4.62387317
15Bronchiectasis (HP:0002110)4.57485804
16Bronchitis (HP:0012387)4.46603689
17Disinhibition (HP:0000734)3.92129452
18Autoimmune thrombocytopenia (HP:0001973)3.81386836
19Abnormality of the lower motor neuron (HP:0002366)3.75295743
20Increased cerebral lipofuscin (HP:0011813)3.65031862
21Abnormality of the renal medulla (HP:0100957)3.58912793
22Male infertility (HP:0003251)3.56900168
23Severe visual impairment (HP:0001141)3.41860494
24Recurrent otitis media (HP:0000403)3.32015620
25Gonadotropin excess (HP:0000837)3.17869552
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.10361341
27Recurrent sinusitis (HP:0011108)3.08727601
28Abnormal spermatogenesis (HP:0008669)3.06879857
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.06875745
30Tubulointerstitial nephritis (HP:0001970)3.04652015
31Abnormality of macrophages (HP:0004311)3.01215601
32Dysostosis multiplex (HP:0000943)3.00148540
33Stomatitis (HP:0010280)2.99116187
34Personality changes (HP:0000751)2.96900464
35Abnormality of the fingertips (HP:0001211)2.95572238
36Retrobulbar optic neuritis (HP:0100654)2.95054191
37Optic neuritis (HP:0100653)2.95054191
38Colitis (HP:0002583)2.92556363
39Amyotrophic lateral sclerosis (HP:0007354)2.91322973
40Tubular atrophy (HP:0000092)2.81927719
41Retinal atrophy (HP:0001105)2.81154517
42Orchitis (HP:0100796)2.80380041
43Recurrent abscess formation (HP:0002722)2.77023946
44Abnormality of polysaccharide metabolism (HP:0011012)2.76965027
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.76965027
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.76965027
47Nuclear cataract (HP:0100018)2.75281463
48Increased serum ferritin (HP:0003281)2.70113058
49Progressive external ophthalmoplegia (HP:0000590)2.68790180
50Abnormality of midbrain morphology (HP:0002418)2.68438881
51Molar tooth sign on MRI (HP:0002419)2.68438881
52Systemic lupus erythematosus (HP:0002725)2.68088413
53Recurrent bronchitis (HP:0002837)2.66437841
54Recurrent bacterial skin infections (HP:0005406)2.63038902
55Combined immunodeficiency (HP:0005387)2.60212680
56Tubulointerstitial abnormality (HP:0001969)2.59839713
57Asymmetric septal hypertrophy (HP:0001670)2.54395963
58Vacuolated lymphocytes (HP:0001922)2.52862201
59Impulsivity (HP:0100710)2.50640881
60Mucopolysacchariduria (HP:0008155)2.49857965
61Urinary glycosaminoglycan excretion (HP:0003541)2.49857965
62Recurrent viral infections (HP:0004429)2.44334843
63Inappropriate behavior (HP:0000719)2.44222720
64Generalized aminoaciduria (HP:0002909)2.41667698
65Aplasia/Hypoplasia of the thymus (HP:0010515)2.40627235
66Fibular hypoplasia (HP:0003038)2.40133736
67Thin bony cortex (HP:0002753)2.40043858
68Medial flaring of the eyebrow (HP:0010747)2.38890955
69Abnormality of the parathyroid morphology (HP:0011766)2.38391971
70IgA deficiency (HP:0002720)2.35518617
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35399981
72Ragged-red muscle fibers (HP:0003200)2.34015499
73Impaired proprioception (HP:0010831)2.32665807
74Mutism (HP:0002300)2.31726692
75Azoospermia (HP:0000027)2.30575154
76Myositis (HP:0100614)2.30463160
77Malnutrition (HP:0004395)2.23454396
78Poikiloderma (HP:0001029)2.21489435
79Enlarged epiphyses (HP:0010580)2.19862950
80Basal ganglia calcification (HP:0002135)2.19625971
81Thoracic kyphosis (HP:0002942)2.19116128
82Postaxial foot polydactyly (HP:0001830)2.16030086
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15773189
84Apathy (HP:0000741)2.15399337
85Microvesicular hepatic steatosis (HP:0001414)2.12751545
86Stage 5 chronic kidney disease (HP:0003774)2.12243990
87Agnosia (HP:0010524)2.11978003
88Obstructive lung disease (HP:0006536)2.11700094
89Chronic obstructive pulmonary disease (HP:0006510)2.11700094
90Neuronal loss in central nervous system (HP:0002529)2.09927029
