FAM187A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)8.95303599
2cilium or flagellum-dependent cell motility (GO:0001539)8.94335349
3cilium movement (GO:0003341)8.32765439
4acrosome reaction (GO:0007340)8.29326793
5sperm motility (GO:0030317)8.09904443
6epithelial cilium movement (GO:0003351)7.75691137
7piRNA metabolic process (GO:0034587)7.05523138
8multicellular organism reproduction (GO:0032504)7.04107730
9ventricular system development (GO:0021591)6.55619199
10fusion of sperm to egg plasma membrane (GO:0007342)6.27795977
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.07486737
12sperm-egg recognition (GO:0035036)5.93611521
13spermatid development (GO:0007286)5.90655065
14reproduction (GO:0000003)5.82753054
15regulation of cilium movement (GO:0003352)5.81303212
16microtubule severing (GO:0051013)5.79856071
17primary alcohol catabolic process (GO:0034310)5.57096372
18sperm capacitation (GO:0048240)5.41995647
19male meiosis (GO:0007140)5.27025494
20cell-cell recognition (GO:0009988)5.24462961
21acrosome assembly (GO:0001675)5.00331501
22microtubule depolymerization (GO:0007019)4.96976246
23plasma membrane fusion (GO:0045026)4.87995064
24binding of sperm to zona pellucida (GO:0007339)4.82329372
25cell wall macromolecule metabolic process (GO:0044036)4.73022986
26cell wall macromolecule catabolic process (GO:0016998)4.73022986
27vitamin transmembrane transport (GO:0035461)4.59980755
28single fertilization (GO:0007338)4.57621575
29male meiosis I (GO:0007141)4.53515393
30calcium ion-dependent exocytosis (GO:0017156)4.49680488
31ethanol metabolic process (GO:0006067)4.37846998
32S-adenosylmethionine metabolic process (GO:0046500)4.30279051
33one-carbon compound transport (GO:0019755)4.29897518
34meiotic cell cycle (GO:0051321)4.28557908
35DNA methylation involved in gamete generation (GO:0043046)4.24883919
36phosphorelay signal transduction system (GO:0000160)4.24473204
37synaptonemal complex organization (GO:0070193)4.13054748
38lung epithelium development (GO:0060428)4.09605218
39left/right pattern formation (GO:0060972)4.09520317
40ionotropic glutamate receptor signaling pathway (GO:0035235)4.06488716
41cilium morphogenesis (GO:0060271)4.05771175
42synaptonemal complex assembly (GO:0007130)4.05632123
43protein localization to cilium (GO:0061512)4.05004201
44centriole assembly (GO:0098534)4.02492411
45response to xenobiotic stimulus (GO:0009410)3.98856483
46diterpenoid biosynthetic process (GO:0016102)3.88956214
47negative regulation of inclusion body assembly (GO:0090084)3.88699893
48spermatogenesis (GO:0007283)3.80886421
49male gamete generation (GO:0048232)3.78996590
50fertilization (GO:0009566)3.77796194
51regulation of autophagic vacuole assembly (GO:2000785)3.76203927
52cell projection assembly (GO:0030031)3.73608991
53meiotic nuclear division (GO:0007126)3.72081822
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.70967827
55glutamate receptor signaling pathway (GO:0007215)3.67859168
56left/right axis specification (GO:0070986)3.65837757
57C21-steroid hormone biosynthetic process (GO:0006700)3.65214306
58microtubule polymerization or depolymerization (GO:0031109)3.57377102
59meiosis I (GO:0007127)3.55988877
60gamete generation (GO:0007276)3.52056044
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.51979742
62establishment of apical/basal cell polarity (GO:0035089)3.49520161
63calcium ion import (GO:0070509)3.47644179
64neuronal action potential propagation (GO:0019227)3.45856188
65axoneme assembly (GO:0035082)3.42431794
66organic cation transport (GO:0015695)3.40626293
67glutathione derivative biosynthetic process (GO:1901687)3.39934677
68glutathione derivative metabolic process (GO:1901685)3.39934677
69glomerular epithelial cell development (GO:0072310)3.38809451
70pyrimidine-containing compound transmembrane transport (GO:0072531)3.36077452
71cilium organization (GO:0044782)3.35960878
72regulation of vacuole organization (GO:0044088)3.35020979
73chromosome organization involved in meiosis (GO:0070192)3.33538638
74cell recognition (GO:0008037)3.33526561
75terpenoid biosynthetic process (GO:0016114)3.31953345
76cilium assembly (GO:0042384)3.30594493
77regulation of microtubule-based movement (GO:0060632)3.29668788
78intraciliary transport (GO:0042073)3.28162120
79protein polyglutamylation (GO:0018095)3.24651957
80regulation of interleukin-13 production (GO:0032656)3.21097361
81germ cell development (GO:0007281)3.18465001
82cellular response to pH (GO:0071467)3.16743460
83progesterone metabolic process (GO:0042448)3.16492772
84positive regulation of protein kinase C signaling (GO:0090037)3.16203632
85ethanol oxidation (GO:0006069)3.14131077
86cellular process involved in reproduction in multicellular organism (GO:0022412)3.09361007
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08232307
88negative regulation of translation, ncRNA-mediated (GO:0040033)3.08232307
89regulation of translation, ncRNA-mediated (GO:0045974)3.08232307
90establishment of monopolar cell polarity (GO:0061162)3.05041797
91establishment or maintenance of monopolar cell polarity (GO:0061339)3.05041797
92negative regulation of organelle assembly (GO:1902116)3.05041402
93polyamine biosynthetic process (GO:0006596)3.03248657
94neuron cell-cell adhesion (GO:0007158)3.02199908
95microtubule-based movement (GO:0007018)2.98590692
96regulation of protein kinase A signaling (GO:0010738)2.96944461
97regulation of meiosis I (GO:0060631)2.96690880
98lateral ventricle development (GO:0021670)2.94188938
99determination of left/right symmetry (GO:0007368)2.93292472
100regulation of action potential (GO:0098900)2.89621997
101membrane depolarization during action potential (GO:0086010)2.88799053
102regulation of interleukin-5 production (GO:0032674)2.88621713
103positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88295972
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88047817
105carnitine metabolic process (GO:0009437)2.87826530
106negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86478742
