ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.92785367
2	L-phenylalanine catabolic process (GO:0006559)	6.92785367
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.59381157
4	L-phenylalanine metabolic process (GO:0006558)	6.59381157
5	hemoglobin metabolic process (GO:0020027)	6.32387059
6	aromatic amino acid family catabolic process (GO:0009074)	6.00209956
7	oxygen transport (GO:0015671)	5.91207983
8	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.76826057
9	alpha-linolenic acid metabolic process (GO:0036109)	5.48907479
10	gas transport (GO:0015669)	5.25159636
11	high-density lipoprotein particle remodeling (GO:0034375)	5.22887250
12	indole-containing compound catabolic process (GO:0042436)	5.20673744
13	indolalkylamine catabolic process (GO:0046218)	5.20673744
14	tryptophan catabolic process (GO:0006569)	5.20673744
15	cysteine metabolic process (GO:0006534)	5.20411072
16	bile acid biosynthetic process (GO:0006699)	5.18059270
17	kynurenine metabolic process (GO:0070189)	5.16484269
18	sulfur amino acid catabolic process (GO:0000098)	5.13506126
19	glyoxylate metabolic process (GO:0046487)	5.01443037
20	negative regulation of fibrinolysis (GO:0051918)	5.00265946
21	tryptophan metabolic process (GO:0006568)	4.97780403
22	regulation of fibrinolysis (GO:0051917)	4.90573532
23	urea cycle (GO:0000050)	4.80246475
24	urea metabolic process (GO:0019627)	4.80246475
25	protein carboxylation (GO:0018214)	4.75875821
26	peptidyl-glutamic acid carboxylation (GO:0017187)	4.75875821
27	porphyrin-containing compound biosynthetic process (GO:0006779)	4.72910070
28	reverse cholesterol transport (GO:0043691)	4.72425755
29	lysine catabolic process (GO:0006554)	4.55150087
30	lysine metabolic process (GO:0006553)	4.55150087
31	bile acid metabolic process (GO:0008206)	4.48474595
32	regulation of protein activation cascade (GO:2000257)	4.48055199
33	complement activation, alternative pathway (GO:0006957)	4.44099104
34	regulation of cholesterol esterification (GO:0010872)	4.42476907
35	nitrogen cycle metabolic process (GO:0071941)	4.41426958
36	homocysteine metabolic process (GO:0050667)	4.40106670
37	heme biosynthetic process (GO:0006783)	4.38780626
38	serine family amino acid catabolic process (GO:0009071)	4.38377991
39	plasma lipoprotein particle remodeling (GO:0034369)	4.37254005
40	protein-lipid complex remodeling (GO:0034368)	4.37254005
41	macromolecular complex remodeling (GO:0034367)	4.37254005
42	phospholipid efflux (GO:0033700)	4.36817022
43	tyrosine metabolic process (GO:0006570)	4.36280849
44	aromatic amino acid family metabolic process (GO:0009072)	4.36122916
45	protoporphyrinogen IX metabolic process (GO:0046501)	4.36037374
46	porphyrin-containing compound metabolic process (GO:0006778)	4.35807074
47	negative regulation of cholesterol transport (GO:0032375)	4.30195405
48	negative regulation of sterol transport (GO:0032372)	4.30195405
49	triglyceride homeostasis (GO:0070328)	4.25793514
50	acylglycerol homeostasis (GO:0055090)	4.25793514
51	regulation of triglyceride catabolic process (GO:0010896)	4.24188657
52	cellular ketone body metabolic process (GO:0046950)	4.21521625
53	plasma lipoprotein particle assembly (GO:0034377)	4.18716663
54	cellular modified amino acid catabolic process (GO:0042219)	4.18340752
55	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.18218753
56	regulation of complement activation (GO:0030449)	4.16528490
57	alpha-amino acid catabolic process (GO:1901606)	4.13844035
58	coenzyme catabolic process (GO:0009109)	4.12432427
59	amino-acid betaine metabolic process (GO:0006577)	4.10006132
60	erythrocyte development (GO:0048821)	4.05532457
61	protoporphyrinogen IX biosynthetic process (GO:0006782)	4.04617210
62	tetrapyrrole biosynthetic process (GO:0033014)	4.03500848
63	cholesterol efflux (GO:0033344)	3.97022285
64	regulation of response to osmotic stress (GO:0047484)	3.96240961
65	iron ion import (GO:0097286)	3.95481834
66	heme metabolic process (GO:0042168)	3.95164141
67	indolalkylamine metabolic process (GO:0006586)	3.95030265
68	bile acid and bile salt transport (GO:0015721)	3.93216750
69	cellular amino acid catabolic process (GO:0009063)	3.93137386
70	ethanol oxidation (GO:0006069)	3.92203526
71	intestinal cholesterol absorption (GO:0030299)	3.91538495
72	plasma lipoprotein particle clearance (GO:0034381)	3.86436052
73	glutamate metabolic process (GO:0006536)	3.82443308
74	regulation of cholesterol homeostasis (GO:2000188)	3.82289663
75	very-low-density lipoprotein particle assembly (GO:0034379)	3.77131793
76	glycine metabolic process (GO:0006544)	3.70025561
77	protein-lipid complex assembly (GO:0065005)	3.69556535
78	erythrocyte maturation (GO:0043249)	3.68174854
79	plasma lipoprotein particle organization (GO:0071827)	3.62292216
80	benzene-containing compound metabolic process (GO:0042537)	3.61579039
81	serine family amino acid metabolic process (GO:0009069)	3.61513769
82	ketone body metabolic process (GO:1902224)	3.60996022
83	response to methylmercury (GO:0051597)	3.60596020
84	negative regulation of protein activation cascade (GO:2000258)	3.57952184
85	cofactor catabolic process (GO:0051187)	3.55468221
86	imidazole-containing compound metabolic process (GO:0052803)	3.55176125
87	amine catabolic process (GO:0009310)	3.51810662
88	cellular biogenic amine catabolic process (GO:0042402)	3.51810662
89	positive regulation of lipoprotein lipase activity (GO:0051006)	3.51200614
90	positive regulation of triglyceride lipase activity (GO:0061365)	3.51200614
91	arginine metabolic process (GO:0006525)	3.49484624
92	drug catabolic process (GO:0042737)	3.49307924
93	carboxylic acid catabolic process (GO:0046395)	3.44731180
94	organic acid catabolic process (GO:0016054)	3.44731180
95	short-chain fatty acid metabolic process (GO:0046459)	3.43972095
96	negative regulation of lipase activity (GO:0060192)	3.42135257
97	fibrinolysis (GO:0042730)	3.42099741
98	low-density lipoprotein particle remodeling (GO:0034374)	3.41468491
99	negative regulation of complement activation (GO:0045916)	3.41206845
