FAM198A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.05780071
2blood coagulation, intrinsic pathway (GO:0007597)6.70503297
3low-density lipoprotein particle remodeling (GO:0034374)6.65610013
4adenosine receptor signaling pathway (GO:0001973)6.53574336
5negative regulation of norepinephrine secretion (GO:0010700)6.44985745
6regulation of cholesterol esterification (GO:0010872)6.12755619
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75702470
8polyketide metabolic process (GO:0030638)5.63163055
9doxorubicin metabolic process (GO:0044598)5.63163055
10daunorubicin metabolic process (GO:0044597)5.63163055
11regulation of integrin-mediated signaling pathway (GO:2001044)5.24281604
12L-phenylalanine catabolic process (GO:0006559)5.21369800
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.21369800
14negative regulation of platelet activation (GO:0010544)5.11418679
15plasma lipoprotein particle remodeling (GO:0034369)5.07555975
16protein-lipid complex remodeling (GO:0034368)5.07555975
17macromolecular complex remodeling (GO:0034367)5.07555975
18negative regulation of catecholamine secretion (GO:0033604)4.97150789
19regulation of platelet activation (GO:0010543)4.90224639
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.84641239
21L-phenylalanine metabolic process (GO:0006558)4.84641239
22aromatic amino acid family catabolic process (GO:0009074)4.81920275
23negative regulation of heart rate (GO:0010459)4.81410867
24high-density lipoprotein particle remodeling (GO:0034375)4.79268280
25thrombin receptor signaling pathway (GO:0070493)4.76688281
26alpha-linolenic acid metabolic process (GO:0036109)4.70839614
27reverse cholesterol transport (GO:0043691)4.69028078
28dicarboxylic acid biosynthetic process (GO:0043650)4.62585516
29negative regulation of homotypic cell-cell adhesion (GO:0034111)4.53666396
30platelet aggregation (GO:0070527)4.50583491
31indole-containing compound catabolic process (GO:0042436)4.49590549
32indolalkylamine catabolic process (GO:0046218)4.49590549
33tryptophan catabolic process (GO:0006569)4.49590549
34regulation of norepinephrine secretion (GO:0014061)4.35296240
35very-low-density lipoprotein particle assembly (GO:0034379)4.24593120
36tryptophan metabolic process (GO:0006568)4.24553029
37plasma lipoprotein particle organization (GO:0071827)4.21521399
38relaxation of smooth muscle (GO:0044557)4.21157232
39phospholipid efflux (GO:0033700)4.17878145
40kynurenine metabolic process (GO:0070189)4.12723805
41lipoxygenase pathway (GO:0019372)4.12574805
42positive regulation of endothelial cell differentiation (GO:0045603)4.12271057
43neutrophil activation involved in immune response (GO:0002283)4.09077455
44regulation of platelet aggregation (GO:0090330)4.06720003
45bile acid biosynthetic process (GO:0006699)4.05469971
46platelet degranulation (GO:0002576)3.97564799
47amine catabolic process (GO:0009310)3.95793722
48cellular biogenic amine catabolic process (GO:0042402)3.95793722
49amino-acid betaine metabolic process (GO:0006577)3.92978566
50positive regulation of systemic arterial blood pressure (GO:0003084)3.90915361
51plasma lipoprotein particle assembly (GO:0034377)3.89070170
52protein-lipid complex subunit organization (GO:0071825)3.87677521
53negative regulation of heart contraction (GO:0045822)3.85721604
54regulation of activation of Janus kinase activity (GO:0010533)3.85649652
55sulfur amino acid catabolic process (GO:0000098)3.83316305
56negative regulation of protein localization to cell surface (GO:2000009)3.82762496
57homocysteine metabolic process (GO:0050667)3.75900057
58positive regulation of receptor recycling (GO:0001921)3.75451480
59cysteine metabolic process (GO:0006534)3.74422650
60negative regulation of appetite (GO:0032099)3.74201784
61negative regulation of response to food (GO:0032096)3.74201784
62peptidyl-glutamic acid carboxylation (GO:0017187)3.73219717
63protein carboxylation (GO:0018214)3.73219717
64glyoxylate metabolic process (GO:0046487)3.72863001
65regulation of lipoprotein metabolic process (GO:0050746)3.70671119
66positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.69500594
67serine family amino acid catabolic process (GO:0009071)3.67657012
68glutamate metabolic process (GO:0006536)3.67446131
69urea cycle (GO:0000050)3.63369901
70urea metabolic process (GO:0019627)3.63369901
71myelination in peripheral nervous system (GO:0022011)3.62550078
72peripheral nervous system axon ensheathment (GO:0032292)3.62550078
73leukocyte migration involved in inflammatory response (GO:0002523)3.62254746
74regulation of fibrinolysis (GO:0051917)3.62140807
75cholesterol efflux (GO:0033344)3.59908211
76positive regulation of cellular amide metabolic process (GO:0034250)3.59894560
77negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.58362923
78negative regulation of fibrinolysis (GO:0051918)3.57635839
79regulation of female receptivity (GO:0045924)3.56060226
80bile acid metabolic process (GO:0008206)3.54733294
81cerebellar granule cell differentiation (GO:0021707)3.53151689
82regulation of triglyceride catabolic process (GO:0010896)3.53092485
83beta-amyloid metabolic process (GO:0050435)3.50948019
84negative regulation of sterol transport (GO:0032372)3.50518099
85negative regulation of cholesterol transport (GO:0032375)3.50518099
86carnitine metabolic process (GO:0009437)3.49315144
87dopamine transport (GO:0015872)3.49036645
88regulation of protein activation cascade (GO:2000257)3.48986254
89linoleic acid metabolic process (GO:0043651)3.48314790
90drinking behavior (GO:0042756)3.48207474
91alpha-amino acid catabolic process (GO:1901606)3.46478475
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44968782
93gamma-aminobutyric acid transport (GO:0015812)3.44322011
94endothelium development (GO:0003158)3.44081216
95behavioral response to cocaine (GO:0048148)3.42142691
96aminoglycoside antibiotic metabolic process (GO:0030647)3.41818568
97extracellular fibril organization (GO:0043206)3.40128116
98ethanol oxidation (GO:0006069)3.38268582
99angiogenesis involved in wound healing (GO:0060055)3.37298170
100complement activation, alternative pathway (GO:0006957)3.36370173
101negative regulation of neural precursor cell proliferation (GO:2000178)3.36118714
102positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.35406304
103aromatic amino acid family metabolic process (GO:0009072)3.34474115
104protein-lipid complex assembly (GO:0065005)3.34389183
105tyrosine metabolic process (GO:0006570)3.32979296
106regulation of clathrin-mediated endocytosis (GO:2000369)3.31622378
107long-chain fatty acid biosynthetic process (GO:0042759)3.29924023
108positive regulation of cAMP-mediated signaling (GO:0043950)3.29301513
109negative regulation of sodium ion transport (GO:0010766)3.28319759
110C4-dicarboxylate transport (GO:0015740)3.26025873
111cellular modified amino acid catabolic process (GO:0042219)3.25667601
112vesicle targeting (GO:0006903)3.25262694
113plasma lipoprotein particle clearance (GO:0034381)3.24157238
114negative regulation of thymocyte apoptotic process (GO:0070244)3.23693714
115nitrogen cycle metabolic process (GO:0071941)3.23198190
116regulation of Golgi to plasma membrane protein transport (GO:0042996)3.22448351
117tonic smooth muscle contraction (GO:0014820)3.21334528
118purine nucleotide transport (GO:0015865)3.20561219
119platelet activation (GO:0030168)3.19848036
120regulation of complement activation (GO:0030449)3.19643942
121negative regulation of muscle contraction (GO:0045932)3.19482598
122triglyceride homeostasis (GO:0070328)3.18520954
123acylglycerol homeostasis (GO:0055090)3.18520954
124cholesterol catabolic process (GO:0006707)3.17357691
125sterol catabolic process (GO:0016127)3.17357691
126negative regulation of amine transport (GO:0051953)3.17114577
127cellular amino acid catabolic process (GO:0009063)3.16791219
128coenzyme catabolic process (GO:0009109)3.15269602
129alanine transport (GO:0032328)3.14592738
130short-chain fatty acid metabolic process (GO:0046459)3.14204921
131imidazole-containing compound metabolic process (GO:0052803)3.13991653
132gap junction assembly (GO:0016264)3.13066869
133cellular response to cholesterol (GO:0071397)3.12075750
134phospholipid homeostasis (GO:0055091)3.11613024
135female mating behavior (GO:0060180)3.11014909
136indolalkylamine metabolic process (GO:0006586)3.10634126
137positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09938360
138G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.09518342
139neurotransmitter uptake (GO:0001504)3.08872949
140cGMP-mediated signaling (GO:0019934)3.07053089
141purine ribonucleotide transport (GO:0015868)3.06370835
142negative regulation of hemostasis (GO:1900047)3.04467318
143negative regulation of blood coagulation (GO:0030195)3.04467318
144drug catabolic process (GO:0042737)3.04229281
145fusion of sperm to egg plasma membrane (GO:0007342)3.03964699
146cellular ketone body metabolic process (GO:0046950)3.03727850
147regulation of cholesterol efflux (GO:0010874)3.02228954
148positive regulation of fatty acid biosynthetic process (GO:0045723)3.01407892
149regulation of sensory perception of pain (GO:0051930)3.01291496
150regulation of sensory perception (GO:0051931)3.01291496
151bile acid and bile salt transport (GO:0015721)3.01196255
152G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98784410
153positive regulation of steroid metabolic process (GO:0045940)2.96499120
154relaxation of muscle (GO:0090075)2.96189929
155cellular glucuronidation (GO:0052695)2.94253900
156opsonization (GO:0008228)2.94122927
157regulation of endothelial cell differentiation (GO:0045601)2.93847904
158homotypic cell-cell adhesion (GO:0034109)2.93443365
159positive regulation of hemostasis (GO:1900048)2.92683238
160positive regulation of blood coagulation (GO:0030194)2.92683238
161lipoprotein metabolic process (GO:0042157)2.91158078
162fibrinolysis (GO:0042730)2.90301208
163regulation of renal sodium excretion (GO:0035813)2.90202653
164lysine metabolic process (GO:0006553)2.90018237
165lysine catabolic process (GO:0006554)2.90018237
166arginine metabolic process (GO:0006525)2.87721127
167negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.87560253
168positive regulation of Rho protein signal transduction (GO:0035025)2.86122844
169adenine nucleotide transport (GO:0051503)2.85026895
170negative regulation of lipase activity (GO:0060192)2.84334595
171fatty acid elongation (GO:0030497)2.83996588
172positive regulation of mast cell activation (GO:0033005)2.83693692
173regulation of cholesterol biosynthetic process (GO:0045540)2.83691114
174amino acid import (GO:0043090)2.83677594
175regulation of integrin activation (GO:0033623)2.82101084
176regulation of inositol phosphate biosynthetic process (GO:0010919)2.74253427
177negative regulation of blood circulation (GO:1903523)2.72095936
178negative regulation of protein localization to plasma membrane (GO:1903077)2.72011079
179purinergic receptor signaling pathway (GO:0035587)2.71416806
180regulation of response to food (GO:0032095)2.71194639
181positive regulation of SMAD protein import into nucleus (GO:0060391)2.67597839
182polyamine biosynthetic process (GO:0006596)2.65175784
183regulation of macrophage derived foam cell differentiation (GO:0010743)2.65054005
184negative regulation of coagulation (GO:0050819)2.62926810
185negative regulation of smooth muscle contraction (GO:0045986)2.62178505
186positive regulation of coagulation (GO:0050820)2.58085148
187cyclooxygenase pathway (GO:0019371)2.57304737
188fibril organization (GO:0097435)2.56573827
189male genitalia development (GO:0030539)2.56281982
190platelet formation (GO:0030220)2.56222840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.33868367
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.36329989
3* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.20383799
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.79375689
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.60221026
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.52133534
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.28498097
8GBX2_23144817_ChIP-Seq_PC3_Human3.24217201
9SCL_19346495_ChIP-Seq_HPC-7_Human3.09827128
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.79670988
11* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.46209922
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.39774315
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.27226232
