ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of multicellular organism growth (GO:0040015)	4.61846109
2	sex differentiation (GO:0007548)	4.53328404
3	neural tube formation (GO:0001841)	4.09838153
4	behavioral response to nicotine (GO:0035095)	4.06511799
5	piRNA metabolic process (GO:0034587)	4.03259517
6	regulation of memory T cell differentiation (GO:0043380)	3.87612564
7	tryptophan catabolic process (GO:0006569)	3.84240989
8	indole-containing compound catabolic process (GO:0042436)	3.84240989
9	indolalkylamine catabolic process (GO:0046218)	3.84240989
10	fucose catabolic process (GO:0019317)	3.68799157
11	L-fucose metabolic process (GO:0042354)	3.68799157
12	L-fucose catabolic process (GO:0042355)	3.68799157
13	iron-sulfur cluster assembly (GO:0016226)	3.67585265
14	metallo-sulfur cluster assembly (GO:0031163)	3.67585265
15	seminiferous tubule development (GO:0072520)	3.46170235
16	ubiquinone metabolic process (GO:0006743)	3.45355986
17	male meiosis I (GO:0007141)	3.43938942
18	somite rostral/caudal axis specification (GO:0032525)	3.40754496
19	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.39831243
20	kynurenine metabolic process (GO:0070189)	3.38334982
21	regulation of meiosis I (GO:0060631)	3.33104594
22	tryptophan metabolic process (GO:0006568)	3.25541749
23	protein-cofactor linkage (GO:0018065)	3.24610542
24	regulation of neurotransmitter uptake (GO:0051580)	3.18009454
25	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.15818579
26	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.15818579
27	histone H2A acetylation (GO:0043968)	3.03321680
28	synaptic transmission, cholinergic (GO:0007271)	3.02213591
29	indolalkylamine metabolic process (GO:0006586)	3.02176224
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.01628627
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.01144043
32	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.98191562
33	DNA methylation involved in gamete generation (GO:0043046)	2.97920626
34	detection of light stimulus involved in visual perception (GO:0050908)	2.95066840
35	detection of light stimulus involved in sensory perception (GO:0050962)	2.95066840
36	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.94503636
37	postsynaptic membrane organization (GO:0001941)	2.93643950
38	GMP metabolic process (GO:0046037)	2.93356350
39	regulation of action potential (GO:0098900)	2.91940917
40	male meiosis (GO:0007140)	2.89962341
41	glycerophospholipid catabolic process (GO:0046475)	2.87600732
42	protein complex biogenesis (GO:0070271)	2.84616370
43	head development (GO:0060322)	2.83004248
44	pyrimidine nucleobase catabolic process (GO:0006208)	2.82421038
45	nonmotile primary cilium assembly (GO:0035058)	2.81087229
46	nucleobase catabolic process (GO:0046113)	2.80157745
47	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.79897703
48	positive regulation of meiosis (GO:0045836)	2.79365424
49	cornea development in camera-type eye (GO:0061303)	2.75925695
50	reflex (GO:0060004)	2.74765142
51	neuronal action potential (GO:0019228)	2.74398447
52	signal peptide processing (GO:0006465)	2.73344897
53	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.72987964
54	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.72987964
55	negative regulation of telomere maintenance (GO:0032205)	2.72985858
56	cysteine metabolic process (GO:0006534)	2.72541422
57	transmission of nerve impulse (GO:0019226)	2.71230605
58	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.70325689
59	rhodopsin mediated signaling pathway (GO:0016056)	2.69872341
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.69862718
61	regulation of hippo signaling (GO:0035330)	2.69272830
62	protein localization to cilium (GO:0061512)	2.69201719
63	cellular ketone body metabolic process (GO:0046950)	2.68342848
64	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.68133412
65	axoneme assembly (GO:0035082)	2.67768246
66	response to pheromone (GO:0019236)	2.67703404
67	neuronal action potential propagation (GO:0019227)	2.66719578
68	indole-containing compound metabolic process (GO:0042430)	2.66548795
69	regulation of cilium movement (GO:0003352)	2.65241920
70	positive regulation of meiotic cell cycle (GO:0051446)	2.65111549
71	cilium morphogenesis (GO:0060271)	2.63674017
72	somite development (GO:0061053)	2.63529838
