

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 7.70981011 |
| 2 | endothelium development (GO:0003158) | 6.11642627 |
| 3 | DNA deamination (GO:0045006) | 6.05199904 |
| 4 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 5.93983687 |
| 5 | viral transcription (GO:0019083) | 5.91944020 |
| 6 | translational termination (GO:0006415) | 5.67157804 |
| 7 | thrombin receptor signaling pathway (GO:0070493) | 5.55406852 |
| 8 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.43421541 |
| 9 | definitive hemopoiesis (GO:0060216) | 5.31611669 |
| 10 | maturation of SSU-rRNA (GO:0030490) | 5.17260214 |
| 11 | platelet dense granule organization (GO:0060155) | 5.05535178 |
| 12 | translational elongation (GO:0006414) | 4.99228618 |
| 13 | pyrimidine nucleotide catabolic process (GO:0006244) | 4.95232173 |
| 14 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.94119371 |
| 15 | cotranslational protein targeting to membrane (GO:0006613) | 4.80712801 |
| 16 | protein targeting to ER (GO:0045047) | 4.79391161 |
| 17 | response to interferon-beta (GO:0035456) | 4.78112147 |
| 18 | ribosomal small subunit biogenesis (GO:0042274) | 4.77930862 |
| 19 | deoxyribonucleotide catabolic process (GO:0009264) | 4.60593195 |
| 20 | protein localization to endoplasmic reticulum (GO:0070972) | 4.57759201 |
| 21 | aggressive behavior (GO:0002118) | 4.56681190 |
| 22 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.55835903 |
| 23 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 4.52194689 |
| 24 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 4.47875227 |
| 25 | antigen processing and presentation via MHC class Ib (GO:0002475) | 4.43372945 |
| 26 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.40261597 |
| 27 | viral life cycle (GO:0019058) | 4.39501407 |
| 28 | deoxyribose phosphate catabolic process (GO:0046386) | 4.37760532 |
| 29 | cellular protein complex disassembly (GO:0043624) | 4.19634540 |
| 30 | translational initiation (GO:0006413) | 4.19424697 |
| 31 | negative regulation of erythrocyte differentiation (GO:0045647) | 4.09535352 |
| 32 | megakaryocyte development (GO:0035855) | 4.01807119 |
| 33 | response to interferon-alpha (GO:0035455) | 4.01233678 |
| 34 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.89189151 |
| 35 | angiogenesis involved in wound healing (GO:0060055) | 3.87098086 |
| 36 | seminiferous tubule development (GO:0072520) | 3.85063446 |
| 37 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.82588463 |
| 38 | negative regulation of B cell apoptotic process (GO:0002903) | 3.79558611 |
| 39 | B cell mediated immunity (GO:0019724) | 3.77587963 |
| 40 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.76739059 |
| 41 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.76515149 |
| 42 | protein complex disassembly (GO:0043241) | 3.74236645 |
| 43 | DNA strand elongation (GO:0022616) | 3.73798187 |
| 44 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 3.73577668 |
| 45 | endosome to pigment granule transport (GO:0043485) | 3.69061649 |
| 46 | endosome to melanosome transport (GO:0035646) | 3.69061649 |
| 47 | mature B cell differentiation involved in immune response (GO:0002313) | 3.66578898 |
| 48 | actin nucleation (GO:0045010) | 3.60691859 |
| 49 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.58031717 |
| 50 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.54439266 |
| 51 | ribosomal large subunit biogenesis (GO:0042273) | 3.53350181 |
| 52 | neutrophil activation involved in immune response (GO:0002283) | 3.52469100 |
| 53 | purine nucleotide salvage (GO:0032261) | 3.51253689 |
| 54 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.49808658 |
| 55 | macromolecular complex disassembly (GO:0032984) | 3.48814595 |
| 56 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 3.41908093 |
| 57 | telomere maintenance via recombination (GO:0000722) | 3.41070380 |
| 58 | positive regulation of B cell differentiation (GO:0045579) | 3.40421264 |
| 59 | proteasome assembly (GO:0043248) | 3.38880733 |
| 60 | mRNA catabolic process (GO:0006402) | 3.38271305 |
| 61 | positive regulation of granulocyte differentiation (GO:0030854) | 3.35350487 |
| 62 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.35328380 |
| 63 | pseudouridine synthesis (GO:0001522) | 3.32418292 |
| 64 | regulation of B cell apoptotic process (GO:0002902) | 3.32135567 |
| 65 | deoxyribose phosphate metabolic process (GO:0019692) | 3.30923544 |
| 66 | nucleotide salvage (GO:0043173) | 3.27145382 |
| 67 | lymphoid progenitor cell differentiation (GO:0002320) | 3.26760604 |
| 68 | DNA replication initiation (GO:0006270) | 3.26138802 |
| 69 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.24650319 |
| 70 | regulation of B cell differentiation (GO:0045577) | 3.22577749 |
| 71 | RNA catabolic process (GO:0006401) | 3.21649712 |
| 72 | negative regulation of viral entry into host cell (GO:0046597) | 3.21163892 |
| 73 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.20070826 |
| 74 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.20070826 |
| 75 | regulation of antigen processing and presentation (GO:0002577) | 3.18084623 |
| 76 | UV protection (GO:0009650) | 3.17151722 |
| 77 | positive regulation of antigen processing and presentation (GO:0002579) | 3.16033107 |
| 78 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 3.16001145 |
| 79 | protein targeting to membrane (GO:0006612) | 3.14663420 |
| 80 | lipoxygenase pathway (GO:0019372) | 3.14351622 |
| 81 | base-excision repair, AP site formation (GO:0006285) | 3.14265305 |
| 82 | lymph node development (GO:0048535) | 3.11210527 |
| 83 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.09293417 |
| 84 | cellular response to exogenous dsRNA (GO:0071360) | 3.07950245 |
| 85 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.06808175 |
| 86 | purine-containing compound salvage (GO:0043101) | 3.04270079 |
| 87 | erythrocyte maturation (GO:0043249) | 3.03232122 |
| 88 | translation (GO:0006412) | 3.02518106 |
| 89 | secretory granule organization (GO:0033363) | 3.01845821 |
| 90 | autophagic vacuole fusion (GO:0000046) | 3.00382491 |
| 91 | mitotic recombination (GO:0006312) | 3.00177601 |
| 92 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.99591533 |
| 93 | regulation of platelet aggregation (GO:0090330) | 2.99104074 |
| 94 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.97969702 |
| 95 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.96430874 |
