FAM189A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.30720639
2synaptic vesicle maturation (GO:0016188)6.04328877
3locomotory exploration behavior (GO:0035641)6.02121469
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.92425275
5vocalization behavior (GO:0071625)5.72337904
6glutamate secretion (GO:0014047)5.63469191
7synaptic vesicle exocytosis (GO:0016079)5.61778019
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.60311715
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.58005465
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53138348
11regulation of glutamate receptor signaling pathway (GO:1900449)5.31830753
12regulation of synaptic vesicle exocytosis (GO:2000300)5.21247862
13protein localization to synapse (GO:0035418)5.08695025
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.98821935
15regulation of synaptic vesicle transport (GO:1902803)4.82428160
16exploration behavior (GO:0035640)4.80331860
17regulation of neuronal synaptic plasticity (GO:0048168)4.74056744
18neuron cell-cell adhesion (GO:0007158)4.71821227
19synaptic transmission, glutamatergic (GO:0035249)4.61947405
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.61410525
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.57496804
22neurotransmitter secretion (GO:0007269)4.45118449
23neurotransmitter-gated ion channel clustering (GO:0072578)4.38543965
24neuronal action potential propagation (GO:0019227)4.38529460
25glutamate receptor signaling pathway (GO:0007215)4.37279363
26neuron-neuron synaptic transmission (GO:0007270)4.22267306
27regulation of synapse structural plasticity (GO:0051823)4.21029598
28dendritic spine morphogenesis (GO:0060997)4.14296288
29long-term memory (GO:0007616)4.12497167
30layer formation in cerebral cortex (GO:0021819)4.07358080
31L-amino acid import (GO:0043092)4.06353278
32positive regulation of membrane potential (GO:0045838)3.99294082
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.96948502
34positive regulation of synapse maturation (GO:0090129)3.93948611
35proline transport (GO:0015824)3.92301606
36neuron recognition (GO:0008038)3.91930229
37regulation of synaptic plasticity (GO:0048167)3.87775711
38axonal fasciculation (GO:0007413)3.79332160
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77930904
40regulation of postsynaptic membrane potential (GO:0060078)3.76614979
41amino acid import (GO:0043090)3.72057498
42regulation of dendritic spine morphogenesis (GO:0061001)3.70196660
43cerebellar granule cell differentiation (GO:0021707)3.69690543
44long-term synaptic potentiation (GO:0060291)3.67113082
45gamma-aminobutyric acid transport (GO:0015812)3.63333569
46regulation of voltage-gated calcium channel activity (GO:1901385)3.63319737
47synaptic vesicle endocytosis (GO:0048488)3.61714722
48postsynaptic membrane organization (GO:0001941)3.55620610
49neurotransmitter transport (GO:0006836)3.53437084
50regulation of neurotransmitter secretion (GO:0046928)3.49997426
51positive regulation of neurotransmitter secretion (GO:0001956)3.49278950
52G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.48435206
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48377967
54cellular potassium ion homeostasis (GO:0030007)3.46004707
55cerebellar Purkinje cell differentiation (GO:0021702)3.45610758
56regulation of vesicle fusion (GO:0031338)3.44994671
57axon ensheathment in central nervous system (GO:0032291)3.41387094
58central nervous system myelination (GO:0022010)3.41387094
59potassium ion homeostasis (GO:0055075)3.40282558
60activation of protein kinase A activity (GO:0034199)3.39375305
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.38534792
62positive regulation of neurotransmitter transport (GO:0051590)3.38453603
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37722404
64transmission of nerve impulse (GO:0019226)3.35568996
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.35152288
66potassium ion import (GO:0010107)3.34932278
67neuromuscular process controlling balance (GO:0050885)3.31513103
68dendrite morphogenesis (GO:0048813)3.30057047
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29018077
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28923004
71regulation of neurotransmitter levels (GO:0001505)3.28779619
72negative regulation of dendrite morphogenesis (GO:0050774)3.28167290
73dendritic spine organization (GO:0097061)3.26967470
74innervation (GO:0060384)3.26781996
75presynaptic membrane assembly (GO:0097105)3.26173844
