FAM189A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone generation (GO:0006590)5.88337816
2surfactant homeostasis (GO:0043129)5.36345059
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.29545933
4sarcomere organization (GO:0045214)5.15205793
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.92512767
6cardiac myofibril assembly (GO:0055003)4.88890009
7thyroid hormone metabolic process (GO:0042403)4.63602497
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.56009651
9skeletal muscle contraction (GO:0003009)4.52031806
10regulation of cardioblast differentiation (GO:0051890)4.43141912
11chemical homeostasis within a tissue (GO:0048875)4.42814260
12ventricular cardiac muscle cell action potential (GO:0086005)4.42385092
13plasma membrane repair (GO:0001778)4.33819211
14myofibril assembly (GO:0030239)4.31770879
15muscle filament sliding (GO:0030049)4.13683769
16actin-myosin filament sliding (GO:0033275)4.13683769
17regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.12700910
18cardiac muscle contraction (GO:0060048)4.12085213
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.11780188
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.08661288
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.02884643
22hemidesmosome assembly (GO:0031581)3.97665635
23cardiac muscle cell development (GO:0055013)3.90711168
24cell communication involved in cardiac conduction (GO:0086065)3.89484319
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.84832160
26regulation of actin filament-based movement (GO:1903115)3.82022923
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78829200
28regulation of skeletal muscle contraction (GO:0014819)3.76264502
29actomyosin structure organization (GO:0031032)3.74769077
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.71921896
31response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.71710166
32cardiac cell development (GO:0055006)3.70502441
33actin-mediated cell contraction (GO:0070252)3.58598442
34skeletal muscle fiber development (GO:0048741)3.56311712
35heart trabecula formation (GO:0060347)3.50088358
36cell communication by electrical coupling (GO:0010644)3.46066206
37myotube cell development (GO:0014904)3.45425569
38cardiac chamber formation (GO:0003207)3.44791835
39relaxation of cardiac muscle (GO:0055119)3.44665361
40desmosome organization (GO:0002934)3.36928428
41cardiac muscle tissue morphogenesis (GO:0055008)3.36470967
42regulation of membrane repolarization (GO:0060306)3.35438439
43muscle fiber development (GO:0048747)3.33902490
44ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.32650519
45muscle system process (GO:0003012)3.31435280
46membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.23759250
47membrane repolarization during action potential (GO:0086011)3.23444155
48striated muscle contraction (GO:0006941)3.20562322
49negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.15449460
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.14957148
51muscle tissue morphogenesis (GO:0060415)3.13855646
52cardiac muscle hypertrophy (GO:0003300)3.13679647
53response to parathyroid hormone (GO:0071107)3.13075753
54tricarboxylic acid cycle (GO:0006099)3.12560818
55response to muscle activity (GO:0014850)3.12452582
56carnitine shuttle (GO:0006853)3.12338810
57regulation of the force of heart contraction (GO:0002026)3.11537972
58regulation of striated muscle contraction (GO:0006942)3.07632981
59cardiac muscle cell action potential involved in contraction (GO:0086002)3.07537900
60cardiac muscle cell action potential (GO:0086001)3.04493240
61regulation of relaxation of muscle (GO:1901077)3.04088075
62striated muscle adaptation (GO:0014888)3.04019706
63atrioventricular valve morphogenesis (GO:0003181)3.02951812
64striated muscle cell development (GO:0055002)3.01949813
65striated muscle hypertrophy (GO:0014897)3.01220731
66regulation of heart rate by cardiac conduction (GO:0086091)3.00615245
67negative regulation of protein localization to cell surface (GO:2000009)2.97656050
68actin filament-based movement (GO:0030048)2.96011822
69regulation of cardiac muscle cell contraction (GO:0086004)2.94496993
70membrane repolarization (GO:0086009)2.94462874
71sodium ion export (GO:0071436)2.93413261
72sodium ion homeostasis (GO:0055078)2.89459770
73cardiac conduction (GO:0061337)2.89163239
74response to inactivity (GO:0014854)2.88894819
75positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.88850478
76muscle cell cellular homeostasis (GO:0046716)2.86260265
77relaxation of smooth muscle (GO:0044557)2.86173159
78otic vesicle formation (GO:0030916)2.85991822
79regulation of phospholipid biosynthetic process (GO:0071071)2.85708701
80atrial septum morphogenesis (GO:0060413)2.85047790
81fatty acid transmembrane transport (GO:1902001)2.81756987
82regulation of heart rate (GO:0002027)2.81493880
83paraxial mesoderm development (GO:0048339)2.80891726
84regulation of p38MAPK cascade (GO:1900744)2.80668997
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80495586
86adult heart development (GO:0007512)2.80435384
87thyroid gland development (GO:0030878)2.80359522
