ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oxygen transport (GO:0015671)	6.47309298
2	central nervous system myelination (GO:0022010)	5.05652467
3	axon ensheathment in central nervous system (GO:0032291)	5.05652467
4	gas transport (GO:0015669)	4.97190418
5	autophagic vacuole fusion (GO:0000046)	4.77110727
6	neutrophil activation involved in immune response (GO:0002283)	4.41426087
7	behavioral response to nicotine (GO:0035095)	4.21231528
8	mesoderm development (GO:0007498)	4.20119600
9	indole-containing compound catabolic process (GO:0042436)	4.07576342
10	indolalkylamine catabolic process (GO:0046218)	4.07576342
11	tryptophan catabolic process (GO:0006569)	4.07576342
12	amine catabolic process (GO:0009310)	3.90264068
13	cellular biogenic amine catabolic process (GO:0042402)	3.90264068
14	mesenchyme development (GO:0060485)	3.84764571
15	kynurenine metabolic process (GO:0070189)	3.83365040
16	cellular response to zinc ion (GO:0071294)	3.83332787
17	sex differentiation (GO:0007548)	3.77950759
18	fucose catabolic process (GO:0019317)	3.63272943
19	L-fucose metabolic process (GO:0042354)	3.63272943
20	L-fucose catabolic process (GO:0042355)	3.63272943
21	tryptophan metabolic process (GO:0006568)	3.59903528
22	indolalkylamine metabolic process (GO:0006586)	3.58186114
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.56845763
24	piRNA metabolic process (GO:0034587)	3.46531424
25	organelle membrane fusion (GO:0090174)	3.44519277
26	negative regulation of astrocyte differentiation (GO:0048712)	3.43678989
27	multicellular organism reproduction (GO:0032504)	3.28131929
28	protein neddylation (GO:0045116)	3.26750552
29	negative regulation of mast cell activation (GO:0033004)	3.23421413
30	signal peptide processing (GO:0006465)	3.18697174
31	negative regulation of heart rate (GO:0010459)	3.17285748
32	regulation of gene silencing by RNA (GO:0060966)	3.15829521
33	regulation of posttranscriptional gene silencing (GO:0060147)	3.15829521
34	regulation of gene silencing by miRNA (GO:0060964)	3.15829521
35	cellular response to cadmium ion (GO:0071276)	3.12796613
36	sulfation (GO:0051923)	3.04230599
37	negative regulation of protein localization to cell surface (GO:2000009)	3.01127494
38	regulation of cilium movement (GO:0003352)	3.00226675
39	gonadal mesoderm development (GO:0007506)	29.0004277
40	protein K11-linked deubiquitination (GO:0035871)	2.97853982
41	regulation of hippo signaling (GO:0035330)	2.97518336
42	positive regulation of meiosis (GO:0045836)	2.95200977
43	aromatic amino acid family catabolic process (GO:0009074)	2.92506754
44	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.91564814
45	thrombin receptor signaling pathway (GO:0070493)	2.85967475
46	fusion of sperm to egg plasma membrane (GO:0007342)	2.84851187
47	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.84748154
48	erythrocyte maturation (GO:0043249)	2.84654119
49	DNA methylation involved in gamete generation (GO:0043046)	2.83317815
50	nucleosome assembly (GO:0006334)	2.81439864
51	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.79906333
52	cullin deneddylation (GO:0010388)	2.78936859
53	N-acetylneuraminate metabolic process (GO:0006054)	2.78540477
54	neural tube formation (GO:0001841)	2.73848149
55	positive regulation of meiotic cell cycle (GO:0051446)	2.70488008
56	neutrophil activation (GO:0042119)	2.70255281
57	endosome to melanosome transport (GO:0035646)	2.68498773
58	endosome to pigment granule transport (GO:0043485)	2.68498773
59	superoxide anion generation (GO:0042554)	2.68047400
60	rhodopsin mediated signaling pathway (GO:0016056)	2.67233749
61	epithelial cilium movement (GO:0003351)	2.64705777
62	left/right axis specification (GO:0070986)	2.64662666
63	platelet dense granule organization (GO:0060155)	2.63844897
64	protein deneddylation (GO:0000338)	2.63800225
65	protein-DNA complex assembly (GO:0065004)	2.63503501
66	male meiosis (GO:0007140)	2.62326707
67	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.62095354
68	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.61679466
69	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.61319968
70	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.61319968
71	indole-containing compound metabolic process (GO:0042430)	2.57464635
72	negative regulation of appetite (GO:0032099)	2.55158677