| 96 | deoxyribonucleotide metabolic process (GO:0009262) | 2.95085832 |
| 97 | DNA unwinding involved in DNA replication (GO:0006268) | 2.94578223 |
| 98 | cellular response to interferon-beta (GO:0035458) | 2.94396403 |
| 99 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.94193189 |
| 100 | rRNA processing (GO:0006364) | 2.92850471 |
| 101 | negative regulation of interleukin-17 production (GO:0032700) | 2.91494238 |
| 102 | positive regulation of vasculogenesis (GO:2001214) | 2.91332192 |
| 103 | purinergic receptor signaling pathway (GO:0035587) | 2.91199725 |
| 104 | platelet aggregation (GO:0070527) | 2.91021745 |
| 105 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.90996624 |
| 106 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.90996624 |
| 107 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.90669633 |
| 108 | regulation of erythrocyte differentiation (GO:0045646) | 2.89484710 |
| 109 | embryonic hemopoiesis (GO:0035162) | 2.87404328 |
| 110 | formation of translation preinitiation complex (GO:0001731) | 2.85377757 |
| 111 | T cell homeostasis (GO:0043029) | 2.85195354 |
| 112 | protein neddylation (GO:0045116) | 2.84836562 |
| 113 | pinocytosis (GO:0006907) | 2.84739666 |
| 114 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.83862118 |
| 115 | rRNA metabolic process (GO:0016072) | 2.83174999 |
| 116 | viral mRNA export from host cell nucleus (GO:0046784) | 2.82305033 |
| 117 | telomere maintenance via telomere lengthening (GO:0010833) | 2.81099983 |
| 118 | mature B cell differentiation (GO:0002335) | 2.80261484 |
| 119 | blood vessel maturation (GO:0001955) | 2.79627086 |
| 120 | B cell receptor signaling pathway (GO:0050853) | 2.79031179 |
| 121 | mast cell activation (GO:0045576) | 2.78056834 |
| 122 | histamine secretion (GO:0001821) | 2.77477371 |
| 123 | negative regulation of phagocytosis (GO:0050765) | 2.75641258 |
| 124 | regulation of megakaryocyte differentiation (GO:0045652) | 2.75501746 |
| 125 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.74893195 |
| 126 | termination of RNA polymerase III transcription (GO:0006386) | 2.74893195 |
| 127 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 2.73458394 |
| 128 | ribosome biogenesis (GO:0042254) | 2.73254652 |
| 129 | granulocyte differentiation (GO:0030851) | 2.73074595 |
| 130 | protein maturation by protein folding (GO:0022417) | 2.72515099 |
| 131 | response to peptidoglycan (GO:0032494) | 2.70555795 |
| 132 | negative regulation of viral genome replication (GO:0045071) | 2.70437974 |
| 133 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 2.69361516 |
| 134 | defense response to protozoan (GO:0042832) | 2.68692016 |
| 135 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.67849270 |
| 136 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.66336929 |
| 137 | cardiolipin metabolic process (GO:0032048) | 2.65825934 |
| 138 | immunoglobulin mediated immune response (GO:0016064) | 2.63220574 |
| 139 | nucleobase biosynthetic process (GO:0046112) | 2.62990236 |
| 140 | cellular component biogenesis (GO:0044085) | 2.62822740 |
| 141 | tRNA methylation (GO:0030488) | 2.62750824 |
| 142 | response to protozoan (GO:0001562) | 2.61810971 |
| 143 | regulation of hypersensitivity (GO:0002883) | 2.61635474 |
| 144 | positive thymic T cell selection (GO:0045059) | 2.61211036 |
| 145 | cell wall macromolecule catabolic process (GO:0016998) | 2.60382960 |
| 146 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.59841719 |
| 147 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.59841719 |
| 148 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.59561850 |
| 149 | type I interferon signaling pathway (GO:0060337) | 2.59371049 |
| 150 | cellular response to type I interferon (GO:0071357) | 2.59371049 |
| 151 | regulation of female receptivity (GO:0045924) | 2.59276467 |
| 152 | response to type I interferon (GO:0034340) | 2.58797984 |
| 153 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.58695235 |
| 154 | female mating behavior (GO:0060180) | 2.58677504 |
| 155 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.58399022 |
| 156 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.58134942 |
| 157 | isotype switching (GO:0045190) | 2.58134942 |
| 158 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.58134942 |
| 159 | blood coagulation, intrinsic pathway (GO:0007597) | 2.58059473 |
| 160 | ubiquinone biosynthetic process (GO:0006744) | 2.57686931 |
| 161 | CENP-A containing nucleosome assembly (GO:0034080) | 2.57019358 |
| 162 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.56931858 |
| 163 | regulation of platelet activation (GO:0010543) | 2.56411946 |
| 164 | B cell activation involved in immune response (GO:0002312) | 2.55984224 |
| 165 | protein complex biogenesis (GO:0070271) | 2.55155218 |
| 166 | IMP biosynthetic process (GO:0006188) | 2.55022492 |
| 167 | purine nucleobase biosynthetic process (GO:0009113) | 2.54314693 |
| 168 | regulation of mast cell degranulation (GO:0043304) | 2.54238040 |
| 169 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.52300234 |
| 170 | myeloid dendritic cell activation (GO:0001773) | 2.51937967 |
| 171 | mast cell degranulation (GO:0043303) | 2.51552065 |
| 172 | mast cell activation involved in immune response (GO:0002279) | 2.51552065 |
| 173 | negative regulation of T cell apoptotic process (GO:0070233) | 2.51260266 |
| 174 | grooming behavior (GO:0007625) | 2.50752806 |
| 175 | IMP metabolic process (GO:0046040) | 2.50359579 |
| 176 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.49597939 |
| 177 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.49584103 |
| 178 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.49427121 |
| 179 | cyclooxygenase pathway (GO:0019371) | 2.48601983 |
| 180 | Peyers patch development (GO:0048541) | 2.46098396 |
| 181 | phosphatidylglycerol biosynthetic process (GO:0006655) | 2.43642315 |
| 182 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.43403141 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.58091083 |
| 2 | SCL_19346495_ChIP-Seq_HPC-7_Human | 3.82532835 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.72998605 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.41602431 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.05204051 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.90686107 |
| 7 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.89504252 |
