FAM20B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.05012416
2Golgi transport vesicle coating (GO:0048200)4.91686969
3COPI coating of Golgi vesicle (GO:0048205)4.91686969
4nuclear pore organization (GO:0006999)4.60562831
5mitotic sister chromatid cohesion (GO:0007064)3.66157274
6mitotic chromosome condensation (GO:0007076)3.60128806
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52513467
8pore complex assembly (GO:0046931)3.47298270
9membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.41987723
10cellular protein complex localization (GO:0034629)3.41812647
11regulation of RNA export from nucleus (GO:0046831)3.38942879
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.35593435
13regulation of translational fidelity (GO:0006450)3.33517475
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32243055
15hippo signaling (GO:0035329)3.27411491
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.23235928
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.19652991
18activation of protein kinase A activity (GO:0034199)3.17925634
19cell communication by electrical coupling (GO:0010644)3.16841830
20regulation of nucleobase-containing compound transport (GO:0032239)3.15126544
21sodium ion export (GO:0071436)3.12976062
22paraxial mesoderm development (GO:0048339)3.07713946
23membrane repolarization during action potential (GO:0086011)3.02900007
24positive regulation of nuclease activity (GO:0032075)3.02723051
25cell-substrate junction assembly (GO:0007044)2.98703034
26cell communication involved in cardiac conduction (GO:0086065)2.98040951
27protein retention in ER lumen (GO:0006621)2.97655082
28regulation of early endosome to late endosome transport (GO:2000641)2.96900368
29DNA unwinding involved in DNA replication (GO:0006268)2.96471701
30insulin-like growth factor receptor signaling pathway (GO:0048009)2.96459070
31protein targeting to Golgi (GO:0000042)2.96258179
32plasma membrane repair (GO:0001778)2.90865804
33adherens junction assembly (GO:0034333)2.87990954
34focal adhesion assembly (GO:0048041)2.87695722
35cell-substrate adherens junction assembly (GO:0007045)2.87695722
36protein localization to endosome (GO:0036010)2.85442462
37regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.84910367
38protein complex localization (GO:0031503)2.84124274
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82595360
40positive regulation of vesicle fusion (GO:0031340)2.80767369
41vesicle coating (GO:0006901)2.80485200
42iron ion import (GO:0097286)2.77263550
43NLS-bearing protein import into nucleus (GO:0006607)2.76601675
44establishment of protein localization to Golgi (GO:0072600)2.76434592
45locomotory exploration behavior (GO:0035641)2.74798023
46protoporphyrinogen IX metabolic process (GO:0046501)2.73463501
47relaxation of cardiac muscle (GO:0055119)2.73266665
48regulation of nuclease activity (GO:0032069)2.70626955
49retrograde transport, vesicle recycling within Golgi (GO:0000301)2.69691235
50planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69349302
51endoplasmic reticulum unfolded protein response (GO:0030968)2.67067176
52cellular potassium ion homeostasis (GO:0030007)2.66219208
53layer formation in cerebral cortex (GO:0021819)2.66206591
54regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59677021
55cellular response to unfolded protein (GO:0034620)2.59178678
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57410633
57ER-nucleus signaling pathway (GO:0006984)2.56559934
58regulation of Rac protein signal transduction (GO:0035020)2.55038950
59exocrine pancreas development (GO:0031017)2.53902504
60synaptic vesicle maturation (GO:0016188)2.52821095
61negative regulation of potassium ion transmembrane transport (GO:1901380)2.51815146
62negative regulation of fatty acid transport (GO:2000192)2.50947950
63potassium ion import (GO:0010107)2.49605494
64proline transport (GO:0015824)2.48468937
65regulation of cAMP-dependent protein kinase activity (GO:2000479)2.47834181
66cell adhesion mediated by integrin (GO:0033627)2.46693632
67regulation of fatty acid beta-oxidation (GO:0031998)2.44466028
68tricarboxylic acid metabolic process (GO:0072350)2.43336969
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.43021769
70negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.41956866
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.41772654
72regulation of ARF protein signal transduction (GO:0032012)2.41308070
73protein localization to microtubule (GO:0035372)2.41162343
74desmosome organization (GO:0002934)2.40143365
75regulation of clathrin-mediated endocytosis (GO:2000369)2.39402565
76positive regulation of glycogen biosynthetic process (GO:0045725)2.39317205
77peptide hormone processing (GO:0016486)2.39201141
78regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.38950926
79positive regulation of histone deacetylation (GO:0031065)2.37977229
80macroautophagy (GO:0016236)2.37676305
81membrane repolarization (GO:0086009)2.37437814
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.37120888
83cerebellar Purkinje cell layer development (GO:0021680)2.36824303
84apoptotic cell clearance (GO:0043277)2.36822379
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36450932
86hemidesmosome assembly (GO:0031581)2.36367529
87protein export from nucleus (GO:0006611)2.36066079
88stress fiber assembly (GO:0043149)2.35814839
89protein hydroxylation (GO:0018126)2.35434686
90clathrin coat assembly (GO:0048268)2.35120966
91bundle of His cell to Purkinje myocyte communication (GO:0086069)2.34706829
92detection of calcium ion (GO:0005513)2.34552338
93cellular response to topologically incorrect protein (GO:0035967)2.33654870
94cellular response to vitamin (GO:0071295)2.33439016
95cardiac conduction (GO:0061337)2.33328728
96peptidyl-threonine modification (GO:0018210)2.33327554
97cellular response to vitamin D (GO:0071305)2.33063514
98collagen fibril organization (GO:0030199)2.32558175