73	negative regulation of response to food (GO:0032096)	2.55158677
74	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.54304647
75	sleep (GO:0030431)	2.54101255
76	cilium or flagellum-dependent cell motility (GO:0001539)	2.52670387
77	regulation of sensory perception (GO:0051931)	2.51900044
78	regulation of sensory perception of pain (GO:0051930)	2.51900044
79	regulation of guanylate cyclase activity (GO:0031282)	2.50933278
80	alanine transport (GO:0032328)	2.49261927
81	photoreceptor cell maintenance (GO:0045494)	2.48640444
82	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.46232878
83	neuronal action potential (GO:0019228)	2.44318138
84	positive regulation of endothelial cell differentiation (GO:0045603)	2.42975917
85	protein K48-linked deubiquitination (GO:0071108)	2.41533751
86	phagocytosis, recognition (GO:0006910)	2.40436513
87	synapsis (GO:0007129)	2.39972583
88	regulation of microtubule-based movement (GO:0060632)	2.38835292
89	granulocyte activation (GO:0036230)	2.36636871
90	tyrosine metabolic process (GO:0006570)	2.36087070
91	adaptation of signaling pathway (GO:0023058)	2.35619367
92	positive regulation of guanylate cyclase activity (GO:0031284)	2.31917606
93	cilium morphogenesis (GO:0060271)	2.29970499
94	protein-cofactor linkage (GO:0018065)	2.29535623
95	dopamine transport (GO:0015872)	2.28560319
96	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.27967744
97	leukocyte migration involved in inflammatory response (GO:0002523)	2.27328294
98	rRNA catabolic process (GO:0016075)	2.27072430
99	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.26255184
100	synaptic transmission, cholinergic (GO:0007271)	2.23960115

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.43418316
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.37544608
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.33296714
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02176716
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.55232558
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36237835
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.36006218
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30061984
9	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.26847080
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.24372486
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.22035209
12	EWS_26573619_Chip-Seq_HEK293_Human	2.10879315
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06084280
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03624172
15	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.99618288
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.95800538
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85933418
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81191294
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75329862
20	P300_19829295_ChIP-Seq_ESCs_Human	1.72860556
21	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.71022196
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70646571
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69498349
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63080490
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.62834233
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.60383516
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59013769
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56796117
29	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.54693799
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.54693799
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.53349557
32	FUS_26573619_Chip-Seq_HEK293_Human	1.52761238
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52575853
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52575853
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51441859
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.47624016
37	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.41442923
38	STAT3_23295773_ChIP-Seq_U87_Human	1.41190781
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41090195
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.40313983
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39535958
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39308523
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37744147
