FAM216B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UTP metabolic process (GO:0046051)9.66476955
2nucleoside diphosphate phosphorylation (GO:0006165)9.32564782
3left/right axis specification (GO:0070986)9.29711319
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.99875078
5CTP metabolic process (GO:0046036)7.48564497
6CTP biosynthetic process (GO:0006241)7.48564497
7guanosine-containing compound biosynthetic process (GO:1901070)7.48354622
8primary alcohol catabolic process (GO:0034310)7.08820014
9pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)6.87407944
10pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)6.70340285
11vitamin transmembrane transport (GO:0035461)6.45301765
12microtubule bundle formation (GO:0001578)5.98894741
13ethanol metabolic process (GO:0006067)5.96913224
14diterpenoid biosynthetic process (GO:0016102)5.79353637
15one-carbon compound transport (GO:0019755)5.70798868
16motile cilium assembly (GO:0044458)5.62640890
17response to xenobiotic stimulus (GO:0009410)5.58241461
18pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)5.49660120
19cilium organization (GO:0044782)5.34137345
20intraciliary transport (GO:0042073)5.24700089
21regulation of macrophage chemotaxis (GO:0010758)5.19009400
22regulation of glucose import in response to insulin stimulus (GO:2001273)5.15860007
23nucleotide phosphorylation (GO:0046939)5.10509590
24pyrimidine-containing compound transmembrane transport (GO:0072531)5.05798062
25centriole assembly (GO:0098534)5.03542755
26tolerance induction (GO:0002507)5.02788077
27protein localization to cilium (GO:0061512)5.01865999
28pyrimidine nucleoside triphosphate metabolic process (GO:0009147)5.00922312
29cilium assembly (GO:0042384)4.77711513
30regulation of interleukin-5 production (GO:0032674)4.74843945
31lung epithelium development (GO:0060428)4.71617139
32regulation of microtubule-based movement (GO:0060632)4.71372644
33regulation of mononuclear cell migration (GO:0071675)4.65835878
34negative regulation of T cell differentiation in thymus (GO:0033085)4.60168083
35nucleoside diphosphate metabolic process (GO:0009132)4.55790920
36establishment of apical/basal cell polarity (GO:0035089)4.47743238
37ethanol oxidation (GO:0006069)4.44452865
38pyrimidine ribonucleoside biosynthetic process (GO:0046132)4.37303674
39regulation of interleukin-13 production (GO:0032656)4.33069962
40sperm capacitation (GO:0048240)4.32931599
41cilium morphogenesis (GO:0060271)4.23683803
42pyrimidine ribonucleotide biosynthetic process (GO:0009220)4.19366919
43regulation of germinal center formation (GO:0002634)4.16309000
44cellular component assembly involved in morphogenesis (GO:0010927)4.15818460
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.13175043
46microtubule-based movement (GO:0007018)4.03862366
47axon ensheathment in central nervous system (GO:0032291)4.02329092
48central nervous system myelination (GO:0022010)4.02329092
49terpenoid biosynthetic process (GO:0016114)4.00321824
50retinoic acid metabolic process (GO:0042573)3.95406251
51establishment or maintenance of monopolar cell polarity (GO:0061339)3.89541218
52establishment of monopolar cell polarity (GO:0061162)3.89541218
53pyrimidine ribonucleotide metabolic process (GO:0009218)3.88678288
54positive regulation of cellular response to insulin stimulus (GO:1900078)3.85760428
55cytoplasmic microtubule organization (GO:0031122)3.72919376
56cell projection assembly (GO:0030031)3.66585083
57multicellular organismal aging (GO:0010259)3.56655534
58brain morphogenesis (GO:0048854)3.51813289
59otic vesicle formation (GO:0030916)3.44322389
60pyrimidine ribonucleoside metabolic process (GO:0046131)3.42478558
61oxygen transport (GO:0015671)3.41485960
62exogenous drug catabolic process (GO:0042738)3.40736801
63microtubule depolymerization (GO:0007019)3.40517651
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.36607276
65establishment of tissue polarity (GO:0007164)3.31039841
66establishment of planar polarity (GO:0001736)3.31039841
67purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26499994
68positive regulation of meiosis (GO:0045836)3.25640776
69positive regulation of smoothened signaling pathway (GO:0045880)3.24038758
70microtubule polymerization or depolymerization (GO:0031109)3.22403837
71primary alcohol metabolic process (GO:0034308)3.19636459
72heart valve formation (GO:0003188)3.17594469
73glutathione derivative metabolic process (GO:1901685)3.13668432
74glutathione derivative biosynthetic process (GO:1901687)3.13668432
75O-glycan processing (GO:0016266)3.12284364
76retinol metabolic process (GO:0042572)3.09817616
77gas transport (GO:0015669)3.08727221
78grooming behavior (GO:0007625)3.08190932
79pyrimidine nucleotide biosynthetic process (GO:0006221)3.06362899
80regulation of tolerance induction (GO:0002643)3.05320456
81negative regulation of inclusion body assembly (GO:0090084)3.05307546
82embryonic camera-type eye development (GO:0031076)3.04304549
83hydrogen peroxide biosynthetic process (GO:0050665)3.02767448
84embryonic digestive tract development (GO:0048566)2.99066302
85negative regulation of B cell mediated immunity (GO:0002713)2.97883904
