FAM189B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)6.42062490
2detection of temperature stimulus involved in sensory perception (GO:0050961)6.42062490
3detection of temperature stimulus (GO:0016048)6.21722809
4negative regulation of dendrite morphogenesis (GO:0050774)5.16321742
5neurofilament cytoskeleton organization (GO:0060052)5.06113882
6neuronal action potential (GO:0019228)5.04689012
7regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.02796160
8negative regulation of calcium ion transport into cytosol (GO:0010523)4.99017514
9peripheral nervous system neuron development (GO:0048935)4.88629149
10sequestering of actin monomers (GO:0042989)4.75969186
11behavioral response to pain (GO:0048266)4.57509069
12negative regulation of microtubule polymerization (GO:0031115)4.49932050
13synaptic vesicle maturation (GO:0016188)4.37300219
14response to pain (GO:0048265)4.33097854
15positive regulation of synaptic transmission, GABAergic (GO:0032230)4.32019884
16heterochromatin organization (GO:0070828)4.20415759
17regulation of isotype switching to IgG isotypes (GO:0048302)4.19890970
18membrane depolarization during action potential (GO:0086010)4.16293062
19negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.14649142
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08456415
21ribosomal small subunit biogenesis (GO:0042274)4.07710484
22neuronal action potential propagation (GO:0019227)4.04278794
23negative regulation of cell killing (GO:0031342)3.96889253
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96889253
25cell migration in hindbrain (GO:0021535)3.88364565
26positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.88096075
27maturation of SSU-rRNA (GO:0030490)3.86393443
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83026075
29potassium ion export (GO:0071435)3.74951977
30proline transport (GO:0015824)3.73979294
31negative T cell selection (GO:0043383)3.73971636
32regulation of synaptic vesicle exocytosis (GO:2000300)3.71483250
33negative thymic T cell selection (GO:0045060)3.60622649
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.60319950
35synaptic vesicle exocytosis (GO:0016079)3.59284236
36outer ear morphogenesis (GO:0042473)3.58773982
37regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56458410
38glutamate secretion (GO:0014047)3.55971203
39axon cargo transport (GO:0008088)3.47625449
40negative regulation of dendrite development (GO:2000171)3.47611685
41urinary tract smooth muscle contraction (GO:0014848)3.46460381
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41005283
43cochlea morphogenesis (GO:0090103)3.37835426
44neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.33843211
45phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.33801709
46sodium ion export (GO:0071436)3.32687220
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.31549002
48lymph vessel development (GO:0001945)3.26568740
49positive thymic T cell selection (GO:0045059)3.25141581
50regulation of defense response to virus by virus (GO:0050690)3.25079400
51positive T cell selection (GO:0043368)3.23302263
52regulation of synaptic vesicle transport (GO:1902803)3.21994625
53cellular potassium ion homeostasis (GO:0030007)3.20399435
54convergent extension (GO:0060026)3.19224205
55thymic T cell selection (GO:0045061)3.18182269
56adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.17519931
57Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.17072723
58UTP biosynthetic process (GO:0006228)3.16263115
59nuclear envelope reassembly (GO:0031468)3.12642228
60mitotic nuclear envelope reassembly (GO:0007084)3.12642228
61regulation of apoptotic process involved in morphogenesis (GO:1902337)3.11327477
62viral transcription (GO:0019083)3.10287345
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09708572
64dorsal/ventral neural tube patterning (GO:0021904)3.08763201
65enteric nervous system development (GO:0048484)3.05395261
66pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03420885
67membrane repolarization (GO:0086009)3.02070537
68protein localization to synapse (GO:0035418)3.01947932
69neuromuscular synaptic transmission (GO:0007274)3.00422216
70response to interleukin-15 (GO:0070672)3.00189490
71cellular response to interleukin-15 (GO:0071350)2.99989325
72negative regulation of protein polymerization (GO:0032272)2.99680505
73pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.97079025
74regulation of translational fidelity (GO:0006450)2.96350530
75peptidyl-arginine omega-N-methylation (GO:0035247)2.95048292
76regulation of establishment of planar polarity (GO:0090175)2.94362386
77dopamine receptor signaling pathway (GO:0007212)2.94215795
78positive regulation of potassium ion transmembrane transport (GO:1901381)2.93882336
79negative regulation of immunoglobulin mediated immune response (GO:0002890)2.92888763
80negative regulation of B cell mediated immunity (GO:0002713)2.92888763
81translational termination (GO:0006415)2.91288670
82sulfur amino acid catabolic process (GO:0000098)2.90177590
83regulation of amyloid precursor protein catabolic process (GO:1902991)2.90070247
84cellular response to nicotine (GO:0071316)2.88334494
85negative regulation of type 2 immune response (GO:0002829)2.88249275
86DNA replication checkpoint (GO:0000076)2.86500789
87activation of protein kinase A activity (GO:0034199)2.86472406
88leukocyte aggregation (GO:0070486)2.86372982
89mammary gland epithelial cell differentiation (GO:0060644)2.86324895
90diaphragm development (GO:0060539)2.85715035
91retinal ganglion cell axon guidance (GO:0031290)2.85359594
92T cell selection (GO:0045058)2.85163846
93UTP metabolic process (GO:0046051)2.83649270
94T cell receptor signaling pathway (GO:0050852)2.82194774
95negative regulation of actin filament polymerization (GO:0030837)2.81994015
96T cell migration (GO:0072678)2.80059884
97tooth mineralization (GO:0034505)2.79366074
98embryonic skeletal joint morphogenesis (GO:0060272)2.78975592
99translational elongation (GO:0006414)2.77272038
100multicellular organismal response to stress (GO:0033555)2.76751900
101muscle cell fate commitment (GO:0042693)2.76456872
102positive regulation of gamma-delta T cell activation (GO:0046645)2.75965543
103pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.74057459
104skeletal muscle organ development (GO:0060538)2.73360530
105pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.73187708
106actin filament capping (GO:0051693)2.72989419
107cranial nerve morphogenesis (GO:0021602)2.72807455
108glycosphingolipid biosynthetic process (GO:0006688)2.70800906
109regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.70694615
110positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.70694615
