FAM19A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80523756
2locomotory exploration behavior (GO:0035641)5.56929264
3synaptic vesicle maturation (GO:0016188)5.53253700
4vocalization behavior (GO:0071625)5.25210904
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21872215
6synaptic vesicle exocytosis (GO:0016079)5.18681901
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14774693
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11807560
9glutamate secretion (GO:0014047)4.81418336
10regulation of glutamate receptor signaling pathway (GO:1900449)4.79713502
11regulation of synaptic vesicle exocytosis (GO:2000300)4.78092168
12neuron cell-cell adhesion (GO:0007158)4.69671014
13neuronal action potential propagation (GO:0019227)4.65066567
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.58198091
15central nervous system myelination (GO:0022010)4.55901719
16axon ensheathment in central nervous system (GO:0032291)4.55901719
17protein localization to synapse (GO:0035418)4.50090445
18neurotransmitter secretion (GO:0007269)4.37644986
19exploration behavior (GO:0035640)4.37216661
20cerebellar granule cell differentiation (GO:0021707)4.36519497
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.33040289
22regulation of neuronal synaptic plasticity (GO:0048168)4.31681136
23regulation of synaptic vesicle transport (GO:1902803)4.26371847
24layer formation in cerebral cortex (GO:0021819)4.24312072
25positive regulation of dendritic spine morphogenesis (GO:0061003)4.20795473
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.11500312
27amino acid import (GO:0043090)4.09630206
28glutamate receptor signaling pathway (GO:0007215)4.08613505
29dendritic spine morphogenesis (GO:0060997)4.04335240
30synaptic transmission, glutamatergic (GO:0035249)4.02748033
31regulation of synapse structural plasticity (GO:0051823)3.99771541
32cell migration in hindbrain (GO:0021535)3.99341804
33gamma-aminobutyric acid transport (GO:0015812)3.99064684
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.97407176
35neuron recognition (GO:0008038)3.90103861
36neuron-neuron synaptic transmission (GO:0007270)3.83133124
37long-term memory (GO:0007616)3.72936853
38proline transport (GO:0015824)3.72080390
39transmission of nerve impulse (GO:0019226)3.71080035
40neurotransmitter-gated ion channel clustering (GO:0072578)3.70900306
41potassium ion homeostasis (GO:0055075)3.69412305
42cellular potassium ion homeostasis (GO:0030007)3.66554327
43neurotransmitter transport (GO:0006836)3.62944999
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62720496
45positive regulation of membrane potential (GO:0045838)3.60427162
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59875429
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59298794
48axonal fasciculation (GO:0007413)3.56775187
49potassium ion import (GO:0010107)3.54981472
50establishment of mitochondrion localization (GO:0051654)3.53654092
51regulation of synapse maturation (GO:0090128)3.50183696
52regulation of dendritic spine morphogenesis (GO:0061001)3.48863353
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.44646310
54regulation of synaptic plasticity (GO:0048167)3.44270093
55regulation of postsynaptic membrane potential (GO:0060078)3.43843278
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39586354
57neuromuscular process controlling posture (GO:0050884)3.38321202
58regulation of neurotransmitter levels (GO:0001505)3.35754048
59activation of protein kinase A activity (GO:0034199)3.35439608
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34902015
61long-term synaptic potentiation (GO:0060291)3.33229465
62neuronal ion channel clustering (GO:0045161)3.32613381
63positive regulation of synapse maturation (GO:0090129)3.31073844
64cellular sodium ion homeostasis (GO:0006883)3.29901734
65neuromuscular process controlling balance (GO:0050885)3.29858237
66pyrimidine nucleobase catabolic process (GO:0006208)3.29246652
67postsynaptic membrane organization (GO:0001941)3.28250316
68regulation of vesicle fusion (GO:0031338)3.27021941
69sodium ion export (GO:0071436)3.25532093
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24956392
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.23653780
72synaptic vesicle endocytosis (GO:0048488)3.21849512
73regulation of neurotransmitter secretion (GO:0046928)3.20019560
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.19267031
