ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of synapse structural plasticity (GO:0051823)	7.72121037
2	pattern specification involved in kidney development (GO:0061004)	7.43749010
3	central nervous system myelination (GO:0022010)	6.28453437
4	axon ensheathment in central nervous system (GO:0032291)	6.28453437
5	negative regulation of activin receptor signaling pathway (GO:0032926)	5.63546158
6	negative regulation by host of viral transcription (GO:0043922)	5.62233225
7	prepulse inhibition (GO:0060134)	5.40844857
8	neuronal stem cell maintenance (GO:0097150)	5.19077016
9	adaptation of signaling pathway (GO:0023058)	5.09530855
10	regulation of T cell mediated cytotoxicity (GO:0001914)	4.91919411
11	positive regulation of T cell mediated cytotoxicity (GO:0001916)	4.87602240
12	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.63363003
13	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.63363003
14	regulation of memory T cell differentiation (GO:0043380)	4.56391415
15	tolerance induction (GO:0002507)	4.48514943
16	ubiquinone biosynthetic process (GO:0006744)	4.34642627
17	nephron tubule morphogenesis (GO:0072078)	4.34285737
18	nephron epithelium morphogenesis (GO:0072088)	4.34285737
19	auditory receptor cell differentiation (GO:0042491)	4.21649888
20	cilium or flagellum-dependent cell motility (GO:0001539)	4.21514002
21	ubiquinone metabolic process (GO:0006743)	4.19894440
22	neuron fate determination (GO:0048664)	4.14401358
23	regulation of cilium movement (GO:0003352)	4.14168075
24	cell proliferation in forebrain (GO:0021846)	4.09000566
25	astrocyte differentiation (GO:0048708)	4.07889362
26	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	4.04503702
27	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.94030817
28	radial glial cell differentiation (GO:0060019)	3.91993151
29	negative regulation of Rho protein signal transduction (GO:0035024)	3.87073077
30	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.75694159
31	alanine transport (GO:0032328)	3.74254634
32	positive regulation of defense response to virus by host (GO:0002230)	3.72980736
33	positive regulation of dendritic spine development (GO:0060999)	3.71343047
34	2-oxoglutarate metabolic process (GO:0006103)	3.68109137
35	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.65671054
36	segment specification (GO:0007379)	3.64337582
37	positive regulation of protein export from nucleus (GO:0046827)	3.61597319
38	L-fucose catabolic process (GO:0042355)	3.60653658
39	fucose catabolic process (GO:0019317)	3.60653658
40	L-fucose metabolic process (GO:0042354)	3.60653658
41	regulation of activated T cell proliferation (GO:0046006)	3.59590422
42	left/right pattern formation (GO:0060972)	3.54033235
43	positive regulation of cell fate commitment (GO:0010455)	3.52959070
44	quinone biosynthetic process (GO:1901663)	3.52003224
45	import into cell (GO:0098657)	3.51263339
46	mitotic cell cycle arrest (GO:0071850)	3.48909282
47	telencephalon development (GO:0021537)	3.46309715
48	positive regulation of immune response to tumor cell (GO:0002839)	3.43147395
49	regulation of immune response to tumor cell (GO:0002837)	3.43147395
50	regulation of response to tumor cell (GO:0002834)	3.43147395
51	positive regulation of response to tumor cell (GO:0002836)	3.43147395
52	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.39334305
53	positive regulation of Notch signaling pathway (GO:0045747)	3.30836117
54	nonmotile primary cilium assembly (GO:0035058)	3.25214747
55	protein import into peroxisome matrix (GO:0016558)	3.19390552
56	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.18174871
57	negative regulation of viral transcription (GO:0032897)	3.11037590
58	regulation of somitogenesis (GO:0014807)	3.09557787
59	negative regulation of cytokine secretion (GO:0050710)	3.06620382
60	hair cell differentiation (GO:0035315)	3.04365265
61	natural killer cell activation involved in immune response (GO:0002323)	3.03589459
62	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.96127411
63	isotype switching (GO:0045190)	2.96127411
64	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.96127411
65	cilium movement (GO:0003341)	2.91498032
66	smoothened signaling pathway (GO:0007224)	2.91331376
67	renal tubule morphogenesis (GO:0061333)	2.88519234
68	positive regulation of endothelial cell differentiation (GO:0045603)	2.84933973
69	positive regulation of T cell mediated immunity (GO:0002711)	2.84196875
