FAM209B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.10217940
2DNA packaging (GO:0006323)8.77856021
3sperm capacitation (GO:0048240)8.72064073
4response to pheromone (GO:0019236)8.65424665
5single strand break repair (GO:0000012)8.19351670
6plasma membrane fusion (GO:0045026)8.17946011
7microtubule depolymerization (GO:0007019)8.16080933
8sperm-egg recognition (GO:0035036)7.65863275
9spermatid development (GO:0007286)7.60554630
10spermatid nucleus differentiation (GO:0007289)7.52340572
11binding of sperm to zona pellucida (GO:0007339)7.19619834
12protein targeting to Golgi (GO:0000042)7.01985280
13rRNA methylation (GO:0031167)6.81520842
14protein polyglutamylation (GO:0018095)6.80999245
15multicellular organism reproduction (GO:0032504)6.79817846
16establishment of protein localization to Golgi (GO:0072600)6.77635802
17microtubule polymerization or depolymerization (GO:0031109)6.64115621
18sexual reproduction (GO:0019953)6.52430915
19reproduction (GO:0000003)6.48012530
20retrograde transport, vesicle recycling within Golgi (GO:0000301)6.40708285
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.37107310
22calcium ion-dependent exocytosis (GO:0017156)6.29425384
23cell-cell recognition (GO:0009988)6.28493228
24axonemal dynein complex assembly (GO:0070286)6.28050040
25negative regulation of inclusion body assembly (GO:0090084)6.16786698
26spermatogenesis (GO:0007283)6.14760623
27male gamete generation (GO:0048232)6.12317418
28phosphatidylethanolamine biosynthetic process (GO:0006646)5.93014625
29protein localization to Golgi apparatus (GO:0034067)5.81577255
30centriole replication (GO:0007099)5.77660709
31rRNA modification (GO:0000154)5.70887596
32gamete generation (GO:0007276)5.61914440
33phosphatidylethanolamine metabolic process (GO:0046337)5.42526355
34regulation of cilium movement (GO:0003352)5.33038449
35RNA destabilization (GO:0050779)5.21272583
36cell wall macromolecule catabolic process (GO:0016998)5.11673050
37cellular ketone body metabolic process (GO:0046950)5.07872090
38single fertilization (GO:0007338)5.02517286
39centriole assembly (GO:0098534)4.94090696
40microtubule severing (GO:0051013)4.92051685
41regulation of Rab GTPase activity (GO:0032313)4.82063546
42positive regulation of Rab GTPase activity (GO:0032851)4.82063546
43cell wall macromolecule metabolic process (GO:0044036)4.65330451
44cilium or flagellum-dependent cell motility (GO:0001539)4.62856543
45motile cilium assembly (GO:0044458)4.58910202
46multicellular organismal reproductive process (GO:0048609)4.48770888
47chromatin silencing (GO:0006342)4.45699436
48ketone body metabolic process (GO:1902224)4.44920856
49germ cell development (GO:0007281)4.36619949
50seminiferous tubule development (GO:0072520)4.34032542
51fertilization (GO:0009566)4.33141791
52regulation of T-helper 2 cell differentiation (GO:0045628)4.30810372
53regulation of inclusion body assembly (GO:0090083)4.28121817
54negative regulation of Rho protein signal transduction (GO:0035024)4.22474820
55cellular process involved in reproduction in multicellular organism (GO:0022412)4.17226444
56regulation of centriole replication (GO:0046599)4.13609775
57epithelial cilium movement (GO:0003351)3.91858139
58nucleus organization (GO:0006997)3.91701396
59glycerol ether metabolic process (GO:0006662)3.83188740
60regulation of transcription involved in cell fate commitment (GO:0060850)3.69984176
61coenzyme catabolic process (GO:0009109)3.59170294
62regulation of microtubule-based movement (GO:0060632)3.57475413
63ether metabolic process (GO:0018904)3.50503793
64regulation of interleukin-13 production (GO:0032656)3.34706123