99growth hormone secretion (GO:0030252)2.32091630
100regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31096289
101positive regulation of cell size (GO:0045793)2.31085982
102hypotonic response (GO:0006971)2.27803646
103vesicle transport along microtubule (GO:0047496)2.26898331
104regulation of centriole replication (GO:0046599)2.26481337
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26476226
106regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.25052352
107inner ear receptor cell development (GO:0060119)2.23806710
108positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.23783503
109establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.23314073
110peptidyl-threonine phosphorylation (GO:0018107)2.22863880
111myoblast fusion (GO:0007520)2.22394550
112UDP-N-acetylglucosamine metabolic process (GO:0006047)2.22154485
113regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.22134879
114cardiac myofibril assembly (GO:0055003)2.21682578
115sister chromatid segregation (GO:0000819)2.21588329
116notochord development (GO:0030903)2.21475747
117negative regulation of dendrite morphogenesis (GO:0050774)2.21245590
118Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.20735219
119Golgi organization (GO:0007030)2.20691054
120insulin secretion (GO:0030073)2.20685536
121negative regulation of catenin import into nucleus (GO:0035414)2.20304936
122ventricular cardiac muscle cell action potential (GO:0086005)2.20290691
123regulation of mitotic spindle organization (GO:0060236)2.20141897
124regulation of heart rate by cardiac conduction (GO:0086091)2.19904562
125cytoplasmic mRNA processing body assembly (GO:0033962)2.19896503
126negative regulation of cell size (GO:0045792)2.19709152
127response to endoplasmic reticulum stress (GO:0034976)2.19686967
128regulation of NFAT protein import into nucleus (GO:0051532)2.19315417
1294-hydroxyproline metabolic process (GO:0019471)2.19267496
130positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.18934483
131mRNA stabilization (GO:0048255)2.18484749
132RNA stabilization (GO:0043489)2.18484749
133regulation of polysaccharide biosynthetic process (GO:0032885)2.17662090
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.17529753
135endoplasmic reticulum organization (GO:0007029)2.17490828
136COPII vesicle coating (GO:0048208)2.17055683
137peptidyl-lysine dimethylation (GO:0018027)2.16666424
138epithelial cell-cell adhesion (GO:0090136)2.16141127
139pyrimidine ribonucleoside catabolic process (GO:0046133)2.13576005
140response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.13201994
141mitotic sister chromatid segregation (GO:0000070)2.12485617
142intestinal epithelial cell development (GO:0060576)2.12365307
143positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.11920678
144regulation of fatty acid oxidation (GO:0046320)2.10934576
145intestinal absorption (GO:0050892)2.10584307
146retina vasculature morphogenesis in camera-type eye (GO:0061299)2.10432930
147positive regulation of receptor recycling (GO:0001921)2.09065415
148alanine transport (GO:0032328)2.08472894
149tricarboxylic acid cycle (GO:0006099)2.08242875
150regulation of p38MAPK cascade (GO:1900744)2.08168282
151embryonic eye morphogenesis (GO:0048048)2.07926560
152potassium ion homeostasis (GO:0055075)2.07732509
153protein targeting to plasma membrane (GO:0072661)2.06137153
154regulation of establishment of planar polarity (GO:0090175)2.06063089
155DNA duplex unwinding (GO:0032508)2.06031040
156transcytosis (GO:0045056)2.05387465
157spindle assembly involved in mitosis (GO:0090307)2.04805189
158positive regulation of DNA-dependent DNA replication (GO:2000105)2.04714770
159establishment or maintenance of bipolar cell polarity (GO:0061245)2.04468518
160establishment or maintenance of apical/basal cell polarity (GO:0035088)2.04468518
161receptor recycling (GO:0001881)2.04359889
162regulation of glucose import in response to insulin stimulus (GO:2001273)2.04249271
163response to unfolded protein (GO:0006986)2.04056253
164carnitine shuttle (GO:0006853)2.03490814
165embryonic camera-type eye morphogenesis (GO:0048596)2.02945983
166myelination in peripheral nervous system (GO:0022011)2.02926391
167peripheral nervous system axon ensheathment (GO:0032292)2.02926391
168positive regulation of protein export from nucleus (GO:0046827)2.01581024
169negative regulation of potassium ion transport (GO:0043267)2.01034622
170positive regulation of glucose import (GO:0046326)2.00981898
171regulation of transforming growth factor beta2 production (GO:0032909)2.00719965
172glucocorticoid receptor signaling pathway (GO:0042921)1.99428097
173regulation of protein export from nucleus (GO:0046825)1.99333967
174midgut development (GO:0007494)1.99201627
175establishment of spindle localization (GO:0051293)1.98761037
176negative regulation of vascular permeability (GO:0043116)1.97606379
177negative regulation of peptidyl-threonine phosphorylation (GO:0010801)1.96283469
178cortical actin cytoskeleton organization (GO:0030866)1.96006203

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67471299
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.89569339
3AR_21909140_ChIP-Seq_LNCAP_Human2.86426805
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.59958582
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.40764701
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23728857
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.22553642
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.19866746
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17981779
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.17040450
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97802251
12CLOCK_20551151_ChIP-Seq_293T_Human1.94627261
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94301899
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89379855