88regulation of calcium ion transmembrane transporter activity (GO:1901019)2.79910907
89regulation of calcium ion transmembrane transport (GO:1903169)2.79910907
90hyperosmotic salinity response (GO:0042538)2.78973132
91regulation of skeletal muscle cell differentiation (GO:2001014)2.76007731
92muscle cell development (GO:0055001)2.75722257
93potassium ion import (GO:0010107)2.75093735
94regulation of acrosome reaction (GO:0060046)2.73817042
95negative regulation of hormone biosynthetic process (GO:0032353)2.72710652
96outflow tract septum morphogenesis (GO:0003148)2.72369084
97glycogen catabolic process (GO:0005980)2.72004828
98cardiac ventricle formation (GO:0003211)2.71499135
99regulation of cardiac muscle contraction (GO:0055117)2.70767532
100regulation of cell communication by electrical coupling (GO:0010649)2.69580084
101regulation of heart contraction (GO:0008016)2.69113832
102endocardial cushion morphogenesis (GO:0003203)2.68824425
103cGMP-mediated signaling (GO:0019934)2.68724158
104muscle cell fate commitment (GO:0042693)2.68649581
105epithelial cell-cell adhesion (GO:0090136)2.68228219
106negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66345245
107relaxation of muscle (GO:0090075)2.65517739
108myotube differentiation (GO:0014902)2.64297377
109regulation of sarcomere organization (GO:0060297)2.64098833
110regulation of ATPase activity (GO:0043462)2.63013540
111regulation of ATP catabolic process (GO:1903289)2.63013540
112negative regulation of potassium ion transport (GO:0043267)2.62443370
113L-amino acid import (GO:0043092)2.62393374
114skeletal muscle adaptation (GO:0043501)2.60918640
115heart valve formation (GO:0003188)2.59731341
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.58764850
117positive regulation of cardiac muscle tissue growth (GO:0055023)2.57688459
118positive regulation of cardiac muscle cell proliferation (GO:0060045)2.56073752
119creatine metabolic process (GO:0006600)2.55379078
120potassium ion export (GO:0071435)2.55091846
121sarcoplasmic reticulum calcium ion transport (GO:0070296)2.55063561
122regulation of endothelial cell differentiation (GO:0045601)2.54539384
123muscle hypertrophy (GO:0014896)2.53618159
124cellular sodium ion homeostasis (GO:0006883)2.50286800
125regulation of potassium ion transmembrane transporter activity (GO:1901016)2.48941079
126carnitine transmembrane transport (GO:1902603)2.48141518
127cGMP biosynthetic process (GO:0006182)2.47263899
128growth hormone secretion (GO:0030252)2.46791999
129lymphangiogenesis (GO:0001946)2.43057342
130regulation of vasculogenesis (GO:2001212)2.42950771
131regulation of potassium ion transmembrane transport (GO:1901379)2.42295889
132muscle contraction (GO:0006936)2.41777800
133cardiac muscle hypertrophy in response to stress (GO:0014898)2.39617700
134muscle hypertrophy in response to stress (GO:0003299)2.39617700
135cardiac muscle adaptation (GO:0014887)2.39617700
136renal filtration (GO:0097205)2.39255082
137vascular endothelial growth factor signaling pathway (GO:0038084)2.38681537
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.38341110
139heart process (GO:0003015)2.36455670
140heart contraction (GO:0060047)2.36455670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.13776430
2EP300_21415370_ChIP-Seq_HL-1_Mouse2.96072958
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.79766187
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.55518624
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.48008489
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41380936
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.40508615
8ZNF263_19887448_ChIP-Seq_K562_Human2.35034119
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30065903
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.26002626
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.13620316
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.13620316
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11856678
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05523032
15GBX2_23144817_ChIP-Seq_PC3_Human2.04032430
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99476164
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88443947
18CLOCK_20551151_ChIP-Seq_293T_Human1.85838022
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.84514389
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72591719
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68283717
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64499446
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61967732
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61124608
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60445209
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60445209
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56560613
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52945862
29GATA1_22025678_ChIP-Seq_K562_Human1.51765575
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50517762
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49235174
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48664134
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45610409