107determination of bilateral symmetry (GO:0009855)2.83046736
108negative regulation of T cell differentiation in thymus (GO:0033085)2.82795546
109pre-miRNA processing (GO:0031054)2.80985339
110establishment of planar polarity (GO:0001736)2.80349960
111establishment of tissue polarity (GO:0007164)2.80349960
112cytoplasmic microtubule organization (GO:0031122)2.79801167
113cellular component assembly involved in morphogenesis (GO:0010927)2.78668597
114specification of symmetry (GO:0009799)2.77630152
115nonmotile primary cilium assembly (GO:0035058)2.77109284
116oligosaccharide biosynthetic process (GO:0009312)2.77056047
117GTP biosynthetic process (GO:0006183)2.76696277
118regulation of inclusion body assembly (GO:0090083)2.76524704
119glutathione metabolic process (GO:0006749)2.74637429
120gene silencing by RNA (GO:0031047)2.74246441
121multicellular organismal reproductive process (GO:0048609)2.74044306
122microtubule-based process (GO:0007017)2.72811852
123microtubule bundle formation (GO:0001578)2.71379816
124negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70974572
125positive regulation of Rho protein signal transduction (GO:0035025)2.70452714
126synaptic transmission, glutamatergic (GO:0035249)2.70282404
127retinoic acid metabolic process (GO:0042573)2.68502424
128negative regulation of humoral immune response (GO:0002921)2.68327784
129positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.66055762
130long-chain fatty acid biosynthetic process (GO:0042759)2.65525487
131mitochondrion degradation (GO:0000422)2.65495752
132regulation of protein kinase C signaling (GO:0090036)2.63972589
133vocalization behavior (GO:0071625)2.61533783
134regulation of acrosome reaction (GO:0060046)2.59894937
135positive regulation of smoothened signaling pathway (GO:0045880)2.59766522
136cerebellum development (GO:0021549)2.58546051
137dendritic spine morphogenesis (GO:0060997)2.58289505
138nucleoside diphosphate phosphorylation (GO:0006165)2.58156350
139male genitalia development (GO:0030539)2.58098402
140extracellular fibril organization (GO:0043206)2.57657215
141muscle cell migration (GO:0014812)2.57282615
142barbed-end actin filament capping (GO:0051016)2.57253726
143carnitine transport (GO:0015879)2.57155179
144amino-acid betaine transport (GO:0015838)2.57155179
145carnitine transmembrane transport (GO:1902603)2.56543003
146hydrogen peroxide catabolic process (GO:0042744)2.55406026
147regulation of microtubule depolymerization (GO:0031114)2.54064028
148tolerance induction (GO:0002507)2.51739713
149aldehyde catabolic process (GO:0046185)2.50548012
150establishment or maintenance of bipolar cell polarity (GO:0061245)2.50336993
151establishment or maintenance of apical/basal cell polarity (GO:0035088)2.50336993
152smoothened signaling pathway (GO:0007224)2.48285055
153organelle assembly (GO:0070925)2.45364346
154lipoxygenase pathway (GO:0019372)2.43980667
155negative regulation of B cell mediated immunity (GO:0002713)2.42391013
156negative regulation of immunoglobulin mediated immune response (GO:0002890)2.42391013
157adenosine receptor signaling pathway (GO:0001973)2.41076058
158negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.38629096
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37090436
160regulation of cilium assembly (GO:1902017)2.35595990
161embryonic camera-type eye development (GO:0031076)2.35372281
162nucleotide phosphorylation (GO:0046939)2.30429440
163multicellular organismal water homeostasis (GO:0050891)2.29372852
164axonemal dynein complex assembly (GO:0070286)11.7319682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.16821537
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.21851842
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.01858437
4EZH2_22144423_ChIP-Seq_EOC_Human4.58583448
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.43557505
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.07294396
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.72735214
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.45459880
9SMC4_20622854_ChIP-Seq_HELA_Human2.33123916
10AR_21572438_ChIP-Seq_LNCaP_Human2.30051007
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.29368443
12GBX2_23144817_ChIP-Seq_PC3_Human2.02802389
13REST_21632747_ChIP-Seq_MESCs_Mouse2.00210198
14EZH2_27294783_Chip-Seq_ESCs_Mouse1.98955838
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.97383905
16ELK4_26923725_Chip-Seq_MESODERM_Mouse1.94430037
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.88949901
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85707247
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80228340
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79021821
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.78476499
22CTCF_20526341_ChIP-Seq_ESCs_Human1.78210525
23TP63_22573176_ChIP-Seq_HFKS_Human1.76881225
24ZNF263_19887448_ChIP-Seq_K562_Human1.72651563
25LXR_22292898_ChIP-Seq_THP-1_Human1.72343386
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72335703
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71027598
28STAT1_20625510_ChIP-Seq_HELA_Human1.70794538
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.68600897
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68441329
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68217453
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67888046
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67044991
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67044991
35P68_20966046_ChIP-Seq_HELA_Human1.66107431
36CTCF_27219007_Chip-Seq_Bcells_Human1.65376732
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65361424
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62001484
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.60933101
40DROSHA_22980978_ChIP-Seq_HELA_Human1.60640883
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.59724132
42RAD21_21589869_ChIP-Seq_MESCs_Mouse1.57714282
43BCAT_22108803_ChIP-Seq_LS180_Human1.55657497
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54667869