75positive regulation of neurotransmitter transport (GO:0051590)3.17787400
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16478170
77mechanosensory behavior (GO:0007638)3.15353816
78positive regulation of synapse assembly (GO:0051965)3.14846267
79dendrite morphogenesis (GO:0048813)3.13853089
80presynaptic membrane assembly (GO:0097105)3.13759829
81auditory behavior (GO:0031223)3.12176461
82regulation of voltage-gated calcium channel activity (GO:1901385)3.10616179
83C4-dicarboxylate transport (GO:0015740)3.10159674
84regulation of glutamate secretion (GO:0014048)3.09124630
85acidic amino acid transport (GO:0015800)3.08983783
86glycine transport (GO:0015816)3.07341855
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07325225
88response to auditory stimulus (GO:0010996)3.05794045
89membrane hyperpolarization (GO:0060081)3.04237621
90presynaptic membrane organization (GO:0097090)3.03099405
91cerebellar Purkinje cell differentiation (GO:0021702)3.02889368
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02833506
93L-amino acid import (GO:0043092)3.02494396
94neuromuscular synaptic transmission (GO:0007274)3.02401003
95vesicle transport along microtubule (GO:0047496)3.01333419
96cell communication by electrical coupling (GO:0010644)3.00850347
97regulation of neurotransmitter transport (GO:0051588)3.00282251
98positive regulation of dendritic spine development (GO:0060999)3.00209063
99dendritic spine organization (GO:0097061)3.00017530
100learning (GO:0007612)2.99959378
101neurotransmitter uptake (GO:0001504)2.99494945
102prepulse inhibition (GO:0060134)2.98899070
103regulation of dendritic spine development (GO:0060998)2.96730359
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95261130
105positive regulation of neurotransmitter secretion (GO:0001956)2.95204234
106membrane depolarization (GO:0051899)2.94808454
107innervation (GO:0060384)2.94003991
108cerebellar Purkinje cell layer development (GO:0021680)2.93858052
109behavioral fear response (GO:0001662)2.93078671
110behavioral defense response (GO:0002209)2.93078671
111mating behavior (GO:0007617)2.91174065
112response to histamine (GO:0034776)2.90805770
113synapse assembly (GO:0007416)2.90653983
114adult walking behavior (GO:0007628)2.90331533
115regulation of synaptic transmission (GO:0050804)2.90161709
116positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89666161
117regulation of female receptivity (GO:0045924)2.88904849
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88671672
119social behavior (GO:0035176)2.87055233
120intraspecies interaction between organisms (GO:0051703)2.87055233
121synaptic transmission (GO:0007268)2.86908874
122mitochondrion transport along microtubule (GO:0047497)2.85559113
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85559113
124positive regulation of synaptic transmission (GO:0050806)2.85478907
125neuromuscular process (GO:0050905)2.85434596
126membrane depolarization during action potential (GO:0086010)2.83678219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human5.57671977
2GBX2_23144817_ChIP-Seq_PC3_Human3.33299357
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20816144
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18729414
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17448318
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83774844
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83774844
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77107404
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.71493674
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69681481
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.65787978
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61962870
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61694175
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60705385
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58712232
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.57560254
17DROSHA_22980978_ChIP-Seq_HELA_Human2.42640296
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.41049561
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.37084990
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36926973
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24493857
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.22390581
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17592340
