FAM216A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.95988006
2ATP synthesis coupled proton transport (GO:0015986)4.57495622
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.57495622
4cilium or flagellum-dependent cell motility (GO:0001539)4.57113274
5ribosomal small subunit assembly (GO:0000028)4.55787825
6protein complex biogenesis (GO:0070271)4.37934721
7DNA deamination (GO:0045006)4.30520101
8mitochondrial respiratory chain complex assembly (GO:0033108)4.27606934
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23059789
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.23059789
11NADH dehydrogenase complex assembly (GO:0010257)4.23059789
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.22359440
13translational termination (GO:0006415)4.14826871
14viral transcription (GO:0019083)4.13595990
15maturation of SSU-rRNA (GO:0030490)4.00195714
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.94545697
17regulation of cilium movement (GO:0003352)3.80560876
18chromatin remodeling at centromere (GO:0031055)3.71660471
19epithelial cilium movement (GO:0003351)3.70861612
20ribosomal small subunit biogenesis (GO:0042274)3.70226651
21respiratory electron transport chain (GO:0022904)3.69088829
22electron transport chain (GO:0022900)3.63002170
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62747571
24cotranslational protein targeting to membrane (GO:0006613)3.59802465
25axonemal dynein complex assembly (GO:0070286)3.58489045
26translational elongation (GO:0006414)3.56125000
27CENP-A containing nucleosome assembly (GO:0034080)3.55318435
28protein targeting to ER (GO:0045047)3.53088495
29piRNA metabolic process (GO:0034587)3.53047849
30ribosomal large subunit biogenesis (GO:0042273)3.52761130
31protein localization to cilium (GO:0061512)3.48179990
32cilium movement (GO:0003341)3.45119598
33purine nucleobase biosynthetic process (GO:0009113)3.43977816
34intraciliary transport (GO:0042073)3.42291350
35pseudouridine synthesis (GO:0001522)3.42209929
36termination of RNA polymerase III transcription (GO:0006386)3.41406216
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.41406216
38histone arginine methylation (GO:0034969)3.41140431
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.40053964
40translational initiation (GO:0006413)3.38441049
41protein neddylation (GO:0045116)3.37488501
42synaptic vesicle exocytosis (GO:0016079)3.32637942
43protein localization to endoplasmic reticulum (GO:0070972)3.32333277
44nucleobase biosynthetic process (GO:0046112)3.29584443
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25766266
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24132827
47protein targeting to mitochondrion (GO:0006626)3.23779731
48rRNA modification (GO:0000154)3.23309129
49cellular protein complex disassembly (GO:0043624)3.23020099
50DNA replication checkpoint (GO:0000076)3.21474337
51translation (GO:0006412)3.19316178
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19156096
53telomere maintenance via semi-conservative replication (GO:0032201)3.18779542
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17876303
55cellular component biogenesis (GO:0044085)3.17536418
56cytochrome complex assembly (GO:0017004)3.16573962
57maturation of 5.8S rRNA (GO:0000460)3.16508526
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16467866
59binding of sperm to zona pellucida (GO:0007339)3.13477838
60respiratory chain complex IV assembly (GO:0008535)3.13180122
61establishment of protein localization to mitochondrion (GO:0072655)3.11297421
62viral life cycle (GO:0019058)3.07586399
63DNA damage response, detection of DNA damage (GO:0042769)3.07377068
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07197253
65somatic hypermutation of immunoglobulin genes (GO:0016446)3.07197253
66sperm-egg recognition (GO:0035036)3.06409636
67DNA double-strand break processing (GO:0000729)3.05154552
68peptidyl-arginine omega-N-methylation (GO:0035247)3.04541196
69rRNA processing (GO:0006364)3.02393071
70fusion of sperm to egg plasma membrane (GO:0007342)3.01815971
71protein localization to mitochondrion (GO:0070585)3.00903778
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99481644
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99481644
74sperm motility (GO:0030317)2.98959553
75DNA strand elongation involved in DNA replication (GO:0006271)2.98725315
76deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.97094907
77rRNA metabolic process (GO:0016072)2.94271109
78ribonucleoprotein complex biogenesis (GO:0022613)2.93958607
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93474130
80oxidative phosphorylation (GO:0006119)2.89125517
81microtubule severing (GO:0051013)2.88535555
82protein complex disassembly (GO:0043241)2.88281754
83guanosine-containing compound biosynthetic process (GO:1901070)2.88098255
84negative regulation of microtubule polymerization (GO:0031115)2.87020372
85protein polyglutamylation (GO:0018095)2.85453908
86DNA strand elongation (GO:0022616)2.84862406
87histone H2A acetylation (GO:0043968)2.84515546
88GTP biosynthetic process (GO:0006183)2.84280648
89regulation of microtubule-based movement (GO:0060632)2.84193967
90protein localization to synapse (GO:0035418)2.83610310
91positive regulation of synapse maturation (GO:0090129)2.83552316
92macromolecular complex disassembly (GO:0032984)2.80871545
93purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80683838
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.80406100
