FAM207BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.64472869
2ATP synthesis coupled proton transport (GO:0015986)6.64472869
3purine deoxyribonucleotide catabolic process (GO:0009155)6.60376602
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.54142271
5Arp2/3 complex-mediated actin nucleation (GO:0034314)6.02309915
6deoxyribonucleotide catabolic process (GO:0009264)5.37825349
7deoxyribose phosphate catabolic process (GO:0046386)5.16792668
8respiratory electron transport chain (GO:0022904)5.15471982
9ribosomal small subunit assembly (GO:0000028)5.12902799
10electron transport chain (GO:0022900)5.01739368
11actin nucleation (GO:0045010)4.99047275
12proteasome assembly (GO:0043248)4.85278220
13ribosomal small subunit biogenesis (GO:0042274)4.76546963
14DNA deamination (GO:0045006)4.67569544
15maturation of SSU-rRNA (GO:0030490)4.64085325
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61748430
17autophagic vacuole fusion (GO:0000046)4.38702583
18purine nucleotide salvage (GO:0032261)4.25662837
19viral transcription (GO:0019083)4.08131244
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.99620266
21NADH dehydrogenase complex assembly (GO:0010257)3.99620266
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99620266
23translational termination (GO:0006415)3.92962160
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.89917502
25purine deoxyribonucleotide metabolic process (GO:0009151)3.84287158
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.78707068
27sequestering of actin monomers (GO:0042989)3.69585869
28cotranslational protein targeting to membrane (GO:0006613)3.69120454
29ATP biosynthetic process (GO:0006754)3.62299824
30protein targeting to ER (GO:0045047)3.62041122
31hydrogen peroxide biosynthetic process (GO:0050665)3.60567344
32pyrimidine nucleotide catabolic process (GO:0006244)3.58642454
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.55456739
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47337234
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.46645923
36protein localization to endoplasmic reticulum (GO:0070972)3.45082324
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44581656
38protein complex biogenesis (GO:0070271)3.41169120
39reactive oxygen species biosynthetic process (GO:1903409)3.39803428
40purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.38325626
41regulation of RIG-I signaling pathway (GO:0039535)3.37981165
42translational elongation (GO:0006414)3.36055487
43hydrogen ion transmembrane transport (GO:1902600)3.32641576
44mitochondrial respiratory chain complex assembly (GO:0033108)3.32073870
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.25572662
46regulation of cellular amino acid metabolic process (GO:0006521)3.24262705
47deoxyribose phosphate metabolic process (GO:0019692)3.24234717
48positive regulation of lamellipodium assembly (GO:0010592)3.24047839
49antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.22730890
502-deoxyribonucleotide metabolic process (GO:0009394)3.20515344
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.20287682
52chaperone-mediated protein transport (GO:0072321)3.19845046
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19158762
54oxidative phosphorylation (GO:0006119)3.18838538
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18597987
56organelle membrane fusion (GO:0090174)3.16622454
57nucleoside diphosphate catabolic process (GO:0009134)3.15987945
58deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.15571322
59response to interferon-beta (GO:0035456)3.13742140
60energy homeostasis (GO:0097009)3.10523589
61positive regulation of growth hormone secretion (GO:0060124)3.10343251
62aerobic respiration (GO:0009060)3.08612384
63cytidine deamination (GO:0009972)3.03866061
64cytidine metabolic process (GO:0046087)3.03866061
65cytidine catabolic process (GO:0006216)3.03866061
66negative regulation of telomere maintenance (GO:0032205)3.02649599
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01738715
68secretory granule organization (GO:0033363)3.00247435
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98786786
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98786786
