ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.14132195
2	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	4.64914060
3	regulation of meiosis I (GO:0060631)	4.63274719
4	neuron cell-cell adhesion (GO:0007158)	4.59866621
5	positive regulation of growth hormone secretion (GO:0060124)	4.46835449
6	alkaloid metabolic process (GO:0009820)	4.34019402
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.28408994
8	tachykinin receptor signaling pathway (GO:0007217)	4.21623662
9	somite rostral/caudal axis specification (GO:0032525)	4.08479245
10	centriole replication (GO:0007099)	4.03336350
11	neuron maturation (GO:0042551)	4.00459643
12	peristalsis (GO:0030432)	3.92721694
13	neural tube formation (GO:0001841)	3.89733010
14	nonmotile primary cilium assembly (GO:0035058)	3.89552628
15	regulation of dopamine secretion (GO:0014059)	3.88698531
16	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.87021722
17	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.84114761
18	rhodopsin mediated signaling pathway (GO:0016056)	3.82923285
19	signal peptide processing (GO:0006465)	3.65313818
20	sulfation (GO:0051923)	3.64446329
21	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.61700145
22	fucose catabolic process (GO:0019317)	3.61104854
23	L-fucose metabolic process (GO:0042354)	3.61104854
24	L-fucose catabolic process (GO:0042355)	3.61104854
25	sulfate transmembrane transport (GO:1902358)	3.58513223
26	sphingoid metabolic process (GO:0046519)	3.55469384
27	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.50444767
28	DNA methylation involved in gamete generation (GO:0043046)	3.48267150
29	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.44749534
30	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.43572050
31	sulfate transport (GO:0008272)	3.43569569
32	platelet dense granule organization (GO:0060155)	3.43187646
33	tyrosine metabolic process (GO:0006570)	3.41947489
34	postsynaptic membrane organization (GO:0001941)	3.40080307
35	retinal cone cell development (GO:0046549)	3.38191476
36	regulation of growth hormone secretion (GO:0060123)	3.27564730
37	head development (GO:0060322)	3.27373826
38	regulation of catecholamine metabolic process (GO:0042069)	3.22531873
39	regulation of dopamine metabolic process (GO:0042053)	3.22531873
40	lipopolysaccharide biosynthetic process (GO:0009103)	3.19221581
41	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.17082744
42	negative regulation of mast cell activation (GO:0033004)	3.15175193
43	positive regulation of gastrulation (GO:2000543)	3.14593446
44	piRNA metabolic process (GO:0034587)	3.13436634
45	phasic smooth muscle contraction (GO:0014821)	3.13431841
46	serotonin metabolic process (GO:0042428)	3.13108228
47	determination of adult lifespan (GO:0008340)	3.10501676
48	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.09074930
49	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.03538336
50	drug catabolic process (GO:0042737)	3.00338066
51	nodal signaling pathway (GO:0038092)	2.99900452
52	diol metabolic process (GO:0034311)	2.93965888
53	cellular ketone body metabolic process (GO:0046950)	2.91579295
54	kynurenine metabolic process (GO:0070189)	2.88189218
55	primitive streak formation (GO:0090009)	2.85813213
56	neuron fate specification (GO:0048665)	2.84153295
57	dopamine biosynthetic process (GO:0042416)	2.83507596
58	primary amino compound metabolic process (GO:1901160)	2.83006083
59	indolalkylamine metabolic process (GO:0006586)	2.82570829
60	oxidative demethylation (GO:0070989)	2.80185905
61	photoreceptor cell maintenance (GO:0045494)	2.77059221
62	amino-acid betaine metabolic process (GO:0006577)	2.77039013
63	spinal cord motor neuron differentiation (GO:0021522)	2.72383571
64	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.71548398
65	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.70819226
66	lysosome localization (GO:0032418)	2.70733505
67	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	2.70504299
68	visual perception (GO:0007601)	2.70179505
69	positive regulation of meiosis (GO:0045836)	2.69478380
70	regulation of interleukin-5 production (GO:0032674)	2.69277890
71	limb development (GO:0060173)	2.68765477
72	appendage development (GO:0048736)	2.68765477
73	sphingosine metabolic process (GO:0006670)	2.68748187