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37642928
45	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33104308
46	AR_25329375_ChIP-Seq_VCAP_Human	1.31785434
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31307871
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30753449
49	TP53_16413492_ChIP-PET_HCT116_Human	1.30348154
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30160049
51	TCF4_23295773_ChIP-Seq_U87_Human	1.29698175
52	AR_20517297_ChIP-Seq_VCAP_Human	1.29298343
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29027060
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29027060
55	HTT_18923047_ChIP-ChIP_STHdh_Human	1.27978213
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.26134941
57	JUN_21703547_ChIP-Seq_K562_Human	1.25662108
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25362815
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.22743161
60	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.22127202
61	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.22088245
62	GATA1_19941826_ChIP-Seq_K562_Human	1.20024942
63	GATA1_22025678_ChIP-Seq_K562_Human	1.19377795
64	GATA2_19941826_ChIP-Seq_K562_Human	1.18840412
65	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.18663740
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18260332
67	SCL_19346495_ChIP-Seq_HPC-7_Human	1.18167407
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.18123953
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.15650937
70	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.14886583
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11355502
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10450839
73	DROSHA_22980978_ChIP-Seq_HELA_Human	1.07739878
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06860067
75	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.06769933
76	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.06769933
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06622637
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06137266
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05735255
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05042153
81	GATA3_26560356_Chip-Seq_TH1_Human	1.04754828
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03268808
83	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03141829
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02568071
85	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01998287
86	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01562196
87	CBP_20019798_ChIP-Seq_JUKART_Human	1.01562196
88	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00364147
89	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.99983212
90	GATA3_26560356_Chip-Seq_TH2_Human	0.99643947
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99223913
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99027910
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98534084
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98392390
95	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.97381738
96	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97087324
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96790141
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96071437
99	NCOR_22424771_ChIP-Seq_293T_Human	0.94369916
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.94008471

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	7.71239360
2	MP0005464_abnormal_platelet_physiology	3.20301137
3	MP0003195_calcinosis	2.26019831
4	MP0001485_abnormal_pinna_reflex	2.14604461
5	MP0008877_abnormal_DNA_methylation	2.12125797
6	MP0005410_abnormal_fertilization	2.11780235
7	MP0003011_delayed_dark_adaptation	2.09648950
8	MP0005174_abnormal_tail_pigmentation	2.06573395
9	MP0005171_absent_coat_pigmentation	2.04381928
10	MP0005551_abnormal_eye_electrophysiolog	1.88425662
11	MP0000383_abnormal_hair_follicle	1.81035921
12	MP0004147_increased_porphyrin_level	1.78212741
13	MP0000230_abnormal_systemic_arterial	1.76400878
14	MP0008875_abnormal_xenobiotic_pharmacok	1.75491266
15	MP0004130_abnormal_muscle_cell	1.74734419
16	MP0005253_abnormal_eye_physiology	1.70034737
17	MP0000372_irregular_coat_pigmentation	1.69670511
18	MP0004043_abnormal_pH_regulation	1.67151689
19	MP0004885_abnormal_endolymph	1.60470635