15GATA1_22025678_ChIP-Seq_K562_Human1.86669717
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82855252
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81588903
18ZNF263_19887448_ChIP-Seq_K562_Human1.75663695
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74190979
20EZH2_22144423_ChIP-Seq_EOC_Human1.68007896
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.67844753
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67745901
23DROSHA_22980978_ChIP-Seq_HELA_Human1.57332490
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54628565
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52215386
26* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51307013
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.49371873
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48556747
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.47169311
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46768778
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46657677
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46215202
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44850971
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44761046
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43705580
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42756668
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41718925
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41672656
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39039741
40ZNF274_21170338_ChIP-Seq_K562_Hela1.38318048
41* KDM2B_26808549_Chip-Seq_K562_Human1.35976871
42* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34479859
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34296738
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34042077
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.32130564
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.31369290
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30151396
48* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28904623
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28184386
50TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27945570
51* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27911727
52NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27746841
53SOX2_20726797_ChIP-Seq_SW620_Human1.27173493
54* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27137899
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.27124538
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.26763632
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.26763632
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26686585
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.26158913
60* GATA1_19941826_ChIP-Seq_K562_Human1.25902344
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25509522
62AHR_22903824_ChIP-Seq_MCF-7_Human1.24405823
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24375880
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23295738
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23295738
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23290455
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23256173
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23224574
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22110572
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20670385
71RXR_22108803_ChIP-Seq_LS180_Human1.20361611
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19928237
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19643320
74* CHD1_26751641_Chip-Seq_LNCaP_Human1.19591491
75BRD4_25478319_ChIP-Seq_HGPS_Human1.18483364
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18240390
77EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17066217
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16427176
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15871093
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15655273
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15610661
82* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15214930
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.15018164
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.14987965
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14576531
86* GATA2_19941826_ChIP-Seq_K562_Human1.12750289
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12211732
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.11170445
89GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09469249
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09452603
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08607456
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08191220
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.07771899
94* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07694916
95* GATA2_21666600_ChIP-Seq_HMVEC_Human1.06812719
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06708728
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06587858
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06254625
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05385482
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05269326
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05142160
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04270809
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03931106
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03743599
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03510332
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02671680
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01968282
108* RACK7_27058665_Chip-Seq_MCF-7_Human1.01108587
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.00986809
110* GATA4_25053715_ChIP-Seq_YYC3_Human1.00704750
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.00103509
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99775883