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11985030
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05295504
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.02457780
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95774380
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90396179
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79944765
30* AR_21572438_ChIP-Seq_LNCaP_Human1.76690040
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76160367
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75292850
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.69180701
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65060863
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64685356
36SMAD4_21799915_ChIP-Seq_A2780_Human1.53630262
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53414156
38TAF15_26573619_Chip-Seq_HEK293_Human1.50847340
39ZNF274_21170338_ChIP-Seq_K562_Hela1.47377851
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46439718
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43413251
42* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40740761
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.38439293
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37613918
45* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37123199
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.32808399
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31174488
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29981328
49P300_19829295_ChIP-Seq_ESCs_Human1.29266958
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28344234
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28218605
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.26758237
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26244946
54* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26042924
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24663426
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24351906
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21529178
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20737128
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19653078
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18423998
61* AR_19668381_ChIP-Seq_PC3_Human1.17819670
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17637359
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17334408
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15661742
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14829327
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.14024566
67STAT3_23295773_ChIP-Seq_U87_Human1.13928167
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13891075
69AR_25329375_ChIP-Seq_VCAP_Human1.13368059
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10950647
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09859670
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09702518
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09306468
74RNF2_27304074_Chip-Seq_NSC_Mouse1.05563508
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.03181563
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02925671
77KDM2B_26808549_Chip-Seq_K562_Human1.01912741
78* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01603814
79* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00802735
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00272808
81* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99881867
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99715735
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99715735
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99647155
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.99125060
86* TCF4_23295773_ChIP-Seq_U87_Human0.97688453
87* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97080566
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96654233
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96303310
90IGF1R_20145208_ChIP-Seq_DFB_Human0.95882958
91* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95462102
92SOX9_26525672_Chip-Seq_HEART_Mouse0.94930708
93AHR_22903824_ChIP-Seq_MCF-7_Human0.94245056
94* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93757199
95FUS_26573619_Chip-Seq_HEK293_Human0.93466265
96* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92682022
