FAM187B2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of mitochondrion localization, microtubule-mediated (GO:0034643)7.54522355
2mitochondrion transport along microtubule (GO:0047497)7.54522355
3establishment of mitochondrion localization (GO:0051654)6.54149726
4membrane budding (GO:0006900)6.34353693
5protein neddylation (GO:0045116)5.63949156
6zinc ion transmembrane transport (GO:0071577)5.38333704
7long term synaptic depression (GO:0060292)5.32228607
8apoptotic DNA fragmentation (GO:0006309)5.28072648
9thrombin receptor signaling pathway (GO:0070493)5.07520703
10regulation of female receptivity (GO:0045924)4.91775028
11positive regulation of lamellipodium assembly (GO:0010592)4.80573823
12positive regulation of Rho protein signal transduction (GO:0035025)4.70980544
13regulation of germinal center formation (GO:0002634)4.61411811
14tRNA methylation (GO:0030488)4.55054564
15regulation of transmission of nerve impulse (GO:0051969)4.51650072
16Arp2/3 complex-mediated actin nucleation (GO:0034314)4.25727005
17regulation of lipoprotein metabolic process (GO:0050746)4.23250774
18execution phase of apoptosis (GO:0097194)4.19980385
19female mating behavior (GO:0060180)4.18979318
20regulation of cholesterol efflux (GO:0010874)4.18091805
21peptidyl-histidine modification (GO:0018202)4.14755513
22negative regulation of protein oligomerization (GO:0032460)4.00850371
23negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.00689887
24positive regulation of isotype switching (GO:0045830)3.85760221
25positive regulation of systemic arterial blood pressure (GO:0003084)3.77853910
26sequestering of actin monomers (GO:0042989)3.77142773
27actin nucleation (GO:0045010)3.76876313
28fusion of sperm to egg plasma membrane (GO:0007342)3.75192490
29zinc ion homeostasis (GO:0055069)3.75019437
30auditory receptor cell stereocilium organization (GO:0060088)3.67697714
31phenol-containing compound catabolic process (GO:0019336)3.60239698
32lipoxygenase pathway (GO:0019372)3.59411529
33male meiosis (GO:0007140)3.58794793
34positive regulation of lamellipodium organization (GO:1902745)3.56135023
35energy homeostasis (GO:0097009)3.53117354
36TOR signaling (GO:0031929)3.48183035
37regulation of platelet aggregation (GO:0090330)3.43418698
38positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.41640083
39mannose metabolic process (GO:0006013)3.40878929
40prenylation (GO:0097354)3.39806338
41protein prenylation (GO:0018342)3.39806338
42positive regulation of DNA recombination (GO:0045911)3.39585678
43positive regulation of endothelial cell differentiation (GO:0045603)3.39227517
44valine metabolic process (GO:0006573)3.38763671
45positive regulation of gamma-delta T cell activation (GO:0046645)3.37094744
46G-protein coupled receptor internalization (GO:0002031)3.32179136
47cardiolipin metabolic process (GO:0032048)3.31969994
48blood coagulation, intrinsic pathway (GO:0007597)3.30599248
49negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.28265446
50beta-amyloid metabolic process (GO:0050435)3.26298784
51regulation of macrophage derived foam cell differentiation (GO:0010743)3.23374071
52regulation of platelet activation (GO:0010543)3.22790822
53purinergic nucleotide receptor signaling pathway (GO:0035590)3.19951787
54multicellular organism reproduction (GO:0032504)3.18053011
55mitochondrion localization (GO:0051646)3.15550879
56aggressive behavior (GO:0002118)3.13062128
57positive regulation of natural killer cell differentiation (GO:0032825)3.12157607
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10028431
59high-density lipoprotein particle remodeling (GO:0034375)3.09569593
60zinc ion transport (GO:0006829)3.08878189
61negative regulation of cAMP-mediated signaling (GO:0043951)3.07452178
62negative regulation of norepinephrine secretion (GO:0010700)3.03940814
63positive regulation of amino acid transport (GO:0051957)3.03391224
64positive regulation of fatty acid biosynthetic process (GO:0045723)2.97832840
65neutrophil activation involved in immune response (GO:0002283)2.97375186
66platelet aggregation (GO:0070527)2.95731103
67positive regulation of B cell mediated immunity (GO:0002714)2.91583158