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99775883
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99693794
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99247835
116SOX2_21211035_ChIP-Seq_LN229_Gbm0.99131623
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99108425
118* CREB1_26743006_Chip-Seq_LNCaP_Human0.98808294
119PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98604595
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98568747
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98395272
122AR_19668381_ChIP-Seq_PC3_Human0.96939313
123GATA6_25053715_ChIP-Seq_YYC3_Human0.96835934
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.96746675
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96413512
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95811200
127* TP63_23658742_ChIP-Seq_EP156T_Human0.95241196
128ATF3_27146783_Chip-Seq_COLON_Human0.95026002
129TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94904257
130SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94851991
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.94522465
132E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94372934
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94271389
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94261776
135* CJUN_26792858_Chip-Seq_BT549_Human0.94253380
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.93988563
137RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93733754
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93678929
139BCAT_22108803_ChIP-Seq_LS180_Human0.93585362
140LXR_22292898_ChIP-Seq_THP-1_Human0.93317343
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93299807
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.93058220
143SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92696794
144SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92696794
145ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92472123
146DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92228218
147RNF2_27304074_Chip-Seq_ESCs_Mouse0.92026634
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90872844
149SMAD4_21799915_ChIP-Seq_A2780_Human0.90844821
150TP53_16413492_ChIP-PET_HCT116_Human0.90699026
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90340115
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89979958
153HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89675377
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89604637
155* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85901718
156ISL1_27105846_Chip-Seq_CPCs_Mouse0.85866965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.32358990
2MP0009780_abnormal_chondrocyte_physiolo4.06782048
3MP0003300_gastrointestinal_ulcer3.67042318
4MP0003705_abnormal_hypodermis_morpholog3.33685488
5MP0003283_abnormal_digestive_organ3.31079105
6MP0002909_abnormal_adrenal_gland2.92946698
7MP0002877_abnormal_melanocyte_morpholog2.74075967
8MP0000013_abnormal_adipose_tissue2.72617121
9MP0004043_abnormal_pH_regulation2.57738189
10MP0002837_dystrophic_cardiac_calcinosis2.55335115
11MP0008961_abnormal_basal_metabolism2.16949213
12MP0000566_synostosis2.12407641
13MP0003045_fibrosis2.07418511
14MP0004264_abnormal_extraembryonic_tissu2.04128609
15MP0004130_abnormal_muscle_cell2.03640138
16MP0003950_abnormal_plasma_membrane2.02896741
17MP0004859_abnormal_synaptic_plasticity1.96861953
18MP0005670_abnormal_white_adipose1.94289503
19MP0000751_myopathy1.90121686
20MP0005409_darkened_coat_color1.89735699
21MP0002896_abnormal_bone_mineralization1.82440912
22MP0008057_abnormal_DNA_replication1.82373541
23MP0003941_abnormal_skin_development1.76112932
24MP0000003_abnormal_adipose_tissue1.73979651
25MP0005083_abnormal_biliary_tract1.73593370
26MP0001661_extended_life_span1.72151371
27MP0001765_abnormal_ion_homeostasis1.69633896
28MP0005666_abnormal_adipose_tissue1.69205408
29MP0000749_muscle_degeneration1.61733946
30MP0004858_abnormal_nervous_system1.58939940
31MP0005375_adipose_tissue_phenotype1.57329404
32MP0010386_abnormal_urinary_bladder1.56495659
33MP0004270_analgesia1.52901144
34MP0003566_abnormal_cell_adhesion1.52384185
35MP0005171_absent_coat_pigmentation1.50794731
36MP0004084_abnormal_cardiac_muscle1.50372677
37MP0006054_spinal_hemorrhage1.50165936
38MP0003183_abnormal_peptide_metabolism1.47928890
39MP0005275_abnormal_skin_tensile1.45770219
40MP0000733_abnormal_muscle_development1.44909055
41MP0010352_gastrointestinal_tract_polyps1.43803025
42MP0004185_abnormal_adipocyte_glucose1.42162432
43MP0000428_abnormal_craniofacial_morphol1.41828820
44MP0001944_abnormal_pancreas_morphology1.38803856
45MP0004215_abnormal_myocardial_fiber1.34167242
46MP0001666_abnormal_nutrient_absorption1.33352779
47MP0004233_abnormal_muscle_weight1.33183628
48MP0000537_abnormal_urethra_morphology1.32857231
49MP0000759_abnormal_skeletal_muscle1.32355694
50MP0004272_abnormal_basement_membrane1.31061535
51MP0002234_abnormal_pharynx_morphology1.25892637
52MP0001348_abnormal_lacrimal_gland1.25661845
53MP0003172_abnormal_lysosome_physiology1.24858532
54MP0004147_increased_porphyrin_level1.24661640
55MP0002693_abnormal_pancreas_physiology1.24624143
56MP0003656_abnormal_erythrocyte_physiolo1.24463340
57MP0001299_abnormal_eye_distance/1.24209381
58MP0006138_congestive_heart_failure1.23605761
59MP0005503_abnormal_tendon_morphology1.23007290
60MP0002060_abnormal_skin_morphology1.22209900
61MP0005623_abnormal_meninges_morphology1.21715641
62MP0003252_abnormal_bile_duct1.21334051
63MP0009384_cardiac_valve_regurgitation1.18179426
64MP0008438_abnormal_cutaneous_collagen1.17943925
65MP0002078_abnormal_glucose_homeostasis1.17827585
66MP0005257_abnormal_intraocular_pressure1.17782038
67MP0001756_abnormal_urination1.16835807
68MP0000538_abnormal_urinary_bladder1.15594134
69MP0002796_impaired_skin_barrier1.14082463
70MP0005408_hypopigmentation1.11097482
71MP0004484_altered_response_of1.10997496