100	positive regulation of lipid catabolic process (GO:0050996)	3.41085807
101	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.39096807
102	cellular glucuronidation (GO:0052695)	3.38382961
103	protein-lipid complex subunit organization (GO:0071825)	3.37387912
104	serine family amino acid biosynthetic process (GO:0009070)	3.36655836
105	positive regulation of extracellular matrix organization (GO:1903055)	3.36187400
106	low-density lipoprotein particle clearance (GO:0034383)	3.36047635
107	valine metabolic process (GO:0006573)	3.35535007
108	heme transport (GO:0015886)	3.34659851
109	blood coagulation, intrinsic pathway (GO:0007597)	3.33926792
110	regulation of apoptotic cell clearance (GO:2000425)	3.31757311
111	linoleic acid metabolic process (GO:0043651)	3.29188881
112	cholesterol homeostasis (GO:0042632)	3.28798931
113	aspartate family amino acid catabolic process (GO:0009068)	3.28118499
114	phospholipid homeostasis (GO:0055091)	3.27182512
115	dicarboxylic acid biosynthetic process (GO:0043650)	3.26371818
116	sterol homeostasis (GO:0055092)	3.23560531
117	drug transmembrane transport (GO:0006855)	3.22350379
118	2-oxoglutarate metabolic process (GO:0006103)	3.20865854
119	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	3.19659019
120	negative regulation of erythrocyte differentiation (GO:0045647)	3.15191693
121	positive regulation of receptor recycling (GO:0001921)	3.04506625
122	macroautophagy (GO:0016236)	3.01749031
123	positive regulation of hemostasis (GO:1900048)	2.96032299
124	positive regulation of blood coagulation (GO:0030194)	2.96032299
125	regulation of extracellular matrix disassembly (GO:0010715)	2.91887081
126	negative regulation of humoral immune response (GO:0002921)	2.90984436
127	creatine metabolic process (GO:0006600)	2.88744946
128	regulation of plasminogen activation (GO:0010755)	2.83190534
129	positive regulation of coagulation (GO:0050820)	2.83150932
130	ethanol metabolic process (GO:0006067)	2.83096618
131	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	2.79353684
132	regulation of cholesterol metabolic process (GO:0090181)	2.72179639
133	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.71398240
134	regulation of cholesterol biosynthetic process (GO:0045540)	2.70723829
135	basement membrane organization (GO:0071711)	2.70624531
136	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.69526315
137	hypotonic response (GO:0006971)	2.68263573
138	myeloid cell development (GO:0061515)	2.67203303
139	melanin biosynthetic process (GO:0042438)	2.63601323
140	response to mercury ion (GO:0046689)	2.61474153
141	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.60319780
142	detection of molecule of bacterial origin (GO:0032490)	2.60267246
143	negative regulation of protein localization to plasma membrane (GO:1903077)	2.59920434
144	regulation of extracellular matrix organization (GO:1903053)	2.58304192
145	negative regulation of fatty acid transport (GO:2000192)	2.58200241
146	modulation by virus of host process (GO:0019054)	2.52990951
147	tetrapyrrole metabolic process (GO:0033013)	2.49639641
148	modulation by symbiont of host cellular process (GO:0044068)	2.48905178
149	cellular response to epinephrine stimulus (GO:0071872)	2.41360194
150	cellular response to virus (GO:0098586)	2.38921968
151	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.38680532
152	positive regulation of fibroblast migration (GO:0010763)	2.36461412
153	erythrocyte differentiation (GO:0030218)	2.36401724
154	protein activation cascade (GO:0072376)	2.33841353
155	regulation of humoral immune response (GO:0002920)	2.30494544
156	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.29630062
157	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.29174378
158	mitochondrion degradation (GO:0000422)	2.27767757
159	regulation of integrin-mediated signaling pathway (GO:2001044)	2.27277172
160	cellular response to thyroid hormone stimulus (GO:0097067)	2.25965476
161	melanin metabolic process (GO:0006582)	2.25737414
162	regulation of fatty acid biosynthetic process (GO:0042304)	2.25132954
163	acute-phase response (GO:0006953)	2.24518159
164	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.22489435
165	regulation of receptor recycling (GO:0001919)	2.21844082

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.88136356
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.76034283
3	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.09730558
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	5.75907670
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.17092547
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.65486465
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.53568625
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.77158655
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.45985602
10	GATA1_22025678_ChIP-Seq_K562_Human	3.10411228
11	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.52422319
12	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.25976455
13	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.07961755
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.02614633
15	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.01054205
16	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.9811526
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.99381812
18	CLOCK_20551151_ChIP-Seq_293T_Human	1.98152297
19	TCF7_22412390_ChIP-Seq_EML_Mouse	1.74518774
20	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.74025000
21	KDM2B_26808549_Chip-Seq_K562_Human	1.71805412
22	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.69639568
23	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.65013599
24	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.56347641
25	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.56125404
26	GATA1_19941826_ChIP-Seq_K562_Human	1.54885099
27	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.50016057
28	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.48283533