76regulation of neurotransmitter transport (GO:0051588)3.21955357
77behavioral fear response (GO:0001662)3.20723892
78behavioral defense response (GO:0002209)3.20723892
79membrane depolarization (GO:0051899)3.18795710
80learning (GO:0007612)3.16921707
81response to histamine (GO:0034776)3.15614398
82positive regulation of synaptic transmission (GO:0050806)3.14614406
83regulation of synaptic transmission (GO:0050804)3.13105661
84regulation of dendritic spine development (GO:0060998)3.12759094
85sodium ion export (GO:0071436)3.12756541
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10301237
87presynaptic membrane organization (GO:0097090)3.09816359
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08450359
89membrane depolarization during action potential (GO:0086010)3.08122573
90auditory behavior (GO:0031223)3.08088771
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08056996
92synaptic transmission (GO:0007268)3.04319896
93positive regulation of dendritic spine development (GO:0060999)3.04287291
94response to auditory stimulus (GO:0010996)3.03489456
95vesicle transport along microtubule (GO:0047496)3.03269294
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03091279
97chemosensory behavior (GO:0007635)3.02904234
98regulation of synapse maturation (GO:0090128)3.01649150
99neuronal ion channel clustering (GO:0045161)3.01439649
100cell communication by electrical coupling (GO:0010644)3.01278869
101cell migration in hindbrain (GO:0021535)3.00240202
102fear response (GO:0042596)2.99622037
103neuromuscular process controlling posture (GO:0050884)2.99413161
104social behavior (GO:0035176)2.98504561
105intraspecies interaction between organisms (GO:0051703)2.98504561
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98196641
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.97788586
108synaptic vesicle transport (GO:0048489)2.95252719
109establishment of synaptic vesicle localization (GO:0097480)2.95252719
110cochlea development (GO:0090102)2.94121613
111cellular sodium ion homeostasis (GO:0006883)2.92117363
112central nervous system projection neuron axonogenesis (GO:0021952)2.92053136
113neuromuscular process (GO:0050905)2.91821530
114regulation of ARF protein signal transduction (GO:0032012)2.91689966
115positive regulation of dendrite development (GO:1900006)2.90747278
116mechanosensory behavior (GO:0007638)2.83210743
117neuromuscular synaptic transmission (GO:0007274)2.82222433
118acidic amino acid transport (GO:0015800)2.80865521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.77142220
2GBX2_23144817_ChIP-Seq_PC3_Human3.65495792
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19087712
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09903361
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02363011
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.77261744
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72156245
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72156245
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67798259
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.65011899
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64687171
12* DROSHA_22980978_ChIP-Seq_HELA_Human2.57442521
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55849234
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.53740809
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51841707
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51273469
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43988162
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29019008
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.27773402
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.26266255
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.23760374
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.19751501
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13016822
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12078767
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.05850908
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05037617
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97733268
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89496491
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87354482
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84014371
31AR_21572438_ChIP-Seq_LNCaP_Human1.79575014
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75807645