86negative regulation of immunoglobulin mediated immune response (GO:0002890)2.97883904
87positive regulation of meiotic cell cycle (GO:0051446)2.97653464
88left/right pattern formation (GO:0060972)2.88759565
89apical protein localization (GO:0045176)2.87801263
90positive regulation of protein autophosphorylation (GO:0031954)2.87094175
91lateral sprouting from an epithelium (GO:0060601)2.87052849
92eye photoreceptor cell differentiation (GO:0001754)2.85717252
93photoreceptor cell differentiation (GO:0046530)2.85717252
94epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.85144690
95microtubule-based process (GO:0007017)2.84298749
96centriole replication (GO:0007099)2.83285781
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82125295
98protein palmitoylation (GO:0018345)2.82032869
99glomerular epithelial cell development (GO:0072310)2.81904335
100pyrimidine nucleoside biosynthetic process (GO:0046134)2.81224821
101hair follicle development (GO:0001942)2.80338205
102smoothened signaling pathway (GO:0007224)2.79686781
103aldehyde catabolic process (GO:0046185)2.79043478
104retinal rod cell development (GO:0046548)2.78678714
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77506042
106carnitine metabolic process (GO:0009437)2.76077398
107sperm motility (GO:0030317)2.74749435
108nucleoside triphosphate biosynthetic process (GO:0009142)2.73990697
109positive regulation of extracellular matrix organization (GO:1903055)2.70857859
110multicellular organismal water homeostasis (GO:0050891)2.70360036
111regulation of microtubule depolymerization (GO:0031114)2.70351791
112lateral ventricle development (GO:0021670)2.69898972
113reactive oxygen species biosynthetic process (GO:1903409)2.68276415
114drug catabolic process (GO:0042737)2.65665519
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.64592680
116negative regulation of humoral immune response (GO:0002921)2.64457557
117organelle assembly (GO:0070925)2.63075133
118establishment of protein localization to mitochondrial membrane (GO:0090151)2.62824794
119regulation of mesenchymal cell apoptotic process (GO:2001053)2.59805887
120cellular response to nicotine (GO:0071316)2.57671236
121regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.55313971
122dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.54865564
123regulation of male gonad development (GO:2000018)2.54223292
124endocardial cushion morphogenesis (GO:0003203)2.51152605
125polyol transport (GO:0015791)2.50792517
126calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50472157
127heart looping (GO:0001947)2.49868422
128phosphatidylcholine biosynthetic process (GO:0006656)2.49714811
129iron ion import (GO:0097286)2.49424090
130regulation of cilium movement (GO:0003352)2.48252829
131progesterone metabolic process (GO:0042448)2.48136455
132excretion (GO:0007588)2.47274198
133hydrogen peroxide catabolic process (GO:0042744)2.47111142
134regulation of autophagic vacuole assembly (GO:2000785)2.42463929
135regulation of apoptotic cell clearance (GO:2000425)2.41549850
136hypotonic response (GO:0006971)2.40910469
137determination of left/right symmetry (GO:0007368)2.39967852
138cerebral cortex neuron differentiation (GO:0021895)2.37570107
139negative regulation of astrocyte differentiation (GO:0048712)2.37236814
140regulation of phospholipase A2 activity (GO:0032429)2.36200214
141developmental induction (GO:0031128)2.34985917
142regulation of pigment cell differentiation (GO:0050932)2.34445441
143CDP-diacylglycerol biosynthetic process (GO:0016024)2.33886245
144regulation of response to osmotic stress (GO:0047484)2.32442713
145asymmetric protein localization (GO:0008105)2.32202501
146cell-cell signaling involved in cell fate commitment (GO:0045168)2.31634514
147determination of bilateral symmetry (GO:0009855)2.30586433
148phosphatidylcholine acyl-chain remodeling (GO:0036151)2.30564821
149specification of symmetry (GO:0009799)2.28067858
150oligodendrocyte differentiation (GO:0048709)2.20941962
151pyrimidine-containing compound biosynthetic process (GO:0072528)2.20016234
152limb bud formation (GO:0060174)2.19313035
153regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.17218069
154ADP metabolic process (GO:0046031)2.15487176
155cellular response to sterol (GO:0036315)2.13133667
156positive regulation of tolerance induction (GO:0002645)2.12456241
157epithelial structure maintenance (GO:0010669)2.12193404
158regulation of inclusion body assembly (GO:0090083)2.10708648
159negative regulation of oligodendrocyte differentiation (GO:0048715)2.09874610
160regulation of protein autophosphorylation (GO:0031952)2.07613476
161actin filament polymerization (GO:0030041)2.05666615
162cilium movement (GO:0003341)16.0662543
163axoneme assembly (GO:0035082)13.8437824
164axonemal dynein complex assembly (GO:0070286)12.5354651
165GTP biosynthetic process (GO:0006183)11.3521818
166epithelial cilium movement (GO:0003351)11.2640010
167ventricular system development (GO:0021591)10.9381210
168cilium or flagellum-dependent cell motility (GO:0001539)10.8486848
169UTP biosynthetic process (GO:0006228)10.1667255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.61439081