29	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.45902850
30	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.39218922
31	KDM2B_26808549_Chip-Seq_DND41_Human	1.38195424
32	NCOR1_26117541_ChIP-Seq_K562_Human	1.37832745
33	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.32864103
34	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.32864103
35	SCL_19346495_ChIP-Seq_HPC-7_Human	1.32528484
36	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.31817167
37	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.31106327
38	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.30145413
39	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.30075739
40	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.29889288
41	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.26917089
42	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.26657365
43	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.26099213
44	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.25263460
45	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.24513005
46	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.24370876
47	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.22279518
48	VDR_21846776_ChIP-Seq_THP-1_Human	1.18353518
49	SPI1_23127762_ChIP-Seq_K562_Human	1.17919428
50	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16198632
51	ZNF263_19887448_ChIP-Seq_K562_Human	1.15898036
52	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.12606933
53	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.12480089
54	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.12354408
55	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.11549477
56	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.11406488
57	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.11149444
58	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.09896017
59	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.07358410
60	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.06882382
61	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06755001
62	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.06552969
63	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.06463839
64	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.05388410
65	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.05040069
66	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04801153
67	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.04779966
68	SMC4_20622854_ChIP-Seq_HELA_Human	1.04705491
69	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.04350287
70	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.03990040
71	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.03931199
72	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.03846061
73	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.02827607
74	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.02508977
75	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.02167648
76	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.01800391
77	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.00854233
78	GATA2_19941826_ChIP-Seq_K562_Human	0.99569307
79	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.97929826
80	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.96992696
81	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96167545
82	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.95842038
83	VDR_24763502_ChIP-Seq_THP-1_Human	0.94195426
84	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.92656305
85	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.92418727
86	LXR_22292898_ChIP-Seq_THP-1_Human	0.92180674
87	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.91863614
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91520608
89	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.90854214
90	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.90455935
91	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.89888707
92	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.89180022
93	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.85232093
94	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.83839564
95	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.82714715
96	GATA6_25053715_ChIP-Seq_YYC3_Human	0.77496202
97	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.74099774
98	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.72643092
99	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.70848945
100	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.68117869
101	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.67815305
102	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.66674085
103	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.65066569
104	CREB1_26743006_Chip-Seq_LNCaP_Human	0.64965935
105	ERG_20517297_ChIP-Seq_VCAP_Human	0.64903684
106	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.64630350
107	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.64399254
108	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.64381535
109	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.63194753
110	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.63022365
111	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.62881189
112	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.62268244
113	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.61635285
114	AR_20517297_ChIP-Seq_VCAP_Human	0.61208228
115	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.60704662
116	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.60680770
117	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.60566204
118	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.60532122
119	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.59415276
120	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.58028552
121	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.57997920
122	SOX2_20726797_ChIP-Seq_SW620_Human	0.56940985
123	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	0.55162784