68positive regulation of immunoglobulin mediated immune response (GO:0002891)2.91583158
69reverse cholesterol transport (GO:0043691)2.90894219
70adenosine receptor signaling pathway (GO:0001973)2.89712185
71G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.89583678
72positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.87362727
73pentose metabolic process (GO:0019321)2.85923676
74negative regulation of T-helper cell differentiation (GO:0045623)2.85087012
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85087012
76antigen processing and presentation via MHC class Ib (GO:0002475)2.83228231
77phosphatidylserine acyl-chain remodeling (GO:0036150)2.83190852
78positive regulation of lipoprotein lipase activity (GO:0051006)2.81858140
79positive regulation of triglyceride lipase activity (GO:0061365)2.81858140
80regulation of integrin activation (GO:0033623)2.80253967
81negative regulation of lipid storage (GO:0010888)2.79287983
82regulation of gamma-delta T cell differentiation (GO:0045586)2.78162660
83activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.77092518
84ADP metabolic process (GO:0046031)2.76665154
85RNA destabilization (GO:0050779)2.74999366
86positive regulation of prostaglandin secretion (GO:0032308)2.72110208
87phosphatidylinositol acyl-chain remodeling (GO:0036149)2.71222596
88relaxation of smooth muscle (GO:0044557)2.70190376
89low-density lipoprotein particle remodeling (GO:0034374)2.69996530
90plasma membrane fusion (GO:0045026)2.69335984
91positive regulation of organic acid transport (GO:0032892)2.69332888
92regulation of catecholamine metabolic process (GO:0042069)2.67313871
93regulation of dopamine metabolic process (GO:0042053)2.67313871
94regulation of glutamate secretion (GO:0014048)2.66262199
95phosphatidic acid biosynthetic process (GO:0006654)2.66089338
96phosphatidic acid metabolic process (GO:0046473)2.66089338
97positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.65256363
98dicarboxylic acid catabolic process (GO:0043649)2.63839879
99oxidative demethylation (GO:0070989)2.63351170
100neurotransmitter catabolic process (GO:0042135)2.63337985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.17036997
2SRY_22984422_ChIP-ChIP_TESTIS_Rat4.98574007
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.32030609
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.90716221
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69488300
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45290172
7SCL_19346495_ChIP-Seq_HPC-7_Human2.38355238
8ELF1_20517297_ChIP-Seq_JURKAT_Human2.32632647
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28453464
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.24475257
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19786331
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.17473279
13STAT1_20625510_ChIP-Seq_HELA_Human2.14705739
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.13367995
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12799165
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.00472246
17STAT6_21828071_ChIP-Seq_BEAS2B_Human11.1882357
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.91659779
19LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.83437911
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79619009
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78175071
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77195353
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.66571710
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61791050
25SPI1_20517297_ChIP-Seq_HL60_Human1.60524176
26SPI1_23127762_ChIP-Seq_K562_Human1.59916575
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55693101
28GATA1_19941827_ChIP-Seq_MEL_Mouse1.54332839
29GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54157705
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.53966003
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47012518
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45820328
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43956274
34GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33725934
35GATA1_19941826_ChIP-Seq_K562_Human1.30707638
