FAM213B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.26724349
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.05644361
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.80191456
4ATP synthesis coupled proton transport (GO:0015986)4.80191456
5barbed-end actin filament capping (GO:0051016)4.68822229
6protein retention in ER lumen (GO:0006621)4.55384978
7respiratory electron transport chain (GO:0022904)4.45559856
8electron transport chain (GO:0022900)4.36286477
9protein localization to endosome (GO:0036010)4.25504418
10glycosphingolipid catabolic process (GO:0046479)4.20796511
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.16306902
12sensory perception of smell (GO:0007608)4.10411255
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.99641487
14regulation of early endosome to late endosome transport (GO:2000641)3.89804508
15neuronal action potential propagation (GO:0019227)3.77985138
16glycolipid catabolic process (GO:0019377)3.75720141
17neuron cell-cell adhesion (GO:0007158)3.73529795
18negative regulation of erythrocyte differentiation (GO:0045647)3.69582751
19fatty acid elongation (GO:0030497)3.66123839
20central nervous system myelination (GO:0022010)3.64170060
21axon ensheathment in central nervous system (GO:0032291)3.64170060
22G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.58155034
23cell-cell junction maintenance (GO:0045217)3.54737748
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.53656930
25semaphorin-plexin signaling pathway (GO:0071526)3.51277020
26synaptic vesicle exocytosis (GO:0016079)3.49953403
27Golgi transport vesicle coating (GO:0048200)3.45943951
28COPI coating of Golgi vesicle (GO:0048205)3.45943951
29glucose 6-phosphate metabolic process (GO:0051156)3.43416350
30proline biosynthetic process (GO:0006561)3.41223416
31long-chain fatty acid biosynthetic process (GO:0042759)3.40294679
32detection of calcium ion (GO:0005513)3.28980920
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27253280
34positive regulation of Cdc42 GTPase activity (GO:0043089)3.27148882
35adhesion of symbiont to host (GO:0044406)3.21076417
36regulation of cell communication by electrical coupling (GO:0010649)3.20803951
37regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.19051292
38ATP hydrolysis coupled proton transport (GO:0015991)3.14567690
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14567690
40virion attachment to host cell (GO:0019062)3.13556591
41adhesion of symbiont to host cell (GO:0044650)3.13556591
42activation of Rac GTPase activity (GO:0032863)3.13037728
43positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11333050
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.08210141
45vocalization behavior (GO:0071625)3.07908405
46sodium ion export (GO:0071436)3.06544809
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04141160
48calcium-mediated signaling using intracellular calcium source (GO:0035584)3.02740791
49regulation of cholesterol homeostasis (GO:2000188)3.02435805
50ceramide catabolic process (GO:0046514)3.01947094
51angiotensin maturation (GO:0002003)3.01148313
52hydrogen ion transmembrane transport (GO:1902600)2.98410065
53regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97701173
54epithelial cell-cell adhesion (GO:0090136)2.97257344
55endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.96441832
56substantia nigra development (GO:0021762)2.94027005
57stress fiber assembly (GO:0043149)2.92964088
58glutamate secretion (GO:0014047)2.92809502
59regulation of synaptic vesicle exocytosis (GO:2000300)2.92476669
60presynaptic membrane assembly (GO:0097105)2.92287619
61activation of MAPKKK activity (GO:0000185)2.88252379
62amino sugar catabolic process (GO:0046348)2.87509204
63regulation of cholesterol biosynthetic process (GO:0045540)2.84774530
64regulation of extracellular matrix disassembly (GO:0010715)2.84242943
65positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.83923788
66modulation by symbiont of host cellular process (GO:0044068)2.83372932
67regulation of cholesterol storage (GO:0010885)2.83053256
68response to acidic pH (GO:0010447)2.82820470
69sphingolipid catabolic process (GO:0030149)2.82619039
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82412617
71dopamine receptor signaling pathway (GO:0007212)2.82028518
72signal complex assembly (GO:0007172)2.82009815
73behavioral response to cocaine (GO:0048148)2.80171495
74ATP biosynthetic process (GO:0006754)2.79667852
75presynaptic membrane organization (GO:0097090)2.79257887
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.77342041
77layer formation in cerebral cortex (GO:0021819)2.76177281
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73429109
79protein localization to synapse (GO:0035418)2.73336396
80negative regulation of cell size (GO:0045792)2.72776884
81protein localization to cilium (GO:0061512)2.72381788
82mannose metabolic process (GO:0006013)2.71527415
83modulation by virus of host process (GO:0019054)2.70197731
84proton transport (GO:0015992)2.69857967
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69433823
86positive regulation of synapse maturation (GO:0090129)2.69158849
87transmission of nerve impulse (GO:0019226)2.68514505
88adenosine receptor signaling pathway (GO:0001973)2.68440008
89membrane lipid catabolic process (GO:0046466)2.68391601
90epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68025869
91cellular response to epinephrine stimulus (GO:0071872)2.67252703
92neuron recognition (GO:0008038)2.66842546
93hydrogen transport (GO:0006818)2.66554011
94apoptotic process involved in morphogenesis (GO:0060561)2.64647046
95creatine metabolic process (GO:0006600)2.63606357
96pinocytosis (GO:0006907)2.63575147
97regulation of superoxide anion generation (GO:0032928)2.62806035
98response to epinephrine (GO:0071871)2.62617150
99pentose-phosphate shunt (GO:0006098)2.62357885
100regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.61890993
101transferrin transport (GO:0033572)2.61638355
102regulation of defense response to virus by virus (GO:0050690)2.61506702
103fat-soluble vitamin biosynthetic process (GO:0042362)2.61402311
104cellular response to prostaglandin stimulus (GO:0071379)2.60386016
105modulation by virus of host morphology or physiology (GO:0019048)2.59507171
106chaperone-mediated protein transport (GO:0072321)2.59321650
107amyloid precursor protein catabolic process (GO:0042987)2.58457669
108glucose catabolic process (GO:0006007)2.58278742
109regulation of synaptic vesicle transport (GO:1902803)2.58129258
110regulation of voltage-gated calcium channel activity (GO:1901385)2.57889643
111regulation of ARF protein signal transduction (GO:0032012)2.57857598
112regulation of podosome assembly (GO:0071801)2.57735729