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17803874
15GATA1_19941826_ChIP-Seq_K562_Human2.06570107
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.05100755
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97502076
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92678318
19GATA1_19941827_ChIP-Seq_MEL_Mouse1.90755959
20EZH2_22144423_ChIP-Seq_EOC_Human1.89344182
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88810232
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83574040
23GATA2_19941826_ChIP-Seq_K562_Human1.80010331
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76251829
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.75021712
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74664471
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70569310
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70449508
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.68364981
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67509514
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.65750564
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63627459
33AR_21572438_ChIP-Seq_LNCaP_Human1.57308513
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.57230491
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54196778
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52708845
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51548319
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47212810
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43550192
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43550192
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43373356
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42255016
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41106458
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41106458
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41106458
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40476316
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39029905
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38822978
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37957006
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37922930
51P300_19829295_ChIP-Seq_ESCs_Human1.37744229
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36665397
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35339670
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35121465
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34032647
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31612173
57BCAT_22108803_ChIP-Seq_LS180_Human1.31439699
58DROSHA_22980978_ChIP-Seq_HELA_Human1.30125632
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30084482
60HTT_18923047_ChIP-ChIP_STHdh_Human1.28419314
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28137902
62GATA1_19941827_ChIP-Seq_MEL86_Mouse1.27968816
63RXR_22108803_ChIP-Seq_LS180_Human1.27216812
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26409001
65* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26068171
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25654859
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24357356
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22193860
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20902358
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20855879
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.19099367
72* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18894095
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18454339
74TAF15_26573619_Chip-Seq_HEK293_Human1.16164553
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.15509369
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15331593
77AR_25329375_ChIP-Seq_VCAP_Human1.14295460
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.14039333
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13809939
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13635470
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13159729
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.12340928
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10878548
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09760488
85SMAD4_21799915_ChIP-Seq_A2780_Human1.09697344
86TP53_18474530_ChIP-ChIP_U2OS_Human1.09572086
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09067014
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09067014
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.07970805
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06448959
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06380897
92REST_21632747_ChIP-Seq_MESCs_Mouse1.05742573
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04650098
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04047088
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03913634
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.02515974
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.02433564
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01028483
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00850581
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00674360
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99718451
102RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99435979
103TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98943054
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98135418
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97109112
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96842704
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96275709
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96075974
109GF1_26923725_Chip-Seq_HPCs_Mouse0.95351544
110STAT3_23295773_ChIP-Seq_U87_Human0.94787518
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.92896174
112SOX2_21211035_ChIP-Seq_LN229_Gbm0.92776413
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92421170
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92057566
115RNF2_27304074_Chip-Seq_NSC_Mouse0.91913825
116GATA1_22025678_ChIP-Seq_K562_Human0.91446579
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.91396258
118* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90985653