72MP0001849_ear_inflammation1.10335102
73MP0000747_muscle_weakness1.10198542
74MP0004036_abnormal_muscle_relaxation1.09199648
75MP0004087_abnormal_muscle_fiber1.07976735
76MP0000579_abnormal_nail_morphology1.06518268
77MP0010368_abnormal_lymphatic_system1.06158861
78MP0000569_abnormal_digit_pigmentation1.04193240
79MP0009053_abnormal_anal_canal1.02815104
80MP0003984_embryonic_growth_retardation1.02255215
81MP0005076_abnormal_cell_differentiation1.01380071
82MP0000762_abnormal_tongue_morphology1.01035092
83MP0002928_abnormal_bile_duct1.00807048
84MP0002084_abnormal_developmental_patter1.00802425
85MP0003195_calcinosis1.00277033
86MP0001958_emphysema1.00124892
87MP0002009_preneoplasia0.99624365
88MP0010307_abnormal_tumor_latency0.99549306
89MP0000534_abnormal_ureter_morphology0.99332042
90MP0003111_abnormal_nucleus_morphology0.99038184
91MP0002086_abnormal_extraembryonic_tissu0.99011909
92MP0004957_abnormal_blastocyst_morpholog0.98667264
93MP0003942_abnormal_urinary_system0.98363793
94MP0009643_abnormal_urine_homeostasis0.98343944
95MP0005380_embryogenesis_phenotype0.95951231
96MP0001672_abnormal_embryogenesis/_devel0.95951231
97MP0001915_intracranial_hemorrhage0.95932609
98MP0000350_abnormal_cell_proliferation0.95397271
99MP0002088_abnormal_embryonic_growth/wei0.95366339
100MP0008004_abnormal_stomach_pH0.95209182
101MP0005620_abnormal_muscle_contractility0.95127221
102MP0002972_abnormal_cardiac_muscle0.94618805
103MP0003635_abnormal_synaptic_transmissio0.94544953
104MP0005330_cardiomyopathy0.94526943
105MP0001697_abnormal_embryo_size0.93330389
106MP0000767_abnormal_smooth_muscle0.92855206
107MP0003115_abnormal_respiratory_system0.92460540
108MP0003123_paternal_imprinting0.92204972
109MP0003385_abnormal_body_wall0.91321656
110MP0002089_abnormal_postnatal_growth/wei0.90719906
111MP0001730_embryonic_growth_arrest0.90142947
112MP0008775_abnormal_heart_ventricle0.88455199
113MP0005058_abnormal_lysosome_morphology0.88348717
114MP0000467_abnormal_esophagus_morphology0.87835313
115MP0002269_muscular_atrophy0.87610884
116MP0010030_abnormal_orbit_morphology0.87505780
117MP0010630_abnormal_cardiac_muscle0.86408266
118MP0000462_abnormal_digestive_system0.85875262
119MP0003937_abnormal_limbs/digits/tail_de0.85684815
120MP0001270_distended_abdomen0.85539148
121MP0009672_abnormal_birth_weight0.84905102
122MP0004134_abnormal_chest_morphology0.82890507
123MP0005220_abnormal_exocrine_pancreas0.82776076
124MP0002697_abnormal_eye_size0.82497585
125MP0001664_abnormal_digestion0.81763730
126MP0003646_muscle_fatigue0.81532034
127MP0004197_abnormal_fetal_growth/weight/0.81299533
128MP0002080_prenatal_lethality0.81297870
129MP0002085_abnormal_embryonic_tissue0.80914029
130MP0003959_abnormal_lean_body0.80296987
131MP0005187_abnormal_penis_morphology0.80103847
132MP0003122_maternal_imprinting0.78008214
133MP0000432_abnormal_head_morphology0.77928543
134MP0004145_abnormal_muscle_electrophysio0.77478433
135MP0003935_abnormal_craniofacial_develop0.76772143
136MP0000230_abnormal_systemic_arterial0.76708986
137MP0005167_abnormal_blood-brain_barrier0.76447682
138MP0003953_abnormal_hormone_level0.75777128
139MP0003075_altered_response_to0.75673405
140MP0003329_amyloid_beta_deposits0.74956059
141MP0002168_other_aberrant_phenotype0.74448129
142MP0005451_abnormal_body_composition0.74016074
143MP0002106_abnormal_muscle_physiology0.73385439
144MP0003077_abnormal_cell_cycle0.72616920
145MP0000750_abnormal_muscle_regeneration0.71569304
146MP0005334_abnormal_fat_pad0.71220043
147MP0003787_abnormal_imprinting0.67969551
148MP0005535_abnormal_body_temperature0.67832726
149MP0002063_abnormal_learning/memory/cond0.67766090
150MP0004085_abnormal_heartbeat0.66861155
151MP0002734_abnormal_mechanical_nocicepti0.66771156
152MP0010678_abnormal_skin_adnexa0.66745871
153MP0003091_abnormal_cell_migration0.65198385
154MP0002138_abnormal_hepatobiliary_system0.62360847
155MP0002108_abnormal_muscle_morphology0.62042043
156MP0002166_altered_tumor_susceptibility0.61733098
157MP0010329_abnormal_lipoprotein_level0.61387951
158MP0004885_abnormal_endolymph0.61233803
159MP0004947_skin_inflammation0.60892657

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.70651107
2Protrusio acetabuli (HP:0003179)3.40504939
3Premature rupture of membranes (HP:0001788)3.39829662
4Right ventricular cardiomyopathy (HP:0011663)3.38027227
5Ketoacidosis (HP:0001993)2.89525675
6Papilledema (HP:0001085)2.79937794
7Sparse lateral eyebrow (HP:0005338)2.70122434
8Asymmetry of the thorax (HP:0001555)2.64867655
9Arterial tortuosity (HP:0005116)2.64694649
10Bundle branch block (HP:0011710)2.64614897
11Ventricular fibrillation (HP:0001663)2.63658090
12Cerebral aneurysm (HP:0004944)2.60171114
13Vascular tortuosity (HP:0004948)2.57139122
14Increased connective tissue (HP:0009025)2.49421091
15Mildly elevated creatine phosphokinase (HP:0008180)2.44952052
16Macroorchidism (HP:0000053)2.44696954
17Hyperactive renin-angiotensin system (HP:0000841)2.43696884
18Hyperinsulinemic hypoglycemia (HP:0000825)2.43649879
19Insulin-resistant diabetes mellitus (HP:0000831)2.35885527
20Gout (HP:0001997)2.35824859
21Hypercortisolism (HP:0001578)2.34143921
22Bladder diverticulum (HP:0000015)2.32045469
23Long toe (HP:0010511)2.28495451
24Enlarged penis (HP:0000040)2.25844296
25Abnormal pancreas size (HP:0012094)2.24581117
26Abnormality of chloride homeostasis (HP:0011422)2.24401847
27Urinary glycosaminoglycan excretion (HP:0003541)2.23956791
28Mucopolysacchariduria (HP:0008155)2.23956791
29Lymphangioma (HP:0100764)2.23912942
30Exercise-induced myalgia (HP:0003738)2.23628279
31Hand muscle atrophy (HP:0009130)2.23250312
32Type 1 muscle fiber predominance (HP:0003803)2.22276377
33Resting tremor (HP:0002322)2.20466543
34Vertebral arch anomaly (HP:0008438)2.18960547
35Hyporeflexia of lower limbs (HP:0002600)2.18827732
36Aortic dissection (HP:0002647)2.15503355
37Subacute progressive viral hepatitis (HP:0006572)2.11559116
