FAM198B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.97540952
2collagen fibril organization (GO:0030199)5.66675576
3sequestering of extracellular ligand from receptor (GO:0035581)5.23824860
4cell adhesion mediated by integrin (GO:0033627)5.10783346
5protein heterotrimerization (GO:0070208)4.85018556
6plasma membrane repair (GO:0001778)4.69595593
7wound healing, spreading of epidermal cells (GO:0035313)4.67150327
8retina vasculature morphogenesis in camera-type eye (GO:0061299)4.62709819
9basement membrane organization (GO:0071711)4.52966562
10endodermal cell differentiation (GO:0035987)4.49700078
11substrate-dependent cell migration (GO:0006929)4.36812691
12membrane raft organization (GO:0031579)4.24068025
13axon extension involved in axon guidance (GO:0048846)4.15709767
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.15709767
15dermatan sulfate biosynthetic process (GO:0030208)4.06888820
16vascular endothelial growth factor signaling pathway (GO:0038084)4.06812574
17glucocorticoid biosynthetic process (GO:0006704)4.04777945
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.02477981
19skin morphogenesis (GO:0043589)3.98571872
20extracellular fibril organization (GO:0043206)3.86734572
21dermatan sulfate metabolic process (GO:0030205)3.75353443
22cardiac myofibril assembly (GO:0055003)3.73469996
23endocardial cushion development (GO:0003197)3.70328288
24collagen metabolic process (GO:0032963)3.70180192
25positive regulation of endothelial cell apoptotic process (GO:2000353)3.59928477
26detection of molecule of bacterial origin (GO:0032490)3.58152674
27collagen catabolic process (GO:0030574)3.57447366
28epithelial cell-cell adhesion (GO:0090136)3.56922584
29bone trabecula formation (GO:0060346)3.54932477
30fibril organization (GO:0097435)3.53720504
31endothelial cell morphogenesis (GO:0001886)3.53324084
32wound healing, spreading of cells (GO:0044319)3.47584743
33lymph vessel development (GO:0001945)3.47292309
34regulation of metalloenzyme activity (GO:0048552)3.45361549
35multicellular organismal macromolecule metabolic process (GO:0044259)3.44280205
36blood vessel maturation (GO:0001955)3.44138290
37negative regulation of nitric-oxide synthase activity (GO:0051001)3.40492561
38mesenchymal-epithelial cell signaling (GO:0060638)3.39883151
39substrate adhesion-dependent cell spreading (GO:0034446)3.36377367
40lymphangiogenesis (GO:0001946)3.33810485
41protein localization to cell surface (GO:0034394)3.28710548
42keratan sulfate catabolic process (GO:0042340)3.28039773
43cellular response to epinephrine stimulus (GO:0071872)3.25464237
44cell migration involved in sprouting angiogenesis (GO:0002042)3.25391125
45multicellular organismal catabolic process (GO:0044243)3.24048491
46glomerular basement membrane development (GO:0032836)3.23946484
47regulation of tight junction assembly (GO:2000810)3.22785341
48multicellular organismal metabolic process (GO:0044236)3.22666926
49stress fiber assembly (GO:0043149)3.22175001
50extracellular matrix disassembly (GO:0022617)3.20617213
51sarcomere organization (GO:0045214)3.20509348
52heart trabecula formation (GO:0060347)3.18595162
53regulation of SMAD protein import into nucleus (GO:0060390)3.17600471
54apoptotic cell clearance (GO:0043277)3.16193342
55glomerular filtration (GO:0003094)3.15656953
56low-density lipoprotein particle clearance (GO:0034383)3.15395582
57atrial septum morphogenesis (GO:0060413)3.14666152
58trabecula formation (GO:0060343)3.12130435
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.09566540
60negative regulation of fatty acid transport (GO:2000192)3.09114426
61positive regulation of receptor recycling (GO:0001921)3.06104130
62barbed-end actin filament capping (GO:0051016)3.05646243
63extracellular matrix assembly (GO:0085029)3.04549895
64hippo signaling (GO:0035329)3.03685940
65glucocorticoid metabolic process (GO:0008211)3.03387202
66myofibril assembly (GO:0030239)3.02852949
67positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.02163146
68regulation of macrophage chemotaxis (GO:0010758)3.00894723
69regulation of integrin-mediated signaling pathway (GO:2001044)2.99809090
70atrioventricular valve morphogenesis (GO:0003181)2.99193029
71endothelial cell proliferation (GO:0001935)2.98739961
72fibroblast migration (GO:0010761)2.95698233
73negative regulation of anoikis (GO:2000811)2.93736961
74venous blood vessel morphogenesis (GO:0048845)2.92032449
75regulation of cholesterol storage (GO:0010885)2.90993610
76regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.89385355
77extracellular regulation of signal transduction (GO:1900115)2.88659810
78extracellular negative regulation of signal transduction (GO:1900116)2.88659810
79extracellular matrix organization (GO:0030198)2.88656336
80negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.87904320
81extracellular structure organization (GO:0043062)2.87477473
82cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87432414
83protein localization to endosome (GO:0036010)2.86177595
84renal filtration (GO:0097205)2.84871046
85positive regulation of osteoblast proliferation (GO:0033690)2.83118971
86mammary gland development (GO:0030879)2.82885669
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.81334896
88ventricular cardiac muscle cell development (GO:0055015)2.78149014
89cell-substrate junction assembly (GO:0007044)2.76392593
90positive regulation of epithelial to mesenchymal transition (GO:0010718)2.75816360
91cellular response to thyroid hormone stimulus (GO:0097067)2.75613782