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.47389680
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.54373899
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.47772374
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.28850797
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.19953579
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.15730759
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60813144
9AR_21572438_ChIP-Seq_LNCaP_Human2.47921448
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27558391
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.24422428
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.18931289
13AHR_22903824_ChIP-Seq_MCF-7_Human2.09213719
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05131607
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03987685
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03399885
17EZH2_22144423_ChIP-Seq_EOC_Human1.91695290
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88774899
19FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.88361954
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86918565
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82923505
22VDR_22108803_ChIP-Seq_LS180_Human1.82817149
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.82423717
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80449280
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80300459
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.80117609
27STAT1_20625510_ChIP-Seq_HELA_Human1.76758585
28TP63_23658742_ChIP-Seq_EP156T_Human1.75131738
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.74995574
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74107661
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72454096
32P300_19829295_ChIP-Seq_ESCs_Human1.70827457
33SMAD4_21799915_ChIP-Seq_A2780_Human1.70756805
34BCAT_22108803_ChIP-Seq_LS180_Human1.68908521
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.68827504
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.67044329
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.64960526
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64564323
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63677730
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59992987
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59989312
42RNF2_27304074_Chip-Seq_NSC_Mouse1.59508014
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58729805
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.58472705
45SMC4_20622854_ChIP-Seq_HELA_Human1.57767113
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57394565
47DROSHA_22980978_ChIP-Seq_HELA_Human1.55523846
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52980116
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52980116
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52190372
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52053138
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.52038476
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48591490
54KLF5_25053715_ChIP-Seq_YYC3_Human1.48052404
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47331452
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45161196
57SOX2_20726797_ChIP-Seq_SW620_Human1.44943489
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44155513
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44029917
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.43445901
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42544189
62ETV1_20927104_ChIP-Seq_GIST48_Human1.42278961
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38794540
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38573458
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.37818020
66SMRT_27268052_Chip-Seq_Bcells_Human1.37624153
67ER_23166858_ChIP-Seq_MCF-7_Human1.37107780
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36833710
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36627002
70TP63_22573176_ChIP-Seq_HFKS_Human1.36327910
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35732042
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.35512266
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34828030
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34565157
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.34011981
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33930372
77GBX2_23144817_ChIP-Seq_PC3_Human1.33075966
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.33004809
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31572471
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.31292683
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31002197
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30991585
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.30393280
84FUS_26573619_Chip-Seq_HEK293_Human1.30206269
85PHF8_20622853_ChIP-Seq_HELA_Human1.29694832
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28190838
87GATA1_19941826_ChIP-Seq_K562_Human1.27645298
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26827532
89TAF15_26573619_Chip-Seq_HEK293_Human1.26793163
90HNFA_21074721_ChIP-Seq_CACO-2_Human1.26629606