111establishment of mitochondrion localization (GO:0051654)2.70560661
112response to water (GO:0009415)2.70158367
113GTP biosynthetic process (GO:0006183)2.69713511
114outflow tract septum morphogenesis (GO:0003148)2.67919137
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67481032
116peristalsis (GO:0030432)2.66930113
117cerebellar Purkinje cell differentiation (GO:0021702)2.65487843
118establishment of apical/basal cell polarity (GO:0035089)2.65028633
119mast cell degranulation (GO:0043303)2.64842737
120mast cell activation involved in immune response (GO:0002279)2.64842737
121proline biosynthetic process (GO:0006561)2.64267996
122rRNA transcription (GO:0009303)2.63804518
123CTP biosynthetic process (GO:0006241)2.63092005
124CTP metabolic process (GO:0046036)2.63092005
125positive regulation of calcium-mediated signaling (GO:0050850)2.62974566
126protein insertion into membrane (GO:0051205)2.62237073
127negative regulation of heart rate (GO:0010459)2.61336964
128synaptic vesicle docking involved in exocytosis (GO:0016081)2.60090244
129establishment or maintenance of monopolar cell polarity (GO:0061339)2.59566679
130establishment of monopolar cell polarity (GO:0061162)2.59566679
131organelle transport along microtubule (GO:0072384)2.59398332
132activated T cell proliferation (GO:0050798)2.58542063
133sensory perception of pain (GO:0019233)2.58009908
134positive regulation of lamellipodium assembly (GO:0010592)2.57253044
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56759990
136cell communication involved in cardiac conduction (GO:0086065)2.56620463
137mitotic G1 DNA damage checkpoint (GO:0031571)2.56299914
138innervation (GO:0060384)2.56256535
139chromatin assembly (GO:0031497)2.56121151
140mast cell activation (GO:0045576)2.56025828
141mitochondrion transport along microtubule (GO:0047497)2.55889765
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55889765
143detection of mechanical stimulus involved in sensory perception (GO:0050974)2.55299953
144positive regulation of DNA-dependent DNA replication (GO:2000105)2.54875206
145DNA unwinding involved in DNA replication (GO:0006268)2.54613227
146neuron cell-cell adhesion (GO:0007158)2.54427261
147regulation of stem cell maintenance (GO:2000036)2.54140547
148negative regulation of cation channel activity (GO:2001258)2.53622182
149guanosine-containing compound biosynthetic process (GO:1901070)2.53458518
150negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.53353079
151pseudouridine synthesis (GO:0001522)2.53054837
152response to ATP (GO:0033198)2.52109153
153positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.51230489
154action potential (GO:0001508)2.50822948
155nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50426688
156RNA localization (GO:0006403)2.49435288
157histone arginine methylation (GO:0034969)2.47556173
158peptidyl-arginine N-methylation (GO:0035246)2.45972779
159peptidyl-arginine methylation (GO:0018216)2.45972779
160positive regulation of histone deacetylation (GO:0031065)2.45909742
161SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45637762
162non-canonical Wnt signaling pathway (GO:0035567)2.44836015
163neuron projection extension involved in neuron projection guidance (GO:1902284)2.43072110
164axon extension involved in axon guidance (GO:0048846)2.43072110
165positive regulation of triglyceride biosynthetic process (GO:0010867)2.42484424
166tRNA methylation (GO:0030488)2.40309232
167cotranslational protein targeting to membrane (GO:0006613)2.39241367
168protein targeting to ER (GO:0045047)2.38588922
169viral life cycle (GO:0019058)2.35279319
170L-serine metabolic process (GO:0006563)2.35264056
171mitotic G1/S transition checkpoint (GO:0044819)2.34722067
172protein-DNA complex disassembly (GO:0032986)2.34399098
173nucleosome disassembly (GO:0006337)2.34399098
174regulation of translational termination (GO:0006449)2.33335755
175protein complex disassembly (GO:0043241)2.32906186
176cellular protein complex disassembly (GO:0043624)2.31803292
177neuron fate specification (GO:0048665)2.31200673
178negative regulation of cell aging (GO:0090344)2.29442798
179ribosomal small subunit assembly (GO:0000028)2.29238365
180positive regulation of transcription regulatory region DNA binding (GO:2000679)2.28824833
181embryonic skeletal system morphogenesis (GO:0048704)2.27609359
182translational initiation (GO:0006413)2.27331882
183thyroid gland development (GO:0030878)2.26979382
184embryonic viscerocranium morphogenesis (GO:0048703)2.26591358
185DNA replication initiation (GO:0006270)2.25936379
186positive regulation of muscle cell apoptotic process (GO:0010661)2.25747795
187negative regulation of telomerase activity (GO:0051974)2.24846291
188ribonucleoprotein complex biogenesis (GO:0022613)2.24198457
189negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.24142070
190regulation of heart morphogenesis (GO:2000826)2.23982726
191DNA damage induced protein phosphorylation (GO:0006975)2.23541134
192middle ear morphogenesis (GO:0042474)2.23377680
193ATP synthesis coupled proton transport (GO:0015986)2.22938429
194energy coupled proton transport, down electrochemical gradient (GO:0015985)2.22938429
195mitotic sister chromatid segregation (GO:0000070)2.22563876
196protein heterotrimerization (GO:0070208)2.22103043
197establishment of protein localization to endoplasmic reticulum (GO:0072599)2.21824615
198regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.20963503
199spinal cord development (GO:0021510)2.20305428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94877199
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.58341423
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93639242
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90843161
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.57311612
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.55811540
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41604667
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40082045
9* XRN2_22483619_ChIP-Seq_HELA_Human2.37568490
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32550921
11E2F7_22180533_ChIP-Seq_HELA_Human2.32390856
12REST_21632747_ChIP-Seq_MESCs_Mouse2.31512590
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31056998
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26518689
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.23799853
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.23352942
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21832971
18RUNX_20019798_ChIP-Seq_JUKART_Human2.14504178
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14290360
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.14055295