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90803415
120CBX2_27304074_Chip-Seq_ESCs_Mouse0.89405659
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88757948
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88568702
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87413171
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86865874
125TP53_16413492_ChIP-PET_HCT116_Human0.86811810
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86520184
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86457207
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.86106746
129TCF4_22108803_ChIP-Seq_LS180_Human0.86057143
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86049719
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84670546
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84455432
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83941945
134* RUNX2_22187159_ChIP-Seq_PCA_Human0.83471119
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.82939607
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81754082
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81196723
138CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81147515
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81019488
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80913245
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.80761306
142P53_22387025_ChIP-Seq_ESCs_Mouse0.80534675
143KDM2B_26808549_Chip-Seq_REH_Human0.80436125
144VDR_24787735_ChIP-Seq_THP-1_Human0.80269705
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80130178
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.80118135
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79841451
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.79345066
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.78777054
150HNF4A_19822575_ChIP-Seq_HepG2_Human0.78065439
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77948723
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77385122
153SPI1_23127762_ChIP-Seq_K562_Human0.76885243
154KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.76737447
155OCT1_27270436_Chip-Seq_PROSTATE_Human0.76636831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.35049410
2MP0002139_abnormal_hepatobiliary_system6.66960484
3MP0005360_urolithiasis5.21836656
4MP0005085_abnormal_gallbladder_physiolo4.99586237
5MP0005365_abnormal_bile_salt4.69250824
6MP0008875_abnormal_xenobiotic_pharmacok3.66917170
7MP0010329_abnormal_lipoprotein_level3.30553542
8MP0003252_abnormal_bile_duct3.11116356
9MP0009840_abnormal_foam_cell3.00241817
10MP0005332_abnormal_amino_acid2.49616271
11MP0001879_abnormal_lymphatic_vessel2.47912214
12MP0003806_abnormal_nucleotide_metabolis2.44355084
13MP0009697_abnormal_copulation2.37726708
14MP0009384_cardiac_valve_regurgitation2.35848279
15MP0003566_abnormal_cell_adhesion2.34815633
16MP0004084_abnormal_cardiac_muscle2.32591605
17MP0005083_abnormal_biliary_tract2.28083335
18MP0004510_myositis2.21501748
19MP0005058_abnormal_lysosome_morphology2.13578532
20MP0005646_abnormal_pituitary_gland2.13093145
21MP0000566_synostosis2.11714459
22MP0003941_abnormal_skin_development2.02727902
23MP0003690_abnormal_glial_cell2.01345723
24MP0004885_abnormal_endolymph1.98049201
25MP0005377_hearing/vestibular/ear_phenot1.95876707
26MP0003878_abnormal_ear_physiology1.95876707
27MP0004036_abnormal_muscle_relaxation1.95094470
28MP0002254_reproductive_system_inflammat1.92087208
29MP0003195_calcinosis1.91970873
30MP0000343_altered_response_to1.88746858
31MP0004019_abnormal_vitamin_homeostasis1.86555705
32MP0003011_delayed_dark_adaptation1.84161966
33MP0005167_abnormal_blood-brain_barrier1.81344614
34MP0001666_abnormal_nutrient_absorption1.80594220
35MP0003880_abnormal_central_pattern1.79568090
36MP0002118_abnormal_lipid_homeostasis1.70990481
37MP0000465_gastrointestinal_hemorrhage1.67513836
38MP0000579_abnormal_nail_morphology1.65026858
39MP0003136_yellow_coat_color1.58528957
40MP0010368_abnormal_lymphatic_system1.57458707
41MP0004215_abnormal_myocardial_fiber1.57198335
42MP0005187_abnormal_penis_morphology1.55774414
43MP0003453_abnormal_keratinocyte_physiol1.55727092
44MP0005647_abnormal_sex_gland1.55117983
45MP0002733_abnormal_thermal_nociception1.54101442
46MP0004130_abnormal_muscle_cell1.49454502
47MP0003279_aneurysm1.48551037
48MP0000609_abnormal_liver_physiology1.48065294
49MP0003868_abnormal_feces_composition1.47297724
50MP0005645_abnormal_hypothalamus_physiol1.47241977
51MP0002138_abnormal_hepatobiliary_system1.43772546
52MP0001486_abnormal_startle_reflex1.41334423
53MP0005319_abnormal_enzyme/_coenzyme1.39467098
54MP0004859_abnormal_synaptic_plasticity1.36656321
55MP0005023_abnormal_wound_healing1.36458881
56MP0006138_congestive_heart_failure1.35022848
57MP0005410_abnormal_fertilization1.34360334
58MP0001986_abnormal_taste_sensitivity1.33015087
59MP0010386_abnormal_urinary_bladder1.32512072
60MP0009780_abnormal_chondrocyte_physiolo1.31898969
61MP0005666_abnormal_adipose_tissue1.31219731
62MP0003075_altered_response_to1.29654904
63MP0001919_abnormal_reproductive_system1.29443686
64MP0001756_abnormal_urination1.28970646
65MP0003191_abnormal_cellular_cholesterol1.27092241
66MP0009764_decreased_sensitivity_to1.21663753
67MP0000383_abnormal_hair_follicle1.21585248
68MP0008775_abnormal_heart_ventricle1.20205803
69MP0004272_abnormal_basement_membrane1.19146530
70MP0005171_absent_coat_pigmentation1.18322019
71MP0005584_abnormal_enzyme/coenzyme_acti1.17818723
72MP0003633_abnormal_nervous_system1.17149754
73MP0003724_increased_susceptibility_to1.17129100
74MP0001849_ear_inflammation1.15151448
75MP0002653_abnormal_ependyma_morphology1.14771833
76MP0002735_abnormal_chemical_nociception1.13720925
77MP0000249_abnormal_blood_vessel1.13320036
78MP0001970_abnormal_pain_threshold1.12869368
79MP0000604_amyloidosis1.12825632
80MP0001764_abnormal_homeostasis1.12800854
81MP0002876_abnormal_thyroid_physiology1.09153535
82MP0005670_abnormal_white_adipose1.07890115
83MP0004858_abnormal_nervous_system1.07254709
84MP0010030_abnormal_orbit_morphology1.06988723
85MP0006292_abnormal_olfactory_placode1.06756417
86MP0005501_abnormal_skin_physiology1.05130116
87MP0001485_abnormal_pinna_reflex1.01813526
88MP0003329_amyloid_beta_deposits0.99689856