70	phosphatidylcholine biosynthetic process (GO:0006656)	2.82809429
71	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.82777419
72	negative regulation of interleukin-17 production (GO:0032700)	2.81427496
73	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.80870254
74	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.76889754
75	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.75666800
76	positive regulation of T cell differentiation in thymus (GO:0033089)	2.75228148
77	regulation of mitochondrial fission (GO:0090140)	2.74540620
78	hindbrain development (GO:0030902)	2.72671793
79	regulation of G0 to G1 transition (GO:0070316)	2.71897752
80	regulation of endothelial cell differentiation (GO:0045601)	2.70839366
81	cellular response to exogenous dsRNA (GO:0071360)	2.70807619
82	positive regulation of dendrite development (GO:1900006)	2.70046668
83	modulation by host of symbiont transcription (GO:0052472)	2.69263208
84	modulation by host of viral transcription (GO:0043921)	2.69263208
85	regulation of microtubule-based movement (GO:0060632)	2.69235259
86	regulation of cell killing (GO:0031341)	2.69037141
87	regulation of synapse maturation (GO:0090128)	2.66401114
88	potassium ion import (GO:0010107)	2.65798889
89	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.65327874
90	response to caffeine (GO:0031000)	2.65010987
91	protein localization to microtubule cytoskeleton (GO:0072698)	2.64822279
92	regulation of chronic inflammatory response (GO:0002676)	2.64698892
93	negative regulation of mast cell activation (GO:0033004)	2.63678518
94	positive regulation of protein homodimerization activity (GO:0090073)	2.63505739
95	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.63244088
96	attachment of spindle microtubules to kinetochore (GO:0008608)	2.63088034
97	ovulation cycle (GO:0042698)	2.62699488
98	kynurenine metabolic process (GO:0070189)	2.62414897
99	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.61634112
100	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.61634112

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.39480250
2	IRF1_19129219_ChIP-ChIP_H3396_Human	3.19032001
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.17320738
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.06713350
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.99412433
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98136395
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.54076578
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.51395144
9	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.24773439
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19418469
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.17830895
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.07041477
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.05570402
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.03190981
15	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.02330079
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88591780
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.88428358
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87194310
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.83896629
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80636389
21	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.74321257
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.68421541
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.65870868
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.65211281
25	FUS_26573619_Chip-Seq_HEK293_Human	1.64440504
26	RUNX_20019798_ChIP-Seq_JUKART_Human	1.58630957
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58591603
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.57819144
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.56460812
30	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.52290730
31	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.50914167
32	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.48145440
33	AHR_22903824_ChIP-Seq_MCF-7_Human	1.48130856
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46608691
35	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.44193627
36	P300_19829295_ChIP-Seq_ESCs_Human	1.43235643
37	DROSHA_22980978_ChIP-Seq_HELA_Human	1.41525344
38	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.40625677
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40105802
