FAM192A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.24002903
2formation of translation preinitiation complex (GO:0001731)4.43555463
3proteasome assembly (GO:0043248)4.36221228
4DNA deamination (GO:0045006)4.32416940
5mitotic metaphase plate congression (GO:0007080)4.04486818
6nucleobase catabolic process (GO:0046113)4.03385669
7DNA strand elongation involved in DNA replication (GO:0006271)4.02373415
8ribosomal small subunit assembly (GO:0000028)3.99017998
9maturation of SSU-rRNA (GO:0030490)3.93903401
10purine nucleobase biosynthetic process (GO:0009113)3.90066246
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84140261
12anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.81093872
13DNA strand elongation (GO:0022616)3.80582042
14ribosome biogenesis (GO:0042254)3.78499916
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.73795241
16nucleobase biosynthetic process (GO:0046112)3.73632541
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72059243
18DNA replication initiation (GO:0006270)3.65566640
19telomere maintenance via semi-conservative replication (GO:0032201)3.65016630
20protein deneddylation (GO:0000338)3.60541159
21negative regulation of ligase activity (GO:0051352)3.49650451
22negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49650451
23synaptic vesicle maturation (GO:0016188)3.49381807
24mitotic nuclear envelope disassembly (GO:0007077)3.47488141
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46449073
26protein localization to kinetochore (GO:0034501)3.43642126
277-methylguanosine mRNA capping (GO:0006370)3.42125093
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.38154004
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.38154004
30DNA replication checkpoint (GO:0000076)3.37584756
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.35641138
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.35641138
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.35641138
34telomere maintenance via recombination (GO:0000722)3.34842659
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34571651
36ribonucleoprotein complex biogenesis (GO:0022613)3.34525458
37negative regulation of DNA recombination (GO:0045910)3.33689673
38metaphase plate congression (GO:0051310)3.33515456
39RNA capping (GO:0036260)3.33492015
407-methylguanosine RNA capping (GO:0009452)3.33492015
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.31025687
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31025687
43cullin deneddylation (GO:0010388)3.30818003
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.29257365
45establishment of chromosome localization (GO:0051303)3.29122427
46regulation of spindle organization (GO:0090224)3.29067087
47DNA unwinding involved in DNA replication (GO:0006268)3.29014059
48viral mRNA export from host cell nucleus (GO:0046784)3.28810745
49spliceosomal snRNP assembly (GO:0000387)3.26689356
50establishment of integrated proviral latency (GO:0075713)3.26057425
51regulation of cellular amino acid metabolic process (GO:0006521)3.25886275
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23491280
53nuclear envelope disassembly (GO:0051081)3.21183893
54membrane disassembly (GO:0030397)3.21183893
55CENP-A containing nucleosome assembly (GO:0034080)3.20466657
56regulation of synaptic vesicle exocytosis (GO:2000300)3.19906168
57establishment of mitochondrion localization (GO:0051654)3.18843586
58ribosome assembly (GO:0042255)3.18398763
59positive regulation of ligase activity (GO:0051351)3.16571944
60protein localization to chromosome, centromeric region (GO:0071459)3.15350532
61DNA replication-independent nucleosome organization (GO:0034724)3.14114584
62DNA replication-independent nucleosome assembly (GO:0006336)3.14114584
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.13728668
64termination of RNA polymerase III transcription (GO:0006386)3.13728668
65mitotic recombination (GO:0006312)3.12317291
66attachment of spindle microtubules to kinetochore (GO:0008608)3.10984789
67transcription-coupled nucleotide-excision repair (GO:0006283)3.10489170
68kinetochore organization (GO:0051383)3.09766675
69regulation of cilium movement (GO:0003352)3.08951777
70IMP biosynthetic process (GO:0006188)3.08724253
71ribonucleoprotein complex disassembly (GO:0032988)3.08714062
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.08387911
73chromatin remodeling at centromere (GO:0031055)3.07190271
74mRNA splice site selection (GO:0006376)3.05945713
75kinetochore assembly (GO:0051382)3.05302523
76spliceosomal complex assembly (GO:0000245)3.04421692
77DNA replication-dependent nucleosome assembly (GO:0006335)3.03647213
78DNA replication-dependent nucleosome organization (GO:0034723)3.03647213
79folic acid-containing compound biosynthetic process (GO:0009396)3.01756858
80cell cycle G1/S phase transition (GO:0044843)3.00157758
81G1/S transition of mitotic cell cycle (GO:0000082)3.00157758
82microtubule depolymerization (GO:0007019)2.99265944
83regulation of ubiquitin-protein transferase activity (GO:0051438)2.98841445
84rRNA processing (GO:0006364)2.98199438
85organelle disassembly (GO:1903008)2.97429803
86ribosomal small subunit biogenesis (GO:0042274)2.96952627
87histone H2A acetylation (GO:0043968)2.96240388
88maturation of 5.8S rRNA (GO:0000460)2.96203402
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.95975689
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95094932
91DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.94929470
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93193688
93purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.92038320
94translational initiation (GO:0006413)2.91442217
95pseudouridine synthesis (GO:0001522)2.90736582
96rRNA metabolic process (GO:0016072)2.87394522