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11614337
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10424529
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09168652
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09168652
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.04590838
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00538299
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99958026
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97928628
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.97726006
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97347230
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96719393
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94113804
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.88992946
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.88671066
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.86961265
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84039179
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83275907
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.83091648
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82958600
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81874954
41RACK7_27058665_Chip-Seq_MCF-7_Human1.81119426
42* KDM2B_26808549_Chip-Seq_DND41_Human1.79299865
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78724378
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.77393999
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76053581
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75840995
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.73661626
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73656754
49* TTF2_22483619_ChIP-Seq_HELA_Human1.73113276
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.72152385
51* MYC_22102868_ChIP-Seq_BL_Human1.71858631
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70819173
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70786070
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70540879
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70003418
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69097087
57VDR_21846776_ChIP-Seq_THP-1_Human1.68669714
58MAF_26560356_Chip-Seq_TH1_Human1.67715155
59UTX_26944678_Chip-Seq_JUKART_Human1.66048000
60* LXR_22292898_ChIP-Seq_THP-1_Human1.65385036
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64386823
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62571472
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62563923
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.61521919
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.59995714
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58269990
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.58095943
68KDM2B_26808549_Chip-Seq_K562_Human1.57180701
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56622736
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56307454
71* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54662004
72MYB_26560356_Chip-Seq_TH2_Human1.49654615
73* CTCF_27219007_Chip-Seq_Bcells_Human1.49212176
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48985686
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48155578
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47712100
77DROSHA_22980978_ChIP-Seq_HELA_Human1.47562660
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47294191
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44481439
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.44316246
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44017275
82GABP_19822575_ChIP-Seq_HepG2_Human1.41345512
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41010746
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40798750
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40345888
86* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39583216
87* FOXP1_21924763_ChIP-Seq_HESCs_Human1.39018523
88* SA1_27219007_Chip-Seq_ERYTHROID_Human1.38293449
89* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36670240
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36632934
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34323800
92KDM5A_27292631_Chip-Seq_BREAST_Human1.33809175
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32000736
94* SPI1_23127762_ChIP-Seq_K562_Human1.30782513
95* CREB1_26743006_Chip-Seq_LNCaP_Human1.29397058
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.28908937
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.28836546
98* MAF_26560356_Chip-Seq_TH2_Human1.28727288
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28645868
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27845094
101ZNF263_19887448_ChIP-Seq_K562_Human1.26747441
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25811285
103* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25334432
104DCP1A_22483619_ChIP-Seq_HELA_Human1.25067973
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.23615924
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22815373
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.22338431
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.21641083
109* TET1_21490601_ChIP-Seq_MESCs_Mouse1.21187338
110TP53_22127205_ChIP-Seq_IMR90_Human1.20443740
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20243666
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19667788
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.16135841
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15930093
115RARA_24833708_ChIP-Seq_LIVER_Mouse1.14736870
116* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14720374
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12476140
118* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12356525
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11012779
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10856514
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10548042
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.10317345
123SMC4_20622854_ChIP-Seq_HELA_Human1.10059228
124* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09899815
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09431256
126E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08833555
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.08238533
128TCF7_22412390_ChIP-Seq_EML_Mouse1.08016459
129MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07747300
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07700956
131E2F1_20622854_ChIP-Seq_HELA_Human1.07627748
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07004673
133PHF8_20622854_ChIP-Seq_HELA_Human1.06330876
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06231434
