FAM188B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.63683175
2motile cilium assembly (GO:0044458)9.53099151
3fusion of sperm to egg plasma membrane (GO:0007342)9.50652322
4sperm motility (GO:0030317)8.98120808
5cell wall macromolecule catabolic process (GO:0016998)8.75943615
6cell wall macromolecule metabolic process (GO:0044036)8.75943615
7sperm-egg recognition (GO:0035036)8.35656338
8acrosome assembly (GO:0001675)8.31388618
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.15600656
10acrosome reaction (GO:0007340)7.87781189
11multicellular organism reproduction (GO:0032504)7.77562315
12regulation of cilium movement (GO:0003352)7.68939010
13binding of sperm to zona pellucida (GO:0007339)7.65636974
14cell-cell recognition (GO:0009988)7.49286350
15piRNA metabolic process (GO:0034587)7.36634525
16plasma membrane fusion (GO:0045026)7.31837429
17spermatid development (GO:0007286)6.98268581
18male meiosis (GO:0007140)6.46673023
19reproduction (GO:0000003)6.46124319
20intraciliary transport (GO:0042073)6.42927926
21ventricular system development (GO:0021591)6.10798835
22axoneme assembly (GO:0035082)5.91904825
23synaptonemal complex organization (GO:0070193)5.75833531
24single fertilization (GO:0007338)5.63483751
25synaptonemal complex assembly (GO:0007130)5.41062188
26microtubule severing (GO:0051013)5.20310624
27negative regulation of inclusion body assembly (GO:0090084)4.98687704
28regulation of inclusion body assembly (GO:0090083)4.77669861
29protein localization to cilium (GO:0061512)4.75218526
30left/right axis specification (GO:0070986)4.74769431
31sperm capacitation (GO:0048240)4.70742434
32DNA methylation involved in gamete generation (GO:0043046)4.68734980
33spermatogenesis (GO:0007283)4.64870960
34male gamete generation (GO:0048232)4.62520007
35fertilization (GO:0009566)4.61534502
36cilium organization (GO:0044782)4.58814589
37aldehyde catabolic process (GO:0046185)4.51334776
38cilium assembly (GO:0042384)4.49751442
39cilium morphogenesis (GO:0060271)4.42751940
40left/right pattern formation (GO:0060972)4.40052163
41microtubule depolymerization (GO:0007019)4.27579229
42gamete generation (GO:0007276)4.24611828
43regulation of microtubule-based movement (GO:0060632)4.21016016
44organic cation transport (GO:0015695)4.14579607
45protein polyglutamylation (GO:0018095)4.01711893
46germ cell development (GO:0007281)4.01449678
47ubiquinone metabolic process (GO:0006743)3.94018303
48cellular process involved in reproduction in multicellular organism (GO:0022412)3.92796434
49male meiosis I (GO:0007141)3.91579452
50histone H2A acetylation (GO:0043968)3.90482233
51ubiquinone biosynthetic process (GO:0006744)3.86256766
52cell recognition (GO:0008037)3.83960214
53cellular component assembly involved in morphogenesis (GO:0010927)3.83412634
54meiotic nuclear division (GO:0007126)3.73029022
55nonmotile primary cilium assembly (GO:0035058)3.68880666
56chromosome organization involved in meiosis (GO:0070192)3.66047018
57calcium ion-dependent exocytosis (GO:0017156)3.65154423
58GTP biosynthetic process (GO:0006183)3.61868328
59nucleoside diphosphate phosphorylation (GO:0006165)3.52867055
60spermatid nucleus differentiation (GO:0007289)3.51993872
61lactate metabolic process (GO:0006089)3.51314860
62centriole assembly (GO:0098534)3.44979279
63retinal rod cell development (GO:0046548)3.43488810
64water-soluble vitamin biosynthetic process (GO:0042364)3.42863351
65microtubule-based movement (GO:0007018)3.42009896
66multicellular organismal reproductive process (GO:0048609)3.37129156
67chaperone-mediated protein complex assembly (GO:0051131)3.34803185
68photoreceptor cell maintenance (GO:0045494)3.29440538
69centriole replication (GO:0007099)3.19399294
70UTP biosynthetic process (GO:0006228)3.18295397
71meiosis I (GO:0007127)3.13050093
72mannosylation (GO:0097502)3.12699035
73DNA double-strand break processing (GO:0000729)3.10213118
74cornea development in camera-type eye (GO:0061303)3.08263960
75quinone biosynthetic process (GO:1901663)3.02945014
76microtubule bundle formation (GO:0001578)3.01369894
77microtubule polymerization or depolymerization (GO:0031109)3.00762365
78meiotic cell cycle (GO:0051321)2.99041780
79vitamin transmembrane transport (GO:0035461)2.96012998
80UTP metabolic process (GO:0046051)2.95565218
81retinal cone cell development (GO:0046549)2.93702950
82one-carbon compound transport (GO:0019755)2.90183417
83gene silencing by RNA (GO:0031047)2.89703456
84smoothened signaling pathway (GO:0007224)2.83764058
85eye photoreceptor cell differentiation (GO:0001754)2.83303458
86photoreceptor cell differentiation (GO:0046530)2.83303458
87dopamine transport (GO:0015872)2.81156052
88multicellular organismal development (GO:0007275)2.80725184
89behavioral response to nicotine (GO:0035095)2.79543624
90positive regulation of macrophage activation (GO:0043032)2.79228323
91cell projection assembly (GO:0030031)2.78548258
92reciprocal meiotic recombination (GO:0007131)2.76917063
93reciprocal DNA recombination (GO:0035825)2.76917063
94neuron projection extension involved in neuron projection guidance (GO:1902284)2.74222086
95axon extension involved in axon guidance (GO:0048846)2.74222086
96guanosine-containing compound biosynthetic process (GO:1901070)2.70184261
97intra-S DNA damage checkpoint (GO:0031573)2.69909763
98lateral ventricle development (GO:0021670)2.69433785
99diterpenoid biosynthetic process (GO:0016102)2.66039791
