FAM20A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a protein that is likely secreted and may function in hematopoiesis. A mutation at this locus has been associated with amelogenesis imperfecta and gingival hyperplasia syndrome. Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.79372758
2L-phenylalanine catabolic process (GO:0006559)5.44670206
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.44670206
4alpha-linolenic acid metabolic process (GO:0036109)5.40869690
5L-phenylalanine metabolic process (GO:0006558)5.16709459
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.16709459
7negative regulation of protein activation cascade (GO:2000258)4.93323874
8negative regulation of complement activation (GO:0045916)4.74226992
9complement activation, classical pathway (GO:0006958)4.73797587
10complement activation (GO:0006956)4.62292717
11high-density lipoprotein particle remodeling (GO:0034375)4.61215351
12reverse cholesterol transport (GO:0043691)4.50844146
13regulation of cholesterol esterification (GO:0010872)4.47517382
14protein activation cascade (GO:0072376)4.46542580
15aromatic amino acid family catabolic process (GO:0009074)4.39349952
16peptidyl-glutamic acid carboxylation (GO:0017187)4.31790015
17protein carboxylation (GO:0018214)4.31790015
18regulation of T-helper 1 cell differentiation (GO:0045625)4.28864812
19regulation of T-helper 2 cell differentiation (GO:0045628)4.22334300
20plasma lipoprotein particle remodeling (GO:0034369)4.19854993
21protein-lipid complex remodeling (GO:0034368)4.19854993
22macromolecular complex remodeling (GO:0034367)4.19854993
23sulfur amino acid catabolic process (GO:0000098)4.14016213
24negative regulation of fibrinolysis (GO:0051918)4.11671413
25negative regulation of T-helper cell differentiation (GO:0045623)4.10914589
26negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.10914589
27drug catabolic process (GO:0042737)4.10640015
28complement activation, alternative pathway (GO:0006957)4.08259313
29low-density lipoprotein particle remodeling (GO:0034374)4.01248212
30regulation of protein activation cascade (GO:2000257)3.99074380
31regulation of triglyceride catabolic process (GO:0010896)3.94969418
32regulation of fibrinolysis (GO:0051917)3.90868377
33epoxygenase P450 pathway (GO:0019373)3.85811631
34omega-hydroxylase P450 pathway (GO:0097267)3.83268580
35blood coagulation, intrinsic pathway (GO:0007597)3.82602784
36phospholipid efflux (GO:0033700)3.81790206
37regulation of complement activation (GO:0030449)3.81257494
38urea cycle (GO:0000050)3.76213711
39urea metabolic process (GO:0019627)3.76213711
40positive regulation of triglyceride metabolic process (GO:0090208)3.72388284
41bile acid biosynthetic process (GO:0006699)3.70628540
42positive regulation of triglyceride biosynthetic process (GO:0010867)3.69287030
43negative regulation of blood coagulation (GO:0030195)3.69146679
44negative regulation of hemostasis (GO:1900047)3.69146679
45negative regulation of humoral immune response (GO:0002921)3.68681991
46regulation of cholesterol biosynthetic process (GO:0045540)3.67592321
47exogenous drug catabolic process (GO:0042738)3.66450079
48regulation of cholesterol homeostasis (GO:2000188)3.65530546
49regulation of humoral immune response (GO:0002920)3.63986572
50plasma lipoprotein particle assembly (GO:0034377)3.61914355
51acute-phase response (GO:0006953)3.55526071
52positive regulation of fatty acid beta-oxidation (GO:0032000)3.55359167
53cysteine metabolic process (GO:0006534)3.53884653
54indolalkylamine catabolic process (GO:0046218)3.53809346
55tryptophan catabolic process (GO:0006569)3.53809346
56indole-containing compound catabolic process (GO:0042436)3.53809346
57positive regulation of fatty acid biosynthetic process (GO:0045723)3.52858169
58glyoxylate metabolic process (GO:0046487)3.52126165
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.51626628
60kynurenine metabolic process (GO:0070189)3.51339877
61cellular modified amino acid catabolic process (GO:0042219)3.49286516
62negative regulation of sterol transport (GO:0032372)3.47523607
63negative regulation of cholesterol transport (GO:0032375)3.47523607
64Golgi transport vesicle coating (GO:0048200)3.46784093
65COPI coating of Golgi vesicle (GO:0048205)3.46784093
66linoleic acid metabolic process (GO:0043651)3.46165299
67plasma lipoprotein particle organization (GO:0071827)3.44740123
68plasma lipoprotein particle clearance (GO:0034381)3.43722074
69triglyceride homeostasis (GO:0070328)3.42142601
70acylglycerol homeostasis (GO:0055090)3.42142601
71negative regulation of coagulation (GO:0050819)3.42057579
72opsonization (GO:0008228)3.41310650
73tryptophan metabolic process (GO:0006568)3.41270953
74nitrogen cycle metabolic process (GO:0071941)3.40497776
75regulation of triglyceride biosynthetic process (GO:0010866)3.36478857
76amino-acid betaine metabolic process (GO:0006577)3.35010478
77homocysteine metabolic process (GO:0050667)3.30896084
78very-low-density lipoprotein particle assembly (GO:0034379)3.29669939
79regulation of triglyceride metabolic process (GO:0090207)3.28245265
80tyrosine metabolic process (GO:0006570)3.28077719
81protein-lipid complex assembly (GO:0065005)3.27461827
82lipoprotein metabolic process (GO:0042157)3.27406964
83detection of molecule of bacterial origin (GO:0032490)3.26543368
84protein-lipid complex subunit organization (GO:0071825)3.25843444
