FAM19A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of calcium ion transport into cytosol (GO:0010523)8.16570923
2peripheral nervous system neuron development (GO:0048935)7.82576761
3cell migration in hindbrain (GO:0021535)7.43778037
4neuronal action potential propagation (GO:0019227)6.20134748
5paraxial mesoderm development (GO:0048339)6.06636983
6negative regulation of hormone biosynthetic process (GO:0032353)5.90897357
7negative regulation of dendrite morphogenesis (GO:0050774)5.79146743
8regulation of meiosis I (GO:0060631)5.66878842
9protein K11-linked deubiquitination (GO:0035871)5.65307403
10negative regulation of cation channel activity (GO:2001258)5.36560274
11regulation of DNA methylation (GO:0044030)5.31274072
12retinal ganglion cell axon guidance (GO:0031290)5.25375505
13detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.19116077
14detection of temperature stimulus involved in sensory perception (GO:0050961)5.19116077
15negative regulation of hormone metabolic process (GO:0032351)5.17306272
16neuron fate specification (GO:0048665)4.88741060
17response to water (GO:0009415)4.85844662
18detection of temperature stimulus (GO:0016048)4.81520705
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.79005811
20serotonin receptor signaling pathway (GO:0007210)4.74772625
21negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.74013598
22retinal cone cell development (GO:0046549)4.70668755
23negative regulation of phosphoprotein phosphatase activity (GO:0032515)4.65549369
24neuronal action potential (GO:0019228)4.64674370
25potassium ion export (GO:0071435)4.59836379
26protein neddylation (GO:0045116)4.59798008
27membrane repolarization (GO:0086009)4.52434240
28innervation (GO:0060384)4.46557474
29negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.46443585
30chaperone-mediated protein transport (GO:0072321)4.45429409
31membrane budding (GO:0006900)4.42601404
32negative regulation of microtubule polymerization (GO:0031115)4.42053936
33protein maturation by protein folding (GO:0022417)4.29124454
34cellular response to nicotine (GO:0071316)4.25512370
35DNA methylation involved in gamete generation (GO:0043046)4.25079983
36meiotic cell cycle (GO:0051321)4.23941131
37piRNA metabolic process (GO:0034587)4.20040358
38behavioral response to pain (GO:0048266)4.18359770
39sequestering of actin monomers (GO:0042989)4.15895635
40regulation of acrosome reaction (GO:0060046)4.14568232
41regulation of female gonad development (GO:2000194)4.11437361
42alkaloid metabolic process (GO:0009820)4.10816451
43calcium-mediated signaling using intracellular calcium source (GO:0035584)4.08148853
44adenosine metabolic process (GO:0046085)4.07644693
45negative regulation of heart rate (GO:0010459)4.07477116
46regulation of steroid hormone biosynthetic process (GO:0090030)4.06170721
47cardiac myofibril assembly (GO:0055003)4.04332159
48regulation of cardioblast differentiation (GO:0051890)4.03801035
49eating behavior (GO:0042755)4.02868355
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.01011941
51protein polyglutamylation (GO:0018095)3.99914314
52negative regulation of dendrite development (GO:2000171)3.97835176
53regulation of transforming growth factor beta2 production (GO:0032909)3.91879242
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.91069907
55somite rostral/caudal axis specification (GO:0032525)3.89415200
56genitalia morphogenesis (GO:0035112)3.74686616
57aggressive behavior (GO:0002118)3.69589827
58detection of mechanical stimulus involved in sensory perception (GO:0050974)3.68350041
59membrane depolarization during action potential (GO:0086010)3.63410504
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.62134197
61negative regulation of norepinephrine secretion (GO:0010700)3.61875461
62positive regulation of cardiac muscle cell proliferation (GO:0060045)3.58155078
63regulation of hair follicle development (GO:0051797)3.54792711
64male genitalia development (GO:0030539)3.53808655
65glutamate secretion (GO:0014047)3.53372912
66establishment of mitochondrion localization (GO:0051654)3.52538068
67adenosine receptor signaling pathway (GO:0001973)3.51630968
68female gamete generation (GO:0007292)3.49628186
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47489385
70mating behavior (GO:0007617)3.46988669
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45624909
72cardiac right ventricle morphogenesis (GO:0003215)3.45565573
73response to pain (GO:0048265)3.44472122
74notochord development (GO:0030903)3.43475184
75protein localization to synapse (GO:0035418)3.40625930
76cullin deneddylation (GO:0010388)3.40400129
77cardiac chamber formation (GO:0003207)3.39228616
78positive regulation of cardiac muscle tissue development (GO:0055025)3.38069855
79negative regulation of DNA-dependent DNA replication (GO:2000104)3.35296428
80neuron cell-cell adhesion (GO:0007158)3.34552820
81CENP-A containing nucleosome assembly (GO:0034080)3.33706792
82regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.32310723
83myofibril assembly (GO:0030239)3.30137719
84positive regulation of cell size (GO:0045793)3.30069508
85negative regulation of ion transmembrane transporter activity (GO:0032413)3.27550993
86synaptic vesicle exocytosis (GO:0016079)3.27042446
87negative regulation of circadian rhythm (GO:0042754)3.26688210
88neuromuscular synaptic transmission (GO:0007274)3.26009830
89positive regulation of cardiac muscle tissue growth (GO:0055023)3.24118206
90neurofilament cytoskeleton organization (GO:0060052)3.24001084
91lipopolysaccharide biosynthetic process (GO:0009103)3.23631204
92positive regulation of hair follicle development (GO:0051798)3.23617499
93positive regulation of hair cycle (GO:0042635)3.23617499
94behavioral response to nicotine (GO:0035095)3.23405958
95negative regulation of protein autophosphorylation (GO:0031953)3.23228218
96regulation of sarcomere organization (GO:0060297)3.21078100
97chromatin remodeling at centromere (GO:0031055)3.20467892
98positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.18950825
99synaptic vesicle maturation (GO:0016188)3.17971650
100response to insecticide (GO:0017085)3.17807478
101synapsis (GO:0007129)3.16703028
102centriole replication (GO:0007099)3.16639869
103mitotic metaphase plate congression (GO:0007080)3.16048764
104protein deneddylation (GO:0000338)3.15475121
105protein localization to kinetochore (GO:0034501)3.14234060
106cerebellar Purkinje cell differentiation (GO:0021702)3.12322987
107response to redox state (GO:0051775)3.11754103
108outflow tract septum morphogenesis (GO:0003148)3.11303269
109nuclear pore organization (GO:0006999)3.10047832