91Insulin-resistant diabetes mellitus (HP:0000831)2.08692975
92Tubulointerstitial fibrosis (HP:0005576)2.08003350
93Symptomatic seizures (HP:0011145)2.06483585
94Mediastinal lymphadenopathy (HP:0100721)2.05771425
95Dementia (HP:0000726)2.05211913
96Abnormality of the thymus (HP:0000777)2.05079603
97Upper motor neuron abnormality (HP:0002127)2.04829350
98Bony spicule pigmentary retinopathy (HP:0007737)2.04557660
99Polydipsia (HP:0001959)2.04412474
100Abnormal drinking behavior (HP:0030082)2.04412474
101Mesangial abnormality (HP:0001966)2.03295466
102Flat occiput (HP:0005469)2.03209056
103Abnormality of the basal ganglia (HP:0002134)2.01838843
104Cholecystitis (HP:0001082)2.01578165
105Abnormal gallbladder physiology (HP:0012438)2.01578165
106Abnormality of transition element cation homeostasis (HP:0011030)2.01242855
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2664736
108Dynein arm defect of respiratory motile cilia (HP:0012255)12.4629322
109Absent/shortened dynein arms (HP:0200106)12.4629322
110Glomerulonephritis (HP:0000099)1.98519840
111Polyneuropathy (HP:0001271)1.96504298
112Abnormal large intestine physiology (HP:0012700)1.94790294
113Short ribs (HP:0000773)1.94658120
114Congenital hepatic fibrosis (HP:0002612)1.92644535
115Spastic tetraparesis (HP:0001285)1.91000965
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89110634
117Absent epiphyses (HP:0010577)1.89110634
118Abnormality of the columella (HP:0009929)1.88963429
119Hyperthyroidism (HP:0000836)1.87042466
120Hypertensive crisis (HP:0100735)1.86771801
121Absent frontal sinuses (HP:0002688)1.85867980
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85134347
123Degeneration of anterior horn cells (HP:0002398)1.84972450
124Abnormality of the anterior horn cell (HP:0006802)1.84972450
125Abnormality of the renal cortex (HP:0011035)1.84079291
126Increased IgM level (HP:0003496)1.83637309
127Heterotopia (HP:0002282)1.83191243
128Abnormality of iron homeostasis (HP:0011031)1.82647225
129Abnormality of the dental root (HP:0006486)1.82409740
130Taurodontia (HP:0000679)1.82409740
131Abnormality of permanent molar morphology (HP:0011071)1.82409740
132Oculomotor apraxia (HP:0000657)1.82092164
133Resting tremor (HP:0002322)1.81364622
134Protuberant abdomen (HP:0001538)1.81248174
135Intestinal fistula (HP:0100819)1.80810597
136Attenuation of retinal blood vessels (HP:0007843)1.80722422
137Diminished motivation (HP:0000745)1.80259208
138Metaphyseal irregularity (HP:0003025)1.79746787
139Abnormality of dentin (HP:0010299)1.79476767
140J-shaped sella turcica (HP:0002680)1.79370110
141Bowel incontinence (HP:0002607)1.78555070
142Cerebral inclusion bodies (HP:0100314)1.77427997
143Renal dysplasia (HP:0000110)1.75572922
144Severe combined immunodeficiency (HP:0004430)1.73311882
145Ectropion (HP:0000656)1.72328314
146Progressive muscle weakness (HP:0003323)1.71105917
147Thoracolumbar scoliosis (HP:0002944)1.70735144
148Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70640381
149Abnormality of lateral ventricle (HP:0030047)1.69922922
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69866801
151Abnormality of molar (HP:0011077)1.69346126
152Abnormality of molar morphology (HP:0011070)1.69346126
153Inflammation of the large intestine (HP:0002037)1.68541062
154Flat capital femoral epiphysis (HP:0003370)1.68263925
155Anhidrosis (HP:0000970)1.67480608
156Prolonged neonatal jaundice (HP:0006579)1.67381436
157Abnormality of renal excretion (HP:0011036)1.66549562
158Abnormality of the dental pulp (HP:0006479)1.64990147
159Facial cleft (HP:0002006)1.64940313
160Bell-shaped thorax (HP:0001591)1.63375136
161Postaxial hand polydactyly (HP:0001162)1.62283291
162Microglossia (HP:0000171)1.60744494