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54448348
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.53691214
47PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.53013113
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.50933952
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50903143
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.47931833
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47286438
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.46316338
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46107060
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45338005
55TP53_18474530_ChIP-ChIP_U2OS_Human1.44367958
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42695206
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.42199515
58SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.40753754
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.38851519
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38120844
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36508774
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35747251
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35017360
64AHR_22903824_ChIP-Seq_MCF-7_Human1.34708743
65SOX2_20726797_ChIP-Seq_SW620_Human1.33932622
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33592782
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33382250
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.33121922
69SMAD4_21799915_ChIP-Seq_A2780_Human1.31759514
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.29283288
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29250590
72PHF8_20622854_ChIP-Seq_HELA_Human1.28931014
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28856326
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.28731467
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28527110
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27197383
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25208540
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25177657
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.24851499
80RACK7_27058665_Chip-Seq_MCF-7_Human1.23785466
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22526928
82BCL6_27268052_Chip-Seq_Bcells_Human1.22419868
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21893093
84KLF5_25053715_ChIP-Seq_YYC3_Human1.21741988
85P53_22387025_ChIP-Seq_ESCs_Mouse1.21220168
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20858678
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20857769
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20685006
89BCOR_27268052_Chip-Seq_Bcells_Human1.20579526
90P300_18555785_Chip-Seq_ESCs_Mouse1.19069410
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.18539005
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18526076
93TDRD3_21172665_ChIP-Seq_MCF-7_Human1.17699172
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.17398949
95EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16789562
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16789562
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16751330
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16589700
99ZNF274_21170338_ChIP-Seq_K562_Hela1.15859713
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14766427
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14741622
102TP63_23658742_ChIP-Seq_EP156T_Human1.14384536
103TET1_21490601_ChIP-Seq_MESCs_Mouse1.14346007
104TAF15_26573619_Chip-Seq_HEK293_Human1.13943386
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13077792
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12949213
107RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12494678
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.11137591
109GF1_26923725_Chip-Seq_HPCs_Mouse1.10471546
110MYC_27129775_Chip-Seq_CORNEA_Mouse1.10203838
111TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09890564
112OCT4_18555785_Chip-Seq_ESCs_Mouse1.09654205
113SOX2_21211035_ChIP-Seq_LN229_Human1.09046860
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.09023921
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08944362
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08480866
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07603599
118E2F1_20622854_ChIP-Seq_HELA_Human1.07361664
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06636812
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.06099913
121OCT1_27270436_Chip-Seq_PROSTATE_Human1.05805925
122EED_16625203_ChIP-ChIP_MESCs_Mouse1.05799705
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04447934
124SPI1_20517297_ChIP-Seq_HL60_Human1.04381109
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.04198289
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03830143
127TCF4_23295773_ChIP-Seq_U87_Human1.03655699
128CREB1_26743006_Chip-Seq_LNCaP_Human1.03420958
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03337853
130RARA_24833708_ChIP-Seq_LIVER_Mouse1.02960002
131IGF1R_20145208_ChIP-Seq_DFB_Human1.02568923
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02334627
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01904669
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.01861052
135JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01551141
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01513131
137STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00912514
138SOX2_18555785_Chip-Seq_ESCs_Mouse1.00525100
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.99443220
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99315218
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99302711
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98769765
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.98423277
144STAT3_23295773_ChIP-Seq_U87_Human0.97685213
145TP53_23651856_ChIP-Seq_MEFs_Mouse0.97675675
146RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97557912
147TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97321749