38Thin bony cortex (HP:0002753)2.11286278
39Hyperglycemia (HP:0003074)2.10062430
40Shallow orbits (HP:0000586)2.09793123
41Hypoglycemic coma (HP:0001325)2.09199463
42Hyperacusis (HP:0010780)2.08437779
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.07497523
44Osteolytic defects of the hand bones (HP:0009699)2.07497523
45Abnormality of polysaccharide metabolism (HP:0011012)2.07396867
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07396867
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07396867
48Relative macrocephaly (HP:0004482)2.06975526
49Hypoplastic ischia (HP:0003175)2.06780386
50Pheochromocytoma (HP:0002666)2.05673894
51Ankle contracture (HP:0006466)2.05580415
52Flat acetabular roof (HP:0003180)2.04792018
53Myoglobinuria (HP:0002913)2.04694369
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04352673
55Distal upper limb amyotrophy (HP:0007149)2.04195761
56Upper limb amyotrophy (HP:0009129)2.04195761
57Aortic aneurysm (HP:0004942)2.03284472
58Obstructive sleep apnea (HP:0002870)2.02492001
59Ulnar bowing (HP:0003031)2.01759823
60Popliteal pterygium (HP:0009756)2.01654463
61Cervical subluxation (HP:0003308)2.00456944
62Sudden death (HP:0001699)2.00216081
63Termporal pattern (HP:0011008)2.00173425
64Insidious onset (HP:0003587)2.00173425
65Increased circulating renin level (HP:0000848)1.99513538
66Disproportionate tall stature (HP:0001519)1.98082936
67Ankyloglossia (HP:0010296)1.98061346
68Exostoses (HP:0100777)1.96897911
69Protuberant abdomen (HP:0001538)1.96369664
70Wormian bones (HP:0002645)1.95760879
71Deep philtrum (HP:0002002)1.93912278
72Abnormality of calcium-phosphate metabolism (HP:0100530)1.93461063
73Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93404606
74Hypokalemia (HP:0002900)1.93353507
75Scapular winging (HP:0003691)1.92452793
76Metaphyseal cupping (HP:0003021)1.92108188
77Abnormality of the phalanges of the hallux (HP:0010057)1.91262247
78Hyperparathyroidism (HP:0000843)1.91084528
79Visual hallucinations (HP:0002367)1.90461098
80Increased nuchal translucency (HP:0010880)1.90238928
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.89627474
82Overgrowth (HP:0001548)1.89114474
83Dysmetric saccades (HP:0000641)1.89075146
84Neonatal short-limb short stature (HP:0008921)1.88979036
85Mitral regurgitation (HP:0001653)1.88847289
86Aneurysm (HP:0002617)1.88795805
87Flat cornea (HP:0007720)1.88590463
88Epiphyseal dysplasia (HP:0002656)1.88183599
89Difficulty running (HP:0009046)1.86670429
90Hypoglycemic seizures (HP:0002173)1.86473967
91Syncope (HP:0001279)1.85089139
92Elfin facies (HP:0004428)1.84591649
93Abnormality of oral frenula (HP:0000190)1.83854429
94Adrenal overactivity (HP:0002717)1.83546428
95Hamartoma of the eye (HP:0010568)1.83390697
96Rectal prolapse (HP:0002035)1.83050710
97Metabolic alkalosis (HP:0200114)1.82805620
98Coronal craniosynostosis (HP:0004440)1.82543283
99Follicular hyperkeratosis (HP:0007502)1.80854980
100Advanced eruption of teeth (HP:0006288)1.80585201
101Patellar dislocation (HP:0002999)1.78782505
102Agitation (HP:0000713)1.78767334
103Abnormality of the ischium (HP:0003174)1.78463060
104Nemaline bodies (HP:0003798)1.78380570
105Renal duplication (HP:0000075)1.78012249
106Exercise-induced muscle cramps (HP:0003710)1.77783994
107Heterotopia (HP:0002282)1.77521225
108Spinal cord lesions (HP:0100561)1.77481719
109Syringomyelia (HP:0003396)1.77481719
110Abdominal distention (HP:0003270)1.77278733
111Conjunctival hamartoma (HP:0100780)1.77274425
112Hypokalemic alkalosis (HP:0001949)1.76780715
113Late onset (HP:0003584)1.76750817
114Natal tooth (HP:0000695)1.76668647
115Renovascular hypertension (HP:0100817)1.76323308
116Missing ribs (HP:0000921)1.76227087
117Muscle fiber inclusion bodies (HP:0100299)1.76012871
118Fragile skin (HP:0001030)1.76000134
119Dysostosis multiplex (HP:0000943)1.75442384
120Cubitus valgus (HP:0002967)1.74857269
121Increased variability in muscle fiber diameter (HP:0003557)1.74661143
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.74474873
123Asymmetric septal hypertrophy (HP:0001670)1.74303118
124Mitral stenosis (HP:0001718)1.72912646
125Insomnia (HP:0100785)1.72791846
126Lower limb amyotrophy (HP:0007210)1.72234584
127Symptomatic seizures (HP:0011145)1.71784384
128Mitral valve prolapse (HP:0001634)1.71190884
129Distal lower limb amyotrophy (HP:0008944)1.71054428
130Abnormality of renin-angiotensin system (HP:0000847)1.69920570
131Abnormality of potassium homeostasis (HP:0011042)1.68986623
132Achilles tendon contracture (HP:0001771)1.68872194
133Bowel diverticulosis (HP:0005222)1.68720198
134Pterygium (HP:0001059)1.67183094
135Difficulty climbing stairs (HP:0003551)1.66095151
136Abnormality of the fingertips (HP:0001211)1.65953262
137Hammertoe (HP:0001765)1.65717572
138Ventricular arrhythmia (HP:0004308)1.64886552
139Abnormality of the gastric mucosa (HP:0004295)1.64718962
140Soft skin (HP:0000977)1.64690549
141Progressive sensorineural hearing impairment (HP:0000408)1.63890226
142Exocrine pancreatic insufficiency (HP:0001738)1.63858630
143Buphthalmos (HP:0000557)1.63847603
144Hyperextensible skin (HP:0000974)1.63502702
145Overriding aorta (HP:0002623)1.63365949
146Hematochezia (HP:0002573)1.63270047
147Increased CSF protein (HP:0002922)1.62623140
148Reticulocytosis (HP:0001923)1.61955017
149Prolonged QT interval (HP:0001657)1.61807486
150Thin ribs (HP:0000883)1.61731642
151Visceral angiomatosis (HP:0100761)1.59977287
152Atrioventricular block (HP:0001678)1.59908484
153Hypoventilation (HP:0002791)1.59905331
154Spinal rigidity (HP:0003306)1.59827882
155Alopecia of scalp (HP:0002293)1.59426099
156Severe short stature (HP:0003510)1.59140079
157Back pain (HP:0003418)1.58768410
158Abnormality of skeletal muscle fiber size (HP:0012084)1.58188704
159Ketosis (HP:0001946)1.57562837
160Atrophic scars (HP:0001075)1.56830374
161Fetal akinesia sequence (HP:0001989)1.56694819