| 8 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.74372592 |
| 9 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.63533655 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.58416513 |
| 11 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.56230532 |
| 12 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.46342029 |
| 13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.39853306 |
| 14 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.39000884 |
| 15 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.38831153 |
| 16 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.38772520 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.37017213 |
| 18 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.36009444 |
| 19 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.33246154 |
| 20 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.32861426 |
| 21 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.28345774 |
| 22 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.27661407 |
| 23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.27538776 |
| 24 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.22472867 |
| 25 | MYC_22102868_ChIP-Seq_BL_Human | 2.20904093 |
| 26 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.17335559 |
| 27 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.12417746 |
| 28 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.11326620 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.10785389 |
| 30 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.09647243 |
| 31 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 2.07882897 |
| 32 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 2.06499533 |
| 33 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.05754895 |
| 34 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.03190284 |
| 35 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.01336495 |
| 36 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.98339520 |
| 37 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.92274939 |
| 38 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.90924209 |
| 39 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.90384051 |
| 40 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.90243298 |
| 41 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.84133339 |
| 42 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.83924213 |
| 43 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.82389306 |
| 44 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.76065279 |
| 45 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.74545103 |
| 46 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.70063538 |
| 47 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.70018981 |
| 48 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.69595189 |
| 49 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.69019722 |
| 50 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.68916382 |
| 51 | GATA1_22025678_ChIP-Seq_K562_Human | 1.65257729 |
| 52 | GATA1_19941826_ChIP-Seq_K562_Human | 1.65224483 |
| 53 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.64588059 |
| 54 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64148415 |
| 55 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.64054030 |
| 56 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.62590556 |
| 57 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.62412091 |
| 58 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.62346050 |
| 59 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.59489855 |
| 60 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.58686965 |
| 61 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.58350442 |
| 62 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.55829619 |
| 63 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.55472299 |
| 64 | SPI1_23127762_ChIP-Seq_K562_Human | 1.54233992 |
| 65 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.53094372 |
| 66 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.52339038 |
| 67 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.50941865 |
| 68 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.44953961 |
| 69 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.44694855 |
| 70 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.44492013 |
| 71 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.43649294 |
| 72 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.43515703 |
| 73 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.43320441 |
| 74 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.38553993 |
| 75 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.38350927 |
| 76 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.37903825 |
| 77 | MAF_26560356_Chip-Seq_TH1_Human | 1.37450368 |
| 78 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.37331328 |
| 79 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.36527159 |
| 80 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.36222112 |
| 81 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.34555431 |
| 82 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.34455508 |
| 83 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.32603701 |
| 84 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.32473697 |
| 85 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.31855780 |
| 86 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.29948438 |
| 87 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.29679752 |
| 88 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.29026679 |
| 89 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.27648121 |
| 90 | MYB_26560356_Chip-Seq_TH2_Human | 1.27602598 |
| 91 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.25530813 |
| 92 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.25349438 |
| 93 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.25143239 |
| 94 | MYB_26560356_Chip-Seq_TH1_Human | 1.24653165 |
| 95 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.23111435 |
| 96 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.19075034 |
| 97 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.17931397 |
| 98 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.17605028 |
| 99 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.16420023 |
| 100 | UTX_26944678_Chip-Seq_JUKART_Human | 1.16401446 |
| 101 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.15520186 |
| 102 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.15069571 |
