FAM20C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.83813904
2modulation by symbiont of host immune response (GO:0052553)5.83813904
3positive regulation by symbiont of host defense response (GO:0052509)5.83813904
4modulation by symbiont of host defense response (GO:0052031)5.83813904
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.83813904
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.83813904
7adhesion of symbiont to host cell (GO:0044650)4.80011555
8virion attachment to host cell (GO:0019062)4.80011555
9barbed-end actin filament capping (GO:0051016)4.56819382
10macrophage activation involved in immune response (GO:0002281)4.42379670
11adhesion of symbiont to host (GO:0044406)4.30779097
12glycosphingolipid catabolic process (GO:0046479)4.13596684
13response to peptidoglycan (GO:0032494)3.92194805
14protein localization to endosome (GO:0036010)3.87947951
15macroautophagy (GO:0016236)3.87025412
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84578715
17response to host immune response (GO:0052572)3.84578715
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.83566758
19low-density lipoprotein particle clearance (GO:0034383)3.82284316
20hydrogen peroxide biosynthetic process (GO:0050665)3.79496394
21positive regulation of cellular amide metabolic process (GO:0034250)3.79427508
22neutrophil activation involved in immune response (GO:0002283)3.78237791
23amino sugar catabolic process (GO:0046348)3.77599259
24cellular response to thyroid hormone stimulus (GO:0097067)3.72773860
25regulation of cholesterol storage (GO:0010885)3.69082607
26positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.69079860
27glycolipid catabolic process (GO:0019377)3.68556499
28regulation of interferon-beta biosynthetic process (GO:0045357)3.66704497
29endodermal cell differentiation (GO:0035987)3.62950166
30I-kappaB phosphorylation (GO:0007252)3.61234482
31oligosaccharide catabolic process (GO:0009313)3.60451411
32positive regulation of extracellular matrix organization (GO:1903055)3.51130206
33skin morphogenesis (GO:0043589)3.48900252
34positive regulation of heat generation (GO:0031652)3.47940172
35L-alpha-amino acid transmembrane transport (GO:1902475)3.44787061
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37714432
37response to host (GO:0075136)3.37714432
38response to host defenses (GO:0052200)3.37714432
39glial cell migration (GO:0008347)3.32682873
40cell adhesion mediated by integrin (GO:0033627)3.30850853
41negative regulation of lipid storage (GO:0010888)3.30547270
42positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.30112156
43reactive oxygen species biosynthetic process (GO:1903409)3.24868061
44negative regulation of interleukin-1 beta production (GO:0032691)3.21219966
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21179748
46regulation of early endosome to late endosome transport (GO:2000641)3.19887250
47mannose metabolic process (GO:0006013)3.19168555
48ceramide catabolic process (GO:0046514)3.16428082
49protein heterotrimerization (GO:0070208)3.15872183
50hyaluronan catabolic process (GO:0030214)3.15185338
51response to muramyl dipeptide (GO:0032495)3.14819021
52microglial cell activation (GO:0001774)3.14586831
53cell migration involved in heart development (GO:0060973)3.12500821
54modulation by symbiont of host cellular process (GO:0044068)3.12288215
55response to thyroid hormone (GO:0097066)3.11140755
56detection of molecule of bacterial origin (GO:0032490)3.10529417
57positive regulation of interferon-alpha production (GO:0032727)3.10518460
58apoptotic cell clearance (GO:0043277)3.10313469
59plasma lipoprotein particle clearance (GO:0034381)3.09763432
60positive regulation of chemokine biosynthetic process (GO:0045080)3.09337348
61decidualization (GO:0046697)3.07992298
62lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06491402
63regulation of macrophage chemotaxis (GO:0010758)3.06353650
64stress fiber assembly (GO:0043149)3.05467856
65collagen metabolic process (GO:0032963)3.03834187
66membrane lipid catabolic process (GO:0046466)3.02731473
67collagen catabolic process (GO:0030574)3.02632354
68regulation of interferon-alpha production (GO:0032647)3.00325565
69macrophage activation (GO:0042116)3.00171184
70respiratory burst (GO:0045730)2.98394019
71keratan sulfate catabolic process (GO:0042340)2.97900764
72negative regulation of smooth muscle cell migration (GO:0014912)2.97260792
73regulation of extracellular matrix disassembly (GO:0010715)2.94535802
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.92868700
75pinocytosis (GO:0006907)2.92730766
76positive regulation of p38MAPK cascade (GO:1900745)2.90870160
77regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90581242
78sphingolipid catabolic process (GO:0030149)2.89356033
79modification by symbiont of host morphology or physiology (GO:0044003)2.87981937
80basic amino acid transport (GO:0015802)2.87645362
81basement membrane organization (GO:0071711)2.85900578
82response to magnesium ion (GO:0032026)2.83454893
83multicellular organismal macromolecule metabolic process (GO:0044259)2.82098401
84venous blood vessel morphogenesis (GO:0048845)2.81543693
85multicellular organismal catabolic process (GO:0044243)2.81074562
86positive regulation of lipid storage (GO:0010884)2.80742206
87negative regulation of nitric oxide biosynthetic process (GO:0045019)2.78038561
88phagosome maturation (GO:0090382)2.77182350
89neutrophil mediated immunity (GO:0002446)2.76005376
90dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75449985
91regulation of mononuclear cell migration (GO:0071675)2.75056981
92negative regulation of interleukin-1 production (GO:0032692)2.73958878
93substrate-dependent cell migration (GO:0006929)2.73943231
94positive regulation of receptor recycling (GO:0001921)2.71048150