97protein neddylation (GO:0045116)2.87249921
98resolution of meiotic recombination intermediates (GO:0000712)2.86412053
99positive regulation of cell cycle arrest (GO:0071158)2.86035113
100regulation of ligase activity (GO:0051340)2.85244062
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84229991
102telomere maintenance via telomere lengthening (GO:0010833)2.83840770
103transcription elongation from RNA polymerase I promoter (GO:0006362)2.82540721
104mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82417741
105IMP metabolic process (GO:0046040)2.82133402
106ribosomal large subunit biogenesis (GO:0042273)2.80472801
107deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.80021980
108cellular component biogenesis (GO:0044085)2.75734104
109transcription from RNA polymerase I promoter (GO:0006360)2.75146468
110transcription elongation from RNA polymerase II promoter (GO:0006368)2.75115510
111DNA damage response, detection of DNA damage (GO:0042769)2.74654419
112viral transcription (GO:0019083)2.74217694
113spindle checkpoint (GO:0031577)2.73152638
114energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72130376
115ATP synthesis coupled proton transport (GO:0015986)2.72130376
116postreplication repair (GO:0006301)2.71944799
117regulation of double-strand break repair via homologous recombination (GO:0010569)2.70958506
118mitotic spindle assembly checkpoint (GO:0007094)2.69808116
119RNA splicing, via transesterification reactions (GO:0000375)2.69742896
120sequestering of actin monomers (GO:0042989)2.68611808
121negative regulation of telomere maintenance (GO:0032205)2.68369981
122positive regulation of granulocyte differentiation (GO:0030854)2.67794315
123DNA ligation (GO:0006266)2.67181916
124DNA double-strand break processing (GO:0000729)2.64243265
125postsynaptic membrane organization (GO:0001941)2.61227178
126centriole replication (GO:0007099)2.58372648
127regulation of synaptic vesicle transport (GO:1902803)2.53019745
128regulation of microtubule-based movement (GO:0060632)2.52563102
129negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52196145
130microtubule polymerization or depolymerization (GO:0031109)2.50086965
131negative regulation of DNA-dependent DNA replication (GO:2000104)2.48728395
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48515828
133synaptic vesicle exocytosis (GO:0016079)2.48222762
134positive regulation of response to oxidative stress (GO:1902884)2.42714791
135positive regulation of cellular response to oxidative stress (GO:1900409)2.42714791
136deoxyribose phosphate biosynthetic process (GO:0046385)2.41694021
1372-deoxyribonucleotide biosynthetic process (GO:0009265)2.41694021
138neuron cell-cell adhesion (GO:0007158)2.40006695
139histone H4-K16 acetylation (GO:0043984)2.35443295
140replication fork processing (GO:0031297)2.35125526
141negative regulation of microtubule polymerization (GO:0031115)2.34188195
142purine deoxyribonucleotide metabolic process (GO:0009151)2.34185264
143pyrimidine dimer repair (GO:0006290)2.33902404
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.33041456
145mRNA splicing, via spliceosome (GO:0000398)2.32088892
146RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.32088892
147positive regulation of gamma-delta T cell activation (GO:0046645)2.29409211
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.29367118
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.29367118
150cell migration in hindbrain (GO:0021535)2.29286242
151establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.26371800
152mitochondrion transport along microtubule (GO:0047497)2.26371800
153positive regulation of dendritic spine morphogenesis (GO:0061003)2.25819406
154negative regulation of histone acetylation (GO:0035067)2.25614771
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.25478549
156mitotic sister chromatid cohesion (GO:0007064)2.24660730
157negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24024053
158negative regulation of cell killing (GO:0031342)2.24024053
159protein polyglutamylation (GO:0018095)2.23144553
160deoxyribonucleotide biosynthetic process (GO:0009263)2.23108777
161regulation of B cell receptor signaling pathway (GO:0050855)2.21418431
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.20787261
163maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.20146883
164histone H4-K5 acetylation (GO:0043981)2.19594518
165histone H4-K8 acetylation (GO:0043982)2.19594518
166DNA catabolic process, exonucleolytic (GO:0000738)2.18513466
167activated T cell proliferation (GO:0050798)2.17193790
168regulation of helicase activity (GO:0051095)2.16080863
169glycosphingolipid biosynthetic process (GO:0006688)2.15392001
170regulation of mRNA splicing, via spliceosome (GO:0048024)2.14907175
171Arp2/3 complex-mediated actin nucleation (GO:0034314)2.14634975
172regulation of synapse structural plasticity (GO:0051823)2.14514708
173respiratory electron transport chain (GO:0022904)2.12685156
174negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.11618981
175negative regulation of RNA splicing (GO:0033119)2.11305190
176synapsis (GO:0007129)2.11021822
177positive regulation of RNA splicing (GO:0033120)2.10490419
178nucleosome disassembly (GO:0006337)2.10345444
179protein-DNA complex disassembly (GO:0032986)2.10345444
180rRNA catabolic process (GO:0016075)2.09846432
181positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.09032953
182oxidative phosphorylation (GO:0006119)2.08235096
183electron transport chain (GO:0022900)2.07884249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.13176552
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.13440189
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75438613