65glomerular visceral epithelial cell development (GO:0072015)3.34630302
66organic cation transport (GO:0015695)3.33054310
67cilium movement (GO:0003341)3.32779570
68male meiosis I (GO:0007141)3.30522081
69polyamine biosynthetic process (GO:0006596)3.29163895
70mitochondrial fission (GO:0000266)3.25972638
71piRNA metabolic process (GO:0034587)3.23507076
72glomerular epithelial cell development (GO:0072310)3.17755344
73receptor recycling (GO:0001881)3.15821344
74mesenchymal cell differentiation involved in kidney development (GO:0072161)3.13806749
75mesenchymal cell differentiation involved in renal system development (GO:2001012)3.13806749
76microtubule nucleation (GO:0007020)3.12583664
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11236898
78negative regulation of gene expression, epigenetic (GO:0045814)3.11023986
79NAD biosynthetic process (GO:0009435)3.08353108
80musculoskeletal movement (GO:0050881)3.05974902
81multicellular organismal movement (GO:0050879)3.05974902
82membrane protein intracellular domain proteolysis (GO:0031293)3.01980199
83RNA methylation (GO:0001510)3.00006176
84cell differentiation involved in metanephros development (GO:0072202)2.99803743
85homeostasis of number of cells within a tissue (GO:0048873)2.99751139
86response to acidic pH (GO:0010447)2.98474421
87DNA methylation involved in gamete generation (GO:0043046)2.98164630
88histone H3-K9 demethylation (GO:0033169)2.97588206
89multicellular organismal development (GO:0007275)2.94341521
90cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.94111562
91negative regulation of granulocyte differentiation (GO:0030853)2.89839067
92cell recognition (GO:0008037)2.87951872
93male meiosis (GO:0007140)2.85767770
94positive regulation of type 2 immune response (GO:0002830)2.80072815
95cellular response to pH (GO:0071467)2.78038714
96regulation of interleukin-5 production (GO:0032674)2.76814835
97DNA conformation change (GO:0071103)2.76639161
98acrosome reaction (GO:0007340)11.4880509
99sperm motility (GO:0030317)11.4753966
100fusion of sperm to egg plasma membrane (GO:0007342)10.8304811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.38354698
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.70214390
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.44573753
4ELF1_20517297_ChIP-Seq_JURKAT_Human2.32936538
5VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.24464430
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.22254926
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22254926
8RUNX_20019798_ChIP-Seq_JUKART_Human2.18274371
9CBP_20019798_ChIP-Seq_JUKART_Human2.13437933
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.13437933
11RAC3_21632823_ChIP-Seq_H3396_Human2.10989994
12ERA_21632823_ChIP-Seq_H3396_Human2.08328058
13RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.05984977
14EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.05884274
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.98728364
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97060125
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91555276
18NANOG_20526341_ChIP-Seq_ESCs_Human1.89345576
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88006785
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86083422
21FUS_26573619_Chip-Seq_HEK293_Human1.85792832
22EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.79220302
23BCL6_27268052_Chip-Seq_Bcells_Human1.78960269
24TAF2_19829295_ChIP-Seq_ESCs_Human1.74772564
25TDRD3_21172665_ChIP-Seq_MCF-7_Human1.74500934
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71505184