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.65033444
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.65033444
102UDP-N-acetylglucosamine metabolic process (GO:0006047)2.63975948
103seminiferous tubule development (GO:0072520)2.63306798
104regulation of meiosis I (GO:0060631)2.62833661
105genitalia morphogenesis (GO:0035112)2.61194269
106protein refolding (GO:0042026)2.60438778
107photoreceptor cell development (GO:0042461)2.59929658
108determination of left/right symmetry (GO:0007368)2.59462940
109resolution of meiotic recombination intermediates (GO:0000712)2.57404160
110determination of bilateral symmetry (GO:0009855)2.51738795
111glycerol ether metabolic process (GO:0006662)2.50138429
112synapsis (GO:0007129)2.48023566
113meiotic chromosome segregation (GO:0045132)2.47581967
114replication fork processing (GO:0031297)2.47567896
115peptidyl-glutamic acid modification (GO:0018200)2.47308613
116sex differentiation (GO:0007548)2.45383222
117specification of symmetry (GO:0009799)2.45182598
118cell migration involved in heart development (GO:0060973)2.43322457
119peptidyl-histidine modification (GO:0018202)2.42444608
120glyoxylate metabolic process (GO:0046487)2.41826727
121terpenoid biosynthetic process (GO:0016114)2.40737234
122single strand break repair (GO:0000012)2.40404568
123CTP metabolic process (GO:0046036)2.40071014
124CTP biosynthetic process (GO:0006241)2.40071014
125heart looping (GO:0001947)2.39879445
126chromosome condensation (GO:0030261)2.39673989
127translesion synthesis (GO:0019985)2.35971960
128L-ascorbic acid metabolic process (GO:0019852)2.35717241
129DNA packaging (GO:0006323)2.35281746
130regulation of cytokine production involved in inflammatory response (GO:1900015)2.35078173
131eye photoreceptor cell development (GO:0042462)2.34785343
132positive regulation of smoothened signaling pathway (GO:0045880)2.33894442
133brain morphogenesis (GO:0048854)2.33412166
134positive regulation of meiosis (GO:0045836)2.32493582
135pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.30160532
136regulation of glucocorticoid secretion (GO:2000849)2.29790683
137exogenous drug catabolic process (GO:0042738)2.28191092
138cellular ketone body metabolic process (GO:0046950)2.28015135
139limb development (GO:0060173)2.27961760
140appendage development (GO:0048736)2.27961760
141protein complex biogenesis (GO:0070271)2.27483582
142sensory perception of smell (GO:0007608)2.26730195
143glutathione derivative metabolic process (GO:1901685)2.25427029
144glutathione derivative biosynthetic process (GO:1901687)2.25427029
145double-strand break repair via homologous recombination (GO:0000724)2.25395402
146recombinational repair (GO:0000725)2.23750103
147preassembly of GPI anchor in ER membrane (GO:0016254)2.23410136
148mitochondrial respiratory chain complex assembly (GO:0033108)2.22728775
149respiratory chain complex IV assembly (GO:0008535)2.22421778
150negative regulation of T cell differentiation in thymus (GO:0033085)2.20989011
151indolalkylamine metabolic process (GO:0006586)2.20668751
152quinone metabolic process (GO:1901661)2.20591651
153organelle assembly (GO:0070925)2.19451710
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.17916533
155drug catabolic process (GO:0042737)2.15678268
156positive regulation of meiotic cell cycle (GO:0051446)2.14670495
157cilium or flagellum-dependent cell motility (GO:0001539)12.5518943
158axonemal dynein complex assembly (GO:0070286)11.6092978
159cilium movement (GO:0003341)10.2720753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.06887000
2EZH2_22144423_ChIP-Seq_EOC_Human4.83251173
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.53493619
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32976163
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.28088597
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86643236
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.75917134
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71001737
9ZNF274_21170338_ChIP-Seq_K562_Hela2.65702424
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39221114
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35345270
12TAF15_26573619_Chip-Seq_HEK293_Human2.22622632
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.21698402
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.03617145
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.99672072
16EWS_26573619_Chip-Seq_HEK293_Human1.94401114
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.93869727
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.92444773
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92007862
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88297396
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85694208
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84278404
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76171609
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.74225296
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68033040
26TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67499485
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63821876
28ER_23166858_ChIP-Seq_MCF-7_Human1.63569208
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60530699
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59787504
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.59199674
32* STAT3_23295773_ChIP-Seq_U87_Human1.55837081