113peptidyl-tyrosine autophosphorylation (GO:0038083)2.56848132
114endothelial cell chemotaxis (GO:0035767)2.56557877
115protein maturation by protein folding (GO:0022417)2.56514526
116gamma-aminobutyric acid signaling pathway (GO:0007214)2.55700179
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55546020
118negative regulation of neurotransmitter transport (GO:0051589)2.54942173
119positive regulation of pseudopodium assembly (GO:0031274)2.54857459
120regulation of synapse structural plasticity (GO:0051823)2.54699587
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.53869714
122regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53722289
123proline metabolic process (GO:0006560)2.53092966
124UV protection (GO:0009650)2.53029760
125positive regulation of receptor recycling (GO:0001921)2.52898064
126regulation of protein kinase A signaling (GO:0010738)2.52011324
127neuromuscular process controlling posture (GO:0050884)2.51800826
128sensory perception of chemical stimulus (GO:0007606)2.50067437
129oligosaccharide catabolic process (GO:0009313)2.48343188
130adherens junction assembly (GO:0034333)2.47452836
131trivalent inorganic cation transport (GO:0072512)2.47426220
132ferric iron transport (GO:0015682)2.47426220
133regulation of acyl-CoA biosynthetic process (GO:0050812)2.47008222
134neurotransmitter secretion (GO:0007269)2.46033342
135cell junction maintenance (GO:0034331)2.45924137
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45373572
137negative regulation of protein localization to cell surface (GO:2000009)2.44412823
138glutathione biosynthetic process (GO:0006750)2.43803593
139N-acetylneuraminate metabolic process (GO:0006054)2.43071387
140regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.42965481
141NIK/NF-kappaB signaling (GO:0038061)2.41885428
142regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.41490903
143cellular response to thyroid hormone stimulus (GO:0097067)2.41473212
144regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.41376641
145purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.41020605
146regulation of glutamate receptor signaling pathway (GO:1900449)2.40967125
147long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.40930647
148protein neddylation (GO:0045116)2.40507849
149regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.40065545
150actin filament bundle assembly (GO:0051017)2.39665847
151actin filament bundle organization (GO:0061572)2.39665847
152basement membrane organization (GO:0071711)2.39583836
153regulation of extracellular matrix organization (GO:1903053)2.39543021
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39436242
155axonal fasciculation (GO:0007413)2.38920959
156mating behavior (GO:0007617)2.38831753
157myelination (GO:0042552)2.38295375
158neurotransmitter catabolic process (GO:0042135)2.37850960
159regulation of glutamate secretion (GO:0014048)2.37635346
160regulation of cholesterol metabolic process (GO:0090181)2.37610400
161female mating behavior (GO:0060180)2.37084767
162cell volume homeostasis (GO:0006884)2.36822224
163activation of protein kinase A activity (GO:0034199)2.36587317
164neuron-neuron synaptic transmission (GO:0007270)2.36189612
165tricarboxylic acid cycle (GO:0006099)2.35842277
166bone resorption (GO:0045453)2.35595374
167regulation of vesicle fusion (GO:0031338)2.35519598
168positive regulation of neurotransmitter secretion (GO:0001956)2.35419307
169neurotransmitter transport (GO:0006836)2.35414943
170regulation of protein dephosphorylation (GO:0035304)2.35289896
171purine nucleoside triphosphate biosynthetic process (GO:0009145)2.34777177
172adult walking behavior (GO:0007628)2.34152922
173axon ensheathment (GO:0008366)2.34010015
174ensheathment of neurons (GO:0007272)2.34010015
175receptor catabolic process (GO:0032801)2.33338850
176apoptotic cell clearance (GO:0043277)2.32116945
177glutamate receptor signaling pathway (GO:0007215)2.32061853
178synaptic vesicle maturation (GO:0016188)2.31413293
179amino acid import (GO:0043090)2.31317910
180fatty-acyl-CoA metabolic process (GO:0035337)2.31147174
181regulation of collateral sprouting (GO:0048670)2.31065388
182receptor recycling (GO:0001881)2.31058559
183negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.30425601
184neurotransmitter uptake (GO:0001504)2.30307736
185negative regulation of synaptic transmission, GABAergic (GO:0032229)2.29160056
186NADH metabolic process (GO:0006734)2.28896901
187membrane hyperpolarization (GO:0060081)2.28870472
188inner mitochondrial membrane organization (GO:0007007)2.28107055
189multicellular organismal signaling (GO:0035637)2.27566328
190positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27555437
191negative regulation of neurotransmitter secretion (GO:0046929)2.27128029
192nonribosomal peptide biosynthetic process (GO:0019184)2.25481340
193neuronal action potential (GO:0019228)2.24598158
194cerebellar granule cell differentiation (GO:0021707)2.24022838
195regulation of neuronal synaptic plasticity (GO:0048168)2.23808868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09708641
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66944925
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.17979164
4GBX2_23144817_ChIP-Seq_PC3_Human3.14812960
5LXR_22292898_ChIP-Seq_THP-1_Human3.12837373
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.96449653
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89091076
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71006519
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67130962
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56005455
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.50991542
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42323044
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40746635
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32585668
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31957619
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31957619
17VDR_21846776_ChIP-Seq_THP-1_Human2.31328539
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27173268
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27039266
20TAF15_26573619_Chip-Seq_HEK293_Human2.26895226
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25495649
22RACK7_27058665_Chip-Seq_MCF-7_Human2.25401653
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24966297
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.23532609
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22502655
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22236348
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.22080543
28SRY_22984422_ChIP-ChIP_TESTIS_Rat2.17543280