148ERA_21632823_ChIP-Seq_H3396_Human0.97222000
149RING1B_27294783_Chip-Seq_ESCs_Mouse0.96835792
150RNF2_27304074_Chip-Seq_NSC_Mouse0.96593967
151TP53_22127205_ChIP-Seq_IMR90_Human0.95997958
152CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95811374
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95674605
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95654998
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95620595
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.95229431
157KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95226587
158GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.94909409
159PU1_27457419_Chip-Seq_LIVER_Mouse0.94827475
160TBL1_22424771_ChIP-Seq_293T_Human0.94574285
161KDM2B_26808549_Chip-Seq_REH_Human0.94532538
162TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94227662
163GATA1_19941826_ChIP-Seq_K562_Human0.94008116
164TET1_21451524_ChIP-Seq_MESCs_Mouse0.93810751
165P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93707804
166P300_19829295_ChIP-Seq_ESCs_Human0.93523390
167ERG_20517297_ChIP-Seq_VCAP_Human0.92770991
168GF1B_26923725_Chip-Seq_HPCs_Mouse0.92442286
169NANOG_20526341_ChIP-Seq_ESCs_Human0.92351214
170P300_27268052_Chip-Seq_Bcells_Human0.92178502
171CLOCK_20551151_ChIP-Seq_293T_Human0.91404433
172HNFA_21074721_ChIP-Seq_CACO-2_Human0.91238855
173PHF8_20622853_ChIP-Seq_HELA_Human0.90752653
174P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89920789
175ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89021605
176EOMES_21245162_ChIP-Seq_HESCs_Human0.86378546
177HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85915738
178ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85434795
179EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84739043
180GATA1_26923725_Chip-Seq_HPCs_Mouse0.84476946
181CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84420089
182CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83553707
183EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83003924
184E2F1_17053090_ChIP-ChIP_MCF-7_Human0.82804886
185CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82458015
186THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81670114
187ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80244616
188CDX2_20551321_ChIP-Seq_CACO-2_Human0.78670109
189FLI1_21867929_ChIP-Seq_CD8_Mouse0.78621053
190CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78571489
191GATA3_24758297_ChIP-Seq_MCF-7_Human0.78101555
192OCT4_20526341_ChIP-Seq_ESCs_Human0.77992524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.70772852
2MP0005409_darkened_coat_color4.57998041
3MP0002132_abnormal_respiratory_system4.55068174
4MP0008875_abnormal_xenobiotic_pharmacok4.25658899
5MP0006292_abnormal_olfactory_placode3.57318928
6MP0008789_abnormal_olfactory_epithelium3.52035612
7MP0003698_abnormal_male_reproductive3.39029435
8MP0009780_abnormal_chondrocyte_physiolo3.32996401
9MP0003136_yellow_coat_color3.15094753
10MP0005499_abnormal_olfactory_system3.11488389
11MP0004859_abnormal_synaptic_plasticity3.04714276
12MP0008004_abnormal_stomach_pH3.01153692
13MP0009046_muscle_twitch3.00337867
14MP0001929_abnormal_gametogenesis2.95963176
15MP0005248_abnormal_Harderian_gland2.89207326
16MP0003880_abnormal_central_pattern2.75870249
17MP0004133_heterotaxia2.54674409
18MP0003635_abnormal_synaptic_transmissio2.38085129
19MP0001486_abnormal_startle_reflex2.21784301
20MP0001188_hyperpigmentation2.15393498
21MP0005174_abnormal_tail_pigmentation2.05959077
22MP0004270_analgesia2.04887800
23MP0005464_abnormal_platelet_physiology1.98068492
24MP0001968_abnormal_touch/_nociception1.96587367
25MP0002234_abnormal_pharynx_morphology1.93400772
26MP0001849_ear_inflammation1.92729599
27MP0004233_abnormal_muscle_weight1.87843022
28MP0000383_abnormal_hair_follicle1.86324310
29MP0010030_abnormal_orbit_morphology1.85383136
30MP0002161_abnormal_fertility/fecundity1.80779193
31MP0005377_hearing/vestibular/ear_phenot1.80268438
32MP0003878_abnormal_ear_physiology1.80268438
33MP0000015_abnormal_ear_pigmentation1.75641424
34MP0002638_abnormal_pupillary_reflex1.73321415
35MP0009745_abnormal_behavioral_response1.70395545
36MP0005623_abnormal_meninges_morphology1.65824051
37MP0002210_abnormal_sex_determination1.61314842
38MP0005058_abnormal_lysosome_morphology1.57481970
39MP0001984_abnormal_olfaction1.56582097
40MP0004381_abnormal_hair_follicle1.56355559
41MP0001346_abnormal_lacrimal_gland1.55720721
42MP0005670_abnormal_white_adipose1.55240548
43MP0002064_seizures1.54377513
44MP0010678_abnormal_skin_adnexa1.53906112
45MP0003879_abnormal_hair_cell1.53312636
46MP0001145_abnormal_male_reproductive1.51827245
47MP0005083_abnormal_biliary_tract1.50416192
48MP0002877_abnormal_melanocyte_morpholog1.49412206
49MP0005167_abnormal_blood-brain_barrier1.47657588
50MP0002277_abnormal_respiratory_mucosa1.47540538
51MP0002572_abnormal_emotion/affect_behav1.45936959
52MP0002282_abnormal_trachea_morphology1.44725692
53MP0002653_abnormal_ependyma_morphology1.43354856
54MP0002063_abnormal_learning/memory/cond1.41447583
55MP0002160_abnormal_reproductive_system1.40754431
56MP0004019_abnormal_vitamin_homeostasis1.40502458
57MP0006072_abnormal_retinal_apoptosis1.39673290
58MP0002734_abnormal_mechanical_nocicepti1.35230022
59MP0000653_abnormal_sex_gland1.34808583
60MP0002233_abnormal_nose_morphology1.34620212
61MP0005647_abnormal_sex_gland1.33917395
62MP0000343_altered_response_to1.32604167
63MP0000747_muscle_weakness1.30832896
64MP0005165_increased_susceptibility_to1.30674836
65MP0005646_abnormal_pituitary_gland1.27710269
66MP0002272_abnormal_nervous_system1.27700872
67MP0002736_abnormal_nociception_after1.26980790
68MP0002102_abnormal_ear_morphology1.22832026
69MP0002557_abnormal_social/conspecific_i1.20827446
70MP0000681_abnormal_thyroid_gland1.17567410
71MP0005551_abnormal_eye_electrophysiolog1.17454704
72MP0002735_abnormal_chemical_nociception1.15867877
73MP0000778_abnormal_nervous_system1.14141645
74MP0003656_abnormal_erythrocyte_physiolo1.13967253
75MP0001879_abnormal_lymphatic_vessel1.13082313
