ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	9.95014858
2	spermatid development (GO:0007286)	9.68227967
3	axonemal dynein complex assembly (GO:0070286)	9.62670302
4	reproduction (GO:0000003)	9.33892198
5	motile cilium assembly (GO:0044458)	9.25224264
6	cilium or flagellum-dependent cell motility (GO:0001539)	9.04237148
7	regulation of cilium movement (GO:0003352)	8.62634504
8	cilium movement (GO:0003341)	8.10161028
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.61712569
10	single fertilization (GO:0007338)	7.38188366
11	negative regulation of inclusion body assembly (GO:0090084)	7.27380954
12	sperm capacitation (GO:0048240)	7.20770774
13	synaptonemal complex organization (GO:0070193)	6.99593319
14	male meiosis (GO:0007140)	6.89663141
15	piRNA metabolic process (GO:0034587)	6.88101811
16	synaptonemal complex assembly (GO:0007130)	6.80481856
17	spermatogenesis (GO:0007283)	6.64460494
18	male gamete generation (GO:0048232)	6.62064406
19	microtubule depolymerization (GO:0007019)	6.44528338
20	organic cation transport (GO:0015695)	6.42344711
21	fertilization (GO:0009566)	6.21397452
22	gamete generation (GO:0007276)	6.08437621
23	regulation of inclusion body assembly (GO:0090083)	6.03206526
24	calcium ion-dependent exocytosis (GO:0017156)	6.02269234
25	germ cell development (GO:0007281)	5.37995542
26	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.30266167
27	ventricular system development (GO:0021591)	5.22069681
28	regulation of microtubule-based movement (GO:0060632)	5.13036347
29	glycerol ether metabolic process (GO:0006662)	5.10637569
30	cell recognition (GO:0008037)	5.07220070
31	spermatid nucleus differentiation (GO:0007289)	4.95807845
32	multicellular organismal reproductive process (GO:0048609)	4.79179837
33	chromosome condensation (GO:0030261)	4.75083302
34	ether metabolic process (GO:0018904)	4.72030759
35	male meiosis I (GO:0007141)	4.69559868
36	chromosome organization involved in meiosis (GO:0070192)	4.62902084
37	microtubule severing (GO:0051013)	4.61813201
38	DNA packaging (GO:0006323)	4.50520859
39	seminiferous tubule development (GO:0072520)	4.45940437
40	DNA methylation involved in gamete generation (GO:0043046)	4.40985073
41	sexual reproduction (GO:0019953)	4.22954457
42	left/right pattern formation (GO:0060972)	4.19583113
43	single strand break repair (GO:0000012)	4.11367791
44	meiotic nuclear division (GO:0007126)	4.02324745
45	chaperone-mediated protein complex assembly (GO:0051131)	3.89300657
46	multicellular organismal development (GO:0007275)	3.86711084
47	meiosis I (GO:0007127)	3.72231891
48	protein K11-linked deubiquitination (GO:0035871)	3.68785382
49	protein polyglutamylation (GO:0018095)	3.49634600
50	genitalia morphogenesis (GO:0035112)	3.42020176
51	protein localization to cilium (GO:0061512)	3.39135207
52	microtubule polymerization or depolymerization (GO:0031109)	3.38533708
53	glycolytic process (GO:0006096)	3.35642642
54	protein refolding (GO:0042026)	3.28142680
55	sequestering of actin monomers (GO:0042989)	3.27496495
56	monoubiquitinated protein deubiquitination (GO:0035520)	3.24947433
57	polyol catabolic process (GO:0046174)	3.23446983
58	carnitine transport (GO:0015879)	3.10240910
59	amino-acid betaine transport (GO:0015838)	3.10240910
60	meiotic cell cycle (GO:0051321)	3.07616486
61	regulation of spindle checkpoint (GO:0090231)	3.02703474
62	nucleoside diphosphate phosphorylation (GO:0006165)	3.02049858
63	alditol metabolic process (GO:0019400)	3.00004236
64	carnitine transmembrane transport (GO:1902603)	2.95330014
65	microtubule-based movement (GO:0007018)	2.90339098
66	nucleus organization (GO:0006997)	2.90042584
67	cilium organization (GO:0044782)	2.89561184
68	lactate metabolic process (GO:0006089)	2.87112361
69	mitotic sister chromatid cohesion (GO:0007064)	2.82579824
70	synapsis (GO:0007129)	2.82336446
71	cilium assembly (GO:0042384)	2.80526449
72	cellular component assembly involved in morphogenesis (GO:0010927)	2.75311711
73	axoneme assembly (GO:0035082)	2.73963209
74	RNA localization (GO:0006403)	2.73686815
75	GTP biosynthetic process (GO:0006183)	2.71537361
76	cilium morphogenesis (GO:0060271)	2.71406958
77	negative regulation of organelle assembly (GO:1902116)	2.70691343
78	intraciliary transport (GO:0042073)	2.69516995