74	sensory perception of light stimulus (GO:0050953)	2.67712214
75	detection of light stimulus involved in sensory perception (GO:0050962)	2.66037803
76	detection of light stimulus involved in visual perception (GO:0050908)	2.66037803
77	positive regulation of heart rate (GO:0010460)	2.65257160
78	cell differentiation in spinal cord (GO:0021515)	2.64053548
79	growth hormone secretion (GO:0030252)	2.63803990
80	response to insecticide (GO:0017085)	2.63022976
81	cullin deneddylation (GO:0010388)	2.62188028
82	protein import into peroxisome matrix (GO:0016558)	2.60759595
83	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.60360043
84	regulation of uterine smooth muscle contraction (GO:0070472)	2.59864136
85	opioid receptor signaling pathway (GO:0038003)	2.58293246
86	atrial cardiac muscle cell action potential (GO:0086014)	2.58191688
87	neurotransmitter-gated ion channel clustering (GO:0072578)	2.58063438
88	telencephalon development (GO:0021537)	2.57671695
89	ketone body metabolic process (GO:1902224)	2.56493252
90	lipopolysaccharide metabolic process (GO:0008653)	2.54518286
91	protein complex biogenesis (GO:0070271)	2.54491055
92	endoderm formation (GO:0001706)	2.52346218
93	single strand break repair (GO:0000012)	2.52118923
94	cilium organization (GO:0044782)	2.51875334
95	C4-dicarboxylate transport (GO:0015740)	2.51477134
96	DNA integration (GO:0015074)	2.49958560
97	cilium assembly (GO:0042384)	2.49688694
98	centriole assembly (GO:0098534)	2.49562749
99	basic amino acid transport (GO:0015802)	2.48976512
100	gonadal mesoderm development (GO:0007506)	11.8326490

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.12180285
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.10137702
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.76865869
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.42715178
5	VDR_22108803_ChIP-Seq_LS180_Human	2.76822256
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.65952049
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61264747
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.48076991
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.45874603
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.32575463
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19789952
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.14585306
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.01091343
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91368374
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90425486
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83584275
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83032775
18	P300_19829295_ChIP-Seq_ESCs_Human	1.77674155
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72198454
20	EWS_26573619_Chip-Seq_HEK293_Human	1.65946204
21	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.65726404
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60909543
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60565075
24	STAT3_23295773_ChIP-Seq_U87_Human	1.59752695
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.57894141
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.54418941
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54192673
28	TP53_16413492_ChIP-PET_HCT116_Human	1.53902405
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53111523
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50287069
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.47830370
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45651206
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43136269
34	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.42729654
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42462911
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40411525
37	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37274846
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37060848
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35223481
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35223481
41	GATA1_22025678_ChIP-Seq_K562_Human	1.33236796
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33144334
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32636461
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32070271
45	FUS_26573619_Chip-Seq_HEK293_Human	1.31852117