85cholesterol efflux (GO:0033344)3.25723359
86negative regulation of wound healing (GO:0061045)3.25570412
87COPII vesicle coating (GO:0048208)3.25327424
88alanine transport (GO:0032328)3.24299973
89serine family amino acid catabolic process (GO:0009071)3.21649883
90negative regulation of type 2 immune response (GO:0002829)3.21466469
91detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.21173139
92bile acid metabolic process (GO:0008206)3.21163150
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18720075
94positive regulation of lipid catabolic process (GO:0050996)3.16867097
95glutamate metabolic process (GO:0006536)3.15858318
96regulation of plasminogen activation (GO:0010755)3.14355619
97cellular ketone body metabolic process (GO:0046950)3.14276969
98positive regulation of fatty acid oxidation (GO:0046321)3.13602500
99lysine metabolic process (GO:0006553)3.12947478
100lysine catabolic process (GO:0006554)3.12947478
101regulation of cholesterol metabolic process (GO:0090181)3.12751718
102alpha-amino acid catabolic process (GO:1901606)3.08724745
103positive regulation of fatty acid metabolic process (GO:0045923)3.07490889
104aromatic amino acid family metabolic process (GO:0009072)3.06922844
105fatty-acyl-CoA biosynthetic process (GO:0046949)3.06830574
106intestinal cholesterol absorption (GO:0030299)3.04527025
107coenzyme catabolic process (GO:0009109)3.04500740
108regulation of apoptotic cell clearance (GO:2000425)3.03386245
109fibrinolysis (GO:0042730)3.01120710
110dicarboxylic acid biosynthetic process (GO:0043650)3.00138123
111short-chain fatty acid metabolic process (GO:0046459)2.99448776
112cellular amino acid catabolic process (GO:0009063)2.95979685
113ethanol oxidation (GO:0006069)2.95151112
114cAMP biosynthetic process (GO:0006171)2.94618922
115thioester biosynthetic process (GO:0035384)2.93710759
116acyl-CoA biosynthetic process (GO:0071616)2.93710759
117positive regulation of blood coagulation (GO:0030194)2.93646286
118positive regulation of hemostasis (GO:1900048)2.93646286
119phospholipid homeostasis (GO:0055091)2.93575479
120hyaluronan catabolic process (GO:0030214)2.93384627
121positive regulation of triglyceride lipase activity (GO:0061365)2.93101375
122positive regulation of lipoprotein lipase activity (GO:0051006)2.93101375
123drug transmembrane transport (GO:0006855)2.92162682
124long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.91647467
125positive regulation of steroid metabolic process (GO:0045940)2.90219022
126regulation of acute inflammatory response (GO:0002673)2.89659693
127regulation of fatty acid beta-oxidation (GO:0031998)2.86932948
128acute inflammatory response (GO:0002526)2.85722418
129cellular glucuronidation (GO:0052695)2.85284466
130acetyl-CoA metabolic process (GO:0006084)2.85236231
131positive regulation of coagulation (GO:0050820)2.85123850
132negative regulation of platelet activation (GO:0010544)2.83729948
1334-hydroxyproline metabolic process (GO:0019471)2.83579705
134positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82664270
135negative regulation of lipase activity (GO:0060192)2.79834969
136negative regulation of alpha-beta T cell differentiation (GO:0046639)2.73878743
137hyaluronan metabolic process (GO:0030212)2.69499418
138drug metabolic process (GO:0017144)2.60929733
139positive regulation of protein sumoylation (GO:0033235)2.57662633
140regulation of macrophage chemotaxis (GO:0010758)2.53886592
141fat-soluble vitamin biosynthetic process (GO:0042362)2.50918775
142drug transport (GO:0015893)2.50387325
143positive regulation of cholesterol efflux (GO:0010875)2.47737841
144protein K11-linked deubiquitination (GO:0035871)2.47115117
145surfactant homeostasis (GO:0043129)2.45480930
146regulation of blood coagulation (GO:0030193)2.44014527
147regulation of hemostasis (GO:1900046)2.44014527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.33702077
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.83881866
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.95334078
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.77215315
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.90889847
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.88950985
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67553161
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15045887
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.03118301
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.00908140
11* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.41275375
12CLOCK_20551151_ChIP-Seq_293T_Human2.29925635
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.18598808
14* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14431284
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06864423
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.95928272
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95426014
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94073328
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.88391536
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87024952
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80946423
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78569942
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.76780145
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.57369083
25SMAD3_21741376_ChIP-Seq_HESCs_Human1.52624235