92insulin-like growth factor receptor signaling pathway (GO:0048009)2.73676330
93actin-myosin filament sliding (GO:0033275)2.73187286
94muscle filament sliding (GO:0030049)2.73187286
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71057552
96adhesion of symbiont to host (GO:0044406)2.69732147
97cell migration involved in heart development (GO:0060973)2.68433816
98peptidyl-proline hydroxylation (GO:0019511)2.67995632
99cell-matrix adhesion (GO:0007160)2.66888779
100actomyosin structure organization (GO:0031032)2.66544862
101regulation of apoptotic cell clearance (GO:2000425)2.66498034
102mesodermal cell differentiation (GO:0048333)2.66225507
103negative regulation of endothelial cell proliferation (GO:0001937)2.64664134
104vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.64125199
105cell-substrate adhesion (GO:0031589)2.64114863
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.63738496
107negative regulation of chondrocyte differentiation (GO:0032331)2.63040594
108endothelium development (GO:0003158)2.62399987
109adherens junction assembly (GO:0034333)2.62172072
110actin-mediated cell contraction (GO:0070252)2.61947170
111response to epinephrine (GO:0071871)2.61905250
112sprouting angiogenesis (GO:0002040)2.61139844
113negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.60946948
114positive regulation of macrophage cytokine production (GO:0060907)2.58944780
115cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.58370574
116C21-steroid hormone biosynthetic process (GO:0006700)2.58363600
117peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.56598770
118regulation of macrophage cytokine production (GO:0010935)2.56541604
119regulation of mononuclear cell migration (GO:0071675)2.54567687
120phagocytosis, recognition (GO:0006910)2.46023602
121positive regulation of extracellular matrix organization (GO:1903055)2.45612481
122positive regulation of cellular amide metabolic process (GO:0034250)2.45078947
123positive regulation of cholesterol efflux (GO:0010875)2.41423461
124angiogenesis involved in wound healing (GO:0060055)2.38897099
125detection of external biotic stimulus (GO:0098581)2.38174000
126pinocytosis (GO:0006907)2.32096818
127adhesion of symbiont to host cell (GO:0044650)2.30160981
128virion attachment to host cell (GO:0019062)2.30160981
129peptide catabolic process (GO:0043171)2.29779824
130glycosphingolipid catabolic process (GO:0046479)2.29209660
131ovulation from ovarian follicle (GO:0001542)2.28024535
132response to peptidoglycan (GO:0032494)2.23828965
133cortical actin cytoskeleton organization (GO:0030866)2.23568838
134hyaluronan catabolic process (GO:0030214)2.23173146
135negative regulation of erythrocyte differentiation (GO:0045647)2.22552857
136progesterone metabolic process (GO:0042448)2.22098943
137negative regulation of platelet activation (GO:0010544)2.21956307
138negative regulation of blood vessel endothelial cell migration (GO:0043537)2.21556347
139iron ion import (GO:0097286)2.21549839
140oligosaccharide catabolic process (GO:0009313)2.20537353
141regulation of chemokine-mediated signaling pathway (GO:0070099)2.19994940
142cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.19096080
143negative regulation of adherens junction organization (GO:1903392)2.18245791
144negative regulation of focal adhesion assembly (GO:0051895)2.18245791
145negative regulation of cell junction assembly (GO:1901889)2.18245791
146import into cell (GO:0098657)2.17381878
147cellular response to antibiotic (GO:0071236)2.16915014
148positive regulation of cholesterol transport (GO:0032376)2.16355106
149positive regulation of sterol transport (GO:0032373)2.16355106
150negative regulation of interleukin-12 production (GO:0032695)2.15885751
151response to laminar fluid shear stress (GO:0034616)2.14489771
152cellular extravasation (GO:0045123)2.13176092
153regulation of membrane protein ectodomain proteolysis (GO:0051043)2.12861326
154mannose metabolic process (GO:0006013)2.12502153
155regulation of extracellular matrix disassembly (GO:0010715)2.10908490
156complement activation, alternative pathway (GO:0006957)2.08626674
157detection of biotic stimulus (GO:0009595)2.07291191
158platelet-derived growth factor receptor signaling pathway (GO:0048008)2.06155607
159pathway-restricted SMAD protein phosphorylation (GO:0060389)2.05627103
160phagocytosis, engulfment (GO:0006911)2.05600095
161chondroitin sulfate catabolic process (GO:0030207)2.05551679
162C21-steroid hormone metabolic process (GO:0008207)2.05375748
163positive regulation of phagocytosis (GO:0050766)2.04577445
164response to thyroid hormone (GO:0097066)2.03662446
165positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.03569785
166positive regulation by symbiont of host defense response (GO:0052509)2.03156785
167modulation by symbiont of host defense response (GO:0052031)2.03156785
168modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.03156785
169modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.03156785
170positive regulation by organism of defense response of other organism involved in symbiotic interact2.03156785
171modulation by symbiont of host immune response (GO:0052553)2.03156785
172epithelial cell differentiation involved in prostate gland development (GO:0060742)2.02692744
173glycolipid catabolic process (GO:0019377)2.02622383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.27803355
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.47497176