95adenosine receptor signaling pathway (GO:0001973)2.68623947
96regulation of vitamin D biosynthetic process (GO:0060556)2.68273805
97protein retention in ER lumen (GO:0006621)2.67637963
98phospholipid homeostasis (GO:0055091)2.67508193
99regulation of heat generation (GO:0031650)2.67477859
100regulation of monocyte chemotaxis (GO:0090025)2.67395933
101extracellular matrix disassembly (GO:0022617)2.67144334
102positive regulation of cholesterol efflux (GO:0010875)2.66627594
103negative regulation of interleukin-12 production (GO:0032695)2.66124726
104myeloid cell activation involved in immune response (GO:0002275)2.65713654
105positive regulation of gamma-delta T cell activation (GO:0046645)2.65684839
106embryo implantation (GO:0007566)2.65295474
107multicellular organismal metabolic process (GO:0044236)2.64537776
108regulation of fever generation (GO:0031620)2.63762598
109negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.63430762
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63236483
111detection of biotic stimulus (GO:0009595)2.62026142
112regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61359738
113regulation of lipid storage (GO:0010883)2.60984967
114chondroitin sulfate catabolic process (GO:0030207)2.60803647
115lipoprotein transport (GO:0042953)2.58604641
116peptidyl-glutamic acid carboxylation (GO:0017187)2.58559172
117protein carboxylation (GO:0018214)2.58559172
118regulation of extracellular matrix organization (GO:1903053)2.57867274
119wound healing, spreading of epidermal cells (GO:0035313)2.57500833
120regulation of cellular amide metabolic process (GO:0034248)2.56802304
121natural killer cell mediated immunity (GO:0002228)2.55816921
122natural killer cell mediated cytotoxicity (GO:0042267)2.55816921
123negative regulation of interleukin-17 production (GO:0032700)2.54234552
124semaphorin-plexin signaling pathway (GO:0071526)2.53510251
125response to acidic pH (GO:0010447)2.52922792
126positive regulation of interleukin-1 beta secretion (GO:0050718)2.51650202
127cortical actin cytoskeleton organization (GO:0030866)2.51201137
128type B pancreatic cell proliferation (GO:0044342)2.48668584
129granulocyte activation (GO:0036230)2.47754644
130regulation of integrin activation (GO:0033623)2.47754063
131response to lipoprotein particle (GO:0055094)2.46943631
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46637788
133positive regulation of endothelial cell apoptotic process (GO:2000353)2.46358069
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.46236942
135positive regulation of axon extension (GO:0045773)2.45814683
136endothelial cell chemotaxis (GO:0035767)2.44958044
137cell-cell junction maintenance (GO:0045217)2.42861389
138positive regulation of antigen processing and presentation (GO:0002579)2.41630714
139positive regulation of leukocyte degranulation (GO:0043302)2.41585155
140chondroitin sulfate biosynthetic process (GO:0030206)2.41522419
141regulation of smooth muscle cell migration (GO:0014910)2.40969232
142positive regulation of monocyte chemotaxis (GO:0090026)2.40933392
143cytokine secretion (GO:0050663)2.40919707
144eosinophil chemotaxis (GO:0048245)2.40336664
145Golgi transport vesicle coating (GO:0048200)2.39089497
146COPI coating of Golgi vesicle (GO:0048205)2.39089497
147regulation of heterotypic cell-cell adhesion (GO:0034114)2.38811611
148epithelial cell-cell adhesion (GO:0090136)2.38673944
149superoxide anion generation (GO:0042554)2.38434754
150vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.38236151
151collagen fibril organization (GO:0030199)2.37142435
152positive regulation of fat cell differentiation (GO:0045600)2.37010255
153negative regulation of erythrocyte differentiation (GO:0045647)2.36959300
154regulation of macrophage derived foam cell differentiation (GO:0010743)2.36676861
155cortical cytoskeleton organization (GO:0030865)2.36251183
156vascular endothelial growth factor signaling pathway (GO:0038084)2.34619177
157positive regulation of phagocytosis (GO:0050766)2.34281292
158positive regulation of interleukin-1 secretion (GO:0050716)2.34278816
159regulation of apoptotic cell clearance (GO:2000425)2.33830069
160endocytic recycling (GO:0032456)2.33749688
161negative regulation of focal adhesion assembly (GO:0051895)2.33688909
162negative regulation of cell junction assembly (GO:1901889)2.33688909
163negative regulation of adherens junction organization (GO:1903392)2.33688909
164fibril organization (GO:0097435)2.32947408
165chondrocyte proliferation (GO:0035988)2.32923977
166response to laminar fluid shear stress (GO:0034616)2.31539368
167regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31456654
168fat-soluble vitamin biosynthetic process (GO:0042362)2.30702854
169angiotensin maturation (GO:0002003)2.29893428
170triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.29555240
171regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29202783
172positive regulation of triglyceride lipase activity (GO:0061365)2.28574353
173positive regulation of lipoprotein lipase activity (GO:0051006)2.28574353
174positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.28331129
175regulation of interleukin-1 beta secretion (GO:0050706)2.28308704
176regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26655093
177complement activation, alternative pathway (GO:0006957)2.26551870
178positive regulation of smooth muscle cell migration (GO:0014911)2.25917431
179positive regulation of interferon-beta production (GO:0032728)2.25207581
180alpha-linolenic acid metabolic process (GO:0036109)2.24668461
181positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23477195
182regulation of chemokine biosynthetic process (GO:0045073)2.19319082
183interaction with host (GO:0051701)2.19174719
184intracellular pH reduction (GO:0051452)2.18958507