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28036844
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.24482433
38GBX2_23144817_ChIP-Seq_PC3_Human1.20332574
39P300_27268052_Chip-Seq_Bcells_Human1.19168796
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.18639190
41E2F1_20622854_ChIP-Seq_HELA_Human1.18606442
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17678247
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15427581
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.14615486
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14157752
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13205130
47SOX2_21211035_ChIP-Seq_LN229_Human1.09707147
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09627116
49GATA1_22025678_ChIP-Seq_K562_Human1.08683265
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04886233
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04886233
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04740111
53BCOR_27268052_Chip-Seq_Bcells_Human1.03985588
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03089812
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03040410
56ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02446605
57CTCF_20526341_ChIP-Seq_ESCs_Human1.01038682
58PHF8_20622854_ChIP-Seq_HELA_Human1.00905824
59P68_20966046_ChIP-Seq_HELA_Human1.00897304
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00337274
61BCL6_27268052_Chip-Seq_Bcells_Human1.00225904
62TET1_21451524_ChIP-Seq_MESCs_Mouse0.99784948
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97478907
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96863101
65GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96512119
66DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93948105
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93811169
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92145939
69BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.91391870
70GATA2_19941826_ChIP-Seq_K562_Human0.90311335
71CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87552477
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85094115
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84840834
74CEBPB_22108803_ChIP-Seq_LS180_Human0.84491954
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.84356287
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84256424
77ERG_21242973_ChIP-ChIP_JURKAT_Human0.81422116
78TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80090882
79BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80020672
80RAC3_21632823_ChIP-Seq_H3396_Human0.79373171
81RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78865245
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78510879
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76805538
84SOX2_22085726_ChIP-Seq_NPCs_Mouse0.76631315
85RXR_22158963_ChIP-Seq_LIVER_Mouse0.76242985
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75855702
87P53_21459846_ChIP-Seq_SAOS-2_Human0.74175539
88FLI1_27457419_Chip-Seq_LIVER_Mouse0.73711513
89SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.73629246
90JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72602597
91MYB_26560356_Chip-Seq_TH2_Human0.72345130
92ERG_20517297_ChIP-Seq_VCAP_Human0.71406057
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70282091
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70134896
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.68586088
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.67807635
97OCT4_19829295_ChIP-Seq_ESCs_Human0.66825908
98NANOG_20526341_ChIP-Seq_ESCs_Human0.65382127
99IRF8_27001747_Chip-Seq_BMDM_Mouse0.63503887
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.62990865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.95212136
2MP0003806_abnormal_nucleotide_metabolis4.84006602
3MP0005464_abnormal_platelet_physiology4.67426280
4MP0009278_abnormal_bone_marrow4.60986534
5MP0003303_peritoneal_inflammation4.29806527
6MP0000569_abnormal_digit_pigmentation4.13564944
7MP0001545_abnormal_hematopoietic_system3.37725529
8MP0005397_hematopoietic_system_phenotyp3.37725529
9MP0004130_abnormal_muscle_cell3.18468360
10MP0008875_abnormal_xenobiotic_pharmacok3.01473406
