FAM19A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.17457333
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.97024373
3vocalization behavior (GO:0071625)5.64344592
4neuron cell-cell adhesion (GO:0007158)5.56098963
5presynaptic membrane organization (GO:0097090)5.53854431
6protein localization to synapse (GO:0035418)5.37540020
7postsynaptic membrane organization (GO:0001941)5.32674766
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.31098824
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.14803212
10neurotransmitter-gated ion channel clustering (GO:0072578)5.13162863
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.13045495
12regulation of glutamate receptor signaling pathway (GO:1900449)5.07600554
13glutamate receptor signaling pathway (GO:0007215)4.98322509
14positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.95344969
15synaptic vesicle exocytosis (GO:0016079)4.92489737
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91393728
17glutamate secretion (GO:0014047)4.69792318
18regulation of short-term neuronal synaptic plasticity (GO:0048172)4.69182211
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.67261705
20synaptic transmission, glutamatergic (GO:0035249)4.63056104
21regulation of synaptic vesicle exocytosis (GO:2000300)4.55735587
22neuronal action potential propagation (GO:0019227)4.47053891
23neuron-neuron synaptic transmission (GO:0007270)4.46810549
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.38129642
25cellular potassium ion homeostasis (GO:0030007)4.26545219
26positive regulation of dendritic spine development (GO:0060999)4.18168732
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.14386040
28neuron recognition (GO:0008038)4.13316305
29layer formation in cerebral cortex (GO:0021819)4.13186498
30regulation of synapse structural plasticity (GO:0051823)4.13092959
31sodium ion export (GO:0071436)4.10418372
32regulation of synaptic vesicle transport (GO:1902803)4.06881302
33startle response (GO:0001964)4.05993927
34pyrimidine nucleobase catabolic process (GO:0006208)4.02768669
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.98581370
36positive regulation of synapse maturation (GO:0090129)3.97033371
37regulation of postsynaptic membrane potential (GO:0060078)3.96786666
38long-term synaptic potentiation (GO:0060291)3.94050588
39positive regulation of neurotransmitter secretion (GO:0001956)3.90324331
40cerebral cortex radially oriented cell migration (GO:0021799)3.85421957
41central nervous system projection neuron axonogenesis (GO:0021952)3.80742382
42gamma-aminobutyric acid transport (GO:0015812)3.77732675
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71348317
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66796420
45cerebellar granule cell differentiation (GO:0021707)3.65780247
46response to histamine (GO:0034776)3.62953324
47exploration behavior (GO:0035640)3.61597613
48axonal fasciculation (GO:0007413)3.61290515
49locomotory exploration behavior (GO:0035641)3.59120533
50positive regulation of potassium ion transmembrane transport (GO:1901381)3.57626786
51mechanosensory behavior (GO:0007638)3.57165711
52regulation of synaptic plasticity (GO:0048167)3.56816231
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.55702622
54positive regulation of synapse assembly (GO:0051965)3.53819388
55L-amino acid import (GO:0043092)3.52640000
56nucleobase catabolic process (GO:0046113)3.52289179
57regulation of neuronal synaptic plasticity (GO:0048168)3.49308968
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49183975
59cochlea development (GO:0090102)3.47934185
60innervation (GO:0060384)3.47926837
61positive regulation of membrane potential (GO:0045838)3.45870508
62regulation of voltage-gated calcium channel activity (GO:1901385)3.44317034
63serotonin metabolic process (GO:0042428)3.44224011
64regulation of vesicle fusion (GO:0031338)3.42707243
65regulation of synapse maturation (GO:0090128)3.39381688
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38941256
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.35392249
68regulation of dendritic spine morphogenesis (GO:0061001)3.35343399
69regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.34348572
70neurotransmitter secretion (GO:0007269)3.34342806
71regulation of glutamate secretion (GO:0014048)3.34167620
72behavioral fear response (GO:0001662)3.33559252
73behavioral defense response (GO:0002209)3.33559252
74serotonin receptor signaling pathway (GO:0007210)3.31803088
75dendritic spine morphogenesis (GO:0060997)3.30528526