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31332977
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30903532
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30498480
49	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30433706
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28688477
51	TCF4_23295773_ChIP-Seq_U87_Human	1.28341717
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27062861
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27062861
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.25113181
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24269742
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24269742
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.24012413
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.23678979
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22800830
60	AR_25329375_ChIP-Seq_VCAP_Human	1.21362953
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21139042
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20087554
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19430644
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.19204764
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19204764
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.18957233
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17690636
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16422868
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16156833
70	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14995508
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14819902
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13942618
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.13655041
74	RXR_22108803_ChIP-Seq_LS180_Human	1.12903698
75	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.11503324
76	DROSHA_22980978_ChIP-Seq_HELA_Human	1.11395189
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10982799
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08203656
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08106740
80	NCOR_22424771_ChIP-Seq_293T_Human	1.07989662
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07703848
82	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07157361
83	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06810499
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06485659
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03549852
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02430741
87	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.02373952
88	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.02283809
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02224516
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02034571
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00891008
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99003745
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98762286
94	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98468071
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97212065
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96533528
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95912586
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95837901
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94588670
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94520166

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.30764108
2	MP0005171_absent_coat_pigmentation	4.81131140
3	MP0002653_abnormal_ependyma_morphology	4.71433141
4	MP0003136_yellow_coat_color	4.30512868
5	MP0003890_abnormal_embryonic-extraembry	3.73739819
6	MP0004885_abnormal_endolymph	3.34327377
7	MP0002837_dystrophic_cardiac_calcinosis	2.87625858
8	MP0005551_abnormal_eye_electrophysiolog	2.71491916
9	MP0002938_white_spotting	2.50030416
10	MP0001501_abnormal_sleep_pattern	2.34128910
11	MP0005174_abnormal_tail_pigmentation	2.25323571
12	MP0000566_synostosis	2.17008585
13	MP0004742_abnormal_vestibular_system	2.16092572
14	MP0001485_abnormal_pinna_reflex	2.15432360
15	MP0002095_abnormal_skin_pigmentation	2.01333959
16	MP0004133_heterotaxia	1.97038489
17	MP0008875_abnormal_xenobiotic_pharmacok	1.88679030
18	MP0003195_calcinosis	1.88183113
19	MP0004147_increased_porphyrin_level	1.78627413