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26099186
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25721290
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25572258
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24765520
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24634100
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24590852
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24590852
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23647088
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20644313
100RXR_22108803_ChIP-Seq_LS180_Human1.20344906
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.20147354
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.20147013
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.19574874
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19502197
105TCF4_22108803_ChIP-Seq_LS180_Human1.19239833
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19016021
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18931189
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18409762
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18284036
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17879399
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.17709378
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.17347983
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15843856
114RBPJ_21746931_ChIP-Seq_IB4_Human1.15725898
115GATA4_25053715_ChIP-Seq_YYC3_Human1.14764646
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14489968
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.14308287
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13921981
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.12965418
120FLI1_27457419_Chip-Seq_LIVER_Mouse1.12817680
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12606340
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11645257
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.09888392
124GATA3_24758297_ChIP-Seq_MCF-7_Human1.08304122
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.08285726
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.07802110
127SMAD4_21741376_ChIP-Seq_HESCs_Human1.07147043
128CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07045618
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06646926
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06225457
131NFYA_21822215_ChIP-Seq_K562_Human1.06055405
132FOXA2_19822575_ChIP-Seq_HepG2_Human1.05901754
133RING1B_27294783_Chip-Seq_ESCs_Mouse1.05035029
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.04927817
135GATA6_21074721_ChIP-Seq_CACO-2_Human1.04858282
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.04198691
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03565088
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.03247136
139NFYB_21822215_ChIP-Seq_K562_Human1.01234237
140EP300_21415370_ChIP-Seq_HL-1_Mouse1.00940205
141FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00523558
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00426975
143ZFX_18555785_Chip-Seq_ESCs_Mouse1.00413086
144CJUN_26792858_Chip-Seq_BT549_Human1.00013023
145AR_25329375_ChIP-Seq_VCAP_Human0.99936993
146CEBPB_22108803_ChIP-Seq_LS180_Human0.99835243
147TP53_16413492_ChIP-PET_HCT116_Human0.98854876
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98732508
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.98507877
150TBL1_22424771_ChIP-Seq_293T_Human0.98178354
151SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98122311
152STAT3_23295773_ChIP-Seq_U87_Human0.97712276
153SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96929421
154TP53_18474530_ChIP-ChIP_U2OS_Human0.96729934
155LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96702385
156RUNX2_22187159_ChIP-Seq_PCA_Human0.96167308
157REST_21632747_ChIP-Seq_MESCs_Mouse0.95889519
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.95397171
159SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95335401
160EWS_26573619_Chip-Seq_HEK293_Human0.94864401
161RING1B_27294783_Chip-Seq_NPCs_Mouse0.94729586
162P53_22387025_ChIP-Seq_ESCs_Mouse0.94641974
163CTCF_20526341_ChIP-Seq_ESCs_Human0.94328240
164GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94326784
165RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93466567
166CTCF_27219007_Chip-Seq_Bcells_Human0.92547630
167CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91652827
168TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90950348
169GATA2_19941826_ChIP-Seq_K562_Human0.88421509
170SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88308559
171SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84843536
172WDR5_24793694_ChIP-Seq_LNCAP_Human0.83443752
173CREB1_26743006_Chip-Seq_LNCaP_Human0.83281758
174EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82479128
175TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82093938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.53398158
2MP0002132_abnormal_respiratory_system5.94472673
3MP0008004_abnormal_stomach_pH5.88729548
4MP0005623_abnormal_meninges_morphology4.31649833
5MP0005646_abnormal_pituitary_gland3.84667488
6MP0004043_abnormal_pH_regulation3.84579880