76MP0003938_abnormal_ear_development1.13015921
77MP0000631_abnormal_neuroendocrine_gland1.07153870
78MP0002067_abnormal_sensory_capabilities1.06313868
79MP0001529_abnormal_vocalization1.06047849
80MP0004811_abnormal_neuron_physiology1.04607956
81MP0001661_extended_life_span1.02511514
82MP0003075_altered_response_to1.01543108
83MP0000566_synostosis1.01311035
84MP0005253_abnormal_eye_physiology0.99038125
85MP0000955_abnormal_spinal_cord0.98599219
86MP0004272_abnormal_basement_membrane0.98392588
87MP0001501_abnormal_sleep_pattern0.97963774
88MP0002184_abnormal_innervation0.95182527
89MP0001485_abnormal_pinna_reflex0.94683113
90MP0003329_amyloid_beta_deposits0.94051571
91MP0000465_gastrointestinal_hemorrhage0.94044585
92MP0002971_abnormal_brown_adipose0.93145506
93MP0008877_abnormal_DNA_methylation0.92726481
94MP0001765_abnormal_ion_homeostasis0.90781693
95MP0002177_abnormal_outer_ear0.90564795
96MP0002152_abnormal_brain_morphology0.89642420
97MP0001177_atelectasis0.88135624
98MP0003045_fibrosis0.87433944
99MP0003566_abnormal_cell_adhesion0.86849332
100MP0009379_abnormal_foot_pigmentation0.86740374
101MP0001963_abnormal_hearing_physiology0.86351421
102MP0004885_abnormal_endolymph0.85418545
103MP0004130_abnormal_muscle_cell0.84075223
104MP0009250_abnormal_appendicular_skeleto0.83714094
105MP0002733_abnormal_thermal_nociception0.83202441
106MP0002249_abnormal_larynx_morphology0.82752696
107MP0000358_abnormal_cell_content/0.81114585
108MP0001664_abnormal_digestion0.80980152
109MP0002882_abnormal_neuron_morphology0.80779825
110MP0000462_abnormal_digestive_system0.80510180
111MP0005423_abnormal_somatic_nervous0.79088570
112MP0002168_other_aberrant_phenotype0.77743388
113MP0003453_abnormal_keratinocyte_physiol0.77696793
114MP0001440_abnormal_grooming_behavior0.76611142
115MP0005595_abnormal_vascular_smooth0.76153107
116MP0002752_abnormal_somatic_nervous0.75964362
117MP0002269_muscular_atrophy0.74790694
118MP0003186_abnormal_redox_activity0.74145653
119MP0005395_other_phenotype0.74001078
120MP0003191_abnormal_cellular_cholesterol0.73647693
121MP0003861_abnormal_nervous_system0.73583699
122MP0003942_abnormal_urinary_system0.73562490
123MP0000428_abnormal_craniofacial_morphol0.72295817
124MP0000751_myopathy0.71969057
125MP0002909_abnormal_adrenal_gland0.71014229
126MP0008260_abnormal_autophagy0.70809936
127MP0005391_vision/eye_phenotype0.70738740
128MP0000026_abnormal_inner_ear0.70685301
129MP0001970_abnormal_pain_threshold0.70575229
130MP0004742_abnormal_vestibular_system0.69614322
131MP0008569_lethality_at_weaning0.69052657
132MP0003634_abnormal_glial_cell0.68934403
133MP0002066_abnormal_motor_capabilities/c0.68136395
134MP0004043_abnormal_pH_regulation0.66396440
135MP0000678_abnormal_parathyroid_gland0.65535841
136MP0006036_abnormal_mitochondrial_physio0.64725960
137MP0005451_abnormal_body_composition0.64393311
138MP0010368_abnormal_lymphatic_system0.63995778
139MP0003631_nervous_system_phenotype0.62277993
140MP0003718_maternal_effect0.62120692
141MP0005379_endocrine/exocrine_gland_phen0.62029454
142MP0003633_abnormal_nervous_system0.61692502
143MP0001299_abnormal_eye_distance/0.60549713
144MP0001905_abnormal_dopamine_level0.60330682
145MP0001293_anophthalmia0.60069439
146MP0000579_abnormal_nail_morphology0.59557494
147MP0003941_abnormal_skin_development0.58701459
148MP0002822_catalepsy0.57819555
149MP0000762_abnormal_tongue_morphology0.57658611
150MP0003115_abnormal_respiratory_system0.56941103
151MP0005394_taste/olfaction_phenotype0.56814677
152MP0005389_reproductive_system_phenotype0.56079553
153MP0002295_abnormal_pulmonary_circulatio0.54298736
154MP0009053_abnormal_anal_canal0.54221109
155MP0003632_abnormal_nervous_system0.54203355
156MP0002229_neurodegeneration0.54124344
157MP0005171_absent_coat_pigmentation0.53899042
158MP0001502_abnormal_circadian_rhythm0.53481568
159MP0000049_abnormal_middle_ear0.53443572
160MP0002092_abnormal_eye_morphology0.52220043

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.91788311
2Absent/shortened dynein arms (HP:0200106)8.91788311
3Abnormal respiratory motile cilium physiology (HP:0012261)8.73854119
4Abnormal respiratory motile cilium morphology (HP:0005938)7.56109695
5Abnormal respiratory epithelium morphology (HP:0012253)7.56109695
6Rhinitis (HP:0012384)7.16632308
7Abnormal ciliary motility (HP:0012262)7.14248517
8Chronic bronchitis (HP:0004469)5.74755718
9Elfin facies (HP:0004428)4.51226919
10Nasal polyposis (HP:0100582)4.45994365
11Hyperacusis (HP:0010780)4.45192953
12Renovascular hypertension (HP:0100817)4.40386303
13Overriding aorta (HP:0002623)4.29514354
14Sensory axonal neuropathy (HP:0003390)4.29388021
15Infertility (HP:0000789)4.25812418
16Male infertility (HP:0003251)4.23936690
17Insomnia (HP:0100785)4.06136875
18Flat cornea (HP:0007720)4.00850082
19Toxemia of pregnancy (HP:0100603)3.83152752
20Renal duplication (HP:0000075)3.82034166
21Bronchiectasis (HP:0002110)3.75931667
22Abnormality of the nasal mucosa (HP:0000433)3.54600317
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.26184874
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.26184874
25Tubulointerstitial nephritis (HP:0001970)3.19289266
26Polygenic inheritance (HP:0010982)3.10868594
27Atelectasis (HP:0100750)3.07646536
28Nephronophthisis (HP:0000090)3.05229549
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85999164
30Hyporeflexia of lower limbs (HP:0002600)2.85809053
31Abnormality of the diencephalon (HP:0010662)2.84690291
32Chronic sinusitis (HP:0011109)2.79061228
33Insidious onset (HP:0003587)2.76120028
34Termporal pattern (HP:0011008)2.76120028
35Tubular atrophy (HP:0000092)2.69881332
36Bronchitis (HP:0012387)2.66906735
37Abnormality of the corticospinal tract (HP:0002492)2.64822379
38Morphological abnormality of the pyramidal tract (HP:0002062)2.59581901
39Impaired vibration sensation in the lower limbs (HP:0002166)2.53950338
40Abnormality of midbrain morphology (HP:0002418)2.45819013
41Molar tooth sign on MRI (HP:0002419)2.45819013
42Recurrent otitis media (HP:0000403)2.40111093