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05739383
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04940040
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04890692
138* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04068100
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03094511
140* SA1_27219007_Chip-Seq_Bcells_Human1.02797820
141TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02470266
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01717506
143ATF3_27146783_Chip-Seq_COLON_Human1.01614472
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01578680
145MYB_26560356_Chip-Seq_TH1_Human0.99394604
146EGR1_19032775_ChIP-ChIP_M12_Human0.99184757
147GATA3_27048872_Chip-Seq_THYMUS_Human0.98465319
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98392470
149P68_20966046_ChIP-Seq_HELA_Human0.98370527
150CIITA_25753668_ChIP-Seq_RAJI_Human0.96724711
151VDR_24763502_ChIP-Seq_THP-1_Human0.96541930
152* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96152562
153SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95914825
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.95735761
155AR_21572438_ChIP-Seq_LNCaP_Human0.95263579
156KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92861533
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92567713
158GBX2_23144817_ChIP-Seq_PC3_Human0.90452152
159CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89756895
160ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89727953
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87919469
162BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87728898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.60103767
2MP0001968_abnormal_touch/_nociception6.49382417
3MP0002736_abnormal_nociception_after5.83229657
4MP0010030_abnormal_orbit_morphology4.22340673
5MP0001986_abnormal_taste_sensitivity4.20902467
6MP0002733_abnormal_thermal_nociception3.95710327
7MP0005623_abnormal_meninges_morphology3.81525871
8MP0004270_analgesia3.76983207
9MP0006276_abnormal_autonomic_nervous3.69075725
10MP0004858_abnormal_nervous_system3.48796932
11MP0004859_abnormal_synaptic_plasticity3.47266518
12MP0001970_abnormal_pain_threshold3.46443782
13MP0002734_abnormal_mechanical_nocicepti3.40921736
14MP0002249_abnormal_larynx_morphology3.32584103
15MP0002234_abnormal_pharynx_morphology3.08783672
16MP0000566_synostosis2.95183380
17MP0000678_abnormal_parathyroid_gland2.50995376
18MP0003880_abnormal_central_pattern2.39053678
19MP0000049_abnormal_middle_ear2.37595840
20MP0003635_abnormal_synaptic_transmissio2.30139278
21MP0003705_abnormal_hypodermis_morpholog2.20588728
22MP0003763_abnormal_thymus_physiology2.17914569
23MP0002272_abnormal_nervous_system2.16776371
24MP0003283_abnormal_digestive_organ2.13884426
25MP0009053_abnormal_anal_canal2.12887579
26MP0003693_abnormal_embryo_hatching2.12567125
27MP0001346_abnormal_lacrimal_gland2.11843333
28MP0002184_abnormal_innervation1.97926330
29MP0003942_abnormal_urinary_system1.97763752
30MP0003329_amyloid_beta_deposits1.96666629
31MP0002751_abnormal_autonomic_nervous1.91848065
32MP0009250_abnormal_appendicular_skeleto1.84599380
33MP0002067_abnormal_sensory_capabilities1.82465885
34MP0005423_abnormal_somatic_nervous1.79171505
35MP0009745_abnormal_behavioral_response1.74885588
36MP0006292_abnormal_olfactory_placode1.73512536
37MP0002938_white_spotting1.70469675
38MP0000537_abnormal_urethra_morphology1.68951626
39MP0002877_abnormal_melanocyte_morpholog1.68022989
40MP0004811_abnormal_neuron_physiology1.65823440
41MP0002063_abnormal_learning/memory/cond1.63312017
42MP0002064_seizures1.61876479
43MP0001348_abnormal_lacrimal_gland1.60265456
44MP0000579_abnormal_nail_morphology1.58397603
45MP0005671_abnormal_response_to1.58127285
46MP0003937_abnormal_limbs/digits/tail_de1.57478709
47MP0005076_abnormal_cell_differentiation1.51989052
48MP0008932_abnormal_embryonic_tissue1.51209524
49MP0002163_abnormal_gland_morphology1.47746301
50MP0004233_abnormal_muscle_weight1.45229871
51MP0003111_abnormal_nucleus_morphology1.42654870
52MP0000762_abnormal_tongue_morphology1.40795784
53MP0002572_abnormal_emotion/affect_behav1.40389204
54MP0000955_abnormal_spinal_cord1.38136727
55MP0002822_catalepsy1.37950375
56MP0002697_abnormal_eye_size1.37274825
57MP0000003_abnormal_adipose_tissue1.37225017
58MP0003755_abnormal_palate_morphology1.36060637
59MP0008569_lethality_at_weaning1.35594368
60MP0002932_abnormal_joint_morphology1.33484415
61MP0002116_abnormal_craniofacial_bone1.30079981
62MP0003315_abnormal_perineum_morphology1.27883842
63MP0003123_paternal_imprinting1.27880918
64MP0003385_abnormal_body_wall1.26433037
65MP0003861_abnormal_nervous_system1.22805231
66MP0009046_muscle_twitch1.22651358
67MP0004272_abnormal_basement_membrane1.22003400
68MP0001984_abnormal_olfaction1.19538481
69MP0001270_distended_abdomen1.18107202
70MP0005187_abnormal_penis_morphology1.14771104
71MP0010386_abnormal_urinary_bladder1.14325607
72MP0002085_abnormal_embryonic_tissue1.13076628
73MP0002909_abnormal_adrenal_gland1.12829047
74MP0003935_abnormal_craniofacial_develop1.12489197
75MP0008438_abnormal_cutaneous_collagen1.07275359
76MP0000372_irregular_coat_pigmentation1.06090616
77MP0003938_abnormal_ear_development1.05534388
78MP0003866_abnormal_defecation1.04918654
79MP0005508_abnormal_skeleton_morphology1.04265313
80MP0000733_abnormal_muscle_development1.03688391
81MP0002882_abnormal_neuron_morphology1.03005695
82MP0004133_heterotaxia1.02659463
83MP0002114_abnormal_axial_skeleton1.01389402
84MP0001905_abnormal_dopamine_level0.99583635
85MP0005257_abnormal_intraocular_pressure0.98723544
86MP0002160_abnormal_reproductive_system0.98601243
87MP0003633_abnormal_nervous_system0.96632218
88MP0003045_fibrosis0.95815604
89MP0001730_embryonic_growth_arrest0.94643390
90MP0002177_abnormal_outer_ear0.94511824
91MP0003119_abnormal_digestive_system0.94006916
92MP0000750_abnormal_muscle_regeneration0.93567457
93MP0000681_abnormal_thyroid_gland0.93418902
94MP0004185_abnormal_adipocyte_glucose0.93351764
95MP0000604_amyloidosis0.92954329
96MP0004145_abnormal_muscle_electrophysio0.92258645
97MP0009384_cardiac_valve_regurgitation0.92241986
98MP0001286_abnormal_eye_development0.92177695
99MP0003115_abnormal_respiratory_system0.89630860
100MP0000751_myopathy0.89299526
101MP0008874_decreased_physiological_sensi0.89154307
102MP0001440_abnormal_grooming_behavior0.89101587
103MP0005503_abnormal_tendon_morphology0.88639815
104MP0000013_abnormal_adipose_tissue0.88472325
105MP0002111_abnormal_tail_morphology0.87955910
106MP0002084_abnormal_developmental_patter0.87368863
107MP0005501_abnormal_skin_physiology0.87317661
108MP0002398_abnormal_bone_marrow0.87239715
109MP0000428_abnormal_craniofacial_morphol0.87175012