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09591318
111enteric nervous system development (GO:0048484)3.08836626
112regulation of histone H3-K9 methylation (GO:0051570)3.06536203
113negative regulation of striated muscle cell apoptotic process (GO:0010664)3.06452298
114reproductive system development (GO:0061458)3.05062747
115primitive streak formation (GO:0090009)3.04914012
116regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.04219664
117atrial septum morphogenesis (GO:0060413)3.02893756
118peptidyl-arginine omega-N-methylation (GO:0035247)3.02667829
119regulation of glucocorticoid metabolic process (GO:0031943)3.02659496
120sarcoplasmic reticulum calcium ion transport (GO:0070296)3.01838314
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01570998
122positive regulation of heart growth (GO:0060421)3.01108884
123sensory perception of pain (GO:0019233)2.99575078
124mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.98490726
125negative regulation of homotypic cell-cell adhesion (GO:0034111)2.97941951
126proline transport (GO:0015824)2.97331652
127response to salt stress (GO:0009651)2.96145549
128ventricular cardiac muscle cell development (GO:0055015)2.95448816
129mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94926233
130regulation of neuron projection regeneration (GO:0070570)2.94718856
131regulation of axon regeneration (GO:0048679)2.94718856
132regulation of acyl-CoA biosynthetic process (GO:0050812)2.93900159
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92991818
134uterus development (GO:0060065)2.92159436
135synaptic transmission, dopaminergic (GO:0001963)2.91595056
136regulation of histone phosphorylation (GO:0033127)2.90516574
137action potential (GO:0001508)2.90220645
138regulation of cofactor metabolic process (GO:0051193)2.89742355
139regulation of coenzyme metabolic process (GO:0051196)2.89742355
140positive regulation of potassium ion transmembrane transport (GO:1901381)2.89476321
141ATP synthesis coupled proton transport (GO:0015986)2.88928421
142energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88928421
143cytidine metabolic process (GO:0046087)2.87061939
144cytidine catabolic process (GO:0006216)2.87061939
145cytidine deamination (GO:0009972)2.87061939
146regulation of hair cycle (GO:0042634)2.86476164
147regulation of synaptic vesicle exocytosis (GO:2000300)2.85964999
148gap junction assembly (GO:0016264)2.85884170
149response to vitamin E (GO:0033197)2.84538139
150sodium ion transmembrane transport (GO:0035725)2.83991627
151cellular component maintenance (GO:0043954)2.83844699
152regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83225539
153regulation of amyloid precursor protein catabolic process (GO:1902991)2.82288526
154metaphase plate congression (GO:0051310)2.82128615
155negative regulation of transporter activity (GO:0032410)2.81963982
156mitotic chromosome condensation (GO:0007076)2.81367746
157regulation of posttranscriptional gene silencing (GO:0060147)2.80514241
158regulation of gene silencing by miRNA (GO:0060964)2.80514241
159regulation of gene silencing by RNA (GO:0060966)2.80514241
160axon cargo transport (GO:0008088)2.79038083
161establishment of integrated proviral latency (GO:0075713)2.78678065
162heart valve formation (GO:0003188)2.78623296
163cell communication involved in cardiac conduction (GO:0086065)2.78317907
164oocyte development (GO:0048599)2.77310856
165mesenchyme morphogenesis (GO:0072132)2.77277177
166regulation of cardiac muscle cell proliferation (GO:0060043)2.75372694
167gene silencing by RNA (GO:0031047)2.74772135
168negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.74484284
169regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74455419
170membrane assembly (GO:0071709)2.74156944
171neuromuscular process controlling posture (GO:0050884)2.73811274
172positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73347389
173histone arginine methylation (GO:0034969)2.73169354
174spindle assembly involved in mitosis (GO:0090307)2.71725717
175cell communication by electrical coupling (GO:0010644)2.70767913
176histone exchange (GO:0043486)2.70023069
177cardiac muscle cell development (GO:0055013)2.69652854
178protein K48-linked deubiquitination (GO:0071108)2.69497201
179positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.69368195
180positive regulation of DNA-dependent DNA replication (GO:2000105)2.68706548
181SMAD protein signal transduction (GO:0060395)2.68268397
182endocardial cushion morphogenesis (GO:0003203)2.66870637
183gastrulation with mouth forming second (GO:0001702)2.66161187
184regulation of sulfur metabolic process (GO:0042762)2.65841374
185nodal signaling pathway (GO:0038092)2.65595021
186regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.63678869
187protein localization to chromosome, centromeric region (GO:0071459)2.60690129
188DNA double-strand break processing (GO:0000729)2.58570372
189regulation of cardiac muscle cell apoptotic process (GO:0010665)2.57014860
190high-density lipoprotein particle remodeling (GO:0034375)2.56432446
191regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55007095
192relaxation of cardiac muscle (GO:0055119)2.54237219
193negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.54069805
194cardiac cell development (GO:0055006)2.52113267
195regulation of cardiac muscle tissue development (GO:0055024)2.52051936
196positive regulation of chromosome segregation (GO:0051984)2.51518603
197lymphangiogenesis (GO:0001946)2.51371436
198multicellular organism reproduction (GO:0032504)2.50360261
199cardiac muscle hypertrophy (GO:0003300)2.48074219
200embryonic foregut morphogenesis (GO:0048617)2.47590170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.91431408
2ZNF263_19887448_ChIP-Seq_K562_Human3.89625483
3TAF15_26573619_Chip-Seq_HEK293_Human3.67723815
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.20155760
5EZH2_22144423_ChIP-Seq_EOC_Human3.17404633
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15823643
7JARID2_20075857_ChIP-Seq_MESCs_Mouse3.06799833
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85400298
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78555402
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72347411
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.70264488
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68178542
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65274990
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65274990
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63943345
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.57677778
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.57668289