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52093390
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.50331935
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.47782211
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.46249835
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45514907
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44706929
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35825614
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32906061
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31899655
35VDR_22108803_ChIP-Seq_LS180_Human1.26499215
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26418291
37VDR_24787735_ChIP-Seq_THP-1_Human1.24657388
38SMAD4_21741376_ChIP-Seq_HESCs_Human1.24309699
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23810502
40HTT_18923047_ChIP-ChIP_STHdh_Human1.23322967
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20966541
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18950179
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15588882
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15518353
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15518353
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.15495759
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15332761
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13226910
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11758258
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11670998
51* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10774350
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.06955880
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06404831
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04488961
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04134658
56LXR_22292898_ChIP-Seq_THP-1_Human1.03716253
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03429408
58BCAT_22108803_ChIP-Seq_LS180_Human1.02230399
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01619971
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00995064
61GBX2_23144817_ChIP-Seq_PC3_Human1.00643492
62* SMAD3_21741376_ChIP-Seq_EPCs_Human0.99762428
63* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99620320
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99249291
65CJUN_26792858_Chip-Seq_BT549_Human0.99123151
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98163443
67ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96831026
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96495370
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96345197
70TBX20_22328084_ChIP-Seq_HEART_Mouse0.95490418
71TBX20_22080862_ChIP-Seq_HEART_Mouse0.95490418
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95005032
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95005032
74EZH2_27294783_Chip-Seq_NPCs_Mouse0.94798973
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94191537
76GATA1_22025678_ChIP-Seq_K562_Human0.93930605
77TP63_17297297_ChIP-ChIP_HaCaT_Human0.93040693
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92393418
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92281085
80* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91915885
81GATA4_25053715_ChIP-Seq_YYC3_Human0.90561390
82SOX2_20726797_ChIP-Seq_SW620_Human0.90520849
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90262217
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90203490
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89686649
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89686649
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89686649
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89482952
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88460878
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88140169
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87988919
92AR_21572438_ChIP-Seq_LNCaP_Human0.87411838
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.86337343
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.85112297
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84225436
96CDX2_22108803_ChIP-Seq_LS180_Human0.84039559
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.83882697
98MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83598938
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82865405
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.82070566
101EP300_21415370_ChIP-Seq_HL-1_Mouse0.81845555
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81801624
103* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81443239
104NFE2_27457419_Chip-Seq_LIVER_Mouse0.80744732
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80304433
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80297500
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79973993
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79600075
109SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78856082
110GATA1_19941826_ChIP-Seq_K562_Human0.78704083
111EED_16625203_ChIP-ChIP_MESCs_Mouse0.78255350
112AHR_22903824_ChIP-Seq_MCF-7_Human0.77917913
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77689016
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77355570
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76852296
116RACK7_27058665_Chip-Seq_MCF-7_Human0.75026028
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74586324
118* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73373600
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.72666252
120* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72580266
121* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72476658
122* TP53_18474530_ChIP-ChIP_U2OS_Human0.70085317
123RXR_22108803_ChIP-Seq_LS180_Human0.68743482
124TP63_23658742_ChIP-Seq_EP156T_Human0.68228947
125* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66880836
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65707404
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64463757
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.63941100
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.63819350
130DROSHA_22980978_ChIP-Seq_HELA_Human0.63725069
131* MYC_27129775_Chip-Seq_CORNEA_Mouse0.63170157
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63041508
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62926148
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.62171237
135GATA2_19941826_ChIP-Seq_K562_Human0.61364574
136SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.61305838
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.61044707
138P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60953047
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60909982
140* RARA_24833708_ChIP-Seq_LIVER_Mouse0.59342412
141ERG_20517297_ChIP-Seq_VCAP_Human0.59060232
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58645093
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.57741262
144* TP53_16413492_ChIP-PET_HCT116_Human0.57330769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.03038729
2MP0005360_urolithiasis5.48800572
3MP0005365_abnormal_bile_salt4.85764407
4MP0005085_abnormal_gallbladder_physiolo4.20128752
5MP0009840_abnormal_foam_cell3.30023881
6MP0003195_calcinosis3.13556135
7MP0006054_spinal_hemorrhage3.10620511
8MP0008438_abnormal_cutaneous_collagen3.03933403
9MP0010329_abnormal_lipoprotein_level3.02026988
10MP0008875_abnormal_xenobiotic_pharmacok2.98187677
11MP0003252_abnormal_bile_duct2.95010442
12MP0003806_abnormal_nucleotide_metabolis2.78342497
13MP0003705_abnormal_hypodermis_morpholog2.65624316
14MP0005332_abnormal_amino_acid2.49913430
15MP0001881_abnormal_mammary_gland2.37664811
16MP0005083_abnormal_biliary_tract2.35750424
17MP0009384_cardiac_valve_regurgitation2.34139834
18MP0008004_abnormal_stomach_pH2.33382010
19MP0002254_reproductive_system_inflammat2.27529821
20MP0009780_abnormal_chondrocyte_physiolo2.10772078
21MP0008961_abnormal_basal_metabolism2.06514773
22MP0004019_abnormal_vitamin_homeostasis2.03359333
23MP0001666_abnormal_nutrient_absorption2.02503250
24MP0002118_abnormal_lipid_homeostasis1.91534527
25MP0003303_peritoneal_inflammation1.91478326
26MP0003279_aneurysm1.87483067
27MP0002837_dystrophic_cardiac_calcinosis1.84716394
28MP0000013_abnormal_adipose_tissue1.80995780
29MP0003011_delayed_dark_adaptation1.80894807
30MP0005275_abnormal_skin_tensile1.78837152
31MP0000609_abnormal_liver_physiology1.69201586
32MP0003690_abnormal_glial_cell1.56989369
33MP0005503_abnormal_tendon_morphology1.55272037
34MP0003300_gastrointestinal_ulcer1.53332029
35MP0005670_abnormal_white_adipose1.48593370
36MP0006082_CNS_inflammation1.43856948
37MP0001533_abnormal_skeleton_physiology1.42318622
38MP0002998_abnormal_bone_remodeling1.41464551
39MP0002909_abnormal_adrenal_gland1.38763004
40MP0005220_abnormal_exocrine_pancreas1.36113285
41MP0002138_abnormal_hepatobiliary_system1.32222052
42MP0004883_abnormal_blood_vessel1.29927375
43MP0009643_abnormal_urine_homeostasis1.27870731
44MP0009785_altered_susceptibility_to1.27249901
45MP0005319_abnormal_enzyme/_coenzyme1.26586607
46MP0003868_abnormal_feces_composition1.25381457
47MP0001915_intracranial_hemorrhage1.25262365
48MP0003172_abnormal_lysosome_physiology1.23747041
49MP0004272_abnormal_basement_membrane1.22972939
50MP0005584_abnormal_enzyme/coenzyme_acti1.22372359
51MP0002419_abnormal_innate_immunity1.21573235
52MP0002933_joint_inflammation1.19778412
53MP0002078_abnormal_glucose_homeostasis1.17809864
54MP0003436_decreased_susceptibility_to1.17392291
55MP0001790_abnormal_immune_system1.16654336
56MP0005387_immune_system_phenotype1.16654336
57MP0008469_abnormal_protein_level1.16350673
58MP0003329_amyloid_beta_deposits1.15352877
59MP0005084_abnormal_gallbladder_morpholo1.13457120
60MP0002168_other_aberrant_phenotype1.11774928
61MP0000604_amyloidosis1.11033214
62MP0003191_abnormal_cellular_cholesterol1.09616247
63MP0004510_myositis1.08060503
64MP0000767_abnormal_smooth_muscle1.07339426
65MP0004130_abnormal_muscle_cell1.06724109
66MP0001542_abnormal_bone_strength1.06326877
67MP0010368_abnormal_lymphatic_system1.05005394
68MP0005379_endocrine/exocrine_gland_phen1.04055026
69MP0001944_abnormal_pancreas_morphology1.02965371
70MP0005636_abnormal_mineral_homeostasis1.02405158
71MP0002148_abnormal_hypersensitivity_rea1.02340564
72MP0003091_abnormal_cell_migration0.98665470
73MP0000343_altered_response_to0.96926732
74MP0003183_abnormal_peptide_metabolism0.96300633
75MP0000639_abnormal_adrenal_gland0.94320831
76MP0000249_abnormal_blood_vessel0.94163835
77MP0004043_abnormal_pH_regulation0.94027202
78MP0005451_abnormal_body_composition0.93364393
79MP0003045_fibrosis0.92055691
80MP0002971_abnormal_brown_adipose0.90857363
81MP0002295_abnormal_pulmonary_circulatio0.88377830
82MP0005025_abnormal_response_to0.86860601