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53745678
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53342661
35CBP_20019798_ChIP-Seq_JUKART_Human1.53342661
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51199412
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50930779
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.50079215
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49896294
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.49889702
41* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49236728
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46098108
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46072670
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43919367
45* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43516251
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40163772
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39461260
48KDM2B_26808549_Chip-Seq_REH_Human1.38882346
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38559969
50STAT1_17558387_ChIP-Seq_HELA_Human1.38161982
51PHF8_20622853_ChIP-Seq_HELA_Human1.36745526
52GBX2_23144817_ChIP-Seq_PC3_Human1.35937233
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.33812035
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32857536
55* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32285118
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.31068862
57TCF4_22108803_ChIP-Seq_LS180_Human1.29669627
58IRF1_19129219_ChIP-ChIP_H3396_Human1.29462723
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28059160
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.27285527
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27181550
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.27181550
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26608782
64VDR_22108803_ChIP-Seq_LS180_Human1.25614541
65* RUNX2_22187159_ChIP-Seq_PCA_Human1.25580654
66RNF2_27304074_Chip-Seq_NSC_Mouse1.24602364
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24298179
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23084921
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.22976721
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21344319
71NFYB_21822215_ChIP-Seq_K562_Human1.20848173
72ETV1_20927104_ChIP-Seq_GIST48_Human1.19360876
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19158477
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18048608
75RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17967714
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16708432
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.16614021
78MYC_18940864_ChIP-ChIP_HL60_Human1.16145932
79GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15344896
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15009235
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14760826
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14760826
83GATA3_21867929_ChIP-Seq_CD8_Mouse1.14246923
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13187825
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13120279
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13102148
87SOX2_19829295_ChIP-Seq_ESCs_Human1.12707705
88NANOG_19829295_ChIP-Seq_ESCs_Human1.12707705
89AR_20517297_ChIP-Seq_VCAP_Human1.12473089
90ELK1_19687146_ChIP-ChIP_HELA_Human1.11636648
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11341872
92HOXB7_26014856_ChIP-Seq_BT474_Human1.11301534
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11132143
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10836973
95TP53_22573176_ChIP-Seq_HFKS_Human1.10778958
96LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10594373
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10472120
98KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10288573
99REST_21632747_ChIP-Seq_MESCs_Mouse1.09465569
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09438041
101TBL1_22424771_ChIP-Seq_293T_Human1.09434092
102SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09424077
103AHR_22903824_ChIP-Seq_MCF-7_Human1.08808799
104HNFA_21074721_ChIP-Seq_CACO-2_Human1.08673848
105NFYA_21822215_ChIP-Seq_K562_Human1.08568583
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07634765
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.07145537
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06969940
109P53_21459846_ChIP-Seq_SAOS-2_Human1.06008917
110RBPJ_21746931_ChIP-Seq_IB4_Human1.05369754
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.04602908
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04360845
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04250149
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02779946
115ERG_20517297_ChIP-Seq_VCAP_Human1.02760985
116LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02149286
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.01583110
118SMAD4_21799915_ChIP-Seq_A2780_Human1.00879529
119CDX2_22108803_ChIP-Seq_LS180_Human1.00842781
120GATA3_21878914_ChIP-Seq_MCF-7_Human1.00747792
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.00709580
122P53_22387025_ChIP-Seq_ESCs_Mouse1.00626515
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00406196
124RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00272894
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99910166
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99820452
127CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98275431