73	behavioral response to ethanol (GO:0048149)	2.63313377
74	C4-dicarboxylate transport (GO:0015740)	2.62448689
75	ubiquinone biosynthetic process (GO:0006744)	2.61709979
76	negative regulation of appetite (GO:0032099)	2.61346982
77	negative regulation of response to food (GO:0032096)	2.61346982
78	regulation of establishment of cell polarity (GO:2000114)	2.60606998
79	peristalsis (GO:0030432)	2.54472080
80	water-soluble vitamin biosynthetic process (GO:0042364)	2.54448786
81	dopamine transport (GO:0015872)	2.52798953
82	meiosis I (GO:0007127)	2.52338865
83	neuron fate specification (GO:0048665)	2.52205761
84	amino acid salvage (GO:0043102)	2.52178177
85	L-methionine salvage (GO:0071267)	2.52178177
86	L-methionine biosynthetic process (GO:0071265)	2.52178177
87	embryonic epithelial tube formation (GO:0001838)	2.52037060
88	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.52009376
89	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.52009376
90	NADH dehydrogenase complex assembly (GO:0010257)	2.52009376
91	sympathetic nervous system development (GO:0048485)	2.51414634
92	acrosome reaction (GO:0007340)	2.49995218
93	sulfate transport (GO:0008272)	2.49132852
94	synapsis (GO:0007129)	2.48732114
95	negative regulation of mast cell activation (GO:0033004)	2.48567139
96	pseudouridine synthesis (GO:0001522)	2.48427504
97	mesoderm development (GO:0007498)	2.47908657
98	photoreceptor cell maintenance (GO:0045494)	2.47319940
99	negative regulation of heart rate (GO:0010459)	2.47140432
100	gonadal mesoderm development (GO:0007506)	16.2882174

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.71999051
2	VDR_22108803_ChIP-Seq_LS180_Human	3.66223469
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.16457674
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.03597775
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.93509984
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.89457758
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.80858960
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.60505195
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52368610
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27163871
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.26458747
12	FUS_26573619_Chip-Seq_HEK293_Human	2.25169064
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21089562
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.16338786
15	P300_19829295_ChIP-Seq_ESCs_Human	1.87754320
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.86149543
17	EWS_26573619_Chip-Seq_HEK293_Human	1.82512521
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.81939813
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.81059770
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80701848
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78728107
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.77441346
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.75830042
24	GATA1_22025678_ChIP-Seq_K562_Human	1.73604523
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72532073
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66565270
27	STAT3_23295773_ChIP-Seq_U87_Human	1.63694215
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.63058803
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60645450
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57586794
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56352676
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54543870
33	AR_25329375_ChIP-Seq_VCAP_Human	1.54234482
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53999145
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53916128
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52924541
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52843799
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52234863
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.52234863
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49544822
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49520324
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.48570833
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48133819
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48133819
45	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47333066
46	TCF4_23295773_ChIP-Seq_U87_Human	1.42832833