83MP0002060_abnormal_skin_morphology0.86066275
84MP0001756_abnormal_urination0.86000751
85MP0001851_eye_inflammation0.84969493
86MP0005390_skeleton_phenotype0.84597589
87MP0002877_abnormal_melanocyte_morpholog0.81943206
88MP0005167_abnormal_blood-brain_barrier0.81765313
89MP0001835_abnormal_antigen_presentation0.81594777
90MP0003075_altered_response_to0.81074704
91MP0002693_abnormal_pancreas_physiology0.80946776
92MP0000003_abnormal_adipose_tissue0.80937194
93MP0001764_abnormal_homeostasis0.80234456
94MP0001958_emphysema0.80053069
95MP0003724_increased_susceptibility_to0.79808413
96MP0001661_extended_life_span0.77609111
97MP0002108_abnormal_muscle_morphology0.77213573
98MP0002896_abnormal_bone_mineralization0.76423904
99MP0004133_heterotaxia0.76376261
100MP0001845_abnormal_inflammatory_respons0.76374332
101MP0005334_abnormal_fat_pad0.75745832
102MP0009642_abnormal_blood_homeostasis0.75595663
103MP0000598_abnormal_liver_morphology0.74351976
104MP0002405_respiratory_system_inflammati0.74118766
105MP0005023_abnormal_wound_healing0.74101857
106MP0000920_abnormal_myelination0.73250318
107MP0004782_abnormal_surfactant_physiolog0.73157141
108MP0009764_decreased_sensitivity_to0.73040592
109MP0001243_abnormal_dermal_layer0.72912964
110MP0003186_abnormal_redox_activity0.70419679
111MP0002876_abnormal_thyroid_physiology0.70254092
112MP0005508_abnormal_skeleton_morphology0.70152980
113MP0002128_abnormal_blood_circulation0.69614760
114MP0005647_abnormal_sex_gland0.69185083
115MP0005257_abnormal_intraocular_pressure0.68613225
116MP0005375_adipose_tissue_phenotype0.68004737
117MP0000685_abnormal_immune_system0.67817154
118MP0005058_abnormal_lysosome_morphology0.67227878
119MP0005388_respiratory_system_phenotype0.67053437
120MP0002133_abnormal_respiratory_system0.67053437
121MP0003950_abnormal_plasma_membrane0.66904350
122MP0005666_abnormal_adipose_tissue0.66766003
123MP0005376_homeostasis/metabolism_phenot0.66630257
124MP0003953_abnormal_hormone_level0.66574509
125MP0002136_abnormal_kidney_physiology0.66353391
126MP0005395_other_phenotype0.66319190
127MP0001765_abnormal_ion_homeostasis0.65665092
128MP0009763_increased_sensitivity_to0.64459301
129MP0000678_abnormal_parathyroid_gland0.64002348
130MP0005535_abnormal_body_temperature0.63939185
131MP0005166_decreased_susceptibility_to0.63661836
132MP0005448_abnormal_energy_balance0.62684167
133MP0003638_abnormal_response/metabolism_0.62347809
134MP0005595_abnormal_vascular_smooth0.61694064
135MP0001986_abnormal_taste_sensitivity0.60514509
136MP0004264_abnormal_extraembryonic_tissu0.59685986
137MP0005646_abnormal_pituitary_gland0.59232168
138MP0004858_abnormal_nervous_system0.57692843
139MP0003656_abnormal_erythrocyte_physiolo0.56357206
140MP0003566_abnormal_cell_adhesion0.56042091
141MP0000230_abnormal_systemic_arterial0.54926135
142MP0005408_hypopigmentation0.54601608
143MP0002928_abnormal_bile_duct0.52994199
144MP0000163_abnormal_cartilage_morphology0.51950252
145MP0004885_abnormal_endolymph0.51546828
146MP0001502_abnormal_circadian_rhythm0.50458578
147MP0005164_abnormal_response_to0.49622755
148MP0005165_increased_susceptibility_to0.49572506

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.46116807
2Xanthomatosis (HP:0000991)5.41872244
3Deep venous thrombosis (HP:0002625)5.31487141
4Hypoglycemic coma (HP:0001325)5.01976681
5Intrahepatic cholestasis (HP:0001406)4.84763233
6Hyperlipoproteinemia (HP:0010980)4.83102676
7Prolonged partial thromboplastin time (HP:0003645)4.49706954
8Hypoglycemic seizures (HP:0002173)4.48017210
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.42093503
10Hypoalphalipoproteinemia (HP:0003233)4.24339611
11Hyperinsulinemic hypoglycemia (HP:0000825)4.11409622
12Complement deficiency (HP:0004431)4.05639603
13Ketoacidosis (HP:0001993)4.03127024
14Ketosis (HP:0001946)3.92282270
15Recurrent gram-negative bacterial infections (HP:0005420)3.77503183
16Hypolipoproteinemia (HP:0010981)3.75930906
17Hypobetalipoproteinemia (HP:0003563)3.62482138
18Symptomatic seizures (HP:0011145)3.62292857
19Abnormality of the common coagulation pathway (HP:0010990)3.59454910
20Hyperglycinuria (HP:0003108)3.33333810
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.29562304
22Abnormality of the intrinsic pathway (HP:0010989)3.28729033
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.15889519
24Hyperglycinemia (HP:0002154)3.15301586
25Hyperammonemia (HP:0001987)3.12773321
26Back pain (HP:0003418)3.12297785
27Late onset (HP:0003584)3.11678843
28Conjugated hyperbilirubinemia (HP:0002908)3.11078788
29Protrusio acetabuli (HP:0003179)3.10913248
30Abnormality of complement system (HP:0005339)3.09663500
31Epidermoid cyst (HP:0200040)3.09472248
32Abnormality of glycine metabolism (HP:0010895)3.00850773
33Abnormality of serine family amino acid metabolism (HP:0010894)3.00850773
34Hyperglycemia (HP:0003074)2.97042968
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.94590585
36Joint hemorrhage (HP:0005261)2.94221686
37Abnormality of purine metabolism (HP:0004352)2.86135933
38Interstitial pulmonary disease (HP:0006530)2.80935076
39Purpura (HP:0000979)2.79258932
40Skin nodule (HP:0200036)2.75066156
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74998064
42Abnormality of liposaccharide metabolism (HP:0010968)2.72414806
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.72414806
44Abnormality of glycolipid metabolism (HP:0010969)2.72414806