110MP0003656_abnormal_erythrocyte_physiolo0.86789643
111MP0005670_abnormal_white_adipose0.85499958
112MP0000703_abnormal_thymus_morphology0.85398186
113MP0000467_abnormal_esophagus_morphology0.85028037
114MP0003077_abnormal_cell_cycle0.84348324
115MP0001919_abnormal_reproductive_system0.83881823
116MP0009379_abnormal_foot_pigmentation0.83224991
117MP0000631_abnormal_neuroendocrine_gland0.83110190
118MP0005409_darkened_coat_color0.82792466
119MP0005386_behavior/neurological_phenoty0.81431115
120MP0004924_abnormal_behavior0.81431115
121MP0002557_abnormal_social/conspecific_i0.80756098
122MP0008961_abnormal_basal_metabolism0.80339600
123MP0003122_maternal_imprinting0.80333967
124MP0002098_abnormal_vibrissa_morphology0.80160960
125MP0008872_abnormal_physiological_respon0.79908109
126MP0002066_abnormal_motor_capabilities/c0.78827163
127MP0000432_abnormal_head_morphology0.78410883
128MP0002282_abnormal_trachea_morphology0.77689386
129MP0000350_abnormal_cell_proliferation0.76781624
130MP0000778_abnormal_nervous_system0.76672559
131MP0001502_abnormal_circadian_rhythm0.76525334
132MP0009333_abnormal_splenocyte_physiolog0.75899821
133MP0005379_endocrine/exocrine_gland_phen0.74863091
134MP0001486_abnormal_startle_reflex0.74695295
135MP0005171_absent_coat_pigmentation0.74521293
136MP0004957_abnormal_blastocyst_morpholog0.74430835
137MP0009672_abnormal_birth_weight0.74389363
138MP0001697_abnormal_embryo_size0.74252720
139MP0000685_abnormal_immune_system0.73647162
140MP0002396_abnormal_hematopoietic_system0.73454363
141MP0005197_abnormal_uvea_morphology0.73277075
142MP0000163_abnormal_cartilage_morphology0.73095434
143MP0002081_perinatal_lethality0.72230106
144MP0000534_abnormal_ureter_morphology0.71906752
145MP0001293_anophthalmia0.70710528
146MP0002420_abnormal_adaptive_immunity0.70612050
147MP0002092_abnormal_eye_morphology0.70336602
148MP0005000_abnormal_immune_tolerance0.70158346
149MP0002233_abnormal_nose_morphology0.69893326
150MP0005380_embryogenesis_phenotype0.69674458
151MP0001672_abnormal_embryogenesis/_devel0.69674458
152MP0001501_abnormal_sleep_pattern0.69112696
153MP0001340_abnormal_eyelid_morphology0.69105356
154MP0004142_abnormal_muscle_tone0.69066873
155MP0004197_abnormal_fetal_growth/weight/0.68437967
156MP0000747_muscle_weakness0.68272810
157MP0005375_adipose_tissue_phenotype0.67666779
158MP0000462_abnormal_digestive_system0.67585823
159MP0001819_abnormal_immune_cell0.67447686
160MP0003183_abnormal_peptide_metabolism0.67416418
161MP0003879_abnormal_hair_cell0.66943773
162MP0001299_abnormal_eye_distance/0.65890111
163MP0000749_muscle_degeneration0.64074538
164MP0000716_abnormal_immune_system0.63814680
165MP0005464_abnormal_platelet_physiology0.63760458
166MP0003631_nervous_system_phenotype0.62914471
167MP0002229_neurodegeneration0.61244946
168MP0002723_abnormal_immune_serum0.60738170
169MP0002752_abnormal_somatic_nervous0.60400592
170MP0000920_abnormal_myelination0.59228871
171MP0002405_respiratory_system_inflammati0.58859711
172MP0001800_abnormal_humoral_immune0.58721321
173MP0003634_abnormal_glial_cell0.57756363
174MP0004510_myositis0.57387652
175MP0002722_abnormal_immune_system0.56756808
176MP0002166_altered_tumor_susceptibility0.52553381
177MP0003172_abnormal_lysosome_physiology0.52345834
178MP0010771_integument_phenotype0.51213868
179MP0000858_altered_metastatic_potential0.51050763
180MP0001188_hyperpigmentation0.50256701
181MP0008770_decreased_survivor_rate0.48324838
182MP0002429_abnormal_blood_cell0.47868846
183MP0000689_abnormal_spleen_morphology0.46290163
184MP0002089_abnormal_postnatal_growth/wei0.45253445
185MP0005645_abnormal_hypothalamus_physiol0.43376604
186MP0002873_normal_phenotype0.42947969
187MP0002169_no_abnormal_phenotype0.42785983
188MP0001664_abnormal_digestion0.42279297
189MP0000015_abnormal_ear_pigmentation0.41134284
190MP0005075_abnormal_melanosome_morpholog0.40689917

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.57479097
2Ulnar claw (HP:0001178)6.04332452
3Abnormality of pain sensation (HP:0010832)4.39372294
4Impaired pain sensation (HP:0007328)4.39372294
5Dysautonomia (HP:0002459)4.31125519
6Action tremor (HP:0002345)4.16692838
7Neuroendocrine neoplasm (HP:0100634)3.88034767
8Focal seizures (HP:0007359)3.82117299
9Insidious onset (HP:0003587)3.78744764
10Termporal pattern (HP:0011008)3.78744764
11Pheochromocytoma (HP:0002666)3.73120805
12Atonic seizures (HP:0010819)3.57724476
13Segmental peripheral demyelination/remyelination (HP:0003481)3.56627424
14Ankle clonus (HP:0011448)3.50496746
15Focal motor seizures (HP:0011153)3.45650892
16Supranuclear gaze palsy (HP:0000605)3.40976305
17Hypercortisolism (HP:0001578)3.38796953
18Myotonia (HP:0002486)3.32269699
19Urinary urgency (HP:0000012)3.25403132
20Concave nail (HP:0001598)3.25384194
21Abnormality of the aortic arch (HP:0012303)3.22253203
22Visual hallucinations (HP:0002367)3.20257053
23Febrile seizures (HP:0002373)3.19983978
24Distal arthrogryposis (HP:0005684)3.11307918
25Hammertoe (HP:0001765)3.07208094
26Breast hypoplasia (HP:0003187)3.06897518
27Failure to thrive in infancy (HP:0001531)3.03049363
28Spinal canal stenosis (HP:0003416)3.02969785
29Hypothermia (HP:0002045)2.98688033
30Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.94133973
31Abnormality of the phalanges of the hallux (HP:0010057)2.89563089
32Ulnar bowing (HP:0003031)2.88238847
33Steppage gait (HP:0003376)2.87189720
34Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.84276200
35Hypoventilation (HP:0002791)2.82252828
36Foot dorsiflexor weakness (HP:0009027)2.81551964
37T lymphocytopenia (HP:0005403)2.73963526
38Aplasia/Hypoplasia of the patella (HP:0006498)2.71381169
39Birth length less than 3rd percentile (HP:0003561)2.70903442
40Patellar aplasia (HP:0006443)2.69165163
41Progressive cerebellar ataxia (HP:0002073)2.68307066
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68237120
43Unilateral renal agenesis (HP:0000122)2.65840627
44Abnormal number of incisors (HP:0011064)2.65372819
45Microretrognathia (HP:0000308)2.61881895
46Abnormal autonomic nervous system physiology (HP:0012332)2.61744672
47Broad distal phalanx of finger (HP:0009836)2.60882927
48Septate vagina (HP:0001153)2.57538640
49Abnormality of the foot musculature (HP:0001436)2.55785626
50Renal duplication (HP:0000075)2.55545146
51Neoplasm of the peripheral nervous system (HP:0100007)2.54683247
52Truncal ataxia (HP:0002078)2.49031627
53Abnormality of T cell number (HP:0011839)2.47993868
54Spastic gait (HP:0002064)2.47976858
55Annular pancreas (HP:0001734)2.45547070
56Thoracolumbar scoliosis (HP:0002944)2.45125632
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.44437205
58Shallow orbits (HP:0000586)2.43818574
59Congenital malformation of the right heart (HP:0011723)2.42715315