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10514859
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05623409
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02067509
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99662926
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.98910211
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.98752440
35KDM2B_26808549_Chip-Seq_K562_Human1.97506777
36REST_21632747_ChIP-Seq_MESCs_Mouse1.96207472
37ZNF263_19887448_ChIP-Seq_K562_Human1.92328407
38MYC_22102868_ChIP-Seq_BL_Human1.90016930
39VDR_22108803_ChIP-Seq_LS180_Human1.89759442
40KDM2B_26808549_Chip-Seq_DND41_Human1.89183273
41DROSHA_22980978_ChIP-Seq_HELA_Human1.88523643
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.86936504
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79990901
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.79725286
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75782121
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74715069
47TCF7_22412390_ChIP-Seq_EML_Mouse1.74010504
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72358751
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.71761573
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70276766
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.69579201
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68806592
53P68_20966046_ChIP-Seq_HELA_Human1.68552056
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67777410
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66257056
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65459631
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.64536873
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.63298983
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61978798
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.59581434
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.58156602
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58085498
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56394437
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56383815
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55128663
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52519082
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52000374
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48704525
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48618392
70SMC4_20622854_ChIP-Seq_HELA_Human1.44911812
71P300_19829295_ChIP-Seq_ESCs_Human1.44199582
72CREB1_26743006_Chip-Seq_LNCaP_Human1.40344644
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.38869769
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37052069
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36509056
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35740518
77SMAD4_21799915_ChIP-Seq_A2780_Human1.34838447
78AR_21572438_ChIP-Seq_LNCaP_Human1.34658104
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.34086391
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33755589
81VDR_24763502_ChIP-Seq_THP-1_Human1.32057770
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31602580
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31097347
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30935630
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.29924575
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29425411
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.29193524
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29157300
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29018463
90CLOCK_20551151_ChIP-Seq_293T_Human1.28368461
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28136206
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28087177
93BCL6_27268052_Chip-Seq_Bcells_Human1.27213938
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.26844127
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.24986898
96ER_23166858_ChIP-Seq_MCF-7_Human1.24546477
97BCOR_27268052_Chip-Seq_Bcells_Human1.23929379
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22726613
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21603735
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19650332
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19508793
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17767544
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17218747
104TP53_22127205_ChIP-Seq_IMR90_Human1.16861812
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16382975
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16044000
107SA1_27219007_Chip-Seq_Bcells_Human1.14092720
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13961130
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.12811088
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12533711
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11850101
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11642893
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11309558
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10852922
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10669312
116IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09778829
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09628887
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09417350
119ATF3_27146783_Chip-Seq_COLON_Human1.08803324
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08445725
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06972932
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06219823
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06017093
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05962743
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05750372
126ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05521601
127CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05201216
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05184760
129ZNF274_21170338_ChIP-Seq_K562_Hela1.04828805
130RNF2_27304074_Chip-Seq_NSC_Mouse1.03668779
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03369322
132GATA1_19941827_ChIP-Seq_MEL_Mouse1.03351927
133RUNX1_22412390_ChIP-Seq_EML_Mouse1.03254823
134FUS_26573619_Chip-Seq_HEK293_Human1.02369429
135MAF_26560356_Chip-Seq_TH1_Human1.01989684
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01559709
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00958213
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00848145
139NCOR1_26117541_ChIP-Seq_K562_Human1.00827982
140CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00753040
141JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00642537
142CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00574021
143SOX2_21211035_ChIP-Seq_LN229_Gbm1.00187322
