ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	centriole assembly (GO:0098534)	6.05906226
2	histone H3-K9 methylation (GO:0051567)	5.48010375
3	histone H3-K9 modification (GO:0061647)	5.15510208
4	ubiquinone biosynthetic process (GO:0006744)	4.66133441
5	peptidyl-histidine modification (GO:0018202)	4.53096807
6	sensory perception of smell (GO:0007608)	4.42165159
7	protein prenylation (GO:0018342)	4.39951275
8	prenylation (GO:0097354)	4.39951275
9	ubiquinone metabolic process (GO:0006743)	4.26443446
10	cAMP catabolic process (GO:0006198)	4.20533037
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.16690707
12	cyclic nucleotide catabolic process (GO:0009214)	3.99907516
13	quinone biosynthetic process (GO:1901663)	3.98240892
14	epithelial cilium movement (GO:0003351)	3.76760807
15	negative regulation of Ras GTPase activity (GO:0034261)	3.76426793
16	cell proliferation in forebrain (GO:0021846)	3.74739669
17	sphingomyelin metabolic process (GO:0006684)	3.63755704
18	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.58259285
19	inositol phosphate dephosphorylation (GO:0046855)	3.58259285
20	reciprocal meiotic recombination (GO:0007131)	3.48007807
21	reciprocal DNA recombination (GO:0035825)	3.48007807
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.46608611
23	protein K6-linked ubiquitination (GO:0085020)	3.42083569
24	inositol phosphate catabolic process (GO:0071545)	3.31720902
25	replicative senescence (GO:0090399)	3.25308188
26	cilium organization (GO:0044782)	3.22837734
27	secondary metabolite biosynthetic process (GO:0044550)	3.21238904
28	establishment of protein localization to Golgi (GO:0072600)	3.19280824
29	protein targeting to lysosome (GO:0006622)	3.17736681
30	establishment of protein localization to vacuole (GO:0072666)	3.17736681
31	protein targeting to vacuole (GO:0006623)	3.17736681
32	DNA deamination (GO:0045006)	3.15351050
33	intra-S DNA damage checkpoint (GO:0031573)	3.13750722
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.13221651
35	cilium assembly (GO:0042384)	3.11909631
36	behavioral response to nicotine (GO:0035095)	3.09827719
37	forebrain morphogenesis (GO:0048853)	3.09367890
38	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.06988982
39	hepatocyte apoptotic process (GO:0097284)	3.05749013
40	auditory receptor cell differentiation (GO:0042491)	3.02478149
41	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.02334261
42	negative regulation of organelle assembly (GO:1902116)	3.00588694
43	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.99556157
44	negative regulation of B cell proliferation (GO:0030889)	2.98036832
45	cytokine biosynthetic process (GO:0042089)	2.97194647
46	axonal fasciculation (GO:0007413)	2.97021165
47	negative regulation by host of viral transcription (GO:0043922)	2.96582709
48	protein heterotetramerization (GO:0051290)	2.95895765
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.95809461
50	somite development (GO:0061053)	2.95146237
51	protein neddylation (GO:0045116)	2.94630216
52	protein targeting to Golgi (GO:0000042)	2.94371525
53	neural tube formation (GO:0001841)	2.92059760
54	I-kappaB phosphorylation (GO:0007252)	2.88936909
55	ATP synthesis coupled proton transport (GO:0015986)	2.88555427
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.88555427
57	proline transport (GO:0015824)	2.85681281
58	single strand break repair (GO:0000012)	2.85634215
59	retinal cone cell development (GO:0046549)	2.85079511
60	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.84777024
61	otic vesicle formation (GO:0030916)	2.84729723
62	detection of light stimulus involved in visual perception (GO:0050908)	2.84596166
63	detection of light stimulus involved in sensory perception (GO:0050962)	2.84596166
64	dopamine transport (GO:0015872)	2.83554494
65	DNA replication-dependent nucleosome assembly (GO:0006335)	2.83442640
66	DNA replication-dependent nucleosome organization (GO:0034723)	2.83442640
67	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80574325
68	protein localization to lysosome (GO:0061462)	2.79907596
69	protein localization to vacuole (GO:0072665)	2.79907596
70	dentate gyrus development (GO:0021542)	2.76360335
71	parturition (GO:0007567)	2.75774989
72	regulation of protein glycosylation (GO:0060049)	2.75580320
73	microglial cell activation (GO:0001774)	2.75443278