60Double outlet right ventricle (HP:0001719)2.42715315
61Abnormality of the vocal cords (HP:0008777)2.42233214
62Aplasia/Hypoplasia of the brainstem (HP:0007362)2.40031334
63Hypoplasia of the brainstem (HP:0002365)2.40031334
64Abnormal hair whorl (HP:0010721)2.39334489
65Menstrual irregularities (HP:0000858)2.36561326
66Insomnia (HP:0100785)2.36362964
67Peripheral hypomyelination (HP:0007182)2.33885762
68Abnormal number of erythroid precursors (HP:0012131)2.30859710
69Papilledema (HP:0001085)2.29298752
70Abnormality of cells of the erythroid lineage (HP:0012130)2.27934880
71Protrusio acetabuli (HP:0003179)2.27594448
72Abnormality of magnesium homeostasis (HP:0004921)2.27534665
73Absence seizures (HP:0002121)2.26872748
74Elevated erythrocyte sedimentation rate (HP:0003565)2.26367078
75Hypoplasia of the pons (HP:0012110)2.26150338
76Elfin facies (HP:0004428)2.25974625
77Neuroblastoma (HP:0003006)2.23334055
78Primitive neuroectodermal tumor (HP:0030065)2.23334055
79Neuroblastic tumors (HP:0004376)2.23334055
80Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.23334055
81Abnormal umbilical cord blood vessels (HP:0011403)2.19202337
82Single umbilical artery (HP:0001195)2.19202337
83Abnormality of the fetal cardiovascular system (HP:0010948)2.19202337
84Onion bulb formation (HP:0003383)2.19011402
85Abnormality of the lower motor neuron (HP:0002366)2.18676218
86Bowel diverticulosis (HP:0005222)2.17697094
87Testicular atrophy (HP:0000029)2.16870592
88Pointed chin (HP:0000307)2.16550698
89Hyperthyroidism (HP:0000836)2.16028206
90Type II lissencephaly (HP:0007260)2.15979615
91Long palpebral fissure (HP:0000637)2.15089589
92Stridor (HP:0010307)2.14439070
93Overriding aorta (HP:0002623)2.14301234
94Depression (HP:0000716)2.13757287
95Congenital glaucoma (HP:0001087)2.12175173
96Partial duplication of the phalanx of hand (HP:0009999)2.12044422
97Dialeptic seizures (HP:0011146)2.11051587
98Severe combined immunodeficiency (HP:0004430)2.10760265
99Amblyopia (HP:0000646)2.10746393
100Retinal dysplasia (HP:0007973)2.08460187
101Limb dystonia (HP:0002451)2.05938691
102Distal sensory impairment (HP:0002936)2.05204032
103Slender long bone (HP:0003100)2.04981969
104Hyperacusis (HP:0010780)2.04672789
105Urinary bladder sphincter dysfunction (HP:0002839)2.02093906
106Amyotrophic lateral sclerosis (HP:0007354)2.00277341
107Megalocornea (HP:0000485)1.99770676
108Buphthalmos (HP:0000557)1.98730920
109Progressive inability to walk (HP:0002505)1.97896030
110Overlapping toe (HP:0001845)1.96419650
111Flat cornea (HP:0007720)1.95776470
112Adducted thumb (HP:0001181)1.95737072
113Abnormal eating behavior (HP:0100738)1.95141001
114Epileptic encephalopathy (HP:0200134)1.94199832
115Premature rupture of membranes (HP:0001788)1.93409674
116Disproportionate tall stature (HP:0001519)1.93333400
117Truncus arteriosus (HP:0001660)1.92759099
118Abnormality of the pons (HP:0007361)1.92120475
119Impaired proprioception (HP:0010831)1.91848989
120Rapidly progressive (HP:0003678)1.89521080
121Bradycardia (HP:0001662)1.87900058
122Bladder diverticulum (HP:0000015)1.87862532
123Mask-like facies (HP:0000298)1.87390678
124Trismus (HP:0000211)1.86707422
125Abnormality of calcium-phosphate metabolism (HP:0100530)1.86263647
126Turricephaly (HP:0000262)1.85470709
127Reticulocytopenia (HP:0001896)1.85128171
128Abnormality of the umbilical cord (HP:0010881)1.84020207
129Coronal craniosynostosis (HP:0004440)1.82974053
130Abnormality of the corticospinal tract (HP:0002492)1.82846505
131Autoamputation (HP:0001218)1.82646274
132Fragile skin (HP:0001030)1.82418576
133Thyroid carcinoma (HP:0002890)1.81537558
134Deviation of the hallux (HP:0010051)1.81394455
135Hyperparathyroidism (HP:0000843)1.80344695
136Impaired vibration sensation in the lower limbs (HP:0002166)1.79851948
137Bowing of the arm (HP:0006488)1.79380398
138Bowed forearm bones (HP:0003956)1.79380398
139Sclerocornea (HP:0000647)1.79083861
140Patellar dislocation (HP:0002999)1.78987439
141Renal dysplasia (HP:0000110)1.78947394
142Lower limb asymmetry (HP:0100559)1.78148494
143Abnormal ventriculo-arterial connection (HP:0011563)1.78045801
144Transposition of the great arteries (HP:0001669)1.78045801
145Abnormal connection of the cardiac segments (HP:0011545)1.78045801
146Abnormality of the distal phalanges of the toes (HP:0010182)1.78044217
147Esophageal atresia (HP:0002032)1.77797910
148Combined immunodeficiency (HP:0005387)1.77472092
149Ventricular fibrillation (HP:0001663)1.77331043
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77027330
151Scanning speech (HP:0002168)1.76893001
152Partial duplication of thumb phalanx (HP:0009944)1.75746990
153Orthostatic hypotension (HP:0001278)1.75255356
154Generalized hypotonia (HP:0001290)1.75221398
155Recurrent bronchitis (HP:0002837)1.75191319
156Sacral dimple (HP:0000960)1.74898242
157Delusions (HP:0000746)1.74325596
158Stomatitis (HP:0010280)1.74299041
159Achilles tendon contracture (HP:0001771)1.74187030
160Posterior embryotoxon (HP:0000627)1.74031429
161Generalized tonic-clonic seizures (HP:0002069)1.73709835
162Decreased muscle mass (HP:0003199)1.73590213
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73170894
164Absent epiphyses (HP:0010577)1.73170894
165Nasolacrimal duct obstruction (HP:0000579)1.73073187
166Iris hypopigmentation (HP:0007730)1.72995542
167Cerebellar dysplasia (HP:0007033)1.72899529
168Nasal polyposis (HP:0100582)1.72084989
169Abnormality of T cells (HP:0002843)1.71924884
170Ankle contracture (HP:0006466)1.71323388
171Hallux valgus (HP:0001822)1.70981262
172Increased nuchal translucency (HP:0010880)1.70716462
173Rib fusion (HP:0000902)1.68814164
174Severe muscular hypotonia (HP:0006829)1.65473080
175Self-mutilation (HP:0000742)1.65417505
176Abnormality of subcutaneous fat tissue (HP:0001001)1.63765584
177Morphological abnormality of the middle ear (HP:0008609)1.63318089
178Myopathic facies (HP:0002058)1.63174357
179Abnormality of the parathyroid morphology (HP:0011766)1.62045849
180Renovascular hypertension (HP:0100817)1.62037039
181Atresia of the external auditory canal (HP:0000413)1.61790528
182High anterior hairline (HP:0009890)1.61656289
183Hypoplastic left heart (HP:0004383)1.61323326
184Premature skin wrinkling (HP:0100678)1.61046963
185Intestinal fistula (HP:0100819)1.60129096
186Abnormality of the line of Schwalbe (HP:0008048)1.58433274
187Abnormality of the distal phalanx of the thumb (HP:0009617)1.58175805
188Elbow flexion contracture (HP:0002987)1.57523804
189Optic nerve coloboma (HP:0000588)1.56754275
190Rectal prolapse (HP:0002035)1.55973963
191Morphological abnormality of the inner ear (HP:0011390)1.55688560
192Absent radius (HP:0003974)1.54480872
193Obstructive sleep apnea (HP:0002870)1.53719061