124	RACK7_27058665_Chip-Seq_MCF-7_Human	0.55048740
125	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.54415010
126	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.53408346
127	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.53336088
128	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.53235870
129	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.53235870
130	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.50903914
131	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.50660920
132	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.50658348
133	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.50502886
134	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.50267159
135	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.49547564
136	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.49317893
137	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.48633129
138	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.48020496
139	BCAT_22108803_ChIP-Seq_LS180_Human	0.47300213
140	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.46822228
141	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.46798486
142	P53_21459846_ChIP-Seq_SAOS-2_Human	0.46682505
143	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.46171499
144	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.46072729
145	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.45909249
146	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.45244979
147	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.45045331
148	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.44934800

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.11734405
2	MP0005360_urolithiasis	6.37307313
3	MP0005365_abnormal_bile_salt	5.94019672
4	MP0005085_abnormal_gallbladder_physiolo	5.79087037
5	MP0008875_abnormal_xenobiotic_pharmacok	4.34974466
6	MP0005083_abnormal_biliary_tract	3.85125610
7	MP0003252_abnormal_bile_duct	3.63039846
8	MP0003806_abnormal_nucleotide_metabolis	3.34719960
9	MP0010329_abnormal_lipoprotein_level	3.31100724
10	MP0001666_abnormal_nutrient_absorption	3.21517580
11	MP0009840_abnormal_foam_cell	3.00117028
12	MP0003195_calcinosis	2.90597087
13	MP0008260_abnormal_autophagy	2.77980461
14	MP0003656_abnormal_erythrocyte_physiolo	2.75114360
15	MP0008438_abnormal_cutaneous_collagen	2.64184193
16	MP0005332_abnormal_amino_acid	2.52303938
17	MP0003172_abnormal_lysosome_physiology	2.50676463
18	MP0005171_absent_coat_pigmentation	2.44791217
19	MP0005058_abnormal_lysosome_morphology	2.36664691
20	MP0003868_abnormal_feces_composition	2.32981811
21	MP0004858_abnormal_nervous_system	2.13663562
22	MP0004381_abnormal_hair_follicle	2.13314413
23	MP0002132_abnormal_respiratory_system	2.13273097
24	MP0000609_abnormal_liver_physiology	2.10462674
25	MP0002138_abnormal_hepatobiliary_system	2.06797789
26	MP0002118_abnormal_lipid_homeostasis	2.06277734
27	MP0005409_darkened_coat_color	2.04420434
28	MP0005220_abnormal_exocrine_pancreas	1.97110934
29	MP0003191_abnormal_cellular_cholesterol	1.96587578
30	MP0003122_maternal_imprinting	1.88768888
31	MP0003566_abnormal_cell_adhesion	1.88743019
32	MP0004019_abnormal_vitamin_homeostasis	1.81533431
33	MP0005464_abnormal_platelet_physiology	1.75883110
34	MP0005319_abnormal_enzyme/_coenzyme	1.72936140
35	MP0000015_abnormal_ear_pigmentation	1.72528854
36	MP0000371_diluted_coat_color	1.62178014
37	MP0005257_abnormal_intraocular_pressure	1.58069440
38	MP0009643_abnormal_urine_homeostasis	1.57733294
39	MP0005075_abnormal_melanosome_morpholog	1.56238228
40	MP0005377_hearing/vestibular/ear_phenot	1.54624879
41	MP0003878_abnormal_ear_physiology	1.54624879
42	MP0000372_irregular_coat_pigmentation	1.51586146
43	MP0001958_emphysema	1.47873204
44	MP0005636_abnormal_mineral_homeostasis	1.46252974
45	MP0005275_abnormal_skin_tensile	1.44981096
46	MP0001764_abnormal_homeostasis	1.37318232
47	MP0004147_increased_porphyrin_level	1.36604352
48	MP0005584_abnormal_enzyme/coenzyme_acti	1.34756830
49	MP0003011_delayed_dark_adaptation	1.31198290
50	MP0001915_intracranial_hemorrhage	1.30522067
51	MP0004883_abnormal_blood_vessel	1.24714404
52	MP0003123_paternal_imprinting	1.24681500
53	MP0002078_abnormal_glucose_homeostasis	1.22317486
54	MP0001944_abnormal_pancreas_morphology	1.21202594
55	MP0006138_congestive_heart_failure	1.19753028
56	MP0003186_abnormal_redox_activity	1.18178513
57	MP0009780_abnormal_chondrocyte_physiolo	1.14691860
58	MP0004043_abnormal_pH_regulation	1.13820165
59	MP0005164_abnormal_response_to	1.10755473
60	MP0000598_abnormal_liver_morphology	1.10309613
61	MP0004272_abnormal_basement_membrane	1.07992667
62	MP0004264_abnormal_extraembryonic_tissu	1.06223775
63	MP0001545_abnormal_hematopoietic_system	1.05925438
64	MP0005397_hematopoietic_system_phenotyp	1.05925438
65	MP0002693_abnormal_pancreas_physiology	1.05186588
66	MP0003705_abnormal_hypodermis_morpholog	1.03290258
67	MP0003453_abnormal_keratinocyte_physiol	1.01430042
68	MP0003300_gastrointestinal_ulcer	1.01095596
69	MP0002089_abnormal_postnatal_growth/wei	0.98041991
70	MP0004233_abnormal_muscle_weight	0.97600396
71	MP0000749_muscle_degeneration	0.95553625
72	MP0010368_abnormal_lymphatic_system	0.94157010
73	MP0002108_abnormal_muscle_morphology	0.93651653
74	MP0003183_abnormal_peptide_metabolism	0.93161233
75	MP0005248_abnormal_Harderian_gland	0.93128692
76	MP0002254_reproductive_system_inflammat	0.92192792
77	MP0009053_abnormal_anal_canal	0.90988906
78	MP0001324_abnormal_eye_pigmentation	0.90460383
79	MP0005647_abnormal_sex_gland	0.90248526
80	MP0003436_decreased_susceptibility_to	0.89716812
81	MP0009642_abnormal_blood_homeostasis	0.87982452
82	MP0004145_abnormal_muscle_electrophysio	0.87428559
83	MP0003828_pulmonary_edema	0.86698921
84	MP0005503_abnormal_tendon_morphology	0.86629206
85	MP0002909_abnormal_adrenal_gland	0.86113933
86	MP0002075_abnormal_coat/hair_pigmentati	0.85961841
87	MP0000858_altered_metastatic_potential	0.85949714
88	MP0003279_aneurysm	0.85839415
89	MP0005535_abnormal_body_temperature	0.84533332