71pseudouridine synthesis (GO:0001522)2.97808246
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97443807
73cellular protein complex disassembly (GO:0043624)2.96860995
74translational initiation (GO:0006413)2.96105133
75viral life cycle (GO:0019058)2.95970307
76positive regulation of heart rate (GO:0010460)2.95693919
77proton transport (GO:0015992)2.95196247
78negative regulation of phagocytosis (GO:0050765)2.92852635
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92757284
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92757284
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92457682
82regulation of protein heterodimerization activity (GO:0043497)2.91888193
83deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.90619020
84platelet dense granule organization (GO:0060155)2.89878663
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89637727
86translation (GO:0006412)2.89476458
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89409527
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89409527
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89409527
90negative regulation of DNA biosynthetic process (GO:2000279)2.89202148
91ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89096198
92regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.88545785
93hydrogen transport (GO:0006818)2.88177087
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86873016
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86642994
96pyrimidine ribonucleoside catabolic process (GO:0046133)2.84323662
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83554982
98negative regulation of ligase activity (GO:0051352)2.82393239
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82393239
100deoxyribonucleotide metabolic process (GO:0009262)2.81966451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human5.26632223
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.67489141
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.12894544
4E2F7_22180533_ChIP-Seq_HELA_Human3.94062515
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92131781
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42294920
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.35397336
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27899253
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.27869912
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.20433789
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.93022929
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88192326
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.76226888
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47433260
15VDR_23849224_ChIP-Seq_CD4+_Human2.42378612
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41932782
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40525838
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38875141
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.30396887
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29793840
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.28888004
22FOXP3_21729870_ChIP-Seq_TREG_Human2.27029771
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17689532
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.16304792
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12817124
26ELK1_19687146_ChIP-ChIP_HELA_Human2.08810266
27DCP1A_22483619_ChIP-Seq_HELA_Human2.05071621
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97964619
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87378652
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85183187
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84692768
32ZNF263_19887448_ChIP-Seq_K562_Human1.84678359
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81721762
34GABP_19822575_ChIP-Seq_HepG2_Human1.74815281
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.73251364
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72460788
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69549121
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69477314
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68144535
40MYC_18940864_ChIP-ChIP_HL60_Human1.64733854
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60919551