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.62059865
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.60296310
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58241000
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25163115
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09411106
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07361913
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02396204
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02098445
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.97795120
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.86775734
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78996385
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77613796
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73744288
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69101341
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64285104
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56135874
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51545589
21VDR_23849224_ChIP-Seq_CD4+_Human2.50027506
22XRN2_22483619_ChIP-Seq_HELA_Human2.38274556
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29925267
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22817113
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19521140
26FOXP3_21729870_ChIP-Seq_TREG_Human2.15243719
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12805159
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12138136
29DCP1A_22483619_ChIP-Seq_HELA_Human2.10874386
30GABP_19822575_ChIP-Seq_HepG2_Human2.10495231
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03262793
32EGR1_19374776_ChIP-ChIP_THP-1_Human2.02511937
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02188813
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98899454
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97159460
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91866811
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86811374
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86307285
39TTF2_22483619_ChIP-Seq_HELA_Human1.86257474
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.84531389
41AR_21909140_ChIP-Seq_LNCAP_Human1.84282538
42ELK1_19687146_ChIP-ChIP_HELA_Human1.84198988
43ZNF274_21170338_ChIP-Seq_K562_Hela1.83893861
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82118367
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.80920787
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80345947
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80036315
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79213702
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78613267
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74513393
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72150142
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.68368959
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63811873
54CIITA_25753668_ChIP-Seq_RAJI_Human1.59296396
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59226794
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56558206
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55472118
58KDM5A_27292631_Chip-Seq_BREAST_Human1.54951552
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53944594
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53205754
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49421183
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48675957
63IGF1R_20145208_ChIP-Seq_DFB_Human1.47639598
64EZH2_22144423_ChIP-Seq_EOC_Human1.46422991
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40967726
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.40727730
67* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37733696
68* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37514416
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34948488
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34865984
71MYC_22102868_ChIP-Seq_BL_Human1.31081310
72* TFEB_21752829_ChIP-Seq_HELA_Human1.29637940
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.27080102
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.27060050
75REST_21632747_ChIP-Seq_MESCs_Mouse1.25373555
76* SPI1_23547873_ChIP-Seq_NB4_Human1.21308195
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17277119
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16141104
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16000719
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15576029
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.12874739
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12861959
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11077238
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.07896798
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06618368
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02294735
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02136382
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01073297
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.01058545
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00270503
91* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00243420
92IRF1_19129219_ChIP-ChIP_H3396_Human1.00234776
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00228222
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99021779
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97518948
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97301872
97MYC_18940864_ChIP-ChIP_HL60_Human0.96696134
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96254798
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95154160
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94256471
