ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	signal peptide processing (GO:0006465)	5.41641850
2	mesoderm development (GO:0007498)	5.41316840
3	mesenchyme development (GO:0060485)	5.00506158
4	oxygen transport (GO:0015671)	4.45520129
5	fucose catabolic process (GO:0019317)	4.31498178
6	L-fucose metabolic process (GO:0042354)	4.31498178
7	L-fucose catabolic process (GO:0042355)	4.31498178
8	sex differentiation (GO:0007548)	4.01404608
9	gonadal mesoderm development (GO:0007506)	37.2871668
10	autophagic vacuole fusion (GO:0000046)	3.97550831
11	tryptophan catabolic process (GO:0006569)	3.81251277
12	indole-containing compound catabolic process (GO:0042436)	3.81251277
13	indolalkylamine catabolic process (GO:0046218)	3.81251277
14	behavioral response to nicotine (GO:0035095)	3.73587752
15	central nervous system myelination (GO:0022010)	3.67779783
16	axon ensheathment in central nervous system (GO:0032291)	3.67779783
17	kynurenine metabolic process (GO:0070189)	3.67725139
18	gas transport (GO:0015669)	3.59287160
19	regulation of hippo signaling (GO:0035330)	3.49968363
20	indolalkylamine metabolic process (GO:0006586)	3.49665219
21	amine catabolic process (GO:0009310)	3.47702303
22	cellular biogenic amine catabolic process (GO:0042402)	3.47702303
23	tryptophan metabolic process (GO:0006568)	3.43015673
24	regulation of gene silencing by RNA (GO:0060966)	3.41272206
25	regulation of posttranscriptional gene silencing (GO:0060147)	3.41272206
26	regulation of gene silencing by miRNA (GO:0060964)	3.41272206
27	nucleosome assembly (GO:0006334)	3.38799837
28	N-acetylneuraminate metabolic process (GO:0006054)	3.35423668
29	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.28421936
30	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.28421936
31	regulation of cilium movement (GO:0003352)	3.14612764
32	multicellular organism reproduction (GO:0032504)	3.10030522
33	photoreceptor cell maintenance (GO:0045494)	3.09223388
34	protein-DNA complex assembly (GO:0065004)	3.03725514
35	fatty acid elongation (GO:0030497)	2.96377255
36	response to misfolded protein (GO:0051788)	2.93835455
37	neutrophil activation involved in immune response (GO:0002283)	2.92922489
38	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.86252991
39	endosome to pigment granule transport (GO:0043485)	2.77979506
40	endosome to melanosome transport (GO:0035646)	2.77979506
41	indole-containing compound metabolic process (GO:0042430)	2.77295866
42	protein K48-linked deubiquitination (GO:0071108)	2.76891288
43	organelle membrane fusion (GO:0090174)	2.74483205
44	cullin deneddylation (GO:0010388)	2.66481663
45	maturation of 5.8S rRNA (GO:0000460)	2.63776409
46	negative regulation of protein localization to cell surface (GO:2000009)	2.63435440
47	sulfation (GO:0051923)	2.62859332
48	nucleosome organization (GO:0034728)	2.62763374
49	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.62008625
50	cytokine biosynthetic process (GO:0042089)	2.61103867
51	negative regulation of astrocyte differentiation (GO:0048712)	2.59671586
52	protein deneddylation (GO:0000338)	2.59269412
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.58482306
54	negative regulation of mast cell activation (GO:0033004)	2.56637968
55	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.55277714
56	cellular response to cadmium ion (GO:0071276)	2.55206390
57	cellular response to zinc ion (GO:0071294)	2.54726278
58	cellular ketone body metabolic process (GO:0046950)	2.53705535
59	opioid receptor signaling pathway (GO:0038003)	2.50802326
60	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.49620226
61	neural tube formation (GO:0001841)	2.47986837
62	intracellular pH reduction (GO:0051452)	2.44178673
63	regulation of penile erection (GO:0060405)	2.43231913
64	negative regulation of heart rate (GO:0010459)	2.43205323
65	protein-DNA complex subunit organization (GO:0071824)	2.43017028
66	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.41010815
67	rhodopsin mediated signaling pathway (GO:0016056)	2.40452408
68	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.39278462
69	lysine catabolic process (GO:0006554)	2.37625415
70	lysine metabolic process (GO:0006553)	2.37625415
71	regulation of guanylate cyclase activity (GO:0031282)	2.37267376
72	regulation of microtubule-based movement (GO:0060632)	2.33647109