11MP0005410_abnormal_fertilization2.72579123
12MP0003718_maternal_effect2.67523939
13MP0008004_abnormal_stomach_pH2.50339644
14MP0002653_abnormal_ependyma_morphology2.29218029
15MP0000465_gastrointestinal_hemorrhage1.98555296
16MP0003656_abnormal_erythrocyte_physiolo1.97407895
17MP0002332_abnormal_exercise_endurance1.96373726
18MP0004233_abnormal_muscle_weight1.95034880
19MP0003828_pulmonary_edema1.74410065
20MP0005645_abnormal_hypothalamus_physiol1.58180227
21MP0005083_abnormal_biliary_tract1.52518128
22MP0006036_abnormal_mitochondrial_physio1.51780943
23MP0002269_muscular_atrophy1.48684811
24MP0003436_decreased_susceptibility_to1.45857610
25MP0005058_abnormal_lysosome_morphology1.45394425
26MP0004742_abnormal_vestibular_system1.43595631
27MP0001533_abnormal_skeleton_physiology1.36511523
28MP0000230_abnormal_systemic_arterial1.36070932
29MP0009333_abnormal_splenocyte_physiolog1.35972476
30MP0005076_abnormal_cell_differentiation1.33981138
31MP0005084_abnormal_gallbladder_morpholo1.33663127
32MP0003191_abnormal_cellular_cholesterol1.33036919
33MP0001764_abnormal_homeostasis1.32684386
34MP0005266_abnormal_metabolism1.28230126
35MP0001501_abnormal_sleep_pattern1.25634716
36MP0005167_abnormal_blood-brain_barrier1.22908816
37MP0004036_abnormal_muscle_relaxation1.16834057
38MP0005174_abnormal_tail_pigmentation1.15557374
39MP0001835_abnormal_antigen_presentation1.13682134
40MP0001905_abnormal_dopamine_level1.13397537
41MP0005647_abnormal_sex_gland1.12247949
42MP0005376_homeostasis/metabolism_phenot1.08887492
43MP0002723_abnormal_immune_serum1.08809413
44MP0001664_abnormal_digestion1.05581020
45MP0000343_altered_response_to1.05247889
46MP0005408_hypopigmentation1.04876093
47MP0003959_abnormal_lean_body1.04009194
48MP0004084_abnormal_cardiac_muscle1.03752984
49MP0002971_abnormal_brown_adipose1.02488312
50MP0005000_abnormal_immune_tolerance1.01712526
51MP0003195_calcinosis1.00095064
52MP0009840_abnormal_foam_cell0.99452166
53MP0004510_myositis0.95561129
54MP0010329_abnormal_lipoprotein_level0.95175786
55MP0005448_abnormal_energy_balance0.94878475
56MP0009115_abnormal_fat_cell0.91484363
57MP0003638_abnormal_response/metabolism_0.91238394
58MP0004085_abnormal_heartbeat0.90298279
59MP0005025_abnormal_response_to0.89911951
60MP0002398_abnormal_bone_marrow0.89884439
61MP0002419_abnormal_innate_immunity0.89839985
62MP0001800_abnormal_humoral_immune0.87880197
63MP0002452_abnormal_antigen_presenting0.87122396
64MP0002429_abnormal_blood_cell0.87009871
65MP0001944_abnormal_pancreas_morphology0.85490338
66MP0010155_abnormal_intestine_physiology0.85365397
67MP0002132_abnormal_respiratory_system0.84217936
68MP0000716_abnormal_immune_system0.83858743
69MP0005595_abnormal_vascular_smooth0.81586638
70MP0000689_abnormal_spleen_morphology0.80345042
71MP0005334_abnormal_fat_pad0.78625778
72MP0005636_abnormal_mineral_homeostasis0.77880353
73MP0004947_skin_inflammation0.74547322
74MP0003186_abnormal_redox_activity0.74484556
75MP0000015_abnormal_ear_pigmentation0.74297627
76MP0002972_abnormal_cardiac_muscle0.73894535
77MP0001819_abnormal_immune_cell0.73288398
78MP0002420_abnormal_adaptive_immunity0.73170593
79MP0001845_abnormal_inflammatory_respons0.73165916
80MP0001663_abnormal_digestive_system0.71063972
81MP0006276_abnormal_autonomic_nervous0.69562319
82MP0001765_abnormal_ion_homeostasis0.69367317
83MP0005646_abnormal_pituitary_gland0.69268443
84MP0000703_abnormal_thymus_morphology0.69163618
85MP0003075_altered_response_to0.68178658
86MP0005390_skeleton_phenotype0.67994829
87MP0008260_abnormal_autophagy0.67113139
88MP0003698_abnormal_male_reproductive0.66329360
89MP0002736_abnormal_nociception_after0.65399699
90MP0001191_abnormal_skin_condition0.65018917
91MP0009642_abnormal_blood_homeostasis0.64900347
92MP0003879_abnormal_hair_cell0.64285248
93MP0009046_muscle_twitch0.63704373
94MP0006138_congestive_heart_failure0.63187375
95MP0002118_abnormal_lipid_homeostasis0.62739365
96MP0008775_abnormal_heart_ventricle0.62721938
97MP0000249_abnormal_blood_vessel0.62668214
98MP0001853_heart_inflammation0.62662971
99MP0002148_abnormal_hypersensitivity_rea0.62266463
100MP0005620_abnormal_muscle_contractility0.60967434

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)9.28155285