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99962668
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99349369
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.99294067
147PHF8_20622854_ChIP-Seq_HELA_Human0.99223254
148TP63_22573176_ChIP-Seq_HFKS_Human0.98546965
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.98366797
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97911628
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.97908938
152HTT_18923047_ChIP-ChIP_STHdh_Human0.97793734
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97679212
154MAF_26560356_Chip-Seq_TH2_Human0.97667328
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97520582
156EP300_21415370_ChIP-Seq_HL-1_Mouse0.97242532
157PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95904809
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95786725
159RUNX1_27514584_Chip-Seq_MCF-7_Human0.95669485
160AR_25329375_ChIP-Seq_VCAP_Human0.95489888
161RING1B_27294783_Chip-Seq_ESCs_Mouse0.93076580
162AHR_22903824_ChIP-Seq_MCF-7_Human0.91121054
163P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90910725
164BCAT_22108803_ChIP-Seq_LS180_Human0.90642658
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.90332016
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90137215
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89981038
168CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87765322
169SOX2_19829295_ChIP-Seq_ESCs_Human0.87127330
170NANOG_19829295_ChIP-Seq_ESCs_Human0.87127330
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.87021727
172STAT3_23295773_ChIP-Seq_U87_Human0.85710435
173PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85601363
174NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85162931
175NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85162931
176FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84546152
177ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83705924
178SMAD4_21741376_ChIP-Seq_EPCs_Human0.83382752
179RUNX2_22187159_ChIP-Seq_PCA_Human0.83013739
180CTCF_27219007_Chip-Seq_Bcells_Human0.81975484
181GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81540165
182CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81465445
183ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79860330
184TCF4_23295773_ChIP-Seq_U87_Human0.78819030
185AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77820034
186E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.77299354
187TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77137025
188JUN_21703547_ChIP-Seq_K562_Human0.76897645
189POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76794921
190TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76794921
191SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76763010
192NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76551068
193RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.76459130
194TP53_18474530_ChIP-ChIP_U2OS_Human0.75846062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.87028428
2MP0003880_abnormal_central_pattern4.31117881
3MP0001984_abnormal_olfaction3.95908779
4MP0009840_abnormal_foam_cell3.56096816
5MP0002837_dystrophic_cardiac_calcinosis3.29136321
6MP0004859_abnormal_synaptic_plasticity3.22062051
7MP0003705_abnormal_hypodermis_morpholog3.10962620
8MP0010234_abnormal_vibrissa_follicle3.08543286
9MP0005257_abnormal_intraocular_pressure2.90715594
10MP0003172_abnormal_lysosome_physiology2.90465554
11MP0004270_analgesia2.85700686
12MP0001849_ear_inflammation2.73899265
13MP0003635_abnormal_synaptic_transmissio2.65967361
14MP0009046_muscle_twitch2.64959601
15MP0002064_seizures2.54215513
16MP0003303_peritoneal_inflammation2.45846277
17MP0002272_abnormal_nervous_system2.43445387
18MP0003183_abnormal_peptide_metabolism2.41009529
19MP0003123_paternal_imprinting2.39493090
20MP0009745_abnormal_behavioral_response2.38756556
21MP0000751_myopathy2.31840555
22MP0001529_abnormal_vocalization2.25550359
23MP0008260_abnormal_autophagy2.15708273
24MP0005360_urolithiasis2.13574233
25MP0002063_abnormal_learning/memory/cond2.12925763
26MP0002734_abnormal_mechanical_nocicepti2.11338201
27MP0003191_abnormal_cellular_cholesterol2.07805836
28MP0002139_abnormal_hepatobiliary_system2.07654519
29MP0002822_catalepsy2.06398929
30MP0001486_abnormal_startle_reflex2.04392729
31MP0002572_abnormal_emotion/affect_behav2.01292292
32MP0004145_abnormal_muscle_electrophysio2.01103248
33MP0003075_altered_response_to1.99530442
34MP0001968_abnormal_touch/_nociception1.96457919
35MP0006276_abnormal_autonomic_nervous1.93101327
36MP0009278_abnormal_bone_marrow1.89229443
37MP0001440_abnormal_grooming_behavior1.89195111
38MP0001501_abnormal_sleep_pattern1.83050801
39MP0004510_myositis1.81256012
40MP0003329_amyloid_beta_deposits1.80088447
41MP0003453_abnormal_keratinocyte_physiol1.76491793
42MP0003646_muscle_fatigue1.74697616
43MP0001905_abnormal_dopamine_level1.70292693
44MP0002876_abnormal_thyroid_physiology1.67367001
45MP0004142_abnormal_muscle_tone1.66766304
46MP0000678_abnormal_parathyroid_gland1.66714554
47MP0002736_abnormal_nociception_after1.65726311
48MP0002067_abnormal_sensory_capabilities1.65434422
49MP0000920_abnormal_myelination1.63581053
50MP0003436_decreased_susceptibility_to1.63263494
51MP0002184_abnormal_innervation1.62857486
52MP0002735_abnormal_chemical_nociception1.61679416
53MP0004036_abnormal_muscle_relaxation1.59483618
54MP0002089_abnormal_postnatal_growth/wei1.56445012
55MP0000537_abnormal_urethra_morphology1.54925116
56MP0001970_abnormal_pain_threshold1.52635079
57MP0004215_abnormal_myocardial_fiber1.52584469
58MP0004924_abnormal_behavior1.51057115
59MP0005386_behavior/neurological_phenoty1.51057115
60MP0002653_abnormal_ependyma_morphology1.50517374
61MP0009379_abnormal_foot_pigmentation1.50064788
62MP0000566_synostosis1.47238971
63MP0002733_abnormal_thermal_nociception1.46502039
64MP0005423_abnormal_somatic_nervous1.43380359
65MP0000858_altered_metastatic_potential1.43009883
66MP0003566_abnormal_cell_adhesion1.41785732
67MP0000749_muscle_degeneration1.40210179
68MP0005645_abnormal_hypothalamus_physiol1.40174059
69MP0000778_abnormal_nervous_system1.38078931
70MP0000490_abnormal_crypts_of1.35518308
71MP0004264_abnormal_extraembryonic_tissu1.35489603
72MP0003300_gastrointestinal_ulcer1.34579557
73MP0003879_abnormal_hair_cell1.33004625
74MP0002909_abnormal_adrenal_gland1.29616280
75MP0002557_abnormal_social/conspecific_i1.27333258
76MP0002229_neurodegeneration1.26674135
77MP0000747_muscle_weakness1.26009957
78MP0004742_abnormal_vestibular_system1.25686251
79MP0002998_abnormal_bone_remodeling1.25378908
80MP0003690_abnormal_glial_cell1.23899108
81MP0002066_abnormal_motor_capabilities/c1.22518284
82MP0008569_lethality_at_weaning1.22072367