95metallo-sulfur cluster assembly (GO:0031163)2.80098689
96iron-sulfur cluster assembly (GO:0016226)2.80098689
97regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80060092
98purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79199363
99spermatid development (GO:0007286)2.78648822
100behavioral response to nicotine (GO:0035095)2.78638388
101intracellular protein transmembrane import (GO:0044743)2.74382299
102telomere maintenance via recombination (GO:0000722)2.73947910
103tRNA processing (GO:0008033)2.73347889
104male meiosis (GO:0007140)2.73280724
105DNA catabolic process, exonucleolytic (GO:0000738)2.71431210
106synaptic vesicle maturation (GO:0016188)2.68844792
107kinetochore organization (GO:0051383)2.67427139
108IMP biosynthetic process (GO:0006188)2.67293670
109peptidyl-histidine modification (GO:0018202)2.66545836
110acrosome assembly (GO:0001675)2.66321122
111acrosome reaction (GO:0007340)2.66126111
112establishment of integrated proviral latency (GO:0075713)2.65828679
113CTP biosynthetic process (GO:0006241)2.65045889
114CTP metabolic process (GO:0046036)2.65045889
115motile cilium assembly (GO:0044458)2.64100766
116peptidyl-arginine methylation (GO:0018216)2.60693094
117peptidyl-arginine N-methylation (GO:0035246)2.60693094
118UTP biosynthetic process (GO:0006228)2.60566561
119cullin deneddylation (GO:0010388)2.58470920
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56526002
121response to pheromone (GO:0019236)2.54726784
122cell-cell recognition (GO:0009988)2.53125849
123synaptonemal complex organization (GO:0070193)2.51815973
124ventricular system development (GO:0021591)2.51358283
125DNA methylation involved in gamete generation (GO:0043046)2.51070571
126protein maturation by protein folding (GO:0022417)2.50902038
127regulation of synaptic vesicle exocytosis (GO:2000300)2.50658599
128axoneme assembly (GO:0035082)2.50588345
129pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.49318176
130pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.48937875
131spliceosomal snRNP assembly (GO:0000387)2.47715687
132plasma membrane fusion (GO:0045026)2.46497453
133pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.44360185
134protein deneddylation (GO:0000338)2.41822508
135cilium morphogenesis (GO:0060271)2.41209362
136de novo posttranslational protein folding (GO:0051084)2.38426180
137regulation of mitochondrial translation (GO:0070129)2.38088702
138de novo protein folding (GO:0006458)2.38055583
139neuron cell-cell adhesion (GO:0007158)2.37389207
140protein insertion into membrane (GO:0051205)2.35855276
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.34296607
142COPI coating of Golgi vesicle (GO:0048205)2.33379338
143Golgi transport vesicle coating (GO:0048200)2.33379338
144GMP metabolic process (GO:0046037)2.32718391
145intra-S DNA damage checkpoint (GO:0031573)2.29892456
146postsynaptic membrane organization (GO:0001941)2.29341471
147synaptonemal complex assembly (GO:0007130)2.26947936
148vocalization behavior (GO:0071625)2.26409472
149regulation of synaptic vesicle transport (GO:1902803)2.24098371
150glutamate secretion (GO:0014047)2.23403780
151male meiosis I (GO:0007141)2.23297122
152pyrimidine nucleotide catabolic process (GO:0006244)2.23068508
153synaptic vesicle docking involved in exocytosis (GO:0016081)2.22343000
154calcium ion-dependent exocytosis (GO:0017156)2.19313472
155UTP metabolic process (GO:0046051)2.18290436
156pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.17957574
1577-methylguanosine RNA capping (GO:0009452)2.17815928
158RNA capping (GO:0036260)2.17815928
1597-methylguanosine mRNA capping (GO:0006370)2.17761922
160nucleosome disassembly (GO:0006337)2.16756265
161protein-DNA complex disassembly (GO:0032986)2.16756265
162microtubule-based transport (GO:0010970)2.16398806
163proteasome assembly (GO:0043248)2.15009983
164microtubule-based movement (GO:0007018)2.13781107
165inner mitochondrial membrane organization (GO:0007007)2.13113178
166mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.12704984
167oxidative demethylation (GO:0070989)2.12167594
168negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.11835523
169histone exchange (GO:0043486)2.11375166
170spliceosomal complex assembly (GO:0000245)2.09978644
171pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.08421234
172meiosis I (GO:0007127)2.08397342
173meiotic nuclear division (GO:0007126)2.07882297
174regulation of neuronal synaptic plasticity (GO:0048168)2.06484728
175chaperone-mediated protein transport (GO:0072321)2.06312847
176cilium organization (GO:0044782)2.05665657
177left/right pattern formation (GO:0060972)2.04992560
178cilium assembly (GO:0042384)2.04971895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08346230
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.13638225
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.64478311
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19673625
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97055441
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63912194
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.58681270
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49429635
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47997212
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35836600
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32805447
12ELK1_19687146_ChIP-ChIP_HELA_Human2.27436333
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.19623938
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.17562835