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.97359496
129GATA6_21074721_ChIP-Seq_CACO-2_Human0.97236888
130AR_25329375_ChIP-Seq_VCAP_Human0.96849434
131EZH2_27294783_Chip-Seq_ESCs_Mouse0.94924185
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93773772
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93042497
134BCAT_22108803_ChIP-Seq_LS180_Human0.92684582
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92616161
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92417763
137IGF1R_20145208_ChIP-Seq_DFB_Human0.92310158
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.92245816
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91028799
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91014739
141P300_18555785_Chip-Seq_ESCs_Mouse0.90518864
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90497421
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.90259240
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.89826537
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89731598
146GF1_26923725_Chip-Seq_HPCs_Mouse0.89256343
147P300_19829295_ChIP-Seq_ESCs_Human0.89243251
148TCF4_23295773_ChIP-Seq_U87_Human0.88974373
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.88972079
150* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88886215
151FUS_26573619_Chip-Seq_HEK293_Human0.88746888
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88101202
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87998882
154CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87504146
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87219313
156SOX9_26525672_Chip-Seq_HEART_Mouse0.85636825
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.85102453
158LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84142334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.89640324
2MP0003698_abnormal_male_reproductive4.11952042
3MP0008877_abnormal_DNA_methylation3.96809104
4MP0001929_abnormal_gametogenesis3.85344125
5MP0008875_abnormal_xenobiotic_pharmacok3.33738796
6MP0005670_abnormal_white_adipose2.82924467
7MP0002638_abnormal_pupillary_reflex2.79969663
8MP0002210_abnormal_sex_determination2.72257464
9MP0002160_abnormal_reproductive_system2.63456288
10MP0004133_heterotaxia2.59674209
11MP0009780_abnormal_chondrocyte_physiolo2.41191497
12MP0000372_irregular_coat_pigmentation2.40020023
13MP0009046_muscle_twitch2.28893077
14MP0002653_abnormal_ependyma_morphology2.28075173
15MP0002161_abnormal_fertility/fecundity2.22288861
16MP0009697_abnormal_copulation2.20829567
17MP0001145_abnormal_male_reproductive2.16707001
18MP0005503_abnormal_tendon_morphology2.02727426
19MP0003718_maternal_effect2.01614906
20MP0005623_abnormal_meninges_morphology2.00555729
21MP0000653_abnormal_sex_gland1.98249734
22MP0008789_abnormal_olfactory_epithelium1.95711898
23MP0005171_absent_coat_pigmentation1.92558046
24MP0005647_abnormal_sex_gland1.81636521
25MP0004043_abnormal_pH_regulation1.81220899
26MP0002282_abnormal_trachea_morphology1.80951817
27MP0000383_abnormal_hair_follicle1.79693109
28MP0008995_early_reproductive_senescence1.76939778
29MP0000631_abnormal_neuroendocrine_gland1.69033035
30MP0002234_abnormal_pharynx_morphology1.67820077
31MP0005389_reproductive_system_phenotype1.65411488
32MP0005646_abnormal_pituitary_gland1.63684998
33MP0008057_abnormal_DNA_replication1.61106472
34MP0005499_abnormal_olfactory_system1.56025230
35MP0005394_taste/olfaction_phenotype1.56025230
36MP0003136_yellow_coat_color1.56022431
37MP0001485_abnormal_pinna_reflex1.54175613
38MP0002254_reproductive_system_inflammat1.52426339
39MP0010030_abnormal_orbit_morphology1.52347451
40MP0003942_abnormal_urinary_system1.51571427
41MP0006054_spinal_hemorrhage1.51091162
42MP0001968_abnormal_touch/_nociception1.46557176
43MP0001984_abnormal_olfaction1.40745397
44MP0003786_premature_aging1.36591965
45MP0005645_abnormal_hypothalamus_physiol1.36250205
46MP0006276_abnormal_autonomic_nervous1.35984570
47MP0002938_white_spotting1.32047030
48MP0000049_abnormal_middle_ear1.31583486
49MP0005395_other_phenotype1.27872355
50MP0010678_abnormal_skin_adnexa1.27767059
51MP0008872_abnormal_physiological_respon1.27473165
52MP0004858_abnormal_nervous_system1.27279444
53MP0002928_abnormal_bile_duct1.23710438
54MP0002736_abnormal_nociception_after1.21915082
55MP0001502_abnormal_circadian_rhythm1.19380874
56MP0001764_abnormal_homeostasis1.19097523
57MP0002108_abnormal_muscle_morphology1.19040321
58MP0008058_abnormal_DNA_repair1.17926280
59MP0004147_increased_porphyrin_level1.15707248
60MP0001501_abnormal_sleep_pattern1.15679687
61MP0003279_aneurysm1.14064495
62MP0008007_abnormal_cellular_replicative1.13531875
63MP0010386_abnormal_urinary_bladder1.12874987
64MP0000569_abnormal_digit_pigmentation1.12603227
65MP0001944_abnormal_pancreas_morphology1.11156614
66MP0005187_abnormal_penis_morphology1.08902997
67MP0005551_abnormal_eye_electrophysiolog1.07482381
68MP0003283_abnormal_digestive_organ1.06648775
69MP0001324_abnormal_eye_pigmentation1.05263200
70MP0003011_delayed_dark_adaptation1.05226970
71MP0008438_abnormal_cutaneous_collagen1.00991781
72MP0000647_abnormal_sebaceous_gland1.00343212
73MP0003195_calcinosis0.99578054
74MP0002909_abnormal_adrenal_gland0.98041845
75MP0002168_other_aberrant_phenotype0.97392853
76MP0005083_abnormal_biliary_tract0.97155516
77MP0009745_abnormal_behavioral_response0.96723684
78MP0000566_synostosis0.95902212
79MP0002557_abnormal_social/conspecific_i0.92608270