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42809819
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42809819
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.39270431
50	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.38051408
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37849912
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37251152
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36830245
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36712480
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34409330
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34018714
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33490397
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30079362
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29651119
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.29477927
61	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.28597435
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27714270
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25718895
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25372035
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.25051487
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24560375
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23648646
68	NCOR_22424771_ChIP-Seq_293T_Human	1.20857301
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17214225
70	RXR_22108803_ChIP-Seq_LS180_Human	1.17072004
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16820748
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16682387
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16204336
74	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.15922175
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.11164748
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.09375839
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08963171
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.08114929
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07481522
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06627368
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06627368
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06584223
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05266213
84	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05260498
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05204164
86	AR_20517297_ChIP-Seq_VCAP_Human	1.03578839
87	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02974511
88	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02393495
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02316539
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01146095
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00625516
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00297381
93	AR_21572438_ChIP-Seq_LNCaP_Human	0.97947231
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.97083306
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96528683
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95825213
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94842504
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94522440
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93982781
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93851780

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.66559274
2	MP0000569_abnormal_digit_pigmentation	3.45531244
3	MP0005174_abnormal_tail_pigmentation	2.68962007
4	MP0001986_abnormal_taste_sensitivity	2.67692829
5	MP0002736_abnormal_nociception_after	2.59708577
6	MP0002102_abnormal_ear_morphology	2.55828358
7	MP0003136_yellow_coat_color	2.55464983
8	MP0001968_abnormal_touch/_nociception	2.50016105
9	MP0004885_abnormal_endolymph	2.49376574
10	MP0005551_abnormal_eye_electrophysiolog	2.39786876
11	MP0003011_delayed_dark_adaptation	2.19244462
12	MP0003646_muscle_fatigue	2.16492427
13	MP0009379_abnormal_foot_pigmentation	2.09136956
14	MP0009046_muscle_twitch	1.96680528
15	MP0001984_abnormal_olfaction	1.91172587
16	MP0000372_irregular_coat_pigmentation	1.88935609
17	MP0009745_abnormal_behavioral_response	1.87221031
18	MP0003880_abnormal_central_pattern	1.82818230
19	MP0000427_abnormal_hair_cycle	1.81405211
20	MP0008877_abnormal_DNA_methylation	1.81278904