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.27745927
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.46889579
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06993302
6EP300_21415370_ChIP-Seq_HL-1_Mouse3.06270585
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.00427344
8CJUN_26792858_Chip-Seq_BT549_Human2.98914085
9* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.96876726
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.77223579
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.70365942
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.63165377
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62010247
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60010847
15CLOCK_20551151_ChIP-Seq_293T_Human2.59127886
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.57315414
17BRD4_25478319_ChIP-Seq_HGPS_Human2.50502256
18* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.45554363
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43906915
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40910396
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.34895383
22NRF2_20460467_ChIP-Seq_MEFs_Mouse2.34895383
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.26738550
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.26334181
25GATA2_21666600_ChIP-Seq_HMVEC_Human2.24186262
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08806607
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08806607
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05914192
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02912542
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.00368031
31PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00345622
32MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.97503325
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.96844297
34TP53_16413492_ChIP-PET_HCT116_Human1.91140374
35TP53_18474530_ChIP-ChIP_U2OS_Human1.91019465
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89703761
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83987502
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82519502
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74268536
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72220636
41* IRF8_27001747_Chip-Seq_BMDM_Mouse1.72181485
42JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69767626
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.66152748
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65528498
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.62667994
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.62667994
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55936199
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52761860
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.49807368
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.49635407
51NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.47621810
52SOX2_20726797_ChIP-Seq_SW620_Human1.47140111
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46304458
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45273802
55ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39691111
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37994500
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37146919
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36526463
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.36258801
60* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35860146
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35688751
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32646875
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32626464
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.29151483
65* UBF1/2_26484160_Chip-Seq_HMECs_Human1.29135014
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27913740
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25936484
68GATA1_22025678_ChIP-Seq_K562_Human1.24957501
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23920246
70* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23481757
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22683835
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22336035
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22103870
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.22018197
75GATA4_21415370_ChIP-Seq_HL-1_Mouse1.21865708
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.20718662
77* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20558942
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18569573
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18270855
80SPI1_23127762_ChIP-Seq_K562_Human1.17795377
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.17630248
82TP53_23651856_ChIP-Seq_MEFs_Mouse1.16219482
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.15420462
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.15354174
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.11412749
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11280046
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11146796
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10950271
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08662140
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08662140
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08256114
92KDM2B_26808549_Chip-Seq_K562_Human1.07977477
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07705075
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07238879
95* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.05905755
96TP53_22127205_ChIP-Seq_IMR90_Human1.04124142
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.03375327
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.03326737
99* NFI_21473784_ChIP-Seq_ESCs_Mouse1.03306755
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.01900902
101* SA1_22415368_ChIP-Seq_MEFs_Mouse0.99644152
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99505748
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99276207
104* VDR_24787735_ChIP-Seq_THP-1_Human0.98890081
105ISL1_27105846_Chip-Seq_CPCs_Mouse0.98752554
106STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98628345
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.98344335
108MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98340521
109GATA1_19941826_ChIP-Seq_K562_Human0.98051025
110* TP63_23658742_ChIP-Seq_EP156T_Human0.97984008
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97717518
112BCAT_22108803_ChIP-Seq_LS180_Human0.97099914
113LXR_22292898_ChIP-Seq_THP-1_Human0.95871489
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.95389093
115* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95252339
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95034122
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93949260
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93280458
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92179928
120RUNX_20019798_ChIP-Seq_JUKART_Human0.91881601
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90725121
122SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90559249
123PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90171005
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87909839
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87593376
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87529202
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87321316
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87310798
129RXR_22108803_ChIP-Seq_LS180_Human0.87109066
130* ATF3_27146783_Chip-Seq_COLON_Human0.86998137
131VDR_24763502_ChIP-Seq_THP-1_Human0.86362875
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84490966
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.84471377
134* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84353328
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84232083
136SCL_19346495_ChIP-Seq_HPC-7_Human0.83976740
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83775652
138PU_27001747_Chip-Seq_BMDM_Mouse0.83540655
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83402998
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83009656
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82603925
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82556817
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82373448
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80029142
145AHR_22903824_ChIP-Seq_MCF-7_Human0.79518024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.40680709
2MP0005275_abnormal_skin_tensile4.49835811
3MP0003705_abnormal_hypodermis_morpholog4.43632817
4MP0005503_abnormal_tendon_morphology4.39827584
5MP0004272_abnormal_basement_membrane3.73707576
6MP0003279_aneurysm3.45934969
7MP0003724_increased_susceptibility_to3.15457512
8MP0003950_abnormal_plasma_membrane3.10255478
9MP0005058_abnormal_lysosome_morphology3.03490078
10MP0001958_emphysema2.98275695
11MP0005167_abnormal_blood-brain_barrier2.77585577
12MP0008004_abnormal_stomach_pH2.76336151
13MP0010368_abnormal_lymphatic_system2.74751429
14MP0005623_abnormal_meninges_morphology2.70475948
15MP0003303_peritoneal_inflammation2.48099495
16MP0003566_abnormal_cell_adhesion2.38636592
17MP0003828_pulmonary_edema2.38442415
18MP0005171_absent_coat_pigmentation2.15232679
19MP0001879_abnormal_lymphatic_vessel2.13684713
20MP0009384_cardiac_valve_regurgitation2.10390619
21MP0003045_fibrosis2.06255759
22MP0004084_abnormal_cardiac_muscle2.03383543
23MP0010352_gastrointestinal_tract_polyps1.96046328
24MP0009840_abnormal_foam_cell1.88776108
25MP0003690_abnormal_glial_cell1.83101881
26MP0003091_abnormal_cell_migration1.81593879
27MP0000767_abnormal_smooth_muscle1.78477346
28MP0005257_abnormal_intraocular_pressure1.77700950
29MP0009780_abnormal_chondrocyte_physiolo1.74928055
30MP0005508_abnormal_skeleton_morphology1.74792686
31MP0003172_abnormal_lysosome_physiology1.73383450
32MP0006054_spinal_hemorrhage1.72475898
33MP0000751_myopathy1.71050662
34MP0003075_altered_response_to1.69338763
35MP0001542_abnormal_bone_strength1.67902739
36MP0000604_amyloidosis1.67547124
37MP0006082_CNS_inflammation1.66328255
38MP0005330_cardiomyopathy1.61244213
39MP0002295_abnormal_pulmonary_circulatio1.59610880
40MP0005023_abnormal_wound_healing1.59033878
41MP0006138_congestive_heart_failure1.57609048
42MP0000749_muscle_degeneration1.52961451
43MP0000750_abnormal_muscle_regeneration1.48326827
44MP0002108_abnormal_muscle_morphology1.48163294
45MP0002060_abnormal_skin_morphology1.46702859
46MP0000465_gastrointestinal_hemorrhage1.43395162
47MP0003385_abnormal_body_wall1.42066650
48MP0003436_decreased_susceptibility_to1.41443167
49MP0000733_abnormal_muscle_development1.34082280
50MP0004858_abnormal_nervous_system1.31753302
51MP0002877_abnormal_melanocyte_morpholog1.29013502
52MP0002419_abnormal_innate_immunity1.27328430
53MP0009250_abnormal_appendicular_skeleto1.24294543
54MP0003329_amyloid_beta_deposits1.23913016
55MP0002972_abnormal_cardiac_muscle1.23735800