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39167413
41	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.38349722
42	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37266277
43	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36839196
44	NCOR_22424771_ChIP-Seq_293T_Human	1.35749092
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.34417436
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33761678
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.33459270
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31768309
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30501242
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30132747
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29356164
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.29154909
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.29129401
54	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.28844775
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28492133
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28492133
57	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.26314745
58	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.25585664
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25436206
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25436206
61	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.25240124
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23953801
63	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23322190
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21681944
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.18955502
66	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.18898663
67	ERA_21632823_ChIP-Seq_H3396_Human	1.17998025
68	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.17560402
69	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17431735
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16700728
71	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15999496
72	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15716871
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15086689
74	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14710326
75	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11405948
76	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.10525535
77	AR_25329375_ChIP-Seq_VCAP_Human	1.08227778
78	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.05543451
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04974417
80	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.03730524
81	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02874116
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01356424
83	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01256167
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00164523
85	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.99463824
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98141338
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97514528
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97341881
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97126381
90	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.97010804
91	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.97010804
92	RXR_22108803_ChIP-Seq_LS180_Human	0.96622627
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96337332
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96273982
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95403352
96	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.94740884
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93569180
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93359997
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92211481
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91626921

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	8.12761428
2	MP0004885_abnormal_endolymph	6.36241012
3	MP0004147_increased_porphyrin_level	5.05788460
4	MP0003136_yellow_coat_color	4.63496111
5	MP0001485_abnormal_pinna_reflex	3.44123025
6	MP0004185_abnormal_adipocyte_glucose	3.41345989
7	MP0003011_delayed_dark_adaptation	2.76244824
8	MP0002277_abnormal_respiratory_mucosa	2.55824459
9	MP0003724_increased_susceptibility_to	2.46625580
10	MP0002638_abnormal_pupillary_reflex	2.44843251
11	MP0000569_abnormal_digit_pigmentation	2.42991089
12	MP0003183_abnormal_peptide_metabolism	2.13260654