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12035200
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07456849
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99106452
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97807250
19THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97594347
20FUS_26573619_Chip-Seq_HEK293_Human1.91500803
21EWS_26573619_Chip-Seq_HEK293_Human1.88808424
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88210974
23XRN2_22483619_ChIP-Seq_HELA_Human1.84856134
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.82350238
25REST_21632747_ChIP-Seq_MESCs_Mouse1.81063816
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78011197
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76620003
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.72955625
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69264261
30VDR_22108803_ChIP-Seq_LS180_Human1.69104580
31SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.64320982
32GABP_19822575_ChIP-Seq_HepG2_Human1.63945836
33ZNF274_21170338_ChIP-Seq_K562_Hela1.63923906
34SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.62689845
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61023231
36IGF1R_20145208_ChIP-Seq_DFB_Human1.55771432
37VDR_23849224_ChIP-Seq_CD4+_Human1.52242335
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48710364
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.47111533
40CIITA_25753668_ChIP-Seq_RAJI_Human1.46448079
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43592184
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42948809
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42882082
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41810847
45TTF2_22483619_ChIP-Seq_HELA_Human1.41459555
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40253413
47FOXP3_21729870_ChIP-Seq_TREG_Human1.40245230
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38726450
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36768059
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36554153
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36144437
52KDM5A_27292631_Chip-Seq_BREAST_Human1.35551006
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33439235
54CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32296634
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.31940726
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31262761
57DCP1A_22483619_ChIP-Seq_HELA_Human1.29760754
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29706864
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28139295
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26346752
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25822053
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.25092671
63IRF1_19129219_ChIP-ChIP_H3396_Human1.24467605
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22687251
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21904961
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20710582
67TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.20481092
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19714257
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.19158135
70TP53_22573176_ChIP-Seq_HFKS_Human1.18152102
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16966547
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16725058
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15880009
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.15644168
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15035710
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.13985143
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13588058
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13422107
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13234097
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12763744
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.12563614
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.12243402
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12234710
84E2F7_22180533_ChIP-Seq_HELA_Human1.11822701
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11691247
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.10944059
87GBX2_23144817_ChIP-Seq_PC3_Human1.09474321
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.08692913
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.08377335
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07877060
91TAF15_26573619_Chip-Seq_HEK293_Human1.07849679
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07376260
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06562725
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05681966
95JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05014276
96RNF2_27304074_Chip-Seq_NSC_Mouse1.04795277
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02138631
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02103600
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01395334
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01307890
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01255634
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01202797
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00910925
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00881193
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98202798
106JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97865211
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.96462475