80MP0003186_abnormal_redox_activity0.92135808
81MP0004019_abnormal_vitamin_homeostasis0.92026197
82MP0001346_abnormal_lacrimal_gland0.91952800
83MP0001270_distended_abdomen0.91724145
84MP0004215_abnormal_myocardial_fiber0.91185482
85MP0001299_abnormal_eye_distance/0.91132421
86MP0000751_myopathy0.90782823
87MP0003137_abnormal_impulse_conducting0.87733630
88MP0003252_abnormal_bile_duct0.87482459
89MP0002249_abnormal_larynx_morphology0.87478600
90MP0002837_dystrophic_cardiac_calcinosis0.86916268
91MP0003115_abnormal_respiratory_system0.86305576
92MP0002075_abnormal_coat/hair_pigmentati0.86109985
93MP0009384_cardiac_valve_regurgitation0.85646395
94MP0004270_analgesia0.85574414
95MP0002139_abnormal_hepatobiliary_system0.85335567
96MP0004272_abnormal_basement_membrane0.85319757
97MP0004085_abnormal_heartbeat0.84993969
98MP0002272_abnormal_nervous_system0.83177456
99MP0005084_abnormal_gallbladder_morpholo0.82511892
100MP0004233_abnormal_muscle_weight0.82248977
101MP0000534_abnormal_ureter_morphology0.81568885
102MP0006292_abnormal_olfactory_placode0.81294796
103MP0002269_muscular_atrophy0.81252037
104MP0004145_abnormal_muscle_electrophysio0.80884147
105MP0002229_neurodegeneration0.80660429
106MP0009250_abnormal_appendicular_skeleto0.80506951
107MP0006072_abnormal_retinal_apoptosis0.80120727
108MP0003119_abnormal_digestive_system0.79826892
109MP0001529_abnormal_vocalization0.78696884
110MP0003890_abnormal_embryonic-extraembry0.78633356
111MP0002127_abnormal_cardiovascular_syste0.78298386
112MP0001486_abnormal_startle_reflex0.75728139
113MP0006036_abnormal_mitochondrial_physio0.75663807
114MP0002233_abnormal_nose_morphology0.75539778
115MP0000026_abnormal_inner_ear0.75476781
116MP0002572_abnormal_emotion/affect_behav0.75310666
117MP0002734_abnormal_mechanical_nocicepti0.74945681
118MP0001963_abnormal_hearing_physiology0.74483578
119MP0008004_abnormal_stomach_pH0.72721741
120MP0001177_atelectasis0.72572039
121MP0000749_muscle_degeneration0.72434634
122MP0002877_abnormal_melanocyte_morpholog0.71954474
123MP0002102_abnormal_ear_morphology0.71492435
124MP0002116_abnormal_craniofacial_bone0.71430602
125MP0001293_anophthalmia0.70850856
126MP0001119_abnormal_female_reproductive0.70102909
127MP0003943_abnormal_hepatobiliary_system0.69976965
128MP0001986_abnormal_taste_sensitivity0.69884533
129MP0002295_abnormal_pulmonary_circulatio0.69429729
130MP0001919_abnormal_reproductive_system0.69039522
131MP0005253_abnormal_eye_physiology0.68271253
132MP0002095_abnormal_skin_pigmentation0.67562220
133MP0005508_abnormal_skeleton_morphology0.67105746
134MP0010094_abnormal_chromosome_stability0.65706918
135MP0002109_abnormal_limb_morphology0.65391377
136MP0003950_abnormal_plasma_membrane0.62945354
137MP0002115_abnormal_skeleton_extremities0.61756982
138MP0005391_vision/eye_phenotype0.61350983
139MP0001958_emphysema0.60707052
140MP0005220_abnormal_exocrine_pancreas0.60313517
141MP0005195_abnormal_posterior_eye0.59787822
142MP0002896_abnormal_bone_mineralization0.58964915
143MP0001873_stomach_inflammation0.57852383
144MP0005377_hearing/vestibular/ear_phenot0.57797713
145MP0003878_abnormal_ear_physiology0.57797713
146MP0003937_abnormal_limbs/digits/tail_de0.56902734
147MP0002876_abnormal_thyroid_physiology0.56544974
148MP0000462_abnormal_digestive_system0.56472983
149MP0000427_abnormal_hair_cycle0.56303757
150MP0000015_abnormal_ear_pigmentation0.55144336
151MP0005365_abnormal_bile_salt0.54577299
152MP0000371_diluted_coat_color0.54552519
153MP0000163_abnormal_cartilage_morphology0.53459431
154MP0002177_abnormal_outer_ear0.52711271
155MP0003385_abnormal_body_wall0.52379188
156MP0001765_abnormal_ion_homeostasis0.52049799

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.36976636
2Absent/shortened dynein arms (HP:0200106)9.14856890
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.14856890
4Abnormal ciliary motility (HP:0012262)8.07380007
5Abnormal respiratory motile cilium morphology (HP:0005938)7.99759748
6Abnormal respiratory epithelium morphology (HP:0012253)7.99759748
7Rhinitis (HP:0012384)7.46427786
8Chronic bronchitis (HP:0004469)6.27415898
9Infertility (HP:0000789)4.94688542
10Nasal polyposis (HP:0100582)4.29518374
11Bronchiectasis (HP:0002110)4.17240966
12Nephronophthisis (HP:0000090)3.99805893
13Abnormality of the nasal mucosa (HP:0000433)3.92284676
14Medial flaring of the eyebrow (HP:0010747)3.78878239
15Male infertility (HP:0003251)3.52542458
16Occipital encephalocele (HP:0002085)3.51830438
17Pancreatic fibrosis (HP:0100732)3.42695437
18Abnormality of dentin (HP:0010299)3.40005967
19True hermaphroditism (HP:0010459)3.38763673
20Congenital primary aphakia (HP:0007707)3.34258610
21Gait imbalance (HP:0002141)3.28183314
22Tubulointerstitial nephritis (HP:0001970)3.25399531
23Abnormality of midbrain morphology (HP:0002418)3.20067605
24Molar tooth sign on MRI (HP:0002419)3.20067605
25Abnormality of the renal medulla (HP:0100957)3.10247774
26Nephrogenic diabetes insipidus (HP:0009806)3.04185211
27Congenital hepatic fibrosis (HP:0002612)3.01285837
28Bronchitis (HP:0012387)2.97693088
29Postaxial foot polydactyly (HP:0001830)2.85718113
30Cystic liver disease (HP:0006706)2.81616126
31Facial cleft (HP:0002006)2.80486015
32Poor coordination (HP:0002370)2.74841116
33Type II lissencephaly (HP:0007260)2.65934536
34Supernumerary spleens (HP:0009799)2.65472998
35Decreased circulating renin level (HP:0003351)2.52025606
36Median cleft lip (HP:0000161)2.49438355