73	gamma-aminobutyric acid transport (GO:0015812)	2.31248398
74	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.30732786
75	positive regulation of guanylate cyclase activity (GO:0031284)	2.30191136
76	aromatic amino acid family catabolic process (GO:0009074)	2.27157960
77	protein K63-linked deubiquitination (GO:0070536)	2.27129954
78	coenzyme catabolic process (GO:0009109)	2.24181745
79	preassembly of GPI anchor in ER membrane (GO:0016254)	2.22387020
80	histone H3-K9 methylation (GO:0051567)	2.21072127
81	tonic smooth muscle contraction (GO:0014820)	2.20860431
82	cilium or flagellum-dependent cell motility (GO:0001539)	2.20409700
83	protein K11-linked deubiquitination (GO:0035871)	2.20352794
84	histone-serine phosphorylation (GO:0035404)	2.20308396
85	primary amino compound metabolic process (GO:1901160)	2.19873763
86	ketone body metabolic process (GO:1902224)	2.19760470
87	cytoplasmic mRNA processing body assembly (GO:0033962)	2.19213270
88	DNA deamination (GO:0045006)	2.18978289
89	negative regulation of appetite (GO:0032099)	2.18910983
90	negative regulation of response to food (GO:0032096)	2.18910983
91	alanine transport (GO:0032328)	2.18370116
92	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.17908819
93	cytokine metabolic process (GO:0042107)	2.15268573
94	positive regulation of mRNA 3-end processing (GO:0031442)	2.14361338
95	erythrocyte maturation (GO:0043249)	2.12650922
96	artery smooth muscle contraction (GO:0014824)	2.12590327
97	protein import into peroxisome matrix (GO:0016558)	2.12040158
98	male meiosis (GO:0007140)	2.08911119
99	rRNA catabolic process (GO:0016075)	2.08626784
100	replication fork processing (GO:0031297)	2.08290823

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.21916932
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39370211
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.25529622
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.17519303
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.91624349
6	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.28580717
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26829354
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15953275
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06532051
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.01556359
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.01216645
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.96421864
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92201029
14	DROSHA_22980978_ChIP-Seq_HELA_Human	1.87097518
15	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.86677291
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.80854610
17	FUS_26573619_Chip-Seq_HEK293_Human	1.76346244
18	EWS_26573619_Chip-Seq_HEK293_Human	1.75316347
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75126888
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74883825
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72757313
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71379312
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70282157
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69535707
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68690668
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66815188
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.65611491
28	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.61073993
29	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.60086987
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57954441
31	STAT3_23295773_ChIP-Seq_U87_Human	1.56328482
32	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.53336192
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53246194
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53246194
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52564226
36	TP53_16413492_ChIP-PET_HCT116_Human	1.48993879
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48582316
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48582316
39	TCF4_23295773_ChIP-Seq_U87_Human	1.48470475
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47949338
41	P300_19829295_ChIP-Seq_ESCs_Human	1.47278720
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46002680
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45989061