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94530234
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94197904
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93597676
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92858103
112FOXP1_21924763_ChIP-Seq_HESCs_Human0.92754790
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92401214
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92393153
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92231781
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91717493
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91712598
118FLI1_27457419_Chip-Seq_LIVER_Mouse0.91234681
119REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90440859
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89810361
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88632692
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88082129
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86583441
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85289284
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84648399
126P300_19829295_ChIP-Seq_ESCs_Human0.84521635
127MYC_18940864_ChIP-ChIP_HL60_Human0.82973248
128RNF2_27304074_Chip-Seq_ESCs_Mouse0.82039294
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81683678
130HTT_18923047_ChIP-ChIP_STHdh_Human0.80963358
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80310944
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.80095341
133E2F1_21310950_ChIP-Seq_MCF-7_Human0.79886840
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.78991642
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78831258
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77568588
137PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77260763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.44241990
2MP0004859_abnormal_synaptic_plasticity3.39509489
3MP0005410_abnormal_fertilization3.00301048
4MP0005423_abnormal_somatic_nervous2.88886874
5MP0003635_abnormal_synaptic_transmissio2.50427051
6MP0004270_analgesia2.34533480
7MP0009379_abnormal_foot_pigmentation2.34382959
8MP0001984_abnormal_olfaction2.30500252
9MP0003122_maternal_imprinting2.24298512
10MP0009697_abnormal_copulation2.09309051
11MP0008877_abnormal_DNA_methylation2.07684964
12MP0001188_hyperpigmentation2.02444313
13MP0002063_abnormal_learning/memory/cond2.00437427
14MP0006292_abnormal_olfactory_placode1.95131841
15MP0006276_abnormal_autonomic_nervous1.84771261
16MP0004147_increased_porphyrin_level1.84476802
17MP0003718_maternal_effect1.84080794
18MP0009745_abnormal_behavioral_response1.81108441
19MP0003698_abnormal_male_reproductive1.79702203
20MP0002572_abnormal_emotion/affect_behav1.75383753
21MP0001529_abnormal_vocalization1.75340431
22MP0006036_abnormal_mitochondrial_physio1.75250165
23MP0006035_abnormal_mitochondrial_morpho1.74169927
24MP0001929_abnormal_gametogenesis1.71965393
25MP0002734_abnormal_mechanical_nocicepti1.69487484
26MP0001968_abnormal_touch/_nociception1.64426919
27MP0002653_abnormal_ependyma_morphology1.64109020
28MP0002184_abnormal_innervation1.63199550
29MP0000631_abnormal_neuroendocrine_gland1.62936395
30MP0000372_irregular_coat_pigmentation1.59348002
31MP0003283_abnormal_digestive_organ1.58903602
32MP0002272_abnormal_nervous_system1.55630521
33MP0002160_abnormal_reproductive_system1.53785894
34MP0002822_catalepsy1.53165943
35MP0002102_abnormal_ear_morphology1.52157675
36MP0003123_paternal_imprinting1.50747003
37MP0002064_seizures1.49449540
38MP0004811_abnormal_neuron_physiology1.49283682
39MP0002557_abnormal_social/conspecific_i1.49194831
40MP0002638_abnormal_pupillary_reflex1.47843266
41MP0003786_premature_aging1.47715429
42MP0003121_genomic_imprinting1.46776278
43MP0008058_abnormal_DNA_repair1.46110205
44MP0002234_abnormal_pharynx_morphology1.44573496
45MP0002751_abnormal_autonomic_nervous1.43140847
46MP0008007_abnormal_cellular_replicative1.42443597
47MP0000778_abnormal_nervous_system1.42345623
48MP0004133_heterotaxia1.40351224
49MP0005645_abnormal_hypothalamus_physiol1.39545343
50MP0003186_abnormal_redox_activity1.39432280
51MP0009046_muscle_twitch1.38964140
52MP0005084_abnormal_gallbladder_morpholo1.38703994
53MP0003806_abnormal_nucleotide_metabolis1.37520034
54MP0002210_abnormal_sex_determination1.36355577
55MP0008057_abnormal_DNA_replication1.36332657
56MP0009780_abnormal_chondrocyte_physiolo1.35693928
57MP0006072_abnormal_retinal_apoptosis1.35372893
58MP0002909_abnormal_adrenal_gland1.33764303
59MP0002837_dystrophic_cardiac_calcinosis1.32984655
60MP0002163_abnormal_gland_morphology1.28879997
61MP0002733_abnormal_thermal_nociception1.28441956
62MP0000955_abnormal_spinal_cord1.27876769
63MP0001486_abnormal_startle_reflex1.24280215
64MP0010094_abnormal_chromosome_stability1.23834986
65MP0002067_abnormal_sensory_capabilities1.22471846
66MP0001145_abnormal_male_reproductive1.21683903
67MP0001986_abnormal_taste_sensitivity1.21333054
68MP0005646_abnormal_pituitary_gland1.21099215
69MP0001502_abnormal_circadian_rhythm1.20563730
70MP0005394_taste/olfaction_phenotype1.19882765
71MP0005499_abnormal_olfactory_system1.19882765
72MP0001970_abnormal_pain_threshold1.19515014
73MP0000013_abnormal_adipose_tissue1.19309099
74MP0002882_abnormal_neuron_morphology1.17633602
75MP0002736_abnormal_nociception_after1.17419191
76MP0001905_abnormal_dopamine_level1.17114305
77MP0004142_abnormal_muscle_tone1.16348656
78MP0004233_abnormal_muscle_weight1.15955183
79MP0008789_abnormal_olfactory_epithelium1.15738553