97* RUNX2_22187159_ChIP-Seq_PCA_Human0.92264371
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91389472
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.90917255
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88654662
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88595900
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88360837
103* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88183371
104* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88095671
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.88043533
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87406446
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87278534
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.86714280
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.86241816
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84677114
111TP53_16413492_ChIP-PET_HCT116_Human0.84423220
112* ISL1_27105846_Chip-Seq_CPCs_Mouse0.84393658
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83313586
114CTCF_27219007_Chip-Seq_Bcells_Human0.83243394
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83126181
116TET1_21490601_ChIP-Seq_MESCs_Mouse0.82997311
117* JUN_21703547_ChIP-Seq_K562_Human0.82932825
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82741763
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81061370
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.79634981
121DPY_21335234_ChIP-Seq_ESCs_Mouse0.78264893
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77435261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.16786269
2MP0003880_abnormal_central_pattern4.80278839
3MP0003635_abnormal_synaptic_transmissio4.04184495
4MP0004270_analgesia3.51709571
5MP0009745_abnormal_behavioral_response3.37926854
6MP0002063_abnormal_learning/memory/cond3.22075507
7MP0002064_seizures3.16865194
8MP0009046_muscle_twitch3.00330158
9MP0001968_abnormal_touch/_nociception2.76821628
10MP0002572_abnormal_emotion/affect_behav2.75123365
11MP0005423_abnormal_somatic_nervous2.74814383
12MP0002272_abnormal_nervous_system2.64339246
13MP0002822_catalepsy2.62481702
14MP0001486_abnormal_startle_reflex2.53554317
15MP0002734_abnormal_mechanical_nocicepti2.53073687
16MP0001501_abnormal_sleep_pattern2.20884924
17MP0001440_abnormal_grooming_behavior2.14347040
18MP0002736_abnormal_nociception_after2.02894663
19MP0002733_abnormal_thermal_nociception2.01936537
20MP0002735_abnormal_chemical_nociception2.01889079
21MP0003329_amyloid_beta_deposits1.95783649
22MP0001970_abnormal_pain_threshold1.92011985
23MP0000778_abnormal_nervous_system1.91008244
24MP0002067_abnormal_sensory_capabilities1.90329845
25MP0009780_abnormal_chondrocyte_physiolo1.86041212
26MP0006276_abnormal_autonomic_nervous1.85055479
27MP0004858_abnormal_nervous_system1.82858731
28MP0008569_lethality_at_weaning1.81011873
29MP0002184_abnormal_innervation1.80774235
30MP0002557_abnormal_social/conspecific_i1.75917375
31MP0002909_abnormal_adrenal_gland1.74000316
32MP0004885_abnormal_endolymph1.68643051
33MP0003122_maternal_imprinting1.67312916
34MP0004924_abnormal_behavior1.66017236
35MP0005386_behavior/neurological_phenoty1.66017236
36MP0004811_abnormal_neuron_physiology1.65853596
37MP0005646_abnormal_pituitary_gland1.65163876
38MP0000955_abnormal_spinal_cord1.63506501
39MP0005645_abnormal_hypothalamus_physiol1.63457944
40MP0004142_abnormal_muscle_tone1.51097037
41MP0001984_abnormal_olfaction1.47823302
42MP0002882_abnormal_neuron_morphology1.45565281
43MP0002066_abnormal_motor_capabilities/c1.45455190
44MP0001529_abnormal_vocalization1.39931402
45MP0001905_abnormal_dopamine_level1.38495271
46MP0003787_abnormal_imprinting1.34484585
47MP0001502_abnormal_circadian_rhythm1.31812230
48MP0002653_abnormal_ependyma_morphology1.28466756
49MP0003879_abnormal_hair_cell1.28184611
50MP0003633_abnormal_nervous_system1.27649958
51MP0003283_abnormal_digestive_organ1.16256481
52MP0006292_abnormal_olfactory_placode1.15628943
53MP0000920_abnormal_myelination1.15318246
54MP0002152_abnormal_brain_morphology1.14707931
55MP0000751_myopathy1.14324277
56MP0003631_nervous_system_phenotype1.13077178
57MP0000566_synostosis1.11985281
58MP0003690_abnormal_glial_cell1.11259519
59MP0003634_abnormal_glial_cell1.10193687
60MP0004145_abnormal_muscle_electrophysio1.07710178
61MP0000013_abnormal_adipose_tissue1.02015712
62MP0002229_neurodegeneration1.01247713
63MP0004742_abnormal_vestibular_system0.99011288