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94216958
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93266488
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91223825
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86198687
105E2F1_17053090_ChIP-ChIP_MCF-7_Human0.85917974
106* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83803063
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.83633907
108STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82864736
109GBX2_23144817_ChIP-Seq_PC3_Human0.82632360
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81715463
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81609426
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80337372
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78186943
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78070634
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77899419
116VDR_21846776_ChIP-Seq_THP-1_Human0.77593325
117EWS_26573619_Chip-Seq_HEK293_Human0.75349618
118MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74826290
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74686686
120TP53_22573176_ChIP-Seq_HFKS_Human0.72585060
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72461452
122ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72293301
123MYB_26560356_Chip-Seq_TH2_Human0.72283101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.39332636
2MP0008057_abnormal_DNA_replication4.23259128
3MP0003111_abnormal_nucleus_morphology4.21800863
4MP0004957_abnormal_blastocyst_morpholog4.11553122
5MP0010094_abnormal_chromosome_stability4.08751665
6MP0003077_abnormal_cell_cycle3.90663502
7MP0003880_abnormal_central_pattern3.29325861
8MP0008058_abnormal_DNA_repair3.15890880
9MP0008007_abnormal_cellular_replicative3.00729882
10MP0008877_abnormal_DNA_methylation2.86981240
11MP0002653_abnormal_ependyma_morphology2.86096976
12MP0004859_abnormal_synaptic_plasticity2.80931935
13MP0008932_abnormal_embryonic_tissue2.64124745
14MP0002396_abnormal_hematopoietic_system2.28846780
15MP0003123_paternal_imprinting2.19319937
16MP0005423_abnormal_somatic_nervous2.16294630
17MP0003635_abnormal_synaptic_transmissio2.07978506
18MP0000350_abnormal_cell_proliferation2.06742892
19MP0001730_embryonic_growth_arrest1.95672796
20MP0001986_abnormal_taste_sensitivity1.95615552
21MP0003718_maternal_effect1.94198863
22MP0004270_analgesia1.87575659
23MP0006276_abnormal_autonomic_nervous1.86986865
24MP0001188_hyperpigmentation1.84794391
25MP0002063_abnormal_learning/memory/cond1.75684937
26MP0003186_abnormal_redox_activity1.74430552
27MP0003763_abnormal_thymus_physiology1.74229192
28MP0003122_maternal_imprinting1.67892766
29MP0009745_abnormal_behavioral_response1.67877425
30MP0000313_abnormal_cell_death1.65341633
31MP0002822_catalepsy1.64873910
32MP0003121_genomic_imprinting1.62484098
33MP0004142_abnormal_muscle_tone1.62415632
34MP0001968_abnormal_touch/_nociception1.62315353
35MP0001835_abnormal_antigen_presentation1.59058132
36MP0004808_abnormal_hematopoietic_stem1.57763328
37MP0002064_seizures1.57460340
38MP0003786_premature_aging1.57439165
39MP0009333_abnormal_splenocyte_physiolog1.57403595
40MP0002736_abnormal_nociception_after1.54333052
41MP0000490_abnormal_crypts_of1.54305454
42MP0002398_abnormal_bone_marrow1.52756456
43MP0001984_abnormal_olfaction1.52733326
44MP0001697_abnormal_embryo_size1.50396214
45MP0004811_abnormal_neuron_physiology1.50301499
46MP0004147_increased_porphyrin_level1.50297549
47MP0001486_abnormal_startle_reflex1.49999411
48MP0002102_abnormal_ear_morphology1.46276246
49MP0003656_abnormal_erythrocyte_physiolo1.42215255
50MP0002019_abnormal_tumor_incidence1.42189432
51MP0009785_altered_susceptibility_to1.39578121
52MP0005671_abnormal_response_to1.38807268
53MP0000858_altered_metastatic_potential1.38456301
54MP0000685_abnormal_immune_system1.37941015
55MP0001545_abnormal_hematopoietic_system1.37844039
56MP0005397_hematopoietic_system_phenotyp1.37844039
57MP0008789_abnormal_olfactory_epithelium1.37561531
58MP0009046_muscle_twitch1.37077036
59MP0000778_abnormal_nervous_system1.35334159
60MP0002080_prenatal_lethality1.34682273
61MP0003221_abnormal_cardiomyocyte_apopto1.33750853
62MP0006036_abnormal_mitochondrial_physio1.32559366
63MP0002067_abnormal_sensory_capabilities1.32275526
64MP0000689_abnormal_spleen_morphology1.31003920
65MP0002272_abnormal_nervous_system1.30195962
66MP0006035_abnormal_mitochondrial_morpho1.30136785
67MP0000703_abnormal_thymus_morphology1.29379505
68MP0006292_abnormal_olfactory_placode1.28590417
69MP0003646_muscle_fatigue1.28558298
70MP0001672_abnormal_embryogenesis/_devel1.27803634
71MP0005380_embryogenesis_phenotype1.27803634
72MP0002572_abnormal_emotion/affect_behav1.27602577
73MP0002210_abnormal_sex_determination1.26017840
74MP0002722_abnormal_immune_system1.25234204
75MP0010352_gastrointestinal_tract_polyps1.23579707
76MP0002734_abnormal_mechanical_nocicepti1.22170396
77MP0002429_abnormal_blood_cell1.22104299
78MP0001529_abnormal_vocalization1.21691746
79MP0000716_abnormal_immune_system1.19601573
80MP0001905_abnormal_dopamine_level1.18781791
81MP0008260_abnormal_autophagy1.18695867
82MP0002085_abnormal_embryonic_tissue1.18596398
83MP0002452_abnormal_antigen_presenting1.16607596
84MP0001819_abnormal_immune_cell1.15776248
85MP0003315_abnormal_perineum_morphology1.15683960
86MP0002420_abnormal_adaptive_immunity1.15572557
87MP0002557_abnormal_social/conspecific_i1.15218540
88MP0003984_embryonic_growth_retardation1.14557646
89MP0002733_abnormal_thermal_nociception1.13682591
90MP0008569_lethality_at_weaning1.13668583
91MP0002277_abnormal_respiratory_mucosa1.12881834
92MP0001800_abnormal_humoral_immune1.11272777
93MP0001119_abnormal_female_reproductive1.10850470
94MP0001970_abnormal_pain_threshold1.10007380