27BCOR_27268052_Chip-Seq_Bcells_Human1.69515828
28MYC_19829295_ChIP-Seq_ESCs_Human1.66767184
29E2F1_20622854_ChIP-Seq_HELA_Human1.64510989
30ER_23166858_ChIP-Seq_MCF-7_Human1.59641311
31OCT4_20526341_ChIP-Seq_ESCs_Human1.56768242
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56353670
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.53837480
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52586527
35PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.51142538
36CTCF_20526341_ChIP-Seq_ESCs_Human1.51092885
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50737546
38DROSHA_22980978_ChIP-Seq_HELA_Human1.48368244
39CEBPB_22108803_ChIP-Seq_LS180_Human1.46307556
40P300_27268052_Chip-Seq_Bcells_Human1.45802621
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.44948915
42PHF8_20622854_ChIP-Seq_HELA_Human1.44922781
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.44040197
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.43504971
45P68_20966046_ChIP-Seq_HELA_Human1.42456135
46RBPJ_21746931_ChIP-Seq_IB4_Human1.41606780
47CBX2_22325352_ChIP-Seq_293T-Rex_Human1.40870762
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40228897
49ERG_20517297_ChIP-Seq_VCAP_Human1.39021262
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38570825
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.38016712
52CTCF_27219007_Chip-Seq_Bcells_Human1.37893435
53SMC4_20622854_ChIP-Seq_HELA_Human1.37457353
54VDR_24787735_ChIP-Seq_THP-1_Human1.36530095
55ZNF274_21170338_ChIP-Seq_K562_Hela1.35626655
56TP63_22573176_ChIP-Seq_HFKS_Human1.35259301
57KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.35086495
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33603247
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33411937
60AR_25329375_ChIP-Seq_VCAP_Human1.31393219
61ETV1_20927104_ChIP-Seq_GIST48_Human1.30022817
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29826477
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.29532152
64SMRT_27268052_Chip-Seq_Bcells_Human1.28427519
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.27225188
66P53_21459846_ChIP-Seq_SAOS-2_Human1.23515323
67SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22889099
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21121406
69GATA6_21074721_ChIP-Seq_CACO-2_Human1.19590684
70SALL4_22934838_ChIP-ChIP_CD34+_Human1.18465335
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16689194
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16314716
73NFYB_21822215_ChIP-Seq_K562_Human1.14947791
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.14553345
75SA1_27219007_Chip-Seq_Bcells_Human1.13824239
76SOX2_19829295_ChIP-Seq_ESCs_Human1.13761129
77NANOG_19829295_ChIP-Seq_ESCs_Human1.13761129
78PHF8_20622853_ChIP-Seq_HELA_Human1.13251090
79SMAD3_21741376_ChIP-Seq_ESCs_Human1.12589801
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.12417004
81FOXH1_21741376_ChIP-Seq_ESCs_Human1.10992007
82MYB_26560356_Chip-Seq_TH2_Human1.10702207
83GATA3_26560356_Chip-Seq_TH1_Human1.10293693
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08246964
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.07603265
86TP53_18474530_ChIP-ChIP_U2OS_Human1.07501839
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06755921
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.05912624
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05757604
90TAF15_26573619_Chip-Seq_HEK293_Human1.04915881
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04778096
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04441726