79	meiotic cell cycle process (GO:1903046)	2.66060819
80	regulation of cilium assembly (GO:1902017)	2.65837384
81	interferon-gamma secretion (GO:0072643)	2.63040592
82	calcium ion import (GO:0070509)	2.61372278
83	polyamine biosynthetic process (GO:0006596)	2.56520495
84	positive regulation of macrophage activation (GO:0043032)	2.53735743
85	membrane depolarization during action potential (GO:0086010)	2.53628687
86	glycerol metabolic process (GO:0006071)	2.52721395
87	chromatin silencing (GO:0006342)	2.49705354
88	mitochondrion degradation (GO:0000422)	2.44679187
89	peptidyl-glutamic acid modification (GO:0018200)	2.40576989
90	sperm motility (GO:0030317)	14.1477057
91	fusion of sperm to egg plasma membrane (GO:0007342)	13.3215989
92	cell wall macromolecule catabolic process (GO:0016998)	12.4033306
93	cell wall macromolecule metabolic process (GO:0044036)	12.4033306
94	acrosome reaction (GO:0007340)	12.1415761
95	acrosome assembly (GO:0001675)	11.5092750
96	sperm-egg recognition (GO:0035036)	11.2177551
97	multicellular organism reproduction (GO:0032504)	10.7987441
98	plasma membrane fusion (GO:0045026)	10.3744263
99	binding of sperm to zona pellucida (GO:0007339)	10.2234164
100	cell-cell recognition (GO:0009988)	10.0906324

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	8.11364700
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.06133568
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.02958430
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.48475479
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.81114295
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.70144030
7	VDR_22108803_ChIP-Seq_LS180_Human	2.45822311
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.24324602
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11817446
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07522803
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.06210162
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98477260
13	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.94884205
14	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.89815992
15	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.89560637
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.85481445
17	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.78538920
18	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.74429536
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.72861086
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72197562
21	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.67428846
22	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.63398158
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57210742
24	STAT1_17558387_ChIP-Seq_HELA_Human	1.57064468
25	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52726631
26	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52608443
27	KDM2B_26808549_Chip-Seq_REH_Human	1.52229545
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50456522
29	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.47968559
30	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.46025118
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45848540
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.45848540
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.45002092
34	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.43355229
35	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.41837360
36	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33533541
37	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.32167483
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30482212
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30130197
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30130197
41	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.29789767
42	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25430891
43	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24530097
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24195098
45	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.21858384
46	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.20701713
47	P53_21459846_ChIP-Seq_SAOS-2_Human	1.20604417
48	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.20550264
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20494677