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60456929
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58908837
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57264604
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56793427
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55032879
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49911719
48XRN2_22483619_ChIP-Seq_HELA_Human1.48998927
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47760729
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38330249
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37696591
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36350756
53TTF2_22483619_ChIP-Seq_HELA_Human1.36207878
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33978230
55SPI1_23547873_ChIP-Seq_NB4_Human1.29955032
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.22495689
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19811098
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19055444
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13843445
60FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13659250
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13569554
62CIITA_25753668_ChIP-Seq_RAJI_Human1.10035701
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09991388
64BCL6_27268052_Chip-Seq_Bcells_Human1.08741241
65MYB_26560356_Chip-Seq_TH2_Human1.08711603
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08530972
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08349808
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07049199
69VDR_21846776_ChIP-Seq_THP-1_Human1.04995893
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04961644
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04205027
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01758682
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01061426
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99809208
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98467415
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97721085
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94013773
78GATA3_26560356_Chip-Seq_TH2_Human0.93257009
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92523435
80CTCF_26484167_Chip-Seq_Bcells_Mouse0.91278456
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90194248
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90081729
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.90045882
84HTT_18923047_ChIP-ChIP_STHdh_Human0.88889328
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87714420
86GATA3_27048872_Chip-Seq_THYMUS_Human0.85317629
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84740943
88TAF2_19829295_ChIP-Seq_ESCs_Human0.84306630
89FOXP1_21924763_ChIP-Seq_HESCs_Human0.84277473
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83655132
91TP53_22573176_ChIP-Seq_HFKS_Human0.83404716
92SPI1_20517297_ChIP-Seq_HL60_Human0.83291453
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.81622428
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81490870
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81050961
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79652451
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.79388038
98ERG_20517297_ChIP-Seq_VCAP_Human0.77481350
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77240066
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75821140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.61532191
2MP0005671_abnormal_response_to3.51769648
3MP0005670_abnormal_white_adipose3.17583104
4MP0009785_altered_susceptibility_to2.99067112
5MP0008875_abnormal_xenobiotic_pharmacok2.69665107
6MP0000015_abnormal_ear_pigmentation2.54824421
7MP0003693_abnormal_embryo_hatching2.52436935
8MP0006036_abnormal_mitochondrial_physio2.41734719
9MP0008058_abnormal_DNA_repair2.33127367
10MP0003186_abnormal_redox_activity2.27859014
11MP0009764_decreased_sensitivity_to2.18146484
12MP0002095_abnormal_skin_pigmentation2.17081298
13MP0009697_abnormal_copulation2.05827112
14MP0001835_abnormal_antigen_presentation1.97895904
15MP0004145_abnormal_muscle_electrophysio1.94640215
16MP0009333_abnormal_splenocyte_physiolog1.91422507