83MP0002249_abnormal_larynx_morphology1.20624311
84MP0005076_abnormal_cell_differentiation1.20339629
85MP0002882_abnormal_neuron_morphology1.19836375
86MP0010030_abnormal_orbit_morphology1.18128713
87MP0004185_abnormal_adipocyte_glucose1.18087857
88MP0002796_impaired_skin_barrier1.17164585
89MP0010386_abnormal_urinary_bladder1.16687379
90MP0000343_altered_response_to1.16482720
91MP0006036_abnormal_mitochondrial_physio1.15868252
92MP0010155_abnormal_intestine_physiology1.15523094
93MP0004947_skin_inflammation1.14346102
94MP0005365_abnormal_bile_salt1.14231601
95MP0005166_decreased_susceptibility_to1.13890576
96MP0000013_abnormal_adipose_tissue1.13796213
97MP0004381_abnormal_hair_follicle1.12074589
98MP0004043_abnormal_pH_regulation1.12042111
99MP0003634_abnormal_glial_cell1.11599658
100MP0005551_abnormal_eye_electrophysiolog1.11084010
101MP0001485_abnormal_pinna_reflex1.10156279
102MP0005501_abnormal_skin_physiology1.10082297
103MP0005646_abnormal_pituitary_gland1.07685490
104MP0005620_abnormal_muscle_contractility1.07350219
105MP0005464_abnormal_platelet_physiology1.07232745
106MP0005409_darkened_coat_color1.06366028
107MP0004484_altered_response_of1.05158692
108MP0003091_abnormal_cell_migration1.04135261
109MP0005535_abnormal_body_temperature1.03739403
110MP0003137_abnormal_impulse_conducting1.03699307
111MP0003195_calcinosis1.03668058
112MP0000955_abnormal_spinal_cord1.03043175
113MP0008874_decreased_physiological_sensi1.02726324
114MP0006035_abnormal_mitochondrial_morpho0.98673102
115MP0001533_abnormal_skeleton_physiology0.98487464
116MP0004130_abnormal_muscle_cell0.98110006
117MP0004019_abnormal_vitamin_homeostasis0.97162735
118MP0009333_abnormal_splenocyte_physiolog0.96232646
119MP0004085_abnormal_heartbeat0.96172123
120MP0005330_cardiomyopathy0.94690498
121MP0003633_abnormal_nervous_system0.94511138
122MP0001963_abnormal_hearing_physiology0.91906529
123MP0002877_abnormal_melanocyte_morpholog0.91875025
124MP0002752_abnormal_somatic_nervous0.91185786
125MP0001502_abnormal_circadian_rhythm0.90245239
126MP0003631_nervous_system_phenotype0.88171883
127MP0004084_abnormal_cardiac_muscle0.87700751
128MP0004885_abnormal_endolymph0.87311706
129MP0004811_abnormal_neuron_physiology0.86891475
130MP0006082_CNS_inflammation0.86662879
131MP0005451_abnormal_body_composition0.86157204
132MP0002896_abnormal_bone_mineralization0.86025731
133MP0002106_abnormal_muscle_physiology0.85459175
134MP0005666_abnormal_adipose_tissue0.84857227
135MP0002090_abnormal_vision0.84345027
136MP0002332_abnormal_exercise_endurance0.84089466
137MP0001663_abnormal_digestive_system0.83685511
138MP0009780_abnormal_chondrocyte_physiolo0.82716938
139MP0003279_aneurysm0.82470933
140MP0005369_muscle_phenotype0.80279807
141MP0003878_abnormal_ear_physiology0.79728988
142MP0005377_hearing/vestibular/ear_phenot0.79728988
143MP0000477_abnormal_intestine_morphology0.79116049
144MP0000604_amyloidosis0.78979985
145MP0004233_abnormal_muscle_weight0.78979430
146MP0005167_abnormal_blood-brain_barrier0.78464343
147MP0002972_abnormal_cardiac_muscle0.78160744
148MP0001664_abnormal_digestion0.77506575
149MP0005381_digestive/alimentary_phenotyp0.77299960
150MP0001188_hyperpigmentation0.77216731
151MP0002098_abnormal_vibrissa_morphology0.76266261
152MP0008875_abnormal_xenobiotic_pharmacok0.75527527
153MP0003866_abnormal_defecation0.74870855
154MP0005025_abnormal_response_to0.74662359
155MP0002069_abnormal_eating/drinking_beha0.73750836
156MP0005499_abnormal_olfactory_system0.72645380
157MP0005394_taste/olfaction_phenotype0.72645380
158MP0003632_abnormal_nervous_system0.72603912
159MP0001727_abnormal_embryo_implantation0.72168538
160MP0005390_skeleton_phenotype0.71860160
161MP0004858_abnormal_nervous_system0.71542113
162MP0000681_abnormal_thyroid_gland0.71412411
163MP0005375_adipose_tissue_phenotype0.70111188
164MP0000759_abnormal_skeletal_muscle0.70089912
165MP0003806_abnormal_nucleotide_metabolis0.69940434
166MP0002152_abnormal_brain_morphology0.68433461
167MP0005310_abnormal_salivary_gland0.67426385
168MP0002419_abnormal_innate_immunity0.65920689
169MP0005023_abnormal_wound_healing0.63617399
170MP0002148_abnormal_hypersensitivity_rea0.63087409
171MP0000015_abnormal_ear_pigmentation0.62991700
172MP0003448_altered_tumor_morphology0.62925605
173MP0005165_increased_susceptibility_to0.59921865
174MP0001666_abnormal_nutrient_absorption0.59615590
175MP0004272_abnormal_basement_membrane0.59159129
176MP0000003_abnormal_adipose_tissue0.55678862
177MP0005508_abnormal_skeleton_morphology0.53955567
178MP0002254_reproductive_system_inflammat0.53799989
179MP0001216_abnormal_epidermal_layer0.51405324
180MP0010368_abnormal_lymphatic_system0.51144373

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.90951675
2Abnormal mitochondria in muscle tissue (HP:0008316)4.58031048
3Focal motor seizures (HP:0011153)4.43919192
4Acute encephalopathy (HP:0006846)4.25798111
5Progressive macrocephaly (HP:0004481)4.17961637
6Mitochondrial inheritance (HP:0001427)4.05142679
7Myokymia (HP:0002411)4.03861674
8Dysostosis multiplex (HP:0000943)3.80316901
9Increased cerebral lipofuscin (HP:0011813)3.79144993
10Atonic seizures (HP:0010819)3.78746553
11Hepatocellular necrosis (HP:0001404)3.53536064
12Distal upper limb amyotrophy (HP:0007149)3.46797050
13Upper limb amyotrophy (HP:0009129)3.46797050
14Increased CSF lactate (HP:0002490)3.41830343
15Muscle hypertrophy of the lower extremities (HP:0008968)3.35957873
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.26009983
17Axonal loss (HP:0003447)3.17882126
18Exercise-induced myalgia (HP:0003738)3.15961974
19Hepatic necrosis (HP:0002605)3.15776734
20Hyperacusis (HP:0010780)3.11789081
21Pheochromocytoma (HP:0002666)3.08256705
22Absence seizures (HP:0002121)3.06511803
23Cerebral edema (HP:0002181)3.05326262
24Calf muscle hypertrophy (HP:0008981)3.02668567
25Focal seizures (HP:0007359)3.01890322
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01117759
27Systemic lupus erythematosus (HP:0002725)2.99601463
28Neuronal loss in central nervous system (HP:0002529)2.97536256
29Loss of speech (HP:0002371)2.96943896
30Hand muscle atrophy (HP:0009130)2.94600636
31Achilles tendon contracture (HP:0001771)2.92883449
32Retinal dysplasia (HP:0007973)2.88115896
33Sudden death (HP:0001699)2.84782363
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83994528
35Abnormality of polysaccharide metabolism (HP:0011012)2.83994528
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83994528
37Dialeptic seizures (HP:0011146)2.81033162
38Mucopolysacchariduria (HP:0008155)2.78835983
39Urinary glycosaminoglycan excretion (HP:0003541)2.78835983
40Neuroendocrine neoplasm (HP:0100634)2.77786438
41Apathy (HP:0000741)2.75513387
42Abnormality of glycolysis (HP:0004366)2.75352640