21	MP0002638_abnormal_pupillary_reflex	1.78981949
22	MP0002272_abnormal_nervous_system	1.76287378
23	MP0005645_abnormal_hypothalamus_physiol	1.75956571
24	MP0001486_abnormal_startle_reflex	1.72334638
25	MP0005253_abnormal_eye_physiology	1.70306779
26	MP0002095_abnormal_skin_pigmentation	1.70159340
27	MP0003195_calcinosis	1.68638058
28	MP0005423_abnormal_somatic_nervous	1.64137752
29	MP0006072_abnormal_retinal_apoptosis	1.63724955
30	MP0000647_abnormal_sebaceous_gland	1.62862564
31	MP0002733_abnormal_thermal_nociception	1.61054187
32	MP0002735_abnormal_chemical_nociception	1.59466440
33	MP0006035_abnormal_mitochondrial_morpho	1.59405483
34	MP0002653_abnormal_ependyma_morphology	1.57605604
35	MP0000631_abnormal_neuroendocrine_gland	1.54232595
36	MP0000015_abnormal_ear_pigmentation	1.50629866
37	MP0004142_abnormal_muscle_tone	1.45544784
38	MP0001529_abnormal_vocalization	1.44829106
39	MP0003890_abnormal_embryonic-extraembry	1.44552256
40	MP0002064_seizures	1.43890800
41	MP0003252_abnormal_bile_duct	1.42859550
42	MP0002163_abnormal_gland_morphology	1.42159355
43	MP0002837_dystrophic_cardiac_calcinosis	1.41336978
44	MP0002938_white_spotting	1.41121309
45	MP0002572_abnormal_emotion/affect_behav	1.39903254
46	MP0002751_abnormal_autonomic_nervous	1.38461501
47	MP0001970_abnormal_pain_threshold	1.36335126
48	MP0003878_abnormal_ear_physiology	1.30341373
49	MP0005377_hearing/vestibular/ear_phenot	1.30341373
50	MP0001485_abnormal_pinna_reflex	1.28834670
51	MP0002557_abnormal_social/conspecific_i	1.26781554
52	MP0005646_abnormal_pituitary_gland	1.24867692
53	MP0008058_abnormal_DNA_repair	1.24751933
54	MP0001188_hyperpigmentation	1.20312841
55	MP0003635_abnormal_synaptic_transmissio	1.19386925
56	MP0002734_abnormal_mechanical_nocicepti	1.18904880
57	MP0003718_maternal_effect	1.16635296
58	MP0005084_abnormal_gallbladder_morpholo	1.13964157
59	MP0000383_abnormal_hair_follicle	1.12924893
60	MP0002067_abnormal_sensory_capabilities	1.12618531
61	MP0005187_abnormal_penis_morphology	1.11722442
62	MP0005075_abnormal_melanosome_morpholog	1.11431191
63	MP0001501_abnormal_sleep_pattern	1.11007393
64	MP0009840_abnormal_foam_cell	1.09081240
65	MP0002229_neurodegeneration	1.08224331
66	MP0004924_abnormal_behavior	1.08146445
67	MP0005386_behavior/neurological_phenoty	1.08146445
68	MP0000371_diluted_coat_color	1.08124256
69	MP0004742_abnormal_vestibular_system	1.06578297
70	MP0003698_abnormal_male_reproductive	1.06198228
71	MP0006276_abnormal_autonomic_nervous	1.04763711
72	MP0002063_abnormal_learning/memory/cond	1.04173455
73	MP0002184_abnormal_innervation	1.02403964
74	MP0001929_abnormal_gametogenesis	1.01114680
75	MP0008872_abnormal_physiological_respon	1.00712452
76	MP0005410_abnormal_fertilization	1.00441045
77	MP0004134_abnormal_chest_morphology	0.96831858
78	MP0005379_endocrine/exocrine_gland_phen	0.95707768
79	MP0005171_absent_coat_pigmentation	0.95656773
80	MP0002210_abnormal_sex_determination	0.93609132
81	MP0008057_abnormal_DNA_replication	0.93280485
82	MP0008961_abnormal_basal_metabolism	0.92424367
83	MP0005167_abnormal_blood-brain_barrier	0.92315266
84	MP0000653_abnormal_sex_gland	0.92227567
85	MP0004215_abnormal_myocardial_fiber	0.91877307
86	MP0001145_abnormal_male_reproductive	0.90865379
87	MP0003137_abnormal_impulse_conducting	0.89574357
88	MP0004043_abnormal_pH_regulation	0.88747905
89	MP0008995_early_reproductive_senescence	0.86896355
90	MP0001324_abnormal_eye_pigmentation	0.86525502
91	MP0008875_abnormal_xenobiotic_pharmacok	0.85964971
92	MP0001963_abnormal_hearing_physiology	0.85637469
93	MP0004133_heterotaxia	0.84887003
94	MP0000026_abnormal_inner_ear	0.84589100
95	MP0004270_analgesia	0.82713801
96	MP0000778_abnormal_nervous_system	0.82026892
97	MP0003119_abnormal_digestive_system	0.80379540
98	MP0002234_abnormal_pharynx_morphology	0.80039459
99	MP0003183_abnormal_peptide_metabolism	0.79367112
100	MP0002752_abnormal_somatic_nervous	0.79211523

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.18473806
2	Attenuation of retinal blood vessels (HP:0007843)	3.97164909
3	Pendular nystagmus (HP:0012043)	3.81001016
4	Congenital stationary night blindness (HP:0007642)	3.79496556
5	Pancreatic fibrosis (HP:0100732)	3.72378650
6	True hermaphroditism (HP:0010459)	3.66069155
7	Increased corneal curvature (HP:0100692)	3.59118448
8	Keratoconus (HP:0000563)	3.59118448