34AHR_22903824_ChIP-Seq_MCF-7_Human1.45499295
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43784526
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.40241865
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37551134
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36817454
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36082637
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33522005
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33466946
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32999072
43DROSHA_22980978_ChIP-Seq_HELA_Human1.31803290
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30127628
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29791677
46CJUN_26792858_Chip-Seq_BT549_Human1.29690092
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29578789
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.29272590
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28873249
50RACK7_27058665_Chip-Seq_MCF-7_Human1.27728774
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.27312717
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25439470
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25379492
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.24950102
55* EZH2_27294783_Chip-Seq_ESCs_Mouse1.23931595
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23654011
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23105007
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22849791
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.22408752
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.21212244
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.20974437
62* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20002275
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19619094
64KDM2B_26808549_Chip-Seq_K562_Human1.19501083
65LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18633464
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18036349
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.17982446
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17639048
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17593591
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17458590
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16780045
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16472844
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15792449
74SOX2_20726797_ChIP-Seq_SW620_Human1.15659426
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15235707
76SMAD4_21799915_ChIP-Seq_A2780_Human1.13654603
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13388242
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12877531
79EZH2_22144423_ChIP-Seq_EOC_Human1.11684311
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.11283537
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10544464
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10314375
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.10052501
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10001693
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10001693
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10001693
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09864874
88CTCF_27219007_Chip-Seq_Bcells_Human1.09598791
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.09231995
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.08659314
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07681451
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.06662519
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.06576630
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06343094
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06282263
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04838997
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04143556
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.03719518
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03563968
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03455629
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03266592
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02833059
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01772449
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01762548
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01681064
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00893023
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00113156
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00089017
109* KLF5_25053715_ChIP-Seq_YYC3_Human0.98218926
110AR_19668381_ChIP-Seq_PC3_Human0.97940248
111* TP63_22573176_ChIP-Seq_HFKS_Human0.96822438
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96646089
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96048492
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95783855
115* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95484669
116GF1_26923725_Chip-Seq_HPCs_Mouse0.94482273
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93178588
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92990106
