ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neurotransmitter-gated ion channel clustering (GO:0072578)	5.46679369
2	auditory behavior (GO:0031223)	5.02962466
3	ribonucleoprotein complex disassembly (GO:0032988)	4.66692879
4	positive regulation of mitochondrial fission (GO:0090141)	4.60889445
5	cardiac right ventricle morphogenesis (GO:0003215)	4.55106313
6	C4-dicarboxylate transport (GO:0015740)	4.37781512
7	growth hormone secretion (GO:0030252)	4.09571046
8	metallo-sulfur cluster assembly (GO:0031163)	4.08491122
9	iron-sulfur cluster assembly (GO:0016226)	4.08491122
10	secondary heart field specification (GO:0003139)	4.07687291
11	heart field specification (GO:0003128)	4.07687291
12	GDP-mannose metabolic process (GO:0019673)	3.99996485
13	protein localization to synapse (GO:0035418)	3.98917681
14	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.97687925
15	regulation of cardioblast proliferation (GO:0003264)	3.97687925
16	mannosylation (GO:0097502)	3.91793419
17	GPI anchor biosynthetic process (GO:0006506)	3.88984747
18	nonmotile primary cilium assembly (GO:0035058)	3.86637204
19	organelle disassembly (GO:1903008)	3.85699905
20	gamma-aminobutyric acid transport (GO:0015812)	3.83460017
21	retinal ganglion cell axon guidance (GO:0031290)	3.79268349
22	neuron cell-cell adhesion (GO:0007158)	3.78198435
23	GPI anchor metabolic process (GO:0006505)	3.77686708
24	DNA damage response, detection of DNA damage (GO:0042769)	3.68856497
25	behavioral response to ethanol (GO:0048149)	3.66049981
26	mechanosensory behavior (GO:0007638)	3.65463187
27	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.58610355
28	seminiferous tubule development (GO:0072520)	3.57918653
29	postsynaptic membrane organization (GO:0001941)	3.57431191
30	amine catabolic process (GO:0009310)	3.56351700
31	cellular biogenic amine catabolic process (GO:0042402)	3.56351700
32	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.50326934
33	protein polyglutamylation (GO:0018095)	3.47247303
34	adult feeding behavior (GO:0008343)	3.45664445
35	synaptic vesicle exocytosis (GO:0016079)	3.45527964
36	specification of organ identity (GO:0010092)	3.43101653
37	L-fucose catabolic process (GO:0042355)	3.40996638
38	fucose catabolic process (GO:0019317)	3.40996638
39	L-fucose metabolic process (GO:0042354)	3.40996638
40	pyrimidine nucleobase catabolic process (GO:0006208)	3.37513988
41	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.35687586
42	preassembly of GPI anchor in ER membrane (GO:0016254)	3.35262602
43	regulation of mitochondrial fission (GO:0090140)	3.33154834
44	platelet dense granule organization (GO:0060155)	3.32520029
45	response to auditory stimulus (GO:0010996)	3.28157966
46	presynaptic membrane assembly (GO:0097105)	3.23076205
47	melanosome transport (GO:0032402)	3.22932093
48	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.22826054
49	endocardial cushion morphogenesis (GO:0003203)	3.20511371
50	cellular ketone body metabolic process (GO:0046950)	3.17875323
51	chaperone-mediated protein transport (GO:0072321)	3.16700841
52	positive regulation of TOR signaling (GO:0032008)	3.15123329
53	DNA integration (GO:0015074)	3.13733125
54	regulation of cilium movement (GO:0003352)	3.13586076
55	GTP biosynthetic process (GO:0006183)	3.11302701
56	pigment granule transport (GO:0051904)	3.08818710
57	membrane budding (GO:0006900)	3.07979197
58	establishment of melanosome localization (GO:0032401)	3.07608281
59	C-terminal protein lipidation (GO:0006501)	3.07466434
60	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.06324210
61	spinal cord motor neuron differentiation (GO:0021522)	3.05275553
62	C-terminal protein amino acid modification (GO:0018410)	3.03154333
63	dendritic spine morphogenesis (GO:0060997)	2.97181978
64	synapse assembly (GO:0007416)	2.96241336
65	behavioral response to nicotine (GO:0035095)	2.95653257
66	melanosome localization (GO:0032400)	2.95615054
67	establishment of pigment granule localization (GO:0051905)	2.94774776
68	establishment of mitochondrion localization (GO:0051654)	2.94425894
69	neurotransmitter biosynthetic process (GO:0042136)	2.92697823
70	glycolipid biosynthetic process (GO:0009247)	2.90402094
71	detection of light stimulus involved in visual perception (GO:0050908)	2.89115966