9	Hyperventilation (HP:0002883)	3.57421911
10	Molar tooth sign on MRI (HP:0002419)	3.54389150
11	Abnormality of midbrain morphology (HP:0002418)	3.54389150
12	Decreased central vision (HP:0007663)	3.41057694
13	Type II lissencephaly (HP:0007260)	3.36236739
14	Abolished electroretinogram (ERG) (HP:0000550)	3.17819570
15	Focal motor seizures (HP:0011153)	3.08933573
16	Genetic anticipation (HP:0003743)	3.04971625
17	Birth length less than 3rd percentile (HP:0003561)	3.01819499
18	Hemiparesis (HP:0001269)	2.98712577
19	Action tremor (HP:0002345)	2.95306951
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.90804924
21	Bony spicule pigmentary retinopathy (HP:0007737)	2.90504551
22	Inability to walk (HP:0002540)	2.89534052
23	Chronic hepatic failure (HP:0100626)	2.80952677
24	Lissencephaly (HP:0001339)	2.72660651
25	Nephronophthisis (HP:0000090)	2.72034698
26	Progressive cerebellar ataxia (HP:0002073)	2.67266030
27	Progressive inability to walk (HP:0002505)	2.61814421
28	Dialeptic seizures (HP:0011146)	2.59559070
29	Focal seizures (HP:0007359)	2.55569873
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.51644417
31	Medial flaring of the eyebrow (HP:0010747)	2.50656734
32	Gaze-evoked nystagmus (HP:0000640)	2.48154289
33	Absence seizures (HP:0002121)	2.47857148
34	Abnormality of macular pigmentation (HP:0008002)	2.42592637
35	Abnormality of the renal cortex (HP:0011035)	2.41251915
36	Fair hair (HP:0002286)	2.40543039
37	Cerebellar dysplasia (HP:0007033)	2.36482363
38	Febrile seizures (HP:0002373)	2.33810488
39	Cystic liver disease (HP:0006706)	2.31575457
40	Abnormal mitochondria in muscle tissue (HP:0008316)	2.31559814
41	Sclerocornea (HP:0000647)	2.30584054
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25632015
43	Abnormality of the renal medulla (HP:0100957)	2.23259666
44	Retinal dysplasia (HP:0007973)	2.23241480
45	Acute necrotizing encephalopathy (HP:0006965)	2.22494749
46	Optic nerve hypoplasia (HP:0000609)	2.21398552
47	Ulnar claw (HP:0001178)	2.20678694
48	Broad-based gait (HP:0002136)	2.19919700
49	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19755167
50	Prostate neoplasm (HP:0100787)	2.14841486
51	Severe visual impairment (HP:0001141)	2.05005873
52	Tubular atrophy (HP:0000092)	2.02035254
53	Gait imbalance (HP:0002141)	2.00948787
54	Congenital primary aphakia (HP:0007707)	2.00549154
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.00217148
56	Patellar aplasia (HP:0006443)	1.98946104
57	Furrowed tongue (HP:0000221)	1.97514652
58	Male pseudohermaphroditism (HP:0000037)	1.94925153
59	Generalized aminoaciduria (HP:0002909)	1.94614337
60	Hypoplasia of the uterus (HP:0000013)	1.93350320
61	Increased CSF lactate (HP:0002490)	1.92669578
62	Acute encephalopathy (HP:0006846)	1.92473192
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.92385784
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.92385784
65	Retinitis pigmentosa (HP:0000510)	1.91624537
66	Progressive macrocephaly (HP:0004481)	1.90009728
67	Mitochondrial inheritance (HP:0001427)	1.89350320
68	Genital tract atresia (HP:0001827)	1.89282695
69	Hyperglycinuria (HP:0003108)	1.89079608
70	Colon cancer (HP:0003003)	1.88743651
71	Large for gestational age (HP:0001520)	1.88594959
72	Aplasia/Hypoplasia of the patella (HP:0006498)	1.88341179
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87681261
74	Ependymoma (HP:0002888)	1.86950403
75	Optic disc pallor (HP:0000543)	1.85699608
76	Generalized hypopigmentation of hair (HP:0011358)	1.82628110
77	Absent speech (HP:0001344)	1.81233985
78	Methylmalonic acidemia (HP:0002912)	1.79428702
79	Female pseudohermaphroditism (HP:0010458)	1.79076224
80	Macular degeneration (HP:0000608)	1.78171453
81	Vaginal atresia (HP:0000148)	1.77945144
82	Glycosuria (HP:0003076)	1.77134108
83	Abnormality of urine glucose concentration (HP:0011016)	1.77134108
84	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.75888238
85	Clumsiness (HP:0002312)	1.75666770
86	Urinary bladder sphincter dysfunction (HP:0002839)	1.74578073
87	Methylmalonic aciduria (HP:0012120)	1.74379237
88	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74012238
89	Nephrogenic diabetes insipidus (HP:0009806)	1.73759997
90	Congenital sensorineural hearing impairment (HP:0008527)	1.73414877
91	Hypoplasia of the fovea (HP:0007750)	1.72471401