20	MP0002254_reproductive_system_inflammat	1.73896518
21	MP0003646_muscle_fatigue	1.73091352
22	MP0002557_abnormal_social/conspecific_i	1.50054691
23	MP0002272_abnormal_nervous_system	1.47339947
24	MP0000372_irregular_coat_pigmentation	1.44727268
25	MP0004142_abnormal_muscle_tone	1.43837601
26	MP0000427_abnormal_hair_cycle	1.41079487
27	MP0001324_abnormal_eye_pigmentation	1.40049468
28	MP0002736_abnormal_nociception_after	1.34445360
29	MP0002572_abnormal_emotion/affect_behav	1.32202565
30	MP0001529_abnormal_vocalization	1.30836460
31	MP0003283_abnormal_digestive_organ	1.29524925
32	MP0008995_early_reproductive_senescence	1.29344698
33	MP0003718_maternal_effect	1.27932173
34	MP0000026_abnormal_inner_ear	1.27534290
35	MP0008872_abnormal_physiological_respon	1.27120215
36	MP0008877_abnormal_DNA_methylation	1.26261820
37	MP0000015_abnormal_ear_pigmentation	1.24158365
38	MP0000631_abnormal_neuroendocrine_gland	1.23087605
39	MP0001293_anophthalmia	1.18974269
40	MP0003950_abnormal_plasma_membrane	1.18857091
41	MP0004381_abnormal_hair_follicle	1.18495536
42	MP0005253_abnormal_eye_physiology	1.18271547
43	MP0000383_abnormal_hair_follicle	1.17548605
44	MP0001968_abnormal_touch/_nociception	1.15959443
45	MP0002735_abnormal_chemical_nociception	1.15249799
46	MP0003879_abnormal_hair_cell	1.12946534
47	MP0002102_abnormal_ear_morphology	1.12201569
48	MP0005085_abnormal_gallbladder_physiolo	1.12175327
49	MP0004043_abnormal_pH_regulation	1.10872638
50	MP0003959_abnormal_lean_body	1.08999664
51	MP0005195_abnormal_posterior_eye	1.06415160
52	MP0002928_abnormal_bile_duct	1.04893088
53	MP0008004_abnormal_stomach_pH	1.04565157
54	MP0000647_abnormal_sebaceous_gland	1.04004650
55	MP0009745_abnormal_behavioral_response	1.02321943
56	MP0005167_abnormal_blood-brain_barrier	1.01370440
57	MP0003045_fibrosis	1.00755354
58	MP0008961_abnormal_basal_metabolism	1.00678966
59	MP0001984_abnormal_olfaction	1.00043492
60	MP0005670_abnormal_white_adipose	0.96749862
61	MP0001440_abnormal_grooming_behavior	0.96749612
62	MP0005266_abnormal_metabolism	0.96518092
63	MP0002067_abnormal_sensory_capabilities	0.95205028
64	MP0001986_abnormal_taste_sensitivity	0.95102611
65	MP0003937_abnormal_limbs/digits/tail_de	0.93856329
66	MP0000534_abnormal_ureter_morphology	0.93448253
67	MP0008775_abnormal_heart_ventricle	0.93198928
68	MP0002064_seizures	0.92507779
69	MP0001963_abnormal_hearing_physiology	0.91321530
70	MP0004924_abnormal_behavior	0.90537501
71	MP0005386_behavior/neurological_phenoty	0.90537501
72	MP0006276_abnormal_autonomic_nervous	0.86116175
73	MP0006035_abnormal_mitochondrial_morpho	0.85726560
74	MP0003806_abnormal_nucleotide_metabolis	0.83281696
75	MP0003011_delayed_dark_adaptation	0.81036336
76	MP0005084_abnormal_gallbladder_morpholo	0.80651280
77	MP0008569_lethality_at_weaning	0.77940307
78	MP0003638_abnormal_response/metabolism_	0.77478218
79	MP0002638_abnormal_pupillary_reflex	0.77234005
80	MP0003943_abnormal_hepatobiliary_system	0.77057016
81	MP0002063_abnormal_learning/memory/cond	0.76816276
82	MP0002229_neurodegeneration	0.76436599
83	MP0003315_abnormal_perineum_morphology	0.76016324
84	MP0005395_other_phenotype	0.75885489
85	MP0001486_abnormal_startle_reflex	0.75424328
86	MP0002752_abnormal_somatic_nervous	0.74734456
87	MP0002184_abnormal_innervation	0.72369162
88	MP0009046_muscle_twitch	0.72062060
89	MP0002277_abnormal_respiratory_mucosa	0.72037794
90	MP0003635_abnormal_synaptic_transmissio	0.71746480
91	MP0003698_abnormal_male_reproductive	0.71331367
92	MP0002876_abnormal_thyroid_physiology	0.71018359
93	MP0002075_abnormal_coat/hair_pigmentati	0.69556123
94	MP0001970_abnormal_pain_threshold	0.68672083
95	MP0003942_abnormal_urinary_system	0.68665369
96	MP0001905_abnormal_dopamine_level	0.68067819
97	MP0002733_abnormal_thermal_nociception	0.67851862
98	MP0009764_decreased_sensitivity_to	0.65238714
99	MP0000470_abnormal_stomach_morphology	0.62982504
100	MP0003122_maternal_imprinting	0.62957101

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.19395856
2	Pancreatic cysts (HP:0001737)	4.22003125
3	Oligodactyly (hands) (HP:0001180)	4.10928677
4	Focal motor seizures (HP:0011153)	4.07221941
5	Abnormality of the renal cortex (HP:0011035)	3.83411507
6	Nephronophthisis (HP:0000090)	3.82066292
7	Abnormality of midbrain morphology (HP:0002418)	3.77402145