76regulation of neurotransmitter transport (GO:0051588)3.30358685
77negative regulation of dendrite morphogenesis (GO:0050774)3.29805863
78fear response (GO:0042596)3.28533840
79auditory behavior (GO:0031223)3.25439997
80regulation of neurotransmitter levels (GO:0001505)3.22523704
81synaptic vesicle endocytosis (GO:0048488)3.22345163
82regulation of dendritic spine development (GO:0060998)3.22023102
83membrane depolarization (GO:0051899)3.21758707
84regulation of axon regeneration (GO:0048679)3.20540279
85regulation of neuron projection regeneration (GO:0070570)3.20540279
86transmission of nerve impulse (GO:0019226)3.20494119
87behavioral response to cocaine (GO:0048148)3.16450788
88regulation of neurotransmitter secretion (GO:0046928)3.15763554
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15643501
90cerebellar Purkinje cell differentiation (GO:0021702)3.14721533
91regulation of synapse assembly (GO:0051963)3.14674630
92long-term memory (GO:0007616)3.13597560
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12737841
94synaptic vesicle maturation (GO:0016188)3.12398509
95synapse assembly (GO:0007416)3.12079364
96energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.09821981
97ATP hydrolysis coupled proton transport (GO:0015991)3.09821981
98positive regulation of neurotransmitter transport (GO:0051590)3.09505108
99regulation of Rac GTPase activity (GO:0032314)3.09183591
100positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.09171824
101negative regulation of dendrite development (GO:2000171)3.06622590
102response to nerve growth factor (GO:1990089)3.06474420
103cellular response to nerve growth factor stimulus (GO:1990090)3.06474420
104establishment of nucleus localization (GO:0040023)3.05578285
105dendrite morphogenesis (GO:0048813)3.05253484
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03969260
107transferrin transport (GO:0033572)3.03856237
108positive regulation of potassium ion transport (GO:0043268)3.03405767
109activation of protein kinase A activity (GO:0034199)3.03326406
110learning (GO:0007612)3.02944239
111adult walking behavior (GO:0007628)3.02943155
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99903009
113regulation of respiratory system process (GO:0044065)2.99712366
114neuromuscular synaptic transmission (GO:0007274)2.99439716
115regulation of dendrite morphogenesis (GO:0048814)2.98532005
116detection of calcium ion (GO:0005513)2.96435302
117amino acid import (GO:0043090)2.94999299
118primary amino compound metabolic process (GO:1901160)2.94668029
119positive regulation of dendritic spine morphogenesis (GO:0061003)2.94516433
120potassium ion import (GO:0010107)2.94347571
121membrane depolarization during action potential (GO:0086010)2.92568740
122synaptic transmission (GO:0007268)2.92117564
123sleep (GO:0030431)2.90371198
124membrane assembly (GO:0071709)2.90049721
125regulation of synaptic transmission (GO:0050804)2.89149966
126regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86980718
127neurotransmitter transport (GO:0006836)2.86668938
128positive regulation of synaptic transmission (GO:0050806)2.86661864
129dendrite development (GO:0016358)2.86460087
130ferric iron transport (GO:0015682)2.82909893
131trivalent inorganic cation transport (GO:0072512)2.82909893
132regulation of synapse organization (GO:0050807)2.81757991
133long term synaptic depression (GO:0060292)2.81455652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60310814
2* GBX2_23144817_ChIP-Seq_PC3_Human4.89337335
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02655948
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96809743
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91716727
6TAF15_26573619_Chip-Seq_HEK293_Human2.71593573
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62284774
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48567900
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42904847
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42407280
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42407280
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.41840137
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.39766346
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39078878
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38510126
16REST_21632747_ChIP-Seq_MESCs_Mouse2.36308569
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36142395
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32629521
19* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27230140