| 103 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.15029000 |
| 104 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.13556856 |
| 105 | GATA2_19941826_ChIP-Seq_K562_Human | 1.11955115 |
| 106 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.11134012 |
| 107 | P300_27268052_Chip-Seq_Bcells_Human | 1.10479672 |
| 108 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.10441155 |
| 109 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.09735733 |
| 110 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.09511547 |
| 111 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.09185481 |
| 112 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.08458523 |
| 113 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.08423583 |
| 114 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.07857726 |
| 115 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.06867642 |
| 116 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.06360948 |
| 117 | P68_20966046_ChIP-Seq_HELA_Human | 1.04852782 |
| 118 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.04006472 |
| 119 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.03780153 |
| 120 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.03661733 |
| 121 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.01985651 |
| 122 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.00647932 |
| 123 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.00088974 |
| 124 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.00012462 |
| 125 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.00010746 |
| 126 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.99857462 |
| 127 | MAF_26560356_Chip-Seq_TH2_Human | 0.99720666 |
| 128 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.99597535 |
| 129 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.99317084 |
| 130 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.99235793 |
| 131 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99184503 |
| 132 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.99022737 |
| 133 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.98896499 |
| 134 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.98781982 |
| 135 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.98508821 |
| 136 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.92605603 |
| 137 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.92311258 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002396_abnormal_hematopoietic_system | 4.42265500 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.20538249 |
| 3 | MP0004147_increased_porphyrin_level | 3.18937044 |
| 4 | MP0004808_abnormal_hematopoietic_stem | 3.17735000 |
| 5 | MP0001835_abnormal_antigen_presentation | 2.82779558 |
| 6 | MP0005397_hematopoietic_system_phenotyp | 2.82007427 |
| 7 | MP0001545_abnormal_hematopoietic_system | 2.82007427 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.68224313 |
| 9 | MP0000685_abnormal_immune_system | 2.57545610 |
| 10 | MP0005464_abnormal_platelet_physiology | 2.53013332 |
| 11 | MP0005671_abnormal_response_to | 2.47759122 |
| 12 | MP0000465_gastrointestinal_hemorrhage | 2.41646925 |
| 13 | MP0006054_spinal_hemorrhage | 2.37679312 |
| 14 | MP0000490_abnormal_crypts_of | 2.31829991 |
| 15 | MP0008007_abnormal_cellular_replicative | 2.30743469 |
| 16 | MP0005174_abnormal_tail_pigmentation | 2.28485351 |
| 17 | MP0010094_abnormal_chromosome_stability | 2.25338963 |
| 18 | MP0009785_altered_susceptibility_to | 2.24365005 |
| 19 | MP0005075_abnormal_melanosome_morpholog | 2.15932187 |
| 20 | MP0002398_abnormal_bone_marrow | 2.13982610 |
| 21 | MP0009379_abnormal_foot_pigmentation | 1.99415761 |
| 22 | MP0005451_abnormal_body_composition | 1.95063590 |
| 23 | MP0003077_abnormal_cell_cycle | 1.94202847 |
| 24 | MP0002166_altered_tumor_susceptibility | 1.91889731 |
| 25 | MP0003763_abnormal_thymus_physiology | 1.91162884 |
| 26 | MP0000689_abnormal_spleen_morphology | 1.88938206 |
| 27 | MP0010368_abnormal_lymphatic_system | 1.88343596 |
| 28 | MP0003724_increased_susceptibility_to | 1.87209647 |
| 29 | MP0008058_abnormal_DNA_repair | 1.84825783 |
| 30 | MP0005025_abnormal_response_to | 1.83599080 |
| 31 | MP0002722_abnormal_immune_system | 1.83238868 |
| 32 | MP0003303_peritoneal_inflammation | 1.82009036 |
| 33 | MP0001800_abnormal_humoral_immune | 1.80959660 |
| 34 | MP0002095_abnormal_skin_pigmentation | 1.79291087 |
| 35 | MP0008057_abnormal_DNA_replication | 1.79128523 |
| 36 | MP0002452_abnormal_antigen_presenting | 1.77526024 |
| 37 | MP0009333_abnormal_splenocyte_physiolog | 1.76444984 |
| 38 | MP0002420_abnormal_adaptive_immunity | 1.76356472 |
| 39 | MP0003111_abnormal_nucleus_morphology | 1.76218312 |
| 40 | MP0004957_abnormal_blastocyst_morpholog | 1.74610546 |
| 41 | MP0002148_abnormal_hypersensitivity_rea | 1.74609436 |
| 42 | MP0001819_abnormal_immune_cell | 1.73859700 |
| 43 | MP0002429_abnormal_blood_cell | 1.69519034 |
| 44 | MP0002723_abnormal_immune_serum | 1.67874302 |
| 45 | MP0000716_abnormal_immune_system | 1.66483451 |
| 46 | MP0009278_abnormal_bone_marrow | 1.64932722 |
| 47 | MP0008004_abnormal_stomach_pH | 1.60377693 |
| 48 | MP0010155_abnormal_intestine_physiology | 1.59813986 |
| 49 | MP0003866_abnormal_defecation | 1.59060241 |
| 50 | MP0003436_decreased_susceptibility_to | 1.58504920 |
| 51 | MP0002132_abnormal_respiratory_system | 1.58094560 |
| 52 | MP0002419_abnormal_innate_immunity | 1.56080128 |
| 53 | MP0003656_abnormal_erythrocyte_physiolo | 1.56060166 |
| 54 | MP0001873_stomach_inflammation | 1.51512205 |
| 55 | MP0005646_abnormal_pituitary_gland | 1.50638780 |
| 56 | MP0005167_abnormal_blood-brain_barrier | 1.48576354 |
| 57 | MP0005000_abnormal_immune_tolerance | 1.47678918 |
| 58 | MP0003943_abnormal_hepatobiliary_system | 1.45449945 |
| 59 | MP0005165_increased_susceptibility_to | 1.41835920 |
| 60 | MP0001879_abnormal_lymphatic_vessel | 1.41737974 |
| 61 | MP0000703_abnormal_thymus_morphology | 1.39532097 |
| 62 | MP0002006_tumorigenesis | 1.38394732 |
| 63 | MP0001853_heart_inflammation | 1.33532254 |
| 64 | MP0003718_maternal_effect | 1.33038956 |
| 65 | MP0005058_abnormal_lysosome_morphology | 1.27331804 |
| 66 | MP0002019_abnormal_tumor_incidence | 1.25447590 |
| 67 | MP0001790_abnormal_immune_system | 1.21037593 |
| 68 | MP0005387_immune_system_phenotype | 1.21037593 |
| 69 | MP0009764_decreased_sensitivity_to | 1.18114048 |