72	detection of light stimulus involved in sensory perception (GO:0050962)	2.89115966
73	innervation (GO:0060384)	2.87447727
74	dicarboxylic acid catabolic process (GO:0043649)	2.85494210
75	protein localization to cilium (GO:0061512)	2.84871140
76	vocalization behavior (GO:0071625)	2.84824664
77	pigment granule localization (GO:0051875)	2.84287959
78	nucleobase catabolic process (GO:0046113)	2.81301682
79	presynaptic membrane organization (GO:0097090)	2.81012492
80	ketone body metabolic process (GO:1902224)	2.79965349
81	cell differentiation in spinal cord (GO:0021515)	2.78551142
82	acidic amino acid transport (GO:0015800)	2.77934637
83	carnitine metabolic process (GO:0009437)	2.77781305
84	polyamine metabolic process (GO:0006595)	2.76494871
85	glycerophospholipid catabolic process (GO:0046475)	2.75432162
86	parturition (GO:0007567)	2.73232336
87	opioid receptor signaling pathway (GO:0038003)	2.72531583
88	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.72149987
89	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.72149987
90	NADH dehydrogenase complex assembly (GO:0010257)	2.72149987
91	cilium morphogenesis (GO:0060271)	2.70671451
92	response to dietary excess (GO:0002021)	2.68517758
93	protein-cofactor linkage (GO:0018065)	2.62399061
94	cranial nerve development (GO:0021545)	2.61931964
95	epithelial cilium movement (GO:0003351)	2.60582694
96	head development (GO:0060322)	2.58201408
97	UTP biosynthetic process (GO:0006228)	2.56855222
98	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.53691643
99	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.53691643
100	L-glutamate transport (GO:0015813)	2.53454805

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.63971484
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.45943907
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.76643157
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45859015
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.42657522
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.21352135
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.20515398
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.10100830
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.03121782
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.96251573
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.83454709
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45389089
13	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.35147783
14	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.14626572
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.13456236
16	DCP1A_22483619_ChIP-Seq_HELA_Human	2.10604500
17	GBX2_23144817_ChIP-Seq_PC3_Human	2.05019885
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99621598
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.97422868
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.92602804
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.91981070
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91166210
23	CIITA_25753668_ChIP-Seq_RAJI_Human	1.85518640
24	GABP_19822575_ChIP-Seq_HepG2_Human	1.82402565
25	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.82175996
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.79301611
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.77828572
28	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.75552577
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.72170796
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.70495441
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.69545759
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.67890596
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.67231977
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.61901442
35	EZH2_22144423_ChIP-Seq_EOC_Human	1.61673684
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.61023064
37	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.60521466
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57831891
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56391536
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.48675824
41	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.47429361
42	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.46670362
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.41762030