37Vaginal atresia (HP:0000148)2.46006183
38Pancreatic cysts (HP:0001737)2.42870824
39Postaxial hand polydactyly (HP:0001162)2.42571221
40Genital tract atresia (HP:0001827)2.41972216
41Chronic hepatic failure (HP:0100626)2.41811372
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.41084925
43Tubulointerstitial abnormality (HP:0001969)2.39528402
44Fibular hypoplasia (HP:0003038)2.34654177
45Bell-shaped thorax (HP:0001591)2.34409798
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.31575137
47Abnormality of the dental root (HP:0006486)2.22179675
48Taurodontia (HP:0000679)2.22179675
49Abnormality of permanent molar morphology (HP:0011071)2.22179675
50Bile duct proliferation (HP:0001408)2.20438615
51Abnormal biliary tract physiology (HP:0012439)2.20438615
52Abnormality of molar morphology (HP:0011070)2.15931064
53Abnormality of molar (HP:0011077)2.15931064
54Cerebellar dysplasia (HP:0007033)2.14605042
55Aplasia/Hypoplasia of the lens (HP:0008063)2.11549921
56Stage 5 chronic kidney disease (HP:0003774)2.11199931
57Atelectasis (HP:0100750)2.09910086
58Short nail (HP:0001799)2.06590880
59Cone-rod dystrophy (HP:0000548)2.05933204
60Abnormality of the dental pulp (HP:0006479)2.01509171
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.9939002
62Furrowed tongue (HP:0000221)1.97430215
63Aganglionic megacolon (HP:0002251)1.97051335
64Tubular atrophy (HP:0000092)1.96897549
65Short ribs (HP:0000773)1.96329925
66Recurrent otitis media (HP:0000403)1.93787241
67Oculomotor apraxia (HP:0000657)1.91052780
68Prominent nasal bridge (HP:0000426)1.89629960
69Chronic sinusitis (HP:0011109)1.86758563
70Aplasia/Hypoplasia of the fibula (HP:0006492)1.85670334
71Broad foot (HP:0001769)1.80673655
72Attenuation of retinal blood vessels (HP:0007843)1.79852957
73Hyperactive renin-angiotensin system (HP:0000841)1.79572500
74Abnormal rod and cone electroretinograms (HP:0008323)1.76810056
75Sclerocornea (HP:0000647)1.74914724
76Gaze-evoked nystagmus (HP:0000640)1.74788792
77Dyschromatopsia (HP:0007641)1.73174197
78Preaxial hand polydactyly (HP:0001177)1.72477089
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.71030988
80Male pseudohermaphroditism (HP:0000037)1.70063414
81Renal dysplasia (HP:0000110)1.68724918
82Widely spaced teeth (HP:0000687)1.68296459
83Highly arched eyebrow (HP:0002553)1.68262589
84Enlarged kidneys (HP:0000105)1.68161504
85Short thorax (HP:0010306)1.67574107
86Polydipsia (HP:0001959)1.67571191
87Abnormal drinking behavior (HP:0030082)1.67571191
88Tubulointerstitial fibrosis (HP:0005576)1.67287374
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.66649147
90Broad distal phalanx of finger (HP:0009836)1.66430282
91Anencephaly (HP:0002323)1.65521123
92Central scotoma (HP:0000603)1.63190445
93Astigmatism (HP:0000483)1.62672388
94Recurrent sinusitis (HP:0011108)1.61733871
95Abnormality of the renal cortex (HP:0011035)1.61012648
96Absent speech (HP:0001344)1.60767435
97Abolished electroretinogram (ERG) (HP:0000550)1.59588702
98Multicystic kidney dysplasia (HP:0000003)1.58596334
99Bifid tongue (HP:0010297)1.58404391
100Polycystic kidney dysplasia (HP:0000113)1.57017863
101Retinitis pigmentosa (HP:0000510)1.56876699
102Mesangial abnormality (HP:0001966)1.56505497
103Decreased central vision (HP:0007663)1.55974806
104Left ventricular hypertrophy (HP:0001712)1.55223249
105Retinal dysplasia (HP:0007973)1.52288878
106Narrow forehead (HP:0000341)1.52208956
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.52089739
108Absent frontal sinuses (HP:0002688)1.52054006
109Hypothermia (HP:0002045)1.51775588
110Abnormality of the labia minora (HP:0012880)1.51157303
111Abnormality of abdominal situs (HP:0011620)1.49932367
112Abdominal situs inversus (HP:0003363)1.49932367
113Absent thumb (HP:0009777)1.49929166
114Hypoplastic labia majora (HP:0000059)1.48881813
115Abnormal spermatogenesis (HP:0008669)1.48443946
116Polycystic ovaries (HP:0000147)1.47868519
117Hepatocellular necrosis (HP:0001404)1.47464789
118Sloping forehead (HP:0000340)1.46502859
119Hypodontia (HP:0000668)1.46438199
120Aplasia/Hypoplasia affecting the retina (HP:0008061)1.46366358
121Aplasia/hypoplasia of the uterus (HP:0008684)1.45744232
122Aplasia/Hypoplasia of the macula (HP:0008059)1.45662316
123Disproportionate short-trunk short stature (HP:0003521)1.44961670
124Decreased testicular size (HP:0008734)1.44813566
125Dandy-Walker malformation (HP:0001305)1.44464450
126Short tibia (HP:0005736)1.43750128
127Abnormality of renin-angiotensin system (HP:0000847)1.43693051
128Broad-based gait (HP:0002136)1.43691201
129Constricted visual fields (HP:0001133)1.43540462
130Gonadotropin excess (HP:0000837)1.42907474
131Lissencephaly (HP:0001339)1.42626128
132Asplenia (HP:0001746)1.41345967
13311 pairs of ribs (HP:0000878)1.40521430
134Narrow chest (HP:0000774)1.40222154
135Abnormality of the lower motor neuron (HP:0002366)1.38701419
136Hyperventilation (HP:0002883)1.34200018
137Neonatal short-limb short stature (HP:0008921)1.33768958
138Bony spicule pigmentary retinopathy (HP:0007737)1.33394291
139Dental crowding (HP:0000678)1.32623108
140Back pain (HP:0003418)1.32124649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.46030812
2PDK46.46030812
3FRK4.36707102
4TESK14.09078600
5PDK23.82034895
6MAPK153.49136885
7PRKD33.32903107
8MAP4K23.27256833
9MST43.11714010
10TNIK2.74349900
11PTK2B2.67039065
12ICK2.38479918
13MKNK22.31131731
14BRSK21.95261437
15STK161.89307673