185cellular response to nicotine (GO:0071316)2.18707905
186erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.18139505
187L-phenylalanine catabolic process (GO:0006559)2.18139505
188regulation of cholesterol homeostasis (GO:2000188)2.18059602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.47876724
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.37054765
3Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.88118797
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.53320753
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34688734
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.19399924
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.07188731
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.99964164
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86688567
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.73746139
11* LXR_22158963_ChIP-Seq_LIVER_Mouse2.66317633
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41654777
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32790416
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29478818
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.25190887
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16349551
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04896343
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92185540
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84762754
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84303081
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79818790
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79755380
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78983981
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78672098
25* VDR_21846776_ChIP-Seq_THP-1_Human1.74497285
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67691226
27RACK7_27058665_Chip-Seq_MCF-7_Human1.67611735
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66849094
29SPI1_23127762_ChIP-Seq_K562_Human1.64889540
30* VDR_24787735_ChIP-Seq_THP-1_Human1.63916753
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.63349747
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62136951
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.61848549
34GATA1_22025678_ChIP-Seq_K562_Human1.60048547
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58725337
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57259270
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54453590
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.53759840
39KDM2B_26808549_Chip-Seq_DND41_Human1.51855400
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51246642
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50544387
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50425317
43* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50290640
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47186533
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.46759556
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44811079
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42905092
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42697870
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41124358
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38653856
51* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37960788
52* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34772368
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33966689
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33719057
55SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32451694
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32100738
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31135207
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29721946
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29353802
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28047285
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27697627
62TP53_22127205_ChIP-Seq_IMR90_Human1.26981481
63PU_27001747_Chip-Seq_BMDM_Mouse1.26697284
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26660438
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26660438
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24702745
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23339674
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.22690078
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21140827
70TCF7_22412390_ChIP-Seq_EML_Mouse1.20991437
71SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17908308
72* VDR_24763502_ChIP-Seq_THP-1_Human1.17005761
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.16958452
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16140071
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15917072
76ZNF263_19887448_ChIP-Seq_K562_Human1.15470463
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.15184475
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14760272
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14500983
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13935601
81* LXR_22292898_ChIP-Seq_THP-1_Human1.13467439
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13414409
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12494956
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12054474
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10397863
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10041924
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09431251
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.09366972
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09032700
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08016828
91GATA1_19941826_ChIP-Seq_K562_Human1.07750228
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07436608
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.05920090