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70912880
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70741426
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.67934428
36SMAD4_21799915_ChIP-Seq_A2780_Human1.61602518
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59262158
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.51497431
39TAF15_26573619_Chip-Seq_HEK293_Human1.47728990
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42515733
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42174378
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40756081
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39690669
44ZNF274_21170338_ChIP-Seq_K562_Hela1.39338716
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38183739
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36446516
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34509579
48P300_19829295_ChIP-Seq_ESCs_Human1.33925497
49* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33439531
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.32423005
51CTCF_27219007_Chip-Seq_Bcells_Human1.30807466
52* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29621093
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29534651
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.29082432
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28380419
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25988195
57TET1_21490601_ChIP-Seq_MESCs_Mouse1.24972335
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.24629538
59AR_25329375_ChIP-Seq_VCAP_Human1.23712724
60AR_19668381_ChIP-Seq_PC3_Human1.22985937
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22812220
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22622466
63* STAT3_23295773_ChIP-Seq_U87_Human1.19870267
64* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17890936
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16066693
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16017176
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.13096754
68* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11723594
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11556579
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.10499990
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10263558
72KDM2B_26808549_Chip-Seq_K562_Human1.08784849
73* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07511020
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07437756
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07206290
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07200974
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06766773
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.06732222
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06531123
80* TCF4_23295773_ChIP-Seq_U87_Human1.06129071
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.05760357
82RNF2_27304074_Chip-Seq_NSC_Mouse1.05575676
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05294307
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04264528
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.04241245
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03588677
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02293114
88IGF1R_20145208_ChIP-Seq_DFB_Human1.01526199
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01047812
90AHR_22903824_ChIP-Seq_MCF-7_Human1.00784100
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99911114
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99399180
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.96955994
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96741351
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.95912706
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95850484
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.95380583
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94117231
99FUS_26573619_Chip-Seq_HEK293_Human0.93829253
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93464165
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93464165
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.93460476
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92658722
104* RUNX2_22187159_ChIP-Seq_PCA_Human0.92090626
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91939260
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90850264
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90377946