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17290082
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11660627
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11516875
23P300_19829295_ChIP-Seq_ESCs_Human2.06394387
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05092573
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05001545
26VDR_22108803_ChIP-Seq_LS180_Human2.01629901
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.96513424
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.96379532
29FUS_26573619_Chip-Seq_HEK293_Human1.92082801
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90253842
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89574884
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88462880
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.82417617
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81513422
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.80988502
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.78358076
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76161827
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.69972730
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69023496
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.68557648
41* SMAD3_21741376_ChIP-Seq_EPCs_Human1.66845226
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62452097
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62388631
44DROSHA_22980978_ChIP-Seq_HELA_Human1.62331889
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60691681
46AR_21572438_ChIP-Seq_LNCaP_Human1.59115325
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55574562
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55083132
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53378756
50AR_25329375_ChIP-Seq_VCAP_Human1.52243369
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49825873
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48624211
53IGF1R_20145208_ChIP-Seq_DFB_Human1.47183404
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46999088
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44479333
56RNF2_27304074_Chip-Seq_NSC_Mouse1.43553315
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41849444
58STAT3_23295773_ChIP-Seq_U87_Human1.38625178
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38236916
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37474787
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.35948112
62ZNF274_21170338_ChIP-Seq_K562_Hela1.33817384
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.33494546
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33482310
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29510428
66* TCF4_23295773_ChIP-Seq_U87_Human1.28741847
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.28246533
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26460414
69ER_23166858_ChIP-Seq_MCF-7_Human1.24243666
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24233084
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23775586
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.23467083
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.23009217
74TP53_18474530_ChIP-ChIP_U2OS_Human1.22413085
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.20019454
76* JUN_21703547_ChIP-Seq_K562_Human1.18529045
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18486160
78RUNX2_22187159_ChIP-Seq_PCA_Human1.18244007
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.17296680
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17228377
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16958293
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15478261
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14042636
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13970563
85P53_22387025_ChIP-Seq_ESCs_Mouse1.13798738
86BCAT_22108803_ChIP-Seq_LS180_Human1.13413263
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11847626
88EWS_26573619_Chip-Seq_HEK293_Human1.10295555
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09287520
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09065026
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08121711
92TP53_16413492_ChIP-PET_HCT116_Human1.06882995
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.06359004
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06295375
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06269556
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06269556
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05584496