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.04441726
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04299223
95HOXB7_26014856_ChIP-Seq_BT474_Human1.03897949
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03115855
97TBL1_22424771_ChIP-Seq_293T_Human1.01604110
98STAT1_20625510_ChIP-Seq_HELA_Human1.00161758
99E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99842215
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98836880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.84795079
2MP0003878_abnormal_ear_physiology4.84795079
3MP0005670_abnormal_white_adipose4.47467281
4MP0003698_abnormal_male_reproductive4.09223394
5MP0001929_abnormal_gametogenesis3.65132507
6MP0001348_abnormal_lacrimal_gland3.37900680
7MP0002132_abnormal_respiratory_system3.10606623
8MP0008877_abnormal_DNA_methylation2.55766663
9MP0000678_abnormal_parathyroid_gland2.50893274
10MP0003011_delayed_dark_adaptation2.46703065
11MP0003646_muscle_fatigue2.44436344
12MP0002161_abnormal_fertility/fecundity2.22625608
13MP0002138_abnormal_hepatobiliary_system2.16008168
14MP0003718_maternal_effect2.06547498
15MP0005410_abnormal_fertilization11.5564540
16MP0005310_abnormal_salivary_gland1.87375959
17MP0005379_endocrine/exocrine_gland_phen1.79534039
18MP0002210_abnormal_sex_determination1.62680813
19MP0004510_myositis1.52109506
20MP0001145_abnormal_male_reproductive1.34993183
21MP0005423_abnormal_somatic_nervous1.27536497
22MP0000653_abnormal_sex_gland1.26738231
23MP0002282_abnormal_trachea_morphology1.26338459
24MP0002127_abnormal_cardiovascular_syste1.25619392
25MP0001485_abnormal_pinna_reflex1.23945625
26MP0004742_abnormal_vestibular_system1.23849019
27MP0005451_abnormal_body_composition1.22136011
28MP0002234_abnormal_pharynx_morphology1.20472634
29MP0001486_abnormal_startle_reflex1.15174425
30MP0009785_altered_susceptibility_to1.13857299
31MP0001835_abnormal_antigen_presentation1.13017807
32MP0000681_abnormal_thyroid_gland1.09238407
33MP0001765_abnormal_ion_homeostasis1.06953598
34MP0003436_decreased_susceptibility_to0.99426439
35MP0002249_abnormal_larynx_morphology0.98969521
36MP0009764_decreased_sensitivity_to0.95260177
37MP0005084_abnormal_gallbladder_morpholo0.94957864
38MP0002735_abnormal_chemical_nociception0.92346456
39MP0009053_abnormal_anal_canal0.86335207
40MP0005395_other_phenotype0.84880361
41MP0005666_abnormal_adipose_tissue0.84034289
42MP0003172_abnormal_lysosome_physiology0.83363383
43MP0002254_reproductive_system_inflammat0.83022581
44MP0003879_abnormal_hair_cell0.82520283
45MP0002733_abnormal_thermal_nociception0.81683441
46MP0002419_abnormal_innate_immunity0.79648073
47MP0002723_abnormal_immune_serum0.79645036
48MP0001963_abnormal_hearing_physiology0.79446164
49MP0005025_abnormal_response_to0.79177374
50MP0008995_early_reproductive_senescence0.76841586
51MP0001968_abnormal_touch/_nociception0.75432606
52MP0005535_abnormal_body_temperature0.73945819
53MP0009115_abnormal_fat_cell0.73812900
54MP0001800_abnormal_humoral_immune0.73019567
55MP0001545_abnormal_hematopoietic_system0.72247279
56MP0005397_hematopoietic_system_phenotyp0.72247279
57MP0002229_neurodegeneration0.70673234
58MP0005167_abnormal_blood-brain_barrier0.70394142
59MP0003724_increased_susceptibility_to0.68411771
60MP0000703_abnormal_thymus_morphology0.66738724
61MP0005000_abnormal_immune_tolerance0.64557362
62MP0002452_abnormal_antigen_presenting0.63464731
63MP0004036_abnormal_muscle_relaxation0.63163812
64MP0001853_heart_inflammation0.63103563
65MP0005647_abnormal_sex_gland0.62969644
66MP0005375_adipose_tissue_phenotype0.61541070
67MP0009278_abnormal_bone_marrow0.61064956
68MP0005636_abnormal_mineral_homeostasis0.60973637