92	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.72471401
93	Oculomotor apraxia (HP:0000657)	1.71732304
94	Anencephaly (HP:0002323)	1.69868956
95	Tachypnea (HP:0002789)	1.69752347
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69713576
97	Abnormality of the hepatic vasculature (HP:0006707)	1.69005749
98	Bilateral microphthalmos (HP:0007633)	1.67799643
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.67750960
100	Glioma (HP:0009733)	1.66574446

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.05747754
2	TAOK3	3.47529742
3	BMPR1B	3.26853389
4	INSRR	3.10801161
5	CDK19	2.95040605
6	ACVR1B	2.83684621
7	ADRBK2	2.77470073
8	GRK1	2.25809249
9	OXSR1	2.21513788
10	DAPK2	2.19089968
11	WNK3	2.14847259
12	CAMKK2	2.05854994
13	MAP4K2	1.83664112
14	PNCK	1.83250539
15	TNIK	1.80690064
16	WNK4	1.69916578
17	PINK1	1.69358819
18	EPHA4	1.65207751
19	NUAK1	1.63643558
20	NME1	1.54465973
21	CASK	1.50670262
22	ZAK	1.48751535
23	STK16	1.48644515
24	TGFBR1	1.47830024
25	DYRK2	1.37759617
26	TXK	1.34256675
27	NTRK3	1.28130282
28	MAPK13	1.23206688
29	ADRBK1	1.19889990
30	MAP2K6	1.19364313
31	STK39	1.18576037
32	TAF1	1.10663071
33	CSNK1G3	1.05780659
34	CSNK1G1	1.05666648
35	MAP3K4	1.04965201
36	MKNK2	1.04512274
37	CSNK1A1L	1.03953802
38	CSNK1G2	1.03952007
39	CAMK1G	0.97185262
40	PTK2B	0.95965278
41	PAK3	0.91351454
42	PRKCG	0.89381085
43	NTRK2	0.89234926
44	BCR	0.86840869
45	PIK3CG	0.82446042
46	MUSK	0.81851963
47	NEK1	0.80762289
48	BRSK2	0.80457010
49	CAMK1D	0.80256481
50	STK38L	0.73950560
51	CAMK2A	0.72600183
52	GRK7	0.71331925
53	PRKCE	0.70506110
54	CDC7	0.67834102
55	RPS6KB2	0.64117023
56	MAPKAPK3	0.63868059
57	MAPKAPK5	0.61677319
58	MAP2K7	0.61033042
59	PLK2	0.60198466
60	STK3	0.59086471
61	STK11	0.58493771
62	MARK1	0.57018982
63	SIK2	0.53846584
64	CAMKK1	0.53677039
65	RPS6KA5	0.51941951
66	CHEK2	0.51466245
67	BCKDK	0.51448227
68	PLK3	0.51040271
69	DYRK3	0.50634226
70	ATR	0.50288238
71	VRK2	0.50285524
72	MINK1	0.50060444
73	EIF2AK3	0.49557622
74	PRKACA	0.48857407
75	TEC	0.47756981
76	VRK1	0.47279959
77	ITK	0.47245480
78	MKNK1	0.46656047
79	CSNK1A1	0.45215907
80	PHKG1	0.45169601
81	PHKG2	0.45169601
82	PIK3CA	0.43871565
83	CDK3	0.43557932
84	MST4	0.41338120
85	IKBKB	0.40772707
86	MAP3K7	0.40710461
87	RPS6KB1	0.39670775
88	NLK	0.39498436
89	TRIM28	0.39311993
90	TIE1	0.37651348
91	TSSK6	0.37274938
92	CDK8	0.36046942
93	DYRK1A	0.35690642
94	GRK5	0.34718480
95	CAMK1	0.34449246
96	PKN1	0.34427745
97	TLK1	0.34028738
98	CHUK	0.31994407
99	PDK2	0.31651944
100	FLT3	0.30296530

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.35891466
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.95754148
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.69199965
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53334725
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.43144090
6	Protein export_Homo sapiens_hsa03060	2.41230695
7	Butanoate metabolism_Homo sapiens_hsa00650	2.40235625
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.31981191
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.23336962
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.17398744
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.14683287
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.07892727
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.91715422
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.90615376
15	RNA polymerase_Homo sapiens_hsa03020	1.88527364
16	Nicotine addiction_Homo sapiens_hsa05033	1.84037893
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81576427
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74676971
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73769959
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.63962276
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.61016883
22	Taste transduction_Homo sapiens_hsa04742	1.60076331
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.54286798
24	Caffeine metabolism_Homo sapiens_hsa00232	1.53868815
25	ABC transporters_Homo sapiens_hsa02010	1.45212360
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.42403380
27	Olfactory transduction_Homo sapiens_hsa04740	1.35028283
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.34873002
29	Parkinsons disease_Homo sapiens_hsa05012	1.33603528
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.32350004