162Thoracolumbar scoliosis (HP:0002944)1.56584269
163Abnormality of the left ventricular outflow tract (HP:0011103)1.56204819
164Subaortic stenosis (HP:0001682)1.56204819
165Precocious puberty (HP:0000826)1.55532150
166Aplasia involving bones of the upper limbs (HP:0009823)1.55484127
167Aplasia of the phalanges of the hand (HP:0009802)1.55484127
168Aplasia involving bones of the extremities (HP:0009825)1.55484127
169Abnormality of the acetabulum (HP:0003170)1.55010175
170Abnormality of the Achilles tendon (HP:0005109)1.53604379
171Abnormality of the calcaneus (HP:0008364)1.52988865
172Poikilocytosis (HP:0004447)1.52859702
173Leiomyosarcoma (HP:0100243)1.50150140
174Uterine leiomyosarcoma (HP:0002891)1.50150140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.37072108
2RIPK13.64479992
3FRK3.19996211
4LMTK22.92474186
5PKN22.71386104
6EIF2AK12.67647135
7PRKD32.45504481
8ICK2.33380036
9PDGFRA2.13709371
10MAP3K22.12046505
11PTK62.08970726
12STK32.03336736
13TTN2.02397163
14ERN11.99480923
15STK241.95340187
16NTRK31.91766984
17MAP3K91.84015533
18DDR21.74151694
19PDK41.66180085
20PDK31.66180085
21IRAK31.58962975
22TTK1.57799300
23SCYL21.57493146
24CAMKK11.56630239
25CDK121.56267854
26MET1.55678350
27WNK41.54525325
28PRPF4B1.49883346
29DMPK1.48971693
30INSRR1.41835275
31FER1.41481517
32MKNK21.37379943
33NTRK11.35943300
34RET1.35466890
35WNK31.35210205
36KSR21.28711740
37RPS6KB21.22642752
38SIK11.22407264
39PNCK1.22363148
40NEK91.21239761
41LATS11.21238017
42PBK1.19093160
43PHKG11.14937268
44PHKG21.14937268
45AKT31.13364713
46PRKCH1.10278284
47EEF2K1.07852423
48PDK21.06655681
49PTK21.04659447
50CDC71.04145014
51STK381.03700582
52CHEK21.01491813
53NEK21.00771623
54MAP3K10.98858774
55MST1R0.98353560
56FGFR30.97967717
57MAP3K40.96964497
58PAK30.95148981
59ERBB40.94800013
60CCNB10.91929919
61MYLK0.90923323
62SGK30.88987783
63HIPK20.88684141
64LRRK20.87718735
65WNK10.87554390
66STK390.86358200
67PRKG20.84751389
68JAK10.83243088
69MAP2K10.82978403
70PASK0.82953767
71PDGFRB0.82360868
72TAOK30.82244164
73CAMKK20.80984401
74PDPK10.80451506
75PDK10.80311555
76SMG10.80227127
77PAK40.79591092
78DAPK20.78758594
79NEK10.78444136
80MAP2K40.78325657
81CDC42BPA0.77876073
82PIK3CA0.77506139
83YES10.72647427
84ALK0.71291980
85PAK60.71191725
86AKT20.70179436
87EPHB20.69025836
88MAP3K70.68719540
89MAPK110.68201111
90RPS6KB10.66771308
91STK38L0.66231825
92TAOK10.65785252
93CLK10.64982672
94TNIK0.64913994
95MINK10.64532207
96MELK0.64509832
97WEE10.62759071
98LATS20.62151311
99KSR10.61382487
100BMX0.60742735
101TYRO30.60266099
102CDK50.60144706
103EPHA40.60095439
104STK40.59509776
105CAMK1G0.58680537
106CAMK1D0.58105780
107MAPKAPK30.56749534
108BRSK20.55820324
109OBSCN0.55274472
110ROCK10.54968742
111MTOR0.53745792
112PRKAA10.53504072
113MUSK0.51773894
114SGK20.51730191
115MAPK100.50688905
116CDK60.50555742
117JAK20.48904785
118MAP3K100.48694982
119TESK10.48628850
120FGFR20.48300475
121MAP3K60.46574908
122FGFR40.46331333
123SGK10.46178436
124PRKD10.45059913
125CAMK40.44761509
126DYRK1B0.44690899
127FGFR10.41512234
128CHEK10.41052882
129OXSR10.40470573
130TSSK60.40314999
131TGFBR20.39997518
132RAF10.39544558
133STK110.39053872
134MAP3K30.39027435
135RPS6KA20.38679038
136CDK70.38541484
137TRPM70.38435028
138ILK0.38427550
139BRSK10.38208336
140PRKCG0.38044165
141FLT30.38024067
142SGK2230.36793560
143SGK4940.36793560
144PAK20.36112355
145CSNK1E0.36010433
146PTK2B0.35621906
147CDK10.35329283
148RIPK40.35315166
149GSK3A0.33939898
150BRAF0.33669855
151MARK10.33197979
152MAP3K120.32575786

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17952576
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02147344
3Maturity onset diabetes of the young_Homo sapiens_hsa049501.92650879
4Insulin secretion_Homo sapiens_hsa049111.85985465
5Carbohydrate digestion and absorption_Homo sapiens_hsa049731.61537020
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61520992
7Gastric acid secretion_Homo sapiens_hsa049711.60837158
8Type II diabetes mellitus_Homo sapiens_hsa049301.59928989
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56244055
10Renal cell carcinoma_Homo sapiens_hsa052111.55294609
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54035176
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52397091
13Thyroid cancer_Homo sapiens_hsa052161.48617213
14Pancreatic secretion_Homo sapiens_hsa049721.41300572
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34220430
16Protein digestion and absorption_Homo sapiens_hsa049741.34045220
17Pancreatic cancer_Homo sapiens_hsa052121.33628598
18Long-term potentiation_Homo sapiens_hsa047201.31135261
19MicroRNAs in cancer_Homo sapiens_hsa052061.31050832
20Arginine biosynthesis_Homo sapiens_hsa002201.30195757
21Small cell lung cancer_Homo sapiens_hsa052221.29270934
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28792004
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28728176
24Renin secretion_Homo sapiens_hsa049241.28278392
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27720896
26mTOR signaling pathway_Homo sapiens_hsa041501.27412288
27Hippo signaling pathway_Homo sapiens_hsa043901.27005122
28Dilated cardiomyopathy_Homo sapiens_hsa054141.24505902
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21885766
30Thyroid hormone synthesis_Homo sapiens_hsa049181.21207777
31Sulfur metabolism_Homo sapiens_hsa009201.20926796
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19494234
33Salivary secretion_Homo sapiens_hsa049701.17777516
34Synaptic vesicle cycle_Homo sapiens_hsa047211.16014143
35Estrogen signaling pathway_Homo sapiens_hsa049151.15213919
36Insulin resistance_Homo sapiens_hsa049311.14702925
37Glioma_Homo sapiens_hsa052141.11883586
38Glucagon signaling pathway_Homo sapiens_hsa049221.11255390
39Amphetamine addiction_Homo sapiens_hsa050311.09064308
40Nitrogen metabolism_Homo sapiens_hsa009101.08558737
41Melanoma_Homo sapiens_hsa052181.07962161