2Prolonged bleeding time (HP:0003010)5.73376399
3Abnormal number of erythroid precursors (HP:0012131)5.49701783
4Hyperthyroidism (HP:0000836)5.34088850
5Menorrhagia (HP:0000132)5.26964493
6Increased mean platelet volume (HP:0011877)5.23523198
7Petechiae (HP:0000967)5.01312610
8Seborrheic dermatitis (HP:0001051)4.99499956
9Decreased central vision (HP:0007663)4.95766367
10Abnormal platelet volume (HP:0011876)4.85133727
11Purpura (HP:0000979)4.65874182
12Abnormality of cells of the erythroid lineage (HP:0012130)4.57267652
13Absent rod-and cone-mediated responses on ERG (HP:0007688)4.56105156
14Hypochromic anemia (HP:0001931)4.43474934
15Epistaxis (HP:0000421)4.06311697
16Hypertensive crisis (HP:0100735)3.62959661
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.62866292
18Dicarboxylic aciduria (HP:0003215)3.62866292
19Progressive muscle weakness (HP:0003323)3.52581149
20Abnormal pupillary function (HP:0007686)3.45748334
21Obstructive lung disease (HP:0006536)3.39586607
22Chronic obstructive pulmonary disease (HP:0006510)3.39586607
23Abnormality of transition element cation homeostasis (HP:0011030)3.23304392
24Type 2 muscle fiber atrophy (HP:0003554)3.23064764
25Increased serum ferritin (HP:0003281)3.22481689
26Abnormality of iron homeostasis (HP:0011031)3.19531113
27Abnormal rod and cone electroretinograms (HP:0008323)3.11055399
28Foot dorsiflexor weakness (HP:0009027)3.10066947
29Cerebral edema (HP:0002181)3.09839946
30Stroke (HP:0001297)3.06555811
31Gingival bleeding (HP:0000225)2.97467722
32Severe visual impairment (HP:0001141)2.92954783
33Muscle fiber atrophy (HP:0100295)2.89006770
34Clumsiness (HP:0002312)2.86678659
35Attenuation of retinal blood vessels (HP:0007843)2.85122860
36Increased density of long bones (HP:0006392)2.78336094
37Abnormality of the foot musculature (HP:0001436)2.75552682
38Abnormal platelet function (HP:0011869)2.74840717
39Impaired platelet aggregation (HP:0003540)2.74840717
40Hyperlipoproteinemia (HP:0010980)2.74127214
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.74027347
42Truncus arteriosus (HP:0001660)2.72415950
43Upper limb muscle weakness (HP:0003484)2.70563948
44Pustule (HP:0200039)2.70002378
45Ketoacidosis (HP:0001993)2.52617176
46Flat capital femoral epiphysis (HP:0003370)2.50241938
47Spontaneous hematomas (HP:0007420)2.45361482
48Anomalous pulmonary venous return (HP:0010772)2.45318400
49Poikilocytosis (HP:0004447)2.43763984
50Eosinophilia (HP:0001880)2.42473704
51Bony spicule pigmentary retinopathy (HP:0007737)2.36612648
52Pigmentary retinal degeneration (HP:0001146)2.35125238
53Granulocytopenia (HP:0001913)2.33570629
54Abnormality of the prostate (HP:0008775)2.25820897
55Hammertoe (HP:0001765)2.25626612
56Hypoparathyroidism (HP:0000829)2.24116111
57Ketosis (HP:0001946)2.23092649
58Atelectasis (HP:0100750)2.20541218
59Nonprogressive disorder (HP:0003680)2.18566214
60Biliary tract neoplasm (HP:0100574)2.16982867
61Fatigable weakness (HP:0003473)2.15535524
62Abnormality of the neuromuscular junction (HP:0003398)2.15535524
63Increased IgM level (HP:0003496)2.14275254
64Abnormality of the tricuspid valve (HP:0001702)2.10522485
65Acanthocytosis (HP:0001927)2.10048448
66Abnormality of the pulmonary veins (HP:0011718)2.09160341
67Genetic anticipation (HP:0003743)2.09035969
68Microcytic anemia (HP:0001935)2.08079491
69Stomach cancer (HP:0012126)2.07811071
70Impaired vibratory sensation (HP:0002495)2.07402113
71Delayed puberty (HP:0000823)2.06740799
72Weak cry (HP:0001612)2.05823909
73Easy fatigability (HP:0003388)2.04607961
74Metabolic alkalosis (HP:0200114)2.03103006
75Decreased muscle mass (HP:0003199)2.00956187
76Abnormal ciliary motility (HP:0012262)2.00136805
77Exercise intolerance (HP:0003546)1.97182446
78Bruising susceptibility (HP:0000978)1.96472615
79Progressive cerebellar ataxia (HP:0002073)1.96252993
80Hypokalemic alkalosis (HP:0001949)1.96162177
81Fasciculations (HP:0002380)1.95318675
82Abnormal large intestine physiology (HP:0012700)1.92759770
83Hypocalcemia (HP:0002901)1.91592615
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90137240
85Macular degeneration (HP:0000608)1.87964955
86Autoimmune thrombocytopenia (HP:0001973)1.83714466