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.52671195
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27764319
20REST_21632747_ChIP-Seq_MESCs_Mouse2.21868933
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19595204
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.18050581
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17114115
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.14088425
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.14088425
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.14088425
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13954514
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08236551
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.06605888
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.01963259
31FUS_26573619_Chip-Seq_HEK293_Human2.01226845
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.96186557
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94154083
34E2F7_22180533_ChIP-Seq_HELA_Human1.92890363
35IGF1R_20145208_ChIP-Seq_DFB_Human1.92087241
36EWS_26573619_Chip-Seq_HEK293_Human1.89426005
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89352290
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89047165
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87727657
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86362046
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84197627
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.83737987
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82142701
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80905932
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80122045
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78302995
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72595280
48CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.70889346
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69311777
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.68699379
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66574329
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65999769
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.65384266
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.64254554
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56603973
56FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.54626118
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.54006877
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.53805142
59RNF2_27304074_Chip-Seq_NSC_Mouse1.53508495
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51553765
61AR_21909140_ChIP-Seq_LNCAP_Human1.50351082
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.49969054
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49814470
64* P300_19829295_ChIP-Seq_ESCs_Human1.49716295
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47890882
66BCAT_22108803_ChIP-Seq_LS180_Human1.46313655
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45545549
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45253836
69TCF4_23295773_ChIP-Seq_U87_Human1.44991230
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42706092
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41731674
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40847446
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40667421
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.39396424
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.37601398
76* STAT3_23295773_ChIP-Seq_U87_Human1.37260730
77* GBX2_23144817_ChIP-Seq_PC3_Human1.37068008
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36536510
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36446071
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35863708
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.35090976
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34647890
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34096875
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33470296
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.31950590
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.31806358
87SMAD4_21799915_ChIP-Seq_A2780_Human1.31548313
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28841084
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.28492664
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.28047980
91VDR_22108803_ChIP-Seq_LS180_Human1.27477895
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.26890111
93ZNF274_21170338_ChIP-Seq_K562_Hela1.25598324
94* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25394305
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21766786
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.20696182
97TCF4_22108803_ChIP-Seq_LS180_Human1.20311978
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18852180
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18141356
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17528801
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16711356
102* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16248378
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15965786
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15415962
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15084322
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14996533
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.14332986
108CTCF_27219007_Chip-Seq_Bcells_Human1.13883238
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12074445
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12074445
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11763315
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11610775
113RUNX2_22187159_ChIP-Seq_PCA_Human1.10318942
114TP53_16413492_ChIP-PET_HCT116_Human1.08726251
115RARB_27405468_Chip-Seq_BRAIN_Mouse1.07935120
116IRF1_19129219_ChIP-ChIP_H3396_Human1.07556877
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.07415010
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.07323390
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.06827511
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05808255
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05619053
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.05154183
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04846889
124* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04220622
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03265879
126ER_23166858_ChIP-Seq_MCF-7_Human1.03017257
127TTF2_22483619_ChIP-Seq_HELA_Human1.02808425
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01375063
129ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00710588
130* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00655717
131* CBP_20019798_ChIP-Seq_JUKART_Human1.00655717
132SOX9_26525672_Chip-Seq_HEART_Mouse1.00013302
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99765305
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99417100
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99311039
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98988682
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98986942
138CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98459018
139* AR_25329375_ChIP-Seq_VCAP_Human0.97308648
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.97040973
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96735140
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96406766
143* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95565322
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.95475137
145CDX2_22108803_ChIP-Seq_LS180_Human0.95321891
146FLI1_21867929_ChIP-Seq_TH2_Mouse0.94888673
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94094379
148* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93724718
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93471052
150ETS1_20019798_ChIP-Seq_JURKAT_Human0.93170469
151MYC_18555785_ChIP-Seq_MESCs_Mouse0.92596564
152KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92545996
153MYC_18940864_ChIP-ChIP_HL60_Human0.92244406
154SOX2_19829295_ChIP-Seq_ESCs_Human0.92223638
155NANOG_19829295_ChIP-Seq_ESCs_Human0.92223638
156AHR_22903824_ChIP-Seq_MCF-7_Human0.92170926
157CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91955905
158* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91456280
159SOX2_21211035_ChIP-Seq_LN229_Gbm0.91027153
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.90799328
161ARNT_22903824_ChIP-Seq_MCF-7_Human0.90563068
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90437119
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89975474
164AR_21572438_ChIP-Seq_LNCaP_Human0.89570467
165PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.88567537
166SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86227883
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.84874618
168PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83797024
169JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82390679
170ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82138126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.31574096
2MP0001968_abnormal_touch/_nociception5.24141933
3MP0003941_abnormal_skin_development5.17775237
4MP0004270_analgesia5.10255893
5MP0002736_abnormal_nociception_after4.23264692
6MP0002734_abnormal_mechanical_nocicepti4.07551585
7MP0003718_maternal_effect3.98312391
8MP0004858_abnormal_nervous_system3.97979580
9MP0002733_abnormal_thermal_nociception3.92147746
10MP0002102_abnormal_ear_morphology3.57980421
11MP0001986_abnormal_taste_sensitivity3.54426275
12MP0001970_abnormal_pain_threshold3.32232897
13MP0003136_yellow_coat_color3.13644264
14MP0004859_abnormal_synaptic_plasticity3.13464550
15MP0003880_abnormal_central_pattern3.03365619
16MP0008877_abnormal_DNA_methylation2.92458114
17MP0006276_abnormal_autonomic_nervous2.86814754
18MP0002751_abnormal_autonomic_nervous2.82344823
19MP0002184_abnormal_innervation2.79998412
20MP0005083_abnormal_biliary_tract2.75303234
21MP0008260_abnormal_autophagy2.70761928
22MP0002138_abnormal_hepatobiliary_system2.31982230
23MP0003567_abnormal_fetal_cardiomyocyte2.21247123
24MP0006292_abnormal_olfactory_placode2.01244950
25MP0002272_abnormal_nervous_system1.99902122
26MP0010386_abnormal_urinary_bladder1.99878369
27MP0001270_distended_abdomen1.95141745
28MP0002067_abnormal_sensory_capabilities1.89355622
29MP0003635_abnormal_synaptic_transmissio1.82261970
30MP0000955_abnormal_spinal_cord1.81611195
31MP0003195_calcinosis1.78819204
32MP0001905_abnormal_dopamine_level1.78587539
33MP0003119_abnormal_digestive_system1.75553774
34MP0004215_abnormal_myocardial_fiber1.75254819
35MP0005395_other_phenotype1.73207288
36MP0002064_seizures1.72325221
37MP0004811_abnormal_neuron_physiology1.67304764
38MP0005171_absent_coat_pigmentation1.65074006
39MP0001440_abnormal_grooming_behavior1.62642884
40MP0004084_abnormal_cardiac_muscle1.60848448
41MP0003937_abnormal_limbs/digits/tail_de1.60238788
42MP0001293_anophthalmia1.58648609
43MP0002254_reproductive_system_inflammat1.56423344
44MP0004142_abnormal_muscle_tone1.56063202
45MP0003693_abnormal_embryo_hatching1.52011540
46MP0000778_abnormal_nervous_system1.51824434
47MP0002139_abnormal_hepatobiliary_system1.51683639
48MP0000751_myopathy1.49764664
49MP0000538_abnormal_urinary_bladder1.49169004
50MP0004957_abnormal_blastocyst_morpholog1.48078827
51MP0000749_muscle_degeneration1.45622599
52MP0005248_abnormal_Harderian_gland1.45282825
53MP0005423_abnormal_somatic_nervous1.44992874
54MP0003646_muscle_fatigue1.44675758
55MP0001529_abnormal_vocalization1.44625626
56MP0008057_abnormal_DNA_replication1.43549479
57MP0010094_abnormal_chromosome_stability1.42738125
58MP0008961_abnormal_basal_metabolism1.41692582
59MP0002233_abnormal_nose_morphology1.40586700
60MP0005085_abnormal_gallbladder_physiolo1.39902536
61MP0001730_embryonic_growth_arrest1.37691678
62MP0005551_abnormal_eye_electrophysiolog1.34754143
63MP0005380_embryogenesis_phenotype1.34642167
64MP0001672_abnormal_embryogenesis/_devel1.34642167
65MP0002882_abnormal_neuron_morphology1.33890931
66MP0002063_abnormal_learning/memory/cond1.33169820
67MP0009046_muscle_twitch1.32906463
68MP0003077_abnormal_cell_cycle1.31870081
69MP0002127_abnormal_cardiovascular_syste1.31166202
70MP0003183_abnormal_peptide_metabolism1.30431369
71MP0009745_abnormal_behavioral_response1.27492652
72MP0009840_abnormal_foam_cell1.27312246
73MP0002697_abnormal_eye_size1.25900422
74MP0002210_abnormal_sex_determination1.23719815
75MP0002638_abnormal_pupillary_reflex1.22301788
76MP0002752_abnormal_somatic_nervous1.21470136
77MP0005499_abnormal_olfactory_system1.20919457
78MP0005394_taste/olfaction_phenotype1.20919457
79MP0002572_abnormal_emotion/affect_behav1.19857721
80MP0005647_abnormal_sex_gland1.17965438
81MP0004145_abnormal_muscle_electrophysio1.16545974
82MP0008932_abnormal_embryonic_tissue1.16127910
83MP0003984_embryonic_growth_retardation1.13762547
84MP0002084_abnormal_developmental_patter1.13240499
85MP0001929_abnormal_gametogenesis1.13175158
86MP0002234_abnormal_pharynx_morphology1.12759954
87MP0000653_abnormal_sex_gland1.12022171
88MP0002088_abnormal_embryonic_growth/wei1.11076963
89MP0003329_amyloid_beta_deposits1.08327743
90MP0003111_abnormal_nucleus_morphology1.05169150
91MP0003699_abnormal_female_reproductive1.02766932