163Short thorax (HP:0010306)1.57934879
164Broad distal phalanx of finger (HP:0009836)1.55676030
165Dyschromatopsia (HP:0007641)1.54260653
166Supernumerary spleens (HP:0009799)1.52359916
167Choroideremia (HP:0001139)1.49156507
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.49120985
169Short femoral neck (HP:0100864)1.44623289
170Decreased motor nerve conduction velocity (HP:0003431)1.44206965
171Deformed sella turcica (HP:0002681)1.43949416
172Abnormality of ocular smooth pursuit (HP:0000617)1.42668807
173Chronic sinusitis (HP:0011109)1.40844644
174Median cleft lip (HP:0000161)1.38505192
175Nephropathy (HP:0000112)1.37065899
176Abnormal urine output (HP:0012590)1.36508327
177Cystic liver disease (HP:0006706)1.28873359
178Bile duct proliferation (HP:0001408)1.27959130
179Abnormal biliary tract physiology (HP:0012439)1.27959130
180Pachygyria (HP:0001302)1.27757060
181Gaze-evoked nystagmus (HP:0000640)1.27167088
182Conjunctival telangiectasia (HP:0000524)1.26647882
183Neurofibrillary tangles (HP:0002185)1.26455917
184Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.25928655
185Polyuria (HP:0000103)1.25424247
186Aplasia/Hypoplasia of the lens (HP:0008063)1.23592271
187Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.23529060
188Cerebellar dysplasia (HP:0007033)1.22812110
189Aplasia/Hypoplasia of the tongue (HP:0010295)1.22771494
190Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.22325956
191Hemiparesis (HP:0001269)1.21953864
192Breast carcinoma (HP:0003002)1.20167091
19311 pairs of ribs (HP:0000878)1.20083207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.42977876
2PDK48.42977876
3TESK15.89048813
4PDK25.52956174
5IRAK35.28602820
6PRKD34.62830285
7NME24.60553647
8DDR23.97017132
9ICK3.82477247
10TAOK23.24880674
11PTK2B2.69975072
12MAP3K142.48940964
13PNCK2.38448537
14WNK42.37635310
15BLK2.35926916
16GRK72.22246753
17MATK2.19877517
18STK392.18507261
19PIM22.12444995
20ACVR1B2.07858749
21NEK21.98946463
22ERN11.95903466
23IKBKB1.88954990
24TBK11.84801372
25STK381.82524201
26TRIB31.81962603
27MAP3K111.78732909
28CHUK1.59915479
29CDC42BPA1.56810568
30IKBKE1.55923323
31MAP2K31.53749439
32PRPF4B1.53411718
33TLK11.53268766
34FGR1.50272338
35RIPK11.47456176
36MAP3K31.45040770
37ADRBK21.41090953
38MAP4K11.31109629
39TAOK31.30952759
40LATS21.25020650
41INSRR1.15542222
42WNK11.11693143
43TYK21.11493879
44DYRK1B1.06056533
45MAPK151.04975713
46IRAK41.00023608
47TYRO30.99180395
48HIPK20.97897554
49JAK30.97610695
50CDK40.96860670
51PDK10.96258973
52MELK0.93136309
53STK30.92185384
54CCNB10.92025417
55MAPK110.88721100
56MAP3K50.86400060
57PASK0.84400271
58BMPR20.77465682
59MAP3K10.77236463
60ERBB40.75149196
61PIM10.75134364
62CDC70.72776833
63PINK10.72191293
64SMG10.69391289
65TTK0.69287074
66BMX0.68605930
67CAMK1G0.64334924
68DYRK30.64254060
69MAP3K130.62573835
70PKN20.61507316
71SIK20.61343084
72MOS0.58497082
73LYN0.57644019
74ZAK0.56241551
75IRAK10.55135363
76MST1R0.55040641
77PKN10.54916205
78EEF2K0.53494303
79BTK0.53352827
80TGFBR20.52489808
81CAMK1D0.51207481
82SYK0.49994033
83JAK10.48888277
84SIK10.46680406
85CHEK20.46094245
86TESK20.45639516
87MAP3K80.45047437
88NEK90.44714818
89PDPK10.43672378
90CHEK10.43450519
91ATR0.43318078
92NTRK20.43133912
93PDGFRA0.41739100
94RPS6KA50.40496666
95KIT0.40096088
96LCK0.39801168
97PBK0.38120169
98STK38L0.37753307
99WEE10.36495148
100PRKAA20.36128915
101LMTK20.35964952
102MTOR0.34417215
103ATM0.33960759
104BMPR1B0.33029941
105CDK60.33003881
106CAMKK10.32023227
107ABL20.31490189
108MAPK10.31414203
109PAK20.31383037
110PRKCG0.28342030
111PAK10.28119463
112RIPK40.26733634
113MAP2K60.26266790
114TXK0.26026874
115MUSK0.25723425
116MARK20.25619495
117PRKAA10.25508396
118RPS6KB10.21946161
119PAK60.21588345
120IRAK20.21563180
121NEK60.19164142
122MAP3K40.18586375