69MP0005671_abnormal_response_to0.57642238
70MP0000249_abnormal_blood_vessel0.56936772
71MP0002420_abnormal_adaptive_immunity0.56361373
72MP0001970_abnormal_pain_threshold0.56137460
73MP0005248_abnormal_Harderian_gland0.55981795
74MP0005166_decreased_susceptibility_to0.55249567
75MP0005083_abnormal_biliary_tract0.55020011
76MP0005253_abnormal_eye_physiology0.54812958
77MP0004859_abnormal_synaptic_plasticity0.54126309
78MP0001819_abnormal_immune_cell0.54017139
79MP0001764_abnormal_homeostasis0.53257684
80MP0005551_abnormal_eye_electrophysiolog0.52817590
81MP0002722_abnormal_immune_system0.51478003
82MP0008469_abnormal_protein_level0.51370825
83MP0000026_abnormal_inner_ear0.50973360
84MP0002928_abnormal_bile_duct0.50571649
85MP0002148_abnormal_hypersensitivity_rea0.50094384
86MP0001845_abnormal_inflammatory_respons0.47723127
87MP0002398_abnormal_bone_marrow0.47707755
88MP0002405_respiratory_system_inflammati0.47686758
89MP0004782_abnormal_surfactant_physiolog0.47139783
90MP0001873_stomach_inflammation0.45601276
91MP0001533_abnormal_skeleton_physiology0.45254869
92MP0000613_abnormal_salivary_gland0.44768372
93MP0000716_abnormal_immune_system0.44701188
94MP0001984_abnormal_olfaction0.43754160
95MP0000230_abnormal_systemic_arterial0.43727703
96MP0002067_abnormal_sensory_capabilities0.43653785
97MP0004085_abnormal_heartbeat0.43346989
98MP0001790_abnormal_immune_system0.42747127
99MP0005387_immune_system_phenotype0.42747127
100MP0001666_abnormal_nutrient_absorption0.42485799

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.66567657
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.41707429
3Absent/shortened dynein arms (HP:0200106)6.41707429
4Asymmetric septal hypertrophy (HP:0001670)5.05675845
5Attenuation of retinal blood vessels (HP:0007843)4.92804182
6Abnormal ciliary motility (HP:0012262)4.81760153
7Abnormal respiratory motile cilium morphology (HP:0005938)4.76617003
8Abnormal respiratory epithelium morphology (HP:0012253)4.76617003
9Abnormal respiratory motile cilium physiology (HP:0012261)4.69303565
10Tubulointerstitial nephritis (HP:0001970)4.64479324
11Resting tremor (HP:0002322)4.57528876
12Chronic hepatic failure (HP:0100626)4.52102479
13Nasal polyposis (HP:0100582)4.51690810
14Enlarged epiphyses (HP:0010580)4.50149781
15Bony spicule pigmentary retinopathy (HP:0007737)4.40177047
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.29584396
17Infertility (HP:0000789)4.27997537
18Abnormality of macular pigmentation (HP:0008002)4.17353558
19Abnormal rod and cone electroretinograms (HP:0008323)4.13910843
20Hyperkalemia (HP:0002153)3.98267528
21Male infertility (HP:0003251)3.80242276
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.77396776
23Abnormality of the costochondral junction (HP:0000919)3.71105751
24Cone-rod dystrophy (HP:0000548)3.64922424
25Abnormality of the nasal mucosa (HP:0000433)3.63278170
26Facial shape deformation (HP:0011334)3.52829903
27Potter facies (HP:0002009)3.52829903
28Abnormal spermatogenesis (HP:0008669)3.51817138
29Azoospermia (HP:0000027)3.43394757
30Bell-shaped thorax (HP:0001591)3.39402955
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.23319039
32Hypoplastic ischia (HP:0003175)3.17719182
33Abnormality of dental color (HP:0011073)3.14395634
34Hypoplasia of the thymus (HP:0000778)2.96300455
35Postural instability (HP:0002172)2.83651500
36Amelogenesis imperfecta (HP:0000705)2.71513393
37Unilateral renal agenesis (HP:0000122)2.69117046
38Abnormality of the ischium (HP:0003174)2.63986887
39Bronchiectasis (HP:0002110)2.63554858
40Impulsivity (HP:0100710)2.63321253