43Genetic anticipation (HP:0003743)2.33193370
44Hyperactive renin-angiotensin system (HP:0000841)2.32718201
45Chronic otitis media (HP:0000389)2.29934937
46Occipital encephalocele (HP:0002085)2.28325029
47Abnormal biliary tract physiology (HP:0012439)2.23057937
48Bile duct proliferation (HP:0001408)2.23057937
49Abnormality of the renal medulla (HP:0100957)2.22170282
50Bladder diverticulum (HP:0000015)2.21294518
51Arnold-Chiari malformation (HP:0002308)2.18062688
52Increased nuchal translucency (HP:0010880)2.15546481
53Bell-shaped thorax (HP:0001591)2.10782463
54Recurrent sinusitis (HP:0011108)2.08594271
55Medial flaring of the eyebrow (HP:0010747)2.05595848
56Curly hair (HP:0002212)2.05270384
57Truncal ataxia (HP:0002078)2.03744546
58Anencephaly (HP:0002323)2.03382841
59Urinary bladder sphincter dysfunction (HP:0002839)2.02762946
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4484397
61Bowel diverticulosis (HP:0005222)1.98964625
62Pancreatic cysts (HP:0001737)1.95590890
63Urinary urgency (HP:0000012)1.94965290
64Focal motor seizures (HP:0011153)1.94733295
65Chronic hepatic failure (HP:0100626)1.92323553
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.88437851
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88256034
68Stage 5 chronic kidney disease (HP:0003774)1.87969159
69Sclerocornea (HP:0000647)1.86864313
70Hand muscle atrophy (HP:0009130)1.85256684
71Congenital hepatic fibrosis (HP:0002612)1.84695716
72Pancreatic fibrosis (HP:0100732)1.80488056
73Tubulointerstitial abnormality (HP:0001969)1.80483277
74True hermaphroditism (HP:0010459)1.79781028
75Short nail (HP:0001799)1.79121144
76Supernumerary spleens (HP:0009799)1.78805611
77Megalocornea (HP:0000485)1.78656569
78Median cleft lip (HP:0000161)1.78267941
79Postaxial foot polydactyly (HP:0001830)1.77229455
80Upper limb muscle weakness (HP:0003484)1.74544862
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73109248
82Gait imbalance (HP:0002141)1.72229828
83Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.72017194
84Steppage gait (HP:0003376)1.71237218
85Absent frontal sinuses (HP:0002688)1.70955829
86Gaze-evoked nystagmus (HP:0000640)1.70909651
87Nuclear cataract (HP:0100018)1.69701628
88Nephrogenic diabetes insipidus (HP:0009806)1.67642923
89Hypercalciuria (HP:0002150)1.66832065
90Patellar dislocation (HP:0002999)1.66631656
91Areflexia of lower limbs (HP:0002522)1.66086320
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.65556930
93Abnormality of the lower motor neuron (HP:0002366)1.64985748
94Ankyloglossia (HP:0010296)1.63858253
95Abnormality of molar (HP:0011077)1.63841256
96Abnormality of molar morphology (HP:0011070)1.63841256
97Male pseudohermaphroditism (HP:0000037)1.62843390
98Renal salt wasting (HP:0000127)1.62713542
99Congenital primary aphakia (HP:0007707)1.61574101
100Purpura (HP:0000979)1.61419521
101Nephropathy (HP:0000112)1.61388529
102Polycystic kidney dysplasia (HP:0000113)1.60683752
103Postaxial hand polydactyly (HP:0001162)1.60589017
104Multifactorial inheritance (HP:0001426)1.60336423
105Hypercalcemia (HP:0003072)1.60316544
106Cystic liver disease (HP:0006706)1.58645712
107Impaired vibratory sensation (HP:0002495)1.55189304
108Abnormality of the carotid arteries (HP:0005344)1.54992345
109Pointed chin (HP:0000307)1.51660441
110Abnormality of permanent molar morphology (HP:0011071)1.51463983
111Abnormality of the dental root (HP:0006486)1.51463983
112Taurodontia (HP:0000679)1.51463983
113Neurofibrillary tangles (HP:0002185)1.51445004
114Abnormality of dentin (HP:0010299)1.50795850
115Spastic paraplegia (HP:0001258)1.48579052
116Oculomotor apraxia (HP:0000657)1.48247819
117Hemiparesis (HP:0001269)1.47951907
118Paraplegia (HP:0010550)1.47619979
119Upper limb amyotrophy (HP:0009129)1.47344380
120Distal upper limb amyotrophy (HP:0007149)1.47344380
121Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.47127661
122Broad distal phalanx of finger (HP:0009836)1.46688323
123Lower limb muscle weakness (HP:0007340)1.45788490
124Osteomalacia (HP:0002749)1.45578168
125Abnormality of the frontal sinuses (HP:0002687)1.44672114
126Preaxial hand polydactyly (HP:0001177)1.43749880
127Asplenia (HP:0001746)1.43633587
128Breech presentation (HP:0001623)1.42809797
129Obsessive-compulsive behavior (HP:0000722)1.42808586
130Dyschromatopsia (HP:0007641)1.37298993
131Poor coordination (HP:0002370)1.33195943
132Vaginal atresia (HP:0000148)1.32011281
133Bifid scrotum (HP:0000048)1.28891872
134Short femoral neck (HP:0100864)1.28801402
135Genital tract atresia (HP:0001827)1.27737478
136Renal dysplasia (HP:0000110)1.26157727
137Furrowed tongue (HP:0000221)1.25920437
138Abnormality of the distal phalanges of the toes (HP:0010182)1.23763035
139Menorrhagia (HP:0000132)1.23502715
140Glucose intolerance (HP:0000833)1.21102567
141Hyperaldosteronism (HP:0000859)1.16848061
142Short thorax (HP:0010306)1.16779190
143Hypoplasia of the uterus (HP:0000013)1.14683939
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.13863247
145Facial cleft (HP:0002006)1.12236535
146Down-sloping shoulders (HP:0200021)1.11360905
147Aplasia/Hypoplasia of the lens (HP:0008063)1.10956161
148Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.10939994
149Abnormality of the dental pulp (HP:0006479)1.10770189
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.08804670
151Retinal dysplasia (HP:0007973)1.08076014
152Recurrent corneal erosions (HP:0000495)1.04254001
153Self-mutilation (HP:0000742)1.03179597
154Decreased central vision (HP:0007663)1.01124005
155Hypokalemic alkalosis (HP:0001949)1.00161124
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.00116587
157Absent epiphyses (HP:0010577)1.00116587
158Aganglionic megacolon (HP:0002251)0.98509404
159Hyponatremia (HP:0002902)0.97929208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.92616971
2PDK35.92616971
3MST45.71379242
4EPHA23.80508753
5BLK3.60914763
6PDK23.46262294
7GRK13.33443384
8MAP3K93.20557469
9SIK23.16887520
10MAPK153.04983927
11EPHA43.01008605
12CASK2.93061901
13PINK12.82612274