| 70 | MP0002405_respiratory_system_inflammati | 1.17474325 |
| 71 | MP0002877_abnormal_melanocyte_morpholog | 1.16970338 |
| 72 | MP0000372_irregular_coat_pigmentation | 1.14237779 |
| 73 | MP0000230_abnormal_systemic_arterial | 1.13007661 |
| 74 | MP0005645_abnormal_hypothalamus_physiol | 1.12350396 |
| 75 | MP0003567_abnormal_fetal_cardiomyocyte | 1.11942418 |
| 76 | MP0005410_abnormal_fertilization | 1.10090989 |
| 77 | MP0000313_abnormal_cell_death | 1.09548758 |
| 78 | MP0001845_abnormal_inflammatory_respons | 1.02979771 |
| 79 | MP0009697_abnormal_copulation | 1.02808776 |
| 80 | MP0003786_premature_aging | 1.01517198 |
| 81 | MP0000015_abnormal_ear_pigmentation | 1.01189363 |
| 82 | MP0003075_altered_response_to | 0.99831582 |
| 83 | MP0008469_abnormal_protein_level | 0.98097911 |
| 84 | MP0000343_altered_response_to | 0.97063333 |
| 85 | MP0000013_abnormal_adipose_tissue | 0.96152275 |
| 86 | MP0003828_pulmonary_edema | 0.95716819 |
| 87 | MP0008872_abnormal_physiological_respon | 0.92861897 |
| 88 | MP0001905_abnormal_dopamine_level | 0.92123677 |
| 89 | MP0003279_aneurysm | 0.90351289 |
| 90 | MP0006292_abnormal_olfactory_placode | 0.88750805 |
| 91 | MP0004084_abnormal_cardiac_muscle | 0.87975021 |
| 92 | MP0006036_abnormal_mitochondrial_physio | 0.87043886 |
| 93 | MP0002075_abnormal_coat/hair_pigmentati | 0.84189788 |
| 94 | MP0003638_abnormal_response/metabolism_ | 0.84080308 |
| 95 | MP0000858_altered_metastatic_potential | 0.82055471 |
| 96 | MP0002138_abnormal_hepatobiliary_system | 0.81524169 |
| 97 | MP0005409_darkened_coat_color | 0.81324506 |
| 98 | MP0008775_abnormal_heart_ventricle | 0.81015027 |
| 99 | MP0006035_abnormal_mitochondrial_morpho | 0.79981059 |
| 100 | MP0003191_abnormal_cellular_cholesterol | 0.79807989 |
| 101 | MP0009765_abnormal_xenobiotic_induced | 0.78243595 |
| 102 | MP0001533_abnormal_skeleton_physiology | 0.77996213 |
| 103 | MP0008932_abnormal_embryonic_tissue | 0.76627098 |
| 104 | MP0000350_abnormal_cell_proliferation | 0.75548293 |
| 105 | MP0002938_white_spotting | 0.74737549 |
| 106 | MP0003186_abnormal_redox_activity | 0.74467491 |
| 107 | MP0000249_abnormal_blood_vessel | 0.74178972 |
| 108 | MP0002009_preneoplasia | 0.72380276 |
| 109 | MP0000477_abnormal_intestine_morphology | 0.71271125 |
| 110 | MP0004036_abnormal_muscle_relaxation | 0.71000498 |
| 111 | MP0001663_abnormal_digestive_system | 0.70871653 |
| 112 | MP0005390_skeleton_phenotype | 0.70644284 |
| 113 | MP0001188_hyperpigmentation | 0.70578904 |
| 114 | MP0010307_abnormal_tumor_latency | 0.70462310 |
| 115 | MP0000516_abnormal_urinary_system | 0.70324577 |
| 116 | MP0005367_renal/urinary_system_phenotyp | 0.70324577 |
| 117 | MP0005595_abnormal_vascular_smooth | 0.67501928 |
| 118 | MP0003315_abnormal_perineum_morphology | 0.67214664 |
| 119 | MP0003172_abnormal_lysosome_physiology | 0.67203010 |
| 120 | MP0004510_myositis | 0.66660754 |
| 121 | MP0008873_increased_physiological_sensi | 0.66600579 |
| 122 | MP0002089_abnormal_postnatal_growth/wei | 0.66555212 |
| 123 | MP0000598_abnormal_liver_morphology | 0.66400640 |
| 124 | MP0004947_skin_inflammation | 0.65612127 |
| 125 | MP0000767_abnormal_smooth_muscle | 0.64373551 |
| 126 | MP0000358_abnormal_cell_content/ | 0.64337220 |
| 127 | MP0005535_abnormal_body_temperature | 0.63162791 |
| 128 | MP0002080_prenatal_lethality | 0.61989375 |
| 129 | MP0005084_abnormal_gallbladder_morpholo | 0.61893375 |
| 130 | MP0009763_increased_sensitivity_to | 0.58531795 |
| 131 | MP0001986_abnormal_taste_sensitivity | 0.56712827 |
| 132 | MP0009931_abnormal_skin_appearance | 0.56522647 |
| 133 | MP0002128_abnormal_blood_circulation | 0.55523268 |
| 134 | MP0002933_joint_inflammation | 0.54907395 |
| 135 | MP0000681_abnormal_thyroid_gland | 0.53753872 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.63699230 |
| 2 | Aplastic anemia (HP:0001915) | 5.63116341 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 5.60111965 |
| 4 | Thrombocytosis (HP:0001894) | 5.39436228 |
| 5 | Petechiae (HP:0000967) | 4.77968950 |
| 6 | Reticulocytopenia (HP:0001896) | 4.63590578 |
| 7 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 4.58761342 |
| 8 | Increased mean platelet volume (HP:0011877) | 4.58375538 |
| 9 | Prolonged bleeding time (HP:0003010) | 4.58373445 |
| 10 | Menorrhagia (HP:0000132) | 4.25649119 |
| 11 | IgM deficiency (HP:0002850) | 4.04533818 |
| 12 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.63247305 |
| 13 | Pallor (HP:0000980) | 3.59967459 |
| 14 | Abnormal platelet function (HP:0011869) | 3.33159727 |
| 15 | Impaired platelet aggregation (HP:0003540) | 3.33159727 |
| 16 | Abnormal pupillary function (HP:0007686) | 3.30139493 |
| 17 | Epistaxis (HP:0000421) | 3.29395105 |
| 18 | Macrocytic anemia (HP:0001972) | 3.21202251 |
| 19 | Chronic otitis media (HP:0000389) | 3.19358938 |
| 20 | Type 2 muscle fiber atrophy (HP:0003554) | 3.14289490 |
| 21 | Reduced antithrombin III activity (HP:0001976) | 3.09142557 |
| 22 | Muscle fiber atrophy (HP:0100295) | 3.05689035 |
| 23 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.05496709 |
| 24 | Colon cancer (HP:0003003) | 3.04375543 |
| 25 | Stomatitis (HP:0010280) | 3.01605907 |
| 26 | Autoimmune hemolytic anemia (HP:0001890) | 3.00065627 |
| 27 | Increased intramyocellular lipid droplets (HP:0012240) | 2.98450525 |
| 28 | Panhypogammaglobulinemia (HP:0003139) | 2.94057043 |
| 29 | Purpura (HP:0000979) | 2.94013808 |
| 30 | 3-Methylglutaconic aciduria (HP:0003535) | 2.92891620 |
| 31 | Hepatosplenomegaly (HP:0001433) | 2.88263163 |
| 32 | Increased muscle lipid content (HP:0009058) | 2.88053583 |
| 33 | Abnormality of T cell physiology (HP:0011840) | 2.84160408 |
| 34 | Myositis (HP:0100614) | 2.83497985 |
| 35 | Type I transferrin isoform profile (HP:0003642) | 2.82151665 |
| 36 | Encephalitis (HP:0002383) | 2.81587979 |
| 37 | Abnormality of lateral ventricle (HP:0030047) | 2.80127410 |
| 38 | Myelodysplasia (HP:0002863) | 2.79656625 |
| 39 | Cellulitis (HP:0100658) | 2.79041481 |
| 40 | Amaurosis fugax (HP:0100576) | 2.77544578 |
| 41 | Microvesicular hepatic steatosis (HP:0001414) | 2.76024948 |
| 42 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.70912008 |
| 43 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.70912008 |
| 44 | Recurrent abscess formation (HP:0002722) | 2.64425938 |
| 45 | Chronic obstructive pulmonary disease (HP:0006510) | 2.62303147 |
| 46 | Obstructive lung disease (HP:0006536) | 2.62303147 |