95MP0008995_early_reproductive_senescence1.09994427
96MP0002088_abnormal_embryonic_growth/wei1.09758783
97MP0002148_abnormal_hypersensitivity_rea1.08438636
98MP0001929_abnormal_gametogenesis1.08222304
99MP0002723_abnormal_immune_serum1.05088508
100MP0003303_peritoneal_inflammation1.03690489
101MP0002084_abnormal_developmental_patter1.03575736
102MP0004742_abnormal_vestibular_system1.03390131
103MP0002882_abnormal_neuron_morphology1.03124566
104MP0002751_abnormal_autonomic_nervous1.02746552
105MP0010307_abnormal_tumor_latency1.01292008
106MP0005075_abnormal_melanosome_morpholog1.00319429
107MP0006082_CNS_inflammation1.00189023
108MP0001348_abnormal_lacrimal_gland0.99347478
109MP0005000_abnormal_immune_tolerance0.99021824
110MP0003724_increased_susceptibility_to0.97721360
111MP0005384_cellular_phenotype0.97551530
112MP0002095_abnormal_skin_pigmentation0.97541683
113MP0001145_abnormal_male_reproductive0.96090307
114MP0003787_abnormal_imprinting0.94848434
115MP0005621_abnormal_cell_physiology0.94606858
116MP0000653_abnormal_sex_gland0.94518407
117MP0000372_irregular_coat_pigmentation0.94460634
118MP0003690_abnormal_glial_cell0.94155341
119MP0002152_abnormal_brain_morphology0.94147166
120MP0003938_abnormal_ear_development0.93629376
121MP0002735_abnormal_chemical_nociception0.93420866
122MP0009278_abnormal_bone_marrow0.92972187
123MP0005025_abnormal_response_to0.92923339
124MP0005645_abnormal_hypothalamus_physiol0.92855786
125MP0004197_abnormal_fetal_growth/weight/0.91364116
126MP0002419_abnormal_innate_immunity0.90494372
127MP0005386_behavior/neurological_phenoty0.90070281
128MP0004924_abnormal_behavior0.90070281
129MP0001293_anophthalmia0.89880666
130MP0003172_abnormal_lysosome_physiology0.89755420
131MP0002066_abnormal_motor_capabilities/c0.89342512
132MP0003806_abnormal_nucleotide_metabolis0.87986689
133MP0003436_decreased_susceptibility_to0.87419802
134MP0002132_abnormal_respiratory_system0.85945880
135MP0000955_abnormal_spinal_cord0.85396596
136MP0002086_abnormal_extraembryonic_tissu0.85273334
137MP0001485_abnormal_pinna_reflex0.83946057
138MP0000358_abnormal_cell_content/0.83304213
139MP0002638_abnormal_pupillary_reflex0.82806114
140MP0003698_abnormal_male_reproductive0.81734443
141MP0005464_abnormal_platelet_physiology0.80481064
142MP0000631_abnormal_neuroendocrine_gland0.79472951
143MP0001790_abnormal_immune_system0.77637386
144MP0005387_immune_system_phenotype0.77637386
145MP0004885_abnormal_endolymph0.76793382
146MP0002405_respiratory_system_inflammati0.73887768
147MP0005499_abnormal_olfactory_system0.72805166
148MP0005394_taste/olfaction_phenotype0.72805166
149MP0005310_abnormal_salivary_gland0.70901600
150MP0002160_abnormal_reproductive_system0.68015130
151MP0005076_abnormal_cell_differentiation0.67943252
152MP0000343_altered_response_to0.67812227
153MP0003950_abnormal_plasma_membrane0.65245920
154MP0003890_abnormal_embryonic-extraembry0.62941030
155MP0001915_intracranial_hemorrhage0.62841419
156MP0009672_abnormal_birth_weight0.62791389
157MP0006054_spinal_hemorrhage0.62786266
158MP0010030_abnormal_orbit_morphology0.61086610
159MP0000465_gastrointestinal_hemorrhage0.59728792
160MP0003567_abnormal_fetal_cardiomyocyte0.56389485

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)4.88405197
2Abnormality of the anterior horn cell (HP:0006802)4.88405197
3Birth length less than 3rd percentile (HP:0003561)4.66145485
4Cerebral hypomyelination (HP:0006808)4.54064213
5Carpal bone hypoplasia (HP:0001498)4.09463224
6Abnormality of glycolysis (HP:0004366)3.79504261
7Increased serum pyruvate (HP:0003542)3.79504261
8Patellar aplasia (HP:0006443)3.61253417
9Irregular epiphyses (HP:0010582)3.40257231
10Breast hypoplasia (HP:0003187)3.39278317
11Aplasia/Hypoplasia of the patella (HP:0006498)3.32443685
12Papilledema (HP:0001085)3.11560102
13Agnosia (HP:0010524)2.92271366
14Aplastic anemia (HP:0001915)2.90086136
15Myokymia (HP:0002411)2.85145703
16Colon cancer (HP:0003003)2.77536215
17Oral leukoplakia (HP:0002745)2.77297303
18Hypochromic microcytic anemia (HP:0004840)2.64651816
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.64113556
20Hypoplasia of the capital femoral epiphysis (HP:0003090)2.64038675
21Atrophy/Degeneration involving motor neurons (HP:0007373)2.63862534
22Abnormality of alanine metabolism (HP:0010916)2.61952959
23Hyperalaninemia (HP:0003348)2.61952959
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61952959
25Reticulocytopenia (HP:0001896)2.59814720
26Abnormality of cells of the erythroid lineage (HP:0012130)2.57606860
27Panhypogammaglobulinemia (HP:0003139)2.57225866
28Microretrognathia (HP:0000308)2.56059129
29CNS hypomyelination (HP:0003429)2.49628823
30Increased hepatocellular lipid droplets (HP:0006565)2.49349073
31Cortical dysplasia (HP:0002539)2.49115589
32Poor head control (HP:0002421)2.48481163
33Rough bone trabeculation (HP:0100670)2.48112426
34Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.44570749
35Absent epiphyses (HP:0010577)2.44570749
36Microvesicular hepatic steatosis (HP:0001414)2.44087280
37Abnormality of the labia minora (HP:0012880)2.44067834
38Methylmalonic acidemia (HP:0002912)2.39747112
39Oligodactyly (hands) (HP:0001180)2.38372199
40Optic nerve coloboma (HP:0000588)2.37955338
41Progressive macrocephaly (HP:0004481)2.36281744
42Medulloblastoma (HP:0002885)2.31018176
43Abnormal number of erythroid precursors (HP:0012131)2.30797905
44Prominent metopic ridge (HP:0005487)2.28837349
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.26492611
46Abnormality of the metopic suture (HP:0005556)2.25453886
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.25350809
48Personality changes (HP:0000751)2.24214398
49Muscle fiber atrophy (HP:0100295)2.23951201
50Prolonged neonatal jaundice (HP:0006579)2.23499262