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.92675517
120AR_21572438_ChIP-Seq_LNCaP_Human0.92287186
121BCAT_22108803_ChIP-Seq_LS180_Human0.91857462
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.91550789
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91490882
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.90617891
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90555938
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90486113
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88964838
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88850663
129LXR_22292898_ChIP-Seq_THP-1_Human0.88502078
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.88124289
131* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87872011
132TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87838580
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87686873
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87475485
135* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86728755
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86054695
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85374227
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.84551118
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84407116
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83009982
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82865829
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.82623996
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81527399
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80809606
145ELK3_25401928_ChIP-Seq_HUVEC_Human0.80480129
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.80240795
147* TP63_23658742_ChIP-Seq_EP156T_Human0.80000197
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79716482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.83716330
2MP0002837_dystrophic_cardiac_calcinosis4.57296133
3MP0000751_myopathy4.05054425
4MP0004036_abnormal_muscle_relaxation3.81093583
5MP0004215_abnormal_myocardial_fiber3.33848191
6MP0003646_muscle_fatigue3.01828764
7MP0005330_cardiomyopathy2.91662438
8MP0000749_muscle_degeneration2.72049276
9MP0003136_yellow_coat_color2.65097929
10MP0002972_abnormal_cardiac_muscle2.49890945
11MP0006138_congestive_heart_failure2.33257892
12MP0004087_abnormal_muscle_fiber2.30325962
13MP0008775_abnormal_heart_ventricle2.29185778
14MP0004272_abnormal_basement_membrane2.28522549
15MP0001958_emphysema2.25284423
16MP0005620_abnormal_muscle_contractility2.22451010
17MP0004484_altered_response_of2.14203956
18MP0010368_abnormal_lymphatic_system2.13112305
19MP0004782_abnormal_surfactant_physiolog2.08661609
20MP0005385_cardiovascular_system_phenoty2.07923927
21MP0001544_abnormal_cardiovascular_syste2.07923927
22MP0003137_abnormal_impulse_conducting2.06443241
23MP0004130_abnormal_muscle_cell2.01723800
24MP0000750_abnormal_muscle_regeneration1.99705253
25MP0003950_abnormal_plasma_membrane1.99678654
26MP0000383_abnormal_hair_follicle1.97633646
27MP0010630_abnormal_cardiac_muscle1.93695809
28MP0010030_abnormal_orbit_morphology1.92152079
29MP0010678_abnormal_skin_adnexa1.82863623
30MP0004085_abnormal_heartbeat1.80536327
31MP0003828_pulmonary_edema1.78216093
32MP0002106_abnormal_muscle_physiology1.76795186
33MP0001879_abnormal_lymphatic_vessel1.72012189
34MP0004270_analgesia1.68392659
35MP0005167_abnormal_blood-brain_barrier1.65412344
36MP0005275_abnormal_skin_tensile1.62770268
37MP0000747_muscle_weakness1.59177819
38MP0004145_abnormal_muscle_electrophysio1.57720280
39MP0000681_abnormal_thyroid_gland1.56732010
40MP0000733_abnormal_muscle_development1.55670456
41MP0005623_abnormal_meninges_morphology1.55391383
42MP0002269_muscular_atrophy1.52668343
43MP0010234_abnormal_vibrissa_follicle1.52470992
44MP0008438_abnormal_cutaneous_collagen1.52400469
45MP0005171_absent_coat_pigmentation1.49779978
46MP0003566_abnormal_cell_adhesion1.45317366
47MP0005369_muscle_phenotype1.45300366
48MP0008995_early_reproductive_senescence1.40054809
49MP0005670_abnormal_white_adipose1.32926632
50MP0002234_abnormal_pharynx_morphology1.31951397
51MP0002127_abnormal_cardiovascular_syste1.28306369
52MP0000759_abnormal_skeletal_muscle1.28292525
53MP0004043_abnormal_pH_regulation1.27687513
54MP0003705_abnormal_hypodermis_morpholog1.22876228
55MP0009780_abnormal_chondrocyte_physiolo1.20784447
56MP0002796_impaired_skin_barrier1.19666594
57MP0003890_abnormal_embryonic-extraembry1.19057576
58MP0002295_abnormal_pulmonary_circulatio1.17140476
59MP0005165_increased_susceptibility_to1.16683586
60MP0004185_abnormal_adipocyte_glucose1.16616838
61MP0001984_abnormal_olfaction1.16594315
62MP0004858_abnormal_nervous_system1.15043294
63MP0008004_abnormal_stomach_pH1.15042912
64MP0002332_abnormal_exercise_endurance1.13270258
65MP0009384_cardiac_valve_regurgitation1.12947121
66MP0000537_abnormal_urethra_morphology1.11846305
67MP0004233_abnormal_muscle_weight1.10692598
68MP0003879_abnormal_hair_cell1.09629222
69MP0002254_reproductive_system_inflammat1.07066186
70MP0003221_abnormal_cardiomyocyte_apopto1.06904589
71MP0000343_altered_response_to1.05432299
72MP0005666_abnormal_adipose_tissue1.04118240