44	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.36959981
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35297681
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.33023849
47	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.32783025
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32411768
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.30014799
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30014799
51	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28723129
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25403098
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17341470
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17153613
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16779875
56	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.16278245
57	P300_19829295_ChIP-Seq_ESCs_Human	1.15185728
58	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.12747445
59	XRN2_22483619_ChIP-Seq_HELA_Human	1.12401895
60	HTT_18923047_ChIP-ChIP_STHdh_Human	1.11224783
61	ERA_21632823_ChIP-Seq_H3396_Human	1.09953247
62	NCOR_22424771_ChIP-Seq_293T_Human	1.09917992
63	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.08845210
64	TTF2_22483619_ChIP-Seq_HELA_Human	1.07393905
65	EGR1_19032775_ChIP-ChIP_M12_Human	1.07206566
66	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.05480459
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05227805
68	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.03614752
69	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02270078
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.01799827
71	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.01335572
72	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.01241411
73	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00741061
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.00524413
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97104179
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.96292180
77	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95769955
78	RAC3_21632823_ChIP-Seq_H3396_Human	0.95726402
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94294750
80	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.93623353
81	KDM5A_27292631_Chip-Seq_BREAST_Human	0.92491385
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.90808798
83	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88958432
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88535705
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87973056
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.87944993
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83639319
88	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.83085653
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.82293849
90	VDR_22108803_ChIP-Seq_LS180_Human	0.81903009
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.81673879
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.81587583
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.80658830
94	PHF8_20622854_ChIP-Seq_HELA_Human	0.80505858
95	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.79554664
96	RNF2_27304074_Chip-Seq_NSC_Mouse	0.77761618
97	ER_23166858_ChIP-Seq_MCF-7_Human	0.77610339
98	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.77138144
99	BCL6_27268052_Chip-Seq_Bcells_Human	0.76587698
100	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.76262163

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	4.81494459
2	MP0001529_abnormal_vocalization	3.64470165
3	MP0002102_abnormal_ear_morphology	3.64388137
4	MP0006072_abnormal_retinal_apoptosis	3.49070285
5	MP0006276_abnormal_autonomic_nervous	3.33226762
6	MP0004859_abnormal_synaptic_plasticity	3.24651772
7	MP0005394_taste/olfaction_phenotype	2.91317428
8	MP0005499_abnormal_olfactory_system	2.91317428
9	MP0001986_abnormal_taste_sensitivity	2.64429307
10	MP0003880_abnormal_central_pattern	2.63529792
11	MP0008789_abnormal_olfactory_epithelium	2.62465705
12	MP0005645_abnormal_hypothalamus_physiol	2.60973084
13	MP0008995_early_reproductive_senescence	2.46039806
14	MP0004270_analgesia	2.26336046
15	MP0002735_abnormal_chemical_nociception	2.25290739
16	MP0001984_abnormal_olfaction	2.17925763
17	MP0001968_abnormal_touch/_nociception	2.11126949
18	MP0002751_abnormal_autonomic_nervous	2.00165566