44	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.43029583
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.38862459
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37674437
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.36452811
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35683636
49	SCL_19346495_ChIP-Seq_HPC-7_Human	1.35312572
50	AR_25329375_ChIP-Seq_VCAP_Human	1.33790784
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33726794
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.31197588
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30688860
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30688860
55	AR_20517297_ChIP-Seq_VCAP_Human	1.30529289
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28190706
57	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.25057165
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24847959
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.24248399
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24248399
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23997816
62	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.21895922
63	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21819160
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21509385
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21374400
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20442451
67	TAF15_26573619_Chip-Seq_HEK293_Human	1.18010325
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17847037
69	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17433751
70	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.16916245
71	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16786212
72	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15543838
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14723269
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12651725
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11533038
76	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10457401
77	RXR_22108803_ChIP-Seq_LS180_Human	1.10167774
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08771660
79	GATA3_26560356_Chip-Seq_TH2_Human	1.07974244
80	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.07816799
81	JUN_21703547_ChIP-Seq_K562_Human	1.07082662
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06571348
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.04884628
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03887996
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.02361962
86	ERA_21632823_ChIP-Seq_H3396_Human	1.01974349
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01924851
88	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00180739
89	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99382364
90	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.99015084
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98907866
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.98722210
93	GATA1_22025678_ChIP-Seq_K562_Human	0.98042696
94	AHR_22903824_ChIP-Seq_MCF-7_Human	0.97900109
95	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97292167
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96652087
97	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95792922
98	GATA1_19941826_ChIP-Seq_K562_Human	0.95759069
99	RUNX_20019798_ChIP-Seq_JUKART_Human	0.95683897
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95668654

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	7.14003967
2	MP0004043_abnormal_pH_regulation	2.83211261
3	MP0005551_abnormal_eye_electrophysiolog	2.46833290
4	MP0001984_abnormal_olfaction	2.43402085
5	MP0008995_early_reproductive_senescence	2.34357195
6	MP0003195_calcinosis	2.32444039
7	MP0000383_abnormal_hair_follicle	2.32277488
8	MP0004147_increased_porphyrin_level	2.24138624
9	MP0005253_abnormal_eye_physiology	2.13560999
10	MP0005171_absent_coat_pigmentation	2.07474921
11	MP0005410_abnormal_fertilization	2.03009926
12	MP0009046_muscle_twitch	1.94927680
13	MP0001485_abnormal_pinna_reflex	1.87588858
14	MP0005174_abnormal_tail_pigmentation	1.83391045
15	MP0004142_abnormal_muscle_tone	1.82790699
16	MP0003011_delayed_dark_adaptation	1.79891529
17	MP0000427_abnormal_hair_cycle	1.79139334
18	MP0008872_abnormal_physiological_respon	1.76836223
19	MP0008877_abnormal_DNA_methylation	1.75390562