56MP0004087_abnormal_muscle_fiber1.20540151
57MP0002168_other_aberrant_phenotype1.20402177
58MP0004510_myositis1.20318474
59MP0001544_abnormal_cardiovascular_syste1.20010941
60MP0005385_cardiovascular_system_phenoty1.20010941
61MP0003941_abnormal_skin_development1.18976470
62MP0000013_abnormal_adipose_tissue1.17255815
63MP0005409_darkened_coat_color1.13719792
64MP0010630_abnormal_cardiac_muscle1.12529823
65MP0005595_abnormal_vascular_smooth1.10645582
66MP0008775_abnormal_heart_ventricle1.10197908
67MP0004215_abnormal_myocardial_fiber1.09955454
68MP0005620_abnormal_muscle_contractility1.08033933
69MP0005390_skeleton_phenotype1.07387734
70MP0003567_abnormal_fetal_cardiomyocyte1.04335258
71MP0002837_dystrophic_cardiac_calcinosis1.03979206
72MP0000920_abnormal_myelination1.03972972
73MP0002896_abnormal_bone_mineralization1.03070062
74MP0002128_abnormal_blood_circulation1.02826352
75MP0001243_abnormal_dermal_layer1.01249307
76MP0000343_altered_response_to0.99559472
77MP0010030_abnormal_orbit_morphology0.98854290
78MP0002133_abnormal_respiratory_system0.97239721
79MP0005388_respiratory_system_phenotype0.97239721
80MP0004036_abnormal_muscle_relaxation0.96894069
81MP0005166_decreased_susceptibility_to0.96250033
82MP0003191_abnormal_cellular_cholesterol0.94181221
83MP0001614_abnormal_blood_vessel0.93702615
84MP0002332_abnormal_exercise_endurance0.91722273
85MP0004130_abnormal_muscle_cell0.91560207
86MP0004883_abnormal_blood_vessel0.90364246
87MP0002925_abnormal_cardiovascular_devel0.87471212
88MP0001851_eye_inflammation0.86354942
89MP0005164_abnormal_response_to0.85914301
90MP0005165_increased_susceptibility_to0.84724370
91MP0001849_ear_inflammation0.84619677
92MP0004484_altered_response_of0.84352424
93MP0000759_abnormal_skeletal_muscle0.83824021
94MP0005369_muscle_phenotype0.83123689
95MP0002933_joint_inflammation0.83065386
96MP0000747_muscle_weakness0.83047407
97MP0005464_abnormal_platelet_physiology0.82494683
98MP0003448_altered_tumor_morphology0.81876708
99MP0009053_abnormal_anal_canal0.81295874
100MP0003795_abnormal_bone_structure0.80629684
101MP0008260_abnormal_autophagy0.79737801
102MP0009785_altered_susceptibility_to0.79017088
103MP0000266_abnormal_heart_morphology0.78970113
104MP0003634_abnormal_glial_cell0.78546747
105MP0000163_abnormal_cartilage_morphology0.76664305
106MP0003115_abnormal_respiratory_system0.76244384
107MP0005451_abnormal_body_composition0.76121567
108MP0001915_intracranial_hemorrhage0.75516950
109MP0001175_abnormal_lung_morphology0.75214959
110MP0001533_abnormal_skeleton_physiology0.74733286
111MP0001299_abnormal_eye_distance/0.74243258
112MP0000569_abnormal_digit_pigmentation0.74212373
113MP0002148_abnormal_hypersensitivity_rea0.74151724
114MP0002113_abnormal_skeleton_development0.73722779
115MP0002115_abnormal_skeleton_extremities0.73206924
116MP0000858_altered_metastatic_potential0.73054605
117MP0002106_abnormal_muscle_physiology0.71188245
118MP0000428_abnormal_craniofacial_morphol0.71043753
119MP0002282_abnormal_trachea_morphology0.70776236
120MP0002998_abnormal_bone_remodeling0.69048797
121MP0005025_abnormal_response_to0.68763218
122MP0002971_abnormal_brown_adipose0.68582112
123MP0004233_abnormal_muscle_weight0.68271122
124MP0005197_abnormal_uvea_morphology0.66994209
125MP0005387_immune_system_phenotype0.66932501
126MP0001790_abnormal_immune_system0.66932501
127MP0003300_gastrointestinal_ulcer0.66682053
128MP0000003_abnormal_adipose_tissue0.66551512
129MP0005670_abnormal_white_adipose0.66458537
130MP0003935_abnormal_craniofacial_develop0.65674772
131MP0003868_abnormal_feces_composition0.65356173
132MP0005666_abnormal_adipose_tissue0.63568852
133MP0004134_abnormal_chest_morphology0.63050086
134MP0005000_abnormal_immune_tolerance0.62969953
135MP0003755_abnormal_palate_morphology0.61880661
136MP0000516_abnormal_urinary_system0.61661515
137MP0005367_renal/urinary_system_phenotyp0.61661515
138MP0002127_abnormal_cardiovascular_syste0.59465288
139MP0000372_irregular_coat_pigmentation0.58048731
140MP0000249_abnormal_blood_vessel0.58027293

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.00193455
2Protrusio acetabuli (HP:0003179)7.79136713
3Aortic dissection (HP:0002647)5.03172931
4Cerebral aneurysm (HP:0004944)4.58543353
5Soft skin (HP:0000977)4.53391460
6Atrophic scars (HP:0001075)4.42119755
7Aortic aneurysm (HP:0004942)4.36031416
8Ankle contracture (HP:0006466)4.12854407
9Shallow orbits (HP:0000586)4.12806564
10Fragile skin (HP:0001030)4.05513409
11Abnormality of glycolipid metabolism (HP:0010969)3.98687880
12Abnormality of liposaccharide metabolism (HP:0010968)3.98687880
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.98687880
14Bladder diverticulum (HP:0000015)3.91042659
15Dilatation of the ascending aorta (HP:0005111)3.83380785
16Broad metatarsal (HP:0001783)3.75218651
17Increased connective tissue (HP:0009025)3.65596728
18Systemic lupus erythematosus (HP:0002725)3.63215881
19Spinal rigidity (HP:0003306)3.60328755
20Peritonitis (HP:0002586)3.53407062
21Spontaneous hematomas (HP:0007420)3.45569583
22Cervical subluxation (HP:0003308)3.42826535
23Dysostosis multiplex (HP:0000943)3.42207865
24Abnormality of dentin (HP:0010299)3.37358918
25Complement deficiency (HP:0004431)3.36536895
26Vertebral compression fractures (HP:0002953)3.16604529
27Wormian bones (HP:0002645)3.14735239
28Blue sclerae (HP:0000592)3.13483748
29Asymmetric septal hypertrophy (HP:0001670)3.13139300
30Genu recurvatum (HP:0002816)3.11299873
31Wrist flexion contracture (HP:0001239)3.08585268