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.05318533
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05113669
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04928704
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03933544
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.02943188
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.02943188
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.02744453
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01202114
102CLOCK_20551151_ChIP-Seq_293T_Human1.00017037
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99780850
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98854717
105* TET1_21451524_ChIP-Seq_MESCs_Mouse0.97993144
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.97127509
107SOX2_20726797_ChIP-Seq_SW620_Human0.96589833
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94572262
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94261765
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93111926
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92492909
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92192162
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91686096
114* TP53_23651856_ChIP-Seq_MEFs_Mouse0.91588250
115MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91459553
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91381113
117* SMC4_20622854_ChIP-Seq_HELA_Human0.90808416
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88562524
119* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88350625
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.88043080
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88022408
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87855092
123SCL_19346495_ChIP-Seq_HPC-7_Human0.87538206
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85679410
125GATA2_19941826_ChIP-Seq_K562_Human0.84538083
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83423414
127* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82544597
128GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81055657
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79925162
130SPI1_23547873_ChIP-Seq_NB4_Human0.77436047
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77376764
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76714263
133RUNX1_22412390_ChIP-Seq_EML_Mouse0.76498550
134ELK3_25401928_ChIP-Seq_HUVEC_Human0.75838805
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75316822
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.75154110
137CJUN_26792858_Chip-Seq_BT549_Human0.74321439
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73936390
139SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71707453
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71408870
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69412071
142* KDM2B_26808549_Chip-Seq_K562_Human0.69097820
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69004962
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68771265
145GATA3_26560356_Chip-Seq_TH2_Human0.68223951
146STAT4_19710469_ChIP-ChIP_TH1__Mouse0.64971785
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64713253
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.64082225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.44286366
2MP0000569_abnormal_digit_pigmentation4.28248109
3MP0003172_abnormal_lysosome_physiology3.69473058
4MP0003303_peritoneal_inflammation3.31771096
5MP0003279_aneurysm3.01208810
6MP0009840_abnormal_foam_cell2.93475611
7MP0002139_abnormal_hepatobiliary_system2.92256353
8MP0003195_calcinosis2.84731741
9MP0003183_abnormal_peptide_metabolism2.80460356
10MP0003436_decreased_susceptibility_to2.79440779
11MP0005083_abnormal_biliary_tract2.44988975
12MP0005257_abnormal_intraocular_pressure2.42962928
13MP0000604_amyloidosis2.36520611
14MP0002419_abnormal_innate_immunity2.33378293
15MP0005360_urolithiasis2.30151179
16MP0006054_spinal_hemorrhage2.22576031
17MP0001835_abnormal_antigen_presentation2.16596136
18MP0006082_CNS_inflammation2.15881213
19MP0005503_abnormal_tendon_morphology2.08764287
20MP0004510_myositis2.08220886
21MP0009278_abnormal_bone_marrow2.04095186
22MP0001542_abnormal_bone_strength2.03719379
23MP0005365_abnormal_bile_salt1.97482303
24MP0003300_gastrointestinal_ulcer1.96356697
25MP0003191_abnormal_cellular_cholesterol1.94560517
26MP0004272_abnormal_basement_membrane1.93003274
27MP0009785_altered_susceptibility_to1.80203246
28MP0005387_immune_system_phenotype1.74407092
29MP0001790_abnormal_immune_system1.74407092
30MP0004947_skin_inflammation1.73246210
31MP0005000_abnormal_immune_tolerance1.73056313
32MP0005464_abnormal_platelet_physiology1.71777663
33MP0005023_abnormal_wound_healing1.71024784
34MP0001849_ear_inflammation1.68531559
35MP0005025_abnormal_response_to1.68454104
36MP0005275_abnormal_skin_tensile1.68378014
37MP0004858_abnormal_nervous_system1.67562504
38MP0010386_abnormal_urinary_bladder1.67379526
39MP0003690_abnormal_glial_cell1.63554680
40MP0001533_abnormal_skeleton_physiology1.61677970
41MP0002896_abnormal_bone_mineralization1.60122169
42MP0003075_altered_response_to1.59747463
43MP0002877_abnormal_melanocyte_morpholog1.55921030
44MP0002148_abnormal_hypersensitivity_rea1.54017302
45MP0005167_abnormal_blood-brain_barrier1.53982614
46MP0002909_abnormal_adrenal_gland1.51896751
47MP0003724_increased_susceptibility_to1.51055647
48MP0000767_abnormal_smooth_muscle1.49023244
49MP0000751_myopathy1.44012240
50MP0002138_abnormal_hepatobiliary_system1.42760724
51MP0005451_abnormal_body_composition1.42574466
52MP0002254_reproductive_system_inflammat1.41791913
53MP0005595_abnormal_vascular_smooth1.39585448
54MP0008469_abnormal_protein_level1.39504951
55MP0002998_abnormal_bone_remodeling1.39004567
56MP0005508_abnormal_skeleton_morphology1.38153251