42Prostate cancer_Homo sapiens_hsa052151.07641782
43Circadian entrainment_Homo sapiens_hsa047131.06888263
44Insulin signaling pathway_Homo sapiens_hsa049101.04183412
45Focal adhesion_Homo sapiens_hsa045101.03593788
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03048455
47GnRH signaling pathway_Homo sapiens_hsa049121.02248988
48Cell cycle_Homo sapiens_hsa041101.02174750
49Vitamin B6 metabolism_Homo sapiens_hsa007500.99275889
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99005329
51Dorso-ventral axis formation_Homo sapiens_hsa043200.98818961
52Dopaminergic synapse_Homo sapiens_hsa047280.98787732
53Olfactory transduction_Homo sapiens_hsa047400.98265467
54Vibrio cholerae infection_Homo sapiens_hsa051100.97988430
55Bile secretion_Homo sapiens_hsa049760.97481047
56Endometrial cancer_Homo sapiens_hsa052130.97130285
57Cholinergic synapse_Homo sapiens_hsa047250.96137993
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94685470
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94320947
60TGF-beta signaling pathway_Homo sapiens_hsa043500.93544323
61Cocaine addiction_Homo sapiens_hsa050300.92883983
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89861552
63Fatty acid degradation_Homo sapiens_hsa000710.87830394
64ECM-receptor interaction_Homo sapiens_hsa045120.86994912
65Oxytocin signaling pathway_Homo sapiens_hsa049210.86973410
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86759882
67Gap junction_Homo sapiens_hsa045400.86126941
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84626313
69Choline metabolism in cancer_Homo sapiens_hsa052310.83808858
70Proteoglycans in cancer_Homo sapiens_hsa052050.83403743
71GABAergic synapse_Homo sapiens_hsa047270.82623937
72Colorectal cancer_Homo sapiens_hsa052100.81005485
73AMPK signaling pathway_Homo sapiens_hsa041520.80504791
74Fat digestion and absorption_Homo sapiens_hsa049750.79520175
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78601809
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78116313
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.77616056
78Adherens junction_Homo sapiens_hsa045200.77543323
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76904237
80FoxO signaling pathway_Homo sapiens_hsa040680.75461120
81Mineral absorption_Homo sapiens_hsa049780.73840771
82VEGF signaling pathway_Homo sapiens_hsa043700.73752509
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.73583127
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73307727
85mRNA surveillance pathway_Homo sapiens_hsa030150.73134242
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72287398
87Propanoate metabolism_Homo sapiens_hsa006400.71777890
88cAMP signaling pathway_Homo sapiens_hsa040240.71381064
89Circadian rhythm_Homo sapiens_hsa047100.71319020
90Prion diseases_Homo sapiens_hsa050200.71122845
91Fatty acid biosynthesis_Homo sapiens_hsa000610.70903922
92One carbon pool by folate_Homo sapiens_hsa006700.70565829
93Inositol phosphate metabolism_Homo sapiens_hsa005620.69670764
94Lysosome_Homo sapiens_hsa041420.69468122
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.68632609
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.68549263
97Taste transduction_Homo sapiens_hsa047420.68506888
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67542162
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67482262
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67303195
101Melanogenesis_Homo sapiens_hsa049160.67138032
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.67031925
103Amoebiasis_Homo sapiens_hsa051460.67020393
104Bladder cancer_Homo sapiens_hsa052190.66910342
105Glutamatergic synapse_Homo sapiens_hsa047240.66214790
106Pathways in cancer_Homo sapiens_hsa052000.66045580
107Tight junction_Homo sapiens_hsa045300.65380842
108Wnt signaling pathway_Homo sapiens_hsa043100.65349631
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65124341
110Non-small cell lung cancer_Homo sapiens_hsa052230.64932380
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64353527
112Axon guidance_Homo sapiens_hsa043600.64157785
113Glycerolipid metabolism_Homo sapiens_hsa005610.64039265
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62909552
115Morphine addiction_Homo sapiens_hsa050320.62714560
116Long-term depression_Homo sapiens_hsa047300.62016881
117Starch and sucrose metabolism_Homo sapiens_hsa005000.61998558
118Chronic myeloid leukemia_Homo sapiens_hsa052200.61550945
119Fatty acid metabolism_Homo sapiens_hsa012120.61415203
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60848503
121Oocyte meiosis_Homo sapiens_hsa041140.60456263
122Selenocompound metabolism_Homo sapiens_hsa004500.60117428
123Prolactin signaling pathway_Homo sapiens_hsa049170.60018224
124Renin-angiotensin system_Homo sapiens_hsa046140.60000873
125PPAR signaling pathway_Homo sapiens_hsa033200.59825951
126Butanoate metabolism_Homo sapiens_hsa006500.59175676
127Lysine degradation_Homo sapiens_hsa003100.59033971
128ErbB signaling pathway_Homo sapiens_hsa040120.58916170
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58565472
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58361430
131Calcium signaling pathway_Homo sapiens_hsa040200.58076912
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.55912067
133HIF-1 signaling pathway_Homo sapiens_hsa040660.54665300
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54583754
135Non-homologous end-joining_Homo sapiens_hsa034500.54416015
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54289134
137N-Glycan biosynthesis_Homo sapiens_hsa005100.53625251
138Biosynthesis of amino acids_Homo sapiens_hsa012300.53453263
139Acute myeloid leukemia_Homo sapiens_hsa052210.52961410
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52103787
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.51845835
142Rap1 signaling pathway_Homo sapiens_hsa040150.51746037

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