64MP0001188_hyperpigmentation0.97930978
65MP0003136_yellow_coat_color0.95309925
66MP0002069_abnormal_eating/drinking_beha0.94021161
67MP0001177_atelectasis0.93517855
68MP0002837_dystrophic_cardiac_calcinosis0.92684853
69MP0003632_abnormal_nervous_system0.92158696
70MP0010386_abnormal_urinary_bladder0.90133638
71MP0000631_abnormal_neuroendocrine_gland0.89088952
72MP0005551_abnormal_eye_electrophysiolog0.88878131
73MP0004133_heterotaxia0.87874473
74MP0001963_abnormal_hearing_physiology0.87157724
75MP0008877_abnormal_DNA_methylation0.85170310
76MP0001485_abnormal_pinna_reflex0.82896970
77MP0005499_abnormal_olfactory_system0.82387568
78MP0005394_taste/olfaction_phenotype0.82387568
79MP0002752_abnormal_somatic_nervous0.81825208
80MP0005623_abnormal_meninges_morphology0.80560313
81MP0001299_abnormal_eye_distance/0.80247331
82MP0004085_abnormal_heartbeat0.78832879
83MP0003938_abnormal_ear_development0.78737388
84MP0000604_amyloidosis0.78636445
85MP0008872_abnormal_physiological_respon0.77339562
86MP0005535_abnormal_body_temperature0.75881754
87MP0008874_decreased_physiological_sensi0.75788074
88MP0003119_abnormal_digestive_system0.74945878
89MP0001346_abnormal_lacrimal_gland0.74567676
90MP0003075_altered_response_to0.74052549
91MP0002249_abnormal_larynx_morphology0.73615051
92MP0005409_darkened_coat_color0.72611140
93MP0003123_paternal_imprinting0.71903740
94MP0003890_abnormal_embryonic-extraembry0.69340424
95MP0002638_abnormal_pupillary_reflex0.68460285
96MP0008961_abnormal_basal_metabolism0.67544560
97MP0002090_abnormal_vision0.66920556
98MP0000049_abnormal_middle_ear0.66884746
99MP0008789_abnormal_olfactory_epithelium0.66541937
100MP0003137_abnormal_impulse_conducting0.66077847
101MP0000747_muscle_weakness0.64654399
102MP0006072_abnormal_retinal_apoptosis0.63072321
103MP0003861_abnormal_nervous_system0.62980932
104MP0004043_abnormal_pH_regulation0.62809637
105MP0010770_preweaning_lethality0.62676505
106MP0002082_postnatal_lethality0.62676505
107MP0001943_abnormal_respiration0.62206682
108MP0004233_abnormal_muscle_weight0.61611744
109MP0002081_perinatal_lethality0.60659892
110MP0002102_abnormal_ear_morphology0.60285978
111MP0010768_mortality/aging0.59626529
112MP0005171_absent_coat_pigmentation0.59574449
113MP0005187_abnormal_penis_morphology0.58997714
114MP0001986_abnormal_taste_sensitivity0.58308479
115MP0001664_abnormal_digestion0.58046772
116MP0003121_genomic_imprinting0.57302653
117MP0002089_abnormal_postnatal_growth/wei0.57156869
118MP0000534_abnormal_ureter_morphology0.56989813
119MP0005167_abnormal_blood-brain_barrier0.56726701
120MP0002751_abnormal_autonomic_nervous0.56664401
121MP0004484_altered_response_of0.56289112
122MP0000026_abnormal_inner_ear0.56146758
123MP0010769_abnormal_survival0.52764788

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.20822485
2Myokymia (HP:0002411)6.58204981
3Focal seizures (HP:0007359)5.42960908
4Visual hallucinations (HP:0002367)5.03164499
5Atonic seizures (HP:0010819)4.62862067
6Epileptic encephalopathy (HP:0200134)4.36673580
7Absence seizures (HP:0002121)4.03693584
8Progressive cerebellar ataxia (HP:0002073)4.02972202
9Action tremor (HP:0002345)3.86192745
10Febrile seizures (HP:0002373)3.85266249
11Supranuclear gaze palsy (HP:0000605)3.82046687
12Generalized tonic-clonic seizures (HP:0002069)3.69988125
13Dialeptic seizures (HP:0011146)3.67994491
14Ankle clonus (HP:0011448)3.43458023
15Broad-based gait (HP:0002136)3.18143758
16Depression (HP:0000716)3.12281513
17Neurofibrillary tangles (HP:0002185)3.07884516
18Dysmetria (HP:0001310)3.07004042
19Dysdiadochokinesis (HP:0002075)3.05386067
20Impaired vibration sensation in the lower limbs (HP:0002166)3.03856080
21Anxiety (HP:0000739)2.98589445
22Abnormal eating behavior (HP:0100738)2.97512335
23Poor eye contact (HP:0000817)2.95953294
24Hyperventilation (HP:0002883)2.92828088
25Cerebral inclusion bodies (HP:0100314)2.92148445
26Truncal ataxia (HP:0002078)2.81812925
27Gaze-evoked nystagmus (HP:0000640)2.80126212
28Urinary bladder sphincter dysfunction (HP:0002839)2.77976734
29Megalencephaly (HP:0001355)2.77923061
30Insidious onset (HP:0003587)2.76377769
31Termporal pattern (HP:0011008)2.76377769
32Amblyopia (HP:0000646)2.74645598
33Impaired social interactions (HP:0000735)2.72280157
34Abnormal social behavior (HP:0012433)2.72280157
35Cerebral hypomyelination (HP:0006808)2.70291851
36Obstructive sleep apnea (HP:0002870)2.69823760