50	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.20048516
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19508307
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18602144
53	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.17251847
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17239075
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17165217
56	GF1_26923725_Chip-Seq_HPCs_Mouse	1.16718867
57	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.11442820
58	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.09660350
59	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.09538932
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08786619
61	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.07747511
62	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05988549
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05683542
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05221891
65	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.04211626
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04120399
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03879539
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02542042
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01612133
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01316638
71	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.01303710
72	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01247684
73	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.00607392
74	SOX9_26525672_Chip-Seq_HEART_Mouse	0.99079785
75	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.98790286
76	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.97789300
77	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.95983476
78	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.95656377
79	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94705061
80	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.94169542
81	P300_18555785_Chip-Seq_ESCs_Mouse	0.93794827
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93725060
83	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92715229
84	TBL1_22424771_ChIP-Seq_293T_Human	0.92263959
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92202694
86	ERG_20517297_ChIP-Seq_VCAP_Human	0.92103021
87	FUS_26573619_Chip-Seq_HEK293_Human	0.91960489
88	NFYB_21822215_ChIP-Seq_K562_Human	0.91347883
89	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.91239467
90	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.91157938
91	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.90241128
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.89263569
93	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.89155985
94	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.89145539
95	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.88907144
96	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.88576722
97	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.88024915
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.87833121
99	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.87485097
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.87358661

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	5.94943961
2	MP0001929_abnormal_gametogenesis	5.31590984
3	MP0008877_abnormal_DNA_methylation	4.09030218
4	MP0002161_abnormal_fertility/fecundity	3.23325836
5	MP0002210_abnormal_sex_determination	3.20249159
6	MP0005670_abnormal_white_adipose	2.81392605
7	MP0001145_abnormal_male_reproductive	2.68851075
8	MP0002653_abnormal_ependyma_morphology	2.33159127
9	MP0000653_abnormal_sex_gland	2.32923563
10	MP0005410_abnormal_fertilization	15.9087363
11	MP0002160_abnormal_reproductive_system	1.61742844
12	MP0003646_muscle_fatigue	1.55066854
13	MP0009046_muscle_twitch	1.49022749
14	MP0004233_abnormal_muscle_weight	1.38797826
15	MP0001984_abnormal_olfaction	1.34579015
16	MP0005623_abnormal_meninges_morphology	1.32845074
17	MP0004859_abnormal_synaptic_plasticity	1.22347535
18	MP0001765_abnormal_ion_homeostasis	1.18051553
19	MP0002282_abnormal_trachea_morphology	1.15606380
20	MP0002736_abnormal_nociception_after	1.13348544
21	MP0001968_abnormal_touch/_nociception	1.10188672
22	MP0005647_abnormal_sex_gland	1.06145622
23	MP0004270_analgesia	0.97324141