89MP0001851_eye_inflammation0.99263897
90MP0005620_abnormal_muscle_contractility0.95935260
91MP0001502_abnormal_circadian_rhythm0.95783380
92MP0010352_gastrointestinal_tract_polyps0.95568172
93MP0000534_abnormal_ureter_morphology0.95372833
94MP0005248_abnormal_Harderian_gland0.92931125
95MP0009053_abnormal_anal_canal0.91907414
96MP0005503_abnormal_tendon_morphology0.91376482
97MP0008004_abnormal_stomach_pH0.90918592
98MP0000639_abnormal_adrenal_gland0.89589080
99MP0003879_abnormal_hair_cell0.88888819
100MP0009745_abnormal_behavioral_response0.88647708
101MP0002972_abnormal_cardiac_muscle0.86662658
102MP0001984_abnormal_olfaction0.86559514
103MP0002089_abnormal_postnatal_growth/wei0.85350958
104MP0003942_abnormal_urinary_system0.80781208
105MP0001661_extended_life_span0.80281390
106MP0001853_heart_inflammation0.79908876
107MP0003631_nervous_system_phenotype0.79488402
108MP0002736_abnormal_nociception_after0.79252470
109MP0002128_abnormal_blood_circulation0.78900461
110MP0001440_abnormal_grooming_behavior0.76806255
111MP0000428_abnormal_craniofacial_morphol0.76482433
112MP0002272_abnormal_nervous_system0.74700068
113MP0002249_abnormal_larynx_morphology0.74692575
114MP0008569_lethality_at_weaning0.73937871
115MP0003303_peritoneal_inflammation0.73155176
116MP0002928_abnormal_bile_duct0.72947058
117MP0005084_abnormal_gallbladder_morpholo0.72756257
118MP0002572_abnormal_emotion/affect_behav0.72437544
119MP0003828_pulmonary_edema0.71569752
120MP0003632_abnormal_nervous_system0.70839614
121MP0005551_abnormal_eye_electrophysiolog0.70558072
122MP0001663_abnormal_digestive_system0.70390808
123MP0005165_increased_susceptibility_to0.68561563
124MP0001963_abnormal_hearing_physiology0.66705370
125MP0003183_abnormal_peptide_metabolism0.65984790
126MP0001968_abnormal_touch/_nociception0.65965244
127MP0000026_abnormal_inner_ear0.65476831
128MP0005595_abnormal_vascular_smooth0.63599762
129MP0009643_abnormal_urine_homeostasis0.63175809
130MP0002067_abnormal_sensory_capabilities0.63065567
131MP0005385_cardiovascular_system_phenoty0.62733801
132MP0001544_abnormal_cardiovascular_syste0.62733801
133MP0002064_seizures0.62303433
134MP0002938_white_spotting0.62202970
135MP0005423_abnormal_somatic_nervous0.62006608
136MP0004043_abnormal_pH_regulation0.61464294
137MP0004085_abnormal_heartbeat0.60676693
138MP0005166_decreased_susceptibility_to0.60536417
139MP0003705_abnormal_hypodermis_morpholog0.59736763
140MP0002557_abnormal_social/conspecific_i0.59216421
141MP0000230_abnormal_systemic_arterial0.59003181
142MP0002078_abnormal_glucose_homeostasis0.58630794
143MP0008874_decreased_physiological_sensi0.58212766
144MP0005381_digestive/alimentary_phenotyp0.57949838
145MP0000762_abnormal_tongue_morphology0.57289862
146MP0009642_abnormal_blood_homeostasis0.57207633
147MP0001664_abnormal_digestion0.56052422
148MP0005275_abnormal_skin_tensile0.55294020
149MP0006276_abnormal_autonomic_nervous0.55065519
150MP0001501_abnormal_sleep_pattern0.54936991
151MP0004924_abnormal_behavior0.54891737
152MP0005386_behavior/neurological_phenoty0.54891737
153MP0003638_abnormal_response/metabolism_0.54736835
154MP0003656_abnormal_erythrocyte_physiolo0.54721365
155MP0001542_abnormal_bone_strength0.54112685
156MP0009763_increased_sensitivity_to0.53743516
157MP0008872_abnormal_physiological_respon0.51840094
158MP0003635_abnormal_synaptic_transmissio0.51517093
159MP0003634_abnormal_glial_cell0.49537780
160MP0005451_abnormal_body_composition0.47484506
161MP0002063_abnormal_learning/memory/cond0.47307593

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.75728848
2Increased mean platelet volume (HP:0011877)9.42882126
3Abnormal platelet volume (HP:0011876)8.56205139
4Purpura (HP:0000979)8.40352847
5Petechiae (HP:0000967)7.64651737
6Epistaxis (HP:0000421)6.41995652
7Deep venous thrombosis (HP:0002625)5.40055824
8Hyperlipoproteinemia (HP:0010980)5.37675714
9Intrahepatic cholestasis (HP:0001406)5.30457909
10Abnormality of aromatic amino acid family metabolism (HP:0004338)5.22718453
11Prolonged partial thromboplastin time (HP:0003645)5.19612127
12Xanthomatosis (HP:0000991)5.18278802
13Abnormal platelet function (HP:0011869)4.44315819
14Impaired platelet aggregation (HP:0003540)4.44315819
15Abnormality of monocarboxylic acid metabolism (HP:0010996)4.18215592
16Hyperglycinemia (HP:0002154)4.05712773
17Hypoalphalipoproteinemia (HP:0003233)4.01239099
18Hypobetalipoproteinemia (HP:0003563)3.97196748
19Spontaneous hematomas (HP:0007420)3.94796198
20Joint hemorrhage (HP:0005261)3.87195174
21Conjunctival telangiectasia (HP:0000524)3.77401686
22Hypolipoproteinemia (HP:0010981)3.70859069
23Parakeratosis (HP:0001036)3.67227082
24Vascular calcification (HP:0004934)3.62869010
25Mitral stenosis (HP:0001718)3.56638601
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.51387571
27Abnormality of methionine metabolism (HP:0010901)3.46066423
28Abnormality of glycine metabolism (HP:0010895)3.40996196
29Abnormality of serine family amino acid metabolism (HP:0010894)3.40996196
30Abnormal pupillary function (HP:0007686)3.39938559
31Follicular hyperkeratosis (HP:0007502)3.36474771
32Abnormal auditory evoked potentials (HP:0006958)3.36399201
33Cardiovascular calcification (HP:0011915)3.35617098
34Hyperglycinuria (HP:0003108)3.34577604
35Hyperammonemia (HP:0001987)3.34351143
36Potter facies (HP:0002009)3.31721834
37Facial shape deformation (HP:0011334)3.31721834
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.29244570
39Acanthocytosis (HP:0001927)3.28941127
40Alopecia of scalp (HP:0002293)3.27969621
41Ketosis (HP:0001946)3.26468980
42Epidermoid cyst (HP:0200040)3.23952914
43Complement deficiency (HP:0004431)3.20239835
44Abnormality of the vasculature of the conjunctiva (HP:0008054)3.13932345
45Split foot (HP:0001839)3.13859092
46Dyschromatopsia (HP:0007641)3.13244992
47Hypoplastic left heart (HP:0004383)3.09668550
48Abnormality of aspartate family amino acid metabolism (HP:0010899)3.09346167
49Hypercholesterolemia (HP:0003124)3.07537240
50Abnormality of the common coagulation pathway (HP:0010990)3.03412966
51Upper limb muscle weakness (HP:0003484)3.01074558
52Conjugated hyperbilirubinemia (HP:0002908)3.00211290
53Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00074795