90	MP0001186_pigmentation_phenotype	0.84318389
91	MP0004185_abnormal_adipocyte_glucose	0.83269223
92	MP0001756_abnormal_urination	0.83235494
93	MP0009697_abnormal_copulation	0.82679615
94	MP0000604_amyloidosis	0.82421596
95	MP0003136_yellow_coat_color	0.81084435
96	MP0005076_abnormal_cell_differentiation	0.79617981
97	MP0003303_peritoneal_inflammation	0.79377139
98	MP0001851_eye_inflammation	0.78772525
99	MP0002837_dystrophic_cardiac_calcinosis	0.78641361
100	MP0005084_abnormal_gallbladder_morpholo	0.78628721
101	MP0000747_muscle_weakness	0.78221904
102	MP0005334_abnormal_fat_pad	0.78008181
103	MP0000751_myopathy	0.77839808
104	MP0005408_hypopigmentation	0.76894574
105	MP0005670_abnormal_white_adipose	0.76215347
106	MP0003879_abnormal_hair_cell	0.75745606
107	MP0009764_decreased_sensitivity_to	0.75402125
108	MP0009763_increased_sensitivity_to	0.75319553
109	MP0004036_abnormal_muscle_relaxation	0.74423656
110	MP0006036_abnormal_mitochondrial_physio	0.74343414
111	MP0000759_abnormal_skeletal_muscle	0.73667167
112	MP0003724_increased_susceptibility_to	0.73477757
113	MP0002095_abnormal_skin_pigmentation	0.73260650
114	MP0001849_ear_inflammation	0.72806805
115	MP0002877_abnormal_melanocyte_morpholog	0.72466420
116	MP0000639_abnormal_adrenal_gland	0.72404320
117	MP0002876_abnormal_thyroid_physiology	0.72048808
118	MP0010630_abnormal_cardiac_muscle	0.71424881
119	MP0005666_abnormal_adipose_tissue	0.70971549
120	MP0009931_abnormal_skin_appearance	0.70643875
121	MP0004087_abnormal_muscle_fiber	0.70223089
122	MP0003953_abnormal_hormone_level	0.69526283
123	MP0009765_abnormal_xenobiotic_induced	0.69518336
124	MP0000566_synostosis	0.69306839
125	MP0005448_abnormal_energy_balance	0.69290188
126	MP0002295_abnormal_pulmonary_circulatio	0.68450102
127	MP0003283_abnormal_digestive_organ	0.68002643
128	MP0005330_cardiomyopathy	0.66729101
129	MP0005174_abnormal_tail_pigmentation	0.66728273
130	MP0002060_abnormal_skin_morphology	0.66615826
131	MP0005451_abnormal_body_composition	0.66134001
132	MP0002928_abnormal_bile_duct	0.65172918
133	MP0000579_abnormal_nail_morphology	0.64474634
134	MP0005379_endocrine/exocrine_gland_phen	0.63609063
135	MP0008469_abnormal_protein_level	0.61993142
136	MP0005376_homeostasis/metabolism_phenot	0.60486484
137	MP0001881_abnormal_mammary_gland	0.59417786
138	MP0001661_extended_life_span	0.59058290
139	MP0001765_abnormal_ion_homeostasis	0.57617110
140	MP0002971_abnormal_brown_adipose	0.56996814
141	MP0003329_amyloid_beta_deposits	0.55200292
142	MP0005187_abnormal_penis_morphology	0.53454344
143	MP0004130_abnormal_muscle_cell	0.53192748
144	MP0000613_abnormal_salivary_gland	0.52371128
145	MP0002896_abnormal_bone_mineralization	0.52264673
146	MP0005646_abnormal_pituitary_gland	0.51825163
147	MP0003959_abnormal_lean_body	0.51018236
148	MP0000230_abnormal_systemic_arterial	0.49396108
149	MP0000462_abnormal_digestive_system	0.48113338
150	MP0003638_abnormal_response/metabolism_	0.47537224
151	MP0009384_cardiac_valve_regurgitation	0.47364058
152	MP0006054_spinal_hemorrhage	0.47173505
153	MP0008961_abnormal_basal_metabolism	0.46362259
154	MP0002098_abnormal_vibrissa_morphology	0.45100542
155	MP0009672_abnormal_birth_weight	0.44616668
156	MP0002970_abnormal_white_adipose	0.41758246
157	MP0002136_abnormal_kidney_physiology	0.41562491
158	MP0005266_abnormal_metabolism	0.39848316
159	MP0002135_abnormal_kidney_morphology	0.39290890
160	MP0008872_abnormal_physiological_respon	0.38458444
161	MP0001346_abnormal_lacrimal_gland	0.36718890
162	MP0002168_other_aberrant_phenotype	0.35915742
163	MP0005381_digestive/alimentary_phenotyp	0.35086890
164	MP0004782_abnormal_surfactant_physiolog	0.31894411
165	MP0005395_other_phenotype	0.30012770

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.05858369
2	Deep venous thrombosis (HP:0002625)	6.56391931
3	Intrahepatic cholestasis (HP:0001406)	6.31288063
4	Prolonged partial thromboplastin time (HP:0003645)	5.77285192
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.67758334
6	Xanthomatosis (HP:0000991)	5.63932252
7	Hypobetalipoproteinemia (HP:0003563)	5.29169515
8	Hypoglycemic coma (HP:0001325)	5.24464073
9	Hyperlipoproteinemia (HP:0010980)	4.63608431
10	Ketosis (HP:0001946)	4.46420716
11	Abnormality of the common coagulation pathway (HP:0010990)	4.41108320
12	Complement deficiency (HP:0004431)	4.39908045
13	Hypoglycemic seizures (HP:0002173)	4.16610979
14	Hypolipoproteinemia (HP:0010981)	4.16168312
15	Abnormality of the intrinsic pathway (HP:0010989)	4.12513550
16	Hypochromic anemia (HP:0001931)	4.07424130
17	Abnormal hemoglobin (HP:0011902)	4.04509672
18	Hyperbilirubinemia (HP:0002904)	4.03290677
19	Hyperglycinemia (HP:0002154)	3.90697724
20	Poikilocytosis (HP:0004447)	3.87339522
21	Hyperammonemia (HP:0001987)	3.85326845
22	Ketoacidosis (HP:0001993)	3.82224339
23	Hypoalphalipoproteinemia (HP:0003233)	3.81050919
24	Hypochromic microcytic anemia (HP:0004840)	3.79481355
25	Acanthocytosis (HP:0001927)	3.79082338
26	Fat malabsorption (HP:0002630)	3.76197099
27	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.69026328
28	Joint hemorrhage (HP:0005261)	3.68731865
29	Epidermoid cyst (HP:0200040)	3.67486504
30	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.67436798
31	Microcytic anemia (HP:0001935)	3.65255287
32	Hyperinsulinemic hypoglycemia (HP:0000825)	3.61341148
33	Protrusio acetabuli (HP:0003179)	3.54905567
34	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.54790890
35	Conjugated hyperbilirubinemia (HP:0002908)	3.53856155
36	Hyperglycinuria (HP:0003108)	3.42960370
37	Abnormality of glycine metabolism (HP:0010895)	3.38638915
38	Abnormality of serine family amino acid metabolism (HP:0010894)	3.38638915
39	Symptomatic seizures (HP:0011145)	3.34973089
40	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.28279571
41	Abnormality of methionine metabolism (HP:0010901)	3.27666136
42	Abnormal gallbladder morphology (HP:0012437)	3.23862076
43	Gingival bleeding (HP:0000225)	3.23566629
44	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.22396889