194Bronchomalacia (HP:0002780)1.52311120
195Genu recurvatum (HP:0002816)1.52044817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.03265119
2MAP3K123.93822487
3SMG13.55297926
4NTRK13.50207961
5VRK23.43186039
6NTRK33.39972519
7KSR23.30252808
8IRAK33.16878312
9MAP3K93.09867560
10SIK13.08175625
11ICK2.88398786
12LIMK12.81184211
13INSRR2.64791048
14MINK12.62771616
15GRK52.47138010
16LMTK22.45741391
17CDK122.37967135
18TXK2.34885775
19RIPK42.29201990
20MAP3K22.21342532
21TESK22.15039476
22BUB12.13309889
23ARAF2.12891209
24EPHA22.10541480
25ZAP701.99340149
26MAP4K11.96320699
27RET1.89335875
28CDK81.69086332
29MATK1.64730889
30PAK61.50781756
31DAPK21.50502905
32NEK21.49611967
33CHEK21.48498112
34ILK1.46166303
35EPHB21.38898997
36MAP3K11.35302039
37BRSK11.34569442
38DAPK11.30389322
39LATS21.30280998
40SIK31.28854935
41CDK71.28697476
42ADRBK21.28021618
43MAPKAPK31.27165294
44PHKG11.25344979
45PHKG21.25344979
46MARK31.24391996
47MST1R1.22804627
48IRAK21.20226753
49MAP3K101.19913694
50SIK21.19825166
51CAMK1D1.18466727
52TAF11.18300938
53TESK11.17593084
54CDC71.16430444
55MET1.15244810
56UHMK11.13154297
57TNK21.12874346
58SCYL21.12527884
59CAMK1G1.10763071
60PRKD21.09101641
61BRAF1.08881726
62MTOR1.08683190
63MAP3K131.07103907
64CAMKK21.06498412
65TAOK11.03014672
66MAP2K71.02693000
67CDK51.00056356
68MAP2K40.99716928
69WNK40.99674696
70NME10.99459245
71ITK0.98969523
72PAK40.97050214
73BCKDK0.96657437
74RAF10.96141159
75EPHA30.94047856
76NLK0.93457007
77AURKA0.93044766
78PNCK0.93033770
79RPS6KA20.89635923
80TNIK0.89581623
81ERN10.89053617
82MAP2K60.88888749
83TYRO30.88661536
84CAMKK10.87423859
85PIM20.87257027
86PRKCI0.86448668
87LCK0.84815303
88MAP3K40.82132099
89GRK60.81652918
90MAPK130.81162190
91STK160.80850892
92JAK30.80677238
93MAP3K110.79890976
94DYRK30.79661252
95CDK140.79371195
96PTK60.79122009
97AKT20.78357926
98FGFR40.76602066
99MARK20.76188975
100DYRK20.75484028
101FGFR30.75239217
102ADRBK10.73664785
103PRKCH0.73281421
104SYK0.72163664
105FES0.70408328
106RPS6KA60.69632723
107MAP2K10.69275083
108LRRK20.67671910
109PDGFRA0.67023590
110ATR0.64090680
111CHEK10.62655014
112WEE10.61957394
113HIPK20.61632296
114STK380.60745548
115RPS6KC10.58136988
116RPS6KL10.58136988
117PKN20.57943160
118RPS6KB20.57933745
119JAK10.57678125
120CDK180.57550043
121TAOK20.57478741
122CSNK1A1L0.56924953
123PRKG20.56129177
124KDR0.55528747
125CDK190.55250792
126BLK0.54061718
127CDK150.53567987
128CSNK1E0.51750646
129CSNK1G10.51724806
130CSNK1G20.51325012
131CDK11A0.50233609
132NTRK20.50215053
133FYN0.49404696
134PDK10.48850330
135CDK90.48779850
136MAP3K80.47953394
137CDK10.47416070
138CDK20.47083607
139MARK10.46720660
140PRKD30.46051946
141PLK10.45698979
142EEF2K0.45661620
143CDK40.44999404
144DAPK30.43792945
145ROCK20.42929076
146FLT30.42136066
147ABL20.41497702
148PRKCG0.41230624
149DMPK0.40542517
150TLK10.39323534
151TTK0.38894914
152PTK20.38538510
153PAK20.38461262
154CDC42BPA0.36746765
155AURKB0.36400771
156KSR10.35925778
157FER0.35777893
158NME20.34375771
159MAP3K70.33698400
160JAK20.33586482
161SRC0.33367819
162CSNK1G30.31620063
163MAP2K20.30409895
164MAPKAPK50.30241752
165CAMK10.29394310
166TEC0.28506500
167HCK0.26519605

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.80194119
2Ribosome_Homo sapiens_hsa030102.95600935
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.75002786
4Synaptic vesicle cycle_Homo sapiens_hsa047212.68174361
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50819062
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.37813713
7One carbon pool by folate_Homo sapiens_hsa006702.23736094
8DNA replication_Homo sapiens_hsa030302.15061225
9Basal cell carcinoma_Homo sapiens_hsa052172.09209520
10Olfactory transduction_Homo sapiens_hsa047401.96451932
11Primary immunodeficiency_Homo sapiens_hsa053401.93700184
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93023861
13RNA polymerase_Homo sapiens_hsa030201.92702044
14Thyroid cancer_Homo sapiens_hsa052161.89425685
15Long-term potentiation_Homo sapiens_hsa047201.80158493
16T cell receptor signaling pathway_Homo sapiens_hsa046601.77942700
17Base excision repair_Homo sapiens_hsa034101.72089445
18Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.71987564
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70729680
20Pyrimidine metabolism_Homo sapiens_hsa002401.69912554
21Spliceosome_Homo sapiens_hsa030401.69878458
22Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.64868739
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63754652
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63057479
25Dopaminergic synapse_Homo sapiens_hsa047281.60156158
26Insulin secretion_Homo sapiens_hsa049111.59337449
27Bladder cancer_Homo sapiens_hsa052191.54924488
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54253499
29Hedgehog signaling pathway_Homo sapiens_hsa043401.53956514
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.51451792
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49133644
32Cholinergic synapse_Homo sapiens_hsa047251.48525900
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.44649497
34Oxidative phosphorylation_Homo sapiens_hsa001901.44048648
35VEGF signaling pathway_Homo sapiens_hsa043701.43416563
36Circadian entrainment_Homo sapiens_hsa047131.41724132
37Homologous recombination_Homo sapiens_hsa034401.41238372
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41067621
39Taste transduction_Homo sapiens_hsa047421.38992900
40Hippo signaling pathway_Homo sapiens_hsa043901.37360333
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33893648
42Vitamin B6 metabolism_Homo sapiens_hsa007501.33096097
43RNA transport_Homo sapiens_hsa030131.32867659
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32852494
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32833526
46Selenocompound metabolism_Homo sapiens_hsa004501.32670654
47Salivary secretion_Homo sapiens_hsa049701.32319250
48Biosynthesis of amino acids_Homo sapiens_hsa012301.31855878
49Glutamatergic synapse_Homo sapiens_hsa047241.31128572
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30905534
51Notch signaling pathway_Homo sapiens_hsa043301.30631188
52N-Glycan biosynthesis_Homo sapiens_hsa005101.27023538
53Cell cycle_Homo sapiens_hsa041101.26504695
54Morphine addiction_Homo sapiens_hsa050321.26456075
55GnRH signaling pathway_Homo sapiens_hsa049121.24151812
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23461348
57Nicotine addiction_Homo sapiens_hsa050331.23103416
58Nucleotide excision repair_Homo sapiens_hsa034201.21856727
59Lysine degradation_Homo sapiens_hsa003101.20884959
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20307804
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18290233