19	MP0005646_abnormal_pituitary_gland	1.89672791
20	MP0005253_abnormal_eye_physiology	1.87280115
21	MP0005423_abnormal_somatic_nervous	1.80686334
22	MP0009046_muscle_twitch	1.76739103
23	MP0009745_abnormal_behavioral_response	1.67228711
24	MP0005551_abnormal_eye_electrophysiolog	1.67214564
25	MP0000049_abnormal_middle_ear	1.66851844
26	MP0003635_abnormal_synaptic_transmissio	1.65464052
27	MP0001486_abnormal_startle_reflex	1.59835890
28	MP0000631_abnormal_neuroendocrine_gland	1.54938747
29	MP0002272_abnormal_nervous_system	1.45846250
30	MP0002234_abnormal_pharynx_morphology	1.43380621
31	MP0000750_abnormal_muscle_regeneration	1.43037136
32	MP0000778_abnormal_nervous_system	1.42174394
33	MP0002733_abnormal_thermal_nociception	1.42156650
34	MP0002572_abnormal_emotion/affect_behav	1.41485521
35	MP0006035_abnormal_mitochondrial_morpho	1.40789008
36	MP0002063_abnormal_learning/memory/cond	1.37398354
37	MP0004885_abnormal_endolymph	1.36031140
38	MP0003137_abnormal_impulse_conducting	1.33658233
39	MP0002734_abnormal_mechanical_nocicepti	1.33186568
40	MP0002653_abnormal_ependyma_morphology	1.32879670
41	MP0005171_absent_coat_pigmentation	1.32667357
42	MP0000013_abnormal_adipose_tissue	1.28380075
43	MP0001905_abnormal_dopamine_level	1.28013247
44	MP0004924_abnormal_behavior	1.24264521
45	MP0005386_behavior/neurological_phenoty	1.24264521
46	MP0002752_abnormal_somatic_nervous	1.21640275
47	MP0002184_abnormal_innervation	1.18916179
48	MP0000026_abnormal_inner_ear	1.17894193
49	MP0003879_abnormal_hair_cell	1.14748074
50	MP0004142_abnormal_muscle_tone	1.14612801
51	MP0002095_abnormal_skin_pigmentation	1.12695898
52	MP0005167_abnormal_blood-brain_barrier	1.11304383
53	MP0004133_heterotaxia	1.10228061
54	MP0002557_abnormal_social/conspecific_i	1.09604536
55	MP0002064_seizures	1.08176655
56	MP0001970_abnormal_pain_threshold	1.05447564
57	MP0001270_distended_abdomen	1.05027987
58	MP0002882_abnormal_neuron_morphology	1.04211809
59	MP0003938_abnormal_ear_development	1.04190337
60	MP0003221_abnormal_cardiomyocyte_apopto	1.03895584
61	MP0004043_abnormal_pH_regulation	1.03210086
62	MP0001502_abnormal_circadian_rhythm	1.02104163
63	MP0000681_abnormal_thyroid_gland	1.00949555
64	MP0000955_abnormal_spinal_cord	0.97061225
65	MP0003122_maternal_imprinting	0.96777237
66	MP0003567_abnormal_fetal_cardiomyocyte	0.95750561
67	MP0002233_abnormal_nose_morphology	0.94204556
68	MP0002229_neurodegeneration	0.93808019
69	MP0005391_vision/eye_phenotype	0.93272072
70	MP0008058_abnormal_DNA_repair	0.91722189
71	MP0002069_abnormal_eating/drinking_beha	0.91697164
72	MP0003011_delayed_dark_adaptation	0.88433719
73	MP0001764_abnormal_homeostasis	0.88272562
74	MP0002736_abnormal_nociception_after	0.87863615
75	MP0002876_abnormal_thyroid_physiology	0.87367385
76	MP0004811_abnormal_neuron_physiology	0.87024430
77	MP0005195_abnormal_posterior_eye	0.86295398
78	MP0001963_abnormal_hearing_physiology	0.83355730
79	MP0002638_abnormal_pupillary_reflex	0.81813418
80	MP0001664_abnormal_digestion	0.78981537
81	MP0003786_premature_aging	0.77231975
82	MP0002067_abnormal_sensory_capabilities	0.77204845
83	MP0001485_abnormal_pinna_reflex	0.77142966
84	MP0000427_abnormal_hair_cycle	0.76508207
85	MP0005220_abnormal_exocrine_pancreas	0.74819923
86	MP0001293_anophthalmia	0.74079533
87	MP0003121_genomic_imprinting	0.73309824
88	MP0003718_maternal_effect	0.73048650
89	MP0008569_lethality_at_weaning	0.73029542
90	MP0003136_yellow_coat_color	0.72829693
91	MP0006292_abnormal_olfactory_placode	0.68442283
92	MP0008875_abnormal_xenobiotic_pharmacok	0.67874412
93	MP0005187_abnormal_penis_morphology	0.67438173
94	MP0001188_hyperpigmentation	0.66863546
95	MP0000613_abnormal_salivary_gland	0.66548896
96	MP0001501_abnormal_sleep_pattern	0.66203495
97	MP0002066_abnormal_motor_capabilities/c	0.66053584
98	MP0004085_abnormal_heartbeat	0.65628466
99	MP0002177_abnormal_outer_ear	0.65431408
100	MP0002249_abnormal_larynx_morphology	0.63366927

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gait imbalance (HP:0002141)	3.94838435
2	Nephrogenic diabetes insipidus (HP:0009806)	3.90584679
3	Congenital primary aphakia (HP:0007707)	3.86020019
4	Acute necrotizing encephalopathy (HP:0006965)	3.73631467
5	Hepatocellular necrosis (HP:0001404)	3.59278903
6	Medial flaring of the eyebrow (HP:0010747)	3.51702868