13	MP0002938_white_spotting	2.07774806
14	MP0003283_abnormal_digestive_organ	2.00055422
15	MP0001873_stomach_inflammation	1.99057389
16	MP0002876_abnormal_thyroid_physiology	1.91401489
17	MP0008961_abnormal_basal_metabolism	1.78896480
18	MP0001529_abnormal_vocalization	1.71414740
19	MP0005171_absent_coat_pigmentation	1.55065355
20	MP0004133_heterotaxia	1.51753300
21	MP0002254_reproductive_system_inflammat	1.47403415
22	MP0005671_abnormal_response_to	1.46481001
23	MP0004142_abnormal_muscle_tone	1.45993975
24	MP0002139_abnormal_hepatobiliary_system	1.45753212
25	MP0005551_abnormal_eye_electrophysiolog	1.40695946
26	MP0004742_abnormal_vestibular_system	1.33106801
27	MP0002064_seizures	1.28875730
28	MP0000372_irregular_coat_pigmentation	1.21937947
29	MP0005503_abnormal_tendon_morphology	1.21658964
30	MP0003638_abnormal_response/metabolism_	1.20610643
31	MP0000427_abnormal_hair_cycle	1.20527275
32	MP0002249_abnormal_larynx_morphology	1.19767324
33	MP0005377_hearing/vestibular/ear_phenot	1.19140912
34	MP0003878_abnormal_ear_physiology	1.19140912
35	MP0001501_abnormal_sleep_pattern	1.18274203
36	MP0003195_calcinosis	1.17804273
37	MP0000371_diluted_coat_color	1.16658956
38	MP0005085_abnormal_gallbladder_physiolo	1.11177662
39	MP0010329_abnormal_lipoprotein_level	1.10297887
40	MP0001440_abnormal_grooming_behavior	1.10050639
41	MP0005360_urolithiasis	1.09546792
42	MP0006072_abnormal_retinal_apoptosis	1.04718089
43	MP0002736_abnormal_nociception_after	1.03781649
44	MP0008775_abnormal_heart_ventricle	1.03661689
45	MP0005084_abnormal_gallbladder_morpholo	1.02909516
46	MP0005666_abnormal_adipose_tissue	1.02368256
47	MP0001986_abnormal_taste_sensitivity	1.01046257
48	MP0001727_abnormal_embryo_implantation	0.98053395
49	MP0005253_abnormal_eye_physiology	0.97604856
50	MP0002572_abnormal_emotion/affect_behav	0.95232163
51	MP0009745_abnormal_behavioral_response	0.93474947
52	MP0004264_abnormal_extraembryonic_tissu	0.90473595
53	MP0005410_abnormal_fertilization	0.89914902
54	MP0000465_gastrointestinal_hemorrhage	0.89805660
55	MP0002733_abnormal_thermal_nociception	0.89117016
56	MP0001486_abnormal_startle_reflex	0.87775497
57	MP0004510_myositis	0.87685451
58	MP0009046_muscle_twitch	0.87629577
59	MP0003632_abnormal_nervous_system	0.86308103
60	MP0005167_abnormal_blood-brain_barrier	0.83281885
61	MP0010386_abnormal_urinary_bladder	0.81984567
62	MP0002067_abnormal_sensory_capabilities	0.81815401
63	MP0001970_abnormal_pain_threshold	0.81699328
64	MP0009840_abnormal_foam_cell	0.80576761
65	MP0000026_abnormal_inner_ear	0.77428767
66	MP0003635_abnormal_synaptic_transmissio	0.76984367
67	MP0008872_abnormal_physiological_respon	0.76802373
68	MP0005174_abnormal_tail_pigmentation	0.76309472
69	MP0002272_abnormal_nervous_system	0.72575996
70	MP0002877_abnormal_melanocyte_morpholog	0.71910097
71	MP0003656_abnormal_erythrocyte_physiolo	0.71769274
72	MP0001968_abnormal_touch/_nociception	0.71707093
73	MP0002557_abnormal_social/conspecific_i	0.70792400
74	MP0003646_muscle_fatigue	0.70563997
75	MP0001963_abnormal_hearing_physiology	0.69710297
76	MP0002095_abnormal_skin_pigmentation	0.68037774
77	MP0001188_hyperpigmentation	0.67045914
78	MP0001663_abnormal_digestive_system	0.66496133
79	MP0003303_peritoneal_inflammation	0.64742019
80	MP0002148_abnormal_hypersensitivity_rea	0.63699794
81	MP0005386_behavior/neurological_phenoty	0.62743478
82	MP0004924_abnormal_behavior	0.62743478
83	MP0002063_abnormal_learning/memory/cond	0.61946327
84	MP0002118_abnormal_lipid_homeostasis	0.61344879
85	MP0005670_abnormal_white_adipose	0.61253787
86	MP0005000_abnormal_immune_tolerance	0.61168974
87	MP0005448_abnormal_energy_balance	0.60416273
88	MP0000538_abnormal_urinary_bladder	0.59490708
89	MP0008877_abnormal_DNA_methylation	0.58960833
90	MP0003866_abnormal_defecation	0.58107346
91	MP0002751_abnormal_autonomic_nervous	0.57915209
92	MP0005332_abnormal_amino_acid	0.57688710
93	MP0001919_abnormal_reproductive_system	0.56612344
94	MP0000762_abnormal_tongue_morphology	0.50941413
95	MP0001502_abnormal_circadian_rhythm	0.50579355
96	MP0005195_abnormal_posterior_eye	0.50118909
97	MP0001533_abnormal_skeleton_physiology	0.48260202
98	MP0001664_abnormal_digestion	0.47738063
99	MP0005390_skeleton_phenotype	0.46289265
100	MP0002127_abnormal_cardiovascular_syste	0.46023898

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cochlea (HP:0000375)	6.96517968
2	Bilateral sensorineural hearing impairment (HP:0008619)	6.94547088