74	mechanoreceptor differentiation (GO:0042490)	2.75112298
75	cellular response to exogenous dsRNA (GO:0071360)	2.73610859
76	negative regulation of T cell mediated immunity (GO:0002710)	2.71927699
77	melanin biosynthetic process (GO:0042438)	2.71155003
78	positive regulation of developmental pigmentation (GO:0048087)	2.70881270
79	positive regulation of interleukin-8 secretion (GO:2000484)	2.67360077
80	interferon-gamma production (GO:0032609)	2.65035396
81	neuron fate determination (GO:0048664)	2.64021144
82	olfactory bulb development (GO:0021772)	2.59843126
83	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.57588015
84	alanine transport (GO:0032328)	2.57146001
85	GTP biosynthetic process (GO:0006183)	2.57083207
86	cilium movement (GO:0003341)	2.54994004
87	nephron tubule morphogenesis (GO:0072078)	2.52655307
88	nephron epithelium morphogenesis (GO:0072088)	2.52655307
89	protein localization to cilium (GO:0061512)	2.51626051
90	positive regulation of cellular response to oxidative stress (GO:1900409)	2.50699353
91	positive regulation of response to oxidative stress (GO:1902884)	2.50699353
92	male meiosis I (GO:0007141)	2.49931588
93	cytokine metabolic process (GO:0042107)	2.49925875
94	regulation of interleukin-8 secretion (GO:2000482)	2.48748550
95	melanin metabolic process (GO:0006582)	2.48726133
96	phosphorelay signal transduction system (GO:0000160)	2.48239870
97	negative regulation of membrane potential (GO:0045837)	2.47929852
98	response to pheromone (GO:0019236)	2.47320169
99	double-strand break repair via homologous recombination (GO:0000724)	2.45445005
100	motile cilium assembly (GO:0044458)	11.2563675

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.76010681
2	VDR_22108803_ChIP-Seq_LS180_Human	3.60207518
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.00529821
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.93860596
5	EWS_26573619_Chip-Seq_HEK293_Human	2.83666307
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.73113214
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67386375
8	FUS_26573619_Chip-Seq_HEK293_Human	2.61296476
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35010807
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30114514
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.21847309
12	P300_19829295_ChIP-Seq_ESCs_Human	2.10954981
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.08207000
14	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.06722068
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04620112
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.03196694
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.99726339
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.98115793
19	CBP_20019798_ChIP-Seq_JUKART_Human	1.98115793
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.96391458
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72056063
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69942367
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63173039
24	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.60422952
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57770287
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57313747
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57064515
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57064515
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.56654182
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.56645406
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.56598476
32	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.55427940
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.55371278
34	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.54658061
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53823660
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50872123
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49407242
38	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.49054439
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49014480
40	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.48573589
41	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.46344143
42	AR_25329375_ChIP-Seq_VCAP_Human	1.45857822
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.45854959
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.45089333