57MP0010329_abnormal_lipoprotein_level1.35402526
58MP0002452_abnormal_antigen_presenting1.33968891
59MP0003453_abnormal_keratinocyte_physiol1.33063343
60MP0000920_abnormal_myelination1.32689945
61MP0002693_abnormal_pancreas_physiology1.31396642
62MP0005390_skeleton_phenotype1.31156695
63MP0005085_abnormal_gallbladder_physiolo1.29608714
64MP0000858_altered_metastatic_potential1.28779677
65MP0009764_decreased_sensitivity_to1.28306210
66MP0001845_abnormal_inflammatory_respons1.25930831
67MP0004130_abnormal_muscle_cell1.25497147
68MP0003252_abnormal_bile_duct1.24395508
69MP0000685_abnormal_immune_system1.24256617
70MP0003705_abnormal_hypodermis_morpholog1.23801285
71MP0008961_abnormal_basal_metabolism1.22379690
72MP0002723_abnormal_immune_serum1.21837428
73MP0009384_cardiac_valve_regurgitation1.21373948
74MP0000609_abnormal_liver_physiology1.17400705
75MP0005174_abnormal_tail_pigmentation1.16772137
76MP0003448_altered_tumor_morphology1.15255978
77MP0002118_abnormal_lipid_homeostasis1.14882915
78MP0008875_abnormal_xenobiotic_pharmacok1.12392472
79MP0002295_abnormal_pulmonary_circulatio1.09300855
80MP0008260_abnormal_autophagy1.09162012
81MP0000371_diluted_coat_color1.08416174
82MP0005332_abnormal_amino_acid1.07900328
83MP0001800_abnormal_humoral_immune1.05495107
84MP0001243_abnormal_dermal_layer1.05411854
85MP0003656_abnormal_erythrocyte_physiolo1.05382297
86MP0002078_abnormal_glucose_homeostasis1.05000669
87MP0005165_increased_susceptibility_to1.04818006
88MP0001853_heart_inflammation1.03973739
89MP0001756_abnormal_urination1.02194000
90MP0002933_joint_inflammation1.02091895
91MP0005166_decreased_susceptibility_to1.02009622
92MP0009780_abnormal_chondrocyte_physiolo1.01004345
93MP0002060_abnormal_skin_morphology1.00132822
94MP0009763_increased_sensitivity_to0.99213996
95MP0009643_abnormal_urine_homeostasis0.96912301
96MP0005076_abnormal_cell_differentiation0.96899566
97MP0000343_altered_response_to0.95873140
98MP0005535_abnormal_body_temperature0.94437719
99MP0003566_abnormal_cell_adhesion0.93893632
100MP0003828_pulmonary_edema0.93632780
101MP0003329_amyloid_beta_deposits0.92024424
102MP0001819_abnormal_immune_cell0.91883907
103MP0005319_abnormal_enzyme/_coenzyme0.89039745
104MP0002420_abnormal_adaptive_immunity0.88341728
105MP0004019_abnormal_vitamin_homeostasis0.88321738
106MP0004883_abnormal_blood_vessel0.86111879
107MP0000750_abnormal_muscle_regeneration0.86060625
108MP0005448_abnormal_energy_balance0.85124144
109MP0001958_emphysema0.85026711
110MP0001881_abnormal_mammary_gland0.83978635
111MP0000747_muscle_weakness0.83142489
112MP0003634_abnormal_glial_cell0.82914589
113MP0004043_abnormal_pH_regulation0.81640991
114MP0010368_abnormal_lymphatic_system0.80667179
115MP0008438_abnormal_cutaneous_collagen0.79870035
116MP0001915_intracranial_hemorrhage0.78643359
117MP0003091_abnormal_cell_migration0.78447948
118MP0002405_respiratory_system_inflammati0.77841282
119MP0002090_abnormal_vision0.77759381
120MP0005197_abnormal_uvea_morphology0.77482026
121MP0005310_abnormal_salivary_gland0.76667174
122MP0000249_abnormal_blood_vessel0.76342807
123MP0003950_abnormal_plasma_membrane0.75006300
124MP0002113_abnormal_skeleton_development0.74391363
125MP0005584_abnormal_enzyme/coenzyme_acti0.74061817
126MP0001545_abnormal_hematopoietic_system0.72797101
127MP0005397_hematopoietic_system_phenotyp0.72797101
128MP0001944_abnormal_pancreas_morphology0.72030824
129MP0005164_abnormal_response_to0.71668791
130MP0003283_abnormal_digestive_organ0.71089465
131MP0008004_abnormal_stomach_pH0.71042282
132MP0009642_abnormal_blood_homeostasis0.70122750
133MP0002136_abnormal_kidney_physiology0.69908948
134MP0000733_abnormal_muscle_development0.69885684
135MP0002928_abnormal_bile_duct0.69843967
136MP0003879_abnormal_hair_cell0.69383934
137MP0003795_abnormal_bone_structure0.68440821
138MP0002168_other_aberrant_phenotype0.68434324
139MP0008874_decreased_physiological_sensi0.68090443
140MP0000681_abnormal_thyroid_gland0.64844257
141MP0002089_abnormal_postnatal_growth/wei0.63088061
142MP0000163_abnormal_cartilage_morphology0.62983539
143MP0004233_abnormal_muscle_weight0.62912730
144MP0005623_abnormal_meninges_morphology0.61307513
145MP0002115_abnormal_skeleton_extremities0.59558669
146MP0009053_abnormal_anal_canal0.57158979

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)5.26468600
2Increased cerebral lipofuscin (HP:0011813)5.11285671
3Vacuolated lymphocytes (HP:0001922)4.95902218
4Premature rupture of membranes (HP:0001788)4.88126495
5Recurrent abscess formation (HP:0002722)4.85224590
6Recurrent bacterial skin infections (HP:0005406)4.73115671
7Protrusio acetabuli (HP:0003179)4.47552042
8Eczematoid dermatitis (HP:0000976)4.31572208
9Dysostosis multiplex (HP:0000943)4.28329196
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.20244019
11Stomatitis (HP:0010280)4.02473719
12Urinary glycosaminoglycan excretion (HP:0003541)4.00905593
13Mucopolysacchariduria (HP:0008155)4.00905593
14Abnormality of polysaccharide metabolism (HP:0011012)3.92218645
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.92218645
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.92218645
17Abnormality of macrophages (HP:0004311)3.89426605
18Axonal loss (HP:0003447)3.85882169
19Abnormality of glycolipid metabolism (HP:0010969)3.73577096
20Abnormality of liposaccharide metabolism (HP:0010968)3.73577096
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.73577096
22Amyloidosis (HP:0011034)3.64038725
23Gingivitis (HP:0000230)3.51146581
24Systemic lupus erythematosus (HP:0002725)3.47636031
25Elevated erythrocyte sedimentation rate (HP:0003565)3.41010511
26Ankle contracture (HP:0006466)3.32986145
27Nuclear cataract (HP:0100018)3.27148682
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07322277
29Mediastinal lymphadenopathy (HP:0100721)3.01660297