54Hypoglycemic coma (HP:0001325)2.98997780
55Poikilocytosis (HP:0004447)2.96922928
56Aplasia involving bones of the extremities (HP:0009825)2.89618179
57Aplasia involving bones of the upper limbs (HP:0009823)2.89618179
58Aplasia of the phalanges of the hand (HP:0009802)2.89618179
59Fat malabsorption (HP:0002630)2.82287312
60Recurrent corneal erosions (HP:0000495)2.73870381
61Systemic lupus erythematosus (HP:0002725)2.70954410
62Hemiparesis (HP:0001269)2.70408222
63Hypoglycemic seizures (HP:0002173)2.70105850
64Ketoacidosis (HP:0001993)2.69966963
65Abnormality of the axillary hair (HP:0100134)2.69913964
66Abnormality of secondary sexual hair (HP:0009888)2.69913964
67Delayed CNS myelination (HP:0002188)2.69357803
68Hemiplegia (HP:0002301)2.65433678
69Paralysis (HP:0003470)2.63174607
70Paraparesis (HP:0002385)2.61882201
71Renal cortical cysts (HP:0000803)2.61024402
72Bruising susceptibility (HP:0000978)2.60887972
73Hyperventilation (HP:0002883)2.59020989
74Widely patent fontanelles and sutures (HP:0004492)2.55427207
75Abnormality of fatty-acid metabolism (HP:0004359)2.53126101
76Enlarged kidneys (HP:0000105)2.49988837
77Confusion (HP:0001289)2.49439578
78Hypoplastic heart (HP:0001961)2.48513702
79Chronic hepatic failure (HP:0100626)2.41692175
80Abnormality of the intrinsic pathway (HP:0010989)2.39218672
81Tongue fasciculations (HP:0001308)2.35484734
82Neurofibrillary tangles (HP:0002185)2.32092292
83Hyperbilirubinemia (HP:0002904)2.28550924
84Absent hair (HP:0002298)2.27439670
85Abnormality of pyrimidine metabolism (HP:0004353)2.26071409
86Tetraparesis (HP:0002273)2.23287915
87Hypophosphatemic rickets (HP:0004912)2.21666311
88Basal ganglia calcification (HP:0002135)2.20444248
89Distal lower limb amyotrophy (HP:0008944)2.19339245
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18534189
91Gingival bleeding (HP:0000225)2.16155257
92Increased density of long bones (HP:0006392)2.16108685
93Generalized aminoaciduria (HP:0002909)2.15346085
94Myocardial infarction (HP:0001658)2.14218725
95Steatorrhea (HP:0002570)2.14067269
96Lower limb amyotrophy (HP:0007210)2.12723443
97Hepatocellular carcinoma (HP:0001402)2.12299280
98Abnormality of serum amino acid levels (HP:0003112)2.11760055
99Metabolic acidosis (HP:0001942)2.10750935
100Abnormality of complement system (HP:0005339)2.10608881
101Abnormality of lateral ventricle (HP:0030047)2.10512176
102Decreased central vision (HP:0007663)2.10053176
103Insidious onset (HP:0003587)2.09505513
104Termporal pattern (HP:0011008)2.09505513
105Abnormality of the diencephalon (HP:0010662)2.07968877
106Hyperthyroidism (HP:0000836)2.07846996
107Spastic paraparesis (HP:0002313)2.01774374
108Spontaneous abortion (HP:0005268)2.00359801
109Menorrhagia (HP:0000132)10.0912590
110Myokymia (HP:0002411)1.98561492
111Bile duct proliferation (HP:0001408)1.97577006
112Abnormal biliary tract physiology (HP:0012439)1.97577006
113Back pain (HP:0003418)1.97242917
114Sensorimotor neuropathy (HP:0007141)1.96744795
115Dry hair (HP:0011359)1.95694753
116Biliary tract neoplasm (HP:0100574)1.95399512
117Abnormality of nucleobase metabolism (HP:0010932)1.95050764
118Muscle fibrillation (HP:0010546)1.94951879
119Esophageal varix (HP:0002040)1.94545008
120Clumsiness (HP:0002312)1.93955939
121Tinnitus (HP:0000360)1.93666582
122Hepatosplenomegaly (HP:0001433)1.92820486
123Status epilepticus (HP:0002133)1.92718518
124Increased variability in muscle fiber diameter (HP:0003557)1.90755294
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88932490
126Dicarboxylic aciduria (HP:0003215)1.88932490
127Aortic aneurysm (HP:0004942)1.86423659
128Abnormality of the Achilles tendon (HP:0005109)1.86396066
129Mesangial abnormality (HP:0001966)1.84854076
130Amyloidosis (HP:0011034)1.84755151
131Rickets (HP:0002748)1.83405059
132Late onset (HP:0003584)1.82515644
133Abnormality of proline metabolism (HP:0010907)1.81913982
134Hydroxyprolinuria (HP:0003080)1.81913982
135Thyroid-stimulating hormone excess (HP:0002925)1.81680602
136Mixed hearing impairment (HP:0000410)1.81441497
137Abnormal eating behavior (HP:0100738)1.81282822
138Symptomatic seizures (HP:0011145)1.80946265
139Lethargy (HP:0001254)1.80890436
140Absent eyelashes (HP:0000561)1.80144521
141Abnormality of purine metabolism (HP:0004352)1.79540442
142Patent foramen ovale (HP:0001655)1.78035483
143Congenital, generalized hypertrichosis (HP:0004540)1.77286766
144Opisthotonus (HP:0002179)1.76947014
145Cerebral inclusion bodies (HP:0100314)1.76023729
146Recurrent gram-negative bacterial infections (HP:0005420)1.75295805
147Gout (HP:0001997)1.75283979
148Pseudobulbar signs (HP:0002200)1.74764601
149Abnormality of skeletal muscle fiber size (HP:0012084)1.74452466
150Testicular neoplasm (HP:0010788)1.73416880
151Leiomyosarcoma (HP:0100243)1.72953754
152Uterine leiomyosarcoma (HP:0002891)1.72953754
153Atrioventricular block (HP:0001678)1.71498131
154Glomerulosclerosis (HP:0000096)1.70358390
155Hypoplasia of the iris (HP:0007676)1.68443987
156Ventricular fibrillation (HP:0001663)1.68140708
157Muscle fiber splitting (HP:0003555)1.66879032
158Action tremor (HP:0002345)1.56907235
159Abnormal large intestine physiology (HP:0012700)1.56862187
160Malignant gastrointestinal tract tumors (HP:0006749)1.55791780
161Gastrointestinal carcinoma (HP:0002672)1.55791780
162Glomerulonephritis (HP:0000099)1.54200055
163Neoplasm of the small intestine (HP:0100833)1.50262128
164Abnormality of the heme biosynthetic pathway (HP:0010472)1.50196590
165Focal segmental glomerulosclerosis (HP:0000097)1.49555008
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.49547521
167Transitional cell carcinoma of the bladder (HP:0006740)1.49265162
168Arthropathy (HP:0003040)1.48003251
169Nausea (HP:0002018)1.47169365
170Polyphagia (HP:0002591)1.47077521
171Nephritis (HP:0000123)1.44962503
172Concave nail (HP:0001598)1.44762491
173Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.44414883
174Joint swelling (HP:0001386)1.41941724
175Papillary thyroid carcinoma (HP:0002895)1.41279511
176Infertility (HP:0000789)1.38946602
177Stroke (HP:0001297)1.38434905
178Delayed epiphyseal ossification (HP:0002663)1.36136929
179Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.34031270