20	MP0001968_abnormal_touch/_nociception	1.74272791
21	MP0002638_abnormal_pupillary_reflex	1.73829869
22	MP0002653_abnormal_ependyma_morphology	1.70790385
23	MP0005377_hearing/vestibular/ear_phenot	1.62553148
24	MP0003878_abnormal_ear_physiology	1.62553148
25	MP0002736_abnormal_nociception_after	1.57725840
26	MP0003646_muscle_fatigue	1.55976237
27	MP0001501_abnormal_sleep_pattern	1.50453216
28	MP0009745_abnormal_behavioral_response	1.47848385
29	MP0002735_abnormal_chemical_nociception	1.45365974
30	MP0006072_abnormal_retinal_apoptosis	1.43484391
31	MP0000230_abnormal_systemic_arterial	1.36077514
32	MP0000372_irregular_coat_pigmentation	1.35684157
33	MP0003718_maternal_effect	1.34511171
34	MP0005464_abnormal_platelet_physiology	1.34316294
35	MP0008875_abnormal_xenobiotic_pharmacok	1.34115315
36	MP0000569_abnormal_digit_pigmentation	1.33373865
37	MP0002095_abnormal_skin_pigmentation	1.31448551
38	MP0003656_abnormal_erythrocyte_physiolo	1.30902100
39	MP0000647_abnormal_sebaceous_gland	1.30155140
40	MP0009764_decreased_sensitivity_to	1.27817459
41	MP0010678_abnormal_skin_adnexa	1.25202081
42	MP0003303_peritoneal_inflammation	1.24980221
43	MP0004215_abnormal_myocardial_fiber	1.23852977
44	MP0008004_abnormal_stomach_pH	1.23482419
45	MP0010386_abnormal_urinary_bladder	1.21064445
46	MP0004130_abnormal_muscle_cell	1.20908020
47	MP0001986_abnormal_taste_sensitivity	1.18388977
48	MP0002272_abnormal_nervous_system	1.12836533
49	MP0001970_abnormal_pain_threshold	1.08492178
50	MP0004133_heterotaxia	1.07771689
51	MP0008058_abnormal_DNA_repair	1.05099225
52	MP0002064_seizures	1.03150524
53	MP0005645_abnormal_hypothalamus_physiol	1.00562579
54	MP0002067_abnormal_sensory_capabilities	1.00285211
55	MP0002229_neurodegeneration	0.99949214
56	MP0005646_abnormal_pituitary_gland	0.99480439
57	MP0003698_abnormal_male_reproductive	0.99044811
58	MP0006276_abnormal_autonomic_nervous	0.97947980
59	MP0002928_abnormal_bile_duct	0.95545402
60	MP0001905_abnormal_dopamine_level	0.94998632
61	MP0002148_abnormal_hypersensitivity_rea	0.94258541
62	MP0001664_abnormal_digestion	0.94155427
63	MP0003252_abnormal_bile_duct	0.93862986
64	MP0008569_lethality_at_weaning	0.93045100
65	MP0002938_white_spotting	0.92583929
66	MP0005365_abnormal_bile_salt	0.90941038
67	MP0000631_abnormal_neuroendocrine_gland	0.90187604
68	MP0001663_abnormal_digestive_system	0.88733783
69	MP0000566_synostosis	0.88630010
70	MP0008775_abnormal_heart_ventricle	0.86126613
71	MP0001486_abnormal_startle_reflex	0.85749586
72	MP0003119_abnormal_digestive_system	0.84768627
73	MP0010329_abnormal_lipoprotein_level	0.83869004
74	MP0005275_abnormal_skin_tensile	0.83251441
75	MP0004885_abnormal_endolymph	0.81623053
76	MP0002733_abnormal_thermal_nociception	0.81225407
77	MP0003632_abnormal_nervous_system	0.80376495
78	MP0001929_abnormal_gametogenesis	0.79716367
79	MP0002572_abnormal_emotion/affect_behav	0.79279626
80	MP0000579_abnormal_nail_morphology	0.78683465
81	MP0001502_abnormal_circadian_rhythm	0.78560730
82	MP0005595_abnormal_vascular_smooth	0.78529276
83	MP0005636_abnormal_mineral_homeostasis	0.77178144
84	MP0005195_abnormal_posterior_eye	0.76537773
85	MP0001661_extended_life_span	0.76299729
86	MP0008961_abnormal_basal_metabolism	0.76172834
87	MP0003693_abnormal_embryo_hatching	0.75975904
88	MP0005332_abnormal_amino_acid	0.75827759
89	MP0002693_abnormal_pancreas_physiology	0.74283752
90	MP0005085_abnormal_gallbladder_physiolo	0.74249857
91	MP0001756_abnormal_urination	0.73989562
92	MP0001800_abnormal_humoral_immune	0.73331422
93	MP0003638_abnormal_response/metabolism_	0.69541837
94	MP0005395_other_phenotype	0.69446880
95	MP0003959_abnormal_lean_body	0.67023096
96	MP0000470_abnormal_stomach_morphology	0.66884482
97	MP0009053_abnormal_anal_canal	0.65402881
98	MP0000538_abnormal_urinary_bladder	0.65078736
99	MP0002277_abnormal_respiratory_mucosa	0.64682341
100	MP0005671_abnormal_response_to	0.64614578

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.64207913
2	Abnormal hemoglobin (HP:0011902)	4.51104604
3	Congenital, generalized hypertrichosis (HP:0004540)	4.24618838
4	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	4.16401107
5	Pancreatic cysts (HP:0001737)	4.02442918
6	Large for gestational age (HP:0001520)	4.00234700
7	Pancreatic fibrosis (HP:0100732)	3.94711903
8	Increased cerebral lipofuscin (HP:0011813)	3.88798794