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45006250
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45006250
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.44945952
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44264967
49	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.43043698
50	P53_22387025_ChIP-Seq_ESCs_Mouse	1.42873109
51	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40550681
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39520973
53	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.37804907
54	EZH2_22144423_ChIP-Seq_EOC_Human	1.37764027
55	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.37617571
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37595870
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37065653
58	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.36143486
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36054333
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34391107
61	TCF4_23295773_ChIP-Seq_U87_Human	1.31793703
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31654071
63	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.30534595
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30062885
65	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.29542244
66	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.29255674
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.28068493
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.26906230
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25511000
70	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.25155304
71	VDR_23849224_ChIP-Seq_CD4+_Human	1.25113128
72	STAT3_23295773_ChIP-Seq_U87_Human	1.24810343
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24698087
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24273468
75	TP53_16413492_ChIP-PET_HCT116_Human	1.22116491
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21001247
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20706316
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20521006
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.17880843
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17745655
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17698281
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.16669039
83	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.14569536
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13872717
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13090457
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10882555
87	NCOR_22424771_ChIP-Seq_293T_Human	1.09223279
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08867277
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08860714
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08268209
91	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.08229812
92	AR_20517297_ChIP-Seq_VCAP_Human	1.07622534
93	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06509217
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06332929
95	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.03570877
96	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.03524467
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.03413395
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03152351
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01313970
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01313970

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003123_paternal_imprinting	4.29256145
2	MP0006292_abnormal_olfactory_placode	3.58587727
3	MP0000372_irregular_coat_pigmentation	3.55159869
4	MP0000569_abnormal_digit_pigmentation	3.25650943
5	MP0003787_abnormal_imprinting	3.22914373
6	MP0003121_genomic_imprinting	3.18458477
7	MP0004885_abnormal_endolymph	2.57495936
8	MP0000015_abnormal_ear_pigmentation	2.43601172
9	MP0008877_abnormal_DNA_methylation	2.37422880
10	MP0003136_yellow_coat_color	2.30122859
11	MP0005408_hypopigmentation	2.29135281
12	MP0003890_abnormal_embryonic-extraembry	2.19748905
13	MP0001485_abnormal_pinna_reflex	2.14454833
14	MP0000631_abnormal_neuroendocrine_gland	2.05498222
15	MP0002095_abnormal_skin_pigmentation	2.02437806
16	MP0002735_abnormal_chemical_nociception	1.90111073
17	MP0004145_abnormal_muscle_electrophysio	1.82140896
18	MP0004133_heterotaxia	1.80514241