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88384031
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87795307
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87764882
111* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87739633
112SOX9_26525672_Chip-Seq_HEART_Mouse0.86856717
113TP53_16413492_ChIP-PET_HCT116_Human0.86316092
114JUN_21703547_ChIP-Seq_K562_Human0.86292852
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86254236
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86155897
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84510712
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84151208
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84125135
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84038055
121DPY_21335234_ChIP-Seq_ESCs_Mouse0.81240917
122RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80890457
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79913432
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.79379431
125OCT4_19829295_ChIP-Seq_ESCs_Human0.78003327
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76518037
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75113653
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.72890537
129CREB1_26743006_Chip-Seq_LNCaP_Human0.72423069
130SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.72305174
131POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.72285441
132* KLF4_19829295_ChIP-Seq_ESCs_Human0.70809160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.34285892
2MP0003880_abnormal_central_pattern5.04808691
3MP0003635_abnormal_synaptic_transmissio4.36071416
4MP0004270_analgesia3.92116333
5MP0002063_abnormal_learning/memory/cond3.54775462
6MP0009745_abnormal_behavioral_response3.49555105
7MP0002064_seizures3.21652469
8MP0001968_abnormal_touch/_nociception3.05979418
9MP0002572_abnormal_emotion/affect_behav2.88263605
10MP0009046_muscle_twitch2.74176718
11MP0002822_catalepsy2.60733270
12MP0002734_abnormal_mechanical_nocicepti2.58813725
13MP0002272_abnormal_nervous_system2.54168378
14MP0005423_abnormal_somatic_nervous2.49536645
15MP0001486_abnormal_startle_reflex2.44258230
16MP0002736_abnormal_nociception_after2.34916247
17MP0001501_abnormal_sleep_pattern2.31979886
18MP0002735_abnormal_chemical_nociception2.26346132
19MP0009780_abnormal_chondrocyte_physiolo2.24320197
20MP0001440_abnormal_grooming_behavior2.11908342
21MP0002733_abnormal_thermal_nociception1.99830853
22MP0000778_abnormal_nervous_system1.92074543
23MP0001970_abnormal_pain_threshold1.90512069
24MP0003787_abnormal_imprinting1.85622871
25MP0004858_abnormal_nervous_system1.85076599
26MP0004811_abnormal_neuron_physiology1.84740732
27MP0002067_abnormal_sensory_capabilities1.84113311
28MP0008569_lethality_at_weaning1.81641224
29MP0002557_abnormal_social/conspecific_i1.78945271
30MP0002184_abnormal_innervation1.77274540
31MP0003123_paternal_imprinting1.75930255
32MP0003122_maternal_imprinting1.74997526
33MP0003879_abnormal_hair_cell1.70930455
34MP0003329_amyloid_beta_deposits1.70688905
35MP0005646_abnormal_pituitary_gland1.69688155
36MP0002909_abnormal_adrenal_gland1.67942606
37MP0006276_abnormal_autonomic_nervous1.64494197
38MP0005645_abnormal_hypothalamus_physiol1.63542196
39MP0005386_behavior/neurological_phenoty1.56819907
40MP0004924_abnormal_behavior1.56819907
41MP0000955_abnormal_spinal_cord1.55622441
42MP0008877_abnormal_DNA_methylation1.46308199
43MP0002882_abnormal_neuron_morphology1.40746374
44MP0002066_abnormal_motor_capabilities/c1.39890425
45MP0004885_abnormal_endolymph1.37189394
46MP0001529_abnormal_vocalization1.37183302
47MP0001984_abnormal_olfaction1.35763944
48MP0001502_abnormal_circadian_rhythm1.31189073
49MP0003633_abnormal_nervous_system1.29109846
50MP0000566_synostosis1.28945842
51MP0001905_abnormal_dopamine_level1.19049516
52MP0001346_abnormal_lacrimal_gland1.13995109
53MP0002152_abnormal_brain_morphology1.13004173
54MP0004142_abnormal_muscle_tone1.11977507
55MP0008961_abnormal_basal_metabolism1.09890074
56MP0003631_nervous_system_phenotype1.09135675
57MP0000569_abnormal_digit_pigmentation1.05359954
58MP0001188_hyperpigmentation1.02871503
59MP0002069_abnormal_eating/drinking_beha0.99497544
60MP0005623_abnormal_meninges_morphology0.98595447
61MP0000751_myopathy0.95016437
62MP0008872_abnormal_physiological_respon0.93256197
63MP0003283_abnormal_digestive_organ0.92354974
64MP0003075_altered_response_to0.91661195
65MP0010386_abnormal_urinary_bladder0.91197641