123PLK10.18429163
124PLK40.16204551
125STK110.10824479
126MAPKAPK50.10482431
127CDK120.10257471
128TAOK10.10133771
129FGFR20.08011866
130PRKCZ0.07803442
131WNK30.07751837
132PRKCQ0.07614005
133CDK150.06592757
134GSK3B0.05199126
135CSNK1D0.05034117
136CDK180.04927813
137PAK40.04375926
138CDK10.04066018
139CDK20.03945663
140MAPK80.03373151
141CDK11A0.03327799
142FRK0.02696427
143CAMK2A0.01936633
144PRKACG0.01774151
145RPS6KA10.01607868
146CSNK2A10.01572892
147PRKG10.01490343
148STK100.01475577
149CLK10.01310979
150CDK140.01168889
151PRKCB0.01007335
152MAP2K70.00961891
153RPS6KA30.00693751
154PRKDC0.00636017
155PDGFRB0.00554740
156PRKACB0.00240103
157BRAF-0.0287903
158PRKCA-0.0285979
159BRSK1-0.0260535
160EGFR-0.0258312
161MAPK10-0.0231690
162MARK3-0.0161566
163CSK-0.0145460
164MINK1-0.0121531
165ZAP70-0.0118496
166CSF1R-0.0061976
167MARK1-0.0042331
168PRKG2-0.0037574
169MAP3K10-0.0018576

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.42190590
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.97686277
3Pyruvate metabolism_Homo sapiens_hsa006203.94517935
4Fatty acid biosynthesis_Homo sapiens_hsa000613.45788549
5Other glycan degradation_Homo sapiens_hsa005113.27595692
6Glucagon signaling pathway_Homo sapiens_hsa049222.94569039
7Propanoate metabolism_Homo sapiens_hsa006402.90298606
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.89690434
9Dorso-ventral axis formation_Homo sapiens_hsa043202.87564481
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.83911474
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.81455552
12Basal transcription factors_Homo sapiens_hsa030222.60958683
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.56410564
14Lysosome_Homo sapiens_hsa041422.44907437
15Linoleic acid metabolism_Homo sapiens_hsa005912.43429071
16Osteoclast differentiation_Homo sapiens_hsa043802.41406811
17Selenocompound metabolism_Homo sapiens_hsa004502.41187915
18Fanconi anemia pathway_Homo sapiens_hsa034602.30455677
19TNF signaling pathway_Homo sapiens_hsa046682.28962567
20Rheumatoid arthritis_Homo sapiens_hsa053232.16524668
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.14930753
22Oocyte meiosis_Homo sapiens_hsa041142.12553775
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08060057
24Amphetamine addiction_Homo sapiens_hsa050312.05273806
25Allograft rejection_Homo sapiens_hsa053301.98514238
26Glycerolipid metabolism_Homo sapiens_hsa005611.98229428
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.95949072
28Influenza A_Homo sapiens_hsa051641.93657063
29Pentose phosphate pathway_Homo sapiens_hsa000301.91015072
30Malaria_Homo sapiens_hsa051441.85757365
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83128424
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76726531
33Herpes simplex infection_Homo sapiens_hsa051681.76130399
34Type II diabetes mellitus_Homo sapiens_hsa049301.74528441
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.71287914
36Leishmaniasis_Homo sapiens_hsa051401.70345713
37Huntingtons disease_Homo sapiens_hsa050161.62203479
38Pertussis_Homo sapiens_hsa051331.61644946
39Asthma_Homo sapiens_hsa053101.60732895
40Graft-versus-host disease_Homo sapiens_hsa053321.60349735
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.58561436
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55558407
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55126372
44Tuberculosis_Homo sapiens_hsa051521.55109463
45PPAR signaling pathway_Homo sapiens_hsa033201.54198261
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.53168104
47Renin secretion_Homo sapiens_hsa049241.49633931
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49016967
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47960054
50Homologous recombination_Homo sapiens_hsa034401.46149417