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.20509350
46	Abnormality of complement system (HP:0005339)	3.14592492
47	Cholelithiasis (HP:0001081)	3.13620317
48	Peritonitis (HP:0002586)	3.12555342
49	Abnormality of fatty-acid metabolism (HP:0004359)	3.05157816
50	Hepatocellular carcinoma (HP:0001402)	3.02544927
51	Late onset (HP:0003584)	2.98879204
52	Gout (HP:0001997)	2.91191157
53	Prolonged bleeding time (HP:0003010)	2.88369957
54	Hypercholesterolemia (HP:0003124)	2.86774324
55	Delayed CNS myelination (HP:0002188)	2.82334810
56	Generalized aminoaciduria (HP:0002909)	2.81689859
57	Arterial tortuosity (HP:0005116)	2.81411406
58	Abnormality of purine metabolism (HP:0004352)	2.79237431
59	Toxemia of pregnancy (HP:0100603)	2.78732808
60	Reticulocytosis (HP:0001923)	2.78203332
61	Steatorrhea (HP:0002570)	2.75579481
62	Abnormality of nucleobase metabolism (HP:0010932)	2.75499786
63	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.73743113
64	Metabolic acidosis (HP:0001942)	2.73704923
65	Vascular tortuosity (HP:0004948)	2.72546929
66	Gastrointestinal infarctions (HP:0005244)	2.68932047
67	Hyperglycemia (HP:0003074)	2.68564054
68	Abnormality of pyrimidine metabolism (HP:0004353)	2.68024496
69	Abnormality of endocrine pancreas physiology (HP:0012093)	2.63199245
70	Abnormality of the pancreatic islet cells (HP:0006476)	2.63199245
71	Abnormality of the gallbladder (HP:0005264)	2.58527611
72	Testicular neoplasm (HP:0010788)	2.51729146
73	Skin nodule (HP:0200036)	2.51336201
74	Flat acetabular roof (HP:0003180)	2.49000537
75	Irritability (HP:0000737)	2.47856848
76	Cholecystitis (HP:0001082)	2.45878065
77	Abnormal gallbladder physiology (HP:0012438)	2.45878065
78	Recurrent gram-negative bacterial infections (HP:0005420)	2.41700804
79	Hemorrhage of the eye (HP:0011885)	2.40383810
80	Vertebral compression fractures (HP:0002953)	2.39066803
81	Abnormality of serum amino acid levels (HP:0003112)	2.37185081
82	Dicarboxylic aciduria (HP:0003215)	2.36639281
83	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.36639281
84	Myocardial infarction (HP:0001658)	2.33046961
85	Purpura (HP:0000979)	2.33012861
86	Exercise-induced myalgia (HP:0003738)	2.30213148
87	Lethargy (HP:0001254)	2.26662813
88	Spontaneous abortion (HP:0005268)	2.26245454
89	Brushfield spots (HP:0001088)	2.25106019
90	Increased variability in muscle fiber diameter (HP:0003557)	2.17050032
91	Abnormality of carpal bone ossification (HP:0006257)	2.16265896
92	Pancreatitis (HP:0001733)	2.15941556
93	Epistaxis (HP:0000421)	2.15067274
94	Esophageal varix (HP:0002040)	2.13065520
95	Cerebral aneurysm (HP:0004944)	2.12331620
96	Menorrhagia (HP:0000132)	2.11595537
97	Mitral stenosis (HP:0001718)	2.11330100
98	Glomerulonephritis (HP:0000099)	2.10784497
99	Abnormality of reticulocytes (HP:0004312)	2.10708065
100	Vomiting (HP:0002013)	2.06759121
101	Increased connective tissue (HP:0009025)	2.06565274
102	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.06482301
103	Abnormality of polysaccharide metabolism (HP:0011012)	2.06482301
104	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.06482301
105	Type 1 muscle fiber predominance (HP:0003803)	2.06260610
106	Urinary glycosaminoglycan excretion (HP:0003541)	2.05872530
107	Mucopolysacchariduria (HP:0008155)	2.05872530
108	Cervical subluxation (HP:0003308)	2.05731021
109	Polycythemia (HP:0001901)	2.02714631
110	Rickets (HP:0002748)	2.02368814
111	Neonatal onset (HP:0003623)	2.00445302
112	Ovoid vertebral bodies (HP:0003300)	1.99548607
113	Eczematoid dermatitis (HP:0000976)	1.97998026
114	Cerebral edema (HP:0002181)	1.97994428
115	Ocular albinism (HP:0001107)	1.96946277
116	Enlarged kidneys (HP:0000105)	1.96393319
117	Asymmetric septal hypertrophy (HP:0001670)	1.96340774
118	Myopathic facies (HP:0002058)	1.94638283
119	Acute hepatic failure (HP:0006554)	1.93722383
120	Abnormality of proline metabolism (HP:0010907)	1.92939467
121	Hydroxyprolinuria (HP:0003080)	1.92939467
122	Abnormality of the acetabulum (HP:0003170)	1.92508124
123	Abnormality of iron homeostasis (HP:0011031)	1.92362128
124	Sensorimotor neuropathy (HP:0007141)	1.92115028
125	Ulnar deviation of the wrist (HP:0003049)	1.91918669
126	Spastic diplegia (HP:0001264)	1.91842323
127	Back pain (HP:0003418)	1.90309846
128	Opisthotonus (HP:0002179)	1.89471515
129	Ileus (HP:0002595)	1.88240928
130	Abnormal enzyme/coenzyme activity (HP:0012379)	1.86921178
131	Malnutrition (HP:0004395)	1.86694995
132	Turricephaly (HP:0000262)	1.86626387
133	Abnormality of skeletal muscle fiber size (HP:0012084)	1.86197396
134	Blue irides (HP:0000635)	1.86165355
135	Abnormality of transition element cation homeostasis (HP:0011030)	1.86003891
136	Bruising susceptibility (HP:0000978)	1.85941588
137	Cupped ribs (HP:0000887)	1.85905790
138	Broad palm (HP:0001169)	1.85808899
139	Aortic aneurysm (HP:0004942)	1.85632609
140	Metaphyseal cupping (HP:0003021)	1.85217747
141	Global brain atrophy (HP:0002283)	1.83941801
142	Systemic lupus erythematosus (HP:0002725)	1.83762958
143	Hypertriglyceridemia (HP:0002155)	1.83131187
144	Diaphragmatic weakness (HP:0009113)	1.82702956
145	Arthropathy (HP:0003040)	1.82549529
146	Protuberant abdomen (HP:0001538)	1.81974998
147	Coxa vara (HP:0002812)	1.81612974
148	Vascular calcification (HP:0004934)	1.81550001
149	Amyloidosis (HP:0011034)	1.80895283
150	Cerebral inclusion bodies (HP:0100314)	1.80671617
151	Germ cell neoplasia (HP:0100728)	1.80564875
152	Pancreatic islet-cell hyperplasia (HP:0004510)	1.79411962
153	Dysostosis multiplex (HP:0000943)	1.79135898
154	Difficulty running (HP:0009046)	1.76574549
155	Limb hypertonia (HP:0002509)	1.74974513
156	Osteomalacia (HP:0002749)	1.74559876
157	Increased serum ferritin (HP:0003281)	1.72592468
158	Orthostatic hypotension (HP:0001278)	1.71976524
159	Cardiovascular calcification (HP:0011915)	1.71685540
160	Abnormality of the peritoneum (HP:0002585)	1.71361647
161	Hyporeflexia of lower limbs (HP:0002600)	1.71117357
162	Atelectasis (HP:0100750)	1.71091424