98KDM2B_26808549_Chip-Seq_REH_Human1.03795244
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03691538
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03660852
101* AR_19668381_ChIP-Seq_PC3_Human1.03265662
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02306736
103SOX9_26525672_Chip-Seq_HEART_Mouse1.02030751
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01905286
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.00713788
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99943413
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99345113
108RING1B_27294783_Chip-Seq_ESCs_Mouse0.99335831
109SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99262104
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98937942
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98631693
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.96413289
113* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95420950
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.94784332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.88120093
2MP0004859_abnormal_synaptic_plasticity5.50404170
3MP0003635_abnormal_synaptic_transmissio3.84593790
4MP0004270_analgesia3.79882075
5MP0001968_abnormal_touch/_nociception3.38392564
6MP0009745_abnormal_behavioral_response3.30425555
7MP0002063_abnormal_learning/memory/cond3.27373810
8MP0002736_abnormal_nociception_after3.07603794
9MP0002064_seizures2.95315404
10MP0002735_abnormal_chemical_nociception2.89968347
11MP0002572_abnormal_emotion/affect_behav2.88265409
12MP0009046_muscle_twitch2.71253053
13MP0002272_abnormal_nervous_system2.55562880
14MP0001501_abnormal_sleep_pattern2.45917251
15MP0001440_abnormal_grooming_behavior2.35286887
16MP0002734_abnormal_mechanical_nocicepti2.31484209
17MP0001486_abnormal_startle_reflex2.26330910
18MP0002067_abnormal_sensory_capabilities2.19105356
19MP0001188_hyperpigmentation2.17345934
20MP0003787_abnormal_imprinting2.11451340
21MP0006276_abnormal_autonomic_nervous2.01751018
22MP0002837_dystrophic_cardiac_calcinosis2.00994605
23MP0003879_abnormal_hair_cell2.00102077
24MP0000778_abnormal_nervous_system1.86363673
25MP0009780_abnormal_chondrocyte_physiolo1.83465740
26MP0002638_abnormal_pupillary_reflex1.78876669
27MP0002733_abnormal_thermal_nociception1.78544559
28MP0002184_abnormal_innervation1.77566312
29MP0005646_abnormal_pituitary_gland1.74522618
30MP0002876_abnormal_thyroid_physiology1.73851652
31MP0001970_abnormal_pain_threshold1.71763716
32MP0005423_abnormal_somatic_nervous1.71396638
33MP0002557_abnormal_social/conspecific_i1.62311967
34MP0001529_abnormal_vocalization1.62012075
35MP0003329_amyloid_beta_deposits1.54097391
36MP0005386_behavior/neurological_phenoty1.48713030
37MP0004924_abnormal_behavior1.48713030
38MP0001984_abnormal_olfaction1.46644504
39MP0004858_abnormal_nervous_system1.43962994
40MP0000569_abnormal_digit_pigmentation1.43680001
41MP0005645_abnormal_hypothalamus_physiol1.41000237
42MP0005171_absent_coat_pigmentation1.39411010
43MP0008569_lethality_at_weaning1.31676546
44MP0000955_abnormal_spinal_cord1.31250107
45MP0001502_abnormal_circadian_rhythm1.30790378
46MP0001905_abnormal_dopamine_level1.30487855
47MP0004811_abnormal_neuron_physiology1.30014410
48MP0003122_maternal_imprinting1.29805100
49MP0002066_abnormal_motor_capabilities/c1.27599485
50MP0004145_abnormal_muscle_electrophysio1.24835936
51MP0004142_abnormal_muscle_tone1.23651041
52MP0002882_abnormal_neuron_morphology1.23442975
53MP0004742_abnormal_vestibular_system1.21197038
54MP0005409_darkened_coat_color1.14865203
55MP0010386_abnormal_urinary_bladder1.14330651
56MP0006292_abnormal_olfactory_placode1.13870121
57MP0000920_abnormal_myelination1.12663020
58MP0001963_abnormal_hearing_physiology1.11297155
59MP0003633_abnormal_nervous_system1.08717849
60MP0003136_yellow_coat_color1.05751918
61MP0002822_catalepsy1.04601989
62MP0004484_altered_response_of0.98480431
63MP0002653_abnormal_ependyma_morphology0.98269936
64MP0001485_abnormal_pinna_reflex0.96223399
65MP0003631_nervous_system_phenotype0.92382365
66MP0003690_abnormal_glial_cell0.92353272
67MP0002152_abnormal_brain_morphology0.91490737
68MP0000026_abnormal_inner_ear0.86330207
69MP0002229_neurodegeneration0.86251959
70MP0002909_abnormal_adrenal_gland0.86247412
71MP0004130_abnormal_muscle_cell0.85508482
72MP0005551_abnormal_eye_electrophysiolog0.82742510
73MP0004085_abnormal_heartbeat0.82511931
74MP0002069_abnormal_eating/drinking_beha0.82357906
75MP0001664_abnormal_digestion0.81943503
76MP0000751_myopathy0.81505816
77MP0000015_abnormal_ear_pigmentation0.81068307