30Cerebral aneurysm (HP:0004944)3.01614456
31Joint hemorrhage (HP:0005261)3.00071075
32Glomerulonephritis (HP:0000099)2.96052274
33Autoimmune thrombocytopenia (HP:0001973)2.93365100
34Myocardial infarction (HP:0001658)2.91857856
35Cervical subluxation (HP:0003308)2.88533334
36Cerebral inclusion bodies (HP:0100314)2.86718883
37Recurrent skin infections (HP:0001581)2.77086169
38Xanthomatosis (HP:0000991)2.77024681
39Type 1 muscle fiber predominance (HP:0003803)2.76714157
40Spinal rigidity (HP:0003306)2.76234658
41Bladder diverticulum (HP:0000015)2.74393527
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.71591889
43Vascular tortuosity (HP:0004948)2.67924621
44Global brain atrophy (HP:0002283)2.67580959
45Achilles tendon contracture (HP:0001771)2.67331892
46Complement deficiency (HP:0004431)2.67049238
47Atrophic scars (HP:0001075)2.62376021
48Pathologic fracture (HP:0002756)2.62273196
49Retinal atrophy (HP:0001105)2.61005141
50Slender build (HP:0001533)2.59848290
51Tetraparesis (HP:0002273)2.59753020
52Mutism (HP:0002300)2.58550164
53Aortic dissection (HP:0002647)2.56548129
54Loss of speech (HP:0002371)2.56518052
55Spondylolisthesis (HP:0003302)2.54888578
56Periodontitis (HP:0000704)2.54164683
57Hypoglycemic seizures (HP:0002173)2.50915634
58Follicular hyperkeratosis (HP:0007502)2.48477362
59Thick nail (HP:0001805)2.46662282
60Aortic aneurysm (HP:0004942)2.45838911
61Abnormality of the Achilles tendon (HP:0005109)2.44553449
62Peripheral demyelination (HP:0011096)2.39682734
63Disinhibition (HP:0000734)2.38323795
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37907346
65Arterial tortuosity (HP:0005116)2.35586017
66Increased CSF protein (HP:0002922)2.33088550
67Genu recurvatum (HP:0002816)2.32671555
68Bone pain (HP:0002653)2.32554527
69Increased variability in muscle fiber diameter (HP:0003557)2.32454770
70Hypoglycemic coma (HP:0001325)2.32364676
71Skin nodule (HP:0200036)2.32162995
72Joint stiffness (HP:0001387)2.31125739
73Premature loss of primary teeth (HP:0006323)2.29714447
74Abnormality of the common coagulation pathway (HP:0010990)2.29007833
75Fragile skin (HP:0001030)2.28222508
76Urticaria (HP:0001025)2.28186718
77Abnormality of complement system (HP:0005339)2.27902266
78Shallow orbits (HP:0000586)2.27385682
79Frequent falls (HP:0002359)2.27353499
80Distal upper limb amyotrophy (HP:0007149)2.25443245
81Upper limb amyotrophy (HP:0009129)2.25443245
82Hyperacusis (HP:0010780)2.24234903
83Wormian bones (HP:0002645)2.23770202
84Apathy (HP:0000741)2.23428948
85Increased connective tissue (HP:0009025)2.23094718
86Blue sclerae (HP:0000592)2.22843349
87Thin bony cortex (HP:0002753)2.21875508
88Orchitis (HP:0100796)2.21364082
89Hypercholesterolemia (HP:0003124)2.21017742
90Broad metatarsal (HP:0001783)2.20957664
91Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20342171
92J-shaped sella turcica (HP:0002680)2.19586876
93Hydroxyprolinuria (HP:0003080)2.18372549
94Abnormality of proline metabolism (HP:0010907)2.18372549
95Supranuclear gaze palsy (HP:0000605)2.17624798
96Ketoacidosis (HP:0001993)2.16369679
97Diminished motivation (HP:0000745)2.16219151
98Soft skin (HP:0000977)2.15998704
99Protuberant abdomen (HP:0001538)2.15402767
100Deep venous thrombosis (HP:0002625)2.14898002
101Upper motor neuron abnormality (HP:0002127)2.12642373
102Episodic fever (HP:0001954)2.12067165
103Abnormality of purine metabolism (HP:0004352)2.11690669
104Prolonged partial thromboplastin time (HP:0003645)2.10291965
105Abnormality of dentin (HP:0010299)2.08014874
106Nephritis (HP:0000123)2.07559191
107Hyperinsulinemic hypoglycemia (HP:0000825)2.06856802
108Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05020508
109Mitral stenosis (HP:0001718)2.05004577
110Purpura (HP:0000979)2.04798904
111Dilatation of the ascending aorta (HP:0005111)2.04275607
112* Hypophosphatemia (HP:0002148)2.04034125
113Epidermoid cyst (HP:0200040)2.03685246
114Gingival bleeding (HP:0000225)2.03453123
115Ovoid vertebral bodies (HP:0003300)2.01487984
116Progressive sensorineural hearing impairment (HP:0000408)2.00628328
117Aneurysm (HP:0002617)1.99984947
118Abnormality of skeletal muscle fiber size (HP:0012084)1.97732556
119Symptomatic seizures (HP:0011145)1.97317477
120Mitral regurgitation (HP:0001653)1.96925298
121Conjugated hyperbilirubinemia (HP:0002908)1.96654057
122Mildly elevated creatine phosphokinase (HP:0008180)1.96413616
123Vertebral compression fractures (HP:0002953)1.95637920
124Asymmetric septal hypertrophy (HP:0001670)1.95478710
125Vasculitis (HP:0002633)1.94823954
126Osteolytic defects of the hand bones (HP:0009699)1.94789863
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.94789863
128Optic neuritis (HP:0100653)1.94665820
129Retrobulbar optic neuritis (HP:0100654)1.94665820
130Hyperlipoproteinemia (HP:0010980)1.94474563
131Distal lower limb muscle weakness (HP:0009053)1.93692743
132Peritonitis (HP:0002586)1.93056941
133Neuronal loss in central nervous system (HP:0002529)1.92400150
134Generalized amyotrophy (HP:0003700)1.91360159
135Abnormality of the intrinsic pathway (HP:0010989)1.91015157
136Ketosis (HP:0001946)1.90323406
137Elbow flexion contracture (HP:0002987)1.89982200
138Obstructive sleep apnea (HP:0002870)1.89696065
139Progressive hearing impairment (HP:0001730)1.88204174
140Hematochezia (HP:0002573)1.88007596
141Myositis (HP:0100614)1.87286124
142Abdominal distention (HP:0003270)1.86553008
143Bowel diverticulosis (HP:0005222)1.86305171
144Abnormality of vision evoked potentials (HP:0000649)1.85643648
145Basal ganglia calcification (HP:0002135)1.85267778
146Neonatal short-limb short stature (HP:0008921)1.84955562
147Hand muscle atrophy (HP:0009130)1.84882420
148Recurrent fungal infections (HP:0002841)1.84427850
149Hyperglycemia (HP:0003074)1.82382443
150Short nail (HP:0001799)1.82092643