51Toxoplasmosis_Homo sapiens_hsa051451.42887204
52Staphylococcus aureus infection_Homo sapiens_hsa051501.41258750
53Autoimmune thyroid disease_Homo sapiens_hsa053201.40622084
54African trypanosomiasis_Homo sapiens_hsa051431.39464974
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38576658
56Type I diabetes mellitus_Homo sapiens_hsa049401.36476027
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.36457426
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.36291371
59mRNA surveillance pathway_Homo sapiens_hsa030151.32934713
60Cardiac muscle contraction_Homo sapiens_hsa042601.31793739
61Fructose and mannose metabolism_Homo sapiens_hsa000511.31784739
62Measles_Homo sapiens_hsa051621.30153433
63Long-term potentiation_Homo sapiens_hsa047201.28000524
64Acute myeloid leukemia_Homo sapiens_hsa052211.26456036
65Bladder cancer_Homo sapiens_hsa052191.26183255
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23902102
67RNA transport_Homo sapiens_hsa030131.19437121
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19346367
69Apoptosis_Homo sapiens_hsa042101.19214239
70Primary immunodeficiency_Homo sapiens_hsa053401.15120596
71Carbon metabolism_Homo sapiens_hsa012001.14897115
72Hepatitis C_Homo sapiens_hsa051601.13401956
73Epstein-Barr virus infection_Homo sapiens_hsa051691.12732823
74Antigen processing and presentation_Homo sapiens_hsa046121.11519096
75Glycosaminoglycan degradation_Homo sapiens_hsa005311.09516636
76Fat digestion and absorption_Homo sapiens_hsa049751.08275661
77Ether lipid metabolism_Homo sapiens_hsa005651.05558844
78Hepatitis B_Homo sapiens_hsa051611.04539717
79Salmonella infection_Homo sapiens_hsa051321.03901891
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02022853
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01411058
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00468422
83Estrogen signaling pathway_Homo sapiens_hsa049150.97778745
84Fatty acid metabolism_Homo sapiens_hsa012120.95776662
85Prolactin signaling pathway_Homo sapiens_hsa049170.95362043
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94274800
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93843641
88Sulfur relay system_Homo sapiens_hsa041220.92811752
89Prion diseases_Homo sapiens_hsa050200.91392379
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88559349
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87837711
92Mineral absorption_Homo sapiens_hsa049780.87709914
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87060983
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83780260
95Purine metabolism_Homo sapiens_hsa002300.83398810
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83311320
97Fatty acid degradation_Homo sapiens_hsa000710.82009055
98mTOR signaling pathway_Homo sapiens_hsa041500.81378275
99ABC transporters_Homo sapiens_hsa020100.78853567
100Calcium signaling pathway_Homo sapiens_hsa040200.78570533
101Hematopoietic cell lineage_Homo sapiens_hsa046400.77047644
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.76129698
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74838092
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73283399
105Viral myocarditis_Homo sapiens_hsa054160.72462120
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72429226
107VEGF signaling pathway_Homo sapiens_hsa043700.71543832
108Insulin secretion_Homo sapiens_hsa049110.70668192
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.68648166
110Hedgehog signaling pathway_Homo sapiens_hsa043400.65046639
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64316934
112HTLV-I infection_Homo sapiens_hsa051660.63594500
113Glutathione metabolism_Homo sapiens_hsa004800.63352035
114Insulin resistance_Homo sapiens_hsa049310.62829376