17MP0006292_abnormal_olfactory_placode1.83653663
18MP0002090_abnormal_vision1.78645381
19MP0002102_abnormal_ear_morphology1.73788039
20MP0005025_abnormal_response_to1.73365867
21MP0003315_abnormal_perineum_morphology1.66732380
22MP0003724_increased_susceptibility_to1.63404697
23MP0005319_abnormal_enzyme/_coenzyme1.63319656
24MP0001764_abnormal_homeostasis1.62607461
25MP0003786_premature_aging1.61538467
26MP0002132_abnormal_respiratory_system1.60601010
27MP0010094_abnormal_chromosome_stability1.56663644
28MP0005464_abnormal_platelet_physiology1.54883344
29MP0006276_abnormal_autonomic_nervous1.49777551
30MP0005000_abnormal_immune_tolerance1.49736983
31MP0006072_abnormal_retinal_apoptosis1.44894049
32MP0002277_abnormal_respiratory_mucosa1.44786885
33MP0004957_abnormal_blastocyst_morpholog1.42715253
34MP0008872_abnormal_physiological_respon1.38109948
35MP0005330_cardiomyopathy1.36665362
36MP0002148_abnormal_hypersensitivity_rea1.34384698
37MP0001800_abnormal_humoral_immune1.33810606
38MP0002420_abnormal_adaptive_immunity1.33461614
39MP0003718_maternal_effect1.31855428
40MP0005332_abnormal_amino_acid1.30742477
41MP0002723_abnormal_immune_serum1.30460209
42MP0002405_respiratory_system_inflammati1.27301194
43MP0001819_abnormal_immune_cell1.26587491
44MP0003252_abnormal_bile_duct1.26390421
45MP0003075_altered_response_to1.24161496
46MP0005266_abnormal_metabolism1.23135129
47MP0000685_abnormal_immune_system1.20075590
48MP0003646_muscle_fatigue1.19579168
49MP0002452_abnormal_antigen_presenting1.19526317
50MP0002166_altered_tumor_susceptibility1.19417646
51MP0002736_abnormal_nociception_after1.18882060
52MP0008469_abnormal_protein_level1.18415056
53MP0005376_homeostasis/metabolism_phenot1.16394116
54MP0005646_abnormal_pituitary_gland1.15388656
55MP0003787_abnormal_imprinting1.14395524
56MP0008873_increased_physiological_sensi1.11815699
57MP0002876_abnormal_thyroid_physiology1.10556355
58MP0001881_abnormal_mammary_gland1.08414386
59MP0002419_abnormal_innate_immunity1.04812807
60MP0003567_abnormal_fetal_cardiomyocyte1.00279063
61MP0001502_abnormal_circadian_rhythm0.99850189
62MP0004043_abnormal_pH_regulation0.99821914
63MP0005253_abnormal_eye_physiology0.99331725
64MP0001845_abnormal_inflammatory_respons0.98052175
65MP0000716_abnormal_immune_system0.96104586
66MP0004019_abnormal_vitamin_homeostasis0.94852206
67MP0002019_abnormal_tumor_incidence0.92124284
68MP0003763_abnormal_thymus_physiology0.92111679
69MP0006082_CNS_inflammation0.91747106
70MP0008932_abnormal_embryonic_tissue0.90246580
71MP0002398_abnormal_bone_marrow0.90141292
72MP0003959_abnormal_lean_body0.89243717
73MP0001661_extended_life_span0.88962081
74MP0001905_abnormal_dopamine_level0.87616007
75MP0005636_abnormal_mineral_homeostasis0.87424140
76MP0003806_abnormal_nucleotide_metabolis0.86192341
77MP0000313_abnormal_cell_death0.85491014
78MP0001501_abnormal_sleep_pattern0.83775944
79MP0000689_abnormal_spleen_morphology0.83433373
80MP0001853_heart_inflammation0.80824074
81MP0002177_abnormal_outer_ear0.80796727
82MP0002429_abnormal_blood_cell0.80777877
83MP0003077_abnormal_cell_cycle0.80592883
84MP0001119_abnormal_female_reproductive0.79943477
85MP0009278_abnormal_bone_marrow0.79429523
86MP0002933_joint_inflammation0.78584485
87MP0005174_abnormal_tail_pigmentation0.77025032
88MP0002136_abnormal_kidney_physiology0.75891364
89MP0000230_abnormal_systemic_arterial0.74772211
90MP0001293_anophthalmia0.74193596
91MP0002722_abnormal_immune_system0.73870724
92MP0002006_tumorigenesis0.73832337
93MP0001756_abnormal_urination0.72593466
94MP0009763_increased_sensitivity_to0.71930528
95MP0001790_abnormal_immune_system0.71295012
96MP0005387_immune_system_phenotype0.71295012
97MP0000343_altered_response_to0.69766004
98MP0005075_abnormal_melanosome_morpholog0.69629655
99MP0001765_abnormal_ion_homeostasis0.65670473
100MP0006035_abnormal_mitochondrial_morpho0.65273213

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)5.33550267
2Increased hepatocellular lipid droplets (HP:0006565)5.17439128
3Increased intramyocellular lipid droplets (HP:0012240)4.73430979
4Mitochondrial inheritance (HP:0001427)4.72084167
5Increased muscle lipid content (HP:0009058)4.71726154
6Renal Fanconi syndrome (HP:0001994)4.56568224
7Acute necrotizing encephalopathy (HP:0006965)4.45101246
8Abnormal mitochondria in muscle tissue (HP:0008316)4.30913296
9Increased CSF lactate (HP:0002490)4.09889768
10Hepatocellular necrosis (HP:0001404)4.01680843
11Aplastic anemia (HP:0001915)3.94268712
12Elevated erythrocyte sedimentation rate (HP:0003565)3.91556602
13Hepatic necrosis (HP:0002605)3.76235573
14Sensory axonal neuropathy (HP:0003390)3.68087031
15Progressive macrocephaly (HP:0004481)3.61510944
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.57858268
17Exertional dyspnea (HP:0002875)3.50310966
18Acute encephalopathy (HP:0006846)3.40349318
19Reticulocytopenia (HP:0001896)3.32578454
203-Methylglutaconic aciduria (HP:0003535)3.28346905
21Respiratory difficulties (HP:0002880)3.18410894
22Obstructive lung disease (HP:0006536)3.12560416
23Chronic obstructive pulmonary disease (HP:0006510)3.12560416
24Cerebral edema (HP:0002181)3.10572672
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06662752
26Abnormality of the tricuspid valve (HP:0001702)3.00586292
27Abnormality of renal resorption (HP:0011038)2.98503153
28Increased serum lactate (HP:0002151)2.97787010
29Abnormality of B cell number (HP:0010975)2.94400533
30B lymphocytopenia (HP:0010976)2.90325925
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89002217
32Lactic acidosis (HP:0003128)2.86614305
33Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.73924292
34Thrombocytosis (HP:0001894)2.71370063
35Macrocytic anemia (HP:0001972)2.67332649
36Hyperphosphaturia (HP:0003109)2.62579148
37Abnormality of the phalanges of the 5th finger (HP:0004213)2.58012481
38Stenosis of the external auditory canal (HP:0000402)2.55595742
39Exercise intolerance (HP:0003546)2.54291662
40Generalized aminoaciduria (HP:0002909)2.53696158
41Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.49710914
42Abolished electroretinogram (ERG) (HP:0000550)2.49430195
43Abnormality of the prostate (HP:0008775)2.46695666
44Respiratory failure (HP:0002878)2.44725267
45Spastic paraparesis (HP:0002313)2.44147132
46Short middle phalanx of the 5th finger (HP:0004220)2.41100790
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40934290
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40934290
49Acute hepatic failure (HP:0006554)2.37946824
50Partial duplication of thumb phalanx (HP:0009944)2.37104935
51Glycosuria (HP:0003076)2.34369463
52Abnormality of urine glucose concentration (HP:0011016)2.34369463
53Autoimmune hemolytic anemia (HP:0001890)2.33332817
54Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.33164916
55Leukodystrophy (HP:0002415)2.30600634
5611 pairs of ribs (HP:0000878)2.30475750
57Hypoplasia of the radius (HP:0002984)2.27120559
58Symphalangism affecting the phalanges of the hand (HP:0009773)2.26395961
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.20523056
60Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.17650217
61Short 1st metacarpal (HP:0010034)2.17650217
62Birth length less than 3rd percentile (HP:0003561)2.17609438
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15937694
64Dicarboxylic aciduria (HP:0003215)2.15937694
65Pancytopenia (HP:0001876)2.13658012
66Mesangial abnormality (HP:0001966)2.08479032
67Partial duplication of the phalanx of hand (HP:0009999)2.07910655
68Hyperthyroidism (HP:0000836)2.07507334
69Pallor (HP:0000980)2.07443495
70Cellular immunodeficiency (HP:0005374)2.07124899
71Renal cortical cysts (HP:0000803)2.05978198
72Abnormality of cells of the erythroid lineage (HP:0012130)2.04457225
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03566539
74Hypoplastic left heart (HP:0004383)2.01108422
75Recurrent gram-negative bacterial infections (HP:0005420)1.97687905
76Symptomatic seizures (HP:0011145)1.96740081
77Constricted visual fields (HP:0001133)1.95568902
78Autoimmune thrombocytopenia (HP:0001973)1.95441705
79Severe combined immunodeficiency (HP:0004430)1.94888383
80Abnormality of the 1st metacarpal (HP:0010009)1.91860571
81Absent thumb (HP:0009777)1.91369789
82Spontaneous hematomas (HP:0007420)1.88368402
83Myotonia (HP:0002486)1.87830532
84Abnormal number of erythroid precursors (HP:0012131)1.87639203
85Synostosis of carpal bones (HP:0005048)1.87037865
86Oral leukoplakia (HP:0002745)1.86151487
87Abnormal urine phosphate concentration (HP:0012599)1.84830895
88Cleft eyelid (HP:0000625)1.83498695
89Congenital, generalized hypertrichosis (HP:0004540)1.81533883
90Testicular atrophy (HP:0000029)1.79629637
91Unilateral renal agenesis (HP:0000122)1.79273621
92Optic disc pallor (HP:0000543)1.79187998
93Prostate neoplasm (HP:0100787)1.78689464
94Recurrent abscess formation (HP:0002722)1.76875364
95Tetany (HP:0001281)1.76609224
96Abnormality of the distal phalanges of the toes (HP:0010182)1.74980375
97Colon cancer (HP:0003003)1.74239962
98Increased cerebral lipofuscin (HP:0011813)1.71815893
99Missing ribs (HP:0000921)1.69781766
100Aplasia/Hypoplasia of the thymus (HP:0010515)1.69411082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.98190650
2BCKDK4.27172665
3TESK24.08236403
4KDR3.69430875
5CDC73.34653134
6MAP3K123.03949193
7DAPK12.70316005
8NUAK12.63846980
9TESK12.61618835
10BMPR22.48780120
11NME22.37205285
12VRK22.32679999
13RPS6KA42.22015915
14CDK192.15447570
15MAPKAPK32.05381187
16LIMK12.03896475
17WNK41.96433043
18MYLK1.96023318
19TAOK31.94581443
20PBK1.40855135
21MAP3K61.37914413
22GRK61.32415374
23ILK1.15378307
24CSNK1G31.13370532
25MAP2K71.11193293
26OXSR11.00008918
27STK160.97549542
28VRK10.94012768
29AURKA0.88747764
30ATR0.86923522
31PDK20.86156938
32MAP4K20.83355836
33GRK10.83309782
34RPS6KA50.80110072
35TXK0.79119885
36STK390.78806398
37DAPK30.76142992
38CAMK10.75799343
39TRPM70.75537489
40ERN10.75474732
41CSNK1A1L0.72581931
42BMX0.71877337
43KIT0.68503792
44MAP4K10.67783784
45CLK10.67572471
46PAK10.66372123
47DMPK0.65742652
48CSNK1G10.65349816
49CSNK1G20.64895201
50PNCK0.64038726
51ADRBK20.60622058
52CAMKK20.60253363
53TBK10.60001110
54ABL20.59137109
55DYRK20.59079324
56CDK30.57565613
57FLT30.57071957
58RAF10.55452933
59MAPKAPK50.55367769
60CDK70.54993780
61ARAF0.54702048
62CAMK1G0.54254235
63CSNK2A10.53778368
64PIK3CA0.53063464
65IKBKE0.51698171
66MOS0.50897132
67ZAK0.50782379
68CSNK2A20.48517642
69MINK10.47797696
70SYK0.47268325
71CSF1R0.47143079
72TEC0.47111669
73EIF2AK30.46111501
74ITK0.45843358
75PLK10.45016608
76STK40.43265072
77INSRR0.41932211
78MKNK10.41488071
79CDK90.41056621
80CAMK2G0.41047204
81TAOK20.39456056
82MAP3K40.38818808
83LYN0.37780207
84IKBKB0.37360321
85MAP3K50.37174235
86GRK50.36875835
87MAPK130.35221948
88ROCK10.35157532
89CDK11A0.34561561
90MKNK20.32187886
91CDK80.31906853
92WNK30.31101834
93ZAP700.30959648
94PRKCQ0.30097333
95BUB10.29789678
96MAPKAPK20.29285501
97BTK0.28748841
98MAP3K110.28705565
99AURKB0.28561767
100CDK140.28489274

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.84227578
2Ribosome_Homo sapiens_hsa030104.21843321
3Proteasome_Homo sapiens_hsa030504.18982908
4Parkinsons disease_Homo sapiens_hsa050123.92178648
5Huntingtons disease_Homo sapiens_hsa050163.07935925
6Alzheimers disease_Homo sapiens_hsa050102.81374795
7DNA replication_Homo sapiens_hsa030302.69069405
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.60747224
9Homologous recombination_Homo sapiens_hsa034402.49132121
10Cardiac muscle contraction_Homo sapiens_hsa042602.14975668
11Asthma_Homo sapiens_hsa053102.04444556
12Protein export_Homo sapiens_hsa030601.98706027
13Mismatch repair_Homo sapiens_hsa034301.96271623
14Non-homologous end-joining_Homo sapiens_hsa034501.74052171
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71885789
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68901392
17Primary immunodeficiency_Homo sapiens_hsa053401.68535966
18Fanconi anemia pathway_Homo sapiens_hsa034601.63546854
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60235390
20Folate biosynthesis_Homo sapiens_hsa007901.53903815
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50972065
22Sulfur metabolism_Homo sapiens_hsa009201.48898249
23Spliceosome_Homo sapiens_hsa030401.48800985
24RNA polymerase_Homo sapiens_hsa030201.44883075
25Sulfur relay system_Homo sapiens_hsa041221.39598988
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.37894911
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.34553143
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29402289
29RNA degradation_Homo sapiens_hsa030181.26818046