78MP0004215_abnormal_myocardial_fiber0.79616162
79MP0005379_endocrine/exocrine_gland_phen0.79502461
80MP0000631_abnormal_neuroendocrine_gland0.78830906
81MP0008877_abnormal_DNA_methylation0.76520113
82MP0004885_abnormal_endolymph0.76188357
83MP0005535_abnormal_body_temperature0.75721589
84MP0002752_abnormal_somatic_nervous0.74931285
85MP0004147_increased_porphyrin_level0.72053414
86MP0002102_abnormal_ear_morphology0.71410693
87MP0002234_abnormal_pharynx_morphology0.69330169
88MP0008874_decreased_physiological_sensi0.68688567
89MP0003861_abnormal_nervous_system0.67759005
90MP0009379_abnormal_foot_pigmentation0.66407388
91MP0004043_abnormal_pH_regulation0.66257541
92MP0010769_abnormal_survival0.65679038
93MP0008872_abnormal_physiological_respon0.64460032
94MP0000013_abnormal_adipose_tissue0.63933292
95MP0001765_abnormal_ion_homeostasis0.63771672
96MP0010770_preweaning_lethality0.63153373
97MP0002082_postnatal_lethality0.63153373
98MP0010768_mortality/aging0.62122850
99MP0000604_amyloidosis0.61495971
100MP0003121_genomic_imprinting0.60846148
101MP0002249_abnormal_larynx_morphology0.59824759
102MP0002163_abnormal_gland_morphology0.57681968
103MP0003137_abnormal_impulse_conducting0.56552231
104MP0002751_abnormal_autonomic_nervous0.56325221
105MP0001943_abnormal_respiration0.55295384
106MP0003938_abnormal_ear_development0.53484963
107MP0003632_abnormal_nervous_system0.53152508
108MP0005499_abnormal_olfactory_system0.51602599
109MP0005394_taste/olfaction_phenotype0.51602599
110MP0003634_abnormal_glial_cell0.51568021
111MP0003956_abnormal_body_size0.50820407
112MP0001986_abnormal_taste_sensitivity0.49918483
113MP0008004_abnormal_stomach_pH0.49694148
114MP0005187_abnormal_penis_morphology0.49226474
115MP0000678_abnormal_parathyroid_gland0.48891907
116MP0001177_atelectasis0.48836398
117MP0003123_paternal_imprinting0.48518622
118MP0005595_abnormal_vascular_smooth0.48318730
119MP0005253_abnormal_eye_physiology0.45597578
120MP0002081_perinatal_lethality0.43670605
121MP0002873_normal_phenotype0.43171201
122MP0002169_no_abnormal_phenotype0.42348177

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.75898821
2Epileptic encephalopathy (HP:0200134)6.58219354
3Hyperventilation (HP:0002883)6.38747277
4Atonic seizures (HP:0010819)5.91365387
5Focal seizures (HP:0007359)5.38463039
6Febrile seizures (HP:0002373)5.35056091
7Absence seizures (HP:0002121)4.58148004
8Myokymia (HP:0002411)4.54020607
9Dialeptic seizures (HP:0011146)4.34802725
10Broad-based gait (HP:0002136)4.04499514
11Generalized tonic-clonic seizures (HP:0002069)3.79302833
12Ankle clonus (HP:0011448)3.77397333
13Visual hallucinations (HP:0002367)3.77102148
14Amblyopia (HP:0000646)3.69812110
15Progressive cerebellar ataxia (HP:0002073)3.61757482
16Spastic gait (HP:0002064)3.51146424
17Drooling (HP:0002307)3.34689288
18Excessive salivation (HP:0003781)3.34689288
19Protruding tongue (HP:0010808)3.34582649
20Epileptiform EEG discharges (HP:0011182)3.25058757
21Papilledema (HP:0001085)3.17839117
22Long nose (HP:0003189)3.15119679
23Urinary urgency (HP:0000012)3.10156295
24Abnormal hair whorl (HP:0010721)2.95000887
25Mutism (HP:0002300)2.90451759
26Lower limb muscle weakness (HP:0007340)2.89892118
27Gaze-evoked nystagmus (HP:0000640)2.88662879
28Intention tremor (HP:0002080)2.87703760
29Hemiplegia (HP:0002301)2.87221483
30Poor eye contact (HP:0000817)2.81832724
31Absent speech (HP:0001344)2.79140909
32Inability to walk (HP:0002540)2.78840948
33Conical tooth (HP:0000698)2.77550134
34Limb dystonia (HP:0002451)2.74672523
35Blue irides (HP:0000635)2.70378126
36Truncal ataxia (HP:0002078)2.66467231
37Gait imbalance (HP:0002141)2.64451927
38EEG with generalized epileptiform discharges (HP:0011198)2.62358396
39Postural instability (HP:0002172)2.57176070
40Abnormal eating behavior (HP:0100738)2.53807900
41Fair hair (HP:0002286)2.53508934
42Cerebral inclusion bodies (HP:0100314)2.52471623
43Torticollis (HP:0000473)2.52151403
44Medial flaring of the eyebrow (HP:0010747)2.51164683
45Dysdiadochokinesis (HP:0002075)2.48924464
46Acute necrotizing encephalopathy (HP:0006965)2.47828350
47Fetal akinesia sequence (HP:0001989)2.47537282
48Impaired vibration sensation in the lower limbs (HP:0002166)2.46272230
49Dysmetria (HP:0001310)2.43007621
50Diplopia (HP:0000651)2.42789000
51Abnormality of binocular vision (HP:0011514)2.42789000
52Spastic tetraparesis (HP:0001285)2.42113037
53Congenital primary aphakia (HP:0007707)2.41811250
54Thickened helices (HP:0000391)2.41333376
55Abnormal social behavior (HP:0012433)2.40208762