9	True hermaphroditism (HP:0010459)	3.67066567
10	Congenital stationary night blindness (HP:0007642)	3.59795887
11	Chronic hepatic failure (HP:0100626)	3.55419165
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.36558681
13	Abnormality of alanine metabolism (HP:0010916)	3.36558681
14	Hyperalaninemia (HP:0003348)	3.36558681
15	Cystic liver disease (HP:0006706)	3.32949377
16	Clumsiness (HP:0002312)	3.14742847
17	Abnormality of midbrain morphology (HP:0002418)	3.14112412
18	Molar tooth sign on MRI (HP:0002419)	3.14112412
19	Decreased circulating renin level (HP:0003351)	3.08485285
20	Type II lissencephaly (HP:0007260)	3.00201798
21	Abnormality of the pons (HP:0007361)	2.96629980
22	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.88680298
23	Duplicated collecting system (HP:0000081)	2.82736893
24	Abnormal number of erythroid precursors (HP:0012131)	2.82133200
25	Hypoplasia of the pons (HP:0012110)	2.77206358
26	Conical tooth (HP:0000698)	2.76584295
27	Birth length less than 3rd percentile (HP:0003561)	2.75224818
28	Nephronophthisis (HP:0000090)	2.73567595
29	Furrowed tongue (HP:0000221)	2.73292091
30	Abnormal biliary tract physiology (HP:0012439)	2.61176643
31	Bile duct proliferation (HP:0001408)	2.61176643
32	Concave nail (HP:0001598)	2.61156108
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58859478
34	Progressive cerebellar ataxia (HP:0002073)	2.55472034
35	Cerebellar dysplasia (HP:0007033)	2.54443975
36	Abnormality of the renal collecting system (HP:0004742)	2.52709937
37	Genetic anticipation (HP:0003743)	2.38921392
38	Abnormality of the renal cortex (HP:0011035)	2.36746993
39	Inability to walk (HP:0002540)	2.36020215
40	Bilateral microphthalmos (HP:0007633)	2.35265083
41	Abnormality of the renal medulla (HP:0100957)	2.34268792
42	Sclerocornea (HP:0000647)	2.32290418
43	Abnormality of binocular vision (HP:0011514)	2.30120724
44	Diplopia (HP:0000651)	2.30120724
45	Spastic tetraparesis (HP:0001285)	2.28827076
46	Hemiparesis (HP:0001269)	2.28764128
47	Abolished electroretinogram (ERG) (HP:0000550)	2.27855709
48	Chorioretinal atrophy (HP:0000533)	2.26476817
49	Breast hypoplasia (HP:0003187)	2.26367401
50	Polydipsia (HP:0001959)	2.24504257
51	Abnormal drinking behavior (HP:0030082)	2.24504257
52	Abnormality of cells of the erythroid lineage (HP:0012130)	2.20167855
53	Hyperlipoproteinemia (HP:0010980)	2.18871284
54	Progressive inability to walk (HP:0002505)	2.17297132
55	Prolonged bleeding time (HP:0003010)	2.16376816
56	Partial agenesis of the corpus callosum (HP:0001338)	2.15000003
57	Abnormal hair laboratory examination (HP:0003328)	2.12783220
58	Hypoplastic iliac wings (HP:0002866)	2.11915713
59	Abnormal auditory evoked potentials (HP:0006958)	2.10740813
60	Renal cortical cysts (HP:0000803)	2.10437221
61	Stomach cancer (HP:0012126)	2.09195718
62	Severe muscular hypotonia (HP:0006829)	2.08782557
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04254194
64	Anencephaly (HP:0002323)	2.00698561
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.99520495
66	Abnormal protein N-linked glycosylation (HP:0012347)	1.99520495
67	Abnormal protein glycosylation (HP:0012346)	1.99520495
68	Abnormal glycosylation (HP:0012345)	1.99520495
69	Congenital hepatic fibrosis (HP:0002612)	1.96637772
70	Protruding tongue (HP:0010808)	1.94119137
71	Hyperventilation (HP:0002883)	1.94056991
72	Absent/shortened dynein arms (HP:0200106)	1.92910874
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92910874
74	Lissencephaly (HP:0001339)	1.91226410
75	Hyperglycinuria (HP:0003108)	1.90554193
76	Ulnar claw (HP:0001178)	1.90351768
77	Reticulocytopenia (HP:0001896)	1.89833969
78	Female pseudohermaphroditism (HP:0010458)	1.89721999
79	Conjunctival hamartoma (HP:0100780)	1.89320268
80	Abnormality of incisor morphology (HP:0011063)	1.87468433
81	Poor head control (HP:0002421)	1.87327026
82	Hypoplastic labia majora (HP:0000059)	1.83860941
83	Dry hair (HP:0011359)	1.82490535
84	Follicular hyperkeratosis (HP:0007502)	1.82285992
85	Depressed nasal tip (HP:0000437)	1.82284000
86	Thyroid-stimulating hormone excess (HP:0002925)	1.80452436
87	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80436104
88	Abnormal respiratory epithelium morphology (HP:0012253)	1.80436104
89	Abnormality of macular pigmentation (HP:0008002)	1.78334393