80MP0002938_white_spotting1.14886588
81MP0002152_abnormal_brain_morphology1.14782979
82MP0003136_yellow_coat_color1.14643594
83MP0008569_lethality_at_weaning1.11562930
84MP0008872_abnormal_physiological_respon1.10640314
85MP0005174_abnormal_tail_pigmentation1.10417391
86MP0003861_abnormal_nervous_system1.09421309
87MP0003879_abnormal_hair_cell1.09173843
88MP0002161_abnormal_fertility/fecundity1.05936875
89MP0002735_abnormal_chemical_nociception1.05409225
90MP0000653_abnormal_sex_gland1.04139021
91MP0001764_abnormal_homeostasis1.01250134
92MP0000015_abnormal_ear_pigmentation0.99752502
93MP0003787_abnormal_imprinting0.99584335
94MP0004957_abnormal_blastocyst_morpholog0.99183980
95MP0003077_abnormal_cell_cycle0.98815661
96MP0008932_abnormal_embryonic_tissue0.98549315
97MP0003111_abnormal_nucleus_morphology0.97607178
98MP0003567_abnormal_fetal_cardiomyocyte0.97250872
99MP0005253_abnormal_eye_physiology0.97002542
100MP0001440_abnormal_grooming_behavior0.96835034
101MP0003315_abnormal_perineum_morphology0.96427169
102MP0005389_reproductive_system_phenotype0.95127359
103MP0005551_abnormal_eye_electrophysiolog0.94883519
104MP0001944_abnormal_pancreas_morphology0.94037203
105MP0010030_abnormal_orbit_morphology0.93917805
106MP0003693_abnormal_embryo_hatching0.92493191
107MP0002752_abnormal_somatic_nervous0.89019855
108MP0008961_abnormal_basal_metabolism0.87631174
109MP0004924_abnormal_behavior0.85762297
110MP0005386_behavior/neurological_phenoty0.85762297
111MP0000358_abnormal_cell_content/0.84359422
112MP0000049_abnormal_middle_ear0.83698198
113MP0002066_abnormal_motor_capabilities/c0.82993243
114MP0002396_abnormal_hematopoietic_system0.81448325
115MP0003329_amyloid_beta_deposits0.80271465
116MP0003937_abnormal_limbs/digits/tail_de0.80171314
117MP0000678_abnormal_parathyroid_gland0.78146772
118MP0003119_abnormal_digestive_system0.77194158
119MP0004145_abnormal_muscle_electrophysio0.76706825
120MP0008995_early_reproductive_senescence0.76372289
121MP0001919_abnormal_reproductive_system0.75695400
122MP0005187_abnormal_penis_morphology0.75418625
123MP0002095_abnormal_skin_pigmentation0.74433634
124MP0001293_anophthalmia0.73141222
125MP0001485_abnormal_pinna_reflex0.72561304
126MP0004215_abnormal_myocardial_fiber0.72039583
127MP0005195_abnormal_posterior_eye0.71893533
128MP0006054_spinal_hemorrhage0.70539415

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.47039921
2Abnormal mitochondria in muscle tissue (HP:0008316)4.17524428
3Absent/shortened dynein arms (HP:0200106)4.11164154
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.11164154
5Mitochondrial inheritance (HP:0001427)4.08849022
6Acute encephalopathy (HP:0006846)4.02164325
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.00592972
8Abnormal respiratory epithelium morphology (HP:0012253)3.99898043
9Abnormal respiratory motile cilium morphology (HP:0005938)3.99898043
10Increased hepatocellular lipid droplets (HP:0006565)3.97764066
11Lipid accumulation in hepatocytes (HP:0006561)3.82466740
12Increased CSF lactate (HP:0002490)3.81147736
13Progressive macrocephaly (HP:0004481)3.76591522
14Abnormal respiratory motile cilium physiology (HP:0012261)3.69121539
15Hepatocellular necrosis (HP:0001404)3.58130149
16Reticulocytopenia (HP:0001896)3.40290708
17Hepatic necrosis (HP:0002605)3.38917355
18Abnormal ciliary motility (HP:0012262)3.34972878
19Rhinitis (HP:0012384)3.34493875
20Cerebral edema (HP:0002181)3.25347625
21Renal Fanconi syndrome (HP:0001994)3.22158820
22Increased intramyocellular lipid droplets (HP:0012240)3.21143002
23Nephrogenic diabetes insipidus (HP:0009806)3.18695312
24Medial flaring of the eyebrow (HP:0010747)3.13375957
25Progressive cerebellar ataxia (HP:0002073)3.06219497
26Retinal dysplasia (HP:0007973)3.02290952
27Severe visual impairment (HP:0001141)2.99086269
28Gait imbalance (HP:0002141)2.97606621
29Increased serum lactate (HP:0002151)2.89260470
303-Methylglutaconic aciduria (HP:0003535)2.84760910
31Congenital primary aphakia (HP:0007707)2.81384601
32Visual hallucinations (HP:0002367)2.80987071
33Lissencephaly (HP:0001339)2.79598496
34Molar tooth sign on MRI (HP:0002419)2.77371929
35Abnormality of midbrain morphology (HP:0002418)2.77371929
36Lactic acidosis (HP:0003128)2.75964805
37Aplastic anemia (HP:0001915)2.75084000
38Increased muscle lipid content (HP:0009058)2.73250553
3911 pairs of ribs (HP:0000878)2.71533456
40Chronic bronchitis (HP:0004469)2.69597857
41Macrocytic anemia (HP:0001972)2.65403332
42True hermaphroditism (HP:0010459)2.64072626
43Nephronophthisis (HP:0000090)2.60565211
44Central scotoma (HP:0000603)2.59781231
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57375880
46Myokymia (HP:0002411)2.53375283
47Pancreatic fibrosis (HP:0100732)2.53229868
48Focal motor seizures (HP:0011153)2.52846374
49Pancreatic cysts (HP:0001737)2.48844404
50Cerebral hypomyelination (HP:0006808)2.43866658
51Optic disc pallor (HP:0000543)2.41200015
52Amyotrophic lateral sclerosis (HP:0007354)2.38968230
53Hyperglycinemia (HP:0002154)2.33254787
54Exercise intolerance (HP:0003546)2.31534490
55Type II lissencephaly (HP:0007260)2.30286943
56Meckel diverticulum (HP:0002245)2.28144583
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.26828439
58Epileptic encephalopathy (HP:0200134)2.26750833
59Exertional dyspnea (HP:0002875)2.24896002
60Absent thumb (HP:0009777)2.24505576
61Abnormality of the ileum (HP:0001549)2.23803569
62Infertility (HP:0000789)2.22988327
63Colon cancer (HP:0003003)2.22772884
64Methylmalonic acidemia (HP:0002912)2.20516979