37Postural instability (HP:0002172)2.67358286
38Mutism (HP:0002300)2.61063000
39Urinary urgency (HP:0000012)2.60611682
40Spastic gait (HP:0002064)2.60455925
41Hemiparesis (HP:0001269)2.59024583
42Intention tremor (HP:0002080)2.53675340
43Papilledema (HP:0001085)2.53175292
44Scanning speech (HP:0002168)2.52774565
45Excessive salivation (HP:0003781)2.48596456
46Drooling (HP:0002307)2.48596456
47Abnormality of the corticospinal tract (HP:0002492)2.46781840
48Abnormality of the lower motor neuron (HP:0002366)2.43672985
49Progressive inability to walk (HP:0002505)2.42779699
50Pheochromocytoma (HP:0002666)2.41676747
51Genetic anticipation (HP:0003743)2.39978799
52Epileptiform EEG discharges (HP:0011182)2.36904490
53Torticollis (HP:0000473)2.34120645
54Akinesia (HP:0002304)2.33806476
55Limb dystonia (HP:0002451)2.31150811
56EEG with generalized epileptiform discharges (HP:0011198)2.30166198
57Fetal akinesia sequence (HP:0001989)2.29656999
58Focal dystonia (HP:0004373)2.26182013
59Polyphagia (HP:0002591)2.25721220
60Abnormality of binocular vision (HP:0011514)2.24714903
61Diplopia (HP:0000651)2.24714903
62Lower limb muscle weakness (HP:0007340)2.23783773
63Split foot (HP:0001839)2.23353676
64Bradykinesia (HP:0002067)2.23017518
65Hemiplegia (HP:0002301)2.22475577
66Hypsarrhythmia (HP:0002521)2.21369769
67Stereotypic behavior (HP:0000733)2.16733096
68Impaired smooth pursuit (HP:0007772)2.14634342
69Agitation (HP:0000713)2.13448090
70Generalized myoclonic seizures (HP:0002123)2.12794098
71Tetraplegia (HP:0002445)2.12267819
72Ventricular fibrillation (HP:0001663)2.09282404
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.08122999
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08122999
75Hepatoblastoma (HP:0002884)2.06336291
76Absent speech (HP:0001344)2.05626198
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04470008
78Insomnia (HP:0100785)2.04281708
79Neuroendocrine neoplasm (HP:0100634)2.03905112
80Status epilepticus (HP:0002133)2.03820343
81Peripheral hypomyelination (HP:0007182)2.01791450
82Abnormality of the labia minora (HP:0012880)1.99578960
83Aplasia involving bones of the upper limbs (HP:0009823)1.98104778
84Aplasia of the phalanges of the hand (HP:0009802)1.98104778
85Aplasia involving bones of the extremities (HP:0009825)1.98104778
86Spastic tetraplegia (HP:0002510)1.97277696
87Failure to thrive in infancy (HP:0001531)1.95934777
88Retinal dysplasia (HP:0007973)1.94555550
89Craniofacial dystonia (HP:0012179)1.94469661
90Apathy (HP:0000741)1.92681674
91Psychosis (HP:0000709)1.91624627
92Morphological abnormality of the pyramidal tract (HP:0002062)1.89437071
93Impaired vibratory sensation (HP:0002495)1.87907558
94Gait ataxia (HP:0002066)1.87273482
95Abnormality of ocular smooth pursuit (HP:0000617)1.86513670
96Alacrima (HP:0000522)1.86505512
97Clonus (HP:0002169)1.84676420
98Rapidly progressive (HP:0003678)1.84048451
99Neuronal loss in central nervous system (HP:0002529)1.83686228
100CNS hypomyelination (HP:0003429)1.82625016
101Blue irides (HP:0000635)1.81881872
102Morphological abnormality of the inner ear (HP:0011390)1.80527497
103Hypoventilation (HP:0002791)1.80382359
104Delusions (HP:0000746)1.78021755
105Annular pancreas (HP:0001734)1.77942978
106Turricephaly (HP:0000262)1.77763114
107Hypoplasia of the corpus callosum (HP:0002079)1.77465445
108Postural tremor (HP:0002174)1.76822495
109Specific learning disability (HP:0001328)1.76680056
110Inability to walk (HP:0002540)1.75883467
111Sleep apnea (HP:0010535)1.75614785
112Pointed chin (HP:0000307)1.74936784
113Incomplete penetrance (HP:0003829)1.74817135
114Increased circulating renin level (HP:0000848)1.74469737
115Type II lissencephaly (HP:0007260)1.74222181
116Gait imbalance (HP:0002141)1.71719141
117Bronchomalacia (HP:0002780)1.69989092
118Spinal canal stenosis (HP:0003416)1.69132750
119Poor suck (HP:0002033)1.69094867
120Diminished motivation (HP:0000745)1.67960048
121Lower limb asymmetry (HP:0100559)1.67076601
122Thickened helices (HP:0000391)1.66299345
123Shallow orbits (HP:0000586)1.63235606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.38213144
2EPHA44.19429515
3MAP3K93.50855246
4MAP3K43.11038639
5MARK12.94180210
6MINK12.60547550
7MAP2K72.47144842
8PRKD32.45021265
9NTRK22.26238673
10PAK62.23708262
11DAPK22.11499813
12KSR22.05581367
13NTRK11.99002866
14PNCK1.94632772
15MAP2K41.79974661
16MAP3K121.78111069