32Mitral valve prolapse (HP:0001634)3.04475557
33Urinary glycosaminoglycan excretion (HP:0003541)3.04056319
34Mucopolysacchariduria (HP:0008155)3.04056319
35Type 1 muscle fiber predominance (HP:0003803)2.97940568
36Abnormality of complement system (HP:0005339)2.94381901
37Abnormality of polysaccharide metabolism (HP:0011012)2.92998378
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92998378
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92998378
40Recurrent gram-negative bacterial infections (HP:0005420)2.87413596
41Neonatal short-limb short stature (HP:0008921)2.80266961
42Lipoatrophy (HP:0100578)2.80143203
43Vascular tortuosity (HP:0004948)2.80083489
44Biconcave vertebral bodies (HP:0004586)2.79950741
45Follicular hyperkeratosis (HP:0007502)2.75605361
46Camptodactyly of toe (HP:0001836)2.75163853
47Glomerulonephritis (HP:0000099)2.73718224
48Overgrowth (HP:0001548)2.72170869
49Myocardial infarction (HP:0001658)2.68477681
50Neurofibrillary tangles (HP:0002185)2.64749580
51Aneurysm (HP:0002617)2.57516557
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.57136665
53Osteolytic defects of the hand bones (HP:0009699)2.57136665
54Mitral stenosis (HP:0001718)2.53863857
55Ulnar claw (HP:0001178)2.49740656
56Hyperextensible skin (HP:0000974)2.49669765
57Increased cerebral lipofuscin (HP:0011813)2.47469104
58Reduced subcutaneous adipose tissue (HP:0003758)2.46642561
59Abnormal delivery (HP:0001787)2.45221025
60Mitral regurgitation (HP:0001653)2.44889678
61Muscle fiber splitting (HP:0003555)2.44631289
62Bowel diverticulosis (HP:0005222)2.40462334
63Syringomyelia (HP:0003396)2.40397021
64Spinal cord lesions (HP:0100561)2.40397021
65Esophageal varix (HP:0002040)2.40210851
66Mildly elevated creatine phosphokinase (HP:0008180)2.35140298
67Pulmonary artery stenosis (HP:0004415)2.33126547
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32717592
69Sudden death (HP:0001699)2.32293682
70Amyloidosis (HP:0011034)2.31393877
71Short nail (HP:0001799)2.30839495
72Ovoid vertebral bodies (HP:0003300)2.30420457
73Polycythemia (HP:0001901)2.28818368
74Increased variability in muscle fiber diameter (HP:0003557)2.28087332
75Eczematoid dermatitis (HP:0000976)2.25565802
76Atrial fibrillation (HP:0005110)2.25318942
77Vacuolated lymphocytes (HP:0001922)2.23522819
78Joint laxity (HP:0001388)2.23261750
79Right ventricular cardiomyopathy (HP:0011663)2.22999309
80Round ear (HP:0100830)2.20826862
81Flexion contracture of toe (HP:0005830)2.20665830
82Joint contractures involving the joints of the feet (HP:0100492)2.20665830
83Abnormality of the acetabulum (HP:0003170)2.20185328
84Abnormality of macrophages (HP:0004311)2.17619178
85Difficulty climbing stairs (HP:0003551)2.15992494
86Conjunctival telangiectasia (HP:0000524)2.13937939
87Scapular winging (HP:0003691)2.13904958
88Glucose intolerance (HP:0000833)2.13753568
89Striae distensae (HP:0001065)2.11424013
90Thin bony cortex (HP:0002753)2.10846070
91Primary atrial arrhythmia (HP:0001692)2.10778725
92Increased density of long bones (HP:0006392)2.10312261
93Joint stiffness (HP:0001387)2.08858475
94Supraventricular arrhythmia (HP:0005115)2.07473963
95Cerebral inclusion bodies (HP:0100314)2.07249763
96Skin nodule (HP:0200036)2.05774344
97Broad ribs (HP:0000885)2.05329744
98Hypoplasia of the iris (HP:0007676)2.05128103
99Wide anterior fontanel (HP:0000260)2.04432060
100Abnormality of skeletal muscle fiber size (HP:0012084)2.04202499
101Spondylolisthesis (HP:0003302)2.02300268
102Venous abnormality (HP:0002624)2.02057312
103Subacute progressive viral hepatitis (HP:0006572)2.01680727
104Flared iliac wings (HP:0002869)2.01457901
105Ventricular tachycardia (HP:0004756)2.01056233
106Abnormality of the calf musculature (HP:0001430)1.98960954
107Loss of speech (HP:0002371)1.97875970
108Elbow flexion contracture (HP:0002987)1.97345851
109Supraventricular tachycardia (HP:0004755)1.95913223
110Segmental peripheral demyelination/remyelination (HP:0003481)1.93994023
111Nephritis (HP:0000123)1.93312024
112Upper limb muscle weakness (HP:0003484)1.91179417
113Axonal loss (HP:0003447)1.91161933
114Distal lower limb amyotrophy (HP:0008944)1.91132431
115Mesomelia (HP:0003027)1.90761206
116Distal lower limb muscle weakness (HP:0009053)1.90583197
117Hyporeflexia of lower limbs (HP:0002600)1.89872209
118Asymmetry of the thorax (HP:0001555)1.86191790
119Aortic regurgitation (HP:0001659)1.86170477
120Venous insufficiency (HP:0005293)1.84790339
121Slender build (HP:0001533)1.84490071
122Hematochezia (HP:0002573)1.84091355
123Abnormality of the anterior chamber (HP:0000593)1.83475459
124Arterial tortuosity (HP:0005116)1.82769557
125Nuclear cataract (HP:0100018)1.81412978
126Nonimmune hydrops fetalis (HP:0001790)1.77411519
127Hemorrhage of the eye (HP:0011885)1.77207771
128Delayed closure of the anterior fontanelle (HP:0001476)1.76856619
129Gingivitis (HP:0000230)1.76027142
130Aortic valve stenosis (HP:0001650)1.75450090
131Orchitis (HP:0100796)1.75409262
132Cupped ribs (HP:0000887)1.74979271
133Ectopia lentis (HP:0001083)1.71680788
134Breech presentation (HP:0001623)1.70998473
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.70979985
136Tetraparesis (HP:0002273)1.70489131
137Buphthalmos (HP:0000557)1.70458527
138Bell-shaped thorax (HP:0001591)1.69789907
139Osteopenia (HP:0000938)1.69682487
140Pulmonary hypertension (HP:0002092)1.69453529
141Delayed cranial suture closure (HP:0000270)1.67760694
142Tibial bowing (HP:0002982)1.67657767
143Coxa vara (HP:0002812)1.67589887