65Menstrual irregularities (HP:0000858)2.20459194
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18979461
67Microvesicular hepatic steatosis (HP:0001414)2.15687149
68Aplasia/Hypoplasia of the lens (HP:0008063)2.15449212
69Pallor (HP:0000980)2.14943310
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14904093
71Respiratory failure (HP:0002878)2.14208387
72Lethargy (HP:0001254)2.13999273
73Respiratory difficulties (HP:0002880)2.13617030
74Type I transferrin isoform profile (HP:0003642)2.12604301
75Neuroendocrine neoplasm (HP:0100634)2.10329754
76Chromsome breakage (HP:0040012)2.08461476
77Leukodystrophy (HP:0002415)2.08409744
78Abnormal number of erythroid precursors (HP:0012131)2.07373961
79Large eyes (HP:0001090)2.03459065
80Facial cleft (HP:0002006)2.02991884
81Abnormality of cells of the erythroid lineage (HP:0012130)2.01634232
82Sclerocornea (HP:0000647)2.01385007
83Vaginal atresia (HP:0000148)2.01219338
84Triphalangeal thumb (HP:0001199)2.00233143
85Bifid tongue (HP:0010297)1.99913157
86Limb dystonia (HP:0002451)1.99698042
87Congenital stationary night blindness (HP:0007642)1.99101171
88Abnormality of renal resorption (HP:0011038)1.98297812
89Abnormal protein glycosylation (HP:0012346)1.97317560
90Abnormal glycosylation (HP:0012345)1.97317560
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97317560
92Abnormal protein N-linked glycosylation (HP:0012347)1.97317560
93Genital tract atresia (HP:0001827)1.96067704
94Pheochromocytoma (HP:0002666)1.94499405
95Methylmalonic aciduria (HP:0012120)1.93162756
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.91944169
97Renal cortical cysts (HP:0000803)1.91411673
98Pancytopenia (HP:0001876)1.89614831
99Progressive microcephaly (HP:0000253)1.88940964
100Abnormality of the preputium (HP:0100587)1.87780642
101Microretrognathia (HP:0000308)1.86543764
102Abnormality of the lower motor neuron (HP:0002366)1.85380086
103Abnormality of chromosome stability (HP:0003220)1.85149862
104CNS hypomyelination (HP:0003429)1.84625793
105Abnormality of the renal collecting system (HP:0004742)1.82565259
106Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81939804
107Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81939804
108Febrile seizures (HP:0002373)1.81370445
109Gonadotropin excess (HP:0000837)1.81360079
110Abnormal rod and cone electroretinograms (HP:0008323)1.81189047
111Postaxial hand polydactyly (HP:0001162)1.81154350
112Cerebellar dysplasia (HP:0007033)1.81102521
113Poor suck (HP:0002033)1.81056637
114Agitation (HP:0000713)1.78550634
115Depression (HP:0000716)1.78312198
116Insomnia (HP:0100785)1.77390302
117Glycosuria (HP:0003076)1.75877985
118Abnormality of urine glucose concentration (HP:0011016)1.75877985
119Median cleft lip (HP:0000161)1.75765553
120Abnormality of the labia minora (HP:0012880)1.75584064
121Specific learning disability (HP:0001328)1.75071071
122Atrophy/Degeneration involving motor neurons (HP:0007373)1.74961274
123Ankle clonus (HP:0011448)1.74625172
124Pendular nystagmus (HP:0012043)1.74125981
125Postaxial foot polydactyly (HP:0001830)1.73384633
126Truncal ataxia (HP:0002078)1.73359964
127Hyperglycinuria (HP:0003108)1.71195781
128Atonic seizures (HP:0010819)1.71179377
129Degeneration of anterior horn cells (HP:0002398)1.70022778
130Abnormality of the anterior horn cell (HP:0006802)1.70022778
131Abnormality of macular pigmentation (HP:0008002)1.69644110
132Sloping forehead (HP:0000340)1.69104825
133Abnormality of alanine metabolism (HP:0010916)1.68814346
134Hyperalaninemia (HP:0003348)1.68814346
135Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68814346
136Abnormality of serum amino acid levels (HP:0003112)1.68801562
137Supernumerary spleens (HP:0009799)1.68012601
138Broad foot (HP:0001769)1.67750389
139Duodenal stenosis (HP:0100867)1.67602207
140Small intestinal stenosis (HP:0012848)1.67602207
141Shoulder girdle muscle weakness (HP:0003547)1.67571095
142CNS demyelination (HP:0007305)1.67461120
143Myelodysplasia (HP:0002863)1.66220468
144Generalized aminoaciduria (HP:0002909)1.65303416
145Emotional lability (HP:0000712)1.64972506
146Missing ribs (HP:0000921)1.64960525
147Hypoplasia of the pons (HP:0012110)1.64516013
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64297417
149Focal seizures (HP:0007359)1.63697997
150Spinal canal stenosis (HP:0003416)1.63360448
151Poor coordination (HP:0002370)1.63255461
152Dicarboxylic aciduria (HP:0003215)1.63182037
153Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63182037
154Bronchiectasis (HP:0002110)1.63018059
155Abnormality of dentin (HP:0010299)1.62923892
156Constricted visual fields (HP:0001133)1.62253061
157Preaxial hand polydactyly (HP:0001177)1.61470854
158Abnormality of the renal medulla (HP:0100957)1.60940802
159Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60589808
160Hypoplasia of the brainstem (HP:0002365)1.60589808
161Unsteady gait (HP:0002317)1.59584286
162Megalocornea (HP:0000485)1.58803855
163Cystic liver disease (HP:0006706)1.57471349
164Neoplasm of the peripheral nervous system (HP:0100007)1.57364610
165Aganglionic megacolon (HP:0002251)1.56616277
166Dyschromatopsia (HP:0007641)1.54435204
167Selective tooth agenesis (HP:0001592)1.54078817
168Anencephaly (HP:0002323)1.52277826
169Oculomotor apraxia (HP:0000657)1.52259554
170Decreased testicular size (HP:0008734)1.50702351
171Amblyopia (HP:0000646)1.50299856
172Delusions (HP:0000746)1.49596615
173Anxiety (HP:0000739)1.48485683
174Scotoma (HP:0000575)1.47506118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.51615323