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.62593188
42Rhinitis (HP:0012384)2.62321319
43Menstrual irregularities (HP:0000858)2.59138191
44Abnormal urine output (HP:0012590)2.55699539
45Hypoalphalipoproteinemia (HP:0003233)2.48629070
46Recurrent pneumonia (HP:0006532)2.48613101
47Progressive sensorineural hearing impairment (HP:0000408)2.46979485
48Progressive cerebellar ataxia (HP:0002073)2.46542301
49Widely patent fontanelles and sutures (HP:0004492)2.44740866
50Stage 5 chronic kidney disease (HP:0003774)2.41672989
51Nephronophthisis (HP:0000090)2.39905341
52Truncal obesity (HP:0001956)2.30321269
53Abnormal drinking behavior (HP:0030082)2.27371875
54Polydipsia (HP:0001959)2.27371875
55Abnormality of the pubic bones (HP:0003172)2.24012875
56Generalized aminoaciduria (HP:0002909)2.19348620
57Abnormality of renal excretion (HP:0011036)2.18263959
58Abnormality of the aortic arch (HP:0012303)2.17844810
59Metaphyseal dysplasia (HP:0100255)2.16524631
60Abnormality of the epiphysis of the femoral head (HP:0010574)2.12270438
61Polyuria (HP:0000103)2.12108167
62Abnormality of potassium homeostasis (HP:0011042)2.11759804
63Tetany (HP:0001281)2.07128627
64Insulin-resistant diabetes mellitus (HP:0000831)2.05622740
65Renal dysplasia (HP:0000110)2.05382180
66Osteomalacia (HP:0002749)2.04280365
67Tubulointerstitial abnormality (HP:0001969)2.03683491
68Gastrointestinal infarctions (HP:0005244)2.01622093
69Portal hypertension (HP:0001409)2.00141303
70Abnormality of the femoral head (HP:0003368)1.96946836
71Ventricular tachycardia (HP:0004756)1.96266094
72Abnormality of the renal medulla (HP:0100957)1.95738292
73Double outlet right ventricle (HP:0001719)1.90937049
74Congenital malformation of the right heart (HP:0011723)1.90937049
75Abnormality of femoral epiphyses (HP:0006499)1.90555939
76Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90555939
77Chronic bronchitis (HP:0004469)1.90458211
78Hyperuricemia (HP:0002149)1.88067849
79Increased purine levels (HP:0004368)1.88067849
80Epiphyseal dysplasia (HP:0002656)1.87019031
81Hypophosphatemic rickets (HP:0004912)1.85331989
82Photophobia (HP:0000613)1.81599796
83Abnormality of the hepatic vasculature (HP:0006707)1.79675460
84Renovascular hypertension (HP:0100817)1.77727763
85Flattened epiphyses (HP:0003071)1.76773567
86Decreased central vision (HP:0007663)1.75216108
87Gingivitis (HP:0000230)1.73201107
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71911084
89Obstructive lung disease (HP:0006536)1.70952254
90Chronic obstructive pulmonary disease (HP:0006510)1.70952254
91Abnormality of the parathyroid morphology (HP:0011766)1.70541444
92Aplasia/Hypoplasia of the thymus (HP:0010515)1.70301032
93Abnormality of chloride homeostasis (HP:0011422)1.68578577
94Hyperthyroidism (HP:0000836)1.68568350
95Hyponatremia (HP:0002902)1.67496310
96Abnormality of T cell physiology (HP:0011840)1.67243543
97Flat capital femoral epiphysis (HP:0003370)1.67159955
98Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66024004
99Absent epiphyses (HP:0010577)1.66024004
100Alveolar cell carcinoma (HP:0006519)1.65419135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.71131601
2TESK15.42274291
3INSRR4.19292632
4DDR24.11568325
5MAP4K23.45371468
6PLK23.21607508
7BRD43.10378333
8STK382.47050576
9PNCK2.35895793
10PIK3CG2.13268775
11PRKD32.07511628
12AKT31.99360646
13CAMK1G1.83785514
14MAPK151.76388759
15WNK11.71855303
16PDK11.59458995
17PDPK11.55973666
18STK38L1.47221650
19MAP3K111.46900454
20MST1R1.45948187
21RIPK41.41263940
22CDK121.37010242
23PTK2B1.34049302
24TXK1.27540870
25BRAF1.23559804
26CDK71.20796648