14PRKD32.70243250
15YES12.19097894
16CCNB12.07430786
17ARAF2.02669609
18MAPKAPK31.98561399
19TESK11.97143166
20ICK1.87628355
21RIPK41.82336877
22MYLK1.75597125
23TNK21.73928352
24BMX1.73853877
25PNCK1.66273116
26NME11.62177038
27BCR1.61602303
28MARK31.58239236
29PTK2B1.50132987
30MST1R1.41471965
31PIK3CG1.36434152
32SMG11.33183398
33AKT31.27288723
34PBK1.26991076
35TNIK1.25887790
36PIM21.20353472
37ERBB41.18851011
38LRRK21.15847465
39NTRK31.10662598
40NTRK21.08952359
41CAMK2G1.07937722
42NEK61.07664521
43INSRR1.06784793
44BMPR21.04594778
45ILK1.01405282
46TLK11.00777774
47STK381.00350943
48ADRBK20.96240378
49PRKCG0.95948709
50NME20.95511627
51PRPF4B0.92930560
52LIMK10.92719992
53MAP3K120.91133267
54MAP3K20.90635554
55PAK10.88726113
56AURKA0.88578296
57NTRK10.88490784
58MAP3K30.88248707
59PDK10.87225279
60CDC42BPA0.86539833
61MARK20.85034288
62SIK10.84594096
63TTK0.84319688
64NEK90.83813255
65STK38L0.83636051
66STK240.81011523
67BRAF0.80261696
68MAP2K40.78455002
69STK100.78247282
70ROCK20.75861686
71EEF2K0.75501557
72EPHB20.75484117
73MAP2K70.74161718
74PRKD20.72617044
75WNK40.72043669
76BMPR1B0.70281621
77IRAK10.70096232
78PDPK10.69151947
79STK390.67908866
80PDGFRB0.67717244
81MAP3K10.66558961
82RET0.65348650
83EIF2AK10.65008932
84IRAK20.64568071
85PRKCI0.64214362
86HCK0.64185265
87ABL20.63026802
88MAPK130.62961724
89ERBB30.61406408
90CDK80.61255854
91FGR0.61184123
92PLK20.60100757
93AKT20.60093003
94SGK20.59689456
95BCKDK0.59305993
96CSNK1G30.57051289
97TYK20.56865529
98LATS20.56564815
99STK160.55104517
100ROCK10.54987955
101CSNK1G20.53724997
102SGK4940.53589182
103SGK2230.53589182
104MAP3K40.52943284
105TRIB30.52509957
106PTK20.51780364
107CSNK1A1L0.50398135
108EPHA30.48782972
109PAK40.48451811
110HIPK20.48273581
111CDK140.47930763
112WNK10.47660991
113CSK0.47114065
114EPHB10.46698518
115CAMK2A0.45915053
116MOS0.44582892
117PLK10.44157913
118PAK60.43825832
119MAPK70.43258744
120MAP3K110.42732919
121ERBB20.42507319
122CDK50.40676409
123TRIM280.40511361
124SGK30.40391672
125CAMKK10.40311629
126STK30.39473123
127MARK10.38389912
128DYRK30.38288915
129LMTK20.35111637
130TAOK20.34614973
131PRKG10.34508273
132MAP3K50.33668901
133SIK30.32525302
134MAPK100.32153229
135IRAK40.31685487
136FER0.30730288
137SGK10.30173086
138IRAK30.29949919
139SRPK10.29716902
140NEK20.28995725
141RPS6KA50.28942808
142MAPKAPK50.27883694
143MINK10.27117592
144FES0.26830253
145BRD40.26557708
146MUSK0.26502994
147PRKCQ0.25885299
148SRC0.24542330
149CAMK1G0.23730077
150WEE10.23684968
151GRK50.22618553
152PRKCE0.21846562
153CAMK10.21651966
154FYN0.21184123
155ZAK0.20362000
156PKN10.19962083
157UHMK10.19371777
158PHKG20.18883016
159PHKG10.18883016
160MET0.18881257
161DYRK1B0.18411079
162DMPK0.17499978
163CDK60.15284300
164PRKCB0.13504084

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.28131970
2Phenylalanine metabolism_Homo sapiens_hsa003604.16960911
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.55456753
4Nicotine addiction_Homo sapiens_hsa050333.51605244
5Tyrosine metabolism_Homo sapiens_hsa003503.42489339
6Glutathione metabolism_Homo sapiens_hsa004803.38178463
7Chemical carcinogenesis_Homo sapiens_hsa052043.33020331
8Histidine metabolism_Homo sapiens_hsa003403.22807482
9beta-Alanine metabolism_Homo sapiens_hsa004103.12979100
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.08959494
11Gastric acid secretion_Homo sapiens_hsa049712.46259264
12Amphetamine addiction_Homo sapiens_hsa050312.39375320
13Glutamatergic synapse_Homo sapiens_hsa047242.33323886
14Huntingtons disease_Homo sapiens_hsa050162.20780370
15Circadian entrainment_Homo sapiens_hsa047131.95970644
16Vitamin B6 metabolism_Homo sapiens_hsa007501.92574199
17Morphine addiction_Homo sapiens_hsa050321.87362917
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86563276
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82622539
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77745956
21Cocaine addiction_Homo sapiens_hsa050301.74828309
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74346168
23Dorso-ventral axis formation_Homo sapiens_hsa043201.72623252
24Steroid biosynthesis_Homo sapiens_hsa001001.70917909
25Insulin secretion_Homo sapiens_hsa049111.66862417
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.64394130
27Fatty acid biosynthesis_Homo sapiens_hsa000611.62781121
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62705809
29Salivary secretion_Homo sapiens_hsa049701.58166941
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57928397
31Long-term potentiation_Homo sapiens_hsa047201.57759837
32Sphingolipid metabolism_Homo sapiens_hsa006001.55723546
33Renin secretion_Homo sapiens_hsa049241.53491567
34Fanconi anemia pathway_Homo sapiens_hsa034601.46759252
35Arginine and proline metabolism_Homo sapiens_hsa003301.43474187
36Pentose phosphate pathway_Homo sapiens_hsa000301.39661735
37Ovarian steroidogenesis_Homo sapiens_hsa049131.39415645
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37320073
39Long-term depression_Homo sapiens_hsa047301.37142517
40cAMP signaling pathway_Homo sapiens_hsa040241.34754775
41Linoleic acid metabolism_Homo sapiens_hsa005911.33020951
42GnRH signaling pathway_Homo sapiens_hsa049121.32368492
43Synaptic vesicle cycle_Homo sapiens_hsa047211.31726807
44GABAergic synapse_Homo sapiens_hsa047271.29784914
45Dopaminergic synapse_Homo sapiens_hsa047281.27163993
46Olfactory transduction_Homo sapiens_hsa047401.25883183
47Glucagon signaling pathway_Homo sapiens_hsa049221.24581850
48Oxytocin signaling pathway_Homo sapiens_hsa049211.24145307
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23455013
50Tight junction_Homo sapiens_hsa045301.23275211
51Calcium signaling pathway_Homo sapiens_hsa040201.22751122
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22702216
53Retinol metabolism_Homo sapiens_hsa008301.22663350
54ErbB signaling pathway_Homo sapiens_hsa040121.22300285
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19303538
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19284733