66MP0001177_atelectasis0.90897513
67MP0008874_decreased_physiological_sensi0.89789087
68MP0003938_abnormal_ear_development0.86217574
69MP0005535_abnormal_body_temperature0.86072517
70MP0009379_abnormal_foot_pigmentation0.84406516
71MP0001299_abnormal_eye_distance/0.83970357
72MP0010030_abnormal_orbit_morphology0.83241209
73MP0000537_abnormal_urethra_morphology0.79793919
74MP0006292_abnormal_olfactory_placode0.78275502
75MP0004145_abnormal_muscle_electrophysio0.77555164
76MP0002229_neurodegeneration0.77265055
77MP0004085_abnormal_heartbeat0.76417161
78MP0002249_abnormal_larynx_morphology0.75370877
79MP0001963_abnormal_hearing_physiology0.74780487
80MP0000631_abnormal_neuroendocrine_gland0.74365735
81MP0002837_dystrophic_cardiac_calcinosis0.74362439
82MP0004147_increased_porphyrin_level0.74093624
83MP0003119_abnormal_digestive_system0.73764630
84MP0010234_abnormal_vibrissa_follicle0.73565557
85MP0000013_abnormal_adipose_tissue0.72979803
86MP0003632_abnormal_nervous_system0.71560891
87MP0000026_abnormal_inner_ear0.71357702
88MP0000604_amyloidosis0.71341889
89MP0005499_abnormal_olfactory_system0.71054205
90MP0005394_taste/olfaction_phenotype0.71054205
91MP0002876_abnormal_thyroid_physiology0.70746919
92MP0003137_abnormal_impulse_conducting0.67978743
93MP0000579_abnormal_nail_morphology0.67370055
94MP0003121_genomic_imprinting0.67020764
95MP0002752_abnormal_somatic_nervous0.67011725
96MP0005551_abnormal_eye_electrophysiolog0.66057627
97MP0004510_myositis0.65557722
98MP0004233_abnormal_muscle_weight0.65060046
99MP0004742_abnormal_vestibular_system0.64685022
100MP0009672_abnormal_birth_weight0.64536717
101MP0004484_altered_response_of0.64328409
102MP0003634_abnormal_glial_cell0.62824280
103MP0004215_abnormal_myocardial_fiber0.62088217
104MP0001664_abnormal_digestion0.61914093
105MP0004133_heterotaxia0.61621899
106MP0003690_abnormal_glial_cell0.61138687
107MP0010768_mortality/aging0.60542118
108MP0003861_abnormal_nervous_system0.60104439
109MP0002081_perinatal_lethality0.59408767
110MP0005167_abnormal_blood-brain_barrier0.58643844
111MP0000049_abnormal_middle_ear0.57934601
112MP0000462_abnormal_digestive_system0.55631596
113MP0002638_abnormal_pupillary_reflex0.55399776
114MP0003172_abnormal_lysosome_physiology0.54600320
115MP0001986_abnormal_taste_sensitivity0.54508357
116MP0002090_abnormal_vision0.54432629
117MP0010769_abnormal_survival0.54089603
118MP0002234_abnormal_pharynx_morphology0.53960422
119MP0000920_abnormal_myelination0.53855385
120MP0001485_abnormal_pinna_reflex0.53463149
121MP0001943_abnormal_respiration0.52660541
122MP0005409_darkened_coat_color0.52131973
123MP0002082_postnatal_lethality0.51746206
124MP0010770_preweaning_lethality0.51746206

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.43066039
2Myokymia (HP:0002411)7.26082377
3Focal seizures (HP:0007359)6.04938235
4Visual hallucinations (HP:0002367)5.24855001
5Epileptic encephalopathy (HP:0200134)5.11224474
6Atonic seizures (HP:0010819)4.75920441
7Febrile seizures (HP:0002373)4.63105647
8Progressive cerebellar ataxia (HP:0002073)4.45922018
9Absence seizures (HP:0002121)4.22659851
10Dialeptic seizures (HP:0011146)3.94890249
11Generalized tonic-clonic seizures (HP:0002069)3.91905478
12Impaired vibration sensation in the lower limbs (HP:0002166)3.75383875
13Action tremor (HP:0002345)3.72502339
14Supranuclear gaze palsy (HP:0000605)3.54001363
15Broad-based gait (HP:0002136)3.51174789
16Hyperventilation (HP:0002883)3.41848657
17Poor eye contact (HP:0000817)3.34631951
18Ankle clonus (HP:0011448)3.34077586
19Depression (HP:0000716)3.31510979
20Gaze-evoked nystagmus (HP:0000640)3.30081275
21Amblyopia (HP:0000646)3.23279441
22Abnormal eating behavior (HP:0100738)3.22836116
23Dysdiadochokinesis (HP:0002075)3.20601168
24Dysmetria (HP:0001310)3.14785478
25Postural instability (HP:0002172)3.11977428
26Urinary bladder sphincter dysfunction (HP:0002839)3.11607831
27Abnormal social behavior (HP:0012433)3.05130432
28Impaired social interactions (HP:0000735)3.05130432
29Papilledema (HP:0001085)3.04410380
30Genetic anticipation (HP:0003743)2.92168874
31Truncal ataxia (HP:0002078)2.88305940
32Tetraplegia (HP:0002445)2.86103470
33Anxiety (HP:0000739)2.84680135
34Abnormality of the lower motor neuron (HP:0002366)2.84488159
35Excessive salivation (HP:0003781)2.84010974
36Drooling (HP:0002307)2.84010974
37Mutism (HP:0002300)2.75424404
38Impaired smooth pursuit (HP:0007772)2.74511257
39Urinary urgency (HP:0000012)2.71339344