3	Morphological abnormality of the inner ear (HP:0011390)	5.50177033
4	Abnormality of dentin (HP:0010299)	5.42368758
5	Supernumerary bones of the axial skeleton (HP:0009144)	4.81021834
6	Conical tooth (HP:0000698)	4.49490798
7	Congenital stationary night blindness (HP:0007642)	4.40482816
8	Attenuation of retinal blood vessels (HP:0007843)	4.33442816
9	Spastic tetraparesis (HP:0001285)	4.04926128
10	Stomach cancer (HP:0012126)	3.76896673
11	Tinnitus (HP:0000360)	3.72773392
12	Lipid accumulation in hepatocytes (HP:0006561)	3.67722548
13	Abnormality of midbrain morphology (HP:0002418)	3.59560183
14	Molar tooth sign on MRI (HP:0002419)	3.59560183
15	Bronchomalacia (HP:0002780)	3.44837445
16	Vertebral hypoplasia (HP:0008417)	3.44215527
17	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	3.44215527
18	Midline defect of the nose (HP:0004122)	3.34729178
19	Abnormal number of erythroid precursors (HP:0012131)	3.18166823
20	Global brain atrophy (HP:0002283)	3.01853848
21	Vacuolated lymphocytes (HP:0001922)	2.91428052
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.84799929
23	Supernumerary ribs (HP:0005815)	2.80418239
24	Increased hepatocellular lipid droplets (HP:0006565)	2.75222647
25	Prostate neoplasm (HP:0100787)	2.73002433
26	Increased circulating renin level (HP:0000848)	2.69343278
27	Flat capital femoral epiphysis (HP:0003370)	2.66406971
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.63843828
29	Abnormality of the dental pulp (HP:0006479)	2.62887520
30	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.62772745
31	Mesangial abnormality (HP:0001966)	2.55521983
32	Neoplasm of the heart (HP:0100544)	2.53257198
33	Abnormality of the sella turcica (HP:0002679)	2.50200534
34	Bone cyst (HP:0012062)	2.42292224
35	True hermaphroditism (HP:0010459)	2.39200506
36	Arthropathy (HP:0003040)	2.38864287
37	IgG deficiency (HP:0004315)	2.35869494
38	Colon cancer (HP:0003003)	2.35641787
39	Nephronophthisis (HP:0000090)	2.35497545
40	Goiter (HP:0000853)	2.26506793
41	Renal cortical cysts (HP:0000803)	2.26374331
42	Hypoplastic ischia (HP:0003175)	2.26206803
43	Septo-optic dysplasia (HP:0100842)	2.25302741
44	Gait imbalance (HP:0002141)	2.22918885
45	Congenital primary aphakia (HP:0007707)	2.16336983
46	Medial flaring of the eyebrow (HP:0010747)	2.15368081
47	Focal motor seizures (HP:0011153)	2.13808297
48	Abnormality of the parietal bone (HP:0002696)	2.13503674
49	Pseudobulbar signs (HP:0002200)	2.12695116
50	Mesomelia (HP:0003027)	2.10052578
51	Trigonocephaly (HP:0000243)	2.08352186
52	Large for gestational age (HP:0001520)	2.07682975
53	Increased muscle lipid content (HP:0009058)	2.07298905
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06806309
55	Encephalitis (HP:0002383)	2.04132475
56	Spastic diplegia (HP:0001264)	2.03383961
57	Abnormality of the ischium (HP:0003174)	2.02049474
58	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.01928135
59	Beaking of vertebral bodies (HP:0004568)	2.00236977
60	Tracheomalacia (HP:0002779)	1.94581780
61	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.92885462
62	Short tibia (HP:0005736)	1.91427855
63	Abnormal rod and cone electroretinograms (HP:0008323)	1.91381307
64	Humeroradial synostosis (HP:0003041)	1.91131054
65	Synostosis involving the elbow (HP:0003938)	1.91131054
66	Abnormal spermatogenesis (HP:0008669)	1.90739156
67	Progressive microcephaly (HP:0000253)	1.90101549
68	Failure to thrive in infancy (HP:0001531)	1.86139889
69	Renal Fanconi syndrome (HP:0001994)	1.85733286
70	Congenital, generalized hypertrichosis (HP:0004540)	1.85025156
71	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.84878396
72	Neoplasm of the thyroid gland (HP:0100031)	1.82714102
73	Hemiparesis (HP:0001269)	1.82051525
74	Birth length less than 3rd percentile (HP:0003561)	1.81642103
75	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.81124536
76	Short 4th metacarpal (HP:0010044)	1.81124536
77	Thick nail (HP:0001805)	1.80505016
78	Abnormal glucose tolerance (HP:0001952)	1.80282409
79	Retrobulbar optic neuritis (HP:0100654)	1.79733329
80	Optic neuritis (HP:0100653)	1.79733329
81	Fibular hypoplasia (HP:0003038)	1.77990331
82	Increased number of teeth (HP:0011069)	1.73935322
83	Broad-based gait (HP:0002136)	1.72314311
84	Abnormality of the diencephalon (HP:0010662)	1.71915494
85	Neoplasm of the oral cavity (HP:0100649)	1.70437121
86	Nephrogenic diabetes insipidus (HP:0009806)	1.70173571