92MP0003656_abnormal_erythrocyte_physiolo1.00704925
93MP0006072_abnormal_retinal_apoptosis1.00609614
94MP0008058_abnormal_DNA_repair1.00547710
95MP0001145_abnormal_male_reproductive1.00442596
96MP0002163_abnormal_gland_morphology1.00222448
97MP0003950_abnormal_plasma_membrane0.99378866
98MP0006054_spinal_hemorrhage0.98933514
99MP0002090_abnormal_vision0.98778472
100MP0000427_abnormal_hair_cycle0.97905082
101MP0001286_abnormal_eye_development0.97432942
102MP0004036_abnormal_muscle_relaxation0.97362010
103MP0005389_reproductive_system_phenotype0.97327666
104MP0000747_muscle_weakness0.97074316
105MP0002938_white_spotting0.96149321
106MP0003121_genomic_imprinting0.95826437
107MP0003634_abnormal_glial_cell0.95046734
108MP0002229_neurodegeneration0.93489973
109MP0002160_abnormal_reproductive_system0.93067952
110MP0002066_abnormal_motor_capabilities/c0.93040727
111MP0001299_abnormal_eye_distance/0.91519793
112MP0001664_abnormal_digestion0.91209349
113MP0009672_abnormal_birth_weight0.90870214
114MP0004924_abnormal_behavior0.90712345
115MP0005386_behavior/neurological_phenoty0.90712345
116MP0001697_abnormal_embryo_size0.89729212
117MP0000516_abnormal_urinary_system0.88583996
118MP0005367_renal/urinary_system_phenotyp0.88583996
119MP0001119_abnormal_female_reproductive0.88341650
120MP0003935_abnormal_craniofacial_develop0.88126344
121MP0000631_abnormal_neuroendocrine_gland0.87510977
122MP0000639_abnormal_adrenal_gland0.86476143
123MP0002653_abnormal_ependyma_morphology0.84302223
124MP0010307_abnormal_tumor_latency0.84179825
125MP0009379_abnormal_foot_pigmentation0.83729528
126MP0002085_abnormal_embryonic_tissue0.83115022
127MP0003385_abnormal_body_wall0.81626132
128MP0005253_abnormal_eye_physiology0.80583435
129MP0000537_abnormal_urethra_morphology0.79821242
130MP0002822_catalepsy0.79251055
131MP0002161_abnormal_fertility/fecundity0.79110970
132MP0001348_abnormal_lacrimal_gland0.78267215
133MP0004510_myositis0.78089040
134MP0008775_abnormal_heart_ventricle0.77768567
135MP0003698_abnormal_male_reproductive0.77422257
136MP0002557_abnormal_social/conspecific_i0.76957161
137MP0001486_abnormal_startle_reflex0.76282090
138MP0003878_abnormal_ear_physiology0.75891867
139MP0005377_hearing/vestibular/ear_phenot0.75891867
140MP0001324_abnormal_eye_pigmentation0.75387256
141MP0010352_gastrointestinal_tract_polyps0.75145127
142MP0001984_abnormal_olfaction0.75022168
143MP0002837_dystrophic_cardiac_calcinosis0.72986252
144MP0010030_abnormal_orbit_morphology0.72584724
145MP0008569_lethality_at_weaning0.70916782
146MP0005620_abnormal_muscle_contractility0.70136886
147MP0001963_abnormal_hearing_physiology0.69252716
148MP0000534_abnormal_ureter_morphology0.68840946
149MP0004742_abnormal_vestibular_system0.64854667
150MP0003315_abnormal_perineum_morphology0.61605182
151MP0001501_abnormal_sleep_pattern0.60637762
152MP0002152_abnormal_brain_morphology0.60199498
153MP0008874_decreased_physiological_sensi0.59824157
154MP0002269_muscular_atrophy0.58056745
155MP0005408_hypopigmentation0.57830905
156MP0002909_abnormal_adrenal_gland0.56784169
157MP0003137_abnormal_impulse_conducting0.56630002
158MP0001943_abnormal_respiration0.55356405
159MP0004883_abnormal_blood_vessel0.55105366
160MP0000613_abnormal_salivary_gland0.54978752
161MP0003890_abnormal_embryonic-extraembry0.54958858
162MP0004085_abnormal_heartbeat0.53938009
163MP0000604_amyloidosis0.53699208
164MP0006036_abnormal_mitochondrial_physio0.52664856
165MP0009697_abnormal_copulation0.51948393
166MP0009250_abnormal_appendicular_skeleto0.51690779
167MP0001502_abnormal_circadian_rhythm0.51232310
168MP0002069_abnormal_eating/drinking_beha0.50473046
169MP0005410_abnormal_fertilization0.50421274
170MP0003879_abnormal_hair_cell0.48519313
171MP0003122_maternal_imprinting0.46662663
172MP0008789_abnormal_olfactory_epithelium0.46472366
173MP0003861_abnormal_nervous_system0.45736909
174MP0005379_endocrine/exocrine_gland_phen0.45604364
175MP0002972_abnormal_cardiac_muscle0.45031518

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.66656748
2Ulnar claw (HP:0001178)6.53091493
3Popliteal pterygium (HP:0009756)6.05257396
4Termporal pattern (HP:0011008)5.61264543
5Insidious onset (HP:0003587)5.61264543
6Pheochromocytoma (HP:0002666)5.00018737
7Neuroendocrine neoplasm (HP:0100634)4.68369741
8Myotonia (HP:0002486)4.63902082
9Action tremor (HP:0002345)4.56927626
10Limb dystonia (HP:0002451)4.44460963
11Thoracolumbar scoliosis (HP:0002944)4.15643338
12Supernumerary spleens (HP:0009799)4.13997177
13Abnormality of the vocal cords (HP:0008777)4.04410154
14Distal arthrogryposis (HP:0005684)3.98462139
15Submucous cleft hard palate (HP:0000176)3.90110234
16Postural tremor (HP:0002174)3.84712114
17Right ventricular cardiomyopathy (HP:0011663)3.73136402
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.72689983
19Abnormality of the labia minora (HP:0012880)3.69201993
20Febrile seizures (HP:0002373)3.67392563
21Chin dimple (HP:0010751)3.59192645
22Gonadotropin excess (HP:0000837)3.58103239
23Progressive cerebellar ataxia (HP:0002073)3.56836798
24Abnormality of pain sensation (HP:0010832)3.53377209
25Impaired pain sensation (HP:0007328)3.53377209
26Hypothermia (HP:0002045)3.45705498
27Acanthocytosis (HP:0001927)3.40970825
28Segmental peripheral demyelination/remyelination (HP:0003481)3.37073176
29Down-sloping shoulders (HP:0200021)3.29317841
30Colon cancer (HP:0003003)3.24125440
31Overlapping toe (HP:0001845)3.23878554
32Intrahepatic cholestasis (HP:0001406)3.23422252
33Proximal tubulopathy (HP:0000114)3.22841332
34Aplasia/Hypoplasia of the tibia (HP:0005772)3.17005526
35Chronic hepatic failure (HP:0100626)3.15892513
36Ventricular tachycardia (HP:0004756)3.06791319
37Abnormal hair whorl (HP:0010721)3.02688983
38Foot dorsiflexor weakness (HP:0009027)2.99651075
39Abnormal hemoglobin (HP:0011902)2.99305306
40Mask-like facies (HP:0000298)2.97716277
41Myelomeningocele (HP:0002475)2.94571729
42Hypokinesia (HP:0002375)2.93643911
43Bilateral microphthalmos (HP:0007633)2.93575267
44Hypophosphatemic rickets (HP:0004912)2.91922564
45Failure to thrive in infancy (HP:0001531)2.84448165
46Abnormal lung lobation (HP:0002101)2.84272063
47Retinal atrophy (HP:0001105)2.81101271
48Focal seizures (HP:0007359)2.79899849
49Hammertoe (HP:0001765)2.76934931
50Steppage gait (HP:0003376)2.76871597
51Neoplasm of the peripheral nervous system (HP:0100007)2.76417474
52Embryonal renal neoplasm (HP:0011794)2.74417070
53Aplasia/Hypoplasia of the brainstem (HP:0007362)2.73084781
54Hypoplasia of the brainstem (HP:0002365)2.73084781
55Abdominal situs inversus (HP:0003363)2.71787771
56Abnormality of abdominal situs (HP:0011620)2.71787771
57Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.71306479
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70774382
59Acute necrotizing encephalopathy (HP:0006965)2.70162054
60Impaired proprioception (HP:0010831)2.70106873
61Atonic seizures (HP:0010819)2.68552009
62Abnormality of the foot musculature (HP:0001436)2.67874762
63Bifid tongue (HP:0010297)2.63344497
64Hypomagnesemia (HP:0002917)2.62562955
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.60589632
66Abnormal pancreas size (HP:0012094)2.60234191
67Short tibia (HP:0005736)2.57776459
68Absent radius (HP:0003974)2.57522697
69Absent phalangeal crease (HP:0006109)2.56674824
70Congenital sensorineural hearing impairment (HP:0008527)2.56306436
71Chromsome breakage (HP:0040012)2.56261722
72Septo-optic dysplasia (HP:0100842)2.51845297
73Abnormality of magnesium homeostasis (HP:0004921)2.50338721
74Abnormality of the lower motor neuron (HP:0002366)2.48644365
75Decreased muscle mass (HP:0003199)2.47615134
76Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.46626251
77Preaxial foot polydactyly (HP:0001841)2.44793493
78Facial shape deformation (HP:0011334)2.44301032
79Potter facies (HP:0002009)2.44301032
80Vitreoretinal degeneration (HP:0000655)2.44278302
81Bile duct proliferation (HP:0001408)2.44245152
82Abnormal biliary tract physiology (HP:0012439)2.44245152
83Patent foramen ovale (HP:0001655)2.43557449
84Osteomalacia (HP:0002749)2.41977844
85Absent forearm bone (HP:0003953)2.38147186
86Aplasia involving forearm bones (HP:0009822)2.38147186
87Nephroblastoma (Wilms tumor) (HP:0002667)2.37403684
88Cerebral hypomyelination (HP:0006808)2.35589081
89Hypoventilation (HP:0002791)2.35305898
90Cerebral hemorrhage (HP:0001342)2.34031793
91Pancreatic cysts (HP:0001737)2.33098288
92Carpal bone hypoplasia (HP:0001498)2.31990985
93Syncope (HP:0001279)2.31964578
94Aplasia/Hypoplasia of the fovea (HP:0008060)2.31421562
95Hypoplasia of the fovea (HP:0007750)2.31421562
96Hyperglycinemia (HP:0002154)2.31396452
97Abnormal mitochondria in muscle tissue (HP:0008316)2.28596503
98Bundle branch block (HP:0011710)2.26810826
99Truncal ataxia (HP:0002078)2.25885203
100Partial duplication of thumb phalanx (HP:0009944)2.24791561
101Increased corneal curvature (HP:0100692)2.24637373
102Keratoconus (HP:0000563)2.24637373
103Sensory axonal neuropathy (HP:0003390)2.24590615
104Abnormality of the ischium (HP:0003174)2.22870966
105Progressive macrocephaly (HP:0004481)2.22050606
106Hypoglycemic coma (HP:0001325)2.19611100
107Pterygium (HP:0001059)2.19221131
108Enlarged kidneys (HP:0000105)2.17439509
109Decreased circulating renin level (HP:0003351)2.16081997
110Neoplasm of the small intestine (HP:0100833)2.15278241
111Nausea (HP:0002018)2.14469027
112Hypercortisolism (HP:0001578)2.13077875
113Papillary thyroid carcinoma (HP:0002895)2.11132819
114Abnormality of the aortic arch (HP:0012303)2.10559375
115Meckel diverticulum (HP:0002245)2.09952200
116Coarctation of aorta (HP:0001680)2.06914459
117Muscle stiffness (HP:0003552)2.06715632
118Decreased motor nerve conduction velocity (HP:0003431)2.04920147
119Lower limb hyperreflexia (HP:0002395)2.04256490
120Thyroid carcinoma (HP:0002890)2.03677838
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02765539
122Abnormality of the fovea (HP:0000493)2.02686002
123Duodenal stenosis (HP:0100867)2.02342301
124Small intestinal stenosis (HP:0012848)2.02342301
125Distal sensory impairment (HP:0002936)2.01957848
126Diminished movement (HP:0002374)2.01616749
127Abnormal finger flexion creases (HP:0006143)2.01309580
128Neuroblastoma (HP:0003006)2.01223404
129Primitive neuroectodermal tumor (HP:0030065)2.01223404
130Neuroblastic tumors (HP:0004376)2.01223404
131Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.01223404
132Enlarged penis (HP:0000040)2.01200841
133Clitoromegaly (HP:0000057)2.00984625
134Abnormality of the ileum (HP:0001549)2.00516986
135Absent eyebrow (HP:0002223)1.99363493
136Acute encephalopathy (HP:0006846)1.98803699
137Abnormality of the epiphysis of the femoral head (HP:0010574)1.96651653
138Cutaneous finger syndactyly (HP:0010554)1.95647841
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95193359
140Oligodactyly (hands) (HP:0001180)1.94932623
141Subcapsular cataract (HP:0000523)1.93629741
142Neonatal onset (HP:0003623)1.92529956
143Split hand (HP:0001171)1.91937075
144Abnormality of chromosome stability (HP:0003220)1.91318381
145Ankle clonus (HP:0011448)1.90925360
146Posterior subcapsular cataract (HP:0007787)1.89862429
147Genital tract atresia (HP:0001827)1.89720153
148Dysautonomia (HP:0002459)1.88904430
149Abnormality of the duodenum (HP:0002246)1.88392716
150Hyperglycinuria (HP:0003108)1.88029584
151Choanal stenosis (HP:0000452)1.87710818
152Duplication of thumb phalanx (HP:0009942)1.87513506
153Abnormality of the parathyroid morphology (HP:0011766)1.86029943
154Irregular epiphyses (HP:0010582)1.85772663
155Partial duplication of the phalanx of hand (HP:0009999)1.84838069
156Neoplasm of the colon (HP:0100273)1.84139563
157Triphalangeal thumb (HP:0001199)1.84080460
158Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.82814989
159Abnormality of femoral epiphyses (HP:0006499)1.82814989
160Bicornuate uterus (HP:0000813)1.82711218
161Supranuclear gaze palsy (HP:0000605)1.82004143
162Horizontal nystagmus (HP:0000666)1.81903516
163Abnormality of the renal cortex (HP:0011035)1.81215054
164Mitochondrial inheritance (HP:0001427)1.80746434
165Abnormality of calcium-phosphate metabolism (HP:0100530)1.80476531
166Abnormality of the nasolacrimal system (HP:0000614)1.79061824
167Absent septum pellucidum (HP:0001331)1.78784684
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.78479760
169Vertebral arch anomaly (HP:0008438)1.78448642
170Focal motor seizures (HP:0011153)1.77548098
171Vaginal atresia (HP:0000148)1.76550428
172Patellar aplasia (HP:0006443)1.76271526
173Amelogenesis imperfecta (HP:0000705)1.76251762
174Infertility (HP:0000789)1.76020997
175Craniofacial dystonia (HP:0012179)1.75425574
176Chorioretinal atrophy (HP:0000533)1.75399805
177Hepatoblastoma (HP:0002884)1.75380344
178Aplasia/Hypoplasia of the sternum (HP:0006714)1.75264132
179Abnormality of the pubic bones (HP:0003172)1.74444924
180Anosmia (HP:0000458)1.74275691
181Limited hip movement (HP:0008800)1.74090374
182Urinary urgency (HP:0000012)1.73662340
183Generalized tonic-clonic seizures (HP:0002069)1.73369126
184Biliary tract neoplasm (HP:0100574)1.71866404
185Anencephaly (HP:0002323)1.71613736
186Sudden death (HP:0001699)1.71511098
187Multiple enchondromatosis (HP:0005701)1.70950925
188Cupped ear (HP:0000378)1.70573719
189Abnormality of the septum pellucidum (HP:0007375)1.70406571
190Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69905279
191Pancreatic fibrosis (HP:0100732)1.69208353
192Abnormality of serine family amino acid metabolism (HP:0010894)1.67067438
193Abnormality of glycine metabolism (HP:0010895)1.67067438
194Heart block (HP:0012722)1.66918355
195Skin pits (HP:0100276)1.66366254
196Median cleft lip (HP:0000161)1.65569896
197Optic nerve hypoplasia (HP:0000609)1.64605038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.80851280
2GRK54.49633381
3LATS14.41946263
4OBSCN3.79374112
5STK38L3.63446639
6ARAF3.62205038
7FLT33.56656698
8FRK3.34075355
9LIMK13.19569402
10ZAK3.15560551
11NTRK33.10361972
12MAPKAPK53.00968880
13KSR23.00638297
14MAPKAPK32.86383745
15MAP3K92.70649684
16ACVR1B2.57762465
17TTK2.50732922
18WNK32.50717376
19SIK32.47101134
20DAPK22.46967775
21LATS22.36456046
22MINK12.35861959
23TNIK2.32171546
24TRIM282.28864765
25MARK12.08979311
26CASK2.00961251
27PIM21.98802298
28MAPK131.95117206
29LMTK21.95063693
30MAP3K121.87783588
31RET1.86761630
32EIF2AK31.86009154
33CDK191.77174815
34MAP3K21.75953185
35PIK3CA1.74078376
36PBK1.69040718
37BRAF1.62432649
38PLK41.61957334
39TSSK61.51626757
40NEK11.51435143
41BUB11.49645682
42STK31.45189948
43NTRK11.42156417
44PAK61.39548061
45CSNK1G31.39021672
46NLK1.39003929
47MKNK21.37331486
48UHMK11.35926038
49BMPR1B1.32560506
50TESK11.31926910
51PINK11.27208420
52BCR1.26209909
53OXSR11.24353701
54CDK141.23621524
55BRSK21.22998732
56TESK21.20596124
57CSNK1A1L1.18677161
58PHKG21.12384061
59PHKG11.12384061
60TAOK11.10875736
61CSNK1G21.10732205
62DYRK21.10699495
63PLK11.08475252
64RPS6KA21.07952548
65CDK181.07647873
66CAMKK21.02806517
67MELK1.01892620
68PLK31.01773997
69EPHA30.99671856
70PTK2B0.99402621
71MAP3K40.99179734
72DAPK10.98521046
73MKNK10.97290355
74CDK150.94967405
75GRK70.94771418
76STK240.94719106
77MAP2K10.93891401
78FGFR10.92670412
79WNK40.92564232
80DMPK0.89748051
81TIE10.89711663
82CDK80.85252879
83CDK11A0.84172034
84MAP2K40.83928830
85CDK50.83801604
86RAF10.83583474
87VRK10.83217163
88CSNK1G10.83143756
89ADRBK10.82861921
90PLK20.82815283
91WEE10.82443263
92TGFBR10.81953985
93STK380.81151927
94NEK60.76612495
95STK390.76479903
96NEK20.73657939
97FER0.71481687
98RPS6KB20.70147560
99AURKA0.69372686
100CAMK2D0.67474552
101CAMK2B0.67421688
102NME10.66628082
103PDK20.63800246
104SGK4940.62360159
105SGK2230.62360159
106PIK3CG0.61062607
107MET0.60262726
108BRSK10.59751807
109CHEK20.59556343
110PDGFRA0.58874730
111MAP3K130.58528024
112CAMK2G0.56634143
113PAK30.55752291
114NUAK10.55498253
115MOS0.55197297
116NEK90.55146576
117EPHB20.54124935
118SIK20.53532800
119CDK120.52334577
120SGK20.51775634
121MAP3K10.48565517
122NME20.47827846
123CDC70.46441386
124CSNK1E0.45874541
125TLK10.45196304
126NTRK20.44880877
127KSR10.44812289
128BRD40.43609803
129CDK70.43584298
130ATM0.43246860
131STK160.40971236
132EIF2AK20.40228124
133AKT30.40209270
134MAP2K70.39521949
135GRK10.39477054
136MAP3K100.38607653
137SRPK10.38415794
138PRKCI0.38029520
139PRKACA0.38002927
140PAK10.37416335
141EPHA40.35535020
142BCKDK0.35109969
143CAMK2A0.34656956
144PRKG10.34489892
145PRKACG0.34378578
146PRKCG0.34209915
147CDK90.34146132
148HIPK20.33869840
149AURKB0.33859955
150FGFR20.32702223
151ABL20.30955802
152PASK0.30315203
153PRKD30.29141873
154PIM10.28472212
155MST40.28306408
156CHEK10.27860400
157ATR0.27268122
158TXK0.27107238
159PRKCZ0.26847054
160PRKACB0.26466004
161MAP2K20.25059408
162CDK10.24969179
163MAPKAPK20.24898706
164DAPK30.24634536
165MAP3K80.24402171
166CDK20.24274092
167RPS6KB10.23739284
168ERBB40.23697637
169CAMK40.23302805

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.96061507
2Oxidative phosphorylation_Homo sapiens_hsa001903.92096975
3Parkinsons disease_Homo sapiens_hsa050123.77771815
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.18865577
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.15103901
6Proteasome_Homo sapiens_hsa030503.11963159
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.96205814
8Ribosome_Homo sapiens_hsa030102.78595775
9Cardiac muscle contraction_Homo sapiens_hsa042602.78165909
10Cysteine and methionine metabolism_Homo sapiens_hsa002702.78149542
11Vitamin digestion and absorption_Homo sapiens_hsa049772.53071433
12Taste transduction_Homo sapiens_hsa047422.52891036
13Huntingtons disease_Homo sapiens_hsa050162.51364112
14Alzheimers disease_Homo sapiens_hsa050102.49309256
15Collecting duct acid secretion_Homo sapiens_hsa049662.48231858
16Basal transcription factors_Homo sapiens_hsa030222.46732918
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.42359553
18Cell cycle_Homo sapiens_hsa041102.40025836
19Propanoate metabolism_Homo sapiens_hsa006402.24456706
20Mismatch repair_Homo sapiens_hsa034302.18842914
21Selenocompound metabolism_Homo sapiens_hsa004502.05474341
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95156595
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91976587
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87724173
25Regulation of autophagy_Homo sapiens_hsa041401.82810742
26Thyroid cancer_Homo sapiens_hsa052161.78921960
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78616349
28TGF-beta signaling pathway_Homo sapiens_hsa043501.77229637
29RNA transport_Homo sapiens_hsa030131.76214869
30Steroid biosynthesis_Homo sapiens_hsa001001.75151411
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74962917
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.64207469
33Fanconi anemia pathway_Homo sapiens_hsa034601.63718521
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62328920
35RNA degradation_Homo sapiens_hsa030181.60810392
36Adherens junction_Homo sapiens_hsa045201.54562171
37RNA polymerase_Homo sapiens_hsa030201.51712653
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47567029
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.46852950
40Fat digestion and absorption_Homo sapiens_hsa049751.44921975
41Homologous recombination_Homo sapiens_hsa034401.41038027
42Vibrio cholerae infection_Homo sapiens_hsa051101.39017411
43Olfactory transduction_Homo sapiens_hsa047401.36781252
44Non-homologous end-joining_Homo sapiens_hsa034501.34645710
45Insulin secretion_Homo sapiens_hsa049111.33565014
46Hippo signaling pathway_Homo sapiens_hsa043901.29906696
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25545992
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18722756
49Dopaminergic synapse_Homo sapiens_hsa047281.18084152
50Cholinergic synapse_Homo sapiens_hsa047251.16601675
51Sphingolipid metabolism_Homo sapiens_hsa006001.13695590
52Ovarian steroidogenesis_Homo sapiens_hsa049131.07363501
53Base excision repair_Homo sapiens_hsa034101.06481731