56Impaired social interactions (HP:0000735)2.40208762
57Anxiety (HP:0000739)2.39958782
58Amyotrophic lateral sclerosis (HP:0007354)2.38161957
59Abnormality of salivation (HP:0100755)2.35415849
60Abnormality of the lower motor neuron (HP:0002366)2.34302804
61Pheochromocytoma (HP:0002666)2.34033778
62Hypsarrhythmia (HP:0002521)2.33608274
63Cerebral hypomyelination (HP:0006808)2.32599335
64Abnormal EKG (HP:0003115)2.30576130
65Polyphagia (HP:0002591)2.27700878
66Abnormal mitochondria in muscle tissue (HP:0008316)2.24496646
67Progressive macrocephaly (HP:0004481)2.24375100
68Nephrogenic diabetes insipidus (HP:0009806)2.23227283
69Hemiparesis (HP:0001269)2.22035480
70Scanning speech (HP:0002168)2.21265757
71Status epilepticus (HP:0002133)2.20220232
72Delusions (HP:0000746)2.20103240
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.19679782
74Absent/shortened dynein arms (HP:0200106)2.19679782
75Termporal pattern (HP:0011008)2.19218344
76Insidious onset (HP:0003587)2.19218344
77Stereotypic behavior (HP:0000733)2.18040145
78Supranuclear gaze palsy (HP:0000605)2.18035974
79Generalized hypopigmentation of hair (HP:0011358)2.17962255
80Impaired smooth pursuit (HP:0007772)2.16554865
81Abnormality of ocular smooth pursuit (HP:0000617)2.16037676
82Action tremor (HP:0002345)2.15617458
83Intellectual disability, severe (HP:0010864)2.15209585
84Akinesia (HP:0002304)2.14432785
85Neurofibrillary tangles (HP:0002185)2.11922776
86Absent eyebrow (HP:0002223)2.10484780
87Neuroendocrine neoplasm (HP:0100634)2.10281885
88Tetraplegia (HP:0002445)2.09262559
89Megalencephaly (HP:0001355)2.08408553
90Genital tract atresia (HP:0001827)2.08329288
91Prolonged QT interval (HP:0001657)2.08296739
92Vaginal atresia (HP:0000148)2.07003024
93Clonus (HP:0002169)2.04311296
94Morphological abnormality of the pyramidal tract (HP:0002062)2.03414998
95Depression (HP:0000716)2.02397649
96Focal dystonia (HP:0004373)2.01369235
97Generalized myoclonic seizures (HP:0002123)2.00949234
98Progressive inability to walk (HP:0002505)2.00431824
99Gastroesophageal reflux (HP:0002020)2.00198062
100Heterochromia iridis (HP:0001100)1.99761981
101Syncope (HP:0001279)1.98962480
102Incomplete penetrance (HP:0003829)1.98377541
103Short tibia (HP:0005736)1.96867882
104Neuronal loss in central nervous system (HP:0002529)1.95862171
105Muscular hypotonia of the trunk (HP:0008936)1.95455912
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94102020
107Annular pancreas (HP:0001734)1.92479869
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.91624138
109Exotropia (HP:0000577)1.91265443
110Bradykinesia (HP:0002067)1.91053257
111Retinal dysplasia (HP:0007973)1.90994570
112Lissencephaly (HP:0001339)1.89414988
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.88476522
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88476522
115Hydroureter (HP:0000072)1.87513917
116Memory impairment (HP:0002354)1.84736434
117Spastic tetraplegia (HP:0002510)1.84437630
118Pachygyria (HP:0001302)1.83986379
119Dysautonomia (HP:0002459)1.83679823
120Decreased circulating renin level (HP:0003351)1.83482403
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82379653
122Abnormality of alanine metabolism (HP:0010916)1.82379653
123Hyperalaninemia (HP:0003348)1.82379653
124Oligodontia (HP:0000677)1.81830809
125Acute encephalopathy (HP:0006846)1.80456510
126Poor suck (HP:0002033)1.80354890
127Widely spaced teeth (HP:0000687)1.79893218
128Poor coordination (HP:0002370)1.79670850
129Hyperthyroidism (HP:0000836)1.79103742
130Lower limb amyotrophy (HP:0007210)1.78942525
131Narrow nasal bridge (HP:0000446)1.78641826
132Esotropia (HP:0000565)1.78320734
133Impaired vibratory sensation (HP:0002495)1.78260191
134Specific learning disability (HP:0001328)1.77379029
135Psychosis (HP:0000709)1.76856155
136Abnormality of the corticospinal tract (HP:0002492)1.74845081
137Mitochondrial inheritance (HP:0001427)1.74636074
138Inappropriate behavior (HP:0000719)1.73821416
139Neoplasm of the oral cavity (HP:0100649)1.73476178
140Clumsiness (HP:0002312)1.72731529
141Urinary bladder sphincter dysfunction (HP:0002839)1.71813082
142Preaxial foot polydactyly (HP:0001841)1.70759789
143Sleep apnea (HP:0010535)1.70581946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.99377457
2EPHA45.04339567
3NTRK34.80335864
4MAP2K72.95356541
5RIPK42.82757957
6MAP3K122.68467131
7MAP3K42.64121762
8PLK22.34589036
9CDK192.32717191
10DAPK22.18654739
11DAPK12.16238927
12RIPK12.08819498
13AKT32.05320895
14PRPF4B2.02262581
15MINK12.00459840
16TYRO31.86488266
17CCNB11.80210642