16NME11.75196860
17PLK41.70551143
18NUAK11.70250275
19LMTK21.68835648
20CSNK1G31.65918344
21WNK41.61871729
22EPHA21.60903869
23CSNK1G11.59421518
24CSNK1G21.49840891
25TTK1.46532536
26ACVR1B1.44812918
27MKNK11.35753939
28BRAF1.32087733
29ZAK1.31419473
30ADRBK21.29021225
31IRAK11.22409751
32VRK11.22120849
33DYRK31.19938331
34PRKG21.19887438
35CDK81.17607855
36MAP2K71.16261619
37TIE11.15655466
38KIT1.14740478
39DDR21.12381478
40PIK3CG1.11679847
41EIF2AK11.11506954
42STK38L1.10607668
43PASK1.09398430
44SIK31.07650993
45PLK31.07255694
46CCNB11.05113200
47ERBB31.03985349
48PLK11.03676554
49CDC42BPA1.03432560
50DYRK1B1.02925684
51ARAF1.00639875
52WEE11.00568888
53FGFR20.97262583
54OXSR10.96331209
55LATS10.96067708
56TGFBR20.94810120
57CDC70.94800707
58SGK20.94293956
59MAPKAPK30.90485386
60RIPK10.88934202
61INSRR0.88433009
62MYLK0.88108702
63STK380.87820000
64BUB10.87167859
65MUSK0.87157640
66TGFBR10.85144979
67NTRK30.83090858
68MAPK130.82812092
69PINK10.81445204
70TRIM280.80389876
71SGK2230.78925566
72SGK4940.78925566
73MET0.77742487
74BMPR1B0.76765859
75TLK10.76297076
76NTRK20.76022529
77CSNK1A1L0.74716428
78MAPKAPK50.73901004
79PNCK0.70793283
80TRPM70.69053252
81EEF2K0.68325566
82PRKCG0.67032132
83PHKG20.65488679
84PHKG10.65488679
85TRIB30.64602457
86ATR0.63205637
87PAK30.62630768
88PRKCI0.62441684
89MAP3K60.62009739
90PRKAA10.61751923
91GRK10.60517641
92ATM0.60202977
93CDK120.59897749
94FLT30.59330300
95SGK30.59069954
96RPS6KA50.58016395
97PAK20.56382972
98STK390.55657338
99CDK30.54968246
100PBK0.54222688
101EIF2AK30.53520463
102MAP3K120.51303353
103DYRK20.51183486
104AURKA0.49642066
105CHEK20.48929229
106CSNK1A10.47617666
107EPHA30.47602308
108ADRBK10.47542731
109AKT30.47007026
110FER0.46956864
111NEK20.45424202
112MAP3K30.44669259
113TSSK60.44043300
114PDK10.43507565
115PRKAA20.42857117
116LATS20.40634989
117CAMK2A0.40331397
118CASK0.38857680
119EPHB20.38832958
120WNK30.38794171
121CSNK1E0.38097945
122RPS6KB10.36164499
123PLK20.35937651
124MINK10.35899230
125BCR0.34932537
126SIK10.34445306
127MAP3K40.33808719
128STK30.33507354
129PRKACA0.33446371
130AURKB0.33271634
131SRPK10.32180386
132BRD40.32035914
133RPS6KA20.30675058
134RET0.30261612
135EPHA40.30076084
136NEK10.30013235
137CSNK1D0.29311546
138CAMK2D0.29308410
139SCYL20.25959311
140PRKD20.25566093
141OBSCN0.25289256
142PRKCE0.25055865
143BCKDK0.25018097
144CDK90.24867418
145MST1R0.24744691
146PDPK10.21811492
147MTOR0.21359468
148BRSK10.20728850
149ROCK10.20588033
150PRKACB0.20576596
151KSR10.19717432
152MOS0.18307296
153BMPR20.17765101
154PAK10.17442104

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.54712158
2Pyruvate metabolism_Homo sapiens_hsa006203.30707509
3Selenocompound metabolism_Homo sapiens_hsa004503.22355293
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.95953018
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.73991372
6Fatty acid biosynthesis_Homo sapiens_hsa000612.69435360
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54932269
8Glucagon signaling pathway_Homo sapiens_hsa049222.18185379
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13544420
10Fatty acid degradation_Homo sapiens_hsa000712.12987804
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05778015
12Fatty acid metabolism_Homo sapiens_hsa012122.01037702
13Nitrogen metabolism_Homo sapiens_hsa009101.96434758
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94211555
15RNA polymerase_Homo sapiens_hsa030201.88758307
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.83855998
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80078887
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79867553
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79357071
20PPAR signaling pathway_Homo sapiens_hsa033201.76345700
21Caffeine metabolism_Homo sapiens_hsa002321.73971727
22Linoleic acid metabolism_Homo sapiens_hsa005911.70106840
23Proteasome_Homo sapiens_hsa030501.68871574
24Vitamin B6 metabolism_Homo sapiens_hsa007501.67982075
25Huntingtons disease_Homo sapiens_hsa050161.61115647
26Fanconi anemia pathway_Homo sapiens_hsa034601.60741261
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46252363
28beta-Alanine metabolism_Homo sapiens_hsa004101.45745060
29Circadian rhythm_Homo sapiens_hsa047101.43685807
30Amphetamine addiction_Homo sapiens_hsa050311.42766103
31Sulfur metabolism_Homo sapiens_hsa009201.40370251
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40024986
33Protein export_Homo sapiens_hsa030601.39644404
34Purine metabolism_Homo sapiens_hsa002301.37938690
35Phenylalanine metabolism_Homo sapiens_hsa003601.34522527
36Basal cell carcinoma_Homo sapiens_hsa052171.33858747
37Sphingolipid metabolism_Homo sapiens_hsa006001.33680771
38Pentose phosphate pathway_Homo sapiens_hsa000301.31433229
39Histidine metabolism_Homo sapiens_hsa003401.30309927
40Insulin secretion_Homo sapiens_hsa049111.27826485
41Carbon metabolism_Homo sapiens_hsa012001.25516192
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.25239670
43Tyrosine metabolism_Homo sapiens_hsa003501.24503864
44Collecting duct acid secretion_Homo sapiens_hsa049661.23711010
45Steroid biosynthesis_Homo sapiens_hsa001001.23674450
46DNA replication_Homo sapiens_hsa030301.21893612
47Phototransduction_Homo sapiens_hsa047441.21378237
48Glycerolipid metabolism_Homo sapiens_hsa005611.17262345
49Hedgehog signaling pathway_Homo sapiens_hsa043401.16459114
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16026027