45Gingival bleeding (HP:0000225)2.72185952
46Orchitis (HP:0100796)2.71584880
47Premature rupture of membranes (HP:0001788)2.69428263
48Spontaneous abortion (HP:0005268)2.67893420
49Mitral stenosis (HP:0001718)2.67777064
50Urinary glycosaminoglycan excretion (HP:0003541)2.66873860
51Mucopolysacchariduria (HP:0008155)2.66873860
52Fat malabsorption (HP:0002630)2.65050946
53Myocardial infarction (HP:0001658)2.64860636
54Osteomalacia (HP:0002749)2.61855028
55Hypercholesterolemia (HP:0003124)2.59258192
56Gout (HP:0001997)2.56015151
57Optic neuritis (HP:0100653)2.53455552
58Retrobulbar optic neuritis (HP:0100654)2.53455552
59Systemic lupus erythematosus (HP:0002725)2.53137942
60Turricephaly (HP:0000262)2.52449075
61Abnormality of methionine metabolism (HP:0010901)2.51020125
62Cervical subluxation (HP:0003308)2.49862727
63Aortic aneurysm (HP:0004942)2.46815893
64Abnormality of nucleobase metabolism (HP:0010932)2.45326895
65Vacuolated lymphocytes (HP:0001922)2.45020064
66Abnormality of polysaccharide metabolism (HP:0011012)2.44522278
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44522278
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44522278
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43217562
70Abnormality of endocrine pancreas physiology (HP:0012093)2.39571891
71Abnormality of the pancreatic islet cells (HP:0006476)2.39571891
72Cardiovascular calcification (HP:0011915)2.35894417
73Abnormality of fatty-acid metabolism (HP:0004359)2.35478916
74Hydroxyprolinuria (HP:0003080)2.31882082
75Abnormality of proline metabolism (HP:0010907)2.31882082
76Biconcave vertebral bodies (HP:0004586)2.30420352
77Hemorrhage of the eye (HP:0011885)2.29927985
78Striae distensae (HP:0001065)2.27560073
79Cerebral aneurysm (HP:0004944)2.26984509
80Peritonitis (HP:0002586)2.26621202
81Vascular tortuosity (HP:0004948)2.26144001
82Soft skin (HP:0000977)2.25383949
83Amyloidosis (HP:0011034)2.21543179
84Vascular calcification (HP:0004934)2.20334333
85Myositis (HP:0100614)2.18033864
86Ectopia lentis (HP:0001083)2.17879456
87Hyperbilirubinemia (HP:0002904)2.16738186
88Enlarged kidneys (HP:0000105)2.16667581
89Neurofibrillary tangles (HP:0002185)2.16212643
90Retinal atrophy (HP:0001105)2.15970911
91Abnormality of pyrimidine metabolism (HP:0004353)2.14130181
92Protuberant abdomen (HP:0001538)2.05868522
93Broad metatarsal (HP:0001783)2.05289533
94Spontaneous hematomas (HP:0007420)2.04256039
95Pulmonary embolism (HP:0002204)2.01303968
96Tetraparesis (HP:0002273)2.00544680
97Irritability (HP:0000737)2.00523128
98Hepatocellular carcinoma (HP:0001402)1.96775990
99Glomerulonephritis (HP:0000099)1.96229206
100Insulin resistance (HP:0000855)1.95499001
101Thrombophlebitis (HP:0004418)1.94970306
102Menorrhagia (HP:0000132)1.93846515
103Insulin-resistant diabetes mellitus (HP:0000831)1.92634092
104Keratoconjunctivitis sicca (HP:0001097)1.91304879
105Sensorimotor neuropathy (HP:0007141)1.90472349
106Arterial tortuosity (HP:0005116)1.88827835
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88679625
108Nephritis (HP:0000123)1.87749218
109Follicular hyperkeratosis (HP:0007502)1.87579815
110Metabolic acidosis (HP:0001942)1.85320472
111Generalized aminoaciduria (HP:0002909)1.84840161
112Dysostosis multiplex (HP:0000943)1.82814555
113Hematochezia (HP:0002573)1.82522581
114Blue sclerae (HP:0000592)1.81204685
115Atrophic scars (HP:0001075)1.80393608
116Infantile muscular hypotonia (HP:0008947)1.80379787
117Pancreatic islet-cell hyperplasia (HP:0004510)1.79509122
118Gangrene (HP:0100758)1.79284962
119Aortic dissection (HP:0002647)1.78905791
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78739560
121Dicarboxylic aciduria (HP:0003215)1.78739560
122Epistaxis (HP:0000421)1.77233557
123Delayed CNS myelination (HP:0002188)1.77183475
124Beaking of vertebral bodies (HP:0004568)1.76576479
125Pseudobulbar signs (HP:0002200)1.75991967
126Keratoconjunctivitis (HP:0001096)1.75037147
127Abnormality of serum amino acid levels (HP:0003112)1.74526454
128Rickets (HP:0002748)1.73859386
129Abnormality of transition element cation homeostasis (HP:0011030)1.73803423
130Cerebral inclusion bodies (HP:0100314)1.71347206
131Abnormality of macrophages (HP:0004311)1.70101422
132Pancreatitis (HP:0001733)1.69169851
133Esophageal varix (HP:0002040)1.68861633
134Aplasia of the phalanges of the hand (HP:0009802)1.68798690
135Aplasia involving bones of the extremities (HP:0009825)1.68798690
136Joint stiffness (HP:0001387)1.68638093
137Recurrent abscess formation (HP:0002722)1.67402624
138Vertebral compression fractures (HP:0002953)1.66562713
139Aneurysm (HP:0002617)1.65729072
140Abnormal delivery (HP:0001787)1.64745386
141Abnormality of the vasculature of the conjunctiva (HP:0008054)1.64694662
142Mesangial abnormality (HP:0001966)1.63253181
143Chondrocalcinosis (HP:0000934)1.62927959
144Gingivitis (HP:0000230)1.62770641
145Steatorrhea (HP:0002570)1.62508810
146Ovoid vertebral bodies (HP:0003300)1.61636589
147Arthropathy (HP:0003040)1.58946836
148Asymmetric septal hypertrophy (HP:0001670)1.57394937
149Abnormality of Sharpey fibers (HP:0100685)1.56797268
150Loss of speech (HP:0002371)1.56389132
151Conjunctival telangiectasia (HP:0000524)1.55818553
152Autoimmune thrombocytopenia (HP:0001973)1.55230002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.69129098
2ERN14.46590618
3INSRR4.31141245
4BLK4.07953623