19	MP0005551_abnormal_eye_electrophysiolog	1.78873184
20	MP0005075_abnormal_melanosome_morpholog	1.71547855
21	MP0002638_abnormal_pupillary_reflex	1.61511784
22	MP0004142_abnormal_muscle_tone	1.53538145
23	MP0001440_abnormal_grooming_behavior	1.52305768
24	MP0005646_abnormal_pituitary_gland	1.51960900
25	MP0000427_abnormal_hair_cycle	1.50332844
26	MP0002928_abnormal_bile_duct	1.48524548
27	MP0005174_abnormal_tail_pigmentation	1.43081889
28	MP0002272_abnormal_nervous_system	1.42411736
29	MP0002396_abnormal_hematopoietic_system	1.42064350
30	MP0000778_abnormal_nervous_system	1.38060767
31	MP0003045_fibrosis	1.36119982
32	MP0001835_abnormal_antigen_presentation	1.33922911
33	MP0002234_abnormal_pharynx_morphology	1.27770309
34	MP0003252_abnormal_bile_duct	1.27257443
35	MP0005253_abnormal_eye_physiology	1.25754415
36	MP0006072_abnormal_retinal_apoptosis	1.25217892
37	MP0005195_abnormal_posterior_eye	1.23056654
38	MP0006276_abnormal_autonomic_nervous	1.19697602
39	MP0001324_abnormal_eye_pigmentation	1.19630204
40	MP0009745_abnormal_behavioral_response	1.18822015
41	MP0002837_dystrophic_cardiac_calcinosis	1.18246433
42	MP0002277_abnormal_respiratory_mucosa	1.17120730
43	MP0005379_endocrine/exocrine_gland_phen	1.16246185
44	MP0001986_abnormal_taste_sensitivity	1.15487708
45	MP0003880_abnormal_central_pattern	1.14108451
46	MP0003195_calcinosis	1.13852989
47	MP0002163_abnormal_gland_morphology	1.12953903
48	MP0001186_pigmentation_phenotype	1.12619847
49	MP0002075_abnormal_coat/hair_pigmentati	1.11867671
50	MP0002160_abnormal_reproductive_system	1.09354687
51	MP0005671_abnormal_response_to	1.06330479
52	MP0004215_abnormal_myocardial_fiber	1.05732564
53	MP0005389_reproductive_system_phenotype	1.03430116
54	MP0003122_maternal_imprinting	1.03265993
55	MP0001919_abnormal_reproductive_system	1.03067925
56	MP0009046_muscle_twitch	1.01308679
57	MP0002557_abnormal_social/conspecific_i	0.98508623
58	MP0009764_decreased_sensitivity_to	0.96914654
59	MP0004742_abnormal_vestibular_system	0.96122180
60	MP0004924_abnormal_behavior	0.95404358
61	MP0005386_behavior/neurological_phenoty	0.95404358
62	MP0005187_abnormal_penis_morphology	0.94062495
63	MP0002572_abnormal_emotion/affect_behav	0.93507204
64	MP0001944_abnormal_pancreas_morphology	0.93485128
65	MP0002229_neurodegeneration	0.93055874
66	MP0003186_abnormal_redox_activity	0.92668815
67	MP0000371_diluted_coat_color	0.92580339
68	MP0002733_abnormal_thermal_nociception	0.91682711
69	MP0008872_abnormal_physiological_respon	0.91310539
70	MP0003633_abnormal_nervous_system	0.91174849
71	MP0003283_abnormal_digestive_organ	0.90819615
72	MP0003806_abnormal_nucleotide_metabolis	0.90665580
73	MP0002751_abnormal_autonomic_nervous	0.90475420
74	MP0004381_abnormal_hair_follicle	0.90134117
75	MP0000470_abnormal_stomach_morphology	0.89576710
76	MP0002938_white_spotting	0.88065390
77	MP0002909_abnormal_adrenal_gland	0.87954401
78	MP0002067_abnormal_sensory_capabilities	0.85204416
79	MP0001963_abnormal_hearing_physiology	0.84226131
80	MP0009765_abnormal_xenobiotic_induced	0.82930476
81	MP0002752_abnormal_somatic_nervous	0.82880622
82	MP0000383_abnormal_hair_follicle	0.81716932
83	MP0001970_abnormal_pain_threshold	0.80070078
84	MP0005423_abnormal_somatic_nervous	0.78082233
85	MP0001765_abnormal_ion_homeostasis	0.78022257
86	MP0001299_abnormal_eye_distance/	0.77626021
87	MP0001905_abnormal_dopamine_level	0.77213336
88	MP0009785_altered_susceptibility_to	0.77097971
89	MP0005367_renal/urinary_system_phenotyp	0.77093677
90	MP0000516_abnormal_urinary_system	0.77093677
91	MP0001293_anophthalmia	0.76612981
92	MP0010094_abnormal_chromosome_stability	0.76244206
93	MP0010386_abnormal_urinary_bladder	0.75276284
94	MP0008789_abnormal_olfactory_epithelium	0.74939313
95	MP0008775_abnormal_heart_ventricle	0.74684143
96	MP0000230_abnormal_systemic_arterial	0.71429303
97	MP0002148_abnormal_hypersensitivity_rea	0.71167984
98	MP0005647_abnormal_sex_gland	0.70992909
99	MP0003938_abnormal_ear_development	0.70982299
100	MP0001800_abnormal_humoral_immune	0.70965243

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the renal cortex (HP:0011035)	4.62787298
2	Pancreatic fibrosis (HP:0100732)	4.26295612
3	Pancreatic cysts (HP:0001737)	3.76047839
4	Nephronophthisis (HP:0000090)	3.63245137
5	Abnormality of the renal medulla (HP:0100957)	3.49005928
6	True hermaphroditism (HP:0010459)	3.44712488