27SIK21.19987905
28KSR21.17975561
29DYRK1B1.17439609
30MAP3K20.98418257
31NEK60.95704923
32PRKG20.78268644
33MAP3K90.78158312
34PRKAA20.76474350
35MAP3K10.74167363
36TNK20.68155844
37TYRO30.65886549
38MAP2K20.65696274
39CDK30.65543042
40IKBKB0.64422545
41CAMK10.63961133
42MAP4K10.63022397
43RPS6KA10.62164055
44BLK0.57389836
45PRKG10.57324600
46CDK40.57249306
47MAP3K80.55997424
48KIT0.53345866
49CAMK1D0.50758709
50JAK30.50552695
51MAP3K130.48061774
52TESK20.47663143
53BRSK10.46526357
54CDC70.45845652
55BRSK20.43542975
56RPS6KA20.43318552
57SGK2230.42324055
58SGK4940.42324055
59MAPK10.40586492
60TEC0.38599679
61CAMK40.38028776
62ADRBK20.37980101
63TIE10.36250910
64SYK0.34533110
65GSK3B0.33699715
66HCK0.33303619
67TAOK30.32991724
68SGK10.32775085
69PRKCQ0.32599876
70CDK20.32051607
71CHEK10.31986091
72UHMK10.31292814
73FES0.30840339
74PRKCZ0.30050747
75FRK0.29867278
76CDK10.27783125
77SGK20.27687652
78GRK60.27043863
79PASK0.26885976
80ACVR1B0.26725316
81MAPK80.26692548
82CSF1R0.23802887
83PDK20.23580841
84PRKCG0.22872168
85MAPK110.22799328
86RPS6KL10.22497455
87RPS6KC10.22497455
88GRK70.22295268
89JAK20.22121728
90CHUK0.22014462
91WNK40.21601499
92RPS6KA60.20589382
93CAMKK20.20089251
94ARAF0.19916554
95AKT10.19576494
96ROCK10.19332196
97MARK20.17868902
98BTK0.17760312
99ERN10.17394165
100SGK30.16507275

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.74695014
2Fatty acid biosynthesis_Homo sapiens_hsa000615.67085355
3Olfactory transduction_Homo sapiens_hsa047403.63882509
4Allograft rejection_Homo sapiens_hsa053302.94578839
5Autoimmune thyroid disease_Homo sapiens_hsa053202.78133223
6Graft-versus-host disease_Homo sapiens_hsa053322.77858348
7Antigen processing and presentation_Homo sapiens_hsa046122.73770203
8Type I diabetes mellitus_Homo sapiens_hsa049402.62312041
9Butanoate metabolism_Homo sapiens_hsa006502.41007807
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.83574176
11Viral myocarditis_Homo sapiens_hsa054161.70987188
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.69267156
13Dorso-ventral axis formation_Homo sapiens_hsa043201.67023971
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.60955733
15RNA transport_Homo sapiens_hsa030131.59114583
16Taste transduction_Homo sapiens_hsa047421.52061335
17Influenza A_Homo sapiens_hsa051641.42288172
18Legionellosis_Homo sapiens_hsa051341.24968446
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23787075
20Fatty acid metabolism_Homo sapiens_hsa012121.23214480
21Type II diabetes mellitus_Homo sapiens_hsa049301.22067177
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20844452
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17633468
24Endocytosis_Homo sapiens_hsa041441.15614155
25Inositol phosphate metabolism_Homo sapiens_hsa005621.13032122
26Fatty acid degradation_Homo sapiens_hsa000711.10671374
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06837380
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02338465
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00902388
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00137771
31Herpes simplex infection_Homo sapiens_hsa051680.95173205
32Jak-STAT signaling pathway_Homo sapiens_hsa046300.92030051
33Chemokine signaling pathway_Homo sapiens_hsa040620.91442323
34Primary immunodeficiency_Homo sapiens_hsa053400.88032980
35Adipocytokine signaling pathway_Homo sapiens_hsa049200.87669515
36Leishmaniasis_Homo sapiens_hsa051400.85604941
37NF-kappa B signaling pathway_Homo sapiens_hsa040640.83089611
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80676593
39Phenylalanine metabolism_Homo sapiens_hsa003600.79697947