5NTRK23.95886488
6TRIB33.90326722
7BCKDK2.80559436
8MAPK152.61379116
9FGFR42.38008941
10PIK3CG2.25100853
11PRKD32.13710393
12CAMK1D2.07060770
13PTK61.98064289
14KIT1.96388101
15RIPK11.89012606
16FRK1.88171865
17CAMK1G1.79767814
18EPHB11.79134479
19EPHA31.73617311
20STK31.68315659
21AKT31.63849340
22MAP4K11.62380942
23TAOK31.60400797
24IRAK31.58122634
25PKN21.56736914
26GRK71.55473980
27WNK31.54886214
28PDGFRA1.47545247
29ACVR1B1.47460982
30PDK21.40184495
31ADRBK21.34196861
32LMTK21.27796768
33MYLK1.27370161
34WNK41.26603690
35PTK21.25849812
36TBK11.25691599
37MAP3K31.24682070
38IKBKE1.22707765
39MAP3K61.18334887
40MST1R1.16804017
41CCNB11.12425539
42RIPK41.11202619
43GRK11.09188668
44MET1.07921768
45JAK31.06180465
46MAP3K141.00851555
47FLT30.97370292
48MATK0.97327782
49ERBB40.97003304
50ZAP700.96560940
51PRKAA20.95972692
52JAK10.95701234
53NTRK10.94353362
54PIK3CA0.93734193
55CHUK0.93014737
56PAK30.92707987
57FGR0.91967342
58DDR20.90825759
59MAPKAPK30.90500475
60RET0.90166311
61ERBB20.86568024
62PDK40.85903752
63PDK30.85903752
64MAP3K70.85570133
65BMX0.84128906
66MAPK120.83253574
67LATS10.81722966
68HIPK20.81163358
69DAPK20.80454970
70ABL20.80235176
71MAP3K20.79444549
72MAP2K40.76637968
73FGFR10.75790056
74MAPK110.75110189
75MAPK70.74829352
76IGF1R0.74299960
77MAP2K20.73955817
78FER0.73475954
79NLK0.72806804
80PHKG20.72645479
81PHKG10.72645479
82SGK30.70746977
83JAK20.66999994
84IKBKB0.64364671
85NEK90.64244036
86ABL10.63945390
87CSK0.63664307
88FGFR30.61582762
89PDGFRB0.60853308
90CDC42BPA0.60155397
91MTOR0.60055762
92SGK20.58432717
93PRKCH0.56416019
94LYN0.56362365
95IRAK10.53454619
96IRAK40.53438748
97MAP3K10.52590713
98TRPM70.51686456
99MAP2K10.51335614
100STK38L0.50690148
101PRKAA10.50049103
102BMPR20.48455028
103PRKCG0.48170554
104LATS20.47857829
105GSK3A0.47792201
106PRKD10.46651136
107SRC0.46534097
108MAPK40.45915694
109MARK20.45242762
110TYK20.45126700
111PINK10.45104911
112DYRK1B0.45077393
113TGFBR20.44641606
114PRKACG0.44061971
115INSR0.43907414
116TIE10.43727281
117CAMKK20.43462016
118SGK2230.43191945
119SGK4940.43191945
120RPS6KA20.43186011
121EGFR0.42166332
122MAP2K30.41567836
123ADRBK10.41554072
124PRKCE0.40325194
125PRKG10.39545332
126PTK2B0.39048816
127EEF2K0.38948112
128CAMK2G0.38940970
129HCK0.38845508
130CSF1R0.38621164
131EPHA40.38348996
132FGFR20.37753799
133MUSK0.37069753
134SYK0.36435610
135CAMKK10.36157558
136ROCK10.35927662
137STK380.35655215
138KDR0.35362088
139EPHB20.34775502
140MELK0.34713399
141PAK20.33614593
142PDPK10.33082320
143LRRK20.33069699

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.39283026
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.26402508
3Caffeine metabolism_Homo sapiens_hsa002322.84160587
4Fatty acid biosynthesis_Homo sapiens_hsa000612.82657727
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74240808
6Fatty acid degradation_Homo sapiens_hsa000712.70841523
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.54714826
8Complement and coagulation cascades_Homo sapiens_hsa046102.41127606
9Fatty acid metabolism_Homo sapiens_hsa012122.41031818
10Arginine biosynthesis_Homo sapiens_hsa002202.40763271
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39350266
12Tryptophan metabolism_Homo sapiens_hsa003802.30227074
13PPAR signaling pathway_Homo sapiens_hsa033202.18871549
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08428375
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07351162
16Sulfur metabolism_Homo sapiens_hsa009202.03524207
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92303770
18Peroxisome_Homo sapiens_hsa041461.85866668
19Propanoate metabolism_Homo sapiens_hsa006401.84703402
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84585101
21Butanoate metabolism_Homo sapiens_hsa006501.72226958
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68790817
23Pertussis_Homo sapiens_hsa051331.66694190
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60290533
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57479110
26Bile secretion_Homo sapiens_hsa049761.52735268
27Histidine metabolism_Homo sapiens_hsa003401.49398812
28Staphylococcus aureus infection_Homo sapiens_hsa051501.42962790
29Chemical carcinogenesis_Homo sapiens_hsa052041.37972375
30Selenocompound metabolism_Homo sapiens_hsa004501.34575695
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28742990
32Pyruvate metabolism_Homo sapiens_hsa006201.28636164
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.28611508
34Starch and sucrose metabolism_Homo sapiens_hsa005001.25400740
35Arachidonic acid metabolism_Homo sapiens_hsa005901.24585413
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23989786
37Phenylalanine metabolism_Homo sapiens_hsa003601.20261240
38Galactose metabolism_Homo sapiens_hsa000521.17946659
39Fatty acid elongation_Homo sapiens_hsa000621.15990918
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15033801
41beta-Alanine metabolism_Homo sapiens_hsa004101.14502147
42Fat digestion and absorption_Homo sapiens_hsa049751.13280457
43ABC transporters_Homo sapiens_hsa020101.11989459
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.11849550
45Steroid biosynthesis_Homo sapiens_hsa001001.10087431
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08346955
47Tyrosine metabolism_Homo sapiens_hsa003501.07766182
48Folate biosynthesis_Homo sapiens_hsa007901.05943996
49Ovarian steroidogenesis_Homo sapiens_hsa049131.04863114