7	Polydipsia (HP:0001959)	3.31479330
8	Abnormal drinking behavior (HP:0030082)	3.31479330
9	Molar tooth sign on MRI (HP:0002419)	3.23985739
10	Abnormality of midbrain morphology (HP:0002418)	3.23985739
11	Chronic hepatic failure (HP:0100626)	3.20205389
12	Renal cortical cysts (HP:0000803)	3.14874426
13	Hyperlipoproteinemia (HP:0010980)	3.12662320
14	Sclerocornea (HP:0000647)	2.98241262
15	Flat cornea (HP:0007720)	2.94380793
16	Oligodactyly (hands) (HP:0001180)	2.91850110
17	Intestinal atresia (HP:0011100)	2.91129399
18	Keratoconus (HP:0000563)	2.88445897
19	Increased corneal curvature (HP:0100692)	2.88445897
20	Fair hair (HP:0002286)	2.80777533
21	Prostate neoplasm (HP:0100787)	2.75059212
22	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.71915444
23	Medial flaring of the eyebrow (HP:0010747)	2.69383007
24	Chromsome breakage (HP:0040012)	2.68088211
25	Congenital hepatic fibrosis (HP:0002612)	2.67142307
26	Abnormality of chromosome stability (HP:0003220)	2.67100397
27	Anencephaly (HP:0002323)	2.57341047
28	Cystic liver disease (HP:0006706)	2.57048334
29	Action tremor (HP:0002345)	2.55629203
30	Gaze-evoked nystagmus (HP:0000640)	2.52960039
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.49759540
32	Tubular atrophy (HP:0000092)	2.48580566
33	Albinism (HP:0001022)	2.43608308
34	Occipital encephalocele (HP:0002085)	2.43363439
35	Meckel diverticulum (HP:0002245)	2.43171425
36	Polyuria (HP:0000103)	2.41288185
37	Generalized hypopigmentation of hair (HP:0011358)	2.41264274
38	Acute necrotizing encephalopathy (HP:0006965)	2.40878961
39	Tubulointerstitial fibrosis (HP:0005576)	2.39763625
40	Bony spicule pigmentary retinopathy (HP:0007737)	2.38210291
41	Abnormality of the ileum (HP:0001549)	2.37276058
42	Rhinitis (HP:0012384)	2.37193290
43	Congenital, generalized hypertrichosis (HP:0004540)	2.32811831
44	Hyperalaninemia (HP:0003348)	2.32745663
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32745663
46	Abnormality of alanine metabolism (HP:0010916)	2.32745663
47	Attenuation of retinal blood vessels (HP:0007843)	2.32223984
48	Supernumerary spleens (HP:0009799)	2.29855085
49	Clubbing of toes (HP:0100760)	2.29354300
50	Abnormal hair whorl (HP:0010721)	2.28924088
51	Progressive macrocephaly (HP:0004481)	2.25481794
52	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.25478729
53	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.25478729
54	Congenital stationary night blindness (HP:0007642)	2.22341365
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20247833
56	Cerebellar dysplasia (HP:0007033)	2.18481205
57	Constricted visual fields (HP:0001133)	2.17988358
58	Diastasis recti (HP:0001540)	2.15861407
59	Abnormality of the prostate (HP:0008775)	2.12709542
60	Decreased circulating renin level (HP:0003351)	2.11913546
61	Adrenal hypoplasia (HP:0000835)	2.09636137
62	Abnormality of DNA repair (HP:0003254)	2.06587121
63	Type II lissencephaly (HP:0007260)	2.05670835
64	Furrowed tongue (HP:0000221)	2.04936682
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.03155548
66	Febrile seizures (HP:0002373)	2.02207817
67	Astigmatism (HP:0000483)	2.01467243
68	Septo-optic dysplasia (HP:0100842)	2.00154934
69	Gait imbalance (HP:0002141)	1.98882065
70	Congenital primary aphakia (HP:0007707)	1.98058056
71	Short chin (HP:0000331)	1.97193933
72	Postaxial foot polydactyly (HP:0001830)	1.95636051
73	Severe visual impairment (HP:0001141)	1.95615811
74	Tubulointerstitial abnormality (HP:0001969)	1.95304594
75	Congenital sensorineural hearing impairment (HP:0008527)	1.93949122
76	Postural tremor (HP:0002174)	1.93358154
77	Widely spaced teeth (HP:0000687)	1.91350067
78	Acute encephalopathy (HP:0006846)	1.91053532
79	Abnormality of the preputium (HP:0100587)	1.89685586
80	Brushfield spots (HP:0001088)	1.88785059
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.88123943
82	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88123943
83	Asplenia (HP:0001746)	1.87927119
84	Abnormality of the carotid arteries (HP:0005344)	1.87635015
85	Abnormal ciliary motility (HP:0012262)	1.87527272
86	Atonic seizures (HP:0010819)	1.87413693
87	Abnormal urine output (HP:0012590)	1.86043333
88	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85887263
89	3-Methylglutaconic aciduria (HP:0003535)	1.84617569
90	Malnutrition (HP:0004395)	1.82892354