20	MP0004215_abnormal_myocardial_fiber	1.59676456
21	MP0002837_dystrophic_cardiac_calcinosis	1.58910304
22	MP0005377_hearing/vestibular/ear_phenot	1.57763647
23	MP0003878_abnormal_ear_physiology	1.57763647
24	MP0008872_abnormal_physiological_respon	1.56711981
25	MP0009745_abnormal_behavioral_response	1.51762433
26	MP0006072_abnormal_retinal_apoptosis	1.48083792
27	MP0008058_abnormal_DNA_repair	1.46935616
28	MP0004142_abnormal_muscle_tone	1.45297640
29	MP0002638_abnormal_pupillary_reflex	1.44094731
30	MP0002736_abnormal_nociception_after	1.41354549
31	MP0001968_abnormal_touch/_nociception	1.39662073
32	MP0009046_muscle_twitch	1.38239082
33	MP0005645_abnormal_hypothalamus_physiol	1.37855607
34	MP0003724_increased_susceptibility_to	1.37078407
35	MP0003303_peritoneal_inflammation	1.34438373
36	MP0003718_maternal_effect	1.34229027
37	MP0000343_altered_response_to	1.33509700
38	MP0000569_abnormal_digit_pigmentation	1.31499595
39	MP0002735_abnormal_chemical_nociception	1.31328764
40	MP0000427_abnormal_hair_cycle	1.29279830
41	MP0008775_abnormal_heart_ventricle	1.28243728
42	MP0000647_abnormal_sebaceous_gland	1.27660930
43	MP0004742_abnormal_vestibular_system	1.27193325
44	MP0002653_abnormal_ependyma_morphology	1.26779188
45	MP0010386_abnormal_urinary_bladder	1.26019560
46	MP0002272_abnormal_nervous_system	1.25848294
47	MP0008995_early_reproductive_senescence	1.25320426
48	MP0002277_abnormal_respiratory_mucosa	1.24679891
49	MP0001879_abnormal_lymphatic_vessel	1.21401424
50	MP0002928_abnormal_bile_duct	1.20518102
51	MP0002938_white_spotting	1.20014079
52	MP0002095_abnormal_skin_pigmentation	1.19820889
53	MP0004133_heterotaxia	1.19670549
54	MP0003656_abnormal_erythrocyte_physiolo	1.18092729
55	MP0005084_abnormal_gallbladder_morpholo	1.17237468
56	MP0001501_abnormal_sleep_pattern	1.15208617
57	MP0004381_abnormal_hair_follicle	1.13957617
58	MP0006292_abnormal_olfactory_placode	1.11691364
59	MP0008004_abnormal_stomach_pH	1.11263280
60	MP0005365_abnormal_bile_salt	1.10562636
61	MP0003252_abnormal_bile_duct	1.07727654
62	MP0005646_abnormal_pituitary_gland	1.07189707
63	MP0005083_abnormal_biliary_tract	1.06911142
64	MP0001984_abnormal_olfaction	1.01014901
65	MP0001929_abnormal_gametogenesis	1.00707182
66	MP0003698_abnormal_male_reproductive	0.98993255
67	MP0003186_abnormal_redox_activity	0.98166312
68	MP0002067_abnormal_sensory_capabilities	0.97884688
69	MP0005075_abnormal_melanosome_morpholog	0.97818582
70	MP0002064_seizures	0.97713638
71	MP0001663_abnormal_digestive_system	0.97367707
72	MP0000631_abnormal_neuroendocrine_gland	0.95357524
73	MP0002148_abnormal_hypersensitivity_rea	0.94274518
74	MP0010329_abnormal_lipoprotein_level	0.93298629
75	MP0010678_abnormal_skin_adnexa	0.93159423
76	MP0003646_muscle_fatigue	0.89303303
77	MP0001970_abnormal_pain_threshold	0.88721009
78	MP0003638_abnormal_response/metabolism_	0.87846789
79	MP0002733_abnormal_thermal_nociception	0.87754653
80	MP0004134_abnormal_chest_morphology	0.87583669
81	MP0002229_neurodegeneration	0.87317189
82	MP0002876_abnormal_thyroid_physiology	0.87301246
83	MP0009764_decreased_sensitivity_to	0.87155464
84	MP0005332_abnormal_amino_acid	0.86588973
85	MP0006276_abnormal_autonomic_nervous	0.85622614
86	MP0000465_gastrointestinal_hemorrhage	0.85074867
87	MP0003890_abnormal_embryonic-extraembry	0.84288200
88	MP0001765_abnormal_ion_homeostasis	0.83250946
89	MP0002210_abnormal_sex_determination	0.83237551
90	MP0009780_abnormal_chondrocyte_physiolo	0.82155580
91	MP0009379_abnormal_foot_pigmentation	0.80407328
92	MP0003950_abnormal_plasma_membrane	0.80076279
93	MP0001486_abnormal_startle_reflex	0.79521743
94	MP0001664_abnormal_digestion	0.79076871
95	MP0005085_abnormal_gallbladder_physiolo	0.70836639
96	MP0006036_abnormal_mitochondrial_physio	0.69064434
97	MP0001756_abnormal_urination	0.68582060
98	MP0000026_abnormal_inner_ear	0.68396120
99	MP0002572_abnormal_emotion/affect_behav	0.68045190
100	MP0008569_lethality_at_weaning	0.67157370

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hemoglobin (HP:0011902)	5.60051050
2	Pancreatic cysts (HP:0001737)	4.12190353
3	Pancreatic fibrosis (HP:0100732)	4.04270110
4	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.84647365
5	True hermaphroditism (HP:0010459)	3.70176842
6	Congenital, generalized hypertrichosis (HP:0004540)	3.62042749