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19202119
58Taste transduction_Homo sapiens_hsa047421.15127158
59Peroxisome_Homo sapiens_hsa041461.08896708
60Collecting duct acid secretion_Homo sapiens_hsa049661.08785865
61Phototransduction_Homo sapiens_hsa047441.07011800
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06153906
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03735797
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01907782
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00318324
66Homologous recombination_Homo sapiens_hsa034400.98647675
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.98106637
68Estrogen signaling pathway_Homo sapiens_hsa049150.97219660
69Glycerolipid metabolism_Homo sapiens_hsa005610.96542047
70Melanogenesis_Homo sapiens_hsa049160.95861649
71Adherens junction_Homo sapiens_hsa045200.93342697
72Inositol phosphate metabolism_Homo sapiens_hsa005620.93010974
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92834525
74Vibrio cholerae infection_Homo sapiens_hsa051100.91262003
75Caffeine metabolism_Homo sapiens_hsa002320.90599091
76Notch signaling pathway_Homo sapiens_hsa043300.90596427
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90223727
78Ether lipid metabolism_Homo sapiens_hsa005650.89789466
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88208131
80Hedgehog signaling pathway_Homo sapiens_hsa043400.87504994
81Pancreatic secretion_Homo sapiens_hsa049720.86927729
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86233911
83Serotonergic synapse_Homo sapiens_hsa047260.86218440
84ECM-receptor interaction_Homo sapiens_hsa045120.85688465
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.85054543
86Oocyte meiosis_Homo sapiens_hsa041140.85027076
87Sulfur metabolism_Homo sapiens_hsa009200.84978473
88Cholinergic synapse_Homo sapiens_hsa047250.83930541
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83349216
90Endocytosis_Homo sapiens_hsa041440.83263334
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82977225
92Lysosome_Homo sapiens_hsa041420.82782405
93Phagosome_Homo sapiens_hsa041450.82649752
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.81352940
95Alcoholism_Homo sapiens_hsa050340.79412222
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.78145590
97Arachidonic acid metabolism_Homo sapiens_hsa005900.76262693
98Thyroid hormone synthesis_Homo sapiens_hsa049180.73735872
99Axon guidance_Homo sapiens_hsa043600.72858528
100Type II diabetes mellitus_Homo sapiens_hsa049300.69533855
101Gap junction_Homo sapiens_hsa045400.69468339
102PPAR signaling pathway_Homo sapiens_hsa033200.69436093
103Basal cell carcinoma_Homo sapiens_hsa052170.69009672
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64636666
105Sulfur relay system_Homo sapiens_hsa041220.64068478
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63539712
107Fatty acid degradation_Homo sapiens_hsa000710.63467312
108Wnt signaling pathway_Homo sapiens_hsa043100.63417421
109ABC transporters_Homo sapiens_hsa020100.63271437
110MAPK signaling pathway_Homo sapiens_hsa040100.63087511
111Hippo signaling pathway_Homo sapiens_hsa043900.61663879
112Selenocompound metabolism_Homo sapiens_hsa004500.61003197
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60293267
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.57126332
115Metabolic pathways_Homo sapiens_hsa011000.55752839
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.55649600
117Mineral absorption_Homo sapiens_hsa049780.55569359
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53842168
119Systemic lupus erythematosus_Homo sapiens_hsa053220.52196307
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.51913304
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50877575
122Circadian rhythm_Homo sapiens_hsa047100.50676851
123Pyrimidine metabolism_Homo sapiens_hsa002400.49554714
124Apoptosis_Homo sapiens_hsa042100.49045023
125Nitrogen metabolism_Homo sapiens_hsa009100.48367711
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48263835
127Rap1 signaling pathway_Homo sapiens_hsa040150.47787130
128Starch and sucrose metabolism_Homo sapiens_hsa005000.47222876
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46492705
130Purine metabolism_Homo sapiens_hsa002300.46193356
131Cardiac muscle contraction_Homo sapiens_hsa042600.45547975
132Pyruvate metabolism_Homo sapiens_hsa006200.44996831
133Bile secretion_Homo sapiens_hsa049760.44609709
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44278290
135Choline metabolism in cancer_Homo sapiens_hsa052310.43720961
136Folate biosynthesis_Homo sapiens_hsa007900.42985214
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38528429
138Biosynthesis of amino acids_Homo sapiens_hsa012300.38119142
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37963890
140Endometrial cancer_Homo sapiens_hsa052130.37618648
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.37393711
142Nucleotide excision repair_Homo sapiens_hsa034200.36969313
143Ras signaling pathway_Homo sapiens_hsa040140.36964286
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35849449
145Galactose metabolism_Homo sapiens_hsa000520.34956170
146Prolactin signaling pathway_Homo sapiens_hsa049170.34007342
147Platelet activation_Homo sapiens_hsa046110.33850147
148Dilated cardiomyopathy_Homo sapiens_hsa054140.33801742
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33225603
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.32478878
151Fructose and mannose metabolism_Homo sapiens_hsa000510.32475826
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31202596
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.31140457
154Carbon metabolism_Homo sapiens_hsa012000.30895489
155Fatty acid metabolism_Homo sapiens_hsa012120.30869055
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30231611
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26979945
158N-Glycan biosynthesis_Homo sapiens_hsa005100.26214170
159Propanoate metabolism_Homo sapiens_hsa006400.24548344

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