91	Abnormality of the aortic arch (HP:0012303)	1.82092506
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.80136380
93	Abnormality of the corticospinal tract (HP:0002492)	1.78979731
94	Volvulus (HP:0002580)	1.77951913
95	Male pseudohermaphroditism (HP:0000037)	1.77213897
96	Optic nerve hypoplasia (HP:0000609)	1.76104249
97	Postaxial hand polydactyly (HP:0001162)	1.75549186
98	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.74188538
99	Absent/shortened dynein arms (HP:0200106)	1.74188538
100	Flat occiput (HP:0005469)	1.74158841

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.63018579
2	TAOK3	4.14032422
3	ACVR1B	3.66853825
4	FRK	3.58576726
5	MAP4K2	3.48793904
6	PINK1	3.09185112
7	RIPK1	2.85087823
8	TLK1	2.80906603
9	CDK19	2.50946393
10	MKNK2	2.23508968
11	NTRK2	2.17590570
12	TGFBR1	2.00468024
13	OXSR1	1.96634693
14	MARK3	1.89594869
15	PIK3CG	1.74489027
16	WNK3	1.57660484
17	WNK4	1.56843921
18	CASK	1.56500040
19	CAMKK2	1.45687706
20	PNCK	1.43368231
21	PTK2B	1.34561180
22	NUAK1	1.32349242
23	ADRBK2	1.27205846
24	STK39	1.21494063
25	PLK2	1.19724900
26	ZAK	1.18041942
27	MAP3K12	1.16257892
28	TXK	1.14795198
29	MST4	1.03634502
30	NEK2	0.99631767
31	BTK	0.95216440
32	STK3	0.88746784
33	MKNK1	0.87248991
34	BLK	0.85485196
35	ITK	0.83691364
36	WNK1	0.81450325
37	ADRBK1	0.81004142
38	CCNB1	0.80928425
39	PHKG1	0.79231714
40	PHKG2	0.79231714
41	PAK3	0.78902319
42	ABL2	0.77702691
43	SIK2	0.75397158
44	EPHA4	0.74406776
45	BMPR2	0.74073860
46	GRK1	0.73404823
47	KIT	0.72948463
48	AKT3	0.71463938
49	MUSK	0.68936378
50	WEE1	0.68378947
51	GRK6	0.67142570
52	ERBB3	0.65365903
53	TRIM28	0.64487798
54	PIM1	0.62992605
55	STK11	0.62614058
56	DYRK3	0.62181221
57	KSR1	0.60909473
58	INSRR	0.60029274
59	CSF1R	0.59930597
60	MAPKAPK3	0.59335744
61	OBSCN	0.57826814
62	SGK1	0.56250843
63	MAP4K1	0.54582087
64	GRK5	0.54406943
65	TIE1	0.52023506
66	TNIK	0.51027630
67	ABL1	0.50909665
68	CAMK2A	0.50016721
69	CDK4	0.48821056
70	TEC	0.48571675
71	MYLK	0.47991223
72	PRKACA	0.46548119
73	PRKG1	0.46351727
74	IKBKB	0.46221663
75	ATR	0.44837340
76	CHUK	0.44355058
77	CDK8	0.44307529
78	ATM	0.43223507
79	GRK7	0.42709710
80	PKN1	0.41372995
81	CHEK2	0.41246847
82	IGF1R	0.41173006
83	MELK	0.40480166
84	BRD4	0.40343956
85	SGK2	0.39002376
86	NTRK3	0.37975315
87	DAPK2	0.37792447
88	LYN	0.37139179
89	MAPK13	0.35511489
90	SYK	0.35039640
91	PRKCH	0.34381275
92	PRKACB	0.34223686
93	PRKCQ	0.33041059
94	CSNK1G1	0.32755877
95	ERBB2	0.32635267
96	MAP3K4	0.31648634
97	PRKCI	0.31070756
98	RPS6KB2	0.30618996
99	PRKCE	0.30506544
100	CAMKK1	0.30369994

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.06929420
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.95900480
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.71971151
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.37643991
5	Homologous recombination_Homo sapiens_hsa03440	2.25824316
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.21452524
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.20126952
8	Parkinsons disease_Homo sapiens_hsa05012	2.15619923
9	Protein export_Homo sapiens_hsa03060	2.05188193
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96893529
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95077375
12	Allograft rejection_Homo sapiens_hsa05330	1.92554868
13	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.84372061
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.83446304
15	Olfactory transduction_Homo sapiens_hsa04740	1.83104854
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78851983
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.78679617
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.77586732
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.75783813
20	Phototransduction_Homo sapiens_hsa04744	1.71728240
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.68855467
22	Folate biosynthesis_Homo sapiens_hsa00790	1.65862398
23	Alzheimers disease_Homo sapiens_hsa05010	1.55432558
24	Caffeine metabolism_Homo sapiens_hsa00232	1.52260049
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50155274
26	Sphingolipid metabolism_Homo sapiens_hsa00600	1.48929993
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42658208
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.39507079
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.37323174
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33119671