90	Bone cyst (HP:0012062)	1.77294519
91	Brushfield spots (HP:0001088)	1.75200736
92	Polyuria (HP:0000103)	1.73039631
93	Patellar aplasia (HP:0006443)	1.71133337
94	Male pseudohermaphroditism (HP:0000037)	1.71041028
95	Progressive visual loss (HP:0000529)	1.70806213
96	Occipital encephalocele (HP:0002085)	1.69424640
97	Abnormality of B cell number (HP:0010975)	1.62916492
98	Pendular nystagmus (HP:0012043)	1.62817341
99	Menorrhagia (HP:0000132)	1.62335483
100	Abnormality of renin-angiotensin system (HP:0000847)	1.62044502

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.60698328
2	PDK2	5.24033604
3	BMPR1B	3.88280923
4	ACVR1B	3.16532083
5	ADRBK2	3.01226195
6	WNK4	2.95526248
7	MAPKAPK3	2.67117868
8	TGFBR1	1.99754756
9	PNCK	1.98629651
10	DAPK2	1.76859213
11	EEF2K	1.72465919
12	CDK8	1.67811487
13	TAOK3	1.64976134
14	GRK1	1.58433457
15	ZAK	1.53287512
16	CDC7	1.52388287
17	ADRBK1	1.46953871
18	NME1	1.43715405
19	STK39	1.40111721
20	TRPM7	1.37694031
21	MAP3K4	1.36254424
22	IKBKB	1.29362276
23	MAPK12	1.27081731
24	TLK1	1.23580614
25	MAP3K7	1.23457510
26	ITK	1.21593195
27	MAPK15	1.17749356
28	BRSK2	1.16397000
29	PTK2B	1.16123347
30	MKNK2	1.15256988
31	CDK3	1.14653736
32	MAP3K13	1.11768008
33	RPS6KB2	1.06773500
34	BMX	1.05536083
35	NTRK3	1.03430918
36	NUAK1	1.02540359
37	MAPK13	1.02212640
38	WEE1	1.01411127
39	MAPK7	1.00117265
40	MST4	0.99365317
41	CAMKK2	0.97975662
42	NEK6	0.97879281
43	TEC	0.95154983
44	IRAK1	0.91695650
45	OXSR1	0.91142920
46	MAP2K6	0.90280094
47	PRKCG	0.86963723
48	PRKCQ	0.86411443
49	INSRR	0.83232994
50	PIK3CA	0.82909564
51	MAP2K1	0.82357515
52	PKN1	0.77538939
53	BCKDK	0.75310225
54	MUSK	0.75202551
55	NTRK2	0.73204335
56	PHKG2	0.72469120
57	PHKG1	0.72469120
58	PRKAA2	0.71790257
59	BTK	0.71761915
60	AKT3	0.69155971
61	TNIK	0.69038139
62	MAP3K14	0.67511785
63	TXK	0.65465673
64	EIF2AK3	0.65257182
65	KIT	0.65033053
66	SYK	0.64443528
67	MAPKAPK5	0.61564817
68	PRKCE	0.61055981
69	BUB1	0.60889412
70	CSF1R	0.60171716
71	PIK3CG	0.59405043
72	EIF2AK1	0.59360244
73	WNK3	0.58663292
74	CHUK	0.58137910
75	PDPK1	0.52206424
76	MAPK11	0.51079713
77	PDK1	0.50211049
78	RIPK4	0.49232972
79	GRK6	0.47985279
80	WNK1	0.44352899
81	PRKCI	0.43112915
82	PIM1	0.41858647
83	MAP2K2	0.37667082
84	VRK2	0.37436823
85	VRK1	0.36689636
86	MAP4K1	0.36595118
87	CSNK1D	0.34844857
88	TSSK6	0.34140432
89	PRKACG	0.32762371
90	MKNK1	0.31879544
91	ERBB2	0.31589774
92	RPS6KA5	0.31351757
93	CHEK2	0.31145688
94	RPS6KA6	0.31015714
95	PLK2	0.30875748
96	MAP4K2	0.30839510
97	AKT2	0.30547343
98	PRKACA	0.29785780
99	LYN	0.28293806
100	BRSK1	0.28227362

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.58571158
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.11613508
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.87820883
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.74363481
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.71426672
6	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.33252525
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.25747525
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.22075631
9	One carbon pool by folate_Homo sapiens_hsa00670	2.21968653
10	Olfactory transduction_Homo sapiens_hsa04740	2.11250825
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84735678
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.82927255
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81224261
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.76104363
15	Butanoate metabolism_Homo sapiens_hsa00650	1.73299820
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.71638092
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62651951
18	Homologous recombination_Homo sapiens_hsa03440	1.60294176
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.59133425
20	ABC transporters_Homo sapiens_hsa02010	1.56696390
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.55961820
22	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.45036731
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.41062661
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.39464669
25	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.39016100
26	Ribosome_Homo sapiens_hsa03010	1.36416933
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.34179365
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31802910