144Muscular dystrophy (HP:0003560)1.67547259
145Chondrocalcinosis (HP:0000934)1.67058518
146Infantile muscular hypotonia (HP:0008947)1.66800530
147Abnormality of the periventricular white matter (HP:0002518)1.66515622
148Abnormality of carpal bone ossification (HP:0006257)1.65684619
149Increased CSF protein (HP:0002922)1.65464978
150Abnormal ossification of hand bones (HP:0005921)1.64784266
151Purpura (HP:0000979)1.62863191
152Joint hemorrhage (HP:0005261)1.60277369
153Visceral angiomatosis (HP:0100761)1.59658778
154Myositis (HP:0100614)1.58340959
155Recurrent abscess formation (HP:0002722)1.56967425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.28292401
2DDR23.27986083
3TIE13.25495301
4DMPK3.10106713
5LATS12.72427862
6TRIB32.53038059
7TRPM72.49290822
8PDGFRA2.45901718
9STK38L2.35750994
10MYLK2.25448319
11AKT32.23560691
12EPHB22.21765210
13NEK92.19719298
14PKN22.18608634
15ZAK2.18128107
16LATS22.03032561
17STK242.00342283
18FER2.00019630
19PIK3CA1.98441856
20TGFBR21.93476796
21PTK2B1.89239144
22STK31.88612221
23PAK21.87053255
24BLK1.77062737
25FES1.71355992
26LIMK11.68928531
27PRPF4B1.63638398
28TESK11.60160182
29ERBB31.54739971
30KDR1.54729800
31NUAK11.52647297
32PAK31.47756278
33RIPK11.47635731
34TYK21.44867451
35PTK21.43594323
36NME21.42651510
37PAK41.42207324
38EPHA31.41967929
39FRK1.39776969
40ICK1.31597998
41OBSCN1.31316402
42ILK1.24421865
43ROCK11.21499279
44FGFR41.18598717
45PIM21.17862755
46PTK61.14297337
47MAP3K131.10386004
48BMX1.07817850
49TGFBR11.07081371
50ZAP701.05262417
51RIPK41.04776157
52MET1.03397983
53TAOK21.00476280
54PLK20.97668294
55PIK3CG0.97541734
56EPHB10.96844964
57FGR0.93516967
58IRAK30.92167486
59MAPK120.90994320
60NTRK10.90737930
61LRRK20.90410976
62PDGFRB0.89123606
63SGK30.89010133
64PDPK10.88098170
65CAMK1G0.87251413
66MAPK70.86956898
67SGK20.86675896
68CAMKK20.86625528
69MAP3K30.86141355
70MAP3K60.86047394
71RPS6KA40.85318273
72KSR20.83182704
73INSR0.82280775
74MKNK10.81725544
75JAK20.81212407
76MARK20.81081811
77PRKAA20.80922452
78JAK30.78829989
79MST1R0.76914312
80RPS6KA20.75713153
81PDK20.73886197
82EEF2K0.73095846
83CDC42BPA0.72902337
84MAP3K10.72181560
85ERN10.71207432
86MOS0.70843649
87PRKD10.70593827
88CSF1R0.70427741
89FGFR10.69940700
90SIK10.66561620
91MAP3K140.65260669
92TNK20.64723457
93GRK70.64183066
94CDK60.63601919
95MAP2K30.63271749
96SCYL20.62855108
97STK100.62460566
98MARK30.62286294
99CAMK1D0.62235900
100TBK10.61142574
101MTOR0.59691327
102FGFR30.59514481
103TYRO30.59248940
104SGK4940.58172420
105SGK2230.58172420
106PDK10.58159833
107HCK0.56724537
108DAPK30.56470412
109PRKG20.56203277
110WNK10.51188437
111ROCK20.51127329
112NLK0.50254330
113MAPKAPK30.49664193
114LMTK20.49461201
115MAP3K70.48094771
116YES10.47552333
117CSK0.47188454
118MELK0.46619303
119ABL10.45518745
120IGF1R0.45100214
121JAK10.44749676
122SRC0.44621191
123MAP3K20.44520792
124RPS6KC10.43994460
125RPS6KL10.43994460
126PDK40.43612818
127PDK30.43612818
128EPHA20.43540134
129PRKD30.42872579
130ARAF0.40989099
131MKNK20.40432013
132PRKCE0.40283665
133ABL20.39193938
134PRKD20.38082250
135KIT0.36141907
136PRKCH0.35107810
137EIF2AK20.35075425
138STK40.33879120
139RET0.33694951
140FLT30.33351189
141MAP3K50.32973731
142MAP2K10.29970144
143IRAK10.29855954
144PAK10.29030179
145TEC0.26941163
146ADRBK10.25621359
147MAPKAPK20.23390315

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.18099647
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.39709530
3Focal adhesion_Homo sapiens_hsa045103.38630105
4Dilated cardiomyopathy_Homo sapiens_hsa054143.20773469
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.89482792
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.75503691
7Other glycan degradation_Homo sapiens_hsa005112.67720215
8Viral myocarditis_Homo sapiens_hsa054162.62378795
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.57421732
10Adherens junction_Homo sapiens_hsa045202.52978553
11Proteoglycans in cancer_Homo sapiens_hsa052052.38962911
12Malaria_Homo sapiens_hsa051442.24794753
13Amoebiasis_Homo sapiens_hsa051462.22678188
14Staphylococcus aureus infection_Homo sapiens_hsa051502.19755989
15Small cell lung cancer_Homo sapiens_hsa052222.15892030
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.12856482
17Complement and coagulation cascades_Homo sapiens_hsa046101.96851451
18TGF-beta signaling pathway_Homo sapiens_hsa043501.90648913
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.74893341
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.73974596
21Protein digestion and absorption_Homo sapiens_hsa049741.73258226
22MicroRNAs in cancer_Homo sapiens_hsa052061.66150052
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.62448921
24Prion diseases_Homo sapiens_hsa050201.49416167
25Melanoma_Homo sapiens_hsa052181.45100042
26Hippo signaling pathway_Homo sapiens_hsa043901.42937595
27Shigellosis_Homo sapiens_hsa051311.36103773
28Tight junction_Homo sapiens_hsa045301.34608568
29Platelet activation_Homo sapiens_hsa046111.29357968
30Bladder cancer_Homo sapiens_hsa052191.27548644
31Toxoplasmosis_Homo sapiens_hsa051451.27134642
32p53 signaling pathway_Homo sapiens_hsa041151.24171049
33Rap1 signaling pathway_Homo sapiens_hsa040151.21287190
34Chronic myeloid leukemia_Homo sapiens_hsa052201.20100705
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17893340
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17864852
37Phagosome_Homo sapiens_hsa041451.17461535
38PPAR signaling pathway_Homo sapiens_hsa033201.10883180
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09981121