43Increased serum pyruvate (HP:0003542)2.75352640
44Vertebral compression fractures (HP:0002953)2.74477018
45J-shaped sella turcica (HP:0002680)2.73053819
46Visual hallucinations (HP:0002367)2.72654564
47Leukodystrophy (HP:0002415)2.69513956
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.68507800
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.68507800
50Diminished motivation (HP:0000745)2.67788526
51Obstructive sleep apnea (HP:0002870)2.65019767
52Neurofibrillary tangles (HP:0002185)2.64660656
53Optic disc pallor (HP:0000543)2.63106466
54Abnormality of the Achilles tendon (HP:0005109)2.62336204
55Epileptic encephalopathy (HP:0200134)2.61900738
56Insomnia (HP:0100785)2.59177930
57Nuclear cataract (HP:0100018)2.58843054
58Febrile seizures (HP:0002373)2.57607297
59Parakeratosis (HP:0001036)2.57305299
60Generalized tonic-clonic seizures (HP:0002069)2.56486972
61Respiratory failure (HP:0002878)2.55452842
62Distal lower limb amyotrophy (HP:0008944)2.53420587
63Thin bony cortex (HP:0002753)2.52362277
64Muscle fiber splitting (HP:0003555)2.51061287
65Renal Fanconi syndrome (HP:0001994)2.50729851
66Hyperventilation (HP:0002883)2.50022521
67Increased intramyocellular lipid droplets (HP:0012240)2.49126943
68Palpitations (HP:0001962)2.48911399
69Increased hepatocellular lipid droplets (HP:0006565)2.48664740
70Thoracic kyphosis (HP:0002942)2.48607452
71Lactic acidosis (HP:0003128)2.47257010
72Hyperparathyroidism (HP:0000843)2.45874879
73Vacuolated lymphocytes (HP:0001922)2.45841347
74Hemorrhage of the eye (HP:0011885)2.43390704
75Sensory axonal neuropathy (HP:0003390)2.41559268
76Lipid accumulation in hepatocytes (HP:0006561)2.39864727
77Exercise intolerance (HP:0003546)2.37639575
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36711576
79Increased muscle lipid content (HP:0009058)2.32475866
80Congenital ichthyosiform erythroderma (HP:0007431)2.32339592
81Purpura (HP:0000979)2.32284911
82Flat acetabular roof (HP:0003180)2.31031829
83Syncope (HP:0001279)2.29689205
84Cerebral inclusion bodies (HP:0100314)2.26211342
85Abnormality of the thoracic spine (HP:0100711)2.25893239
86Hyporeflexia of lower limbs (HP:0002600)2.21115018
87Cholecystitis (HP:0001082)2.19931541
88Abnormal gallbladder physiology (HP:0012438)2.19931541
89Termporal pattern (HP:0011008)2.17841169
90Insidious onset (HP:0003587)2.17841169
91Protrusio acetabuli (HP:0003179)2.16186198
92Mutism (HP:0002300)2.15827248
93Limb dystonia (HP:0002451)2.14883310
94Dementia (HP:0000726)2.14823629
95Growth hormone excess (HP:0000845)2.14373601
96Myotonia (HP:0002486)2.14019478
97Supranuclear gaze palsy (HP:0000605)2.13253385
98Anxiety (HP:0000739)2.12377519
99Abnormality of the calf musculature (HP:0001430)2.10914687
100Abnormality of the corticospinal tract (HP:0002492)2.10098698
101Lower limb amyotrophy (HP:0007210)2.09182168
102Muscle stiffness (HP:0003552)2.06390315
103Prolonged neonatal jaundice (HP:0006579)2.04250954
104Exercise-induced muscle cramps (HP:0003710)2.02805886
105Pathologic fracture (HP:0002756)2.02770599
106Progressive cerebellar ataxia (HP:0002073)2.02366373
107Ventricular fibrillation (HP:0001663)2.01120188
108Upper motor neuron abnormality (HP:0002127)1.99516070
109X-linked dominant inheritance (HP:0001423)1.99024015
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98802422
111Annular pancreas (HP:0001734)1.97722529
112Dysmetria (HP:0001310)1.97503489
113Septate vagina (HP:0001153)1.96379046
114Gait imbalance (HP:0002141)1.96147078
115Cerebral aneurysm (HP:0004944)1.95624362
116Central scotoma (HP:0000603)1.92892838
117Distal lower limb muscle weakness (HP:0009053)1.92599170
118Vaginal atresia (HP:0000148)1.91423885
119Premature rupture of membranes (HP:0001788)1.90933802
120Cerebral hemorrhage (HP:0001342)1.90783913
121Prolonged QT interval (HP:0001657)1.90777132
122Medial flaring of the eyebrow (HP:0010747)1.89469184
123Bone pain (HP:0002653)1.89155145
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88577524
125Long palpebral fissure (HP:0000637)1.88419317
126Myoglobinuria (HP:0002913)1.87954257
127Abnormality of the nasal mucosa (HP:0000433)1.86076964
128Xanthomatosis (HP:0000991)1.85024187
129Deep venous thrombosis (HP:0002625)1.84532194
130Genital tract atresia (HP:0001827)1.83098037
131Congenital primary aphakia (HP:0007707)1.83033319
132Turricephaly (HP:0000262)1.82794334
133Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82741866
134Polygenic inheritance (HP:0010982)1.82368454
135Cervical subluxation (HP:0003308)1.82190940
136Peripheral hypomyelination (HP:0007182)1.82129076
137Paralysis (HP:0003470)1.80411880
138Ankle clonus (HP:0011448)1.80292176
139Abdominal distention (HP:0003270)1.80182781
140Flattened epiphyses (HP:0003071)1.80066388
141Broad-based gait (HP:0002136)1.79786760
142Segmental peripheral demyelination/remyelination (HP:0003481)1.78973457
143Short nail (HP:0001799)1.78560839
144Athetosis (HP:0002305)1.77219355
145Pointed chin (HP:0000307)1.76801609
146Action tremor (HP:0002345)1.76024188
147Ketoacidosis (HP:0001993)1.75215433
148Abnormal eating behavior (HP:0100738)1.74938152
149Muscle fiber inclusion bodies (HP:0100299)1.74723005
150Lethargy (HP:0001254)1.74659360
151Methylmalonic aciduria (HP:0012120)1.74058064
152Centrally nucleated skeletal muscle fibers (HP:0003687)1.73845639
153Disinhibition (HP:0000734)1.73624967
154Multiple lipomas (HP:0001012)1.73173329
155Increased serum lactate (HP:0002151)1.73053539
156EMG: myopathic abnormalities (HP:0003458)1.73006601
157Methylmalonic acidemia (HP:0002912)1.72946836
158Intention tremor (HP:0002080)1.72571561
159Personality changes (HP:0000751)1.72062528
160CNS demyelination (HP:0007305)1.71439798
161Abnormality of renal resorption (HP:0011038)1.70925896
162Abnormality of liposaccharide metabolism (HP:0010968)1.70551020
163Abnormality of glycosphingolipid metabolism (HP:0004343)1.70551020
164Abnormality of glycolipid metabolism (HP:0010969)1.70551020
165Mitral regurgitation (HP:0001653)1.70090695
166Delusions (HP:0000746)1.70001469
167Paraparesis (HP:0002385)1.69177055
168Nephrogenic diabetes insipidus (HP:0009806)1.69050711
169Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68800867
170Hypertensive crisis (HP:0100735)1.68790285
171Spastic gait (HP:0002064)1.68408219
172Emotional lability (HP:0000712)1.67157110
173Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.66817503
174Disproportionate tall stature (HP:0001519)1.66741522
175Rapidly progressive (HP:0003678)1.66686515
176Abnormality of macrophages (HP:0004311)1.64350859
177Hypercalcemia (HP:0003072)1.64016790
178Stridor (HP:0010307)1.63277793
179Broad distal phalanx of finger (HP:0009836)1.60855951
180Overriding aorta (HP:0002623)1.60766429