7MP0002653_abnormal_ependyma_morphology3.82735076
8MP0001440_abnormal_grooming_behavior3.71467602
9MP0008789_abnormal_olfactory_epithelium3.08558648
10MP0000566_synostosis3.03051691
11MP0004133_heterotaxia2.66601185
12MP0000383_abnormal_hair_follicle2.42339102
13MP0002736_abnormal_nociception_after2.25286993
14MP0010678_abnormal_skin_adnexa2.14366927
15MP0003690_abnormal_glial_cell2.11911730
16MP0004019_abnormal_vitamin_homeostasis2.11542474
17MP0009046_muscle_twitch2.10276683
18MP0001501_abnormal_sleep_pattern2.10091013
19MP0005377_hearing/vestibular/ear_phenot2.07801426
20MP0003878_abnormal_ear_physiology2.07801426
21MP0003656_abnormal_erythrocyte_physiolo2.01783627
22MP0005499_abnormal_olfactory_system2.00066999
23MP0005394_taste/olfaction_phenotype2.00066999
24MP0002282_abnormal_trachea_morphology1.98666404
25MP0001968_abnormal_touch/_nociception1.98013243
26MP0002160_abnormal_reproductive_system1.77296036
27MP0001765_abnormal_ion_homeostasis1.77283559
28MP0004858_abnormal_nervous_system1.74828891
29MP0002249_abnormal_larynx_morphology1.72228391
30MP0002735_abnormal_chemical_nociception1.63351594
31MP0004859_abnormal_synaptic_plasticity1.61398415
32MP0005083_abnormal_biliary_tract1.59623076
33MP0002928_abnormal_bile_duct1.58374962
34MP0009745_abnormal_behavioral_response1.57224253
35MP0002734_abnormal_mechanical_nocicepti1.57109723
36MP0001485_abnormal_pinna_reflex1.54956710
37MP0000678_abnormal_parathyroid_gland1.52963125
38MP0000778_abnormal_nervous_system1.47435210
39MP0001346_abnormal_lacrimal_gland1.45252495
40MP0003634_abnormal_glial_cell1.45171991
41MP0006276_abnormal_autonomic_nervous1.41410600
42MP0002064_seizures1.37106525
43MP0003937_abnormal_limbs/digits/tail_de1.35959847
44MP0003938_abnormal_ear_development1.35102702
45MP0010234_abnormal_vibrissa_follicle1.34719331
46MP0005388_respiratory_system_phenotype1.33078262
47MP0002133_abnormal_respiratory_system1.33078262
48MP0002572_abnormal_emotion/affect_behav1.32976907
49MP0003635_abnormal_synaptic_transmissio1.28100475
50MP0005395_other_phenotype1.27874003
51MP0005248_abnormal_Harderian_gland1.27116431
52MP0004381_abnormal_hair_follicle1.26886499
53MP0000049_abnormal_middle_ear1.26771984
54MP0003880_abnormal_central_pattern1.21191821
55MP0002638_abnormal_pupillary_reflex1.19599429
56MP0002557_abnormal_social/conspecific_i1.19217506
57MP0004742_abnormal_vestibular_system1.18364704
58MP0005636_abnormal_mineral_homeostasis1.17989241
59MP0000428_abnormal_craniofacial_morphol1.17501359
60MP0005423_abnormal_somatic_nervous1.16734183
61MP0004142_abnormal_muscle_tone1.15999688
62MP0010155_abnormal_intestine_physiology1.15877078
63MP0009384_cardiac_valve_regurgitation1.14984959
64MP0000465_gastrointestinal_hemorrhage1.13377774
65MP0005379_endocrine/exocrine_gland_phen1.12068278
66MP0001851_eye_inflammation1.11372626
67MP0001958_emphysema1.11111512
68MP0005551_abnormal_eye_electrophysiolog1.09464349
69MP0000470_abnormal_stomach_morphology1.08442655
70MP0001177_atelectasis1.08357920
71MP0002272_abnormal_nervous_system1.06219793
72MP0001486_abnormal_startle_reflex1.04984360
73MP0004270_analgesia1.03189426
74MP0002233_abnormal_nose_morphology1.02856970
75MP0002063_abnormal_learning/memory/cond1.02602466
76MP0009780_abnormal_chondrocyte_physiolo1.02569916
77MP0000631_abnormal_neuroendocrine_gland1.02481180
78MP0006292_abnormal_olfactory_placode1.01645840
79MP0001970_abnormal_pain_threshold1.01585633
80MP0001663_abnormal_digestive_system1.00207733
81MP0005408_hypopigmentation0.98182690
82MP0010030_abnormal_orbit_morphology0.97142423
83MP0002168_other_aberrant_phenotype0.96332007
84MP0008872_abnormal_physiological_respon0.94948027
85MP0005164_abnormal_response_to0.94069565
86MP0009250_abnormal_appendicular_skeleto0.92554238
87MP0000681_abnormal_thyroid_gland0.90942626
88MP0001984_abnormal_olfaction0.90662897
89MP0004883_abnormal_blood_vessel0.90465352
90MP0005381_digestive/alimentary_phenotyp0.89914253
91MP0005365_abnormal_bile_salt0.89640088
92MP0000026_abnormal_inner_ear0.89500110
93MP0005503_abnormal_tendon_morphology0.87207746
94MP0001270_distended_abdomen0.85982464
95MP0004885_abnormal_endolymph0.85962264
96MP0003075_altered_response_to0.84796348
97MP0002909_abnormal_adrenal_gland0.84580778
98MP0009643_abnormal_urine_homeostasis0.84207994
99MP0002136_abnormal_kidney_physiology0.83605818
100MP0002067_abnormal_sensory_capabilities0.83113916
101MP0009379_abnormal_foot_pigmentation0.82367642
102MP0005389_reproductive_system_phenotype0.82021454
103MP0003950_abnormal_plasma_membrane0.81421474
104MP0002152_abnormal_brain_morphology0.80724459
105MP0003633_abnormal_nervous_system0.79197197
106MP0004264_abnormal_extraembryonic_tissu0.78898870
107MP0004924_abnormal_behavior0.78591870
108MP0005386_behavior/neurological_phenoty0.78591870
109MP0003303_peritoneal_inflammation0.78576030
110MP0001849_ear_inflammation0.78379412
111MP0005595_abnormal_vascular_smooth0.76841343
112MP0005165_increased_susceptibility_to0.76619276
113MP0004145_abnormal_muscle_electrophysio0.76247767
114MP0002090_abnormal_vision0.75111335
115MP0002405_respiratory_system_inflammati0.74020584
116MP0002938_white_spotting0.72660603