24	MP0003635_abnormal_synaptic_transmissio	0.89143715
25	MP0002234_abnormal_pharynx_morphology	0.85249585
26	MP0008995_early_reproductive_senescence	0.85061555
27	MP0003329_amyloid_beta_deposits	0.81016748
28	MP0003880_abnormal_central_pattern	0.80446048
29	MP0002063_abnormal_learning/memory/cond	0.76756001
30	MP0005389_reproductive_system_phenotype	0.75850600
31	MP0002572_abnormal_emotion/affect_behav	0.72240956
32	MP0000569_abnormal_digit_pigmentation	0.70592361
33	MP0003879_abnormal_hair_cell	0.67656855
34	MP0009745_abnormal_behavioral_response	0.65991949
35	MP0002735_abnormal_chemical_nociception	0.65453025
36	MP0003115_abnormal_respiratory_system	0.65313319
37	MP0002272_abnormal_nervous_system	0.64859036
38	MP0005551_abnormal_eye_electrophysiolog	0.63955770
39	MP0004036_abnormal_muscle_relaxation	0.61336110
40	MP0005377_hearing/vestibular/ear_phenot	0.59618807
41	MP0003878_abnormal_ear_physiology	0.59618807
42	MP0002064_seizures	0.59074831
43	MP0001440_abnormal_grooming_behavior	0.57213294
44	MP0004811_abnormal_neuron_physiology	0.56821601
45	MP0003633_abnormal_nervous_system	0.56582667
46	MP0008569_lethality_at_weaning	0.56541209
47	MP0008058_abnormal_DNA_repair	0.56428871
48	MP0005423_abnormal_somatic_nervous	0.55472967
49	MP0001486_abnormal_startle_reflex	0.55318695
50	MP0005636_abnormal_mineral_homeostasis	0.52247918
51	MP0000751_myopathy	0.51197589
52	MP0005666_abnormal_adipose_tissue	0.51161908
53	MP0002822_catalepsy	0.51044641
54	MP0002734_abnormal_mechanical_nocicepti	0.50061206
55	MP0003787_abnormal_imprinting	0.49400103
56	MP0005253_abnormal_eye_physiology	0.49374402
57	MP0002269_muscular_atrophy	0.49270907
58	MP0001324_abnormal_eye_pigmentation	0.48900257
59	MP0003011_delayed_dark_adaptation	0.47031064
60	MP0003631_nervous_system_phenotype	0.44391270
61	MP0001764_abnormal_homeostasis	0.44352950
62	MP0003699_abnormal_female_reproductive	0.44004579
63	MP0002067_abnormal_sensory_capabilities	0.43427341
64	MP0002909_abnormal_adrenal_gland	0.41585274
65	MP0002152_abnormal_brain_morphology	0.40687610
66	MP0009115_abnormal_fat_cell	0.39662254
67	MP0000534_abnormal_ureter_morphology	0.39425507
68	MP0002557_abnormal_social/conspecific_i	0.39272839
69	MP0004742_abnormal_vestibular_system	0.38660292
70	MP0005646_abnormal_pituitary_gland	0.38105749
71	MP0000358_abnormal_cell_content/	0.37576783
72	MP0004145_abnormal_muscle_electrophysio	0.36965073
73	MP0001502_abnormal_circadian_rhythm	0.36809596
74	MP0000604_amyloidosis	0.34526653
75	MP0002971_abnormal_brown_adipose	0.34168704
76	MP0002928_abnormal_bile_duct	0.32784661
77	MP0002882_abnormal_neuron_morphology	0.32284714
78	MP0000955_abnormal_spinal_cord	0.31451457
79	MP0002229_neurodegeneration	0.30879271
80	MP0002066_abnormal_motor_capabilities/c	0.29327197
81	MP0003861_abnormal_nervous_system	0.28335656
82	MP0006036_abnormal_mitochondrial_physio	0.26566933
83	MP0008961_abnormal_basal_metabolism	0.25943509
84	MP0002169_no_abnormal_phenotype	0.25720771
85	MP0002873_normal_phenotype	0.25654509
86	MP0003045_fibrosis	0.25625846
87	MP0002733_abnormal_thermal_nociception	0.25616271
88	MP0003950_abnormal_plasma_membrane	0.25092935
89	MP0005391_vision/eye_phenotype	0.25091597
90	MP0004133_heterotaxia	0.24323183
91	MP0001293_anophthalmia	0.22619745
92	MP0003942_abnormal_urinary_system	0.20848768
93	MP0003948_abnormal_gas_homeostasis	0.20830072
94	MP0002752_abnormal_somatic_nervous	0.20551746
95	MP0005535_abnormal_body_temperature	0.20265950
96	MP0003183_abnormal_peptide_metabolism	0.20123275
97	MP0004043_abnormal_pH_regulation	0.20101041
98	MP0001501_abnormal_sleep_pattern	0.19338811
99	MP0001119_abnormal_female_reproductive	0.19316768
100	MP0003632_abnormal_nervous_system	0.19306897

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	9.22093982
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.22093982
3	Abnormal respiratory motile cilium physiology (HP:0012261)	9.20960293
4	Abnormal ciliary motility (HP:0012262)	7.41340916
5	Rhinitis (HP:0012384)	7.21927857
6	Chronic bronchitis (HP:0004469)	7.10989058
7	Infertility (HP:0000789)	6.84849724
8	Nasal polyposis (HP:0100582)	5.96202285
9	Abnormality of the nasal mucosa (HP:0000433)	4.85869188
10	Male infertility (HP:0003251)	4.78589188
11	Bronchitis (HP:0012387)	4.30192653
12	Bronchiectasis (HP:0002110)	4.14584201