73MP0003690_abnormal_glial_cell1.02531999
74MP0001661_extended_life_span1.02120075
75MP0005388_respiratory_system_phenotype1.01876381
76MP0002133_abnormal_respiratory_system1.01876381
77MP0003279_aneurysm0.99997296
78MP0000534_abnormal_ureter_morphology0.99829554
79MP0001299_abnormal_eye_distance/0.99596323
80MP0000566_synostosis0.99477212
81MP0004510_myositis0.95406049
82MP0001486_abnormal_startle_reflex0.94309645
83MP0000767_abnormal_smooth_muscle0.87793220
84MP0005375_adipose_tissue_phenotype0.87792620
85MP0000266_abnormal_heart_morphology0.86092316
86MP0002249_abnormal_larynx_morphology0.85822110
87MP0002822_catalepsy0.85449288
88MP0004859_abnormal_synaptic_plasticity0.85222479
89MP0000762_abnormal_tongue_morphology0.84875680
90MP0002272_abnormal_nervous_system0.83461089
91MP0003567_abnormal_fetal_cardiomyocyte0.83250436
92MP0004885_abnormal_endolymph0.83014088
93MP0002734_abnormal_mechanical_nocicepti0.82232632
94MP0001502_abnormal_circadian_rhythm0.82124231
95MP0003329_amyloid_beta_deposits0.80091498
96MP0003878_abnormal_ear_physiology0.79979164
97MP0005377_hearing/vestibular/ear_phenot0.79979164
98MP0000230_abnormal_systemic_arterial0.79795977
99MP0002128_abnormal_blood_circulation0.77817857
100MP0005595_abnormal_vascular_smooth0.77721571
101MP0003941_abnormal_skin_development0.77207593
102MP0002909_abnormal_adrenal_gland0.77083221
103MP0008569_lethality_at_weaning0.76444673
104MP0002108_abnormal_muscle_morphology0.76203650
105MP0005248_abnormal_Harderian_gland0.75883761
106MP0000678_abnormal_parathyroid_gland0.74492472
107MP0003635_abnormal_synaptic_transmissio0.72357194
108MP0000003_abnormal_adipose_tissue0.71720880
109MP0002638_abnormal_pupillary_reflex0.71007516
110MP0001765_abnormal_ion_homeostasis0.70519486
111MP0003718_maternal_effect0.70458061
112MP0003191_abnormal_cellular_cholesterol0.69713127
113MP0005423_abnormal_somatic_nervous0.68619213
114MP0000462_abnormal_digestive_system0.67575389
115MP0002925_abnormal_cardiovascular_devel0.66805172
116MP0005187_abnormal_penis_morphology0.65480809
117MP0006036_abnormal_mitochondrial_physio0.65289486
118MP0008961_abnormal_basal_metabolism0.64756472
119MP0003119_abnormal_digestive_system0.63022776
120MP0001963_abnormal_hearing_physiology0.62460786
121MP0003045_fibrosis0.62028294
122MP0001177_atelectasis0.61265832
123MP0001756_abnormal_urination0.60882272
124MP0000013_abnormal_adipose_tissue0.59976341
125MP0002971_abnormal_brown_adipose0.59949373
126MP0002735_abnormal_chemical_nociception0.59838775
127MP0009250_abnormal_appendicular_skeleto0.58898070
128MP0000026_abnormal_inner_ear0.58854635
129MP0001485_abnormal_pinna_reflex0.58841919
130MP0000579_abnormal_nail_morphology0.58079114
131MP0002896_abnormal_bone_mineralization0.57091657
132MP0002098_abnormal_vibrissa_morphology0.56306737
133MP0002063_abnormal_learning/memory/cond0.53744522
134MP0000778_abnormal_nervous_system0.52633190
135MP0001614_abnormal_blood_vessel0.52477779
136MP0003937_abnormal_limbs/digits/tail_de0.51502339
137MP0000920_abnormal_myelination0.50396573
138MP0002064_seizures0.47797409
139MP0003935_abnormal_craniofacial_develop0.45945539

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.44258047
2Nemaline bodies (HP:0003798)7.21019117
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.13233530
4Sudden death (HP:0001699)6.12133336
5Ventricular tachycardia (HP:0004756)5.05019799
6Right ventricular cardiomyopathy (HP:0011663)5.02870888
7Muscle fiber splitting (HP:0003555)4.97145187
8Hyporeflexia of lower limbs (HP:0002600)4.83008415
9Exercise-induced myalgia (HP:0003738)4.52410847
10Calf muscle hypertrophy (HP:0008981)4.52389523
11Exercise-induced muscle cramps (HP:0003710)4.39985136
12Distal arthrogryposis (HP:0005684)4.35205360
13Atrial fibrillation (HP:0005110)4.26665487
14Muscle hypertrophy of the lower extremities (HP:0008968)4.23595455
15Syncope (HP:0001279)4.08652045
16Abnormality of the calf musculature (HP:0001430)4.05784099
17Centrally nucleated skeletal muscle fibers (HP:0003687)4.02392140
18Primary atrial arrhythmia (HP:0001692)3.98733621
19Ventricular fibrillation (HP:0001663)3.87343746
20Supraventricular arrhythmia (HP:0005115)3.81235733
21Supraventricular tachycardia (HP:0004755)3.79955052
22Myopathic facies (HP:0002058)3.74221529
23Prolonged QT interval (HP:0001657)3.70298187
24Round ear (HP:0100830)3.56327548
25Lipoatrophy (HP:0100578)3.54898951
26Bundle branch block (HP:0011710)3.43477984
27Difficulty running (HP:0009046)3.42475734
28Asymmetric septal hypertrophy (HP:0001670)3.41542377
29Ventricular arrhythmia (HP:0004308)3.39013998
30Goiter (HP:0000853)3.38215479
31Increased connective tissue (HP:0009025)3.33723239
32EMG: myopathic abnormalities (HP:0003458)3.28596870
33Hip contracture (HP:0003273)3.21503094
34Subaortic stenosis (HP:0001682)3.19292753
35Abnormality of the left ventricular outflow tract (HP:0011103)3.19292753
36Rimmed vacuoles (HP:0003805)3.18783744
37Palpitations (HP:0001962)3.15645573
38Myoglobinuria (HP:0002913)3.15445176
39Hyperactive renin-angiotensin system (HP:0000841)3.14998471
40Areflexia of lower limbs (HP:0002522)3.01800531
41Myotonia (HP:0002486)2.93527774