51Increased intramyocellular lipid droplets (HP:0012240)2.23063967
52Abnormal gallbladder physiology (HP:0012438)2.23023247
53Cholecystitis (HP:0001082)2.23023247
54Recurrent abscess formation (HP:0002722)2.20876946
55IgM deficiency (HP:0002850)2.19160802
56Type 2 muscle fiber atrophy (HP:0003554)2.18633045
57Gait imbalance (HP:0002141)2.18509824
58Flat capital femoral epiphysis (HP:0003370)2.18222074
59Lipid accumulation in hepatocytes (HP:0006561)2.15922047
60Premature ovarian failure (HP:0008209)2.15575087
61Medial flaring of the eyebrow (HP:0010747)2.15384754
62Cleft eyelid (HP:0000625)2.14980743
63Selective tooth agenesis (HP:0001592)2.13989916
64Bone marrow hypocellularity (HP:0005528)2.13897451
65Cellular immunodeficiency (HP:0005374)2.12664903
66Abnormality of the preputium (HP:0100587)2.11964577
67Respiratory difficulties (HP:0002880)2.11007661
68Combined immunodeficiency (HP:0005387)2.10426444
69Severe combined immunodeficiency (HP:0004430)2.10190164
70Acute encephalopathy (HP:0006846)2.10107173
71Hepatic necrosis (HP:0002605)2.09165298
72Hyperglycinemia (HP:0002154)2.09127205
733-Methylglutaconic aciduria (HP:0003535)2.08673924
74Meckel diverticulum (HP:0002245)2.08519254
75Hepatocellular necrosis (HP:0001404)2.07871640
76Agammaglobulinemia (HP:0004432)2.06881903
77Increased CSF lactate (HP:0002490)2.06869219
78Unsteady gait (HP:0002317)2.06834037
79Myelodysplasia (HP:0002863)2.06417436
80Abnormality of the ileum (HP:0001549)2.05901371
81Abnormality of chromosome stability (HP:0003220)2.05673028
82Impulsivity (HP:0100710)2.04057090
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.03945696
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03945696
85Increased serum lactate (HP:0002151)2.03568550
86Amaurosis fugax (HP:0100576)2.03146646
87Nephrogenic diabetes insipidus (HP:0009806)2.03130761
88Pendular nystagmus (HP:0012043)2.02831081
89Lissencephaly (HP:0001339)2.01935760
90Obstructive lung disease (HP:0006536)2.00791259
91Chronic obstructive pulmonary disease (HP:0006510)2.00791259
92Small epiphyses (HP:0010585)2.00319870
93Tongue fasciculations (HP:0001308)1.99648253
94Acute necrotizing encephalopathy (HP:0006965)1.98926164
95Mitochondrial inheritance (HP:0001427)1.98879788
96Thrombocytosis (HP:0001894)1.98799928
97Ankle clonus (HP:0011448)1.98373789
98Amyotrophic lateral sclerosis (HP:0007354)1.97906886
99Neoplasm of the pancreas (HP:0002894)1.97558285
100Mediastinal lymphadenopathy (HP:0100721)1.96720297
101Methylmalonic aciduria (HP:0012120)1.96458127
102Abnormality of DNA repair (HP:0003254)1.96274744
103Glossoptosis (HP:0000162)1.95922745
104Secondary amenorrhea (HP:0000869)1.95876612
105Urinary urgency (HP:0000012)1.94780784
106Sloping forehead (HP:0000340)1.94393311
107Optic disc pallor (HP:0000543)1.94166406
108Lymphoma (HP:0002665)1.92859587
109Chromsome breakage (HP:0040012)1.92451500
110Abnormal mitochondria in muscle tissue (HP:0008316)1.92262958
111Congenital primary aphakia (HP:0007707)1.92128389
112Recurrent bacterial skin infections (HP:0005406)1.92111349
113Abnormal lung lobation (HP:0002101)1.90809179
114Focal motor seizures (HP:0011153)1.90673779
115Poikiloderma (HP:0001029)1.89952629
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.88394103
117Absent thumb (HP:0009777)1.86829876
118Peripheral hypomyelination (HP:0007182)1.86625079
119Spastic gait (HP:0002064)1.84922238
120Leukodystrophy (HP:0002415)1.83061526
121Macrocytic anemia (HP:0001972)1.82492110
122Stenosis of the external auditory canal (HP:0000402)1.82226027
123Type I transferrin isoform profile (HP:0003642)1.81780906
124Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81493401
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81493401
126Abnormal trabecular bone morphology (HP:0100671)1.81252646
127Abnormal respiratory epithelium morphology (HP:0012253)1.80843281
128Abnormal respiratory motile cilium morphology (HP:0005938)1.80843281
129IgG deficiency (HP:0004315)1.78974260
130Adrenal hypoplasia (HP:0000835)1.77825273
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77683099
132Elevated erythrocyte sedimentation rate (HP:0003565)1.77587726
133Basal cell carcinoma (HP:0002671)1.76655860
134Volvulus (HP:0002580)1.76454209
135Entropion (HP:0000621)1.76194355
136Abnormality of the corticospinal tract (HP:0002492)1.75451073
137Aplasia/Hypoplasia involving the musculature (HP:0001460)1.75424566
138Febrile seizures (HP:0002373)1.75359340
139Premature graying of hair (HP:0002216)1.75237865
140Horseshoe kidney (HP:0000085)1.74644120
141Stomatitis (HP:0010280)1.74333417
142Cerebral edema (HP:0002181)1.74026724
143Postnatal microcephaly (HP:0005484)1.73033982
144Abnormality of lateral ventricle (HP:0030047)1.72899793
145Exertional dyspnea (HP:0002875)1.71751558
146Oligodactyly (HP:0012165)1.71433356
147Atresia of the external auditory canal (HP:0000413)1.71358143
148Abnormality of the epiphysis of the femoral head (HP:0010574)1.70897196
149Emotional lability (HP:0000712)1.69304964
150Encephalitis (HP:0002383)1.69280125
151Rhabdomyosarcoma (HP:0002859)1.69043986
152Abnormality of the femoral head (HP:0003368)1.68475552
153Increased muscle lipid content (HP:0009058)1.68428141
154Polyphagia (HP:0002591)1.67365128
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67086531
156Epileptic encephalopathy (HP:0200134)1.66436908
157Abnormal delayed hypersensitivity skin test (HP:0002963)1.66125745
158Multiple enchondromatosis (HP:0005701)1.65583235
159Progressive cerebellar ataxia (HP:0002073)1.65492373
160Excessive salivation (HP:0003781)1.64522366
161Pachygyria (HP:0001302)1.62174590
162Renal Fanconi syndrome (HP:0001994)1.60377279
163Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.60027987