8	Molar tooth sign on MRI (HP:0002419)	3.77402145
9	Abnormality of the renal medulla (HP:0100957)	3.65916206
10	Amelogenesis imperfecta (HP:0000705)	3.60452058
11	Pancreatic fibrosis (HP:0100732)	3.48768486
12	Nephrogenic diabetes insipidus (HP:0009806)	3.47360037
13	Attenuation of retinal blood vessels (HP:0007843)	3.42362172
14	True hermaphroditism (HP:0010459)	3.35273769
15	Chronic hepatic failure (HP:0100626)	3.12672166
16	Congenital sensorineural hearing impairment (HP:0008527)	3.09373853
17	Birth length less than 3rd percentile (HP:0003561)	3.07155861
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.99785594
19	Abnormality of alanine metabolism (HP:0010916)	2.99785594
20	Hyperalaninemia (HP:0003348)	2.99785594
21	Abolished electroretinogram (ERG) (HP:0000550)	2.96235431
22	3-Methylglutaconic aciduria (HP:0003535)	2.85504325
23	Medial flaring of the eyebrow (HP:0010747)	2.85108566
24	Rectal prolapse (HP:0002035)	2.83944524
25	Abnormality of incisor morphology (HP:0011063)	2.69762249
26	Gait imbalance (HP:0002141)	2.67757236
27	Furrowed tongue (HP:0000221)	2.67267037
28	Protruding tongue (HP:0010808)	2.66440343
29	Clumsiness (HP:0002312)	2.63542080
30	Bony spicule pigmentary retinopathy (HP:0007737)	2.62929069
31	Conjugated hyperbilirubinemia (HP:0002908)	2.61747447
32	Congenital primary aphakia (HP:0007707)	2.60339497
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.56530509
34	Concave nail (HP:0001598)	2.53252555
35	Oligodactyly (HP:0012165)	2.50931168
36	Polyuria (HP:0000103)	2.49513794
37	Hypoplasia of the pons (HP:0012110)	2.49453956
38	Morphological abnormality of the inner ear (HP:0011390)	2.41180965
39	Tubular atrophy (HP:0000092)	2.34729727
40	Hyperventilation (HP:0002883)	2.34168613
41	Genital tract atresia (HP:0001827)	2.33440580
42	Limb dystonia (HP:0002451)	2.31255530
43	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.29972641
44	Inability to walk (HP:0002540)	2.26536105
45	Abnormality of macular pigmentation (HP:0008002)	2.24762429
46	Renal cortical cysts (HP:0000803)	2.23465541
47	Hip dysplasia (HP:0001385)	2.23052513
48	Cystic liver disease (HP:0006706)	2.21043658
49	Abnormality of the pons (HP:0007361)	2.20859063
50	Hypoplastic labia majora (HP:0000059)	2.20406277
51	Vaginal atresia (HP:0000148)	2.20188100
52	Chorioretinal atrophy (HP:0000533)	2.20047297
53	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.19068345
54	Abnormal biliary tract physiology (HP:0012439)	2.17231279
55	Bile duct proliferation (HP:0001408)	2.17231279
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17006259
57	Abnormal number of erythroid precursors (HP:0012131)	2.17002386
58	Congenital, generalized hypertrichosis (HP:0004540)	2.16438924
59	Hypomagnesemia (HP:0002917)	2.15282613
60	Anophthalmia (HP:0000528)	2.14928739
61	Sclerocornea (HP:0000647)	2.11662104
62	Alkalosis (HP:0001948)	2.09456124
63	Patellar aplasia (HP:0006443)	2.08478580
64	Progressive inability to walk (HP:0002505)	2.08161621
65	Bell-shaped thorax (HP:0001591)	2.02963045
66	Optic disc pallor (HP:0000543)	2.02919369
67	Fibular hypoplasia (HP:0003038)	2.01847270
68	Abnormality of the 4th metacarpal (HP:0010012)	2.01467113
69	Metabolic alkalosis (HP:0200114)	2.01458486
70	Pheochromocytoma (HP:0002666)	2.01442210
71	Abnormal urine output (HP:0012590)	1.98770545
72	Small hand (HP:0200055)	1.98489745
73	Abnormality of the right ventricle (HP:0001707)	1.98146585
74	Abnormality of the labia majora (HP:0012881)	1.97891325
75	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.95878683
76	Hypoplasia of the fovea (HP:0007750)	1.95878683
77	Fair hair (HP:0002286)	1.92998090
78	Recurrent corneal erosions (HP:0000495)	1.92971530
79	Abnormality of the labia minora (HP:0012880)	1.92709911
80	Polydipsia (HP:0001959)	1.92449505
81	Abnormal drinking behavior (HP:0030082)	1.92449505
82	Labial hypoplasia (HP:0000066)	1.92077454
83	Poor coordination (HP:0002370)	1.91353164
84	Hypokalemic alkalosis (HP:0001949)	1.91041865
85	Ketoacidosis (HP:0001993)	1.89629008
86	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87147933
87	Keratoconus (HP:0000563)	1.86811576
88	Increased corneal curvature (HP:0100692)	1.86811576
89	Hyperglycinuria (HP:0003108)	1.86783372
90	Anencephaly (HP:0002323)	1.85842153
91	Hypoplastic ischia (HP:0003175)	1.85524809
92	Tubulointerstitial fibrosis (HP:0005576)	1.84981611