42Dilated cardiomyopathy (HP:0001644)2.89943752
43Difficulty climbing stairs (HP:0003551)2.82427938
44Onycholysis (HP:0001806)2.78151236
45Broad metatarsal (HP:0001783)2.73313614
46Pili torti (HP:0003777)2.71608954
47Type 1 muscle fiber predominance (HP:0003803)2.68974343
48Heart block (HP:0012722)2.68264574
49Increased variability in muscle fiber diameter (HP:0003557)2.66295826
50Ulnar deviation of the wrist (HP:0003049)2.66271130
51Hyperkalemia (HP:0002153)2.65742967
52Limited hip movement (HP:0008800)2.65110118
53Abnormal atrioventricular conduction (HP:0005150)2.58697056
54Abnormal EKG (HP:0003115)2.57510107
55Polycythemia (HP:0001901)2.57382611
56Calcaneovalgus deformity (HP:0001848)2.57242409
57Interstitial pulmonary disease (HP:0006530)2.56038887
58Atrioventricular block (HP:0001678)2.55234233
59Mildly elevated creatine phosphokinase (HP:0008180)2.54797089
60Absent phalangeal crease (HP:0006109)2.54326656
61Frequent falls (HP:0002359)2.48779993
62Distal lower limb muscle weakness (HP:0009053)2.41949191
63Chronic bronchitis (HP:0004469)2.37823224
64Abnormality of skeletal muscle fiber size (HP:0012084)2.26917128
65Decreased circulating renin level (HP:0003351)2.21593896
66Deformed tarsal bones (HP:0008119)2.14858801
67Generalized muscle weakness (HP:0003324)2.13374795
68Renal salt wasting (HP:0000127)2.12815897
69Pulmonary artery stenosis (HP:0004415)2.12352199
70Visceral angiomatosis (HP:0100761)2.12339858
71Foot dorsiflexor weakness (HP:0009027)2.11557316
72Malignant hyperthermia (HP:0002047)2.11528810
73Muscle stiffness (HP:0003552)2.10337368
74Abnormality of the foot musculature (HP:0001436)2.10279181
75Neck muscle weakness (HP:0000467)2.08995284
76Hyperaldosteronism (HP:0000859)2.07543242
77Scapular winging (HP:0003691)2.06964216
78Rectal prolapse (HP:0002035)2.06648582
79Palmoplantar keratoderma (HP:0000982)2.06014153
80Cerebral aneurysm (HP:0004944)2.04095811
81Steppage gait (HP:0003376)2.03765309
82Hypoplastic ischia (HP:0003175)2.03077910
83Proximal amyotrophy (HP:0007126)2.00207482
84Limb-girdle muscle atrophy (HP:0003797)1.98960388
85Facial diplegia (HP:0001349)1.95528233
86Rapidly progressive (HP:0003678)1.95518120
87Aplasia involving bones of the upper limbs (HP:0009823)1.94999272
88Aplasia of the phalanges of the hand (HP:0009802)1.94999272
89Aplasia involving bones of the extremities (HP:0009825)1.94999272
90Rhabdomyolysis (HP:0003201)1.94252299
91Abnormal finger flexion creases (HP:0006143)1.94028171
92Hypoplastic left heart (HP:0004383)1.92829666
93Abnormality of the ischium (HP:0003174)1.91999750
94Sudden cardiac death (HP:0001645)1.90910290
95Long toe (HP:0010511)1.90899897
96Hemangiomatosis (HP:0007461)1.90849798
97Spinal rigidity (HP:0003306)1.89241514
98Respiratory distress (HP:0002098)1.88605014
99Bulbar palsy (HP:0001283)1.87709360
100Diaphragmatic weakness (HP:0009113)1.87077656
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86807117
102Cerebral hemorrhage (HP:0001342)1.86151789
103Fetal akinesia sequence (HP:0001989)1.86026188
104Hematochezia (HP:0002573)1.85983207
105Obstructive sleep apnea (HP:0002870)1.85737809
106Atrophic scars (HP:0001075)1.85697954
107Milia (HP:0001056)1.85134166
108Abnormality of the vocal cords (HP:0008777)1.84865799
109Tachypnea (HP:0002789)1.84091615
110Abnormality of chloride homeostasis (HP:0011422)1.81592971
111Weak cry (HP:0001612)1.81385048
112Maternal diabetes (HP:0009800)1.80814312
113Fragile nails (HP:0001808)1.80425377
114Mesangial abnormality (HP:0001966)1.75927060
115Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.75223637
116Congenital malformation of the right heart (HP:0011723)1.75125416
117Double outlet right ventricle (HP:0001719)1.75125416
118Partial duplication of thumb phalanx (HP:0009944)1.74854960
119Muscular dystrophy (HP:0003560)1.73133408
120EMG: neuropathic changes (HP:0003445)1.72808316
121Abnormality of the salivary glands (HP:0010286)1.72498427
122Neurofibrillary tangles (HP:0002185)1.71501187
123Gowers sign (HP:0003391)1.71196058
124Nonprogressive disorder (HP:0003680)1.70458801
125Bronchomalacia (HP:0002780)1.70273023
126Abnormality of the shoulder girdle musculature (HP:0001435)1.70185375
127Waddling gait (HP:0002515)1.69998179
128Conjunctival hamartoma (HP:0100780)1.69933599
129Left ventricular hypertrophy (HP:0001712)1.66904397
130Hypoplastic heart (HP:0001961)1.66626244
131Short hallux (HP:0010109)1.66170694
132Skin pits (HP:0100276)1.65424751
133Abnormality of renin-angiotensin system (HP:0000847)1.65072093
134Distal lower limb amyotrophy (HP:0008944)1.61371770
135Aplasia of the musculature (HP:0100854)1.60115011
136Choanal stenosis (HP:0000452)1.57507654
137Dysmetric saccades (HP:0000641)1.56751198
138Metatarsus adductus (HP:0001840)1.56397910
139Lower limb amyotrophy (HP:0007210)1.55516450
140Ulnar deviation of finger (HP:0009465)1.51100376
141Dysdiadochokinesis (HP:0002075)1.47377819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.33008801
2TTN3.70503108
3MYLK3.54024201
4TIE13.48688157
5PHKG13.14897524
6PHKG23.14897524
7TRIB32.90378733
8DMPK2.35553850
9OBSCN2.35253993
10PDK32.21494416
11PDK42.21494416
12PDK21.84216743
13STK241.84055849
14RIPK11.81161536
15TGFBR21.79047061
16PKN21.73979285
17FER1.65990532
18NTRK31.59684752
19MARK11.56494205
20TNIK1.55755272
21EEF2K1.54577541
22EPHB11.50038175
23STK391.47284631
24NTRK21.46430804
25FGFR21.44528466
26EPHB21.38746449
27PINK11.36808289
28DDR21.31422190
29PAK31.31384304
30WNK41.30241717
31BCKDK1.27541011
32PRKD11.25945666
33ILK1.22198127
34MAP3K31.20543694
35KSR21.19971257
36PIK3CA1.19636093
37PDGFRA1.17945567
38MAPKAPK31.17409719
39AKT31.13736754
40NEK61.09791670
41ROCK11.08769964
42MAP3K71.07161850
43LRRK21.03192533
44LATS11.02254622
45MAPK151.01792476
46PRKD31.00609709
47CDC42BPA0.98111665
48TRPM70.97253443
49PTK2B0.96998076
50CAMK2B0.95022624
51MAP3K20.93680951
52STK38L0.93481662
53MAP3K130.92244582
54PTK60.90575935
55NEK10.88936851
56ROCK20.88276426
57SGK20.87228418
58PIK3CG0.86889896
59MST40.83588768
60MAP2K20.82842977
61DAPK20.82775210
62ARAF0.81932510
63TYRO30.81125167
64LATS20.79959792
65WNK10.79868593
66MAPK70.79304914
67STK380.78296914
68FLT30.77027358
69SGK4940.77011071
70SGK2230.77011071
71CAMK2D0.76928975
72RET0.75535576
73MAP3K10.75341365
74MAPK120.75201904
75ICK0.74701116
76LIMK10.74437658
77TESK10.74285800
78MOS0.72581168
79EPHA40.70998551
80DAPK30.70546040
81NTRK10.70315616
82GRK70.70183567
83CAMK40.69281106
84MAPK100.68432618
85SGK30.67599330
86ERN10.67328027
87SIK10.66216201
88NEK90.64330888
89PDPK10.63943401
90AKT20.62301330
91UHMK10.60702804
92MUSK0.60693006
93RPS6KA20.60575327
94PRKG10.59648645
95MET0.59593369
96PRKG20.59158651
97MAP2K10.57255209
98PAK40.55807829
99PRKAA10.54560837
100PTK20.53928613
101MTOR0.53022264
102MAPK40.52940125
103CASK0.52693463
104PDGFRB0.51416246
105GRK50.51340701
106CAMK2A0.50833129
107PRKAA20.50318091
108MAP2K30.50163669
109PRKCE0.50017821
110PAK60.48512740
111SGK10.48436754
112MAP2K40.47250206
113PNCK0.45386005
114NME10.44470970
115KDR0.44353189
116CDK50.43359473
117PRKACB0.42854180
118CAMK1G0.42784609
119NLK0.41866994
120TAOK10.41840411
121MAPKAPK50.41513248
122MAPK130.40587273
123PKN10.40144991
124PRKCH0.39504097
125RPS6KA30.38896640
126CAMK2G0.38881763
127CAMK1D0.37919746
128RPS6KL10.37469835
129RPS6KC10.37469835
130FGFR10.36878722
131PAK20.36293302
132CAMK10.33673302
133PRKACA0.33304376
134MARK20.33205888
135MAP3K90.32843703
136GRK10.32726156
137DYRK1B0.32720239
138MELK0.31375653
139CSNK1G10.31039098
140RPS6KB10.30846875
141TNK20.26288665
142CSNK1D0.25096195
143RPS6KA10.23878542

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.15123148
2Cardiac muscle contraction_Homo sapiens_hsa042602.89530071
3Dilated cardiomyopathy_Homo sapiens_hsa054142.80876751
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.72841703
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26359266
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16801554
7Propanoate metabolism_Homo sapiens_hsa006401.87050253
8ECM-receptor interaction_Homo sapiens_hsa045121.85137576
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.80191996
10Fatty acid degradation_Homo sapiens_hsa000711.78598813
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69573694
12Thyroid hormone synthesis_Homo sapiens_hsa049181.51822579
13Fatty acid metabolism_Homo sapiens_hsa012121.48737677
14Gastric acid secretion_Homo sapiens_hsa049711.48162544
15Tight junction_Homo sapiens_hsa045301.46334275
16Oxidative phosphorylation_Homo sapiens_hsa001901.44432047
17Parkinsons disease_Homo sapiens_hsa050121.42383618
18Focal adhesion_Homo sapiens_hsa045101.40575226
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37375675
20Renin secretion_Homo sapiens_hsa049241.34278361
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31843404
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30464578
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.30407158
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27997698
25Alzheimers disease_Homo sapiens_hsa050101.27057872
26Fatty acid biosynthesis_Homo sapiens_hsa000611.25930706
27Histidine metabolism_Homo sapiens_hsa003401.25880494
28Mineral absorption_Homo sapiens_hsa049781.23676618
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22752405
30Long-term potentiation_Homo sapiens_hsa047201.18581929
31Dorso-ventral axis formation_Homo sapiens_hsa043201.16008930
32Fatty acid elongation_Homo sapiens_hsa000621.15533262
33Carbon metabolism_Homo sapiens_hsa012001.09278952
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09126803
35Protein digestion and absorption_Homo sapiens_hsa049741.09092587
36Autoimmune thyroid disease_Homo sapiens_hsa053201.08775898
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07232030
38Adherens junction_Homo sapiens_hsa045201.04941881
39Amoebiasis_Homo sapiens_hsa051461.03869336
40Arginine biosynthesis_Homo sapiens_hsa002201.03017618
41Pyruvate metabolism_Homo sapiens_hsa006201.01518449
42beta-Alanine metabolism_Homo sapiens_hsa004100.97921748
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95213260
44Salivary secretion_Homo sapiens_hsa049700.95037908
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94424741
46Viral myocarditis_Homo sapiens_hsa054160.94389068
47Glutamatergic synapse_Homo sapiens_hsa047240.94227204