7	Prolonged bleeding time (HP:0003010)	3.59365181
8	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.54370760
9	Abnormality of midbrain morphology (HP:0002418)	3.52124344
10	Molar tooth sign on MRI (HP:0002419)	3.52124344
11	Chronic hepatic failure (HP:0100626)	3.43853551
12	Cystic liver disease (HP:0006706)	3.23637101
13	Type II lissencephaly (HP:0007260)	3.20785574
14	Menorrhagia (HP:0000132)	3.16080716
15	Concave nail (HP:0001598)	3.10754583
16	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.08720759
17	Hyperlipoproteinemia (HP:0010980)	3.04535838
18	Nephronophthisis (HP:0000090)	3.03199228
19	Increased cerebral lipofuscin (HP:0011813)	2.92188180
20	Increased mean platelet volume (HP:0011877)	2.88490694
21	Congenital stationary night blindness (HP:0007642)	2.88048042
22	Abnormality of the renal cortex (HP:0011035)	2.87103298
23	Absent/shortened dynein arms (HP:0200106)	2.80588385
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.80588385
25	Furrowed tongue (HP:0000221)	2.77894484
26	Sclerocornea (HP:0000647)	2.77031115
27	Bile duct proliferation (HP:0001408)	2.75727341
28	Abnormal biliary tract physiology (HP:0012439)	2.75727341
29	Abnormality of the renal medulla (HP:0100957)	2.74640008
30	Large for gestational age (HP:0001520)	2.71140458
31	Abnormality of the pons (HP:0007361)	2.64089332
32	Conical tooth (HP:0000698)	2.59154389
33	Abnormal platelet volume (HP:0011876)	2.58108876
34	Stomach cancer (HP:0012126)	2.55026025
35	Hypoplastic iliac wings (HP:0002866)	2.53539459
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.51766142
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.51766142
38	Abolished electroretinogram (ERG) (HP:0000550)	2.48470557
39	Abnormal auditory evoked potentials (HP:0006958)	2.46926402
40	Duplicated collecting system (HP:0000081)	2.45917061
41	Purpura (HP:0000979)	2.45106263
42	Abnormal number of erythroid precursors (HP:0012131)	2.38967481
43	Abnormality of alanine metabolism (HP:0010916)	2.37697082
44	Hyperalaninemia (HP:0003348)	2.37697082
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.37697082
46	Hyperglycinuria (HP:0003108)	2.34222223
47	Clumsiness (HP:0002312)	2.31431286
48	Polydipsia (HP:0001959)	2.26442773
49	Abnormal drinking behavior (HP:0030082)	2.26442773
50	Hypoplasia of the pons (HP:0012110)	2.26398716
51	Renal cortical cysts (HP:0000803)	2.26023010
52	Anencephaly (HP:0002323)	2.23328322
53	Epistaxis (HP:0000421)	2.17147531
54	Inability to walk (HP:0002540)	2.17145068
55	Abnormality of the renal collecting system (HP:0004742)	2.16286706
56	Tubular atrophy (HP:0000092)	2.15085614
57	Male pseudohermaphroditism (HP:0000037)	2.12345145
58	Hyperventilation (HP:0002883)	2.11132128
59	Cerebellar dysplasia (HP:0007033)	2.08141458
60	Lissencephaly (HP:0001339)	2.07526337
61	Female pseudohermaphroditism (HP:0010458)	2.07182751
62	Bilateral microphthalmos (HP:0007633)	2.07020521
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01879527
64	Chorioretinal atrophy (HP:0000533)	1.99018227
65	Tinnitus (HP:0000360)	1.97892740
66	Progressive inability to walk (HP:0002505)	1.95709950
67	Menstrual irregularities (HP:0000858)	1.92378381
68	Atonic seizures (HP:0010819)	1.91223946
69	Conjunctival hamartoma (HP:0100780)	1.91048697
70	Bone cyst (HP:0012062)	1.90196204
71	Congenital hepatic fibrosis (HP:0002612)	1.89150318
72	Petechiae (HP:0000967)	1.86542579
73	Visual hallucinations (HP:0002367)	1.86267548
74	Severe muscular hypotonia (HP:0006829)	1.85292013
75	Abnormal ciliary motility (HP:0012262)	1.85007450
76	Decreased circulating renin level (HP:0003351)	1.83851734
77	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83846637
78	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.82173990
79	Progressive cerebellar ataxia (HP:0002073)	1.80932269
80	Septo-optic dysplasia (HP:0100842)	1.77647071
81	Abnormality of cells of the erythroid lineage (HP:0012130)	1.77194643
82	Polyuria (HP:0000103)	1.76417706
83	Abnormality of incisor morphology (HP:0011063)	1.76295684
84	Meningioma (HP:0002858)	1.75562227
85	Acanthocytosis (HP:0001927)	1.74343000
86	Agitation (HP:0000713)	1.72909552
87	Impulsivity (HP:0100710)	1.72630352
88	Hypoplastic labia majora (HP:0000059)	1.72550432
89	Reticulocytopenia (HP:0001896)	1.67836186
90	Hypophosphatemic rickets (HP:0004912)	1.67773338