54DNA replication_Homo sapiens_hsa030301.06451303
55Glycerolipid metabolism_Homo sapiens_hsa005611.04047837
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03417495
57Oocyte meiosis_Homo sapiens_hsa041141.03388718
58Butanoate metabolism_Homo sapiens_hsa006501.03119733
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03058345
60Mineral absorption_Homo sapiens_hsa049781.02877161
61Phototransduction_Homo sapiens_hsa047441.02567451
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01882786
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.99702765
64p53 signaling pathway_Homo sapiens_hsa041150.99438649
65Phagosome_Homo sapiens_hsa041450.99304487
66Tight junction_Homo sapiens_hsa045300.98324649
67Glutamatergic synapse_Homo sapiens_hsa047240.97966217
68Nicotine addiction_Homo sapiens_hsa050330.97759084
69Lysine degradation_Homo sapiens_hsa003100.93132988
70Melanoma_Homo sapiens_hsa052180.92706103
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92469358
72Histidine metabolism_Homo sapiens_hsa003400.90964431
73Serotonergic synapse_Homo sapiens_hsa047260.90840162
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88464751
75Ether lipid metabolism_Homo sapiens_hsa005650.88023647
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86776787
77Pyruvate metabolism_Homo sapiens_hsa006200.85664008
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84907299
79Arginine and proline metabolism_Homo sapiens_hsa003300.84552037
80Dilated cardiomyopathy_Homo sapiens_hsa054140.84462643
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84422105
82Salivary secretion_Homo sapiens_hsa049700.84218943
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84188826
84Nucleotide excision repair_Homo sapiens_hsa034200.83985340
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83845156
86Rheumatoid arthritis_Homo sapiens_hsa053230.82999788
87Tyrosine metabolism_Homo sapiens_hsa003500.81633182
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81500496
89Cocaine addiction_Homo sapiens_hsa050300.77857028
90Circadian entrainment_Homo sapiens_hsa047130.77772303
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77531040
92Long-term potentiation_Homo sapiens_hsa047200.77433187
93GABAergic synapse_Homo sapiens_hsa047270.76618260
94Amphetamine addiction_Homo sapiens_hsa050310.73417653
95N-Glycan biosynthesis_Homo sapiens_hsa005100.73087947
96Glutathione metabolism_Homo sapiens_hsa004800.70638270
97One carbon pool by folate_Homo sapiens_hsa006700.69419156
98Dorso-ventral axis formation_Homo sapiens_hsa043200.69335042
99Bile secretion_Homo sapiens_hsa049760.69322195
100Fructose and mannose metabolism_Homo sapiens_hsa000510.68806570
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68604456
102Fatty acid degradation_Homo sapiens_hsa000710.68111579
103Gap junction_Homo sapiens_hsa045400.67081642
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66947980
105Endocytosis_Homo sapiens_hsa041440.66536143
106Insulin signaling pathway_Homo sapiens_hsa049100.65891926
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.64279489
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63122552
109Tryptophan metabolism_Homo sapiens_hsa003800.62914139
110Biosynthesis of amino acids_Homo sapiens_hsa012300.62694429
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.62492420
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.61999433
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.61231927
114Bladder cancer_Homo sapiens_hsa052190.61090653
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59964027
116mRNA surveillance pathway_Homo sapiens_hsa030150.59174010
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58332631
118Linoleic acid metabolism_Homo sapiens_hsa005910.58079020
119Fatty acid metabolism_Homo sapiens_hsa012120.58052078
120Folate biosynthesis_Homo sapiens_hsa007900.57474917
121Galactose metabolism_Homo sapiens_hsa000520.56579008
122Fatty acid elongation_Homo sapiens_hsa000620.55019481
123Thyroid hormone synthesis_Homo sapiens_hsa049180.54017803
124cAMP signaling pathway_Homo sapiens_hsa040240.53489788
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.52355854
126Morphine addiction_Homo sapiens_hsa050320.51899580
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50995412
128Purine metabolism_Homo sapiens_hsa002300.50664104
129Glioma_Homo sapiens_hsa052140.50590085
130Peroxisome_Homo sapiens_hsa041460.50058256
131Melanogenesis_Homo sapiens_hsa049160.49941033
132Prolactin signaling pathway_Homo sapiens_hsa049170.49232645
133Axon guidance_Homo sapiens_hsa043600.48203285
134Caffeine metabolism_Homo sapiens_hsa002320.47346976
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45225078
136Endometrial cancer_Homo sapiens_hsa052130.44779706
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44568276
138HIF-1 signaling pathway_Homo sapiens_hsa040660.44488884
139Alcoholism_Homo sapiens_hsa050340.44135141
140Oxytocin signaling pathway_Homo sapiens_hsa049210.43183045
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42810406
142Basal cell carcinoma_Homo sapiens_hsa052170.42130855
143Wnt signaling pathway_Homo sapiens_hsa043100.42007136
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41812662
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41535638
146Pyrimidine metabolism_Homo sapiens_hsa002400.40203558
147Long-term depression_Homo sapiens_hsa047300.40034666
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.38603520
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38449355
150Epstein-Barr virus infection_Homo sapiens_hsa051690.37491070
151ErbB signaling pathway_Homo sapiens_hsa040120.36985786
152VEGF signaling pathway_Homo sapiens_hsa043700.36769170
153Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36521301
154Protein digestion and absorption_Homo sapiens_hsa049740.35841211
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35530045
156GnRH signaling pathway_Homo sapiens_hsa049120.35431687
157Hedgehog signaling pathway_Homo sapiens_hsa043400.35284636
158Prion diseases_Homo sapiens_hsa050200.35273728
159Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35141357
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33957512
161Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33614037
162Calcium signaling pathway_Homo sapiens_hsa040200.27411446
163Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27104902
164Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26216806
165Metabolic pathways_Homo sapiens_hsa011000.26050159
166Pancreatic secretion_Homo sapiens_hsa049720.25914168
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24569391

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