151Slow saccadic eye movements (HP:0000514)1.81719204
152Thoracic kyphosis (HP:0002942)1.81146463
153Distal lower limb amyotrophy (HP:0008944)1.80656428
154Menorrhagia (HP:0000132)1.80356431
155Neurofibrillary tangles (HP:0002185)1.79195477
156Prolonged neonatal jaundice (HP:0006579)1.78237972
157Intrahepatic cholestasis (HP:0001406)1.77307844
158Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76947745
159Biconcave vertebral bodies (HP:0004586)1.76863771
160Pulmonary infiltrates (HP:0002113)1.76085217
161Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75760289
162Progressive neurologic deterioration (HP:0002344)1.74880830
163Hyperextensible skin (HP:0000974)1.74866685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.75130478
2IRAK33.68177501
3ERN13.44429942
4DDR23.33868860
5MAP3K143.29957282
6TGFBR22.94931175
7DAPK22.93693082
8NME22.89560368
9TBK12.87790439
10TAOK32.79643268
11INSRR2.56508203
12TYK22.30086622
13TESK12.29772175
14EPHB22.06936742
15IKBKE2.03107657
16LIMK12.01604543
17CDC42BPA1.96149710
18SIK11.95461049
19IRAK41.94368642
20GRK71.91732399
21TRIB31.83961302
22LATS21.83596200
23JAK11.82509983
24MAP3K131.74362383
25KIT1.73048368
26PRPF4B1.70332800
27TAOK21.68904663
28PTK61.66770766
29BLK1.65072548
30MOS1.65060681
31CAMK1D1.58854608
32MAPK151.58189342
33RIPK11.56563390
34MYLK1.55205296
35SIK21.54736389
36ICK1.49827079
37CAMK1G1.45724871
38PAK41.42173190
39PIM21.39395144
40JAK31.38586062
41MAP3K111.36601353
42MAP3K21.30541135
43IKBKB1.28364904
44MAP2K31.27651964
45MST1R1.25634258
46PRKD21.22715852
47ARAF1.21950030
48JAK21.18866385
49WNK31.17946109
50CSK1.16881263
51TTN1.16765458
52CHUK1.15635434
53PAK21.12275167
54TYRO31.06553970
55FGFR41.05540817
56TAOK11.00474014
57HCK0.97376863
58MAP3K30.95476380
59FGR0.95185704
60ERBB40.93599228
61ZAP700.93557206
62FES0.90354553
63MAP3K60.90336011
64KSR20.89974134
65ABL20.89238711
66DAPK30.87385109
67DAPK10.87035080
68NTRK10.86773150
69TESK20.84764399
70CAMKK20.83558224
71EGFR0.81692915
72SYK0.80899967
73MAP3K10.80757499
74HIPK20.79411098
75BMX0.75519621
76MATK0.75064745
77EPHB10.74446149
78MAPK70.73726159
79MAP3K90.71834953
80PIK3CG0.69497237
81CAMKK10.69400998
82PINK10.68651510
83MARK20.68134402
84SMG10.66340513
85PDGFRB0.66191251
86MAP3K100.65925193
87PTK20.65825733
88SCYL20.65732203
89ROCK20.64493986
90PRKCH0.63731800
91DMPK0.61481812
92CSF1R0.60919081
93PDPK10.60802712
94PKN20.60757423
95CAMK2G0.60255026
96PDGFRA0.58498045
97LYN0.57563084
98LCK0.57044855
99SIK30.56794806
100RPS6KA60.56663492
101MAPK40.56481628
102RPS6KA20.56217290
103TXK0.56067193
104DYRK1B0.55134192
105RPS6KC10.54724813
106RPS6KL10.54724813
107MAP4K10.54532924
108ADRBK20.54205326
109ERBB20.52257536
110FYN0.51725961
111GSK3A0.51275351
112PRKCD0.50769819
113ROCK10.49979732
114MARK30.49813609
115SGK10.48854842
116ABL10.48202420
117IRAK20.48183838
118LMTK20.46775967
119NEK90.46573510
120RPS6KA40.46024875
121STK380.45939510
122TGFBR10.45053313
123MAPK120.44807151
124SGK30.44687127
125FGFR30.44428800
126BRAF0.44286962
127MTOR0.43669521
128MAP3K50.40885124
129BCKDK0.40060462
130IGF1R0.39306116
131MARK10.39297584
132FRK0.38895365
133IRAK10.38410279
134CDK60.37906009
135PRKCZ0.37608708
136RET0.37513990
137PRKCE0.37164124
138PAK10.37137318
139MET0.36845765
140SRC0.36712269
141CDK150.36628622
142PRKD30.36342898
143PRKD10.36299191
144CAMK2B0.36284313
145PRKG20.34588941
146PAK60.34017684
147MAP3K80.33825721
148CDK11A0.32821724

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.90020697
2Lysosome_Homo sapiens_hsa041422.74410378
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.37860197
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.28580731
5Leishmaniasis_Homo sapiens_hsa051402.11986699
6Caffeine metabolism_Homo sapiens_hsa002322.00309389
7Type II diabetes mellitus_Homo sapiens_hsa049301.92943009
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86679940
9Pertussis_Homo sapiens_hsa051331.79423041
10Phagosome_Homo sapiens_hsa041451.78171093
11Osteoclast differentiation_Homo sapiens_hsa043801.76502244
12Complement and coagulation cascades_Homo sapiens_hsa046101.73123321
13Rheumatoid arthritis_Homo sapiens_hsa053231.68582744
14Other glycan degradation_Homo sapiens_hsa005111.67424651
15Tuberculosis_Homo sapiens_hsa051521.66920223
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.66853979
17Collecting duct acid secretion_Homo sapiens_hsa049661.62974085
18Bladder cancer_Homo sapiens_hsa052191.60488038
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60235434
20ECM-receptor interaction_Homo sapiens_hsa045121.60022716
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54241030
22Malaria_Homo sapiens_hsa051441.45348891
23Legionellosis_Homo sapiens_hsa051341.42188823
24Arginine biosynthesis_Homo sapiens_hsa002201.33985217
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.32400979
26Focal adhesion_Homo sapiens_hsa045101.32298219
27TNF signaling pathway_Homo sapiens_hsa046681.31008428
28Nitrogen metabolism_Homo sapiens_hsa009101.24267242
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20490192
30Type I diabetes mellitus_Homo sapiens_hsa049401.19094730
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18915098
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11830968
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.11384581
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09037579
35PPAR signaling pathway_Homo sapiens_hsa033201.06616423
36Insulin resistance_Homo sapiens_hsa049311.03061719
37Proteoglycans in cancer_Homo sapiens_hsa052051.00628936
38Influenza A_Homo sapiens_hsa051641.00051835
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99536390
40Mineral absorption_Homo sapiens_hsa049780.99041381
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97277697
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95185174
43B cell receptor signaling pathway_Homo sapiens_hsa046620.95036159