| 47 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.60331742 |
| 48 | Recurrent cutaneous fungal infections (HP:0011370) | 2.60331742 |
| 49 | Poikiloderma (HP:0001029) | 2.58772596 |
| 50 | Acute myeloid leukemia (HP:0004808) | 2.55490614 |
| 51 | B lymphocytopenia (HP:0010976) | 2.55025712 |
| 52 | Abnormality of B cell number (HP:0010975) | 2.55025712 |
| 53 | Entropion (HP:0000621) | 2.52964051 |
| 54 | Decreased central vision (HP:0007663) | 2.49143041 |
| 55 | Dry hair (HP:0011359) | 2.46749980 |
| 56 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.46048767 |
| 57 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.46048767 |
| 58 | Abnormal protein glycosylation (HP:0012346) | 2.46048767 |
| 59 | Abnormal glycosylation (HP:0012345) | 2.46048767 |
| 60 | Recurrent viral infections (HP:0004429) | 2.44401461 |
| 61 | Recurrent bacterial skin infections (HP:0005406) | 2.43904487 |
| 62 | Granulocytopenia (HP:0001913) | 2.43061386 |
| 63 | Dicarboxylic aciduria (HP:0003215) | 2.42729720 |
| 64 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.42729720 |
| 65 | Pancytopenia (HP:0001876) | 2.42643291 |
| 66 | Microcytic anemia (HP:0001935) | 2.42265704 |
| 67 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.41946227 |
| 68 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.41806311 |
| 69 | Hepatocellular necrosis (HP:0001404) | 2.39003770 |
| 70 | Hepatic necrosis (HP:0002605) | 2.38301015 |
| 71 | Spontaneous hematomas (HP:0007420) | 2.37472632 |
| 72 | Lymphoma (HP:0002665) | 2.36781318 |
| 73 | Hypoproteinemia (HP:0003075) | 2.34567220 |
| 74 | Hypertensive crisis (HP:0100735) | 2.32114296 |
| 75 | Birth length less than 3rd percentile (HP:0003561) | 2.28969276 |
| 76 | Hyperthyroidism (HP:0000836) | 2.25811642 |
| 77 | Abnormality of iron homeostasis (HP:0011031) | 2.23469183 |
| 78 | Agammaglobulinemia (HP:0004432) | 2.22367583 |
| 79 | Visual hallucinations (HP:0002367) | 2.20818492 |
| 80 | Nonprogressive disorder (HP:0003680) | 2.20617124 |
| 81 | Ragged-red muscle fibers (HP:0003200) | 2.20420043 |
| 82 | Cerebral palsy (HP:0100021) | 2.20243270 |
| 83 | Abnormality of the prostate (HP:0008775) | 2.18433104 |
| 84 | Increased serum ferritin (HP:0003281) | 2.17191082 |
| 85 | Increased IgE level (HP:0003212) | 2.16202658 |
| 86 | Recurrent bronchitis (HP:0002837) | 2.15515237 |
| 87 | IgG deficiency (HP:0004315) | 2.13507225 |
| 88 | Acute lymphatic leukemia (HP:0006721) | 2.13361034 |
| 89 | 11 pairs of ribs (HP:0000878) | 2.12247201 |
| 90 | Mediastinal lymphadenopathy (HP:0100721) | 2.12066094 |
| 91 | Mitochondrial inheritance (HP:0001427) | 2.11553090 |
| 92 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.10587753 |
| 93 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.09052595 |
| 94 | Congenital, generalized hypertrichosis (HP:0004540) | 2.07873161 |
| 95 | Albinism (HP:0001022) | 2.06344189 |
| 96 | Meningitis (HP:0001287) | 2.06230700 |
| 97 | Gastrointestinal inflammation (HP:0004386) | 2.04905530 |
| 98 | Oral leukoplakia (HP:0002745) | 2.01279873 |
| 99 | Viral hepatitis (HP:0006562) | 2.00518274 |
| 100 | Radial bowing (HP:0002986) | 1.99737306 |
| 101 | Abnormality of the columella (HP:0009929) | 1.97685734 |
| 102 | Increased IgM level (HP:0003496) | 1.97104176 |
| 103 | Hypergammaglobulinemia (HP:0010702) | 1.96990640 |
| 104 | Dyschromatopsia (HP:0007641) | 1.96457458 |
| 105 | Agnosia (HP:0010524) | 1.96122690 |
| 106 | Paralysis (HP:0003470) | 1.95915901 |
| 107 | Poor head control (HP:0002421) | 1.95701442 |
| 108 | Abnormality of T cells (HP:0002843) | 1.95278451 |
| 109 | Weak cry (HP:0001612) | 1.95248679 |
| 110 | Selective tooth agenesis (HP:0001592) | 1.95035885 |
| 111 | Abnormality of the nasal mucosa (HP:0000433) | 1.94548407 |
| 112 | Abnormality of reticulocytes (HP:0004312) | 1.93556436 |
| 113 | Inflammation of the large intestine (HP:0002037) | 1.91717658 |
| 114 | Erythema (HP:0010783) | 1.90889088 |
| 115 | Acute hepatic failure (HP:0006554) | 1.90061253 |
| 116 | Severe combined immunodeficiency (HP:0004430) | 1.89736892 |
| 117 | Exertional dyspnea (HP:0002875) | 1.88651716 |
| 118 | Spontaneous abortion (HP:0005268) | 1.88041963 |
| 119 | Gingival bleeding (HP:0000225) | 1.87096121 |
| 120 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.86413303 |
| 121 | Thoracic kyphosis (HP:0002942) | 1.84974469 |
| 122 | Bone marrow hypocellularity (HP:0005528) | 1.83995732 |
| 123 | Recurrent fungal infections (HP:0002841) | 1.83812122 |
| 124 | Patchy hypopigmentation of hair (HP:0011365) | 1.82947180 |
| 125 | Basal cell carcinoma (HP:0002671) | 1.82311342 |
| 126 | Episodic fever (HP:0001954) | 1.81572149 |
| 127 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.81453297 |
| 128 | Asplenia (HP:0001746) | 1.81083041 |
| 129 | Beaking of vertebral bodies (HP:0004568) | 1.80987684 |
| 130 | Lymphopenia (HP:0001888) | 1.80703943 |
| 131 | Increased CSF lactate (HP:0002490) | 1.80163797 |
| 132 | Skin rash (HP:0000988) | 1.79304478 |
| 133 | Areflexia of lower limbs (HP:0002522) | 1.79171782 |
| 134 | Neutropenia (HP:0001875) | 1.78855527 |
| 135 | Rhabdomyolysis (HP:0003201) | 1.77711861 |
| 136 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.74521752 |
| 137 | Migraine (HP:0002076) | 1.73770191 |
| 138 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.73621412 |
| 139 | Bruising susceptibility (HP:0000978) | 1.73505202 |
| 140 | Pustule (HP:0200039) | 1.73206877 |
| 141 | Premature graying of hair (HP:0002216) | 1.73077909 |
| 142 | Pulmonary fibrosis (HP:0002206) | 1.71671077 |
| 143 | Respiratory difficulties (HP:0002880) | 1.71652439 |
| 144 | Abnormal platelet volume (HP:0011876) | 1.71606181 |
| 145 | Microretrognathia (HP:0000308) | 1.70780866 |
| 146 | Colitis (HP:0002583) | 1.68689039 |
| 147 | Recurrent skin infections (HP:0001581) | 1.68241602 |
| 148 | Vacuolated lymphocytes (HP:0001922) | 1.66994816 |
| 149 | Chest pain (HP:0100749) | 1.64014855 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 3.36848808 |
| 2 | KIT | 3.03494031 |
| 3 | VRK2 | 2.86253106 |
| 4 | WEE1 | 2.83491425 |
| 5 | STK16 | 2.80583107 |
| 6 | MAP2K3 | 2.51773443 |
| 7 | MUSK | 2.47886101 |
| 8 | MAP4K1 | 2.46075135 |
| 9 | FLT3 | 2.44857957 |
| 10 | TESK2 | 2.36345921 |
| 11 | TIE1 | 2.33612977 |
| 12 | TGFBR1 | 2.32204218 |
| 13 | KDR | 2.30076609 |
| 14 | TGFBR2 | 2.22680405 |
| 15 | BTK | 2.16748740 |
| 16 | BMPR1B | 2.11302112 |
| 17 | TEC | 1.84228470 |