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29330002
30	Protein export_Homo sapiens_hsa03060	1.27200995
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23952366
32	RNA polymerase_Homo sapiens_hsa03020	1.21848437
33	Taste transduction_Homo sapiens_hsa04742	1.15461268
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15315675
35	Morphine addiction_Homo sapiens_hsa05032	1.15011111
36	Fatty acid elongation_Homo sapiens_hsa00062	1.12928546
37	Pancreatic secretion_Homo sapiens_hsa04972	1.11454301
38	Nicotine addiction_Homo sapiens_hsa05033	1.06981993
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.06794943
40	Peroxisome_Homo sapiens_hsa04146	1.05902128
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02490355
42	Allograft rejection_Homo sapiens_hsa05330	1.01949200
43	Mineral absorption_Homo sapiens_hsa04978	1.01634982
44	Fat digestion and absorption_Homo sapiens_hsa04975	1.00304290
45	Renin-angiotensin system_Homo sapiens_hsa04614	0.99361938
46	Parkinsons disease_Homo sapiens_hsa05012	0.98872439
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.96093818
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90025074
49	Calcium signaling pathway_Homo sapiens_hsa04020	0.88721511
50	Retinol metabolism_Homo sapiens_hsa00830	0.88349178
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85946876
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.85896698
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85796298
54	Purine metabolism_Homo sapiens_hsa00230	0.85144975
55	Platelet activation_Homo sapiens_hsa04611	0.83605892
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83236063
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81372195
58	Serotonergic synapse_Homo sapiens_hsa04726	0.80955690
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79025998
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73933253
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.72718303
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.71825421
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71297281
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69304438
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69171333
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68538100
67	Asthma_Homo sapiens_hsa05310	0.65789532
68	Circadian entrainment_Homo sapiens_hsa04713	0.65733390
69	GABAergic synapse_Homo sapiens_hsa04727	0.64286138
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63063187
71	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60555262
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.59046751
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57350718
74	Caffeine metabolism_Homo sapiens_hsa00232	0.55255254
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.53756863
76	Circadian rhythm_Homo sapiens_hsa04710	0.53693564
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52860877
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51768295
79	Histidine metabolism_Homo sapiens_hsa00340	0.51428557
80	Huntingtons disease_Homo sapiens_hsa05016	0.51356001
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50859228
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50416509
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.49934291
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49641834
85	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48103832
86	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47994973
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47156362
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45056146
89	Mismatch repair_Homo sapiens_hsa03430	0.44457998
90	Metabolic pathways_Homo sapiens_hsa01100	0.43154476
91	Propanoate metabolism_Homo sapiens_hsa00640	0.40489765
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.38234735
93	Insulin secretion_Homo sapiens_hsa04911	0.36447967
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33853228
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33714283
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.33023015
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32809573
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32569498
99	Bile secretion_Homo sapiens_hsa04976	0.30486006
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30348126

FAM197Y8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »