

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 6.62455701 |
| 2 | nuclear pore organization (GO:0006999) | 6.01892198 |
| 3 | mitotic sister chromatid cohesion (GO:0007064) | 5.32641437 |
| 4 | pore complex assembly (GO:0046931) | 5.04448895 |
| 5 | regulation of RNA export from nucleus (GO:0046831) | 4.88675250 |
| 6 | pre-miRNA processing (GO:0031054) | 4.61911778 |
| 7 | meiotic chromosome segregation (GO:0045132) | 4.16332995 |
| 8 | monoubiquitinated protein deubiquitination (GO:0035520) | 4.02704176 |
| 9 | mitotic chromosome condensation (GO:0007076) | 3.92686151 |
| 10 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.90811706 |
| 11 | synaptonemal complex assembly (GO:0007130) | 3.89115286 |
| 12 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.81060290 |
| 13 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.81060290 |
| 14 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.81060290 |
| 15 | piRNA metabolic process (GO:0034587) | 3.78932607 |
| 16 | mitotic nuclear envelope disassembly (GO:0007077) | 3.72460336 |
| 17 | dosage compensation (GO:0007549) | 3.69028115 |
| 18 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.66437452 |
| 19 | gene silencing by RNA (GO:0031047) | 3.60841643 |
| 20 | nuclear envelope disassembly (GO:0051081) | 3.53817791 |
| 21 | membrane disassembly (GO:0030397) | 3.53817791 |
| 22 | regulation of histone H3-K9 methylation (GO:0051570) | 3.53724289 |
| 23 | sister chromatid cohesion (GO:0007062) | 3.51585218 |
| 24 | synaptonemal complex organization (GO:0070193) | 3.51144727 |
| 25 | regulation of sister chromatid cohesion (GO:0007063) | 3.50207949 |
| 26 | ribosome assembly (GO:0042255) | 3.49202690 |
| 27 | kinetochore organization (GO:0051383) | 3.48266848 |
| 28 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.45935132 |
| 29 | negative regulation of histone methylation (GO:0031061) | 3.44613403 |
| 30 | heterochromatin organization (GO:0070828) | 3.42188729 |
| 31 | male meiosis (GO:0007140) | 3.32671483 |
| 32 | NLS-bearing protein import into nucleus (GO:0006607) | 3.29835278 |
| 33 | regulation of protein polyubiquitination (GO:1902914) | 3.27715089 |
| 34 | histone H3-K36 demethylation (GO:0070544) | 3.25280231 |
| 35 | negative regulation of DNA repair (GO:0045738) | 3.24398451 |
| 36 | histone H3-K9 demethylation (GO:0033169) | 3.22647073 |
| 37 | regulation of meiosis I (GO:0060631) | 3.22440054 |
| 38 | histone mRNA catabolic process (GO:0071044) | 3.21235220 |
| 39 | positive regulation of chromosome segregation (GO:0051984) | 3.17563973 |
| 40 | positive regulation of transcription from RNA polymerase III promoter (GO:0045945) | 3.15154946 |
| 41 | DNA synthesis involved in DNA repair (GO:0000731) | 3.15150938 |
| 42 | sister chromatid segregation (GO:0000819) | 3.14091238 |
| 43 | regulation of centrosome duplication (GO:0010824) | 3.11375368 |
| 44 | chromatin assembly (GO:0031497) | 3.10653203 |
| 45 | DNA replication initiation (GO:0006270) | 3.08356198 |
| 46 | histone H2A monoubiquitination (GO:0035518) | 3.07905297 |
| 47 | resolution of meiotic recombination intermediates (GO:0000712) | 3.07852793 |
| 48 | regulation of centriole replication (GO:0046599) | 3.07608587 |
| 49 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.07310502 |
| 50 | non-recombinational repair (GO:0000726) | 3.07310502 |
| 51 | regulation of histone H3-K27 methylation (GO:0061085) | 3.06635597 |
| 52 | cellular protein complex localization (GO:0034629) | 3.06288407 |
| 53 | gene silencing (GO:0016458) | 3.05938370 |
| 54 | protein localization to kinetochore (GO:0034501) | 3.03653920 |
| 55 | mRNA transport (GO:0051028) | 3.03475605 |
| 56 | nucleus organization (GO:0006997) | 3.03057262 |
| 57 | embryonic process involved in female pregnancy (GO:0060136) | 3.01069849 |
| 58 | DNA duplex unwinding (GO:0032508) | 3.00947378 |
| 59 | DNA geometric change (GO:0032392) | 2.99104208 |
| 60 | establishment of chromosome localization (GO:0051303) | 2.96340769 |
| 61 | Golgi transport vesicle coating (GO:0048200) | 2.93856069 |
| 62 | COPI coating of Golgi vesicle (GO:0048205) | 2.93856069 |
| 63 | chromosome organization involved in meiosis (GO:0070192) | 2.91287421 |
| 64 | protein export from nucleus (GO:0006611) | 2.91210976 |
| 65 | regulation of DNA endoreduplication (GO:0032875) | 2.90939695 |
| 66 | histone lysine demethylation (GO:0070076) | 2.88795443 |
| 67 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.88142141 |
| 68 | nuclear envelope organization (GO:0006998) | 2.87698555 |
| 69 | DNA packaging (GO:0006323) | 2.85404870 |
| 70 | mitotic metaphase plate congression (GO:0007080) | 2.84921514 |
| 71 | paraxial mesoderm development (GO:0048339) | 2.84153092 |
| 72 | kinetochore assembly (GO:0051382) | 2.83947065 |
| 73 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.83170622 |
| 74 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.81255011 |
| 75 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.80892188 |
| 76 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.80892188 |
| 77 | positive regulation of cell cycle checkpoint (GO:1901978) | 2.80654731 |
| 78 | histone demethylation (GO:0016577) | 2.79603854 |
| 79 | COPII vesicle coating (GO:0048208) | 2.79551448 |
| 80 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.78224077 |
| 81 | DNA strand elongation (GO:0022616) | 2.78130884 |
| 82 | regulation of spindle organization (GO:0090224) | 2.77858379 |
| 83 | chromosome condensation (GO:0030261) | 2.77803389 |
| 84 | mRNA stabilization (GO:0048255) | 2.76659898 |
| 85 | RNA stabilization (GO:0043489) | 2.76659898 |
| 86 | mRNA export from nucleus (GO:0006406) | 2.76366632 |
| 87 | DNA conformation change (GO:0071103) | 2.76197267 |
| 88 | protein localization to chromosome, centromeric region (GO:0071459) | 2.76133036 |
| 89 | regulation of chromosome segregation (GO:0051983) | 2.75864189 |
| 90 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.75286875 |
| 91 | protein complex localization (GO:0031503) | 2.75264210 |
| 92 | metaphase plate congression (GO:0051310) | 2.75148585 |
| 93 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.75034141 |
| 94 | mitotic sister chromatid segregation (GO:0000070) | 2.74406007 |
| 95 | meiotic nuclear division (GO:0007126) | 2.74069529 |
| 96 | protein localization to chromosome (GO:0034502) | 2.72656360 |
| 97 | histone H3-K9 methylation (GO:0051567) | 2.72519892 |
| 98 | nucleic acid transport (GO:0050657) | 2.72446647 |
| 99 | RNA transport (GO:0050658) | 2.72446647 |
| 100 | establishment of RNA localization (GO:0051236) | 2.72446647 |
| 101 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.72430684 |
| 102 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.72053939 |
| 103 | regulation of double-strand break repair (GO:2000779) | 2.71229915 |
| 104 | replication fork processing (GO:0031297) | 2.70877989 |
| 105 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.69750285 |
| 106 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.69583265 |
| 107 | regulation of centrosome cycle (GO:0046605) | 2.68808703 |
| 108 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.67844718 |
| 109 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.67844718 |
| 110 | regulation of sister chromatid segregation (GO:0033045) | 2.67844718 |
| 111 | negative regulation of chromosome segregation (GO:0051985) | 2.67522149 |
| 112 | chromatin assembly or disassembly (GO:0006333) | 2.67394659 |
| 113 | hemidesmosome assembly (GO:0031581) | 2.67392328 |
| 114 | DNA methylation involved in gamete generation (GO:0043046) | 2.65488086 |
| 115 | RNA export from nucleus (GO:0006405) | 2.65484577 |
| 116 | peptidyl-lysine dimethylation (GO:0018027) | 2.65427102 |
| 117 | regulation of translational fidelity (GO:0006450) | 2.64454446 |
| 118 | DNA topological change (GO:0006265) | 2.63997665 |
| 119 | genitalia morphogenesis (GO:0035112) | 2.63819851 |
| 120 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.61445567 |
| 121 | regulation of mitotic spindle organization (GO:0060236) | 2.61430508 |
| 122 | DNA unwinding involved in DNA replication (GO:0006268) | 2.61058792 |
| 123 | DNA methylation (GO:0006306) | 2.61029869 |
| 124 | DNA alkylation (GO:0006305) | 2.61029869 |
| 125 | positive regulation of DNA-templated transcription, initiation (GO:2000144) | 2.60095714 |
| 126 | hippo signaling (GO:0035329) | 2.59608230 |
| 127 | regulation of DNA damage checkpoint (GO:2000001) | 2.57301005 |
| 128 | activation of Rac GTPase activity (GO:0032863) | 2.56424980 |
| 129 | histone phosphorylation (GO:0016572) | 2.55790398 |
| 130 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.53918019 |
| 131 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) | 2.53728740 |
| 132 | N-terminal protein amino acid acetylation (GO:0006474) | 2.53626564 |
| 133 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.52127432 |
| 134 | DNA replication checkpoint (GO:0000076) | 2.50265994 |
| 135 | regulation of histone methylation (GO:0031060) | 2.48338260 |
| 136 | focal adhesion assembly (GO:0048041) | 2.48067816 |
| 137 | cell-substrate adherens junction assembly (GO:0007045) | 2.48067816 |
| 138 | spindle organization (GO:0007051) | 2.45377722 |
| 139 | chromosome segregation (GO:0007059) | 2.44692686 |
| 140 | histone-serine phosphorylation (GO:0035404) | 2.44091137 |
| 141 | mitotic cytokinesis (GO:0000281) | 2.43817431 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.95658723 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.09965865 |
| 3 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 4.42940499 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.81290464 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.76415189 |
| 6 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.62879842 |
| 7 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 3.39577228 |
| 8 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.22618998 |
| 9 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.87147651 |
| 10 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.80865738 |
| 11 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.52110883 |
| 12 | MYC_22102868_ChIP-Seq_BL_Human | 2.51708358 |
| 13 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.49274906 |
| 14 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.46851338 |
| 15 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.27961995 |
| 16 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.11799143 |
| 17 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.01850893 |
| 18 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.00600960 |
| 19 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.98898683 |
| 20 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.90905450 |
| 21 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.87268994 |
| 22 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.87191634 |
| 23 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.87041582 |
| 24 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.79946113 |
| 25 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.78416749 |
| 26 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.75283326 |
| 27 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.61770375 |
| 28 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.57726690 |
| 29 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.57222318 |
| 30 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.55461914 |
| 31 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.55380902 |
| 32 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.52394614 |
| 33 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.52394614 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.51170529 |
| 35 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.48700526 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47265498 |
| 37 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.46952507 |
| 38 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.44558003 |
| 39 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.44120318 |
| 40 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.43818393 |
| 41 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.41526613 |
| 42 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.38246400 |
| 43 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.37999221 |
| 44 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.36490809 |
| 45 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.36204010 |
| 46 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.32818686 |
| 47 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.32246050 |
| 48 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.30151723 |
| 49 | MYB_26560356_Chip-Seq_TH1_Human | 1.27544064 |
| 50 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.26207307 |
| 51 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.24978651 |
| 52 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.23497848 |
| 53 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.22420656 |
| 54 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.21668835 |
| 55 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.20265840 |
| 56 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.18869792 |
| 57 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.18849788 |
| 58 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.16618220 |
| 59 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.15981633 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.15854962 |
| 61 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.15664545 |
| 62 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.15057296 |
| 63 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.14483843 |
| 64 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.14013610 |
| 65 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.12719231 |
| 66 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.11911905 |
| 67 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.11155148 |
| 68 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.10825634 |
| 69 | MYB_26560356_Chip-Seq_TH2_Human | 1.10525718 |
| 70 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.10318464 |
| 71 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.08779135 |
| 72 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.08620301 |
| 73 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.08321914 |
| 74 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.07612977 |
| 75 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.06759229 |
| 76 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.06632905 |
| 77 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.05904100 |
| 78 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.04965980 |
| 79 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.04526702 |
| 80 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.04297701 |
| 81 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.02412292 |
| 82 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.01935372 |
| 83 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.01630745 |
| 84 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.01544131 |
| 85 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.01417123 |
| 86 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.99414316 |
| 87 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.98914104 |
| 88 | GATA1_22025678_ChIP-Seq_K562_Human | 0.98092648 |
| 89 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.96451806 |
| 90 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.95782318 |
| 91 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.95391512 |
| 92 | UTX_26944678_Chip-Seq_JUKART_Human | 0.94897874 |
| 93 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.94873473 |
| 94 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.94174448 |
| 95 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.93294459 |
| 96 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.92926447 |
| 97 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.91829438 |
| 98 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.91466479 |
| 99 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.91062737 |
| 100 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.91062737 |
| 101 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.91062737 |
| 102 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.90264276 |
| 103 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.90015153 |
| 104 | ATF3_27146783_Chip-Seq_COLON_Human | 0.89846805 |
| 105 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.89762977 |
| 106 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.88610903 |
| 107 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.88489160 |
| 108 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.87700008 |
| 109 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.87683318 |
| 110 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.86900861 |
| 111 | MAF_26560356_Chip-Seq_TH1_Human | 0.85977221 |
| 112 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85857928 |
| 113 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.82378407 |
| 114 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.82321832 |
| 115 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.81867053 |
| 116 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.81468136 |
| 117 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.80297536 |
| 118 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.79933463 |
| 119 | FUS_26573619_Chip-Seq_HEK293_Human | 0.79829064 |
| 120 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.79789881 |
| 121 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.79677257 |
| 122 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.78417068 |
| 123 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.77738051 |
| 124 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.77169976 |
| 125 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.77009160 |
| 126 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.76900632 |
| 127 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.75666694 |
| 128 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.75141667 |
| 129 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.74568042 |
| 130 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.74236698 |
| 131 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.74155253 |
| 132 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.73460856 |
| 133 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.73398976 |
| 134 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.71444360 |
| 135 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.69704677 |
| 136 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.69162669 |
| 137 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.68496957 |
| 138 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.67204001 |
| 139 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.67146773 |
| 140 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.67024772 |
| 141 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.66952971 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 4.39839497 |
| 2 | MP0008877_abnormal_DNA_methylation | 3.72999709 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.13664374 |
| 4 | MP0010352_gastrointestinal_tract_polyps | 2.97751509 |
| 5 | MP0003111_abnormal_nucleus_morphology | 2.62843312 |
| 6 | MP0000569_abnormal_digit_pigmentation | 2.61203046 |
| 7 | MP0005076_abnormal_cell_differentiation | 2.58832052 |
| 8 | MP0003077_abnormal_cell_cycle | 2.52187961 |
| 9 | MP0003890_abnormal_embryonic-extraembry | 2.39731323 |
| 10 | MP0010307_abnormal_tumor_latency | 2.38757286 |
| 11 | MP0008058_abnormal_DNA_repair | 2.35727859 |
| 12 | MP0003693_abnormal_embryo_hatching | 2.30105957 |
| 13 | MP0004957_abnormal_blastocyst_morpholog | 2.22449854 |
| 14 | MP0003123_paternal_imprinting | 2.01798631 |
| 15 | MP0008007_abnormal_cellular_replicative | 1.98583298 |
| 16 | MP0003121_genomic_imprinting | 1.94674553 |
| 17 | MP0001730_embryonic_growth_arrest | 1.85910530 |
| 18 | MP0004197_abnormal_fetal_growth/weight/ | 1.83578601 |
| 19 | MP0002396_abnormal_hematopoietic_system | 1.79290971 |
| 20 | MP0009278_abnormal_bone_marrow | 1.77875524 |
| 21 | MP0009697_abnormal_copulation | 1.77607308 |
| 22 | MP0000350_abnormal_cell_proliferation | 1.77537137 |
| 23 | MP0010678_abnormal_skin_adnexa | 1.76576781 |
| 24 | MP0003787_abnormal_imprinting | 1.75884806 |
| 25 | MP0002084_abnormal_developmental_patter | 1.75270526 |
| 26 | MP0004808_abnormal_hematopoietic_stem | 1.74351384 |
| 27 | MP0003941_abnormal_skin_development | 1.72961074 |
| 28 | MP0005380_embryogenesis_phenotype | 1.72305010 |
| 29 | MP0001672_abnormal_embryogenesis/_devel | 1.72305010 |
| 30 | MP0004185_abnormal_adipocyte_glucose | 1.67906945 |
| 31 | MP0002210_abnormal_sex_determination | 1.67230946 |
| 32 | MP0002086_abnormal_extraembryonic_tissu | 1.67163057 |
| 33 | MP0001929_abnormal_gametogenesis | 1.65950247 |
| 34 | MP0003950_abnormal_plasma_membrane | 1.65812886 |
| 35 | MP0003705_abnormal_hypodermis_morpholog | 1.65180657 |
| 36 | MP0002009_preneoplasia | 1.64954541 |
| 37 | MP0001661_extended_life_span | 1.64493551 |
| 38 | MP0003984_embryonic_growth_retardation | 1.63812281 |
| 39 | MP0002088_abnormal_embryonic_growth/wei | 1.60451832 |
| 40 | MP0001697_abnormal_embryo_size | 1.59892872 |
| 41 | MP0010030_abnormal_orbit_morphology | 1.59337677 |
| 42 | MP0001293_anophthalmia | 1.53596109 |
| 43 | MP0003786_premature_aging | 1.53324783 |
| 44 | MP0002085_abnormal_embryonic_tissue | 1.52796947 |
| 45 | MP0008995_early_reproductive_senescence | 1.49750666 |
| 46 | MP0001145_abnormal_male_reproductive | 1.41957146 |
| 47 | MP0000383_abnormal_hair_follicle | 1.36210968 |
| 48 | MP0002166_altered_tumor_susceptibility | 1.35156314 |
| 49 | MP0005409_darkened_coat_color | 1.30395509 |
| 50 | MP0004272_abnormal_basement_membrane | 1.29460139 |
| 51 | MP0005451_abnormal_body_composition | 1.28167072 |
| 52 | MP0003763_abnormal_thymus_physiology | 1.27616784 |
| 53 | MP0003300_gastrointestinal_ulcer | 1.27519586 |
| 54 | MP0000653_abnormal_sex_gland | 1.26757512 |
| 55 | MP0009053_abnormal_anal_canal | 1.24754924 |
| 56 | MP0003119_abnormal_digestive_system | 1.24039120 |
| 57 | MP0009703_decreased_birth_body | 1.21491005 |
| 58 | MP0005410_abnormal_fertilization | 1.21461603 |
| 59 | MP0008438_abnormal_cutaneous_collagen | 1.20882800 |
| 60 | MP0003935_abnormal_craniofacial_develop | 1.20055907 |
| 61 | MP0004264_abnormal_extraembryonic_tissu | 1.19630779 |
| 62 | MP0002080_prenatal_lethality | 1.18424457 |
| 63 | MP0003698_abnormal_male_reproductive | 1.18242967 |
| 64 | MP0003718_maternal_effect | 1.17751104 |
| 65 | MP0002877_abnormal_melanocyte_morpholog | 1.17362488 |
| 66 | MP0002006_tumorigenesis | 1.15406908 |
| 67 | MP0001545_abnormal_hematopoietic_system | 1.14468927 |
| 68 | MP0005397_hematopoietic_system_phenotyp | 1.14468927 |
| 69 | MP0002060_abnormal_skin_morphology | 1.13957943 |
| 70 | MP0003937_abnormal_limbs/digits/tail_de | 1.13381747 |
| 71 | MP0005248_abnormal_Harderian_gland | 1.11344046 |
| 72 | MP0000428_abnormal_craniofacial_morphol | 1.11032666 |
| 73 | MP0000627_abnormal_mammary_gland | 1.10954152 |
| 74 | MP0003453_abnormal_keratinocyte_physiol | 1.10474096 |
| 75 | MP0010234_abnormal_vibrissa_follicle | 1.10338269 |
| 76 | MP0000432_abnormal_head_morphology | 1.10243386 |
| 77 | MP0008932_abnormal_embryonic_tissue | 1.08132621 |
| 78 | MP0000733_abnormal_muscle_development | 1.08012409 |
| 79 | MP0000703_abnormal_thymus_morphology | 1.07808809 |
| 80 | MP0001915_intracranial_hemorrhage | 1.04888807 |
| 81 | MP0003567_abnormal_fetal_cardiomyocyte | 1.03037036 |
| 82 | MP0000427_abnormal_hair_cycle | 1.02409288 |
| 83 | MP0003115_abnormal_respiratory_system | 1.01554239 |
| 84 | MP0004233_abnormal_muscle_weight | 1.00891926 |
| 85 | MP0003868_abnormal_feces_composition | 0.99960612 |
| 86 | MP0001348_abnormal_lacrimal_gland | 0.99412182 |
| 87 | MP0000762_abnormal_tongue_morphology | 0.97814133 |
| 88 | MP0002092_abnormal_eye_morphology | 0.96990656 |
| 89 | MP0000377_abnormal_hair_follicle | 0.96617171 |
| 90 | MP0009672_abnormal_birth_weight | 0.96526495 |
| 91 | MP0002925_abnormal_cardiovascular_devel | 0.93838251 |
| 92 | MP0000313_abnormal_cell_death | 0.93410004 |
| 93 | MP0002796_impaired_skin_barrier | 0.92479518 |
| 94 | MP0002019_abnormal_tumor_incidence | 0.91618358 |
| 95 | MP0005367_renal/urinary_system_phenotyp | 0.90919622 |
| 96 | MP0000516_abnormal_urinary_system | 0.90919622 |
| 97 | MP0001216_abnormal_epidermal_layer | 0.90413825 |
| 98 | MP0005384_cellular_phenotype | 0.89533074 |
| 99 | MP0001119_abnormal_female_reproductive | 0.89166508 |
| 100 | MP0003385_abnormal_body_wall | 0.87043104 |
| 101 | MP0000490_abnormal_crypts_of | 0.85821441 |
| 102 | MP0002098_abnormal_vibrissa_morphology | 0.85725185 |
| 103 | MP0000579_abnormal_nail_morphology | 0.85261305 |
| 104 | MP0000003_abnormal_adipose_tissue | 0.85232027 |
| 105 | MP0003755_abnormal_palate_morphology | 0.84832991 |
| 106 | MP0002398_abnormal_bone_marrow | 0.83563152 |
| 107 | MP0003091_abnormal_cell_migration | 0.83202792 |
| 108 | MP0003566_abnormal_cell_adhesion | 0.81047658 |
| 109 | MP0005501_abnormal_skin_physiology | 0.80809345 |
| 110 | MP0001849_ear_inflammation | 0.80339359 |
| 111 | MP0002697_abnormal_eye_size | 0.79644628 |
| 112 | MP0003943_abnormal_hepatobiliary_system | 0.78945664 |
| 113 | MP0004134_abnormal_chest_morphology | 0.78832774 |
| 114 | MP0002161_abnormal_fertility/fecundity | 0.77221853 |
| 115 | MP0005408_hypopigmentation | 0.77156175 |
| 116 | MP0002116_abnormal_craniofacial_bone | 0.77073379 |
| 117 | MP0003221_abnormal_cardiomyocyte_apopto | 0.75887682 |
| 118 | MP0002269_muscular_atrophy | 0.75534551 |
| 119 | MP0005621_abnormal_cell_physiology | 0.75103435 |
| 120 | MP0002928_abnormal_bile_duct | 0.72943079 |
| 121 | MP0000371_diluted_coat_color | 0.72696699 |
| 122 | MP0003045_fibrosis | 0.72596796 |
| 123 | MP0005395_other_phenotype | 0.72524083 |
| 124 | MP0005275_abnormal_skin_tensile | 0.71582948 |
| 125 | MP0002109_abnormal_limb_morphology | 0.71565811 |
| 126 | MP0000537_abnormal_urethra_morphology | 0.71565212 |
| 127 | MP0005187_abnormal_penis_morphology | 0.71304812 |
| 128 | MP0010630_abnormal_cardiac_muscle | 0.70988916 |
| 129 | MP0004084_abnormal_cardiac_muscle | 0.70741964 |
| 130 | MP0002938_white_spotting | 0.70728477 |
| 131 | MP0003936_abnormal_reproductive_system | 0.70582506 |
| 132 | MP0005023_abnormal_wound_healing | 0.70439322 |
| 133 | MP0003699_abnormal_female_reproductive | 0.68225234 |
| 134 | MP0005623_abnormal_meninges_morphology | 0.67860885 |
| 135 | MP0001286_abnormal_eye_development | 0.66765617 |
| 136 | MP0009780_abnormal_chondrocyte_physiolo | 0.66502401 |
| 137 | MP0002111_abnormal_tail_morphology | 0.66254429 |
| 138 | MP0001346_abnormal_lacrimal_gland | 0.63703453 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 3.98222442 |
| 2 | Abnormality of the fingertips (HP:0001211) | 3.59111103 |
| 3 | Facial hemangioma (HP:0000329) | 3.31811483 |
| 4 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.14595714 |
| 5 | Short 4th metacarpal (HP:0010044) | 3.14595714 |
| 6 | Papillary thyroid carcinoma (HP:0002895) | 2.88374051 |
| 7 | Asymmetry of the thorax (HP:0001555) | 2.86075259 |
| 8 | Dysmetric saccades (HP:0000641) | 2.77403673 |
| 9 | Sparse lateral eyebrow (HP:0005338) | 2.67486513 |
| 10 | Ectopic kidney (HP:0000086) | 2.64672674 |
| 11 | Ankyloglossia (HP:0010296) | 2.56622386 |
| 12 | Medulloblastoma (HP:0002885) | 2.53778326 |
| 13 | Abnormality of the astrocytes (HP:0100707) | 2.53346440 |
| 14 | Astrocytoma (HP:0009592) | 2.53346440 |
| 15 | Long eyelashes (HP:0000527) | 2.47810029 |
| 16 | Chromsome breakage (HP:0040012) | 2.46280678 |
| 17 | Heterotopia (HP:0002282) | 2.43181161 |
| 18 | Embryonal renal neoplasm (HP:0011794) | 2.43073339 |
| 19 | Colon cancer (HP:0003003) | 2.42715147 |
| 20 | Absent frontal sinuses (HP:0002688) | 2.40524234 |
| 21 | Macroorchidism (HP:0000053) | 2.39195282 |
| 22 | Subacute progressive viral hepatitis (HP:0006572) | 2.34963698 |
| 23 | Abnormality of oral frenula (HP:0000190) | 2.31609719 |
| 24 | Overlapping toe (HP:0001845) | 2.29228034 |
| 25 | Broad thumb (HP:0011304) | 2.27087537 |
| 26 | Neoplasm of the oral cavity (HP:0100649) | 2.26673470 |
| 27 | Acute myeloid leukemia (HP:0004808) | 2.24589942 |
| 28 | Glioma (HP:0009733) | 2.24475459 |
| 29 | Flat acetabular roof (HP:0003180) | 2.23496774 |
| 30 | Abnormal foot bone ossification (HP:0010675) | 2.22395785 |
| 31 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.20533146 |
| 32 | Relative macrocephaly (HP:0004482) | 2.20074531 |
| 33 | Increased nuchal translucency (HP:0010880) | 2.18976761 |
| 34 | Abnormality of the labia minora (HP:0012880) | 2.17795706 |
| 35 | Abnormality of the 4th metacarpal (HP:0010012) | 2.17468125 |
| 36 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.16432669 |
| 37 | Osteolytic defects of the hand bones (HP:0009699) | 2.16432669 |
| 38 | Prominent nose (HP:0000448) | 2.15887072 |
| 39 | Abnormality of chromosome stability (HP:0003220) | 2.15128112 |
| 40 | Deviation of the thumb (HP:0009603) | 2.12440238 |
| 41 | Cubitus valgus (HP:0002967) | 2.10280623 |
| 42 | Truncal obesity (HP:0001956) | 2.09437143 |
| 43 | Deep philtrum (HP:0002002) | 2.08579172 |
| 44 | Abnormality of the preputium (HP:0100587) | 2.08287549 |
| 45 | Insidious onset (HP:0003587) | 2.08165007 |
| 46 | Termporal pattern (HP:0011008) | 2.08165007 |
| 47 | Ependymoma (HP:0002888) | 2.06129412 |
| 48 | Selective tooth agenesis (HP:0001592) | 2.05309603 |
| 49 | Sandal gap (HP:0001852) | 2.04381008 |
| 50 | Curly hair (HP:0002212) | 2.02369873 |
| 51 | Entropion (HP:0000621) | 2.01935016 |
| 52 | Syringomyelia (HP:0003396) | 2.00225305 |
| 53 | Spinal cord lesions (HP:0100561) | 2.00225305 |
| 54 | Broad palm (HP:0001169) | 1.99568990 |
| 55 | Microglossia (HP:0000171) | 1.98774841 |
| 56 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.98598407 |
| 57 | Cystic hygroma (HP:0000476) | 1.98585148 |
| 58 | Hypoplastic ischia (HP:0003175) | 1.97677258 |
| 59 | Abnormality of the nasal septum (HP:0000419) | 1.97496093 |
| 60 | Abnormality of chromosome segregation (HP:0002916) | 1.95624113 |
| 61 | Trigonocephaly (HP:0000243) | 1.94441978 |
| 62 | Hypoplastic labia majora (HP:0000059) | 1.93267439 |
| 63 | Broad phalanges of the hand (HP:0009768) | 1.92524235 |
| 64 | Male infertility (HP:0003251) | 1.92344479 |
| 65 | Basal cell carcinoma (HP:0002671) | 1.92200975 |
| 66 | Neoplasm of the adrenal cortex (HP:0100641) | 1.92120407 |
| 67 | Urethral obstruction (HP:0000796) | 1.91979848 |
| 68 | Hyperacusis (HP:0010780) | 1.91765183 |
| 69 | Gastrointestinal carcinoma (HP:0002672) | 1.91659217 |
| 70 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.91659217 |
| 71 | Overgrowth (HP:0001548) | 1.91608095 |
| 72 | Right ventricular cardiomyopathy (HP:0011663) | 1.91024672 |
| 73 | Septate vagina (HP:0001153) | 1.89280141 |
| 74 | Hypopigmentation of the fundus (HP:0007894) | 1.89165037 |
| 75 | Narrow palate (HP:0000189) | 1.88201848 |
| 76 | Proximal placement of thumb (HP:0009623) | 1.87641988 |
| 77 | Vertebral arch anomaly (HP:0008438) | 1.86106868 |
| 78 | Advanced eruption of teeth (HP:0006288) | 1.83273686 |
| 79 | Biliary tract neoplasm (HP:0100574) | 1.81894326 |
| 80 | Abnormality of the epiphyses of the phalanges of the hand (HP:0005920) | 1.79697153 |
| 81 | Leiomyosarcoma (HP:0100243) | 1.79592875 |
| 82 | Uterine leiomyosarcoma (HP:0002891) | 1.79592875 |
| 83 | Abnormality of the lower motor neuron (HP:0002366) | 1.79096245 |
| 84 | Impulsivity (HP:0100710) | 1.78446388 |
| 85 | Rhabdomyosarcoma (HP:0002859) | 1.78415964 |
| 86 | Skull defect (HP:0001362) | 1.78057533 |
| 87 | Rib fusion (HP:0000902) | 1.77973344 |
| 88 | Neonatal hypoglycemia (HP:0001998) | 1.77662316 |
| 89 | Cerebral aneurysm (HP:0004944) | 1.77071232 |
| 90 | Limited elbow extension (HP:0001377) | 1.77016205 |
| 91 | Broad phalanx (HP:0006009) | 1.76970677 |
| 92 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.76955075 |
| 93 | 11 pairs of ribs (HP:0000878) | 1.76402872 |
| 94 | Ulnar bowing (HP:0003031) | 1.75863969 |
| 95 | Capillary hemangiomas (HP:0005306) | 1.75600534 |
| 96 | Hematochezia (HP:0002573) | 1.75438692 |
| 97 | Natal tooth (HP:0000695) | 1.75296004 |
| 98 | Progressive external ophthalmoplegia (HP:0000590) | 1.75210135 |
| 99 | Dislocated radial head (HP:0003083) | 1.74854131 |
| 100 | Abnormality of the epiphyses of the hand (HP:0005924) | 1.73981508 |
| 101 | Short chin (HP:0000331) | 1.73151429 |
| 102 | Broad finger (HP:0001500) | 1.72279065 |
| 103 | Abnormality of the labia majora (HP:0012881) | 1.71666073 |
| 104 | Missing ribs (HP:0000921) | 1.71548708 |
| 105 | Short humerus (HP:0005792) | 1.71428791 |
| 106 | Bladder carcinoma (HP:0002862) | 1.70623815 |
| 107 | Bladder neoplasm (HP:0009725) | 1.70623815 |
| 108 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.70155685 |
| 109 | Myelodysplasia (HP:0002863) | 1.70040423 |
| 110 | Cafe-au-lait spot (HP:0000957) | 1.69773433 |
| 111 | Hepatoblastoma (HP:0002884) | 1.69466978 |
| 112 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.69098829 |
| 113 | Anal stenosis (HP:0002025) | 1.68998899 |
| 114 | Premature rupture of membranes (HP:0001788) | 1.68364559 |
| 115 | High anterior hairline (HP:0009890) | 1.68208656 |
| 116 | Lip pit (HP:0100267) | 1.68129009 |
| 117 | Short 5th finger (HP:0009237) | 1.67912756 |
| 118 | Mitral valve prolapse (HP:0001634) | 1.67337821 |
| 119 | Abnormality of the ileum (HP:0001549) | 1.66803628 |
| 120 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.66424943 |
| 121 | Thyroid carcinoma (HP:0002890) | 1.66188314 |
| 122 | Abnormality of the ischium (HP:0003174) | 1.65352162 |
| 123 | Abnormality involving the epiphyses of the upper limbs (HP:0003839) | 1.65101294 |
| 124 | Shallow orbits (HP:0000586) | 1.64925866 |
| 125 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.64881766 |
| 126 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.63734731 |
| 127 | Rectal prolapse (HP:0002035) | 1.63258864 |
| 128 | Increased number of teeth (HP:0011069) | 1.63054716 |
| 129 | Metaphyseal cupping (HP:0003021) | 1.62943966 |
| 130 | Low anterior hairline (HP:0000294) | 1.62925672 |
| 131 | Broad long bones (HP:0005622) | 1.62925215 |
| 132 | Renovascular hypertension (HP:0100817) | 1.62599430 |
| 133 | Abnormal spermatogenesis (HP:0008669) | 1.62412646 |
| 134 | Abnormality of the calcaneus (HP:0008364) | 1.62323146 |
| 135 | Neoplasm of striated muscle (HP:0009728) | 1.62149067 |
| 136 | Obsessive-compulsive behavior (HP:0000722) | 1.61958547 |
| 137 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.61659932 |
| 138 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.61115480 |
| 139 | Renal duplication (HP:0000075) | 1.60866708 |
| 140 | Smooth philtrum (HP:0000319) | 1.60572229 |
| 141 | Abnormality of the radial head (HP:0003995) | 1.60303012 |
| 142 | Poikiloderma (HP:0001029) | 1.60296792 |
| 143 | Abnormality of the carotid arteries (HP:0005344) | 1.60091088 |
| 144 | Patellar aplasia (HP:0006443) | 1.57095323 |
| 145 | Thick eyebrow (HP:0000574) | 1.55988648 |
| 146 | Meckel diverticulum (HP:0002245) | 1.55616532 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 4.89633989 |
| 2 | LATS1 | 3.71446048 |
| 3 | CDC7 | 3.58310711 |
| 4 | MST1R | 2.45110066 |
| 5 | NEK2 | 2.41996506 |
| 6 | TRIB3 | 2.41581171 |
| 7 | ICK | 2.35745949 |
| 8 | BRD4 | 2.31351236 |
| 9 | EIF2AK3 | 2.27620173 |
| 10 | STK3 | 2.04815147 |
| 11 | MAP3K10 | 1.95504058 |
| 12 | MET | 1.94067053 |
| 13 | BRSK2 | 1.91366701 |
| 14 | PBK | 1.87572200 |
| 15 | ATR | 1.80197087 |
| 16 | CAMK1D | 1.66360786 |
| 17 | CAMK1G | 1.64573598 |
| 18 | EEF2K | 1.60957107 |
| 19 | SMG1 | 1.60920424 |
| 20 | CHEK2 | 1.55387540 |
| 21 | CHEK1 | 1.54099252 |
| 22 | ACVR1B | 1.53671855 |
| 23 | DDR2 | 1.51736254 |
| 24 | CDK6 | 1.48528024 |
| 25 | EIF2AK1 | 1.47121732 |
| 26 | FRK | 1.46615110 |
| 27 | MAP3K6 | 1.43746702 |
| 28 | MTOR | 1.40629941 |
| 29 | PDGFRA | 1.40575486 |
| 30 | ATM | 1.37965504 |
| 31 | SRPK1 | 1.34191919 |
| 32 | CDK7 | 1.32948827 |
| 33 | NEK6 | 1.32754781 |
| 34 | FGFR3 | 1.32442600 |
| 35 | PASK | 1.32205118 |
| 36 | AKT3 | 1.31145508 |
| 37 | BUB1 | 1.29046181 |
| 38 | MELK | 1.28194842 |
| 39 | STK38L | 1.28037684 |
| 40 | PDK4 | 1.26083478 |
| 41 | PDK3 | 1.26083478 |
| 42 | NEK9 | 1.24792705 |
| 43 | TYRO3 | 1.23105680 |
| 44 | PLK1 | 1.22942859 |
| 45 | TTK | 1.22150776 |
| 46 | MAP3K13 | 1.21028738 |
| 47 | MKNK2 | 1.18336661 |
| 48 | MAP3K9 | 1.16871929 |
| 49 | SCYL2 | 1.16336830 |
| 50 | WEE1 | 1.11706155 |
| 51 | PIM1 | 1.11017592 |
| 52 | PLK4 | 1.09930489 |
| 53 | JAK3 | 1.08522092 |
| 54 | CDK9 | 1.08302662 |
| 55 | IRAK3 | 1.08051544 |
| 56 | CDK4 | 1.05920050 |
| 57 | STK10 | 1.05863464 |
| 58 | LATS2 | 1.04584647 |
| 59 | PDGFRB | 1.01342301 |
| 60 | PRKD3 | 1.01220118 |
| 61 | CDK2 | 1.00325529 |
| 62 | PLK3 | 0.99270094 |
| 63 | RPS6KA4 | 0.98646195 |
| 64 | CHUK | 0.98151032 |
| 65 | KSR2 | 0.98131906 |
| 66 | AURKB | 0.97210557 |
| 67 | MKNK1 | 0.94811973 |
| 68 | TAF1 | 0.94115543 |
| 69 | RIPK1 | 0.93247481 |
| 70 | NUAK1 | 0.92663554 |
| 71 | WNK1 | 0.91888209 |
| 72 | FGFR4 | 0.91758369 |
| 73 | KSR1 | 0.90764784 |
| 74 | FGFR1 | 0.88110613 |
| 75 | PTK2 | 0.83390310 |
| 76 | MARK3 | 0.82168885 |
| 77 | MST4 | 0.82159511 |
| 78 | NEK1 | 0.81401753 |
| 79 | CDK1 | 0.81379267 |
| 80 | DYRK3 | 0.80883002 |
| 81 | PNCK | 0.80476584 |
| 82 | ALK | 0.78723210 |
| 83 | RPS6KB2 | 0.78097638 |
| 84 | TGFBR1 | 0.76772963 |
| 85 | MAP4K1 | 0.76672999 |
| 86 | MAP3K2 | 0.75001725 |
| 87 | STK4 | 0.74350018 |
| 88 | MAP3K14 | 0.74165794 |
| 89 | CDK8 | 0.74131291 |
| 90 | RAF1 | 0.74105616 |
| 91 | ERBB3 | 0.72992690 |
| 92 | PKN2 | 0.70605648 |
| 93 | MAPK11 | 0.69794231 |
| 94 | FGFR2 | 0.69229748 |
| 95 | DYRK1B | 0.68333591 |
| 96 | PTK6 | 0.67693570 |
| 97 | RPS6KB1 | 0.66979706 |
| 98 | ERBB4 | 0.66427597 |
| 99 | BRAF | 0.65741053 |
| 100 | EIF2AK2 | 0.65005899 |
| 101 | BMX | 0.63828725 |
| 102 | PRKDC | 0.63493420 |
| 103 | MAPK14 | 0.62266348 |
| 104 | STK24 | 0.59991036 |
| 105 | TSSK6 | 0.56250621 |
| 106 | PRPF4B | 0.56054007 |
| 107 | CSNK1A1L | 0.55122030 |
| 108 | RET | 0.55014154 |
| 109 | CDC42BPA | 0.54850180 |
| 110 | MAP3K8 | 0.54114050 |
| 111 | CSNK1D | 0.53850092 |
| 112 | PAK4 | 0.53618866 |
| 113 | CSK | 0.52785923 |
| 114 | FLT3 | 0.52580881 |
| 115 | TTN | 0.52522709 |
| 116 | CLK1 | 0.51219934 |
| 117 | MAPK1 | 0.50570143 |
| 118 | DMPK | 0.49653453 |
| 119 | JAK1 | 0.48547373 |
| 120 | GSK3B | 0.48418816 |
| 121 | PRKAA1 | 0.48269812 |
| 122 | TAOK3 | 0.48116370 |
| 123 | MAPK10 | 0.47934643 |
| 124 | PRKD2 | 0.47131830 |
| 125 | TRPM7 | 0.44924160 |
| 126 | AKT1 | 0.44605919 |
| 127 | SIK1 | 0.44504943 |
| 128 | BRSK1 | 0.44236222 |
| 129 | EPHA2 | 0.43992708 |
| 130 | PAK2 | 0.43705868 |
| 131 | SGK3 | 0.43551200 |
| 132 | PIK3CA | 0.42552988 |
| 133 | STK39 | 0.41440112 |
| 134 | ZAK | 0.41348740 |
| 135 | RPS6KA1 | 0.41249606 |
| 136 | NLK | 0.40865834 |
| 137 | CSNK1E | 0.39225856 |
| 138 | PDK2 | 0.38100098 |
| 139 | AURKA | 0.37745495 |
| 140 | MAPK15 | 0.36602851 |
| 141 | HIPK2 | 0.36576913 |
| 142 | BMPR2 | 0.36006053 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RNA transport_Homo sapiens_hsa03013 | 2.48823260 |
| 2 | Cell cycle_Homo sapiens_hsa04110 | 2.48318968 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.45302826 |
| 4 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.33678891 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.08761115 |
| 6 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.03943282 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 1.84799166 |
| 8 | DNA replication_Homo sapiens_hsa03030 | 1.84243426 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 1.76970469 |
| 10 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.73557022 |
| 11 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.68666724 |
| 12 | Lysine degradation_Homo sapiens_hsa00310 | 1.68312667 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 1.63189402 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 1.62653620 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.59005472 |
| 16 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.58766801 |
| 17 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.56643963 |
| 18 | Adherens junction_Homo sapiens_hsa04520 | 1.54543677 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.49871665 |
| 20 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.44856311 |
| 21 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.44557478 |
| 22 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.40502115 |
| 23 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.39410904 |
| 24 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.38447133 |
| 25 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.37245201 |
| 26 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.35459040 |
| 27 | Colorectal cancer_Homo sapiens_hsa05210 | 1.34576806 |
| 28 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.34423522 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.32337176 |
| 30 | HTLV-I infection_Homo sapiens_hsa05166 | 1.29368016 |
| 31 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.26106768 |
| 32 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.25877207 |
| 33 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.24953253 |
| 34 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.24236277 |
| 35 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.22500777 |
| 36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.21363194 |
| 37 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.21125976 |
| 38 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.18303383 |
| 39 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.14090969 |
| 40 | Prostate cancer_Homo sapiens_hsa05215 | 1.10355709 |
| 41 | Endometrial cancer_Homo sapiens_hsa05213 | 1.08616448 |
| 42 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.07998104 |
| 43 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.07680406 |
| 44 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.06594834 |
| 45 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.05549106 |
| 46 | Viral myocarditis_Homo sapiens_hsa05416 | 1.05049596 |
| 47 | Hepatitis B_Homo sapiens_hsa05161 | 1.03279344 |
| 48 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.00480018 |
| 49 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.97507787 |
| 50 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.97373360 |
| 51 | Measles_Homo sapiens_hsa05162 | 0.95333141 |
| 52 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.94532593 |
| 53 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.94505126 |
| 54 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.93214949 |
| 55 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.93051447 |
| 56 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.92935408 |
| 57 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.92621496 |
| 58 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.90438647 |
| 59 | Melanoma_Homo sapiens_hsa05218 | 0.89121866 |
| 60 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.88187931 |
| 61 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.85791441 |
| 62 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.85365407 |
| 63 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.85109945 |
| 64 | Thyroid cancer_Homo sapiens_hsa05216 | 0.85049771 |
| 65 | Influenza A_Homo sapiens_hsa05164 | 0.82412390 |
| 66 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.81262631 |
| 67 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.78822012 |
| 68 | Focal adhesion_Homo sapiens_hsa04510 | 0.77868321 |
| 69 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.76149458 |
| 70 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.75670571 |
| 71 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.74785059 |
| 72 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.74118774 |
| 73 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.73616037 |
| 74 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.73111054 |
| 75 | Pathways in cancer_Homo sapiens_hsa05200 | 0.71943474 |
| 76 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.69764049 |
| 77 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.66590641 |
| 78 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.64416160 |
| 79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.64240399 |
| 80 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.63771340 |
| 81 | Circadian rhythm_Homo sapiens_hsa04710 | 0.63713154 |
| 82 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.62503225 |
| 83 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.61916208 |
| 84 | Apoptosis_Homo sapiens_hsa04210 | 0.59816836 |
| 85 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.59751741 |
| 86 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.58947718 |
| 87 | Alcoholism_Homo sapiens_hsa05034 | 0.57842093 |
| 88 | Tight junction_Homo sapiens_hsa04530 | 0.57501204 |
| 89 | Glioma_Homo sapiens_hsa05214 | 0.56926432 |
| 90 | Insulin resistance_Homo sapiens_hsa04931 | 0.55977035 |
| 91 | Shigellosis_Homo sapiens_hsa05131 | 0.54106539 |
| 92 | Hepatitis C_Homo sapiens_hsa05160 | 0.53956330 |
| 93 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.53173259 |
| 94 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.52558302 |
| 95 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.52235473 |
| 96 | Legionellosis_Homo sapiens_hsa05134 | 0.51518538 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.50737242 |
| 98 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.49815200 |
| 99 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.49753554 |
| 100 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.49527815 |
| 101 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.49438398 |
| 102 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.49356692 |
| 103 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.49008606 |
| 104 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.48719082 |
| 105 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.48678823 |
| 106 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.48331111 |
| 107 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.48296300 |
| 108 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.47442662 |
| 109 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.46319089 |
| 110 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.46218380 |
| 111 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.45753325 |
| 112 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.44947730 |
| 113 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.44763250 |
| 114 | Bladder cancer_Homo sapiens_hsa05219 | 0.44562791 |
| 115 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.42411246 |
| 116 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39807403 |