40Polyphagia (HP:0002591)2.69505754
41Epileptiform EEG discharges (HP:0011182)2.66267281
42Torticollis (HP:0000473)2.66057251
43Focal dystonia (HP:0004373)2.60696503
44Bradykinesia (HP:0002067)2.60186930
45Impaired vibratory sensation (HP:0002495)2.50590202
46Spastic gait (HP:0002064)2.50247678
47Hemiparesis (HP:0001269)2.49511954
48Stereotypic behavior (HP:0000733)2.47112862
49EEG with generalized epileptiform discharges (HP:0011198)2.45277471
50Diplopia (HP:0000651)2.41654394
51Abnormality of binocular vision (HP:0011514)2.41654394
52Fetal akinesia sequence (HP:0001989)2.40401109
53Absent speech (HP:0001344)2.39042224
54Abnormality of ocular smooth pursuit (HP:0000617)2.38745988
55Cerebral hypomyelination (HP:0006808)2.37453763
56Scanning speech (HP:0002168)2.35515958
57Hypsarrhythmia (HP:0002521)2.34600868
58Cerebral inclusion bodies (HP:0100314)2.34512944
59Failure to thrive in infancy (HP:0001531)2.26870504
60Intention tremor (HP:0002080)2.26325137
61Aplasia involving bones of the extremities (HP:0009825)2.25729840
62Aplasia involving bones of the upper limbs (HP:0009823)2.25729840
63Hemiplegia (HP:0002301)2.25283010
64Ventricular fibrillation (HP:0001663)2.23862204
65Sleep apnea (HP:0010535)2.22858550
66Megalencephaly (HP:0001355)2.22499673
67Craniofacial dystonia (HP:0012179)2.21855700
68Progressive inability to walk (HP:0002505)2.21634521
69Congenital malformation of the right heart (HP:0011723)2.19057973
70Double outlet right ventricle (HP:0001719)2.19057973
71Neurofibrillary tangles (HP:0002185)2.18414959
72Limb dystonia (HP:0002451)2.18103807
73Status epilepticus (HP:0002133)2.17027060
74Turricephaly (HP:0000262)2.12253488
75Choreoathetosis (HP:0001266)2.10696748
76Dysmetric saccades (HP:0000641)2.10316092
77Lower limb muscle weakness (HP:0007340)2.09956191
78Obstructive sleep apnea (HP:0002870)2.09340151
79Termporal pattern (HP:0011008)2.07456460
80Insidious onset (HP:0003587)2.07456460
81Split foot (HP:0001839)2.06701851
82Pointed chin (HP:0000307)2.05150798
83Protruding tongue (HP:0010808)2.04800869
84Annular pancreas (HP:0001734)2.02888531
85Morphological abnormality of the pyramidal tract (HP:0002062)2.02717162
86Generalized myoclonic seizures (HP:0002123)2.01368837
87Blue irides (HP:0000635)2.00991425
88Inability to walk (HP:0002540)1.99597246
89Abnormality of the corticospinal tract (HP:0002492)1.99137276
90Incomplete penetrance (HP:0003829)1.98666625
91Bronchomalacia (HP:0002780)1.97572084
92Bundle branch block (HP:0011710)1.96802523
93Neuronal loss in central nervous system (HP:0002529)1.93832320
94Agitation (HP:0000713)1.92428345
95Abnormality of salivation (HP:0100755)1.91187307
96Peripheral hypomyelination (HP:0007182)1.90865887
97Gait ataxia (HP:0002066)1.90446519
98Insomnia (HP:0100785)1.90228262
99Hypoventilation (HP:0002791)1.90207581
100Spastic tetraparesis (HP:0001285)1.89771274
101Pheochromocytoma (HP:0002666)1.87183015
102Specific learning disability (HP:0001328)1.82506618
103Amyotrophic lateral sclerosis (HP:0007354)1.81009166
104Psychosis (HP:0000709)1.79614713
105Spastic tetraplegia (HP:0002510)1.79581541
106Poor suck (HP:0002033)1.78978018
107Delusions (HP:0000746)1.77334582
108Abnormal EKG (HP:0003115)1.76615568
109Deep palmar crease (HP:0006191)1.76564786
110Overriding aorta (HP:0002623)1.74501649
111Lower limb amyotrophy (HP:0007210)1.74132277
112Rigidity (HP:0002063)1.73889564
113Inappropriate behavior (HP:0000719)1.73120939
114Lower limb asymmetry (HP:0100559)1.72912457
115Akinesia (HP:0002304)1.70148964
116Clonus (HP:0002169)1.69925284
117Aplasia of the phalanges of the hand (HP:0009802)1.69894928
118Truncus arteriosus (HP:0001660)1.68181515
119CNS hypomyelination (HP:0003429)1.67746353
120Abnormality of the labia minora (HP:0012880)1.64663901
121Apathy (HP:0000741)1.64451202
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.61571219
123Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.61571219
124Abnormality of the aortic arch (HP:0012303)1.60484375
125Unsteady gait (HP:0002317)1.59187388
126Thickened helices (HP:0000391)1.57720826
127Retinal dysplasia (HP:0007973)1.52986950
128Diminished motivation (HP:0000745)1.51703252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.17497988
2EPHA44.82532178
3MAP3K94.09199595
4MAP3K42.96732468
5MARK12.91268643
6DAPK22.77284731
7MAP2K72.67875256
8MINK12.62160326
9TNIK2.28490619
10PAK62.17468187
11MAP3K122.12483833
12PRKD32.08767149
13DAPK11.93949405
14KSR21.92031903
15NTRK21.89821568