181Slow saccadic eye movements (HP:0000514)1.60094921
182Hypophosphatemia (HP:0002148)1.59407788
183Urinary incontinence (HP:0000020)1.57366187
184Elfin facies (HP:0004428)1.56780150
185Bronchomalacia (HP:0002780)1.56779205
186Broad face (HP:0000283)1.56627146
187Distal sensory impairment (HP:0002936)1.55885517
188Neonatal death (HP:0003811)1.55776524
189Lower limb asymmetry (HP:0100559)1.55069561
190Gastrointestinal dysmotility (HP:0002579)1.54676389
191Joint stiffness (HP:0001387)1.53697465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.33091891
2CASK3.27215995
3STK393.18922932
4SIK12.89104121
5IRAK32.88108914
6ERN12.78771569
7MAP3K112.64335219
8OXSR12.62614906
9ARAF2.55511274
10PHKG22.48343656
11PHKG12.48343656
12TESK12.47501134
13RIPK12.46051527
14EPHA42.39134038
15NTRK32.35817535
16SMG12.33201902
17NME22.29574208
18ICK2.25311774
19TESK22.23987879
20NME12.20707147
21TNIK2.11491576
22PRKD32.04821680
23MAP3K42.02580447
24MAP3K122.00569065
25TAOK21.95091076
26WNK41.88581983
27DAPK21.81799468
28GRK51.76691356
29MARK11.74647123
30PNCK1.68441842
31BCR1.66431853
32CAMK2D1.66348121
33CDK191.65835905
34MAP2K71.65261387
35EPHA21.65147741
36MINK11.63750915
37CAMK2B1.63138903
38MAP3K91.61677577
39TAOK11.59228984
40EPHB21.55276847
41OBSCN1.48781962
42DDR21.44946412
43MAP2K41.44146019
44CAMK2G1.42716133
45GRK71.38886780
46PAK41.35600767
47FGFR41.33619106
48CAMK2A1.32687875
49PIM21.32361707
50NTRK11.32249672
51PKN11.27697663
52PRKG21.20962044
53PAK31.20826188
54PTK61.20766278
55CAMKK21.18950287
56PRPF4B1.17537560
57PAK61.17478905
58PLK21.16921204
59LMTK21.16710665
60NTRK21.16294250
61PDGFRA1.14768751
62MAPK151.13428910
63MARK21.12608497
64AKT31.12100483
65PTK21.10965634
66MAPKAPK51.09516885
67CDK51.08823505
68PINK11.07371796
69MYLK1.07109210
70EPHB11.06816599
71PRKCG1.05681511
72MAP3K101.04967695
73BRAF1.04948795
74MAP3K21.04714227
75ROCK21.01957262
76MAP3K11.01524317
77PKN20.99966276
78CDC42BPA0.99716552
79EEF2K0.99369389
80RPS6KA20.98289202
81PRKD20.97646320
82PRKCE0.96679606
83UHMK10.94749041
84ABL20.93918734
85KDR0.93751429
86BMPR20.92406094
87BMX0.89514774
88SGK2230.89261211
89SGK4940.89261211
90WNK10.86790701
91SIK20.86583210
92MAP4K10.86151902
93MST40.84561079
94KSR20.84543961
95MUSK0.84527841
96MAPK130.83261288
97PDK40.83062564
98PDK30.83062564
99FER0.82749412
100MAP3K30.81034321
101DYRK1B0.80708236
102MATK0.79197395
103WNK30.78364777
104TBK10.77608521
105LIMK10.75693129
106BCKDK0.75044756
107IRAK20.74329599
108LATS20.71606670
109FGR0.70872904
110MAP2K30.68561761
111CDK140.66724353
112TTN0.62726317
113DMPK0.61554420
114PRKACA0.61534183
115SCYL20.61080983
116CSNK1G30.60814207
117CAMK10.59605039
118MAP3K80.58976926
119SIK30.58866207
120DAPK10.58577267
121CDK180.56561900
122CDK120.55676906
123CDK150.54822236
124CSNK1G20.53585412
125STK110.52954838
126RIPK40.52424060
127PDPK10.52252295
128ADRBK20.51199124
129MAP3K130.50148823
130DAPK30.49986557
131IRAK10.49832659
132PDK20.49505883
133FES0.48711577
134RPS6KL10.48105829
135RPS6KC10.48105829
136MTOR0.47411807
137MST1R0.46821050
138MAP2K10.46088802
139PTK2B0.45950066
140ADRBK10.45944966
141CDK11A0.45315867
142MOS0.44548795
143ZAP700.44235565
144MAP2K20.43893293
145MET0.43683478
146MAPK120.42432260
147FGFR20.42038737
148KSR10.41674042
149NEK60.41205494
150TYRO30.40808785
151CAMK1D0.40224897
152CAMKK10.39837647
153LRRK20.39486454
154HIPK20.38088585
155PRKCA0.36969005
156CSNK1A1L0.36689256
157PRKG10.36627191
158MAPKAPK30.36156687
159SRC0.35750943
160GRK60.35413240
161CSK0.33549586
162FYN0.33512899
163MAP3K60.32559416
164MAP3K140.32024442

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.21621277
2Other glycan degradation_Homo sapiens_hsa005113.66807895
3Parkinsons disease_Homo sapiens_hsa050123.39187505
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.08167513
5Alzheimers disease_Homo sapiens_hsa050102.84316429
6Olfactory transduction_Homo sapiens_hsa047402.83951611
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.48864722
8Collecting duct acid secretion_Homo sapiens_hsa049662.48009389
9Synaptic vesicle cycle_Homo sapiens_hsa047212.47135249
10Cardiac muscle contraction_Homo sapiens_hsa042602.36932997
11Lysosome_Homo sapiens_hsa041422.28102200
12Nicotine addiction_Homo sapiens_hsa050332.21251626
13Huntingtons disease_Homo sapiens_hsa050162.14815870
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07142659
15Fatty acid elongation_Homo sapiens_hsa000622.03388624
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01327421
17Fructose and mannose metabolism_Homo sapiens_hsa000511.92604027
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89864651
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86387613
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86214513
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84526748
22GABAergic synapse_Homo sapiens_hsa047271.81954495
23Galactose metabolism_Homo sapiens_hsa000521.75875538
24Prion diseases_Homo sapiens_hsa050201.75323751
25Vibrio cholerae infection_Homo sapiens_hsa051101.71556106
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70379118
27Notch signaling pathway_Homo sapiens_hsa043301.63698067
28Morphine addiction_Homo sapiens_hsa050321.56405376
29Sulfur relay system_Homo sapiens_hsa041221.55699239
30Circadian entrainment_Homo sapiens_hsa047131.50350019
31Glutamatergic synapse_Homo sapiens_hsa047241.47803018
32VEGF signaling pathway_Homo sapiens_hsa043701.47375992
33Pentose phosphate pathway_Homo sapiens_hsa000301.47339907
34Propanoate metabolism_Homo sapiens_hsa006401.40725144
35Salmonella infection_Homo sapiens_hsa051321.40197160
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.39913463
37Taste transduction_Homo sapiens_hsa047421.38468882
38Bladder cancer_Homo sapiens_hsa052191.37099004
39Butanoate metabolism_Homo sapiens_hsa006501.36922978
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36070589
41Pyruvate metabolism_Homo sapiens_hsa006201.35244578
42Serotonergic synapse_Homo sapiens_hsa047261.33921024
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30777943
44Biosynthesis of amino acids_Homo sapiens_hsa012301.26686683
45Amphetamine addiction_Homo sapiens_hsa050311.24133802
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24114831
47Dopaminergic synapse_Homo sapiens_hsa047281.23986777
48Salivary secretion_Homo sapiens_hsa049701.23758730
49Sulfur metabolism_Homo sapiens_hsa009201.21895086
50Insulin secretion_Homo sapiens_hsa049111.20852648
51Endocytosis_Homo sapiens_hsa041441.20438955
52Long-term potentiation_Homo sapiens_hsa047201.17892049
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16560889
54Renin secretion_Homo sapiens_hsa049241.14378752
55Gastric acid secretion_Homo sapiens_hsa049711.11971483
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.11498338