44Protein digestion and absorption_Homo sapiens_hsa049740.94386089
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94276001
46Vibrio cholerae infection_Homo sapiens_hsa051100.94243746
47Prion diseases_Homo sapiens_hsa050200.92307228
48Tryptophan metabolism_Homo sapiens_hsa003800.91297363
49Synaptic vesicle cycle_Homo sapiens_hsa047210.91205719
50ABC transporters_Homo sapiens_hsa020100.91072645
51Graft-versus-host disease_Homo sapiens_hsa053320.90853281
52Amoebiasis_Homo sapiens_hsa051460.87758758
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87682565
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85884124
55African trypanosomiasis_Homo sapiens_hsa051430.84345196
56Notch signaling pathway_Homo sapiens_hsa043300.81735175
57Toxoplasmosis_Homo sapiens_hsa051450.80431218
58Sulfur metabolism_Homo sapiens_hsa009200.80071587
59Hepatitis C_Homo sapiens_hsa051600.79727349
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79685287
61Asthma_Homo sapiens_hsa053100.79675102
62VEGF signaling pathway_Homo sapiens_hsa043700.79626622
63Starch and sucrose metabolism_Homo sapiens_hsa005000.78662216
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78580675
65Fatty acid degradation_Homo sapiens_hsa000710.76458119
66Fructose and mannose metabolism_Homo sapiens_hsa000510.76031092
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75463004
68Apoptosis_Homo sapiens_hsa042100.75271758
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74893492
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.73740104
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.73615508
72Peroxisome_Homo sapiens_hsa041460.73424931
73Measles_Homo sapiens_hsa051620.73390597
74Bile secretion_Homo sapiens_hsa049760.73020553
75Dilated cardiomyopathy_Homo sapiens_hsa054140.71453311
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.71217128
77Renin-angiotensin system_Homo sapiens_hsa046140.70532319
78GnRH signaling pathway_Homo sapiens_hsa049120.68530220
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.68180601
80Prolactin signaling pathway_Homo sapiens_hsa049170.66756753
81Endocytosis_Homo sapiens_hsa041440.65821433
82Selenocompound metabolism_Homo sapiens_hsa004500.65453299
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64530291
84Salmonella infection_Homo sapiens_hsa051320.63457718
85Butanoate metabolism_Homo sapiens_hsa006500.62123984
86Pentose phosphate pathway_Homo sapiens_hsa000300.60831446
87Histidine metabolism_Homo sapiens_hsa003400.60417740
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60058919
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59813178
90Estrogen signaling pathway_Homo sapiens_hsa049150.58878449
91Fatty acid metabolism_Homo sapiens_hsa012120.58416313
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58061693
93Renal cell carcinoma_Homo sapiens_hsa052110.57654070
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56531577
95Chemokine signaling pathway_Homo sapiens_hsa040620.56061254
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56025576
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.54999084
98Steroid biosynthesis_Homo sapiens_hsa001000.53643842
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53171214
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52875332
101Viral myocarditis_Homo sapiens_hsa054160.52843632
102Insulin secretion_Homo sapiens_hsa049110.51429288
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51273018
104Hepatitis B_Homo sapiens_hsa051610.50570306
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49842239
106Chronic myeloid leukemia_Homo sapiens_hsa052200.49820742
107Allograft rejection_Homo sapiens_hsa053300.49349535
108Shigellosis_Homo sapiens_hsa051310.48784544
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48727930
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48581514
111Glioma_Homo sapiens_hsa052140.48552329
112Folate biosynthesis_Homo sapiens_hsa007900.48293147
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47948248
114Pancreatic cancer_Homo sapiens_hsa052120.46279018
115Rap1 signaling pathway_Homo sapiens_hsa040150.45407955
116Fatty acid biosynthesis_Homo sapiens_hsa000610.44238073
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44062827
118Lysine degradation_Homo sapiens_hsa003100.43759521
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43512286
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43079995
121mTOR signaling pathway_Homo sapiens_hsa041500.43044742
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43026731
123Sphingolipid metabolism_Homo sapiens_hsa006000.41345330
124Galactose metabolism_Homo sapiens_hsa000520.41209366
125Antigen processing and presentation_Homo sapiens_hsa046120.40317801
126Gap junction_Homo sapiens_hsa045400.40201001
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40155321
128Vitamin B6 metabolism_Homo sapiens_hsa007500.39679830
129Hematopoietic cell lineage_Homo sapiens_hsa046400.39534087
130HIF-1 signaling pathway_Homo sapiens_hsa040660.39459167
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37612616
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36455822
133Insulin signaling pathway_Homo sapiens_hsa049100.36028061
134Acute myeloid leukemia_Homo sapiens_hsa052210.35896156
135Dorso-ventral axis formation_Homo sapiens_hsa043200.35881427
136beta-Alanine metabolism_Homo sapiens_hsa004100.35603275
137MicroRNAs in cancer_Homo sapiens_hsa052060.35242332
138Phenylalanine metabolism_Homo sapiens_hsa003600.34383411
139Platelet activation_Homo sapiens_hsa046110.34077846
140Fat digestion and absorption_Homo sapiens_hsa049750.33853463
141Small cell lung cancer_Homo sapiens_hsa052220.33430672
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.33429328

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