48Pancreatic secretion_Homo sapiens_hsa049720.93207395
49Taste transduction_Homo sapiens_hsa047420.89256278
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88619188
51Amphetamine addiction_Homo sapiens_hsa050310.86220454
52Oxytocin signaling pathway_Homo sapiens_hsa049210.84312911
53Sulfur metabolism_Homo sapiens_hsa009200.84300411
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.82968568
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82346587
56Hippo signaling pathway_Homo sapiens_hsa043900.81464330
57Insulin resistance_Homo sapiens_hsa049310.79425916
58Phenylalanine metabolism_Homo sapiens_hsa003600.79130097
59PPAR signaling pathway_Homo sapiens_hsa033200.78925570
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78362325
61Renal cell carcinoma_Homo sapiens_hsa052110.77814839
62Huntingtons disease_Homo sapiens_hsa050160.77535432
63Wnt signaling pathway_Homo sapiens_hsa043100.77400164
64cAMP signaling pathway_Homo sapiens_hsa040240.75162093
65Oocyte meiosis_Homo sapiens_hsa041140.75136915
66Insulin signaling pathway_Homo sapiens_hsa049100.74558239
67GnRH signaling pathway_Homo sapiens_hsa049120.74523480
68Calcium signaling pathway_Homo sapiens_hsa040200.73968015
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73880519
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73804621
71VEGF signaling pathway_Homo sapiens_hsa043700.73095467
72Bile secretion_Homo sapiens_hsa049760.71512673
73Insulin secretion_Homo sapiens_hsa049110.69799236
74Proteoglycans in cancer_Homo sapiens_hsa052050.69000126
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68731847
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.68228988
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66623259
78Glucagon signaling pathway_Homo sapiens_hsa049220.64934848
79Lysine degradation_Homo sapiens_hsa003100.64777160
80Notch signaling pathway_Homo sapiens_hsa043300.64133094
81AMPK signaling pathway_Homo sapiens_hsa041520.63978415
82Circadian entrainment_Homo sapiens_hsa047130.63801337
83Long-term depression_Homo sapiens_hsa047300.63095138
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.62849078
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.62510894
86Endometrial cancer_Homo sapiens_hsa052130.62413678
87Morphine addiction_Homo sapiens_hsa050320.62221604
88Melanogenesis_Homo sapiens_hsa049160.62099937
89Estrogen signaling pathway_Homo sapiens_hsa049150.59588655
90Thyroid cancer_Homo sapiens_hsa052160.58852427
91Small cell lung cancer_Homo sapiens_hsa052220.57628512
92Ovarian steroidogenesis_Homo sapiens_hsa049130.57030162
93Nitrogen metabolism_Homo sapiens_hsa009100.56356427
94Pentose phosphate pathway_Homo sapiens_hsa000300.55517346
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55344524
96Hedgehog signaling pathway_Homo sapiens_hsa043400.55237433
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54596269
98Sulfur relay system_Homo sapiens_hsa041220.54292628
99Lysosome_Homo sapiens_hsa041420.54173394
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54090955
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.53541794
102Rap1 signaling pathway_Homo sapiens_hsa040150.53289990
103Dopaminergic synapse_Homo sapiens_hsa047280.53253167
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53069847
105Axon guidance_Homo sapiens_hsa043600.52869927
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52730517
107TGF-beta signaling pathway_Homo sapiens_hsa043500.52393016
108Gap junction_Homo sapiens_hsa045400.52346450
109Nicotine addiction_Homo sapiens_hsa050330.50966856
110Starch and sucrose metabolism_Homo sapiens_hsa005000.50071108
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50069242
112Serotonergic synapse_Homo sapiens_hsa047260.49977114
113MAPK signaling pathway_Homo sapiens_hsa040100.49966504
114Inositol phosphate metabolism_Homo sapiens_hsa005620.49417806
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47547780
116Basal cell carcinoma_Homo sapiens_hsa052170.47372610
117Biosynthesis of amino acids_Homo sapiens_hsa012300.46007168
118HIF-1 signaling pathway_Homo sapiens_hsa040660.45645724
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45579561
120Vibrio cholerae infection_Homo sapiens_hsa051100.45191329
121Type II diabetes mellitus_Homo sapiens_hsa049300.44927267
122Circadian rhythm_Homo sapiens_hsa047100.44787901
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44763516
124Bladder cancer_Homo sapiens_hsa052190.42928419
125Endocytosis_Homo sapiens_hsa041440.41605163
126Cholinergic synapse_Homo sapiens_hsa047250.41586208
127Arginine and proline metabolism_Homo sapiens_hsa003300.40473069
128Tyrosine metabolism_Homo sapiens_hsa003500.40408943
129GABAergic synapse_Homo sapiens_hsa047270.38069596
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37640932
131Butanoate metabolism_Homo sapiens_hsa006500.37206387
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36719267
133Platelet activation_Homo sapiens_hsa046110.36385837
134Ras signaling pathway_Homo sapiens_hsa040140.36270763
135Tryptophan metabolism_Homo sapiens_hsa003800.36038697

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