| 18 | BUB1 | 1.83991429 |
| 19 | EEF2K | 1.82136450 |
| 20 | NUAK1 | 1.77972173 |
| 21 | MKNK1 | 1.77493423 |
| 22 | VRK1 | 1.76278344 |
| 23 | PIM2 | 1.72579838 |
| 24 | CDK8 | 1.71162567 |
| 25 | EIF2AK1 | 1.68008170 |
| 26 | INSRR | 1.59983091 |
| 27 | ZAP70 | 1.58062335 |
| 28 | ACVR1B | 1.54833345 |
| 29 | TNIK | 1.51659001 |
| 30 | BRSK2 | 1.50430935 |
| 31 | MAP4K2 | 1.49998980 |
| 32 | GRK6 | 1.47357196 |
| 33 | RPS6KB2 | 1.46114778 |
| 34 | MAPKAPK5 | 1.46032798 |
| 35 | JAK3 | 1.42169000 |
| 36 | TBK1 | 1.41346627 |
| 37 | GRK1 | 1.40340628 |
| 38 | DYRK3 | 1.39947900 |
| 39 | CDC7 | 1.33070428 |
| 40 | CDK19 | 1.32593953 |
| 41 | CSF1R | 1.30247442 |
| 42 | CDK7 | 1.29173116 |
| 43 | IKBKB | 1.25447347 |
| 44 | TYK2 | 1.22604653 |
| 45 | CCNB1 | 1.21693842 |
| 46 | MATK | 1.21042986 |
| 47 | TXK | 1.19819281 |
| 48 | MST4 | 1.18900353 |
| 49 | SRPK1 | 1.17736033 |
| 50 | SYK | 1.16422488 |
| 51 | PRKG2 | 1.12520275 |
| 52 | PKN2 | 1.12321338 |
| 53 | EIF2AK3 | 1.08446152 |
| 54 | PIM1 | 1.06311251 |
| 55 | IKBKE | 1.06122580 |
| 56 | MAP2K6 | 1.03794221 |
| 57 | TSSK6 | 1.03252717 |
| 58 | LRRK2 | 1.03120265 |
| 59 | MAP3K11 | 0.99953407 |
| 60 | CAMKK2 | 0.99135623 |
| 61 | BLK | 0.99075673 |
| 62 | NEK2 | 0.98489807 |
| 63 | ARAF | 0.97738568 |
| 64 | SCYL2 | 0.97322067 |
| 65 | ITK | 0.96412306 |
| 66 | RPS6KA4 | 0.94839898 |
| 67 | MKNK2 | 0.92542501 |
| 68 | LYN | 0.92282090 |
| 69 | ATR | 0.89117085 |
| 70 | ABL2 | 0.88500929 |
| 71 | PASK | 0.88154552 |
| 72 | MAP3K12 | 0.87882367 |
| 73 | GRK5 | 0.86655573 |
| 74 | MYLK | 0.84645226 |
| 75 | CDK4 | 0.84079588 |
| 76 | BMX | 0.80651245 |
| 77 | TRPM7 | 0.80489412 |
| 78 | BCKDK | 0.79542656 |
| 79 | TLK1 | 0.77491776 |
| 80 | PTK2B | 0.76343453 |
| 81 | IRAK4 | 0.75917987 |
| 82 | BMPR2 | 0.72511184 |
| 83 | PAK4 | 0.72091986 |
| 84 | LCK | 0.72062537 |
| 85 | MAP3K1 | 0.71835062 |
| 86 | AURKB | 0.71589299 |
| 87 | ADRBK2 | 0.70719875 |
| 88 | ERN1 | 0.70351680 |
| 89 | CLK1 | 0.67635016 |
| 90 | STK10 | 0.65962099 |
| 91 | DAPK3 | 0.64926786 |
| 92 | ILK | 0.64470125 |
| 93 | FES | 0.63816877 |
| 94 | MAP3K6 | 0.62829170 |
| 95 | PLK4 | 0.61827465 |
| 96 | TESK1 | 0.61460762 |
| 97 | PRKCQ | 0.61262672 |
| 98 | EIF2AK2 | 0.60130433 |
| 99 | TAOK3 | 0.59660346 |
| 100 | MAPKAPK3 | 0.58279112 |
| 101 | MAPK12 | 0.56897828 |
| 102 | ADRBK1 | 0.55428008 |
| 103 | NLK | 0.53503965 |
| 104 | DAPK2 | 0.52425137 |
| 105 | STK4 | 0.52149086 |
| 106 | MAPK4 | 0.51410375 |
| 107 | CAMK1 | 0.49463459 |
| 108 | CDK9 | 0.49324924 |
| 109 | IRAK3 | 0.48581221 |
| 110 | RPS6KA5 | 0.48004769 |
| 111 | AURKA | 0.47494993 |
| 112 | PLK1 | 0.47225497 |
| 113 | MAP3K8 | 0.46978589 |
| 114 | HCK | 0.45575964 |
| 115 | TAOK2 | 0.43231319 |
| 116 | CSNK1G3 | 0.42489447 |
| 117 | CSNK2A1 | 0.42482786 |
| 118 | ZAK | 0.41715841 |
| 119 | BRSK1 | 0.41355687 |
| 120 | RPS6KC1 | 0.41184196 |
| 121 | RPS6KL1 | 0.41184196 |
| 122 | MAP3K5 | 0.41082379 |
| 123 | MAP2K7 | 0.39969572 |
| 124 | CDK3 | 0.39524547 |
| 125 | YES1 | 0.39450542 |
| 126 | TNK2 | 0.38967501 |
| 127 | RAF1 | 0.38584830 |
| 128 | MAPK11 | 0.37760251 |
| 129 | DAPK1 | 0.37354261 |
| 130 | HIPK2 | 0.36542091 |
| 131 | RIPK4 | 0.36471567 |
| 132 | RPS6KA6 | 0.36087012 |
| 133 | PIK3CG | 0.35773497 |
| 134 | MAP3K14 | 0.35258188 |
| 135 | PRKCD | 0.32096416 |
| 136 | IGF1R | 0.30605435 |
| 137 | MAPK3 | 0.29940272 |
| 138 | PAK1 | 0.28326526 |
| 139 | PAK2 | 0.28281595 |
| 140 | ABL1 | 0.27424903 |
| 141 | PLK2 | 0.26403073 |
| 142 | MAP3K3 | 0.25177468 |
| 143 | SMG1 | 0.23900094 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.02278780 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.47420132 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.55346752 |
| 4 | Asthma_Homo sapiens_hsa05310 | 3.54319099 |
| 5 | Base excision repair_Homo sapiens_hsa03410 | 2.94732677 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.93563672 |
| 7 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.66434840 |
| 8 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.64380073 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.61054970 |
| 10 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.48528340 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.40665611 |
| 12 | Spliceosome_Homo sapiens_hsa03040 | 2.37919916 |
| 13 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.28012651 |
| 14 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.23467682 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.20119265 |
| 16 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.15827056 |
| 17 | Proteasome_Homo sapiens_hsa03050 | 2.10275287 |
| 18 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.80489136 |
| 19 | Cell cycle_Homo sapiens_hsa04110 | 1.72973080 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.62656865 |
| 21 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.61957909 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.60091133 |
| 23 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.57605727 |
| 24 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.57046700 |
| 25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.55636723 |
| 26 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.48490254 |
| 27 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.39797821 |
| 28 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.37752178 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.36615141 |
| 30 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.36507766 |
| 31 | Viral myocarditis_Homo sapiens_hsa05416 | 1.32163151 |
| 32 | Basal transcription factors_Homo sapiens_hsa03022 | 1.31713803 |
| 33 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.31233971 |
| 34 | Platelet activation_Homo sapiens_hsa04611 | 1.31058442 |
| 35 | Protein export_Homo sapiens_hsa03060 | 1.30457590 |
| 36 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.29462752 |
| 37 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.28388882 |
| 38 | Measles_Homo sapiens_hsa05162 | 1.26854822 |
| 39 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.26184413 |
| 40 | Parkinsons disease_Homo sapiens_hsa05012 | 1.24640871 |
| 41 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.23880928 |
| 42 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.21228858 |
| 43 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.20832984 |
| 44 | Sulfur relay system_Homo sapiens_hsa04122 | 1.16965339 |