30Pyrimidine metabolism_Homo sapiens_hsa002401.25421842
31Base excision repair_Homo sapiens_hsa034101.22985654
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19812910
33Graft-versus-host disease_Homo sapiens_hsa053321.19535838
34Nucleotide excision repair_Homo sapiens_hsa034201.17033643
35Allograft rejection_Homo sapiens_hsa053301.11059682
36Autoimmune thyroid disease_Homo sapiens_hsa053201.10521101
37Glutathione metabolism_Homo sapiens_hsa004801.09159883
38One carbon pool by folate_Homo sapiens_hsa006701.02681392
39Rheumatoid arthritis_Homo sapiens_hsa053231.00638018
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00487988
41Antigen processing and presentation_Homo sapiens_hsa046121.00484209
42Propanoate metabolism_Homo sapiens_hsa006400.93036403
43Pyruvate metabolism_Homo sapiens_hsa006200.91656624
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89559060
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88166530
46Type I diabetes mellitus_Homo sapiens_hsa049400.84100161
47Chemical carcinogenesis_Homo sapiens_hsa052040.81981413
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81157519
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81150405
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80043405
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78771723
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.77799503
53Salmonella infection_Homo sapiens_hsa051320.73508753
54RNA transport_Homo sapiens_hsa030130.73219744
55Tryptophan metabolism_Homo sapiens_hsa003800.72746430
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72516036
57beta-Alanine metabolism_Homo sapiens_hsa004100.71971121
58Purine metabolism_Homo sapiens_hsa002300.71962928
59Metabolic pathways_Homo sapiens_hsa011000.70669897
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70485656
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67095741
62Peroxisome_Homo sapiens_hsa041460.66270862
63Tyrosine metabolism_Homo sapiens_hsa003500.65995412
64Viral myocarditis_Homo sapiens_hsa054160.63675476
65Fatty acid degradation_Homo sapiens_hsa000710.63331940
66Basal transcription factors_Homo sapiens_hsa030220.63210569
67Systemic lupus erythematosus_Homo sapiens_hsa053220.62671142
68Regulation of autophagy_Homo sapiens_hsa041400.60291728
69Pertussis_Homo sapiens_hsa051330.57968723
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55735448
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52389907
72Collecting duct acid secretion_Homo sapiens_hsa049660.49110575
73Ether lipid metabolism_Homo sapiens_hsa005650.48759723
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47877146
75Hematopoietic cell lineage_Homo sapiens_hsa046400.46419186
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44869490
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44810087
78Fatty acid elongation_Homo sapiens_hsa000620.42550380
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41414757
80Renin-angiotensin system_Homo sapiens_hsa046140.40813129
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38731684
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38693132
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37011186
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.35881293
85Shigellosis_Homo sapiens_hsa051310.34318348
86p53 signaling pathway_Homo sapiens_hsa041150.34087721
87Steroid biosynthesis_Homo sapiens_hsa001000.33388725
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32687810
89Linoleic acid metabolism_Homo sapiens_hsa005910.32635243
90Retinol metabolism_Homo sapiens_hsa008300.32271126
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31840675
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30601661
93Selenocompound metabolism_Homo sapiens_hsa004500.29248198
94Leishmaniasis_Homo sapiens_hsa051400.26579212
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.26404493
96Carbon metabolism_Homo sapiens_hsa012000.23402574
97Herpes simplex infection_Homo sapiens_hsa051680.21525237
98Caffeine metabolism_Homo sapiens_hsa002320.20940643
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20392823
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.20238697

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