57Chronic myeloid leukemia_Homo sapiens_hsa052201.10795995
58Shigellosis_Homo sapiens_hsa051311.09706646
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.08954158
60Calcium signaling pathway_Homo sapiens_hsa040201.08463475
61Cholinergic synapse_Homo sapiens_hsa047251.08213394
62Vitamin B6 metabolism_Homo sapiens_hsa007501.06959516
63Acute myeloid leukemia_Homo sapiens_hsa052211.06586849
64Renin-angiotensin system_Homo sapiens_hsa046141.04816627
65Leukocyte transendothelial migration_Homo sapiens_hsa046701.04566875
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01462023
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97672391
68Steroid biosynthesis_Homo sapiens_hsa001000.97341788
69Phototransduction_Homo sapiens_hsa047440.95700690
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94567095
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93389179
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.93185180
73Oxytocin signaling pathway_Homo sapiens_hsa049210.92838403
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91763621
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90703801
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90650108
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90014914
78ErbB signaling pathway_Homo sapiens_hsa040120.88489060
79Endometrial cancer_Homo sapiens_hsa052130.87860588
80Long-term depression_Homo sapiens_hsa047300.86532647
81Fatty acid metabolism_Homo sapiens_hsa012120.85518699
82Ether lipid metabolism_Homo sapiens_hsa005650.85377286
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85048640
84Osteoclast differentiation_Homo sapiens_hsa043800.83907942
85Dilated cardiomyopathy_Homo sapiens_hsa054140.81793912
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.81785769
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80398395
88Sphingolipid metabolism_Homo sapiens_hsa006000.80243257
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79496245
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78752730
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78649971
92Histidine metabolism_Homo sapiens_hsa003400.77935563
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77433743
94Hepatitis C_Homo sapiens_hsa051600.76256911
95Axon guidance_Homo sapiens_hsa043600.75679318
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74255484
97Glioma_Homo sapiens_hsa052140.73355898
98Cocaine addiction_Homo sapiens_hsa050300.72867221
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.71322312
100Insulin signaling pathway_Homo sapiens_hsa049100.70825541
101Pancreatic cancer_Homo sapiens_hsa052120.70623954
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70349249
103GnRH signaling pathway_Homo sapiens_hsa049120.70161196
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70117451
105Tuberculosis_Homo sapiens_hsa051520.69418004
106Proteasome_Homo sapiens_hsa030500.69151370
107Arginine biosynthesis_Homo sapiens_hsa002200.69088339
108Rap1 signaling pathway_Homo sapiens_hsa040150.68782644
109Mineral absorption_Homo sapiens_hsa049780.68516972
110Thyroid cancer_Homo sapiens_hsa052160.68111287
111Phenylalanine metabolism_Homo sapiens_hsa003600.66624541
112Amoebiasis_Homo sapiens_hsa051460.66481611
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66131263
114cAMP signaling pathway_Homo sapiens_hsa040240.65286160
115Apoptosis_Homo sapiens_hsa042100.64179098
116TNF signaling pathway_Homo sapiens_hsa046680.63995519
117Pertussis_Homo sapiens_hsa051330.63900613
118Protein export_Homo sapiens_hsa030600.63873582
119B cell receptor signaling pathway_Homo sapiens_hsa046620.61282641
120Renal cell carcinoma_Homo sapiens_hsa052110.61076102
121Non-small cell lung cancer_Homo sapiens_hsa052230.60699420
122Rheumatoid arthritis_Homo sapiens_hsa053230.60571262
123Carbon metabolism_Homo sapiens_hsa012000.60496586
124Fat digestion and absorption_Homo sapiens_hsa049750.60450538
125Peroxisome_Homo sapiens_hsa041460.59870285
126Fatty acid degradation_Homo sapiens_hsa000710.59251449
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58568447
128beta-Alanine metabolism_Homo sapiens_hsa004100.58384935
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56865800
130Arginine and proline metabolism_Homo sapiens_hsa003300.56641141
131Gap junction_Homo sapiens_hsa045400.56577584
132AMPK signaling pathway_Homo sapiens_hsa041520.56507695
133Regulation of autophagy_Homo sapiens_hsa041400.54551184
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54162225
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53553187
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53320097
137Glutathione metabolism_Homo sapiens_hsa004800.53216168
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52741672
139Tyrosine metabolism_Homo sapiens_hsa003500.52307526
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51813642
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50274232
142Chemokine signaling pathway_Homo sapiens_hsa040620.48359348
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47876405
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47751463
145Pancreatic secretion_Homo sapiens_hsa049720.47152885
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47034556
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.47034314
148* Metabolic pathways_Homo sapiens_hsa011000.46992287
149Choline metabolism in cancer_Homo sapiens_hsa052310.46722005
150Vitamin digestion and absorption_Homo sapiens_hsa049770.45861187
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45460353
152Melanogenesis_Homo sapiens_hsa049160.44955492
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44832831
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44009188
155Leishmaniasis_Homo sapiens_hsa051400.43815005
156Proteoglycans in cancer_Homo sapiens_hsa052050.43357385
157Adherens junction_Homo sapiens_hsa045200.42614067
158Focal adhesion_Homo sapiens_hsa045100.42532080
159Ovarian steroidogenesis_Homo sapiens_hsa049130.41667639
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.41594444
161Linoleic acid metabolism_Homo sapiens_hsa005910.41263045
162Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39573816
163Fatty acid biosynthesis_Homo sapiens_hsa000610.37021905
164Phagosome_Homo sapiens_hsa041450.36522514
165PPAR signaling pathway_Homo sapiens_hsa033200.35399717
166Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35142058
167Bile secretion_Homo sapiens_hsa049760.34506845
168Thyroid hormone synthesis_Homo sapiens_hsa049180.30285657
169Estrogen signaling pathway_Homo sapiens_hsa049150.30048385
170Tight junction_Homo sapiens_hsa045300.29943204
171alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28917033

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