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.48866334
8	Tubulointerstitial nephritis (HP:0001970)	3.36657303
9	Mitochondrial inheritance (HP:0001427)	3.36638346
10	Hepatic necrosis (HP:0002605)	3.21905176
11	Increased intramyocellular lipid droplets (HP:0012240)	3.21269066
12	Acute encephalopathy (HP:0006846)	3.13696646
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.11852209
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.11852209
15	True hermaphroditism (HP:0010459)	3.08086104
16	Progressive macrocephaly (HP:0004481)	2.97871619
17	Ankle clonus (HP:0011448)	2.94615034
18	Pancreatic fibrosis (HP:0100732)	2.85067966
19	Increased CSF lactate (HP:0002490)	2.83547459
20	Intestinal atresia (HP:0011100)	2.81431608
21	Methylmalonic acidemia (HP:0002912)	2.81319491
22	Increased hepatocellular lipid droplets (HP:0006565)	2.79899601
23	Sclerocornea (HP:0000647)	2.77675290
24	Pancreatic cysts (HP:0001737)	2.75309230
25	Hemiparesis (HP:0001269)	2.73033247
26	Increased muscle lipid content (HP:0009058)	2.70106497
27	Vaginal atresia (HP:0000148)	2.67922933
28	Lipid accumulation in hepatocytes (HP:0006561)	2.66388844
29	Genital tract atresia (HP:0001827)	2.62709349
30	Renal cortical cysts (HP:0000803)	2.57364530
31	Cortical dysplasia (HP:0002539)	2.53408954
32	Gonadotropin excess (HP:0000837)	2.53195920
33	Split foot (HP:0001839)	2.52419468
34	Thyroid-stimulating hormone excess (HP:0002925)	2.50833537
35	Cerebral edema (HP:0002181)	2.50660648
36	Retinal dysplasia (HP:0007973)	2.45915936
37	Occipital encephalocele (HP:0002085)	2.45874082
38	Myokymia (HP:0002411)	2.45467574
39	Spastic gait (HP:0002064)	2.40687652
40	Poor coordination (HP:0002370)	2.40415602
41	Esotropia (HP:0000565)	2.40103508
42	Cerebellar dysplasia (HP:0007033)	2.39684941
43	Anterior segment dysgenesis (HP:0007700)	2.38761718
44	Polyphagia (HP:0002591)	2.37335062
45	Cerebral hypomyelination (HP:0006808)	2.35723286
46	Methylmalonic aciduria (HP:0012120)	2.35720226
47	Pendular nystagmus (HP:0012043)	2.32754350
48	Broad foot (HP:0001769)	2.31256060
49	Specific learning disability (HP:0001328)	2.31214499
50	Nephronophthisis (HP:0000090)	2.27985080
51	Failure to thrive in infancy (HP:0001531)	2.27586869
52	Renal Fanconi syndrome (HP:0001994)	2.24859634
53	Increased serum pyruvate (HP:0003542)	2.24345295
54	Type II lissencephaly (HP:0007260)	2.23556261
55	Increased serum lactate (HP:0002151)	2.23529109
56	Type I transferrin isoform profile (HP:0003642)	2.22734852
57	Molar tooth sign on MRI (HP:0002419)	2.22556754
58	Abnormality of midbrain morphology (HP:0002418)	2.22556754
59	Inability to walk (HP:0002540)	2.22113526
60	Lissencephaly (HP:0001339)	2.21367095
61	Cystic liver disease (HP:0006706)	2.19491247
62	Abnormality of glycolysis (HP:0004366)	2.16677284
63	Drooling (HP:0002307)	2.16072991
64	Decreased testicular size (HP:0008734)	2.15531683
65	Optic nerve hypoplasia (HP:0000609)	2.15251138
66	Microvesicular hepatic steatosis (HP:0001414)	2.13475564
67	Agitation (HP:0000713)	2.13206717
68	Emotional lability (HP:0000712)	2.11867279
69	Alacrima (HP:0000522)	2.10554581
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09514461
71	Abnormal protein N-linked glycosylation (HP:0012347)	2.09514461
72	Abnormal protein glycosylation (HP:0012346)	2.09514461
73	Abnormal glycosylation (HP:0012345)	2.09514461
74	Lactic acidosis (HP:0003128)	2.07883111
75	Aplasia/Hypoplasia of the lens (HP:0008063)	2.06799392
76	Exercise intolerance (HP:0003546)	2.04438012
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04180003
78	Aplastic anemia (HP:0001915)	2.01551242
79	Abnormality of the anterior horn cell (HP:0006802)	2.01356905
80	Degeneration of anterior horn cells (HP:0002398)	2.01356905
81	Severe muscular hypotonia (HP:0006829)	1.99193014
82	Epileptic encephalopathy (HP:0200134)	1.98770707
83	Excessive salivation (HP:0003781)	1.98625396
84	Spastic tetraplegia (HP:0002510)	1.97329933
85	Short tibia (HP:0005736)	1.96860655
86	Decreased lacrimation (HP:0000633)	1.95085392
87	Hypothermia (HP:0002045)	1.93364644
88	Hemiplegia (HP:0002301)	1.92296886
89	Abnormality of the renal medulla (HP:0100957)	1.91851157
90	Neonatal respiratory distress (HP:0002643)	1.90266758
91	Postaxial foot polydactyly (HP:0001830)	1.89556893