87	Bilateral microphthalmos (HP:0007633)	1.69862674
88	Polydipsia (HP:0001959)	1.69544617
89	Abnormal drinking behavior (HP:0030082)	1.69544617
90	Broad face (HP:0000283)	1.67559017
91	Intellectual disability, progressive (HP:0006887)	1.67531436
92	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.66922135
93	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.66576631
94	Tracheal stenosis (HP:0002777)	1.65787928
95	Non-midline cleft lip (HP:0100335)	1.64325289
96	Hypomagnesemia (HP:0002917)	1.64220533
97	Brittle hair (HP:0002299)	1.62748804
98	Exertional dyspnea (HP:0002875)	1.61897233
99	Benign neoplasm of the central nervous system (HP:0100835)	1.60140926
100	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.59685129

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMK1D	8.19135995
2	CAMKK2	7.69202945
3	CAMK1G	5.57331282
4	TAOK3	4.80724165
5	BMPR1B	3.40361049
6	CAMKK1	3.21015452
7	PNCK	2.22615830
8	TLK1	1.93130671
9	CAMK4	1.72958266
10	WNK4	1.58916894
11	NEK1	1.55541780
12	CAMK1	1.53683715
13	WNK3	1.44681069
14	MAPK15	1.40876045
15	GRK1	1.40016881
16	MAP2K2	1.39327635
17	ACVR1B	1.35959986
18	MET	1.34778475
19	EPHB1	1.19195089
20	WEE1	1.16697594
21	RIPK4	1.13685621
22	NLK	1.01542075
23	TGFBR1	0.92700861
24	STK39	0.90991884
25	MAP4K2	0.89439663
26	OXSR1	0.83131244
27	BUB1	0.74635110
28	KIT	0.73846984
29	PKN1	0.70295843
30	PRKD2	0.69043036
31	TAOK1	0.67059399
32	EPHA3	0.66668157
33	TSSK6	0.66432538
34	CSNK1G1	0.66109989
35	EPHA4	0.64695668
36	TYRO3	0.64571103
37	NEK2	0.64010278
38	SIK2	0.61832231
39	ERBB2	0.61291275
40	IKBKB	0.60979387
41	EPHB2	0.60527983
42	WNK1	0.59974817
43	DAPK2	0.59782421
44	MAP4K1	0.57692447
45	SGK2	0.56132864
46	JAK1	0.54366047
47	SGK223	0.51865779
48	SGK494	0.51865779
49	PHKG2	0.51536765
50	PHKG1	0.51536765
51	ZAK	0.51530225
52	PRKCG	0.48102438
53	SYK	0.45435476
54	CHUK	0.43123185
55	LIMK1	0.42560430
56	MATK	0.41453489
57	CDK3	0.39458694
58	PTK2B	0.39103078
59	GRK6	0.38004644
60	PRKCH	0.37354445
61	FGR	0.36805442
62	MAP2K1	0.36721881
63	PRKCE	0.36232675
64	MAP3K11	0.35190401
65	PRKCQ	0.33791010
66	ADRBK2	0.33516426
67	ERBB3	0.32017231
68	MAP3K4	0.28280815
69	NTRK2	0.26486820
70	MAPKAPK2	0.25034653
71	VRK1	0.23731047
72	PIM1	0.22471079
73	LCK	0.21901540
74	PRKCI	0.20157368
75	MAP2K4	0.19174281
76	IGF1R	0.18986592
77	INSR	0.18938764
78	MARK3	0.18563018
79	DYRK2	0.17491598
80	CSNK1G3	0.16647125
81	GSK3A	0.16609529
82	LYN	0.14922046
83	CSNK1G2	0.14051437
84	MARK2	0.13855985
85	PRKCD	0.13076726
86	MAPK12	0.12855277
87	PRKD1	0.12481722
88	STK38	0.12351402
89	ABL1	0.11460708
90	STK4	0.11418909
91	CSNK1A1	0.11289623
92	INSRR	0.11228968
93	PIK3CA	0.11197575
94	JAK3	0.10511498
95	IRAK4	0.09767141
96	PDGFRB	0.09508326
97	MAP2K6	0.09259136
98	MKNK2	0.08950489
99	YES1	0.08585691
100	PRKCZ	0.08410332

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.73659042
2	Butanoate metabolism_Homo sapiens_hsa00650	3.26785019
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.98475796
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.61584223
5	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.60263711
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34231530
7	Phototransduction_Homo sapiens_hsa04744	2.23512015
8	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.05550720
9	RNA polymerase_Homo sapiens_hsa03020	2.04169896
10	PPAR signaling pathway_Homo sapiens_hsa03320	2.01385472
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98007089
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.73183085
13	Taste transduction_Homo sapiens_hsa04742	1.69442460
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.67672777
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.66326161
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.65320178
17	Basal transcription factors_Homo sapiens_hsa03022	1.49541819
18	Huntingtons disease_Homo sapiens_hsa05016	1.47847605
19	Nicotine addiction_Homo sapiens_hsa05033	1.46402440
20	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.40396030
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38744520
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.36278494
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34402042
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.32976795
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.32785957
26	Notch signaling pathway_Homo sapiens_hsa04330	1.30968581
27	Protein export_Homo sapiens_hsa03060	1.29314282
28	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.28735683