13	Nephronophthisis (HP:0000090)	4.11651588
14	Abnormal spermatogenesis (HP:0008669)	3.45636230
15	Recurrent sinusitis (HP:0011108)	3.22315529
16	Recurrent otitis media (HP:0000403)	3.11651475
17	Abnormality of the renal medulla (HP:0100957)	3.10678269
18	Tubulointerstitial nephritis (HP:0001970)	2.81305677
19	Medial flaring of the eyebrow (HP:0010747)	2.51232160
20	Abnormality of midbrain morphology (HP:0002418)	2.48817178
21	Molar tooth sign on MRI (HP:0002419)	2.48817178
22	Impulsivity (HP:0100710)	2.46298893
23	Tubular atrophy (HP:0000092)	2.43383189
24	Recurrent bronchitis (HP:0002837)	2.42995049
25	Cholecystitis (HP:0001082)	2.39276922
26	Abnormal gallbladder physiology (HP:0012438)	2.39276922
27	Tubulointerstitial abnormality (HP:0001969)	2.30595412
28	Gonadotropin excess (HP:0000837)	2.30223496
29	Dyschromatopsia (HP:0007641)	2.12305999
30	Azoospermia (HP:0000027)	2.10070312
31	Spastic tetraparesis (HP:0001285)	2.02982851
32	Decreased central vision (HP:0007663)	2.00066812
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.6738174
34	Absent/shortened dynein arms (HP:0200106)	13.6738174
35	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.6606142
36	Choroideremia (HP:0001139)	1.97228086
37	Postaxial foot polydactyly (HP:0001830)	1.77775384
38	Tubulointerstitial fibrosis (HP:0005576)	1.77491671
39	Stage 5 chronic kidney disease (HP:0003774)	1.73104630
40	Neurofibrillary tangles (HP:0002185)	1.71096130
41	Bundle branch block (HP:0011710)	1.69664231
42	Abnormality of the lower motor neuron (HP:0002366)	1.68966776
43	Polydipsia (HP:0001959)	1.66153996
44	Abnormal drinking behavior (HP:0030082)	1.66153996
45	Heterotopia (HP:0002282)	1.65471975
46	Congenital hepatic fibrosis (HP:0002612)	1.64917929
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.64460425
48	Asymmetric septal hypertrophy (HP:0001670)	1.62473561
49	Bile duct proliferation (HP:0001408)	1.61402837
50	Abnormal biliary tract physiology (HP:0012439)	1.61402837
51	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.55752554
52	Hemiparesis (HP:0001269)	1.55065668
53	Progressive cerebellar ataxia (HP:0002073)	1.54667109
54	Abnormality of renal excretion (HP:0011036)	1.54655669
55	Abnormality of the renal cortex (HP:0011035)	1.54544324
56	Aplasia/Hypoplasia of the lens (HP:0008063)	1.53116563
57	Oculomotor apraxia (HP:0000657)	1.51209250
58	Short ribs (HP:0000773)	1.51050785
59	Gait imbalance (HP:0002141)	1.50151328
60	Bell-shaped thorax (HP:0001591)	1.49703332
61	Abnormality of the dental root (HP:0006486)	1.49434430
62	Taurodontia (HP:0000679)	1.49434430
63	Abnormality of permanent molar morphology (HP:0011071)	1.49434430
64	Fibular hypoplasia (HP:0003038)	1.48826950
65	Postaxial hand polydactyly (HP:0001162)	1.47781433
66	Congenital primary aphakia (HP:0007707)	1.47205917
67	Hemorrhage of the eye (HP:0011885)	1.47012612
68	Exercise-induced myalgia (HP:0003738)	1.45061688
69	Cerebral inclusion bodies (HP:0100314)	1.42547770
70	Abnormality of ocular smooth pursuit (HP:0000617)	1.39354342
71	Abnormality of the dental pulp (HP:0006479)	1.38723279
72	Abnormality of dentin (HP:0010299)	1.38553947
73	Cystic liver disease (HP:0006706)	1.38328141
74	Abnormality of molar (HP:0011077)	1.37305606
75	Abnormality of molar morphology (HP:0011070)	1.37305606
76	Renal dysplasia (HP:0000110)	1.35941055
77	Double outlet right ventricle (HP:0001719)	1.31916104
78	Congenital malformation of the right heart (HP:0011723)	1.31916104
79	Amyotrophic lateral sclerosis (HP:0007354)	1.31875920
80	Pancreatic fibrosis (HP:0100732)	1.31311663
81	Deformed sella turcica (HP:0002681)	1.31304809
82	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.29174487
83	Absent epiphyses (HP:0010577)	1.29174487
84	Abnormal urine output (HP:0012590)	1.27921373
85	Gaze-evoked nystagmus (HP:0000640)	1.27856876
86	Sensory axonal neuropathy (HP:0003390)	1.26987500
87	Nephrogenic diabetes insipidus (HP:0009806)	1.26226579
88	Absent frontal sinuses (HP:0002688)	1.25147259
89	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.24675630
90	Abnormality of saccadic eye movements (HP:0000570)	1.24242195
91	Truncal obesity (HP:0001956)	1.23588896
92	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.23255135
93	Facial cleft (HP:0002006)	1.22600321
94	J-shaped sella turcica (HP:0002680)	1.22385039