115Systemic lupus erythematosus_Homo sapiens_hsa053220.61624018
116Biosynthesis of amino acids_Homo sapiens_hsa012300.61219110
117Lysine degradation_Homo sapiens_hsa003100.60639135
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.60596904
119Chemokine signaling pathway_Homo sapiens_hsa040620.59720023
120Phagosome_Homo sapiens_hsa041450.59689773
121Collecting duct acid secretion_Homo sapiens_hsa049660.59461324
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59187552
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58671378
124AMPK signaling pathway_Homo sapiens_hsa041520.57760898
125Circadian entrainment_Homo sapiens_hsa047130.57712729
126Synaptic vesicle cycle_Homo sapiens_hsa047210.57218297
127Endocytosis_Homo sapiens_hsa041440.55878521
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55527930
129Inositol phosphate metabolism_Homo sapiens_hsa005620.55289441
130Notch signaling pathway_Homo sapiens_hsa043300.54122794
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52945151
132Thyroid hormone synthesis_Homo sapiens_hsa049180.52312864
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50494111
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.49994107
135Shigellosis_Homo sapiens_hsa051310.48342689
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46540194
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.45926020
138Arachidonic acid metabolism_Homo sapiens_hsa005900.45561837
139Alcoholism_Homo sapiens_hsa050340.44809122
140Taste transduction_Homo sapiens_hsa047420.44300025
141Small cell lung cancer_Homo sapiens_hsa052220.43950398
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43767759
143Salivary secretion_Homo sapiens_hsa049700.42643439
144Non-homologous end-joining_Homo sapiens_hsa034500.42315512
145Tryptophan metabolism_Homo sapiens_hsa003800.41876168
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41075901
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40603393
148Legionellosis_Homo sapiens_hsa051340.39973822
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39536252
150Bile secretion_Homo sapiens_hsa049760.38564172
151cAMP signaling pathway_Homo sapiens_hsa040240.37822246
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37229003
153Glutamatergic synapse_Homo sapiens_hsa047240.37035525
154Chemical carcinogenesis_Homo sapiens_hsa052040.36948255
155HIF-1 signaling pathway_Homo sapiens_hsa040660.36237042
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35157831
157Gastric acid secretion_Homo sapiens_hsa049710.35076926
158FoxO signaling pathway_Homo sapiens_hsa040680.34344900
159Cocaine addiction_Homo sapiens_hsa050300.33780946
160Pancreatic cancer_Homo sapiens_hsa052120.33491015
161B cell receptor signaling pathway_Homo sapiens_hsa046620.32656937
162Olfactory transduction_Homo sapiens_hsa047400.31511934
163Chronic myeloid leukemia_Homo sapiens_hsa052200.31504669
164Wnt signaling pathway_Homo sapiens_hsa043100.31195583
165Dopaminergic synapse_Homo sapiens_hsa047280.31145691
166Pyrimidine metabolism_Homo sapiens_hsa002400.30137175
167Viral carcinogenesis_Homo sapiens_hsa052030.29758343
168Oxytocin signaling pathway_Homo sapiens_hsa049210.28939218
169Pancreatic secretion_Homo sapiens_hsa049720.28856043
170Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26646977
171N-Glycan biosynthesis_Homo sapiens_hsa005100.26256714
172RNA degradation_Homo sapiens_hsa030180.25238870
173Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24079120
174Protein digestion and absorption_Homo sapiens_hsa049740.22301302
175Sphingolipid metabolism_Homo sapiens_hsa006000.21519691
176T cell receptor signaling pathway_Homo sapiens_hsa046600.20345248
177Metabolic pathways_Homo sapiens_hsa011000.19853471

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