117MP0002876_abnormal_thyroid_physiology0.72279593
118MP0009765_abnormal_xenobiotic_induced0.72009427
119MP0002277_abnormal_respiratory_mucosa0.71882993
120MP0001905_abnormal_dopamine_level0.71625295
121MP0008875_abnormal_xenobiotic_pharmacok0.71500282
122MP0002896_abnormal_bone_mineralization0.71277683
123MP0001963_abnormal_hearing_physiology0.71260292
124MP0005220_abnormal_exocrine_pancreas0.71230479
125MP0004272_abnormal_basement_membrane0.71036811
126MP0003959_abnormal_lean_body0.69739304
127MP0001986_abnormal_taste_sensitivity0.68019021
128MP0002098_abnormal_vibrissa_morphology0.67266913
129MP0003861_abnormal_nervous_system0.66662174
130MP0002295_abnormal_pulmonary_circulatio0.66243030
131MP0002882_abnormal_neuron_morphology0.66242611
132MP0000613_abnormal_salivary_gland0.65555556
133MP0004085_abnormal_heartbeat0.65273016
134MP0001286_abnormal_eye_development0.64772749
135MP0001929_abnormal_gametogenesis0.64661118
136MP0005332_abnormal_amino_acid0.64544683
137MP0003698_abnormal_male_reproductive0.64314509
138MP0005085_abnormal_gallbladder_physiolo0.64295578
139MP0002116_abnormal_craniofacial_bone0.63507985
140MP0002139_abnormal_hepatobiliary_system0.63176981
141MP0005310_abnormal_salivary_gland0.62900202
142MP0003453_abnormal_keratinocyte_physiol0.62280347
143MP0002733_abnormal_thermal_nociception0.61577107
144MP0006082_CNS_inflammation0.61375848
145MP0003122_maternal_imprinting0.61368659
146MP0001756_abnormal_urination0.60462454
147MP0001293_anophthalmia0.60351383
148MP0000749_muscle_degeneration0.60332767
149MP0009703_decreased_birth_body0.59651693
150MP0005253_abnormal_eye_physiology0.59550099
151MP0009763_increased_sensitivity_to0.58850897
152MP0001879_abnormal_lymphatic_vessel0.58552048
153MP0001790_abnormal_immune_system0.56723333
154MP0005387_immune_system_phenotype0.56723333
155MP0001324_abnormal_eye_pigmentation0.55346135
156MP0000467_abnormal_esophagus_morphology0.53139998
157MP0001299_abnormal_eye_distance/0.51514183
158MP0001502_abnormal_circadian_rhythm0.50938512
159MP0001664_abnormal_digestion0.50883121
160MP0003866_abnormal_defecation0.48848132
161MP0003806_abnormal_nucleotide_metabolis0.45648038
162MP0004782_abnormal_surfactant_physiolog0.45337537
163MP0001944_abnormal_pancreas_morphology0.43663615
164MP0002084_abnormal_developmental_patter0.42992683
165MP0002135_abnormal_kidney_morphology0.42769688
166MP0003890_abnormal_embryonic-extraembry0.42513442
167MP0005023_abnormal_wound_healing0.42024402

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.81228780
2Abnormal respiratory epithelium morphology (HP:0012253)8.81228780
3Chronic bronchitis (HP:0004469)7.96828538
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.67210110
5Absent/shortened dynein arms (HP:0200106)6.67210110
6Bronchiectasis (HP:0002110)5.74049721
7Pancreatic fibrosis (HP:0100732)4.76386170
8True hermaphroditism (HP:0010459)4.52718292
9Recurrent sinusitis (HP:0011108)4.16570575
10Nasal polyposis (HP:0100582)3.99741505
11Male infertility (HP:0003251)3.80165484
12Bronchitis (HP:0012387)3.76794239
13Bile duct proliferation (HP:0001408)3.57444361
14Abnormal biliary tract physiology (HP:0012439)3.57444361
15Tubulointerstitial nephritis (HP:0001970)3.46548430
16Chronic hepatic failure (HP:0100626)3.39600467
17Abnormality of the nasal mucosa (HP:0000433)3.37617085
18Pancreatic cysts (HP:0001737)3.36228103
19Chronic sinusitis (HP:0011109)3.28637423
20Nephronophthisis (HP:0000090)3.22137404
21Tubular atrophy (HP:0000092)3.13153121
22Chronic otitis media (HP:0000389)3.10794086
23Abnormality of midbrain morphology (HP:0002418)3.06990022
24Molar tooth sign on MRI (HP:0002419)3.06990022
25Abnormality of dentin (HP:0010299)2.98459414
26Cystic liver disease (HP:0006706)2.93027495
27Median cleft lip (HP:0000161)2.91091000
28Neoplasm of head and neck (HP:0012288)2.86661866
29Esophageal neoplasm (HP:0100751)2.86661866
30Hyperactive renin-angiotensin system (HP:0000841)2.81554729
31Occipital encephalocele (HP:0002085)2.81396434
32Recurrent otitis media (HP:0000403)2.80436968
33Postaxial foot polydactyly (HP:0001830)2.76335491
34Abdominal situs inversus (HP:0003363)2.69035776
35Abnormality of abdominal situs (HP:0011620)2.69035776
36Congenital hepatic fibrosis (HP:0002612)2.53241135
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.52946706
38Abnormality of the renal medulla (HP:0100957)2.46294753
39Abnormal sex determination (HP:0012244)2.37244399
40Sex reversal (HP:0012245)2.37244399
41Medial flaring of the eyebrow (HP:0010747)2.36688790
42Concave nail (HP:0001598)2.32598573
43Broad distal phalanx of finger (HP:0009836)2.30569819
44Anencephaly (HP:0002323)2.28263396
45Polydipsia (HP:0001959)2.27204665
46Abnormal drinking behavior (HP:0030082)2.27204665
47Stage 5 chronic kidney disease (HP:0003774)2.25457693
48Gait imbalance (HP:0002141)2.24849125
49Congenital primary aphakia (HP:0007707)2.18566233
50Fibular hypoplasia (HP:0003038)2.18493875
51Recurrent bronchitis (HP:0002837)2.12914281
52Bell-shaped thorax (HP:0001591)2.04775447
53Tubulointerstitial abnormality (HP:0001969)2.02828659
54Supernumerary spleens (HP:0009799)2.00573721
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.9543223