50Retinol metabolism_Homo sapiens_hsa008301.02738149
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97267980
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.93608548
53Arginine and proline metabolism_Homo sapiens_hsa003300.92699087
54Vitamin digestion and absorption_Homo sapiens_hsa049770.92136827
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88877643
56Protein export_Homo sapiens_hsa030600.85800559
57Carbon metabolism_Homo sapiens_hsa012000.83843631
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80770233
59Osteoclast differentiation_Homo sapiens_hsa043800.79873447
60Lysine degradation_Homo sapiens_hsa003100.77942548
61Biosynthesis of amino acids_Homo sapiens_hsa012300.77197700
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76476751
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75317913
64Sulfur relay system_Homo sapiens_hsa041220.72514709
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71569313
66Insulin resistance_Homo sapiens_hsa049310.70879985
67Olfactory transduction_Homo sapiens_hsa047400.70658130
68Leishmaniasis_Homo sapiens_hsa051400.69936855
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69418605
70Rheumatoid arthritis_Homo sapiens_hsa053230.67506830
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.67094673
72African trypanosomiasis_Homo sapiens_hsa051430.65566987
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.65464884
74Glycerolipid metabolism_Homo sapiens_hsa005610.65315455
75Tuberculosis_Homo sapiens_hsa051520.64456423
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64383947
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64101438
78Phagosome_Homo sapiens_hsa041450.63178279
79Insulin secretion_Homo sapiens_hsa049110.62716701
80Glucagon signaling pathway_Homo sapiens_hsa049220.61641402
81Other glycan degradation_Homo sapiens_hsa005110.61477308
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60427559
83Prion diseases_Homo sapiens_hsa050200.60258926
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59505827
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.59291972
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.58630897
87Ether lipid metabolism_Homo sapiens_hsa005650.57202162
88TNF signaling pathway_Homo sapiens_hsa046680.56368370
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55391778
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52955400
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51462279
92Dorso-ventral axis formation_Homo sapiens_hsa043200.50735026
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50607820
94Platelet activation_Homo sapiens_hsa046110.49582326
95Sphingolipid metabolism_Homo sapiens_hsa006000.48666242
96Pentose phosphate pathway_Homo sapiens_hsa000300.45356076
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.43180810
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40894282
99Lysosome_Homo sapiens_hsa041420.39770136
100Glutathione metabolism_Homo sapiens_hsa004800.38123043
101Toxoplasmosis_Homo sapiens_hsa051450.36957986
102Vitamin B6 metabolism_Homo sapiens_hsa007500.36898864
103Fructose and mannose metabolism_Homo sapiens_hsa000510.36805252
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35983580
105Asthma_Homo sapiens_hsa053100.34578059
106Thyroid hormone synthesis_Homo sapiens_hsa049180.34495515
107Metabolic pathways_Homo sapiens_hsa011000.34074905
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33470076
109Hematopoietic cell lineage_Homo sapiens_hsa046400.33365973
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32334982
111Autoimmune thyroid disease_Homo sapiens_hsa053200.32205409
112N-Glycan biosynthesis_Homo sapiens_hsa005100.31749697
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30749702
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30695448
115Focal adhesion_Homo sapiens_hsa045100.30217893
116Legionellosis_Homo sapiens_hsa051340.29880184
117Circadian rhythm_Homo sapiens_hsa047100.29572226
118Renin-angiotensin system_Homo sapiens_hsa046140.29420784
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29022472
120Allograft rejection_Homo sapiens_hsa053300.28962864
121Collecting duct acid secretion_Homo sapiens_hsa049660.28827011
122Vibrio cholerae infection_Homo sapiens_hsa051100.28507626
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28401576
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28371790
125Dilated cardiomyopathy_Homo sapiens_hsa054140.27941547
126Protein digestion and absorption_Homo sapiens_hsa049740.25014843
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23850802
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.23257670
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.23136962
130Linoleic acid metabolism_Homo sapiens_hsa005910.21432964
131AMPK signaling pathway_Homo sapiens_hsa041520.21278176
132Type II diabetes mellitus_Homo sapiens_hsa049300.19466163
133ECM-receptor interaction_Homo sapiens_hsa045120.19432916
134Insulin signaling pathway_Homo sapiens_hsa049100.17100154
135Amoebiasis_Homo sapiens_hsa051460.15884882
136Cocaine addiction_Homo sapiens_hsa050300.14909118
137Malaria_Homo sapiens_hsa051440.14428686
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13111193
139Mineral absorption_Homo sapiens_hsa049780.12360297
140Prolactin signaling pathway_Homo sapiens_hsa049170.09781124

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