40Salmonella infection_Homo sapiens_hsa051321.08319898
41Pathways in cancer_Homo sapiens_hsa052001.05485027
42HIF-1 signaling pathway_Homo sapiens_hsa040661.03581063
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03004107
44Prostate cancer_Homo sapiens_hsa052150.95064895
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94917273
46Axon guidance_Homo sapiens_hsa043600.93494785
47TNF signaling pathway_Homo sapiens_hsa046680.90117019
48Renin secretion_Homo sapiens_hsa049240.88387512
49HTLV-I infection_Homo sapiens_hsa051660.85129788
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83610727
51Pancreatic cancer_Homo sapiens_hsa052120.83022510
52Estrogen signaling pathway_Homo sapiens_hsa049150.82766360
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.81692224
54Leishmaniasis_Homo sapiens_hsa051400.80898400
55Notch signaling pathway_Homo sapiens_hsa043300.80419843
56Glioma_Homo sapiens_hsa052140.80145053
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.77177816
58Mineral absorption_Homo sapiens_hsa049780.75357202
59Basal cell carcinoma_Homo sapiens_hsa052170.75258560
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74993618
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.74755872
62Ovarian steroidogenesis_Homo sapiens_hsa049130.74535568
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73866854
64Endocytosis_Homo sapiens_hsa041440.72801234
65Apoptosis_Homo sapiens_hsa042100.72193784
66Hedgehog signaling pathway_Homo sapiens_hsa043400.72115721
67Renal cell carcinoma_Homo sapiens_hsa052110.72083340
68Ras signaling pathway_Homo sapiens_hsa040140.71927267
69Prolactin signaling pathway_Homo sapiens_hsa049170.71735138
70Chemokine signaling pathway_Homo sapiens_hsa040620.70737482
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70549610
72Dorso-ventral axis formation_Homo sapiens_hsa043200.68330928
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67309518
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67186792
75Osteoclast differentiation_Homo sapiens_hsa043800.66717004
76B cell receptor signaling pathway_Homo sapiens_hsa046620.66082919
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64890066
78Lysosome_Homo sapiens_hsa041420.64816346
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64025370
80Hepatitis B_Homo sapiens_hsa051610.63125513
81Choline metabolism in cancer_Homo sapiens_hsa052310.62759145
82Viral carcinogenesis_Homo sapiens_hsa052030.62690213
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62234097
84Acute myeloid leukemia_Homo sapiens_hsa052210.62209787
85Fatty acid biosynthesis_Homo sapiens_hsa000610.61647519
86Wnt signaling pathway_Homo sapiens_hsa043100.60861844
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60707713
88Hematopoietic cell lineage_Homo sapiens_hsa046400.59691318
89Hepatitis C_Homo sapiens_hsa051600.59346164
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58421999
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.57366487
92Histidine metabolism_Homo sapiens_hsa003400.56443955
93Pertussis_Homo sapiens_hsa051330.56095379
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55728004
95Rheumatoid arthritis_Homo sapiens_hsa053230.55622436
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55205277
97Cardiac muscle contraction_Homo sapiens_hsa042600.54747777
98African trypanosomiasis_Homo sapiens_hsa051430.53589483
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.53519306
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53476354
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53362908
102Vibrio cholerae infection_Homo sapiens_hsa051100.53259964
103FoxO signaling pathway_Homo sapiens_hsa040680.53051407
104Tuberculosis_Homo sapiens_hsa051520.52149900
105Sphingolipid metabolism_Homo sapiens_hsa006000.50868814
106Melanogenesis_Homo sapiens_hsa049160.50822431
107Insulin resistance_Homo sapiens_hsa049310.50776185
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.50200845
109Influenza A_Homo sapiens_hsa051640.49746552
110Gap junction_Homo sapiens_hsa045400.49538641
111Colorectal cancer_Homo sapiens_hsa052100.49368494
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47426332
113Gastric acid secretion_Homo sapiens_hsa049710.46986132
114VEGF signaling pathway_Homo sapiens_hsa043700.46156627
115Renin-angiotensin system_Homo sapiens_hsa046140.45606809
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.45481941
117Endometrial cancer_Homo sapiens_hsa052130.45203926
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43254330
119mTOR signaling pathway_Homo sapiens_hsa041500.42434163
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42405157
121Cell cycle_Homo sapiens_hsa041100.41418957
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41012621
123MAPK signaling pathway_Homo sapiens_hsa040100.40120190
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38177995
125AMPK signaling pathway_Homo sapiens_hsa041520.37681020
126Insulin signaling pathway_Homo sapiens_hsa049100.37476302
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37192700
128Legionellosis_Homo sapiens_hsa051340.36588108
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33388021
130Thyroid cancer_Homo sapiens_hsa052160.33368405
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32391517
132Oxytocin signaling pathway_Homo sapiens_hsa049210.32355225
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.32269784
134GnRH signaling pathway_Homo sapiens_hsa049120.30303636

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