180Short middle phalanx of the 5th finger (HP:0004220)1.32211902
181Male infertility (HP:0003251)1.32191150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.15314934
2MST44.86577402
3BMX4.73380242
4SIK33.53911020
5PNCK3.23991423
6MUSK3.12971052
7EPHA42.89987202
8CASK2.85204560
9INSRR2.78167137
10LATS12.74569652
11BCKDK2.73021583
12TNIK2.62497339
13ZAK2.19041738
14MAPK122.18244842
15SIK22.18168000
16ILK2.12066526
17TEC2.11491787
18BTK2.08269985
19STK31.93415885
20GRK51.90512516
21SGK21.89872962
22ADRBK21.87976802
23MAP2K71.86547564
24MAPK71.86089727
25MAPKAPK31.85491723
26PTK2B1.79861918
27DAPK31.64847157
28EIF2AK11.58268030
29DAPK21.48855310
30MAPK111.46205642
31IRAK31.45531442
32LMTK21.43553947
33SGK31.39255031
34PHKG21.37535477
35PHKG11.37535477
36MAP2K41.35873550
37STK38L1.35652434
38NTRK31.33758688
39TNK21.33236857
40PINK11.31740202
41SGK4941.27389098
42SGK2231.27389098
43ERBB41.22454447
44ERBB21.20634234
45STK241.20120080
46PRKCG1.19877352
47RET1.18477712
48TAOK31.17858277
49BLK1.16461925
50DMPK1.16252558
51FGFR41.15479266
52NTRK21.15311101
53PLK21.15204285
54MAPK131.14745426
55DDR21.14495462
56BMPR21.12714093
57CAMK2B1.08864807
58PAK11.06859640
59FER1.05475371
60MAP3K121.04321503
61FRK1.04296338
62TXK1.00200679
63PRPF4B0.98124746
64TAOK20.97778698
65RIPK40.94958586
66CAMK1G0.93137170
67FLT30.89066752
68FGFR20.88398471
69NLK0.87984764
70MAP3K40.87694956
71PKN20.85759109
72PDGFRB0.84867956
73MAP3K140.83580713
74PRKD10.83196811
75ERN10.83028782
76FES0.82959862
77CAMKK20.82138699
78SYK0.79208043
79PRKCE0.78405227
80IGF1R0.77177767
81ZAP700.76646189
82DYRK20.75165450
83IRAK10.75123922
84PRKAA20.74832625
85PAK20.73686258
86SGK10.73513003
87MAPK40.72982555
88MAPKAPK50.72704495
89STK380.71552155
90MAP3K70.71415991
91YES10.71113461
92EPHA30.71040313
93LATS20.70365595
94ADRBK10.69316564
95MYLK0.69308245
96AKT30.66815206
97EPHB20.65960238
98HCK0.64705943
99MINK10.64643062
100CAMKK10.64462152
101PDGFRA0.64037245
102TLK10.63281866
103ROCK10.63174302
104PRKCZ0.62832186
105PIK3CG0.61576795
106MARK20.60960812
107MARK30.60766898
108NTRK10.59818651
109JAK30.57612668
110MAPK150.56321589
111NEK90.55476478
112GRK10.55218127
113MST1R0.55083685
114CAMK2D0.54921828
115CDC70.52882196
116CAMK40.52807380
117CAMK2A0.52802255
118TIE10.52571506
119FGR0.52126121
120CAMK2G0.51679273
121DAPK10.50994709
122PRKACG0.50799841
123BRSK20.48999088
124CAMK10.48508459
125PRKCH0.48218674
126MKNK20.47138373
127PRKCQ0.46186132
128ARAF0.46125457
129PRKAA10.45706861
130RIPK10.45411747
131MAP3K130.45290760
132GRK70.44944889
133PRKG10.44887631
134MAP2K60.43327365
135PRKCA0.42708596
136CSF1R0.42634620
137CDC42BPA0.42464336
138NEK60.42379014
139PIK3CA0.41238763
140CAMK1D0.39413959
141LYN0.39033293
142ROCK20.38734562
143PKN10.38611410
144MET0.38068434
145PDPK10.37752085
146ACVR1B0.36988629
147PRKACA0.36652929
148IRAK20.36529083
149ABL20.36383210
150ERBB30.36110610
151MAP3K50.35643172
152SRC0.35369185
153TGFBR20.35222593
154DYRK1A0.34675510
155PRKD30.34642081
156RPS6KB10.34601611
157MAP2K10.34285483
158TRIB30.34176026
159JAK20.33714957
160TYRO30.33683058
161RPS6KA50.33589153
162JAK10.31868815
163GRK60.31829982

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.33097808
2Nitrogen metabolism_Homo sapiens_hsa009104.06152689
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.73431746
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.01875008
5ECM-receptor interaction_Homo sapiens_hsa045122.82352221
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67445626
7Fatty acid degradation_Homo sapiens_hsa000712.67166674
8Arginine biosynthesis_Homo sapiens_hsa002202.63098151
9Steroid biosynthesis_Homo sapiens_hsa001002.50557125
10Complement and coagulation cascades_Homo sapiens_hsa046102.38431567
11Gap junction_Homo sapiens_hsa045402.33401110
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31090778
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29696268
14Vascular smooth muscle contraction_Homo sapiens_hsa042702.27208870
15Tryptophan metabolism_Homo sapiens_hsa003802.27079909
16Fatty acid metabolism_Homo sapiens_hsa012122.25927315
17Peroxisome_Homo sapiens_hsa041462.14551628
18Propanoate metabolism_Homo sapiens_hsa006402.07503139
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00681059
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00548531
21PPAR signaling pathway_Homo sapiens_hsa033202.00484465
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98417141
23Serotonergic synapse_Homo sapiens_hsa047261.98207903
24Butanoate metabolism_Homo sapiens_hsa006501.93727407
25Arachidonic acid metabolism_Homo sapiens_hsa005901.92806009
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.91804367
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.89320964
28Chemical carcinogenesis_Homo sapiens_hsa052041.88390497
29Long-term depression_Homo sapiens_hsa047301.81452495
30Fatty acid biosynthesis_Homo sapiens_hsa000611.80087736
31beta-Alanine metabolism_Homo sapiens_hsa004101.79728234
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78680723
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76868000
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75953342
35Histidine metabolism_Homo sapiens_hsa003401.75274534
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74969236
37Circadian entrainment_Homo sapiens_hsa047131.74385806
38Bile secretion_Homo sapiens_hsa049761.69631745
39Alcoholism_Homo sapiens_hsa050341.67018353
40Retinol metabolism_Homo sapiens_hsa008301.64800143
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62866827
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60152049
43Vitamin digestion and absorption_Homo sapiens_hsa049771.57847664
44Fatty acid elongation_Homo sapiens_hsa000621.55334205
45Systemic lupus erythematosus_Homo sapiens_hsa053221.51971379
46Staphylococcus aureus infection_Homo sapiens_hsa051501.50549876
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39701413
48Collecting duct acid secretion_Homo sapiens_hsa049661.39555679
49Phenylalanine metabolism_Homo sapiens_hsa003601.27453319
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26825013
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26402572
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.23852741
53Starch and sucrose metabolism_Homo sapiens_hsa005001.21192743