31	Huntingtons disease_Homo sapiens_hsa05016	1.27814850
32	Morphine addiction_Homo sapiens_hsa05032	1.27212886
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21342257
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.18442188
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16681375
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09684752
37	RNA degradation_Homo sapiens_hsa03018	1.08579806
38	Peroxisome_Homo sapiens_hsa04146	1.08202409
39	Salivary secretion_Homo sapiens_hsa04970	1.07052577
40	Nicotine addiction_Homo sapiens_hsa05033	1.04198471
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01143634
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.99388099
43	Renin secretion_Homo sapiens_hsa04924	0.92699146
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91909866
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.89897930
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88680341
47	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88405374
48	Butanoate metabolism_Homo sapiens_hsa00650	0.84739943
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84658868
50	RNA polymerase_Homo sapiens_hsa03020	0.80777633
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.80334976
52	Insulin secretion_Homo sapiens_hsa04911	0.78963738
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.78318116
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76692902
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75666186
56	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.72333222
57	ABC transporters_Homo sapiens_hsa02010	0.70347428
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.69366715
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68970798
60	Mineral absorption_Homo sapiens_hsa04978	0.68018298
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67620704
62	Ribosome_Homo sapiens_hsa03010	0.66499323
63	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.65253541
64	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64972907
65	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.64881817
66	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.64482804
67	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61565706
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.60238536
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.58452123
70	Retinol metabolism_Homo sapiens_hsa00830	0.57357623
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57150456
72	Serotonergic synapse_Homo sapiens_hsa04726	0.56901762
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.54815150
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.53952710
75	Sulfur relay system_Homo sapiens_hsa04122	0.52620827
76	GABAergic synapse_Homo sapiens_hsa04727	0.49708525
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49575680
78	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.45532308
79	Purine metabolism_Homo sapiens_hsa00230	0.43372113
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42455630
81	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.41522049
82	Legionellosis_Homo sapiens_hsa05134	0.41216309
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39927691
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.39145425
85	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.38834536
86	Viral myocarditis_Homo sapiens_hsa05416	0.38409378
87	Basal transcription factors_Homo sapiens_hsa03022	0.38341487
88	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37013812
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.36934847
90	Chemokine signaling pathway_Homo sapiens_hsa04062	0.36874115
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.36160459
92	Cholinergic synapse_Homo sapiens_hsa04725	0.35045983
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34667286
94	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.34545022
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.34525131
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33770907
97	Metabolic pathways_Homo sapiens_hsa01100	0.33019270
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.32252679
99	Leishmaniasis_Homo sapiens_hsa05140	0.32102138
100	Circadian rhythm_Homo sapiens_hsa04710	0.30050764

FAM204BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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