17ARAF1.63997188
18CAMKK11.61826593
19CASK1.58847952
20CDK51.57369105
21PRPF4B1.57210665
22TNIK1.52752278
23KSR11.52589246
24RIPK41.48529271
25PLK21.46458507
26UHMK11.44167078
27TYRO31.33591666
28CDK191.32222379
29MAPK131.31945829
30MAP3K21.30408876
31DYRK21.26017078
32GRK51.25864592
33SIK21.23897081
34PRKCG1.23136145
35MAP3K131.19205900
36FES1.15542354
37DAPK11.13069830
38SGK4941.11059299
39SGK2231.11059299
40STK381.09372467
41CAMK2A1.09268904
42PHKG11.07967832
43PHKG21.07967832
44LATS21.00331254
45PAK30.99430129
46OXSR10.98295922
47CDK140.97534778
48RIPK10.96418862
49CAMK2B0.95383498
50CDK150.94551289
51CDK180.94514979
52FGFR20.91320473
53PRKCH0.87351548
54CAMKK20.87278692
55BRSK10.83646460
56LMTK20.83359209
57CDK11A0.81980798
58CAMK10.81338590
59STK110.80928121
60PINK10.78330079
61BMPR20.78265288
62SGK20.76887816
63RET0.74768089
64PTK2B0.73783484
65CAMK40.73454311
66TAOK10.72139550
67NME10.71702479
68ALK0.69320053
69RAF10.69080901
70STK390.68489759
71DYRK1A0.68153201
72CSNK1G20.67830247
73SGK10.67333734
74ROCK20.67313634
75CAMK2D0.64809454
76CAMK2G0.64594162
77SGK30.64138260
78WNK10.60454490
79PRKCE0.60228269
80MAP3K10.58959653
81MARK20.58246447
82PDPK10.56226969
83CAMK1G0.54288826
84PRKCZ0.53839303
85FER0.53039035
86ERBB20.52621130
87TNK20.52532565
88PKN10.52229770
89BRAF0.50615221
90PDK10.50522744
91NEK60.49914689
92DYRK1B0.49525163
93LIMK10.49498669
94BCR0.49346061
95FGR0.49284956
96CDC42BPA0.48859376
97RPS6KA30.47154518
98MAPK100.46937289
99DDR20.45261199
100WNK30.45134471
101FYN0.44739145
102CSNK1G30.43565323
103MAP2K10.42882385
104ROCK10.42026922
105MOS0.41643843
106WNK40.41501184
107CSNK1E0.40718684
108MAPK120.39398437
109MUSK0.39306822
110DAPK30.38870572
111DMPK0.38679927
112CSNK1D0.36411855
113EPHB20.35537504
114PRKG10.35416338
115CSNK1G10.35246235
116CSNK1A1L0.33802197
117PRKACA0.30782454
118PRKDC0.30493484
119MAPK80.30162301
120GSK3B0.29783926
121CSNK1A10.29129619
122PDGFRA0.28154702
123PRKCA0.27049687
124MAPKAPK50.26323511
125CDK30.24824730

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69469787
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22285357
3GABAergic synapse_Homo sapiens_hsa047272.81879808
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64274131
5Long-term potentiation_Homo sapiens_hsa047202.60464011
6Circadian entrainment_Homo sapiens_hsa047132.60055078
7Olfactory transduction_Homo sapiens_hsa047402.57029876
8Glutamatergic synapse_Homo sapiens_hsa047242.56384766
9Morphine addiction_Homo sapiens_hsa050322.45592066
10Amphetamine addiction_Homo sapiens_hsa050312.41547310
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22603462
12Dopaminergic synapse_Homo sapiens_hsa047282.15590196
13Salivary secretion_Homo sapiens_hsa049702.06801097
14Insulin secretion_Homo sapiens_hsa049112.00107277
15Gastric acid secretion_Homo sapiens_hsa049711.91612984
16Cholinergic synapse_Homo sapiens_hsa047251.87615278
17Long-term depression_Homo sapiens_hsa047301.79203684
18Cocaine addiction_Homo sapiens_hsa050301.77088079
19Serotonergic synapse_Homo sapiens_hsa047261.77011637
20Taste transduction_Homo sapiens_hsa047421.74586334
21Vitamin B6 metabolism_Homo sapiens_hsa007501.73744929
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72073861
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71818459
24Renin secretion_Homo sapiens_hsa049241.65073106
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61642988
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57881084
27Collecting duct acid secretion_Homo sapiens_hsa049661.56888518
28Calcium signaling pathway_Homo sapiens_hsa040201.49016254
29GnRH signaling pathway_Homo sapiens_hsa049121.42402624
30Gap junction_Homo sapiens_hsa045401.42190106
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29810056
32Axon guidance_Homo sapiens_hsa043601.25859405
33Nitrogen metabolism_Homo sapiens_hsa009101.23794305
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22745375
35cAMP signaling pathway_Homo sapiens_hsa040241.22263832
36Cardiac muscle contraction_Homo sapiens_hsa042601.19529189
37Estrogen signaling pathway_Homo sapiens_hsa049151.13907996
38Melanogenesis_Homo sapiens_hsa049161.13573243
39Vibrio cholerae infection_Homo sapiens_hsa051101.12018388
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11280414
41Glioma_Homo sapiens_hsa052141.08830363
42Type II diabetes mellitus_Homo sapiens_hsa049301.08755534