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17245510
63Gastric acid secretion_Homo sapiens_hsa049711.15237513
64Huntingtons disease_Homo sapiens_hsa050161.13740032
65Arginine and proline metabolism_Homo sapiens_hsa003301.13150727
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11985222
67Maturity onset diabetes of the young_Homo sapiens_hsa049501.11525560
68Glioma_Homo sapiens_hsa052141.10232875
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09568831
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.06990888
71Colorectal cancer_Homo sapiens_hsa052101.06377580
72Long-term depression_Homo sapiens_hsa047301.04565115
73Amphetamine addiction_Homo sapiens_hsa050311.03735990
74Gap junction_Homo sapiens_hsa045401.00810983
75GABAergic synapse_Homo sapiens_hsa047271.00715500
76Fanconi anemia pathway_Homo sapiens_hsa034601.00042073
77Oxytocin signaling pathway_Homo sapiens_hsa049210.99857575
78Endometrial cancer_Homo sapiens_hsa052130.98800319
79Endocytosis_Homo sapiens_hsa041440.97782349
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.96904938
81Basal transcription factors_Homo sapiens_hsa030220.96384232
82Shigellosis_Homo sapiens_hsa051310.94920291
83Calcium signaling pathway_Homo sapiens_hsa040200.94708662
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.93309134
85Wnt signaling pathway_Homo sapiens_hsa043100.93208026
86Serotonergic synapse_Homo sapiens_hsa047260.93046827
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93031258
88Estrogen signaling pathway_Homo sapiens_hsa049150.92320429
89Choline metabolism in cancer_Homo sapiens_hsa052310.91893805
90Salmonella infection_Homo sapiens_hsa051320.91605829
91mRNA surveillance pathway_Homo sapiens_hsa030150.91510754
92Oocyte meiosis_Homo sapiens_hsa041140.91159411
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90488767
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89833332
95Viral myocarditis_Homo sapiens_hsa054160.89427540
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88947311
97Collecting duct acid secretion_Homo sapiens_hsa049660.86467879
98Dorso-ventral axis formation_Homo sapiens_hsa043200.85283167
99AMPK signaling pathway_Homo sapiens_hsa041520.84569148
100Renin secretion_Homo sapiens_hsa049240.83601690
101Melanoma_Homo sapiens_hsa052180.83371045
102Non-small cell lung cancer_Homo sapiens_hsa052230.83307361
103Cardiac muscle contraction_Homo sapiens_hsa042600.83302994
104Purine metabolism_Homo sapiens_hsa002300.82742486
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81662708
106Prolactin signaling pathway_Homo sapiens_hsa049170.81327394
107Melanogenesis_Homo sapiens_hsa049160.80927840
108Rap1 signaling pathway_Homo sapiens_hsa040150.80390380
109mTOR signaling pathway_Homo sapiens_hsa041500.79748591
110Insulin signaling pathway_Homo sapiens_hsa049100.79714772
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78475117
112Acute myeloid leukemia_Homo sapiens_hsa052210.78123750
113ErbB signaling pathway_Homo sapiens_hsa040120.77916769
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76327829
115Platelet activation_Homo sapiens_hsa046110.76219540
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76063580
117Folate biosynthesis_Homo sapiens_hsa007900.75517141
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.74624188
119Chemokine signaling pathway_Homo sapiens_hsa040620.73902204
120Mismatch repair_Homo sapiens_hsa034300.73739881
121Hematopoietic cell lineage_Homo sapiens_hsa046400.73262555
122Pancreatic cancer_Homo sapiens_hsa052120.72367325
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72220792
124MAPK signaling pathway_Homo sapiens_hsa040100.71365503
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71356835
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71074866
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69764193
128Chronic myeloid leukemia_Homo sapiens_hsa052200.69465176
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69234447
130Vibrio cholerae infection_Homo sapiens_hsa051100.69038547
131ECM-receptor interaction_Homo sapiens_hsa045120.68569843
132Graft-versus-host disease_Homo sapiens_hsa053320.68199229
133Type II diabetes mellitus_Homo sapiens_hsa049300.67926003
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.66974457
135B cell receptor signaling pathway_Homo sapiens_hsa046620.66303905
136Axon guidance_Homo sapiens_hsa043600.66155757
137Fructose and mannose metabolism_Homo sapiens_hsa000510.65104678
138cAMP signaling pathway_Homo sapiens_hsa040240.65096659
139Galactose metabolism_Homo sapiens_hsa000520.64800826
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64064919
141Pyruvate metabolism_Homo sapiens_hsa006200.62888558
142p53 signaling pathway_Homo sapiens_hsa041150.62551560
143Pentose phosphate pathway_Homo sapiens_hsa000300.62294112
144Pancreatic secretion_Homo sapiens_hsa049720.62085466
145Regulation of autophagy_Homo sapiens_hsa041400.61329033
146Parkinsons disease_Homo sapiens_hsa050120.60928234
147Antigen processing and presentation_Homo sapiens_hsa046120.60221071
148Thyroid hormone synthesis_Homo sapiens_hsa049180.60153542
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57823544
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56635282
151MicroRNAs in cancer_Homo sapiens_hsa052060.56579462
152Glucagon signaling pathway_Homo sapiens_hsa049220.56218149
153Ras signaling pathway_Homo sapiens_hsa040140.55049918
154Metabolic pathways_Homo sapiens_hsa011000.55015432
155AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53641913
156Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53324454
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53031217
158Cocaine addiction_Homo sapiens_hsa050300.52651412
159Steroid biosynthesis_Homo sapiens_hsa001000.51544129
160Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51399390
161Alzheimers disease_Homo sapiens_hsa050100.50561016
162Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46927027
163Renin-angiotensin system_Homo sapiens_hsa046140.46109200
164Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44352865
165RNA degradation_Homo sapiens_hsa030180.43699658
166Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43471752
167Small cell lung cancer_Homo sapiens_hsa052220.40983164
168Carbon metabolism_Homo sapiens_hsa012000.40112080
169Fatty acid biosynthesis_Homo sapiens_hsa000610.39660822
170Prostate cancer_Homo sapiens_hsa052150.38749767
171Prion diseases_Homo sapiens_hsa050200.38300167
172Pathways in cancer_Homo sapiens_hsa052000.37673027
173Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36810355
174Arginine biosynthesis_Homo sapiens_hsa002200.36796368
175Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34102072

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