87Fair hair (HP:0002286)1.82641732
88Aplasia/Hypoplasia of the thymus (HP:0010515)1.80679881
89Generalized amyotrophy (HP:0003700)1.80329163
90Slender long bone (HP:0003100)1.79987233
91Bowel incontinence (HP:0002607)1.78800573
92Venous insufficiency (HP:0005293)1.78441313
93Dyschromatopsia (HP:0007641)1.76303910
94Absent/shortened dynein arms (HP:0200106)1.75556553
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.75556553
96Rimmed vacuoles (HP:0003805)1.73878140
97Pulmonary fibrosis (HP:0002206)1.73697136
98Right ventricular cardiomyopathy (HP:0011663)1.72456786
99Abnormality of lateral ventricle (HP:0030047)1.72430864
100Abnormality of eosinophils (HP:0001879)1.70790208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK8.09992079
2PTK2B4.96402221
3IKBKB3.15120418
4STK382.86412854
5MAP2K22.83589454
6LMTK22.61829484
7JAK32.35120949
8BMX2.31928144
9TXK2.27202829
10BTK2.18192412
11NME22.16143690
12RET2.11190394
13MAPK112.00224216
14TNK21.95547672
15PRKD21.89277242
16PINK11.89117465
17MARK31.87126403
18MYLK1.85393411
19BMPR21.73136413
20RPS6KC11.71654837
21RPS6KL11.71654837
22RIPK41.69358203
23RPS6KA61.67252575
24TEC1.64436228
25SYK1.48841265
26OBSCN1.46082512
27PIK3CG1.10805988
28MST41.09198972
29STK161.07439723
30TBK11.06098502
31BRSK21.05952493
32FLT31.03297980
33IKBKE1.01616594
34CAMKK20.98737281
35KDR0.97519385
36FRK0.97229766
37RPS6KA50.94690133
38DAPK20.87948658
39PHKG20.85292132
40PHKG10.85292132
41MATK0.85172214
42TESK20.85168318
43PAK10.81567314
44RPS6KA10.76916570
45PBK0.72770446
46MAP2K10.71882644
47LCK0.71295872
48RPS6KA20.70596531
49DYRK1A0.65078017
50CSF1R0.64674126
51ZAP700.63931857
52FYN0.63930401
53STK30.62611393
54GRK50.61127366
55JAK20.59673148
56LYN0.59555160
57MAPKAPK50.59005417
58MAP3K70.55547742
59ADRBK20.55207295
60FGR0.54430311
61PDK20.53030093
62AKT30.52748654
63PDK10.52685333
64CDK90.48796102
65MAPK40.48682286
66STK38L0.48023583
67ILK0.46480390
68BLK0.46447642
69MAPK30.46310318
70DAPK30.45800124
71ABL10.44557285
72MAPKAPK30.41152650
73TLK10.38631093
74PRKAA10.38402602
75PRKCQ0.37145031
76STK390.36454643
77MAPKAPK20.36071607
78MAPK120.35791913
79MAPK70.35499278
80MAP3K140.34464302
81MAPK10.34174442
82SRC0.33004506
83WNK40.31894771
84PDPK10.31037363
85INSR0.31037359
86GRK10.30902080
87AKT10.30361920
88CAMK10.30073277
89RPS6KA30.29381314
90GRK60.29181220
91DYRK30.28386584
92PRKD10.28260580
93SGK10.26742885
94PRKACG0.25866774
95MET0.25863128
96CSK0.25772978
97STK110.24818544
98ITK0.23612904
99NTRK10.22026675
100DYRK1B0.21848646

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.28588258
2Platelet activation_Homo sapiens_hsa046113.11398103
3Fatty acid elongation_Homo sapiens_hsa000622.83165375
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.72524504
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.40768993
6Asthma_Homo sapiens_hsa053102.38861664
7Nitrogen metabolism_Homo sapiens_hsa009102.36676273
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.33142242
9Linoleic acid metabolism_Homo sapiens_hsa005912.31136474
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24614200
11Olfactory transduction_Homo sapiens_hsa047402.15870131
12Graft-versus-host disease_Homo sapiens_hsa053322.07723421
13Pentose phosphate pathway_Homo sapiens_hsa000302.00700733
14Arachidonic acid metabolism_Homo sapiens_hsa005902.00547055
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.87099648
16Allograft rejection_Homo sapiens_hsa053301.82097555
17Autoimmune thyroid disease_Homo sapiens_hsa053201.74906898
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69033381
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.66742512
20Systemic lupus erythematosus_Homo sapiens_hsa053221.57465266
21Tyrosine metabolism_Homo sapiens_hsa003501.53400655
22Rheumatoid arthritis_Homo sapiens_hsa053231.52679788
23beta-Alanine metabolism_Homo sapiens_hsa004101.39525243
24Hematopoietic cell lineage_Homo sapiens_hsa046401.38716823
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.37840676
26Viral myocarditis_Homo sapiens_hsa054161.29407265
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28317170
28Glycerolipid metabolism_Homo sapiens_hsa005611.27816014
29Staphylococcus aureus infection_Homo sapiens_hsa051501.27623395