| 45 | Leishmaniasis_Homo sapiens_hsa05140 | 1.13891029 |
| 46 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.09889408 |
| 47 | Phototransduction_Homo sapiens_hsa04744 | 1.06481296 |
| 48 | Peroxisome_Homo sapiens_hsa04146 | 1.03429184 |
| 49 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.03390717 |
| 50 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.00941619 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.00147740 |
| 52 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.99977302 |
| 53 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.98957991 |
| 54 | Shigellosis_Homo sapiens_hsa05131 | 0.98810406 |
| 55 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.97533964 |
| 56 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.95987435 |
| 57 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.94371237 |
| 58 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.93235005 |
| 59 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.90287044 |
| 60 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.88664151 |
| 61 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.87242268 |
| 62 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.86204320 |
| 63 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.85051384 |
| 64 | Other glycan degradation_Homo sapiens_hsa00511 | 0.83324814 |
| 65 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.81484890 |
| 66 | Hepatitis B_Homo sapiens_hsa05161 | 0.80625682 |
| 67 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.79752643 |
| 68 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.78150306 |
| 69 | Legionellosis_Homo sapiens_hsa05134 | 0.76595596 |
| 70 | Influenza A_Homo sapiens_hsa05164 | 0.75280830 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.74472886 |
| 72 | Apoptosis_Homo sapiens_hsa04210 | 0.74223485 |
| 73 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.74096770 |
| 74 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.74020685 |
| 75 | Thyroid cancer_Homo sapiens_hsa05216 | 0.73758237 |
| 76 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.71852524 |
| 77 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.71819335 |
| 78 | Pertussis_Homo sapiens_hsa05133 | 0.70839294 |
| 79 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.70138602 |
| 80 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.69484623 |
| 81 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.68839125 |
| 82 | Malaria_Homo sapiens_hsa05144 | 0.68589373 |
| 83 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.67676126 |
| 84 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.66088463 |
| 85 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.65338864 |
| 86 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.63971504 |
| 87 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.63563949 |
| 88 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61530020 |
| 89 | Olfactory transduction_Homo sapiens_hsa04740 | 0.60904989 |
| 90 | HTLV-I infection_Homo sapiens_hsa05166 | 0.60858281 |
| 91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.59028820 |
| 92 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.55047633 |
| 93 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.54825937 |
| 94 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.53700506 |
| 95 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.52532671 |
| 96 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50968360 |
| 97 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.50748901 |
| 98 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.49976605 |
| 99 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.49196256 |
| 100 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48330299 |
| 101 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.47129645 |
| 102 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.45787071 |
| 103 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.45451578 |
| 104 | Salmonella infection_Homo sapiens_hsa05132 | 0.43437511 |
| 105 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.43377506 |
| 106 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43183133 |
| 107 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.43010384 |
| 108 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.42690819 |
| 109 | Huntingtons disease_Homo sapiens_hsa05016 | 0.41898921 |
| 110 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.41688655 |
| 111 | Alzheimers disease_Homo sapiens_hsa05010 | 0.40814742 |
| 112 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.39862232 |
| 113 | Phagosome_Homo sapiens_hsa04145 | 0.39215094 |
| 114 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.38781038 |
| 115 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.38617409 |
| 116 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.38441089 |
| 117 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.37095478 |
| 118 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.36716122 |
| 119 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.36494342 |
| 120 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35762468 |
| 121 | Allograft rejection_Homo sapiens_hsa05330 | 0.35248516 |
| 122 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.34056948 |
| 123 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.32618366 |
| 124 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.32319931 |
| 125 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.31870891 |
| 126 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.31125070 |
| 127 | Lysosome_Homo sapiens_hsa04142 | 0.29711343 |
| 128 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.29663149 |
| 129 | Alcoholism_Homo sapiens_hsa05034 | 0.29350206 |
| 130 | Galactose metabolism_Homo sapiens_hsa00052 | 0.29225244 |
| 131 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.29035908 |
| 132 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.27925211 |
| 133 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.27782047 |
| 134 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.26726932 |
| 135 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.26705971 |
| 136 | Pathways in cancer_Homo sapiens_hsa05200 | 0.26151150 |
| 137 | Tuberculosis_Homo sapiens_hsa05152 | 0.25820934 |
| 138 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.23454655 |
| 139 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.21855009 |
| 140 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.21764937 |