54Tyrosine metabolism_Homo sapiens_hsa003501.20230377
55Sulfur metabolism_Homo sapiens_hsa009201.14540650
56Caffeine metabolism_Homo sapiens_hsa002321.13871264
57ABC transporters_Homo sapiens_hsa020101.13445880
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.13437393
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13384526
60Gastric acid secretion_Homo sapiens_hsa049711.09845378
61Rap1 signaling pathway_Homo sapiens_hsa040151.08118035
62Arginine and proline metabolism_Homo sapiens_hsa003301.03967132
63Focal adhesion_Homo sapiens_hsa045101.01886029
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01428603
65Fat digestion and absorption_Homo sapiens_hsa049751.01208255
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00015514
67Lysine degradation_Homo sapiens_hsa003100.99591954
68Pyruvate metabolism_Homo sapiens_hsa006200.98991248
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96995840
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96557923
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93924199
72Mismatch repair_Homo sapiens_hsa034300.91730063
73Melanoma_Homo sapiens_hsa052180.91057936
74Selenocompound metabolism_Homo sapiens_hsa004500.90589996
75Glycerolipid metabolism_Homo sapiens_hsa005610.87821507
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.85922041
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85885804
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85694407
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.84760310
80Vitamin B6 metabolism_Homo sapiens_hsa007500.82949902
81Sulfur relay system_Homo sapiens_hsa041220.81854052
82Sphingolipid metabolism_Homo sapiens_hsa006000.80247902
83Choline metabolism in cancer_Homo sapiens_hsa052310.78443723
84Chemokine signaling pathway_Homo sapiens_hsa040620.76158948
85Synaptic vesicle cycle_Homo sapiens_hsa047210.75644007
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73920244
87Glioma_Homo sapiens_hsa052140.73648214
88Ras signaling pathway_Homo sapiens_hsa040140.73594462
89Carbon metabolism_Homo sapiens_hsa012000.72266190
90Biosynthesis of amino acids_Homo sapiens_hsa012300.71240240
91Endometrial cancer_Homo sapiens_hsa052130.70416480
92Salivary secretion_Homo sapiens_hsa049700.69994600
93Dilated cardiomyopathy_Homo sapiens_hsa054140.69768863
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69390576
95Nicotine addiction_Homo sapiens_hsa050330.66348838
96Notch signaling pathway_Homo sapiens_hsa043300.63610051
97Amphetamine addiction_Homo sapiens_hsa050310.61885863
98Adherens junction_Homo sapiens_hsa045200.61111575
99Folate biosynthesis_Homo sapiens_hsa007900.61071931
100Cholinergic synapse_Homo sapiens_hsa047250.60802518
101Cocaine addiction_Homo sapiens_hsa050300.60723343
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60620864
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60037648
104Tight junction_Homo sapiens_hsa045300.59500952
105Endocytosis_Homo sapiens_hsa041440.58622109
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57511120
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57008432
108Olfactory transduction_Homo sapiens_hsa047400.56816251
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.55296633
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54729126
111Dopaminergic synapse_Homo sapiens_hsa047280.52777859
112Oxytocin signaling pathway_Homo sapiens_hsa049210.51890905
113Long-term potentiation_Homo sapiens_hsa047200.51176404
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50432894
115GABAergic synapse_Homo sapiens_hsa047270.49611535
116Hippo signaling pathway_Homo sapiens_hsa043900.47868072
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46320074
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45198838
119Hematopoietic cell lineage_Homo sapiens_hsa046400.44900297
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43737083
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43573155
122cAMP signaling pathway_Homo sapiens_hsa040240.43424503
123Linoleic acid metabolism_Homo sapiens_hsa005910.42444593
124Amoebiasis_Homo sapiens_hsa051460.42350263
125Metabolic pathways_Homo sapiens_hsa011000.41312062
126Renal cell carcinoma_Homo sapiens_hsa052110.41175970
127Ether lipid metabolism_Homo sapiens_hsa005650.40643656
128Basal cell carcinoma_Homo sapiens_hsa052170.39691325
129African trypanosomiasis_Homo sapiens_hsa051430.39110512
130Renin-angiotensin system_Homo sapiens_hsa046140.34949492
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34575106
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.29477540
133Ovarian steroidogenesis_Homo sapiens_hsa049130.27307070
134Glutamatergic synapse_Homo sapiens_hsa047240.27081589
135Insulin secretion_Homo sapiens_hsa049110.24024943
136Mineral absorption_Homo sapiens_hsa049780.23758157
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22134308
138One carbon pool by folate_Homo sapiens_hsa006700.20308760
139Pentose phosphate pathway_Homo sapiens_hsa000300.20268289
140Insulin resistance_Homo sapiens_hsa049310.19492153
141Glutathione metabolism_Homo sapiens_hsa004800.18870111
142Renin secretion_Homo sapiens_hsa049240.17953645
143Morphine addiction_Homo sapiens_hsa050320.17483566
144Glucagon signaling pathway_Homo sapiens_hsa049220.17389273
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17080111
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.15851526
147Pancreatic secretion_Homo sapiens_hsa049720.14110128
148Prion diseases_Homo sapiens_hsa050200.13753163
149Calcium signaling pathway_Homo sapiens_hsa040200.13438458
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12568066
151Fructose and mannose metabolism_Homo sapiens_hsa000510.12071434
152Circadian rhythm_Homo sapiens_hsa047100.11630874
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08053605
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07948103
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07312127
156Protein digestion and absorption_Homo sapiens_hsa049740.07281180
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.06708246
158Taste transduction_Homo sapiens_hsa047420.05549801
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04302017

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