56Abnormal respiratory motile cilium physiology (HP:0012261)12.3994524
57Abnormal ciliary motility (HP:0012262)11.4430353
58Rhinitis (HP:0012384)11.1689750
59Preaxial hand polydactyly (HP:0001177)1.98647444
60Sclerocornea (HP:0000647)1.98582404
61Male pseudohermaphroditism (HP:0000037)1.97897201
62Abnormality of the dental root (HP:0006486)1.97021993
63Taurodontia (HP:0000679)1.97021993
64Abnormality of permanent molar morphology (HP:0011071)1.97021993
65Back pain (HP:0003418)1.96649344
66Genital tract atresia (HP:0001827)1.89049963
67Absent frontal sinuses (HP:0002688)1.88425734
68Nephrogenic diabetes insipidus (HP:0009806)1.87153047
69Neonatal short-limb short stature (HP:0008921)1.84438420
70Abnormality of molar (HP:0011077)1.82363199
71Abnormality of molar morphology (HP:0011070)1.82363199
72Abnormality of the dental pulp (HP:0006479)1.80909905
73Abnormality of the renal cortex (HP:0011035)1.79912638
74Decreased circulating renin level (HP:0003351)1.76315775
75Postaxial hand polydactyly (HP:0001162)1.75754722
76Infertility (HP:0000789)1.75163176
77Atelectasis (HP:0100750)1.70919536
78Asplenia (HP:0001746)1.69059612
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.67383265
80Renal salt wasting (HP:0000127)1.65841082
81Furrowed tongue (HP:0000221)1.64427121
82Vaginal atresia (HP:0000148)1.58907791
83Bronchomalacia (HP:0002780)1.57699070
84Polyuria (HP:0000103)1.49317291
85Hyperkalemia (HP:0002153)1.47998438
86Facial cleft (HP:0002006)1.47751324
87Poor coordination (HP:0002370)1.47721817
88Transposition of the great arteries (HP:0001669)1.44752685
89Abnormal connection of the cardiac segments (HP:0011545)1.44752685
90Abnormal ventriculo-arterial connection (HP:0011563)1.44752685
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.44723061
92Oculomotor apraxia (HP:0000657)1.43984921
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.43831469
94Nephropathy (HP:0000112)1.43312520
95Ectopic anus (HP:0004397)1.42309586
96Hypotelorism (HP:0000601)1.40470805
97Abnormal urine output (HP:0012590)1.39464450
98Hyperaldosteronism (HP:0000859)1.39347618
99Aplasia/Hypoplasia of the fibula (HP:0006492)1.38123692
100Megalencephaly (HP:0001355)1.33206486
101Glucose intolerance (HP:0000833)1.28693660
102Abnormal umbilical cord blood vessels (HP:0011403)1.28555390
103Single umbilical artery (HP:0001195)1.28555390
104Abnormality of the fetal cardiovascular system (HP:0010948)1.28555390
105Aplasia/Hypoplasia of the lens (HP:0008063)1.27942499
106Abnormality of renin-angiotensin system (HP:0000847)1.27397670
107Metaphyseal dysplasia (HP:0100255)1.26953615
108Short nail (HP:0001799)1.25232591
109Abnormality of chloride homeostasis (HP:0011422)1.25069253
110Short thorax (HP:0010306)1.24565715
111Bifid tongue (HP:0010297)1.24293016
112Abnormality of renal excretion (HP:0011036)1.20169000
113Intellectual disability, moderate (HP:0002342)1.18879979
114Hypokalemic alkalosis (HP:0001949)1.17220915
115Cone-rod dystrophy (HP:0000548)1.17165463
116Optic nerve coloboma (HP:0000588)1.16739351
117Hip dysplasia (HP:0001385)1.16451407
118Maternal diabetes (HP:0009800)1.16231106
119Abnormality of the distal phalanges of the toes (HP:0010182)1.15981806
120Polycystic kidney dysplasia (HP:0000113)1.15758747
121Decreased central vision (HP:0007663)1.13983763
122Abnormality of the frontal sinuses (HP:0002687)1.13670851
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.13348362
124Hand muscle atrophy (HP:0009130)1.10879902
125Polycystic ovaries (HP:0000147)1.10152683
126Tachypnea (HP:0002789)1.09993533
127Bifid scrotum (HP:0000048)1.09453773
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.04020883
129Tubulointerstitial fibrosis (HP:0005576)1.03325089
130Hyponatremia (HP:0002902)1.02659912
131Lip pit (HP:0100267)0.97721617
132Fetal akinesia sequence (HP:0001989)0.96410821
133Aplasia of the musculature (HP:0100854)0.95611034
134Obstructive sleep apnea (HP:0002870)0.94871052
135Abnormality of monocarboxylic acid metabolism (HP:0010996)0.93601121
136Retinitis pigmentosa (HP:0000510)0.93529533
137Popliteal pterygium (HP:0009756)0.93389211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.63137018
2PNCK7.78193088
3EPHA24.69061171
4MST43.37646158
5SIK12.67069743
6GRK12.59275034
7MAPKAPK32.43418670
8WEE12.10810680
9VRK12.10162927
10NME12.05971910
11STK241.93027839
12NTRK21.89980168
13SMG11.88357226
14EEF2K1.87120400
15TTK1.76773674
16CASK1.74864403
17DMPK1.69023960
18MAP3K31.57354562
19PAK21.54417252
20MKNK21.37378684
21CDK31.33239459
22LMTK21.24541083
23EPHB11.18543270
24NEK61.18342576
25ROCK21.14813355
26CDK81.12113348
27DAPK21.06646135
28FES1.05251848
29EPHA31.04930817
30STK101.02641141
31MAP3K71.02559061
32MST1R1.02447704
33SCYL21.01603699
34PRKCG1.00269434
35GSK3A0.99849686
36MAP2K20.92494208
37RPS6KA20.91672104
38RIPK40.90872834
39ERBB30.89391849
40TLK10.88308188
41MAP3K40.87295893
42MARK10.87006720
43TESK10.85943246
44MAP3K90.84697160
45ROCK10.83958964
46BMPR1B0.82058874
47NTRK30.81866288
48MARK20.80159428
49BRSK20.79814630
50TBK10.78512284
51MUSK0.76921122
52CAMKK10.75427330
53PRKCI0.74733469
54PTK2B0.73400765
55EPHA40.73096949
56STK380.72808936
57TEC0.72652806
58PRKCE0.72083180
59PHKG20.70730305
60PHKG10.70730305