93	Hypoplastic iliac wings (HP:0002866)	1.84582709
94	Abnormal ciliary motility (HP:0012262)	1.83802977
95	Congenital hepatic fibrosis (HP:0002612)	1.83577318
96	Colon cancer (HP:0003003)	1.82947222
97	Abnormality of cells of the erythroid lineage (HP:0012130)	1.82499294
98	Renal salt wasting (HP:0000127)	1.80583410
99	Partial agenesis of the corpus callosum (HP:0001338)	1.80540237
100	Retinitis pigmentosa (HP:0000510)	1.79637422

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	5.69130806
2	BMPR1B	4.01078266
3	STK38L	3.68538464
4	ACVR1B	3.65766284
5	FRK	3.55275813
6	ADRBK2	3.06865725
7	NUAK1	2.69932412
8	WNK3	2.67695397
9	MAP4K2	2.36366271
10	MKNK2	2.02531433
11	TGFBR1	1.92369548
12	ADRBK1	1.90449189
13	ZAK	1.83728739
14	GRK1	1.83048008
15	CDK8	1.78098397
16	NEK1	1.69370762
17	CDK3	1.68104343
18	MAPK13	1.66802453
19	CAMKK2	1.59801837
20	INSRR	1.55387551
21	LATS2	1.51682416
22	MKNK1	1.51360967
23	PIK3CG	1.40695614
24	STK3	1.40376042
25	MELK	1.30714790
26	OXSR1	1.29764769
27	NME1	1.29302276
28	MAPKAPK5	1.27738314
29	NEK2	1.25354222
30	PNCK	1.18084592
31	CAMK1D	1.13636135
32	PTK2B	1.02257356
33	MAP2K6	1.01821455
34	CAMK1G	1.00335735
35	MARK1	0.99841764
36	CHEK2	0.99230349
37	NLK	0.95487871
38	NTRK2	0.94786415
39	EPHB2	0.94204632
40	MAP2K4	0.84399509
41	MAP2K2	0.80717426
42	FGFR1	0.80238251
43	UHMK1	0.79745701
44	DAPK2	0.79347275
45	MAP3K9	0.73818100
46	RPS6KA5	0.71364659
47	BCKDK	0.69302058
48	TNIK	0.68701058
49	PKN1	0.67059071
50	CAMK2A	0.66477109
51	MAPK15	0.65951664
52	ERBB2	0.65076173
53	MAPK12	0.64034973
54	BUB1	0.61590413
55	CHUK	0.60206412
56	PAK3	0.59715563
57	STK38	0.59675257
58	FLT3	0.59393263
59	CSNK1G1	0.58318177
60	EIF2AK3	0.57616875
61	PDPK1	0.57492859
62	PRKAA2	0.56511101
63	MAP3K7	0.53643433
64	MAP2K1	0.53482234
65	TAF1	0.52874939
66	TIE1	0.52753529
67	MET	0.51604964
68	MAP2K3	0.49870147
69	TEC	0.48903271
70	CAMK4	0.48817539
71	WEE1	0.48714269
72	PRKCG	0.46841065
73	CAMK2B	0.45735642
74	FGFR3	0.45290715
75	STK11	0.44782789
76	MATK	0.43946940
77	STK10	0.43732250
78	PIK3CA	0.42277332
79	STK39	0.41594621
80	IKBKB	0.41162267
81	VRK1	0.39337501
82	MAP3K12	0.39150495
83	PIM1	0.37957274
84	PRKACA	0.37934447
85	ITK	0.37914657
86	TAOK3	0.37419274
87	PDK1	0.37138599
88	DYRK2	0.36131486
89	GRK7	0.33776688
90	PRKCE	0.32713372
91	MUSK	0.32345466
92	CAMK1	0.32307676
93	GSK3A	0.31134894
94	CSNK1G2	0.30861225
95	PRKCQ	0.28886885
96	PRKACB	0.28530998
97	MAP3K5	0.27781879
98	NEK9	0.26175151
99	TLK1	0.25440706
100	CSNK1A1	0.25316950

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.50995306
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.25025230
3	Nicotine addiction_Homo sapiens_hsa05033	3.54180801
4	Phototransduction_Homo sapiens_hsa04744	3.50340410
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.95938415
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.64412521
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.40649469
8	Caffeine metabolism_Homo sapiens_hsa00232	2.25140820
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19849818
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.19125041
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.14750029
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.13931774
13	Butanoate metabolism_Homo sapiens_hsa00650	2.02122792
14	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.78461712
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77258996
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.70935432
17	Taste transduction_Homo sapiens_hsa04742	1.62239658
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.61392156
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.61045582
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58845180
21	Basal transcription factors_Homo sapiens_hsa03022	1.57777351
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.56006657
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.50740589
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.48406688
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.42758650
26	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.42114388
27	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.40525882
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.40255522
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.37163410