164Muscular hypotonia of the trunk (HP:0008936)1.59248988
165Neuroendocrine neoplasm (HP:0100634)1.58410086
166Drooling (HP:0002307)1.58128719
167Abnormality of the vitamin B12 metabolism (HP:0004341)1.57633805
168Meningitis (HP:0001287)1.57281786
169Poor eye contact (HP:0000817)1.55074700
170Split foot (HP:0001839)1.54880096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.60866858
2BUB14.08305721
3SIK23.63404289
4CDC73.38172903
5WNK33.34010002
6WEE13.03248672
7ACVR1B2.88402365
8RIPK42.80794424
9MARK12.69629317
10NME22.65386314
11CDK192.59799006
12EIF2AK32.52828015
13SRPK12.38124265
14STK162.32806430
15NEK22.11098433
16TESK22.00525119
17VRK21.99847235
18MAPK131.95837007
19MKNK11.91936406
20PLK41.89294747
21MAP4K21.87104958
22MAP2K71.85770112
23MAP3K41.83560579
24TSSK61.82343861
25VRK11.80917885
26PLK31.67617121
27DYRK31.66971858
28PLK11.65646256
29EIF2AK21.61070602
30TTK1.55742010
31BRSK21.52480731
32MKNK21.50239135
33MINK11.49161961
34TNIK1.46403741
35RPS6KB21.41353047
36STK101.41204690
37EPHA41.39293075
38TRIM281.38049632
39TESK11.35433618
40NEK11.31733263
41ATR1.30756932
42STK241.27232423
43CDK71.24587872
44NUAK11.24220293
45AURKB1.19334748
46PIM21.18322755
47MAP3K141.17182244
48UHMK11.16530089
49YES11.16171674
50FES1.15586798
51AURKA1.14844938
52PBK1.12791275
53PASK1.12352732
54CHEK21.12207206
55TAOK31.09409647
56CCNB11.08363251
57DYRK21.07542856
58MAP2K41.05900986
59TGFBR11.05882307
60CDK81.05513869
61MAP3K131.04906129
62MAP3K81.04460166
63BRSK11.04456466
64ALK1.03441280
65CSNK1G21.03181965
66RPS6KA41.03074580
67ERBB31.03059453
68STK41.01819979
69CSNK1G31.01561048
70JAK31.00375005
71IRAK40.99953906
72BRAF0.99422889
73LIMK10.98963871
74NTRK20.97816234
75TNK20.96307790
76KSR10.92887277
77NME10.92830337
78MAP4K10.92752801
79CDK140.91155481
80MAP3K100.88963743
81PAK40.88604352
82TLK10.87265778
83DYRK1A0.85523488
84BCR0.85472569
85CDK180.83344100
86CHEK10.82426984
87CSNK1A1L0.80422556
88STK30.80099897
89MAP3K120.80042013
90CDK11A0.80008086
91CDK150.79091254
92PAK60.77645409
93DYRK1B0.77450007
94CDK50.76583436
95STK38L0.74839692
96FGR0.74059801
97MAP2K30.73927076
98MAPKAPK30.73906408
99SCYL20.72555802
100PNCK0.71150190
101BTK0.68969437
102IRAK20.68377423
103EEF2K0.68196314
104CDK40.67122185
105LRRK20.65700670
106TXK0.65407923
107BMPR20.64538278
108PIM10.64499149
109CDK20.64221580
110DAPK10.63409907
111MAP3K110.62734283
112LYN0.62047293
113PINK10.60700631
114ZAK0.59895281
115SGK4940.59647171
116SGK2230.59647171
117SIK30.59573851
118MAP3K60.59529710
119TAOK20.58906803
120CSNK2A10.58784071
121KIT0.58477265
122PAK10.58325943
123ZAP700.58195254
124MST40.57926594
125ATM0.57531456
126CLK10.56718466
127CSNK1G10.56678538
128MARK20.54900192
129GRK50.53813183
130BLK0.51963927
131MAP3K50.50805238
132KDR0.50551276
133CSNK2A20.50315973
134MATK0.49823580
135CASK0.49480790
136STK110.48752977
137CDK10.48207919
138DAPK20.47551169
139SGK20.47095711
140RPS6KA50.46608615
141FYN0.46488435
142PRKCG0.45732514
143HCK0.45602361
144CDK120.45001789
145NTRK30.44987479
146CAMKK10.44376470
147SGK10.44215187
148PLK20.43568295
149PRKCI0.43397553
150CSNK1E0.43376522
151IRAK30.43137560
152CAMKK20.43136917
153CHUK0.42787951
154PKN10.42751122
155JAK20.41309089
156SYK0.41051288
157IKBKB0.40964609
158ERBB40.40932575
159ITK0.40250692
160ADRBK20.39724147
161NEK90.36202558
162FLT30.34746795
163MELK0.34587851
164ILK0.33178065
165TYK20.31781886
166MAPKAPK20.31728085

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.41468700
2DNA replication_Homo sapiens_hsa030304.08028436
3RNA polymerase_Homo sapiens_hsa030203.59169451
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48023812
5Mismatch repair_Homo sapiens_hsa034303.44883331
6Spliceosome_Homo sapiens_hsa030403.24907974
7RNA transport_Homo sapiens_hsa030133.07702749
8Ribosome_Homo sapiens_hsa030102.99412886
9Nucleotide excision repair_Homo sapiens_hsa034202.73677651
10Base excision repair_Homo sapiens_hsa034102.69779792
11Homologous recombination_Homo sapiens_hsa034402.64504057
12Cell cycle_Homo sapiens_hsa041102.55651993
13Pyrimidine metabolism_Homo sapiens_hsa002402.39557951
14Basal transcription factors_Homo sapiens_hsa030222.25458095
15RNA degradation_Homo sapiens_hsa030181.89884131
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86294704
17Synaptic vesicle cycle_Homo sapiens_hsa047211.78217831
18Nicotine addiction_Homo sapiens_hsa050331.75234441
19One carbon pool by folate_Homo sapiens_hsa006701.74877609
20Fanconi anemia pathway_Homo sapiens_hsa034601.72929597
21Collecting duct acid secretion_Homo sapiens_hsa049661.71666411
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70183794
23Non-homologous end-joining_Homo sapiens_hsa034501.65632017
24p53 signaling pathway_Homo sapiens_hsa041151.58904618
25mRNA surveillance pathway_Homo sapiens_hsa030151.58576881
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58017084
27Epstein-Barr virus infection_Homo sapiens_hsa051691.57454959
28Protein export_Homo sapiens_hsa030601.39757781
29Purine metabolism_Homo sapiens_hsa002301.33010041
30GABAergic synapse_Homo sapiens_hsa047271.31636341
31Herpes simplex infection_Homo sapiens_hsa051681.21599590
32Legionellosis_Homo sapiens_hsa051341.16944460
33Morphine addiction_Homo sapiens_hsa050321.13638209
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13123737
35Dopaminergic synapse_Homo sapiens_hsa047281.12143173
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06198891
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06168583
38Glutamatergic synapse_Homo sapiens_hsa047241.00849072
39Antigen processing and presentation_Homo sapiens_hsa046120.98753035
40Allograft rejection_Homo sapiens_hsa053300.98569528
41Oocyte meiosis_Homo sapiens_hsa041140.92174028
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91871063