92	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.89249516
93	Tented upper lip vermilion (HP:0010804)	1.86347147
94	Delayed CNS myelination (HP:0002188)	1.85904268
95	Lower limb muscle weakness (HP:0007340)	1.85767596
96	Abnormality of fatty-acid metabolism (HP:0004359)	1.79958544
97	Abolished electroretinogram (ERG) (HP:0000550)	1.79464657
98	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78230015
99	Postaxial hand polydactyly (HP:0001162)	1.77218106
100	Absent speech (HP:0001344)	1.76289478

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.88799630
2	BCKDK	4.13633082
3	CASK	3.48873005
4	EPHA3	3.31326272
5	MAP4K2	3.22552768
6	MAP2K7	2.99520596
7	MAP3K4	2.80298124
8	MARK1	2.64894526
9	BCR	2.58124105
10	TRIM28	2.38464816
11	ADRBK2	2.30313074
12	SRPK1	2.17699792
13	CSNK1A1L	2.12333165
14	CSNK1G3	2.04858195
15	EPHB1	1.96551352
16	TAOK3	1.90901489
17	WNK3	1.87201688
18	TESK2	1.87075034
19	PAK6	1.84293422
20	CSNK1G2	1.78535280
21	AKT3	1.66915087
22	CSNK1G1	1.55899474
23	PINK1	1.45214245
24	DYRK2	1.44835585
25	PIM2	1.39358932
26	TESK1	1.38861882
27	RPS6KA4	1.35733580
28	MAPK13	1.29323097
29	DYRK1B	1.23059549
30	ZAK	1.21574855
31	LIMK1	1.21172106
32	PAK3	1.18385283
33	SCYL2	1.16697969
34	CDK19	1.16520812
35	NEK9	1.15386509
36	SIK2	1.11558764
37	NME1	1.10653017
38	VRK2	1.10103724
39	VRK1	1.07347828
40	ERBB3	1.01654390
41	NTRK2	0.98907250
42	PRKCE	0.98208369
43	OXSR1	0.97818913
44	PRKD3	0.95778254
45	SIK3	0.92324647
46	RPS6KA5	0.92223799
47	DYRK3	0.91857531
48	TNK2	0.88444800
49	MAP2K4	0.86735355
50	CAMK2A	0.79805748
51	MATK	0.78128751
52	GRK7	0.73612001
53	EIF2AK3	0.72351486
54	TLK1	0.71594828
55	CSNK1A1	0.71517896
56	DDR2	0.66929245
57	KDR	0.65548829
58	EPHA4	0.65274281
59	CDK5	0.64262821
60	CDK14	0.63040631
61	UHMK1	0.59674240
62	GRK1	0.59017966
63	CDK18	0.58909661
64	CLK1	0.57643628
65	CCNB1	0.56057193
66	MAP3K5	0.55349592
67	PRKCG	0.54353643
68	CDK15	0.52096444
69	CAMK2D	0.51496210
70	CAMK2G	0.51494585
71	DYRK1A	0.50380968
72	CAMK2B	0.48998891
73	CDK11A	0.48086633
74	AKT2	0.47065817
75	AURKA	0.43587920
76	TSSK6	0.43244003
77	STK38L	0.42660856
78	FRK	0.42197659
79	ADRBK1	0.41275478
80	PRKACA	0.37587710
81	KSR1	0.37434490
82	NUAK1	0.37424598
83	PRKAA1	0.36501081
84	DAPK2	0.36214517
85	MINK1	0.34150743
86	RAF1	0.33309672
87	STK24	0.32808430
88	CAMK4	0.31343348
89	PRKACB	0.31188754
90	CDK9	0.29450183
91	PRKG1	0.28864936
92	INSRR	0.28541482
93	ERBB4	0.27198753
94	MAPKAPK5	0.27158449
95	DAPK3	0.26043512
96	PRKACG	0.25011257
97	EGFR	0.23457724
98	BMPR1B	0.22572124
99	PRKCA	0.22474236
100	ATM	0.20772246

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.20849261
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.58859096
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.85140331
4	Nicotine addiction_Homo sapiens_hsa05033	2.82435681
5	Parkinsons disease_Homo sapiens_hsa05012	2.22865125
6	RNA polymerase_Homo sapiens_hsa03020	2.17928534
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15392377
8	Protein export_Homo sapiens_hsa03060	2.14220192
9	GABAergic synapse_Homo sapiens_hsa04727	2.06994780
10	Butanoate metabolism_Homo sapiens_hsa00650	2.05283242
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.89199614
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88164490
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85001727
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82635987
15	Peroxisome_Homo sapiens_hsa04146	1.81520557
16	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.77862307
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74088744
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.72022392
19	beta-Alanine metabolism_Homo sapiens_hsa00410	1.69545271
20	Fatty acid elongation_Homo sapiens_hsa00062	1.67944565
21	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.64401725
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.51285716
23	Huntingtons disease_Homo sapiens_hsa05016	1.49480547
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48359080
25	Base excision repair_Homo sapiens_hsa03410	1.47641882
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.45865123
27	Propanoate metabolism_Homo sapiens_hsa00640	1.42988096
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.40676353
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39047054
30	Phototransduction_Homo sapiens_hsa04744	1.38988739