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.36065806
31	Serotonergic synapse_Homo sapiens_hsa04726	1.35242917
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.28043544
33	Glycerolipid metabolism_Homo sapiens_hsa00561	1.25614479
34	Olfactory transduction_Homo sapiens_hsa04740	1.25444147
35	Morphine addiction_Homo sapiens_hsa05032	1.23369427
36	Sphingolipid metabolism_Homo sapiens_hsa00600	1.13990028
37	One carbon pool by folate_Homo sapiens_hsa00670	1.12081556
38	Parkinsons disease_Homo sapiens_hsa05012	1.06935334
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06284882
40	Calcium signaling pathway_Homo sapiens_hsa04020	1.01564969
41	Glutamatergic synapse_Homo sapiens_hsa04724	0.97552493
42	GABAergic synapse_Homo sapiens_hsa04727	0.96443991
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93491404
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93264792
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89314011
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.87844074
47	RNA polymerase_Homo sapiens_hsa03020	0.87756559
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.86991581
49	Long-term depression_Homo sapiens_hsa04730	0.83549439
50	Propanoate metabolism_Homo sapiens_hsa00640	0.83476824
51	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.82467197
52	Protein export_Homo sapiens_hsa03060	0.81285567
53	Cocaine addiction_Homo sapiens_hsa05030	0.80423990
54	ABC transporters_Homo sapiens_hsa02010	0.77564643
55	Sulfur metabolism_Homo sapiens_hsa00920	0.75991293
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75416808
57	Homologous recombination_Homo sapiens_hsa03440	0.73459388
58	Huntingtons disease_Homo sapiens_hsa05016	0.71884311
59	Retinol metabolism_Homo sapiens_hsa00830	0.70919903
60	Histidine metabolism_Homo sapiens_hsa00340	0.66546332
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.63040962
62	Ribosome_Homo sapiens_hsa03010	0.61313431
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61181375
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.60762163
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56225483
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.56177999
67	Gastric acid secretion_Homo sapiens_hsa04971	0.53894699
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53639979
69	Glutathione metabolism_Homo sapiens_hsa00480	0.50694908
70	Alzheimers disease_Homo sapiens_hsa05010	0.50545015
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49172099
72	Metabolic pathways_Homo sapiens_hsa01100	0.45373579
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44798977
74	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44244175
75	Cholinergic synapse_Homo sapiens_hsa04725	0.43457225
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.42477997
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41829889
78	Peroxisome_Homo sapiens_hsa04146	0.38753386
79	Purine metabolism_Homo sapiens_hsa00230	0.38495604
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38261334
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38092165
82	Salivary secretion_Homo sapiens_hsa04970	0.37806843
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36162482
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.36024156
85	Circadian entrainment_Homo sapiens_hsa04713	0.33945173
86	Pancreatic secretion_Homo sapiens_hsa04972	0.33306624
87	Amphetamine addiction_Homo sapiens_hsa05031	0.32761259
88	Mineral absorption_Homo sapiens_hsa04978	0.32697351
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.31935786
90	Insulin secretion_Homo sapiens_hsa04911	0.30495757
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.29228059
92	Regulation of autophagy_Homo sapiens_hsa04140	0.29089988
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.28712444
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28251633
95	Sulfur relay system_Homo sapiens_hsa04122	0.28024323
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27414455
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26854488
98	Bile secretion_Homo sapiens_hsa04976	0.24200339
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.24075908
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23527519

FAM197Y9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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