16MAP2K41.88748809
17CASK1.87189414
18CAMKK11.82964528
19KSR11.76872797
20RIPK41.76329549
21PRPF4B1.61199207
22NTRK11.53722851
23CDK51.52869323
24STK381.47999625
25PLK21.47096764
26CDK191.43892641
27BRSK11.38569462
28MAPK131.35808775
29TYRO31.31474657
30PRKCG1.26802620
31FES1.24469198
32GRK51.20814236
33UHMK11.14531815
34SIK21.11320774
35RIPK11.08885065
36TSSK61.06090550
37MAP3K21.03765735
38CAMK2A1.02991914
39TAOK11.01447097
40ARAF1.00976149
41CAMK11.00724170
42PNCK0.99969338
43TIE10.98865622
44MAP3K130.95603470
45CDK180.92536254
46CAMK2B0.90545777
47CDK150.89130606
48CDK140.84744206
49LATS20.83922539
50PTK2B0.82651441
51DYRK20.81819872
52BMPR20.81092580
53CAMKK20.80399018
54STK110.80387607
55RET0.79999957
56SGK4940.78378242
57SGK2230.78378242
58CDK11A0.77767608
59PRKCH0.75445197
60PKN10.74964934
61PHKG20.70160145
62PHKG10.70160145
63SGK10.69270667
64BRAF0.69132000
65RAF10.68928087
66PAK30.68918793
67CSNK1G20.68889061
68SGK20.68337061
69CAMK1D0.67005861
70OXSR10.66584645
71PINK10.65435212
72PDK10.65290883
73MARK20.65064608
74CSNK1G30.63403070
75FER0.60811462
76DYRK1A0.60745096
77CCNB10.58870462
78SGK30.58855521
79ALK0.58154049
80AKT30.57523499
81LIMK10.57119867
82PLK30.55968209
83MAP3K10.53515542
84MAP3K60.52050027
85PDPK10.52039490
86CSNK1G10.51726479
87TNK20.49243150
88CAMK40.48715036
89CDC42BPA0.47899270
90EPHB20.47753603
91SIK30.46238479
92TAF10.46053507
93RPS6KA30.45941798
94NME10.45430049
95PRKCE0.45375606
96PRKCZ0.45345759
97MAP3K70.44747963
98LMTK20.44536461
99MAP3K110.44308800
100DAPK30.44042745
101CAMK2D0.43792291
102MAPK120.42063686
103FGR0.41072753
104CAMK2G0.40555562
105CAMK1G0.40488695
106NEK10.39619088
107FYN0.39366769
108WNK30.38164437
109MAPKAPK50.37424166
110FGFR20.36671692
111NEK60.36073682
112MAPK100.35857970
113CSNK1E0.35797436
114CDK30.35633551
115BCR0.35244775
116BUB10.35170034
117CSNK1A1L0.34987151
118DDR20.33066196
119MAP2K10.32903570
120SCYL20.32894946
121TAOK20.32582429
122ROCK20.30956239
123CSNK1D0.29115366
124PRKG20.28973471

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77620603
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36034033
3Long-term potentiation_Homo sapiens_hsa047202.81781859
4Circadian entrainment_Homo sapiens_hsa047132.81338723
5Olfactory transduction_Homo sapiens_hsa047402.71311377
6Amphetamine addiction_Homo sapiens_hsa050312.66867693
7Glutamatergic synapse_Homo sapiens_hsa047242.65142869
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64736239
9GABAergic synapse_Homo sapiens_hsa047272.61751960
10Vitamin B6 metabolism_Homo sapiens_hsa007502.52038109
11Morphine addiction_Homo sapiens_hsa050322.49397048
12Dopaminergic synapse_Homo sapiens_hsa047282.22387025
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16504837
14Salivary secretion_Homo sapiens_hsa049702.15883987
15Insulin secretion_Homo sapiens_hsa049112.15734621
16Cholinergic synapse_Homo sapiens_hsa047251.94513135
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94015583
18Gastric acid secretion_Homo sapiens_hsa049711.85888621
19Long-term depression_Homo sapiens_hsa047301.69173613
20Taste transduction_Homo sapiens_hsa047421.68173933
21Oxytocin signaling pathway_Homo sapiens_hsa049211.67972750
22Cocaine addiction_Homo sapiens_hsa050301.66431648
23Calcium signaling pathway_Homo sapiens_hsa040201.62971865
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61863643
25Serotonergic synapse_Homo sapiens_hsa047261.61158978
26Renin secretion_Homo sapiens_hsa049241.60994739
27Collecting duct acid secretion_Homo sapiens_hsa049661.48991912
28GnRH signaling pathway_Homo sapiens_hsa049121.46213873
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41312836
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33188358
31Gap junction_Homo sapiens_hsa045401.33158948
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31588673
33cAMP signaling pathway_Homo sapiens_hsa040241.28696471
34Glioma_Homo sapiens_hsa052141.27378383
35Type II diabetes mellitus_Homo sapiens_hsa049301.23883006
36Axon guidance_Homo sapiens_hsa043601.20532001
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18481776
38Estrogen signaling pathway_Homo sapiens_hsa049151.18031832
39ErbB signaling pathway_Homo sapiens_hsa040121.15970595
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15702672
41Melanogenesis_Homo sapiens_hsa049161.08874116
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01271480
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99605490