29	Cocaine addiction_Homo sapiens_hsa05030	1.28695507
30	African trypanosomiasis_Homo sapiens_hsa05143	1.27098408
31	Peroxisome_Homo sapiens_hsa04146	1.24427655
32	Parkinsons disease_Homo sapiens_hsa05012	1.22349524
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.22324573
34	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.20066983
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.19832262
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17383054
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.16494309
38	GABAergic synapse_Homo sapiens_hsa04727	1.16310734
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14877138
40	Morphine addiction_Homo sapiens_hsa05032	1.12690621
41	Arginine biosynthesis_Homo sapiens_hsa00220	1.11800849
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.11664073
43	Gastric acid secretion_Homo sapiens_hsa04971	1.08598550
44	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.08285676
45	Amphetamine addiction_Homo sapiens_hsa05031	1.07627967
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04373848
47	Sulfur relay system_Homo sapiens_hsa04122	1.04251789
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03885959
49	Allograft rejection_Homo sapiens_hsa05330	1.02694545
50	Caffeine metabolism_Homo sapiens_hsa00232	1.02477393
51	Malaria_Homo sapiens_hsa05144	1.01375284
52	Insulin secretion_Homo sapiens_hsa04911	1.01092969
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99298630
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.97913239
55	Primary immunodeficiency_Homo sapiens_hsa05340	0.97664741
56	Glutathione metabolism_Homo sapiens_hsa00480	0.92588355
57	Legionellosis_Homo sapiens_hsa05134	0.89194807
58	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.88680549
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.86497269
60	Circadian entrainment_Homo sapiens_hsa04713	0.86199639
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86080996
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86025265
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.85669215
64	Alzheimers disease_Homo sapiens_hsa05010	0.85192618
65	Renin-angiotensin system_Homo sapiens_hsa04614	0.83890835
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82719129
67	ABC transporters_Homo sapiens_hsa02010	0.78521257
68	Bile secretion_Homo sapiens_hsa04976	0.77473686
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73410638
70	Salivary secretion_Homo sapiens_hsa04970	0.70577694
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68706415
72	Axon guidance_Homo sapiens_hsa04360	0.64877892
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.63488766
74	Serotonergic synapse_Homo sapiens_hsa04726	0.62995087
75	Histidine metabolism_Homo sapiens_hsa00340	0.62392644
76	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.60691008
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59346713
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58175875
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.58169591
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.58115627
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.57619311
82	Retinol metabolism_Homo sapiens_hsa00830	0.56328067
83	Cholinergic synapse_Homo sapiens_hsa04725	0.55088111
84	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53611458
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47334693
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.46101668
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45871392
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44286463
89	Estrogen signaling pathway_Homo sapiens_hsa04915	0.42887525
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.42487184
91	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38953869
92	Long-term depression_Homo sapiens_hsa04730	0.36565110
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.34476551
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.32414760
95	Asthma_Homo sapiens_hsa05310	0.31540302
96	Other glycan degradation_Homo sapiens_hsa00511	0.31375625
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29287357
98	Olfactory transduction_Homo sapiens_hsa04740	0.29104107
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28603182
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.27826967

FAM210CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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