2VRK23.19537305
3ZAK3.17168087
4BUB13.08329766
5STK162.87164930
6PRKD32.50553918
7TNIK2.44029878
8TESK12.42620340
9MAP4K22.37600485
10ARAF2.36836636
11NTRK32.35984330
12MINK12.14566390
13DYRK32.09015344
14MUSK2.02931319
15PDK41.86619888
16PDK31.86619888
17MARK11.85180949
18WEE11.83207021
19BRSK11.78299061
20NUAK11.77138820
21UHMK11.74245480
22CDK191.73173530
23SRPK11.72167416
24CDC71.71720234
25PASK1.68671547
26DAPK11.68580907
27MAPK131.66469213
28CCNB11.60031968
29MAP3K121.58185022
30MAP2K71.56288490
31VRK11.56088037
32NME21.55356186
33MAP3K91.51623658
34BRAF1.51235888
35KSR11.47481272
36PBK1.46214970
37NTRK21.40404330
38MAPKAPK31.40185834
39SCYL21.39938152
40EPHA41.39645570
41WNK31.37910540
42TESK21.37570181
43PINK11.36404189
44CDK81.35876684
45CAMKK21.34760920
46BRSK21.33041749
47MAP3K41.32143504
48TLK11.29931422
49TTK1.25776399
50SIK31.23867464
51NEK21.21094003
52FRK1.20543879
53ADRBK21.18494121
54DYRK21.16026462
55WNK41.13315974
56TAF11.11958120
57RAF11.11620808
58MAPK151.06104892
59NME11.04167453
60MAP3K110.99472254
61AURKA0.99270917
62PNCK0.98649298
63TAOK30.97105652
64GRK10.96861855
65PAK60.95187568
66RPS6KA50.95167566
67LIMK10.91533667
68PIM20.91086021
69CDK140.89677930
70PLK20.88073891
71PLK30.86086344
72CDK180.85693130
73CSNK1G10.85431581
74CAMKK10.85101581
75INSRR0.84676649
76ERBB30.83760479
77NEK10.81410558
78PLK10.79763985
79CDK150.77992704
80CDK50.77869774
81CDK11A0.75442963
82PRKCG0.75012801
83CSNK1A1L0.74336004
84DYRK1A0.73429470
85ATR0.73081719
86TSSK60.72410994
87HIPK20.72024887
88MKNK10.71722554
89DYRK1B0.71503242
90ATM0.71465802
91OXSR10.70652348
92TGFBR10.70427809
93TRIM280.70399582
94ACVR1B0.67959848
95EIF2AK20.67864792
96CHEK20.67728594
97CSNK2A20.65678520
98PTK2B0.65610590
99EIF2AK30.65332056
100EEF2K0.64164075
101BMPR1B0.62150184
102SIK20.60935752
103KSR20.59620317
104STK390.57415641
105CAMK2B0.57045234
106RPS6KA40.56803933
107TEC0.56185430
108KDR0.56124372
109CSNK2A10.54133379
110MAPKAPK50.53474951
111CSNK1G20.52955898
112MKNK20.52378672
113PLK40.50816193
114GRK50.48590877
115CDK30.48539995
116ICK0.45993095
117KIT0.43336118
118CDK20.42822164
119NTRK10.41871167
120STK40.41756054
121CSNK1E0.41684462
122MAP3K60.40408510
123PAK10.39978884
124PDK20.39748429
125MST40.39410952
126TXK0.37857900
127CHEK10.37662899
128BCR0.37217354
129CSNK1G30.37194166
130CSNK1A10.36580238
131CDK10.36256661
132ADRBK10.35570874
133TYRO30.35453602
134DAPK20.35346628
135CAMK2A0.35316967
136PAK30.34645088
137AURKB0.34103885
138CASK0.33954622
139EIF2AK10.32212768
140CAMK10.32006341
141MAP2K40.31129537
142FLT30.30952822

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.35856497
2Nicotine addiction_Homo sapiens_hsa050332.24071874
3DNA replication_Homo sapiens_hsa030302.22090609
4Synaptic vesicle cycle_Homo sapiens_hsa047212.06383472
5Spliceosome_Homo sapiens_hsa030401.96439629
6Olfactory transduction_Homo sapiens_hsa047401.94217416
7Proteasome_Homo sapiens_hsa030501.89637970
8Protein export_Homo sapiens_hsa030601.89613162
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87856100
10Circadian entrainment_Homo sapiens_hsa047131.87565600
11Amphetamine addiction_Homo sapiens_hsa050311.87399508
12Ribosome_Homo sapiens_hsa030101.83847066
13Dopaminergic synapse_Homo sapiens_hsa047281.77323275
14Mismatch repair_Homo sapiens_hsa034301.76902559
15RNA polymerase_Homo sapiens_hsa030201.75488006
16Long-term potentiation_Homo sapiens_hsa047201.74174191
17Oocyte meiosis_Homo sapiens_hsa041141.72573568
18GABAergic synapse_Homo sapiens_hsa047271.71312302
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65613486
20Base excision repair_Homo sapiens_hsa034101.64530716
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62176386
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61250678
23RNA transport_Homo sapiens_hsa030131.60521375
24Sulfur relay system_Homo sapiens_hsa041221.57833729
25Insulin secretion_Homo sapiens_hsa049111.57751597
26Morphine addiction_Homo sapiens_hsa050321.56263375
27Alcoholism_Homo sapiens_hsa050341.55056523
28Basal transcription factors_Homo sapiens_hsa030221.52421820
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50417195
30Propanoate metabolism_Homo sapiens_hsa006401.48891614
31Huntingtons disease_Homo sapiens_hsa050161.45438363
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45141176
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42382512
34Nucleotide excision repair_Homo sapiens_hsa034201.41363920
35Pyrimidine metabolism_Homo sapiens_hsa002401.40479241
36Cell cycle_Homo sapiens_hsa041101.40003713
37Glutamatergic synapse_Homo sapiens_hsa047241.39732996
38Parkinsons disease_Homo sapiens_hsa050121.37244994
39mRNA surveillance pathway_Homo sapiens_hsa030151.33720437
40Taste transduction_Homo sapiens_hsa047421.31963076
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28102585
42Selenocompound metabolism_Homo sapiens_hsa004501.26236497
43N-Glycan biosynthesis_Homo sapiens_hsa005101.25468923
44Cocaine addiction_Homo sapiens_hsa050301.25188703
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25017472
46RNA degradation_Homo sapiens_hsa030181.23018119
47Serotonergic synapse_Homo sapiens_hsa047261.22907533
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.20472297
49Oxidative phosphorylation_Homo sapiens_hsa001901.17115388
50Purine metabolism_Homo sapiens_hsa002301.15633107
51Fanconi anemia pathway_Homo sapiens_hsa034601.15368854
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12850304
53Cholinergic synapse_Homo sapiens_hsa047251.12710784