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98294454
45Vibrio cholerae infection_Homo sapiens_hsa051100.97530932
46Oocyte meiosis_Homo sapiens_hsa041140.89022987
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88252016
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.87287664
49Nitrogen metabolism_Homo sapiens_hsa009100.86707746
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.83709350
51Thyroid hormone synthesis_Homo sapiens_hsa049180.82513831
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82305257
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81325693
54Choline metabolism in cancer_Homo sapiens_hsa052310.80142954
55Pancreatic secretion_Homo sapiens_hsa049720.79639092
56VEGF signaling pathway_Homo sapiens_hsa043700.74788994
57Hippo signaling pathway_Homo sapiens_hsa043900.74757755
58Dorso-ventral axis formation_Homo sapiens_hsa043200.73326753
59MAPK signaling pathway_Homo sapiens_hsa040100.72339120
60Cardiac muscle contraction_Homo sapiens_hsa042600.70120603
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.70029183
62Dilated cardiomyopathy_Homo sapiens_hsa054140.66900887
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65339244
64Alzheimers disease_Homo sapiens_hsa050100.65263000
65Ras signaling pathway_Homo sapiens_hsa040140.62896949
66Phototransduction_Homo sapiens_hsa047440.62536694
67Glucagon signaling pathway_Homo sapiens_hsa049220.62099560
68Circadian rhythm_Homo sapiens_hsa047100.61606923
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61446929
70Tight junction_Homo sapiens_hsa045300.60672930
71Arginine and proline metabolism_Homo sapiens_hsa003300.57713926
72Rap1 signaling pathway_Homo sapiens_hsa040150.57214892
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56968208
74mTOR signaling pathway_Homo sapiens_hsa041500.56093043
75Basal cell carcinoma_Homo sapiens_hsa052170.54322157
76Wnt signaling pathway_Homo sapiens_hsa043100.54008563
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53996674
78Hedgehog signaling pathway_Homo sapiens_hsa043400.53935752
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52683658
80Type I diabetes mellitus_Homo sapiens_hsa049400.52584651
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.51789116
82Alcoholism_Homo sapiens_hsa050340.50410074
83Inositol phosphate metabolism_Homo sapiens_hsa005620.49189961
84Endometrial cancer_Homo sapiens_hsa052130.49149316
85Endocytosis_Homo sapiens_hsa041440.47198011
86Non-small cell lung cancer_Homo sapiens_hsa052230.46081389
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45308416
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45081919
89Folate biosynthesis_Homo sapiens_hsa007900.45045331
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43941987
91Bile secretion_Homo sapiens_hsa049760.41874975
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41763023
93African trypanosomiasis_Homo sapiens_hsa051430.41002323
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40482650
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39993000
96Insulin signaling pathway_Homo sapiens_hsa049100.39892260
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36932837
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36910179
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36699763
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36661488
101Prion diseases_Homo sapiens_hsa050200.36556565
102Renal cell carcinoma_Homo sapiens_hsa052110.35656344
103Parkinsons disease_Homo sapiens_hsa050120.34447263
104Oxidative phosphorylation_Homo sapiens_hsa001900.33142266
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32854038
106Chemokine signaling pathway_Homo sapiens_hsa040620.32263937
107Colorectal cancer_Homo sapiens_hsa052100.31520279
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30797211
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29557060
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28882068
111Ovarian steroidogenesis_Homo sapiens_hsa049130.28070948
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26513309
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26467817
114AMPK signaling pathway_Homo sapiens_hsa041520.26325539
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25260868
116Arginine biosynthesis_Homo sapiens_hsa002200.24531606
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.23432212

Most similar genes based on co-expression Upload to Enrichr

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