40Phototransduction_Homo sapiens_hsa047440.79394424
41Osteoclast differentiation_Homo sapiens_hsa043800.77630491
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76435679
43B cell receptor signaling pathway_Homo sapiens_hsa046620.75541590
44Purine metabolism_Homo sapiens_hsa002300.73787831
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72502001
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72240714
47Acute myeloid leukemia_Homo sapiens_hsa052210.71633295
48Calcium signaling pathway_Homo sapiens_hsa040200.71539132
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69247716
50Salivary secretion_Homo sapiens_hsa049700.68830483
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67661562
52cAMP signaling pathway_Homo sapiens_hsa040240.64973502
53Glycerolipid metabolism_Homo sapiens_hsa005610.64661136
54T cell receptor signaling pathway_Homo sapiens_hsa046600.62249049
55Epstein-Barr virus infection_Homo sapiens_hsa051690.62134051
56ABC transporters_Homo sapiens_hsa020100.62116064
57Toxoplasmosis_Homo sapiens_hsa051450.61222410
58Regulation of autophagy_Homo sapiens_hsa041400.60341426
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60215186
60Arginine and proline metabolism_Homo sapiens_hsa003300.60118236
61Selenocompound metabolism_Homo sapiens_hsa004500.59579514
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58231247
63Hematopoietic cell lineage_Homo sapiens_hsa046400.58062627
64Measles_Homo sapiens_hsa051620.57288922
65Morphine addiction_Homo sapiens_hsa050320.56964840
66Viral carcinogenesis_Homo sapiens_hsa052030.54331350
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53449349
68Staphylococcus aureus infection_Homo sapiens_hsa051500.53051005
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.52707149
70Basal transcription factors_Homo sapiens_hsa030220.50664511
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49538334
72TNF signaling pathway_Homo sapiens_hsa046680.45063834
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45006580
74Cardiac muscle contraction_Homo sapiens_hsa042600.42209600
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42063490
76Fat digestion and absorption_Homo sapiens_hsa049750.41634398
77Tuberculosis_Homo sapiens_hsa051520.41307767
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40598695
79Oocyte meiosis_Homo sapiens_hsa041140.39317112
80MAPK signaling pathway_Homo sapiens_hsa040100.39254762
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38517403
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.38214964
83mRNA surveillance pathway_Homo sapiens_hsa030150.37183561
84VEGF signaling pathway_Homo sapiens_hsa043700.36640194
85Malaria_Homo sapiens_hsa051440.35718222
86Protein digestion and absorption_Homo sapiens_hsa049740.35557517
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34436988
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33872954
89Phagosome_Homo sapiens_hsa041450.32753457
90Nitrogen metabolism_Homo sapiens_hsa009100.32597811
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32568632
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32050891
93Synaptic vesicle cycle_Homo sapiens_hsa047210.32047829
94Serotonergic synapse_Homo sapiens_hsa047260.29565380
95PPAR signaling pathway_Homo sapiens_hsa033200.28903618
96RNA polymerase_Homo sapiens_hsa030200.27942390
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27109405
98Estrogen signaling pathway_Homo sapiens_hsa049150.23864470
99Asthma_Homo sapiens_hsa053100.22675640
100Huntingtons disease_Homo sapiens_hsa050160.20421832

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