18BMPR21.77593209
19MAP2K41.68553336
20SIK31.66507016
21MAP3K91.61780269
22PNCK1.58910514
23TNIK1.56513718
24KSR11.56122222
25OXSR11.48976146
26MARK11.47753324
27NME11.44880239
28MAPK131.36545949
29CAMK2B1.25979741
30GRK51.25112078
31PRKCG1.25082648
32PTK2B1.24794728
33ARAF1.24546009
34CAMK2A1.22591135
35SIK21.20966216
36CDK51.12587615
37PAK61.12176209
38VRK11.09662888
39KSR21.08581821
40SGK21.08091313
41NTRK21.07086104
42TAOK31.04549808
43PINK11.03473942
44NTRK11.02862530
45SGK4940.97907649
46SGK2230.97907649
47BCR0.93916615
48CAMK40.92354652
49RAF10.89946321
50GRK70.87017039
51BRAF0.86478696
52FGR0.86092049
53LATS20.84652113
54FES0.84565027
55CAMKK20.84241123
56MAP3K130.80188523
57PRKCZ0.75773927
58TNK20.72556782
59PRKCE0.72522090
60SGK10.70706852
61CDC42BPA0.69516779
62FER0.68905143
63CDK180.67206084
64CAMKK10.66691909
65DYRK20.65797881
66PRKCH0.65283957
67FRK0.64287202
68TRIM280.63449874
69CDK150.58365865
70CAMK10.57767430
71CAMK2D0.57438917
72CDK140.56604614
73TGFBR20.55404898
74MAP2K60.54794035
75DYRK1A0.53721357
76SGK30.52982258
77MAPK150.52757528
78MARK20.52667665
79PDK30.49466329
80PDK40.49466329
81CDK11A0.48874210
82ADRBK20.48121527
83MAP2K10.47950690
84PAK30.47549337
85MAP3K20.47048516
86CDK30.45813886
87DMPK0.43408232
88MAPK120.43263858
89INSRR0.42700894
90MAPK70.42179923
91STK380.42143236
92UHMK10.41359794
93CAMK2G0.41330893
94PRKD30.40821518
95FYN0.40100865
96BMPR1B0.39725324
97ROCK20.39173232
98MAP4K20.39157098
99GRK60.38590777
100WNK30.38417494
101MAP3K110.37175145
102ADRBK10.37079052
103CAMK1G0.36852862
104MAP3K60.36582120
105PRKACA0.35608847
106MKNK20.34610050
107STK110.34451528
108PRKG10.34426325
109PIK3CA0.34395975
110MAPK100.34161071
111PRKCQ0.33854212
112CSNK1G20.33269088
113CSNK1D0.32830841
114NEK60.32810810
115TSSK60.32634081
116DAPK30.32138071
117PDGFRB0.32024120
118ROCK10.31250422
119MYLK0.31213872
120PKN10.29839471
121PRKCB0.29625612
122PDPK10.28951293
123STK390.28125721
124PRKCA0.27996390
125MAP3K10.27327348
126PDK10.27187960
127RET0.27151498
128PHKG20.26946710
129PHKG10.26946710
130RPS6KA30.26927183

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.85809331
2Long-term potentiation_Homo sapiens_hsa047203.21703883
3Synaptic vesicle cycle_Homo sapiens_hsa047213.12256581
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.08135946
5Circadian entrainment_Homo sapiens_hsa047132.89493182
6Amphetamine addiction_Homo sapiens_hsa050312.82216763
7Collecting duct acid secretion_Homo sapiens_hsa049662.68702140
8Glutamatergic synapse_Homo sapiens_hsa047242.67173156
9Morphine addiction_Homo sapiens_hsa050322.51587451
10GABAergic synapse_Homo sapiens_hsa047272.46065358
11Salivary secretion_Homo sapiens_hsa049702.33816638
12Taste transduction_Homo sapiens_hsa047422.30095695
13Olfactory transduction_Homo sapiens_hsa047402.22683437
14Dopaminergic synapse_Homo sapiens_hsa047282.15861119
15Serotonergic synapse_Homo sapiens_hsa047262.06500915
16Renin secretion_Homo sapiens_hsa049242.05409413
17Insulin secretion_Homo sapiens_hsa049111.89541406
18Long-term depression_Homo sapiens_hsa047301.86677894
19Calcium signaling pathway_Homo sapiens_hsa040201.83649815
20Oxytocin signaling pathway_Homo sapiens_hsa049211.66573399
21Vibrio cholerae infection_Homo sapiens_hsa051101.66430681
22Gastric acid secretion_Homo sapiens_hsa049711.64392189
23Oxidative phosphorylation_Homo sapiens_hsa001901.64302943
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62534744
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59604983
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54491697
27Cholinergic synapse_Homo sapiens_hsa047251.52099885
28Alzheimers disease_Homo sapiens_hsa050101.42637999
29Cocaine addiction_Homo sapiens_hsa050301.35052810
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31775332
31Phototransduction_Homo sapiens_hsa047441.25592383
32Gap junction_Homo sapiens_hsa045401.24010245
33GnRH signaling pathway_Homo sapiens_hsa049121.22900436
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21957253
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21665541
36Axon guidance_Homo sapiens_hsa043601.21439934
37cAMP signaling pathway_Homo sapiens_hsa040241.19490790
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15572180
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11727857
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06202378
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03601274
42Cardiac muscle contraction_Homo sapiens_hsa042601.02215887
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01052265