163	Abnormal ossification of hand bones (HP:0005921)	1.71086134
164	Asymmetry of the thorax (HP:0001555)	1.70524258
165	Aneurysm (HP:0002617)	1.69592222
166	Flared iliac wings (HP:0002869)	1.68434229

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.90887294
2	ERN1	4.87836937
3	INSRR	4.81204894
4	SIK1	4.58005062
5	TAOK3	3.24505196
6	FGFR4	3.10858209
7	MAP2K3	2.96989529
8	TRIB3	2.91872781
9	MAPK15	2.46319103
10	ICK	2.36349024
11	NTRK1	2.24733515
12	PRPF4B	2.08974271
13	SIK3	2.06317523
14	FLT3	1.86729611
15	EEF2K	1.81499876
16	FRK	1.81495942
17	TAOK1	1.80679950
18	MAP3K2	1.66473264
19	TAOK2	1.62049725
20	IRAK2	1.61512620
21	EPHB2	1.59765512
22	MAPK11	1.53337978
23	PKN2	1.52888544
24	PTK6	1.52199103
25	WNK1	1.48128363
26	ERBB2	1.41908367
27	PASK	1.41673427
28	RIPK4	1.38854294
29	ERBB4	1.37470736
30	LATS1	1.34123140
31	TTN	1.33647193
32	PTK2B	1.32180404
33	KSR1	1.31820686
34	TRPM7	1.30640683
35	CDK12	1.27637997
36	MAP3K6	1.27627554
37	DYRK1B	1.21925299
38	MAP3K10	1.21391461
39	FGR	1.19376204
40	STK38	1.19156364
41	PDGFRA	1.17578181
42	MARK2	1.16453029
43	JAK2	1.16171660
44	PTK2	1.15857027
45	MET	1.15139904
46	TNK2	1.09541346
47	MAP2K2	1.07524472
48	IRAK1	1.07144087
49	OBSCN	1.05377675
50	PIK3CG	1.04444993
51	FGFR2	1.02641097
52	MAP2K4	1.01420079
53	MST1R	1.00879708
54	EPHA3	0.92446776
55	HIPK2	0.92173618
56	DMPK	0.91523240
57	RET	0.88655942
58	EIF2AK3	0.88508166
59	PDPK1	0.87287572
60	TYK2	0.85517410
61	ZAP70	0.84312683
62	TGFBR2	0.83685508
63	IRAK3	0.82867560
64	PIK3CA	0.81395428
65	SMG1	0.79833854
66	MARK3	0.78964944
67	RPS6KA2	0.78455298
68	CSK	0.78397093
69	PRKAA1	0.75750329
70	PRKCZ	0.75454256
71	MAP2K1	0.75315891
72	DAPK2	0.73234516
73	MAP3K1	0.73179313
74	GRK5	0.72104521
75	CAMK1D	0.70526581
76	MAP3K7	0.70014736
77	MAP3K3	0.69985170
78	MAPK12	0.69741092
79	STK4	0.68015696
80	PRKAA2	0.67985204
81	PRKACG	0.66701244
82	ABL2	0.66683509
83	SGK3	0.66569860
84	FER	0.65796006
85	BCR	0.65541525
86	YES1	0.65372666
87	GRK6	0.64873737
88	CHUK	0.64831061
89	NEK9	0.64132377
90	MAPKAPK3	0.64111341
91	WNK4	0.62300667
92	SGK1	0.62284596
93	MTOR	0.61792829
94	KDR	0.60948119
95	JAK1	0.60833204
96	TYRO3	0.58580768
97	DDR2	0.57965829
98	GSK3A	0.57806471
99	PAK3	0.56811714
100	EIF2AK1	0.56635520
101	BMX	0.54653284
102	PRKD3	0.54554759
103	PDK1	0.54351082
104	RPS6KL1	0.52664247
105	RPS6KC1	0.52664247
106	RAF1	0.52095316
107	SCYL2	0.51820520
108	DYRK3	0.50010099
109	CDK6	0.48845750
110	MAP3K5	0.47887631
111	SGK2	0.47083773
112	AKT3	0.46733973
113	SGK223	0.45850613
114	SGK494	0.45850613
115	HCK	0.45340659
116	RIPK1	0.42665306
117	PRKD1	0.42014710
118	PDGFRB	0.41476788
119	CAMK1G	0.41338137
120	MAPKAPK2	0.40130593
121	TBK1	0.40077847
122	IGF1R	0.39671453
123	LMTK2	0.39237352
124	RPS6KA6	0.37232036
125	PIM1	0.36881231
126	PRKCH	0.36020197
127	JAK3	0.35220554
128	MYLK	0.35029235
129	MATK	0.33787644
130	EGFR	0.33294997
131	CDC42BPA	0.30150344
132	MAP3K11	0.26840104
133	BRSK1	0.25979187
134	EPHB1	0.25880434
135	PRKCQ	0.25019787
136	CSNK1A1	0.24381217
137	FGFR3	0.24374589
138	PINK1	0.23169936
139	GRK1	0.22721994
140	KSR2	0.22287566
141	FGFR1	0.19189158
142	PRKD2	0.18992188
143	NUAK1	0.18747474
144	LRRK2	0.18466594
145	MAPK3	0.18246748
146	RPS6KB1	0.18197461
147	NTRK2	0.17689095

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.18507829
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.58188843
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.06268225
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.89714637
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.85437890
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.83719749
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.66996869
8	Fatty acid degradation_Homo sapiens_hsa00071	2.55865865
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.55195918
10	Complement and coagulation cascades_Homo sapiens_hsa04610	2.53006562
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.51857977
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.49880230
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.48541468
14	Butanoate metabolism_Homo sapiens_hsa00650	2.20417333
15	Sulfur metabolism_Homo sapiens_hsa00920	2.18429602
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.97970961
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.96810347
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.96637698
19	Propanoate metabolism_Homo sapiens_hsa00640	1.92178170
20	Peroxisome_Homo sapiens_hsa04146	1.91364555
21	Histidine metabolism_Homo sapiens_hsa00340	1.87934457
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.83617897
23	Other glycan degradation_Homo sapiens_hsa00511	1.83209089
24	Non-small cell lung cancer_Homo sapiens_hsa05223	1.74552504
25	PPAR signaling pathway_Homo sapiens_hsa03320	1.73330780
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.65533011
27	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.65471493
28	Malaria_Homo sapiens_hsa05144	1.64669467
29	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.62642385
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.62311538
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.61413695
32	Folate biosynthesis_Homo sapiens_hsa00790	1.57493832
33	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.50787517
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.50278182
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.50201224
36	Caffeine metabolism_Homo sapiens_hsa00232	1.49528434
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49519159
38	Fat digestion and absorption_Homo sapiens_hsa04975	1.48235878
39	Bile secretion_Homo sapiens_hsa04976	1.42413917
40	Tyrosine metabolism_Homo sapiens_hsa00350	1.41603682
41	Pancreatic cancer_Homo sapiens_hsa05212	1.39392987
42	Retinol metabolism_Homo sapiens_hsa00830	1.38642823
43	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.37796084
44	ABC transporters_Homo sapiens_hsa02010	1.37641850
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.34968826
46	Acute myeloid leukemia_Homo sapiens_hsa05221	1.33067162