51Fructose and mannose metabolism_Homo sapiens_hsa000511.15359902
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14037777
53ABC transporters_Homo sapiens_hsa020101.12753276
54One carbon pool by folate_Homo sapiens_hsa006701.12392405
55Retinol metabolism_Homo sapiens_hsa008301.11898046
56Basal transcription factors_Homo sapiens_hsa030221.10905229
57Mismatch repair_Homo sapiens_hsa034301.09552984
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.07190085
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06241719
60Nicotine addiction_Homo sapiens_hsa050331.03796545
61N-Glycan biosynthesis_Homo sapiens_hsa005101.03477749
62Homologous recombination_Homo sapiens_hsa034401.02908243
63Non-homologous end-joining_Homo sapiens_hsa034501.02270178
64Biosynthesis of amino acids_Homo sapiens_hsa012301.01745555
65Parkinsons disease_Homo sapiens_hsa050121.00886723
66Thyroid hormone synthesis_Homo sapiens_hsa049180.99103707
67Oocyte meiosis_Homo sapiens_hsa041140.98912272
68Olfactory transduction_Homo sapiens_hsa047400.95569351
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94280624
70Dorso-ventral axis formation_Homo sapiens_hsa043200.92416925
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92119256
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88859517
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88215347
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87571717
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87291621
76Glutathione metabolism_Homo sapiens_hsa004800.86930425
77Renin secretion_Homo sapiens_hsa049240.86659693
78Folate biosynthesis_Homo sapiens_hsa007900.83429571
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83302728
80Base excision repair_Homo sapiens_hsa034100.83057299
81RNA degradation_Homo sapiens_hsa030180.82609551
82Circadian entrainment_Homo sapiens_hsa047130.81993246
83Estrogen signaling pathway_Homo sapiens_hsa049150.81606418
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79413932
85Vibrio cholerae infection_Homo sapiens_hsa051100.77845164
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74389214
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.73553917
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72267535
89Melanogenesis_Homo sapiens_hsa049160.70517788
90Ovarian steroidogenesis_Homo sapiens_hsa049130.69585136
91Pyrimidine metabolism_Homo sapiens_hsa002400.69534506
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68927382
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68062543
94Synaptic vesicle cycle_Homo sapiens_hsa047210.66894948
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66474368
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.65505083
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65113154
98Arachidonic acid metabolism_Homo sapiens_hsa005900.64066482
99Cocaine addiction_Homo sapiens_hsa050300.63906743
100Metabolic pathways_Homo sapiens_hsa011000.61939608
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60035571
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59878201
103Nucleotide excision repair_Homo sapiens_hsa034200.59697208
104Wnt signaling pathway_Homo sapiens_hsa043100.59389673
105Alzheimers disease_Homo sapiens_hsa050100.59195939
106Taste transduction_Homo sapiens_hsa047420.58575558
107Calcium signaling pathway_Homo sapiens_hsa040200.58363460
108TGF-beta signaling pathway_Homo sapiens_hsa043500.57786722
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57206503
110Salivary secretion_Homo sapiens_hsa049700.56820249
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.55975599
112Galactose metabolism_Homo sapiens_hsa000520.55667019
113Butanoate metabolism_Homo sapiens_hsa006500.54733073
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53737053
115Tryptophan metabolism_Homo sapiens_hsa003800.53345198
116Peroxisome_Homo sapiens_hsa041460.51789840
117Alcoholism_Homo sapiens_hsa050340.51132920
118Oxidative phosphorylation_Homo sapiens_hsa001900.50085249
119Ether lipid metabolism_Homo sapiens_hsa005650.48644403
120Chemical carcinogenesis_Homo sapiens_hsa052040.48446881
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.47817954
122Cell cycle_Homo sapiens_hsa041100.47166962
123Tight junction_Homo sapiens_hsa045300.46334264
124Sulfur relay system_Homo sapiens_hsa041220.46272512
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45694951
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44941331
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44158484
128Long-term potentiation_Homo sapiens_hsa047200.42589950
129Cardiac muscle contraction_Homo sapiens_hsa042600.42048633
130Lysine degradation_Homo sapiens_hsa003100.39920804
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.39909975
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39765709
133Arginine and proline metabolism_Homo sapiens_hsa003300.38728586
134Fatty acid elongation_Homo sapiens_hsa000620.37866735
135Serotonergic synapse_Homo sapiens_hsa047260.37532760
136Mineral absorption_Homo sapiens_hsa049780.37189397
137Fat digestion and absorption_Homo sapiens_hsa049750.36781646
138Protein digestion and absorption_Homo sapiens_hsa049740.36755715
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34834859
140RNA transport_Homo sapiens_hsa030130.34685747
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33345116
142Systemic lupus erythematosus_Homo sapiens_hsa053220.32051211

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