91	Protruding tongue (HP:0010808)	1.67675194
92	Hemiparesis (HP:0001269)	1.67292359
93	Gonadal dysgenesis (HP:0000133)	1.66594933
94	Dry hair (HP:0011359)	1.66148563
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.65569237
96	Poikilocytosis (HP:0004447)	1.65471951
97	Partial agenesis of the corpus callosum (HP:0001338)	1.64657375
98	Potter facies (HP:0002009)	1.62634116
99	Facial shape deformation (HP:0011334)	1.62634116
100	Scotoma (HP:0000575)	1.62455293

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.47887281
2	PNCK	4.10238040
3	WNK4	4.05337443
4	ACVR1B	3.32315714
5	ADRBK2	2.79189840
6	TAOK3	2.73769160
7	ZAK	2.71575317
8	MAPKAPK3	2.61263150
9	BMPR1B	2.54461869
10	STK39	2.28146814
11	GRK1	1.95257981
12	TRPM7	1.68021447
13	WEE1	1.63251603
14	MAP3K4	1.61196224
15	NUAK1	1.57062185
16	MAPK15	1.53115860
17	ADRBK1	1.42991884
18	MST4	1.41478431
19	CAMKK2	1.38815702
20	PTK2B	1.37233017
21	BMX	1.35192975
22	TNIK	1.34204066
23	TGFBR1	1.33953129
24	MAP3K14	1.30797560
25	TEC	1.30237525
26	MAP3K7	1.29608990
27	IKBKB	1.22857644
28	NME1	1.21433511
29	DAPK2	1.20734664
30	BRSK2	1.17486475
31	TLK1	1.17405769
32	BTK	1.14301250
33	MAPK13	1.11152929
34	EIF2AK1	1.09774387
35	MKNK2	1.09182231
36	CDC7	1.07775235
37	NTRK3	1.02970589
38	WNK1	1.02298635
39	ITK	1.01216511
40	PIK3CA	0.95352972
41	KIT	0.92755829
42	PKN1	0.92019915
43	STK16	0.91964679
44	MAP2K6	0.91957394
45	PRKCQ	0.91219823
46	MYLK	0.89211739
47	PRKCG	0.89099575
48	RIPK4	0.89076792
49	MAP2K3	0.86797808
50	SYK	0.85597399
51	PLK2	0.85426913
52	OXSR1	0.83855317
53	IRAK1	0.80081338
54	TSSK6	0.79994949
55	MAP3K13	0.78916027
56	MUSK	0.77499614
57	WNK3	0.76700691
58	MAP2K1	0.75160394
59	PAK3	0.72714524
60	BUB1	0.72226695
61	PHKG1	0.72103376
62	PHKG2	0.72103376
63	GRK6	0.72038720
64	MATK	0.70718983
65	TXK	0.70674599
66	IRAK4	0.69359684
67	MAP4K2	0.67888548
68	PIK3CG	0.66102848
69	VRK1	0.65899139
70	RPS6KB2	0.65097561
71	AKT3	0.63357079
72	EEF2K	0.62282206
73	ERBB2	0.61899827
74	INSRR	0.59401252
75	PRKCE	0.57610491
76	CSF1R	0.56343270
77	LYN	0.54396943
78	MAPKAPK5	0.52300936
79	PLK3	0.50437154
80	PRKAA2	0.49602545
81	ILK	0.49142145
82	EIF2AK3	0.48151721
83	CDK3	0.45751276
84	CSNK1G2	0.42700164
85	CHUK	0.40146677
86	MAPK12	0.38118613
87	STK3	0.37683359
88	TAF1	0.34991284
89	MKNK1	0.34496623
90	PASK	0.33778076
91	PRKCI	0.33417790
92	MAP2K4	0.33009817
93	PRKACG	0.32001908
94	RPS6KA5	0.31799415
95	CHEK2	0.30317902
96	PRKCD	0.27744139
97	PRKG1	0.27444944
98	PRKACA	0.27426642
99	CSNK1D	0.26998858
100	LCK	0.26298868

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.72724918
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.01749267
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.81847182
4	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.69934141
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.66518019
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.62322596
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.57551192
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.33110210
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.25881639
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.91428562
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84318101
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.75839156
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.73821262
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.65068359
15	Platelet activation_Homo sapiens_hsa04611	1.63674296
16	Homologous recombination_Homo sapiens_hsa03440	1.62017073
17	Ribosome_Homo sapiens_hsa03010	1.60941527
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.47670908
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.43036377
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.43005321
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.37987198
22	Mineral absorption_Homo sapiens_hsa04978	1.37612434
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33794433
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.31729251
25	Olfactory transduction_Homo sapiens_hsa04740	1.30468760
26	Protein export_Homo sapiens_hsa03060	1.28228413
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26970563
28	Asthma_Homo sapiens_hsa05310	1.14660973
29	Nicotine addiction_Homo sapiens_hsa05033	1.12950704
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11624301