31	Peroxisome_Homo sapiens_hsa04146	1.30089041
32	Homologous recombination_Homo sapiens_hsa03440	1.26851261
33	Retinol metabolism_Homo sapiens_hsa00830	1.23841540
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.22783078
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.21654505
36	Propanoate metabolism_Homo sapiens_hsa00640	1.20022536
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18420947
38	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15240925
39	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.13134655
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11541123
41	Morphine addiction_Homo sapiens_hsa05032	1.10272610
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.08828222
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04282428
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.99793581
45	Purine metabolism_Homo sapiens_hsa00230	0.96055129
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.95770628
47	GABAergic synapse_Homo sapiens_hsa04727	0.94193306
48	Huntingtons disease_Homo sapiens_hsa05016	0.93545955
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93002380
50	Serotonergic synapse_Homo sapiens_hsa04726	0.89492343
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88376032
52	Insulin secretion_Homo sapiens_hsa04911	0.87435634
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87001463
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85131807
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82987642
56	RNA degradation_Homo sapiens_hsa03018	0.82080823
57	Circadian entrainment_Homo sapiens_hsa04713	0.80525920
58	Regulation of autophagy_Homo sapiens_hsa04140	0.77418833
59	Fatty acid degradation_Homo sapiens_hsa00071	0.76336767
60	Alzheimers disease_Homo sapiens_hsa05010	0.76301905
61	Basal transcription factors_Homo sapiens_hsa03022	0.76221201
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75839101
63	One carbon pool by folate_Homo sapiens_hsa00670	0.74958671
64	Glutathione metabolism_Homo sapiens_hsa00480	0.72019138
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71651967
66	Salivary secretion_Homo sapiens_hsa04970	0.68684230
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67857310
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67827983
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67400442
70	Metabolic pathways_Homo sapiens_hsa01100	0.66239901
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.65296340
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.64073653
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.63105961
74	Cocaine addiction_Homo sapiens_hsa05030	0.61938104
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61651945
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61010209
77	Fatty acid elongation_Homo sapiens_hsa00062	0.59362980
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59300883
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.56690863
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.55928057
81	Histidine metabolism_Homo sapiens_hsa00340	0.55667273
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55573944
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54794012
84	Mineral absorption_Homo sapiens_hsa04978	0.52917484
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52785866
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.51719488
87	Long-term depression_Homo sapiens_hsa04730	0.47687607
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46599711
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46251317
90	Gastric acid secretion_Homo sapiens_hsa04971	0.44669423
91	Renin-angiotensin system_Homo sapiens_hsa04614	0.44363216
92	Circadian rhythm_Homo sapiens_hsa04710	0.42846744
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41895001
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.37310090
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37089761
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36838158
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36418276
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.36237106
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35235901
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32368510

FAM197Y3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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