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36142381
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28203302
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25251870
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.24173624
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.23460367
36	Basal transcription factors_Homo sapiens_hsa03022	1.20341129
37	Morphine addiction_Homo sapiens_hsa05032	1.19530610
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.19023436
39	Spliceosome_Homo sapiens_hsa03040	1.17551944
40	Sulfur relay system_Homo sapiens_hsa04122	1.15731151
41	Taste transduction_Homo sapiens_hsa04742	1.10732571
42	Serotonergic synapse_Homo sapiens_hsa04726	1.06854414
43	Alcoholism_Homo sapiens_hsa05034	1.04927033
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.00188156
45	Caffeine metabolism_Homo sapiens_hsa00232	0.99147497
46	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.98775161
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98651377
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.98582890
49	Alzheimers disease_Homo sapiens_hsa05010	0.97122500
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96299284
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.95852696
52	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.95246683
53	Olfactory transduction_Homo sapiens_hsa04740	0.93778104
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.91614924
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.89160789
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.86387079
57	Proteasome_Homo sapiens_hsa03050	0.85093551
58	Purine metabolism_Homo sapiens_hsa00230	0.85021040
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83140170
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82129679
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.81093600
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80138696
63	Circadian entrainment_Homo sapiens_hsa04713	0.79587581
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79560252
65	Metabolic pathways_Homo sapiens_hsa01100	0.78279063
66	Cocaine addiction_Homo sapiens_hsa05030	0.77863872
67	ABC transporters_Homo sapiens_hsa02010	0.74617878
68	Histidine metabolism_Homo sapiens_hsa00340	0.73176494
69	Long-term depression_Homo sapiens_hsa04730	0.69862814
70	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.65222266
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.63350425
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.63309598
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60901558
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60125116
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59420518
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58390264
77	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57549255
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56519325
79	Sulfur metabolism_Homo sapiens_hsa00920	0.52547337
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.51839826
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.50737407
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50580477
83	Carbon metabolism_Homo sapiens_hsa01200	0.49458519
84	Insulin secretion_Homo sapiens_hsa04911	0.48940962
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47708409
86	RNA transport_Homo sapiens_hsa03013	0.46946707
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.46270181
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41267861
89	RNA degradation_Homo sapiens_hsa03018	0.38442169
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.38115366
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38074257
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35272988
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33655721
94	Axon guidance_Homo sapiens_hsa04360	0.32222756
95	Retinol metabolism_Homo sapiens_hsa00830	0.32025483
96	Homologous recombination_Homo sapiens_hsa03440	0.31947920
97	Arginine biosynthesis_Homo sapiens_hsa00220	0.30972431
98	Regulation of autophagy_Homo sapiens_hsa04140	0.30406805
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.28721694
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.26944345

FAM201B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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