31	Serotonergic synapse_Homo sapiens_hsa04726	1.10862536
32	One carbon pool by folate_Homo sapiens_hsa00670	1.10549450
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.08807993
34	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.06641118
35	Retinol metabolism_Homo sapiens_hsa00830	1.06463398
36	Butanoate metabolism_Homo sapiens_hsa00650	1.05652677
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.04394866
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03286257
39	Morphine addiction_Homo sapiens_hsa05032	1.02242691
40	Parkinsons disease_Homo sapiens_hsa05012	1.00639846
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.00614355
42	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.99124468
43	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.98168879
44	Mismatch repair_Homo sapiens_hsa03430	0.97999254
45	Sulfur metabolism_Homo sapiens_hsa00920	0.94440689
46	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.92420811
47	Peroxisome_Homo sapiens_hsa04146	0.89437288
48	Allograft rejection_Homo sapiens_hsa05330	0.89176965
49	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.87381515
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86806224
51	ABC transporters_Homo sapiens_hsa02010	0.86355604
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86046429
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.84813044
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.84575355
55	GABAergic synapse_Homo sapiens_hsa04727	0.83654745
56	Taste transduction_Homo sapiens_hsa04742	0.80999204
57	Regulation of autophagy_Homo sapiens_hsa04140	0.79531653
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78772914
59	Circadian entrainment_Homo sapiens_hsa04713	0.78194343
60	Caffeine metabolism_Homo sapiens_hsa00232	0.77067076
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.74550817
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.73506979
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73169534
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71553118
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70813573
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69146153
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68908653
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68033446
69	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.64221310
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64037901
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.63356743
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.63231735
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.62666473
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61622172
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59546501
76	Huntingtons disease_Homo sapiens_hsa05016	0.59053713
77	Histidine metabolism_Homo sapiens_hsa00340	0.58571592
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57844444
79	Chemokine signaling pathway_Homo sapiens_hsa04062	0.56475617
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55097678
81	Purine metabolism_Homo sapiens_hsa00230	0.52096229
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52068116
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51765489
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50777319
85	Alcoholism_Homo sapiens_hsa05034	0.49955070
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.49347768
87	Antigen processing and presentation_Homo sapiens_hsa04612	0.44618249
88	Cholinergic synapse_Homo sapiens_hsa04725	0.44591598
89	Malaria_Homo sapiens_hsa05144	0.41335701
90	RNA polymerase_Homo sapiens_hsa03020	0.41310373
91	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40983692
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40408175
93	Renin-angiotensin system_Homo sapiens_hsa04614	0.40064046
94	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.37072832
95	Salivary secretion_Homo sapiens_hsa04970	0.34745263
96	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33793259
97	TNF signaling pathway_Homo sapiens_hsa04668	0.33621004
98	Insulin secretion_Homo sapiens_hsa04911	0.32747846
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.32292244
100	Lysosome_Homo sapiens_hsa04142	0.32138789

FAM197Y6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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