54Vibrio cholerae infection_Homo sapiens_hsa051101.12236024
55Pyruvate metabolism_Homo sapiens_hsa006201.11668913
56Folate biosynthesis_Homo sapiens_hsa007901.09987664
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07554118
58Butanoate metabolism_Homo sapiens_hsa006501.06942357
59Cardiac muscle contraction_Homo sapiens_hsa042601.04946083
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02640001
61Alzheimers disease_Homo sapiens_hsa050101.02252902
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01102485
63Phototransduction_Homo sapiens_hsa047440.99013856
64Homologous recombination_Homo sapiens_hsa034400.96882429
65Non-homologous end-joining_Homo sapiens_hsa034500.94086613
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93547419
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92283019
68Gap junction_Homo sapiens_hsa045400.91844972
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90998537
70Long-term depression_Homo sapiens_hsa047300.90837436
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.90573637
72Oxytocin signaling pathway_Homo sapiens_hsa049210.87798196
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85941354
74Nitrogen metabolism_Homo sapiens_hsa009100.85499072
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84884501
76Renin secretion_Homo sapiens_hsa049240.84665758
77Metabolic pathways_Homo sapiens_hsa011000.81962073
78Peroxisome_Homo sapiens_hsa041460.81743421
79Fatty acid elongation_Homo sapiens_hsa000620.81280618
80Glucagon signaling pathway_Homo sapiens_hsa049220.81107288
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80737472
82Melanogenesis_Homo sapiens_hsa049160.77709589
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74448057
84Salivary secretion_Homo sapiens_hsa049700.73289944
85Calcium signaling pathway_Homo sapiens_hsa040200.72407367
86Collecting duct acid secretion_Homo sapiens_hsa049660.72161373
87Circadian rhythm_Homo sapiens_hsa047100.69854619
88Wnt signaling pathway_Homo sapiens_hsa043100.69618839
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69176051
90Vitamin B6 metabolism_Homo sapiens_hsa007500.67708758
91GnRH signaling pathway_Homo sapiens_hsa049120.66569176
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66434291
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66034369
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65920675
95cAMP signaling pathway_Homo sapiens_hsa040240.65830985
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65596814
97Estrogen signaling pathway_Homo sapiens_hsa049150.64288262
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64283354
99Gastric acid secretion_Homo sapiens_hsa049710.62449669
100Colorectal cancer_Homo sapiens_hsa052100.61424199
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60994221
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60530303
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58425296
104Systemic lupus erythematosus_Homo sapiens_hsa053220.55035295
105Hedgehog signaling pathway_Homo sapiens_hsa043400.53854301
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53340002
107Thyroid cancer_Homo sapiens_hsa052160.52300906
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51823818
109Glutathione metabolism_Homo sapiens_hsa004800.51435870
110Axon guidance_Homo sapiens_hsa043600.50998975
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.50958476
112Tryptophan metabolism_Homo sapiens_hsa003800.50843365
113Glioma_Homo sapiens_hsa052140.50682284
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50501921
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.49934873
116Carbon metabolism_Homo sapiens_hsa012000.47405124
117VEGF signaling pathway_Homo sapiens_hsa043700.46869631
118p53 signaling pathway_Homo sapiens_hsa041150.45794437
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45013472
120Biosynthesis of amino acids_Homo sapiens_hsa012300.44513698
121Type I diabetes mellitus_Homo sapiens_hsa049400.42842210
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42536936
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42222169
124Epstein-Barr virus infection_Homo sapiens_hsa051690.41491217
125Thyroid hormone synthesis_Homo sapiens_hsa049180.40314113
126Regulation of autophagy_Homo sapiens_hsa041400.40147518
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.39100200
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38862730
129Linoleic acid metabolism_Homo sapiens_hsa005910.38078442
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38056610
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32831915
132Steroid biosynthesis_Homo sapiens_hsa001000.32490404
133Primary immunodeficiency_Homo sapiens_hsa053400.32178500
134Fatty acid metabolism_Homo sapiens_hsa012120.30585115
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28894014
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.28440026
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24097894
138Caffeine metabolism_Homo sapiens_hsa002320.23434334
139Ether lipid metabolism_Homo sapiens_hsa005650.23421650
140Arginine and proline metabolism_Homo sapiens_hsa003300.21255018
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20985864
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20755671
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.20064211
144Chemical carcinogenesis_Homo sapiens_hsa052040.18705523
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14544553

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