95	Constricted visual fields (HP:0001133)	1.22087662
96	Chronic sinusitis (HP:0011109)	1.22081339
97	Broad distal phalanx of finger (HP:0009836)	1.20710630
98	Impaired smooth pursuit (HP:0007772)	1.19496947
99	Dysmetric saccades (HP:0000641)	1.19321277
100	True hermaphroditism (HP:0010459)	1.18704635

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	8.34025072
2	PDK3	8.34025072
3	TESK1	5.62407018
4	PDK2	5.35213015
5	PRKD3	5.22555572
6	ICK	4.24669456
7	PTK2B	2.23396878
8	PNCK	1.99411016
9	WNK4	1.99114722
10	STK39	1.86735253
11	STK38	1.83848677
12	DYRK1B	1.51975114
13	NEK2	1.27137038
14	PDK1	1.25676681
15	TYRO3	0.93307556
16	RIPK4	0.90715561
17	WNK1	0.79911302
18	PDPK1	0.77338775
19	EPHA4	0.76896094
20	DYRK3	0.72611253
21	PINK1	0.71062103
22	CCNB1	0.70802364
23	LMTK2	0.70295083
24	MAPK15	0.69070606
25	NTRK2	0.67879327
26	IRAK1	0.65777884
27	MAP2K6	0.63475770
28	NTRK3	0.62623812
29	CAMK1G	0.61083463
30	PRKCG	0.58738746
31	PASK	0.55397935
32	MAP3K4	0.54953036
33	CAMKK1	0.53644344
34	STK3	0.42817262
35	CHEK2	0.40788673
36	TTK	0.38422806
37	MAP2K7	0.38040000
38	MUSK	0.36375125
39	STK38L	0.33105687
40	PAK1	0.32762168
41	PAK6	0.32318961
42	EEF2K	0.31664664
43	MARK2	0.30147308
44	NEK6	0.29401070
45	CHEK1	0.29266558
46	TESK2	0.29082409
47	CDK15	0.27450408
48	MINK1	0.26805352
49	CDK18	0.25872202
50	MARK1	0.25415250
51	PRKCZ	0.25016735
52	IRAK2	0.23102974
53	CDK11A	0.21773769
54	CAMK2A	0.21046247
55	DAPK2	0.20260234
56	CDK14	0.19968498
57	RPS6KB1	0.19816164
58	ATM	0.19460950
59	PRKAA1	0.19047636
60	MAPKAPK5	0.17885088
61	MTOR	0.15769484
62	PAK2	0.15700238
63	STK11	0.15386396
64	PRKCQ	0.14424580
65	CDK5	0.13513959
66	MAP2K4	0.11100640
67	GSK3B	0.10557520
68	PRKG1	0.10044807
69	BRSK1	0.09991146
70	ATR	0.09563625
71	BRAF	0.09431364
72	CDK19	0.08872146
73	CAMK1	0.08269516
74	PRKACG	0.07711591
75	PRKCB	0.07243482
76	RPS6KA3	0.06856006
77	WNK3	0.06850622
78	CDK3	0.06376800
79	PAK4	0.06251777
80	PRKCA	0.06221085
81	MAPK8	0.05401084
82	MAP3K10	0.05320683
83	TAOK1	0.05199039
84	PRKG2	0.04546977
85	MARK3	0.04336155
86	CSNK1D	0.04155022
87	MAP3K1	0.04122629
88	OXSR1	0.03587643
89	PRKACA	0.02891369
90	DAPK1	0.02555173
91	PRKACB	0.02328131
92	MAP3K5	0.01825325
93	PRKCD	0.01781718
94	RPS6KA1	0.01171565
95	PHKG1	0.01096163
96	PHKG2	0.01096163
97	GRK5	0.00965688
98	PKN1	0.00761134
99	CDK1	0.00355009
100	TNIK	0.00329070

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.28033724
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.09228184
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.40199178
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.14416690
5	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.99569136
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.67167486
7	Glucagon signaling pathway_Homo sapiens_hsa04922	2.55496089
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.55421493
9	Propanoate metabolism_Homo sapiens_hsa00640	2.28413876
10	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.25530932
11	Amphetamine addiction_Homo sapiens_hsa05031	2.11297313
12	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.94987279
13	Glycerolipid metabolism_Homo sapiens_hsa00561	1.80816513
14	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.78327964
15	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.68313465
16	Basal transcription factors_Homo sapiens_hsa03022	1.66941306
17	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.65784323
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.63934961
19	Oocyte meiosis_Homo sapiens_hsa04114	1.62122525
20	PPAR signaling pathway_Homo sapiens_hsa03320	1.60460482
21	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.60035203
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.59683440
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.54780624
24	Collecting duct acid secretion_Homo sapiens_hsa04966	1.53339988
25	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.51384324
26	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.51109389
27	Long-term potentiation_Homo sapiens_hsa04720	1.46391894
28	Mineral absorption_Homo sapiens_hsa04978	1.45455715
29	Insulin secretion_Homo sapiens_hsa04911	1.45363962
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44411114
31	Renin secretion_Homo sapiens_hsa04924	1.43717511