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08014143
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05727869
45ErbB signaling pathway_Homo sapiens_hsa040121.01407151
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98404662
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97924306
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.92242959
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.85796575
50Dorso-ventral axis formation_Homo sapiens_hsa043200.84903174
51Hippo signaling pathway_Homo sapiens_hsa043900.83485387
52Oocyte meiosis_Homo sapiens_hsa041140.83164162
53Pancreatic secretion_Homo sapiens_hsa049720.82339146
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82292445
55Thyroid hormone synthesis_Homo sapiens_hsa049180.77498448
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76685758
57Dilated cardiomyopathy_Homo sapiens_hsa054140.76169746
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74552553
59Alzheimers disease_Homo sapiens_hsa050100.72792493
60Choline metabolism in cancer_Homo sapiens_hsa052310.72784671
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71528020
62Phototransduction_Homo sapiens_hsa047440.71078057
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69728400
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66844468
65MAPK signaling pathway_Homo sapiens_hsa040100.66200567
66Oxidative phosphorylation_Homo sapiens_hsa001900.64810754
67Basal cell carcinoma_Homo sapiens_hsa052170.60134470
68Arginine and proline metabolism_Homo sapiens_hsa003300.59757846
69Type I diabetes mellitus_Homo sapiens_hsa049400.59359222
70Ras signaling pathway_Homo sapiens_hsa040140.58198179
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57971878
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57102719
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56879370
74Alcoholism_Homo sapiens_hsa050340.56654562
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.55740000
76Prion diseases_Homo sapiens_hsa050200.55347293
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.54414976
78VEGF signaling pathway_Homo sapiens_hsa043700.53182175
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52525906
80Glucagon signaling pathway_Homo sapiens_hsa049220.52498790
81Parkinsons disease_Homo sapiens_hsa050120.52006036
82Rap1 signaling pathway_Homo sapiens_hsa040150.50828900
83Steroid biosynthesis_Homo sapiens_hsa001000.50611128
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50581729
85Wnt signaling pathway_Homo sapiens_hsa043100.49322225
86Renal cell carcinoma_Homo sapiens_hsa052110.49153675
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48405397
88Bile secretion_Homo sapiens_hsa049760.46133385
89Endocytosis_Homo sapiens_hsa041440.46030782
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44280774
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42946746
92Fatty acid biosynthesis_Homo sapiens_hsa000610.42787116
93Tight junction_Homo sapiens_hsa045300.42113648
94Histidine metabolism_Homo sapiens_hsa003400.41481005
95beta-Alanine metabolism_Homo sapiens_hsa004100.41288218
96Butanoate metabolism_Homo sapiens_hsa006500.40919295
97Ovarian steroidogenesis_Homo sapiens_hsa049130.40392449
98Endometrial cancer_Homo sapiens_hsa052130.38351765
99mTOR signaling pathway_Homo sapiens_hsa041500.37459769
100Non-small cell lung cancer_Homo sapiens_hsa052230.36787102
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35614577
102Insulin signaling pathway_Homo sapiens_hsa049100.35361617
103Inositol phosphate metabolism_Homo sapiens_hsa005620.34821770
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34695391
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33925636
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33025172
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31905595
108AMPK signaling pathway_Homo sapiens_hsa041520.31844717
109Arginine biosynthesis_Homo sapiens_hsa002200.31409854
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31330157
111Huntingtons disease_Homo sapiens_hsa050160.30490043
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30386988
113Hedgehog signaling pathway_Homo sapiens_hsa043400.29552676
114Circadian rhythm_Homo sapiens_hsa047100.29000677
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25637801

Most similar genes based on co-expression Upload to Enrichr

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