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.96952017
45Melanogenesis_Homo sapiens_hsa049160.95813054
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94320523
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93697922
48ErbB signaling pathway_Homo sapiens_hsa040120.91312719
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85742509
50Estrogen signaling pathway_Homo sapiens_hsa049150.85738047
51Glioma_Homo sapiens_hsa052140.84035986
52Parkinsons disease_Homo sapiens_hsa050120.80571980
53Pancreatic secretion_Homo sapiens_hsa049720.78339422
54Rheumatoid arthritis_Homo sapiens_hsa053230.77040572
55Huntingtons disease_Homo sapiens_hsa050160.76260621
56Type II diabetes mellitus_Homo sapiens_hsa049300.75197482
57African trypanosomiasis_Homo sapiens_hsa051430.72107884
58Glucagon signaling pathway_Homo sapiens_hsa049220.67350869
59MAPK signaling pathway_Homo sapiens_hsa040100.63991596
60Ras signaling pathway_Homo sapiens_hsa040140.63248227
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61097029
62Oocyte meiosis_Homo sapiens_hsa041140.60100467
63Circadian rhythm_Homo sapiens_hsa047100.57936736
64Choline metabolism in cancer_Homo sapiens_hsa052310.57134694
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56481858
66Dilated cardiomyopathy_Homo sapiens_hsa054140.56243878
67Bile secretion_Homo sapiens_hsa049760.55994877
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55704742
69Thyroid hormone synthesis_Homo sapiens_hsa049180.54534515
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52582260
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51612222
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51494921
73Phagosome_Homo sapiens_hsa041450.50629427
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49661346
75Dorso-ventral axis formation_Homo sapiens_hsa043200.48918063
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47939321
77Inositol phosphate metabolism_Homo sapiens_hsa005620.47828484
78Rap1 signaling pathway_Homo sapiens_hsa040150.44970964
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41895851
80VEGF signaling pathway_Homo sapiens_hsa043700.41784873
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41759739
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.41221227
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40128691
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39982518
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39816507
86Chemokine signaling pathway_Homo sapiens_hsa040620.39409931
87Vitamin B6 metabolism_Homo sapiens_hsa007500.38705349
88Wnt signaling pathway_Homo sapiens_hsa043100.37800065
89Colorectal cancer_Homo sapiens_hsa052100.36425674
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36410192
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35665078
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35231858
93Alcoholism_Homo sapiens_hsa050340.31807754
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30327612
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29971858
96Prion diseases_Homo sapiens_hsa050200.28582836
97Prolactin signaling pathway_Homo sapiens_hsa049170.28549728
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27711287
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27169840
100Fatty acid biosynthesis_Homo sapiens_hsa000610.26876407
101Endocytosis_Homo sapiens_hsa041440.26377303
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25917037
103Melanoma_Homo sapiens_hsa052180.25552205
104mTOR signaling pathway_Homo sapiens_hsa041500.24871345
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24612758
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.24428346
107T cell receptor signaling pathway_Homo sapiens_hsa046600.23920465
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23057221
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.22119206
110Regulation of autophagy_Homo sapiens_hsa041400.19957498
111Mineral absorption_Homo sapiens_hsa049780.19224006
112Endometrial cancer_Homo sapiens_hsa052130.19208049
113Type I diabetes mellitus_Homo sapiens_hsa049400.18400327
114Ovarian steroidogenesis_Homo sapiens_hsa049130.17384575
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17327427
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17014078
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16636201
118Insulin signaling pathway_Homo sapiens_hsa049100.15845898
119Pyruvate metabolism_Homo sapiens_hsa006200.15296396
120Renal cell carcinoma_Homo sapiens_hsa052110.12521666

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