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23147341
31Phototransduction_Homo sapiens_hsa047441.19780733
32Type I diabetes mellitus_Homo sapiens_hsa049401.11252927
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08925773
34Chemical carcinogenesis_Homo sapiens_hsa052041.07123606
35Chemokine signaling pathway_Homo sapiens_hsa040621.04532517
36Ovarian steroidogenesis_Homo sapiens_hsa049131.03053323
37Regulation of autophagy_Homo sapiens_hsa041401.02867795
38mTOR signaling pathway_Homo sapiens_hsa041501.01031805
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00128925
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99454687
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.92842368
42Alcoholism_Homo sapiens_hsa050340.92514693
43Legionellosis_Homo sapiens_hsa051340.84455839
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.83816842
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77890957
46ABC transporters_Homo sapiens_hsa020100.74859549
47Peroxisome_Homo sapiens_hsa041460.74614373
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74349098
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73432634
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73390248
51Butanoate metabolism_Homo sapiens_hsa006500.70124044
52ECM-receptor interaction_Homo sapiens_hsa045120.69730391
53Primary immunodeficiency_Homo sapiens_hsa053400.67978529
54Leishmaniasis_Homo sapiens_hsa051400.67305517
55Non-small cell lung cancer_Homo sapiens_hsa052230.67159812
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.65937307
57Collecting duct acid secretion_Homo sapiens_hsa049660.65183954
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64044847
59Measles_Homo sapiens_hsa051620.63720747
60Serotonergic synapse_Homo sapiens_hsa047260.63451536
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63309466
62Caffeine metabolism_Homo sapiens_hsa002320.61949989
63Retinol metabolism_Homo sapiens_hsa008300.61277477
64B cell receptor signaling pathway_Homo sapiens_hsa046620.60912565
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59076721
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58630579
67Choline metabolism in cancer_Homo sapiens_hsa052310.58382055
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58283743
69Gap junction_Homo sapiens_hsa045400.57254724
70Tryptophan metabolism_Homo sapiens_hsa003800.56665503
71Purine metabolism_Homo sapiens_hsa002300.56443913
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56316149
73Morphine addiction_Homo sapiens_hsa050320.56062353
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55952817
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.53833048
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52582512
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.51530843
78Inositol phosphate metabolism_Homo sapiens_hsa005620.50063523
79Calcium signaling pathway_Homo sapiens_hsa040200.49749965
80Apoptosis_Homo sapiens_hsa042100.49499382
81Prolactin signaling pathway_Homo sapiens_hsa049170.48406020
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48200951
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48069665
84Renin secretion_Homo sapiens_hsa049240.47183655
85Antigen processing and presentation_Homo sapiens_hsa046120.46418988
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45996184
87Phagosome_Homo sapiens_hsa041450.42585941
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.40024382
89Mineral absorption_Homo sapiens_hsa049780.39676326
90Glutathione metabolism_Homo sapiens_hsa004800.39412840
91Starch and sucrose metabolism_Homo sapiens_hsa005000.39411600
92FoxO signaling pathway_Homo sapiens_hsa040680.38358389
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38224594
94Endocytosis_Homo sapiens_hsa041440.37665082
95Circadian entrainment_Homo sapiens_hsa047130.36673201
96Ether lipid metabolism_Homo sapiens_hsa005650.35850014
97Sulfur relay system_Homo sapiens_hsa041220.35133962
98Type II diabetes mellitus_Homo sapiens_hsa049300.35130803
99AMPK signaling pathway_Homo sapiens_hsa041520.34945053
100Histidine metabolism_Homo sapiens_hsa003400.34360814

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