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.33683868
33	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.31448924
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.23901792
35	Nicotine addiction_Homo sapiens_hsa05033	1.21053721
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.20701988
37	Circadian entrainment_Homo sapiens_hsa04713	1.17664463
38	Pentose phosphate pathway_Homo sapiens_hsa00030	1.16780412
39	Salivary secretion_Homo sapiens_hsa04970	1.15717068
40	Carbon metabolism_Homo sapiens_hsa01200	1.14947904
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.11517707
42	Fatty acid degradation_Homo sapiens_hsa00071	1.08653232
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.05935754
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.03698034
45	Gastric acid secretion_Homo sapiens_hsa04971	0.94799069
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.94664419
47	Estrogen signaling pathway_Homo sapiens_hsa04915	0.94644757
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.92028096
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.90949796
50	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.90305835
51	Taste transduction_Homo sapiens_hsa04742	0.89987148
52	Olfactory transduction_Homo sapiens_hsa04740	0.84159550
53	Bile secretion_Homo sapiens_hsa04976	0.83526997
54	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.83493475
55	Huntingtons disease_Homo sapiens_hsa05016	0.82987886
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80065725
57	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.79821416
58	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.77306454
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.76718073
60	Pancreatic secretion_Homo sapiens_hsa04972	0.76681991
61	Purine metabolism_Homo sapiens_hsa00230	0.74292019
62	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.73773888
63	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73303486
64	cAMP signaling pathway_Homo sapiens_hsa04024	0.72784933
65	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66914077
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.66310557
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.66052252
68	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.62344974
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62175492
70	Morphine addiction_Homo sapiens_hsa05032	0.60777567
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.60766246
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58538338
73	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.58518954
74	Cocaine addiction_Homo sapiens_hsa05030	0.57546218
75	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.55786136
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55764345
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54534193
78	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.53523535
79	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.52751542
80	Glutathione metabolism_Homo sapiens_hsa00480	0.47677700
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.47190966
82	Endocytosis_Homo sapiens_hsa04144	0.46643252
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.45276322
84	Protein digestion and absorption_Homo sapiens_hsa04974	0.44335090
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43943243
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.42563124
87	ABC transporters_Homo sapiens_hsa02010	0.39893617
88	VEGF signaling pathway_Homo sapiens_hsa04370	0.39198728
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36829320
90	AMPK signaling pathway_Homo sapiens_hsa04152	0.35717092
91	Renin-angiotensin system_Homo sapiens_hsa04614	0.31084112
92	RNA transport_Homo sapiens_hsa03013	0.30763334
93	Vibrio cholerae infection_Homo sapiens_hsa05110	0.27724358
94	GABAergic synapse_Homo sapiens_hsa04727	0.24937890
95	Metabolic pathways_Homo sapiens_hsa01100	0.24016071
96	Legionellosis_Homo sapiens_hsa05134	0.22629952
97	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.20202051
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.19353177
99	Alcoholism_Homo sapiens_hsa05034	0.18670085
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.16845161

FAM205C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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