43Primary immunodeficiency_Homo sapiens_hsa053400.91693753
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90850235
45Viral carcinogenesis_Homo sapiens_hsa052030.90399411
46Huntingtons disease_Homo sapiens_hsa050160.88703098
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88607472
48Circadian entrainment_Homo sapiens_hsa047130.88536356
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.86784593
50Olfactory transduction_Homo sapiens_hsa047400.84637279
51Measles_Homo sapiens_hsa051620.84606925
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83239816
53Parkinsons disease_Homo sapiens_hsa050120.82115515
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81405091
55Shigellosis_Homo sapiens_hsa051310.79261041
56Chemokine signaling pathway_Homo sapiens_hsa040620.77738812
57Oxidative phosphorylation_Homo sapiens_hsa001900.77253000
58Cardiac muscle contraction_Homo sapiens_hsa042600.75205581
59Leishmaniasis_Homo sapiens_hsa051400.74016775
60Folate biosynthesis_Homo sapiens_hsa007900.72979781
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.72636254
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72581289
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72562153
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71689370
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69971067
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69879459
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68693272
68Thyroid cancer_Homo sapiens_hsa052160.67201530
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66934507
70Influenza A_Homo sapiens_hsa051640.66864046
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.65176437
72Apoptosis_Homo sapiens_hsa042100.64782073
73Propanoate metabolism_Homo sapiens_hsa006400.64510238
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64335999
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64327760
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64299729
77Sulfur relay system_Homo sapiens_hsa041220.63611550
78Regulation of autophagy_Homo sapiens_hsa041400.63477371
79Amphetamine addiction_Homo sapiens_hsa050310.62331798
80Graft-versus-host disease_Homo sapiens_hsa053320.60315583
81HTLV-I infection_Homo sapiens_hsa051660.59734801
82Carbon metabolism_Homo sapiens_hsa012000.58783411
83Pentose phosphate pathway_Homo sapiens_hsa000300.58346117
84Long-term potentiation_Homo sapiens_hsa047200.58139550
85Peroxisome_Homo sapiens_hsa041460.58060811
86Systemic lupus erythematosus_Homo sapiens_hsa053220.54606403
87Viral myocarditis_Homo sapiens_hsa054160.52372400
88Cholinergic synapse_Homo sapiens_hsa047250.52149751
89Long-term depression_Homo sapiens_hsa047300.50529748
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49106188
91Type I diabetes mellitus_Homo sapiens_hsa049400.48815536
92Non-small cell lung cancer_Homo sapiens_hsa052230.46276577
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46168486
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45209581
95Fatty acid elongation_Homo sapiens_hsa000620.45180756
96Osteoclast differentiation_Homo sapiens_hsa043800.43457218
97Butanoate metabolism_Homo sapiens_hsa006500.42603477
98Asthma_Homo sapiens_hsa053100.42127207
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41557060
100Autoimmune thyroid disease_Homo sapiens_hsa053200.41303377
101Hepatitis B_Homo sapiens_hsa051610.41234602
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41002738
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40692076
104Hematopoietic cell lineage_Homo sapiens_hsa046400.40077073
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39985426
106Phototransduction_Homo sapiens_hsa047440.39189466
107MicroRNAs in cancer_Homo sapiens_hsa052060.39095259
108Colorectal cancer_Homo sapiens_hsa052100.38246026
109Endocytosis_Homo sapiens_hsa041440.37439005
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.36633906
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35981562
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35805126
113Glutathione metabolism_Homo sapiens_hsa004800.35442839
114Taste transduction_Homo sapiens_hsa047420.35175496
115Vitamin B6 metabolism_Homo sapiens_hsa007500.34991978
116Pancreatic cancer_Homo sapiens_hsa052120.34369588
117TGF-beta signaling pathway_Homo sapiens_hsa043500.34267218
118Biosynthesis of amino acids_Homo sapiens_hsa012300.33592718
119Phagosome_Homo sapiens_hsa041450.33098427
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32620043
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31395826
122Arachidonic acid metabolism_Homo sapiens_hsa005900.31275778
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30205046
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29844933
125N-Glycan biosynthesis_Homo sapiens_hsa005100.28060810
126TNF signaling pathway_Homo sapiens_hsa046680.27514797
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24132591
128Acute myeloid leukemia_Homo sapiens_hsa052210.23651214
129Chronic myeloid leukemia_Homo sapiens_hsa052200.23417334
130Vibrio cholerae infection_Homo sapiens_hsa051100.23156873
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22673514
132Tuberculosis_Homo sapiens_hsa051520.22325560
133Other glycan degradation_Homo sapiens_hsa005110.22225523
134Alzheimers disease_Homo sapiens_hsa050100.21839731
135Small cell lung cancer_Homo sapiens_hsa052220.21639687
136Rheumatoid arthritis_Homo sapiens_hsa053230.21268144
137B cell receptor signaling pathway_Homo sapiens_hsa046620.20989864
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.18767261
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17094698
140Alcoholism_Homo sapiens_hsa050340.16413420
141Toxoplasmosis_Homo sapiens_hsa051450.16227455

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