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31484169
48	Pyruvate metabolism_Homo sapiens_hsa00620	1.31351126
49	Endometrial cancer_Homo sapiens_hsa05213	1.31287553
50	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.23889050
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.23767748
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.21953059
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.16080590
54	Fatty acid elongation_Homo sapiens_hsa00062	1.14092996
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08119092
56	Renal cell carcinoma_Homo sapiens_hsa05211	1.06296531
57	Steroid biosynthesis_Homo sapiens_hsa00100	1.01766358
58	Thyroid cancer_Homo sapiens_hsa05216	1.01572783
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.98458315
60	Sulfur relay system_Homo sapiens_hsa04122	0.97104783
61	FoxO signaling pathway_Homo sapiens_hsa04068	0.96592036
62	mTOR signaling pathway_Homo sapiens_hsa04150	0.96516710
63	Lysine degradation_Homo sapiens_hsa00310	0.96321377
64	Carbon metabolism_Homo sapiens_hsa01200	0.95496154
65	VEGF signaling pathway_Homo sapiens_hsa04370	0.95461675
66	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.95149855
67	Notch signaling pathway_Homo sapiens_hsa04330	0.91394924
68	ECM-receptor interaction_Homo sapiens_hsa04512	0.89723384
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89229377
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.81763260
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81363906
72	Amoebiasis_Homo sapiens_hsa05146	0.80924941
73	Choline metabolism in cancer_Homo sapiens_hsa05231	0.79365855
74	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.78523636
75	Focal adhesion_Homo sapiens_hsa04510	0.78284536
76	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.77233406
77	Protein export_Homo sapiens_hsa03060	0.77122196
78	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.76198247
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74631489
80	Small cell lung cancer_Homo sapiens_hsa05222	0.71899188
81	Prostate cancer_Homo sapiens_hsa05215	0.71264067
82	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.70196824
83	Glioma_Homo sapiens_hsa05214	0.69233300
84	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.69108508
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.67047685
86	Proteoglycans in cancer_Homo sapiens_hsa05205	0.66628351
87	Lysosome_Homo sapiens_hsa04142	0.66402584
88	Osteoclast differentiation_Homo sapiens_hsa04380	0.66204530
89	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.65937037
90	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.65827335
91	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.65634774
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65630618
93	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.64140496
94	Hepatitis C_Homo sapiens_hsa05160	0.64065908
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62346708
96	Platelet activation_Homo sapiens_hsa04611	0.59037844
97	ErbB signaling pathway_Homo sapiens_hsa04012	0.57149757
98	One carbon pool by folate_Homo sapiens_hsa00670	0.57046207
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56723914
100	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.56559929
101	Adherens junction_Homo sapiens_hsa04520	0.55785763
102	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.55202768
103	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54618868
104	Glutathione metabolism_Homo sapiens_hsa00480	0.54544237
105	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51516891
106	GnRH signaling pathway_Homo sapiens_hsa04912	0.51037301
107	Endocytosis_Homo sapiens_hsa04144	0.48681003
108	Circadian rhythm_Homo sapiens_hsa04710	0.47993265
109	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.47058174
110	Insulin resistance_Homo sapiens_hsa04931	0.46392461
111	Metabolic pathways_Homo sapiens_hsa01100	0.46206498
112	Galactose metabolism_Homo sapiens_hsa00052	0.45608908
113	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42876314
114	Prion diseases_Homo sapiens_hsa05020	0.40079967
115	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.35154707
116	Pentose phosphate pathway_Homo sapiens_hsa00030	0.31401603
117	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.31273379
118	Glucagon signaling pathway_Homo sapiens_hsa04922	0.30795161
119	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.26370219
120	AMPK signaling pathway_Homo sapiens_hsa04152	0.21573252
121	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.20366233
122	Linoleic acid metabolism_Homo sapiens_hsa00591	0.20201426
123	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.19562419
124	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.19075148
125	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.18396059
126	Bladder cancer_Homo sapiens_hsa05219	0.17616506
127	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.15872776
128	Insulin secretion_Homo sapiens_hsa04911	0.13968946
129	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.13281693
130	Insulin signaling pathway_Homo sapiens_hsa04910	0.12773044
131	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.12137819
132	Type II diabetes mellitus_Homo sapiens_hsa04930	0.10428067
133	Regulation of autophagy_Homo sapiens_hsa04140	0.09573790
134	Pancreatic secretion_Homo sapiens_hsa04972	0.07968822
135	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.02384873
136	Protein digestion and absorption_Homo sapiens_hsa04974	0.01845203
137	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.01046415
138	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.0308707
139	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.0296929
140	Cocaine addiction_Homo sapiens_hsa05030	-0.0113153
141	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	-0.0102611
142	Prolactin signaling pathway_Homo sapiens_hsa04917	-0.0025176
143	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.0023156

FAM210B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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