61LATS10.66302256
62MKNK10.66193034
63ERBB20.63960889
64CAMK2A0.63861419
65GRK50.63107190
66ADRBK20.60602908
67PAK30.60385580
68MAPK120.59150144
69MAP3K120.58645459
70PRKG10.58315698
71LRRK20.56374607
72MINK10.56263173
73ICK0.55598471
74MAP2K70.55102144
75SGK2230.54322576
76SGK4940.54322576
77ADRBK10.53524104
78OXSR10.52131986
79STK38L0.50890752
80TNIK0.50402107
81IRAK10.50091315
82CAMK2B0.49712339
83RPS6KA50.48573079
84FGR0.47219757
85MYLK0.46466949
86PRKACA0.46198122
87DYRK1A0.46073653
88ITK0.46051280
89STK160.45067066
90PRKCQ0.43551212
91FER0.43153608
92RPS6KL10.42604083
93RPS6KC10.42604083
94PRKCD0.42173540
95DYRK20.42052540
96CDK50.41447842
97SRC0.41346523
98HIPK20.40768021
99PRKG20.40292348
100CSNK1E0.38635732
101AKT20.38156384
102MAPKAPK20.38049746
103TRIB30.37780996
104FRK0.37702378
105MOS0.37253225
106PKN10.37130881
107RPS6KB20.37065915
108INSRR0.36675988
109FGFR30.36649098
110PTK20.36168949
111SGK10.35929477
112AURKA0.35603291
113PRKACG0.35162430
114CAMK2D0.34067297
115DYRK1B0.33898428
116CSK0.33869865
117MAPKAPK50.33452568
118GRK60.33172378
119CDC42BPA0.32987640
120RPS6KA60.32856961
121NEK90.32828630
122RIPK10.32330847
123DYRK30.32232105
124NLK0.32071067
125BCR0.32035773
126TGFBR10.31944535
127STK110.31924164
128PDPK10.31868077
129PRKAA20.31805500
130TYRO30.31656296
131TAOK10.30862982
132CAMK2G0.30150280
133TIE10.30090363
134PRKD10.29905732
135SGK20.29586638
136MAP3K20.29268027
137TRPM70.29044569
138ABL10.28868860
139SIK20.28686121
140MAPK70.28167438
141CSNK1G10.27651022
142NTRK10.27217421
143PRKDC0.26994608
144CAMKK20.26515106
145PRKCH0.25873230
146MAP2K40.25838272
147ARAF0.25242568
148CDK60.25122160
149PAK40.24712966
150TYK20.23897241
151MET0.20824720
152PRKCA0.19471620
153FYN0.19383131
154TSSK60.18182404
155RET0.17350472
156CCNB10.16764531
157PTK60.16459692
158PASK0.15948864
159PBK0.15638124
160EGFR0.14893776
161MATK0.13134800
162PLK10.12251497
163STK390.11755497
164PRKCZ0.10282013
165MAP3K60.09898454

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.83709986
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.75645072
3Tyrosine metabolism_Homo sapiens_hsa003503.72533533
4beta-Alanine metabolism_Homo sapiens_hsa004102.97973723
5Huntingtons disease_Homo sapiens_hsa050162.97213914
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.41402326
7Caffeine metabolism_Homo sapiens_hsa002322.38063098
8Gastric acid secretion_Homo sapiens_hsa049712.19389496
9PPAR signaling pathway_Homo sapiens_hsa033202.15320013
10Vitamin B6 metabolism_Homo sapiens_hsa007502.10468659
11Butanoate metabolism_Homo sapiens_hsa006502.03877711
12Linoleic acid metabolism_Homo sapiens_hsa005911.96525763
13GABAergic synapse_Homo sapiens_hsa047271.93686368
14Nicotine addiction_Homo sapiens_hsa050331.87421076
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83010239
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68136671
17ABC transporters_Homo sapiens_hsa020101.60593992
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59879223
19Amphetamine addiction_Homo sapiens_hsa050311.59335347
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57104002
21Nitrogen metabolism_Homo sapiens_hsa009101.56659729
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56578354
23Tight junction_Homo sapiens_hsa045301.48814302
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47108657
25Glutamatergic synapse_Homo sapiens_hsa047241.46767384
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45517709
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45053185
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.43521467
29Circadian entrainment_Homo sapiens_hsa047131.42637931
30Oxidative phosphorylation_Homo sapiens_hsa001901.38021637
31Cocaine addiction_Homo sapiens_hsa050301.36314974
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35351138
33Olfactory transduction_Homo sapiens_hsa047401.34233457
34Phototransduction_Homo sapiens_hsa047441.33420449
35Estrogen signaling pathway_Homo sapiens_hsa049151.33075043
36Prion diseases_Homo sapiens_hsa050201.31685087
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31559817
38Insulin secretion_Homo sapiens_hsa049111.29665862
39Morphine addiction_Homo sapiens_hsa050321.26240801
40Circadian rhythm_Homo sapiens_hsa047101.24156181
41Fatty acid degradation_Homo sapiens_hsa000711.20787641
42Alzheimers disease_Homo sapiens_hsa050101.17133772
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15888244
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14014356
45Ether lipid metabolism_Homo sapiens_hsa005651.12225544
46Taste transduction_Homo sapiens_hsa047421.11771507
47Calcium signaling pathway_Homo sapiens_hsa040201.10558024
48Cardiac muscle contraction_Homo sapiens_hsa042601.09865756
49Renin secretion_Homo sapiens_hsa049241.09175574
50Salivary secretion_Homo sapiens_hsa049701.07036755
51Arachidonic acid metabolism_Homo sapiens_hsa005901.05913582
52Fatty acid elongation_Homo sapiens_hsa000621.05361627
53Melanogenesis_Homo sapiens_hsa049161.04702078
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04681427
55Histidine metabolism_Homo sapiens_hsa003401.04331448
56Starch and sucrose metabolism_Homo sapiens_hsa005001.03845404
57cAMP signaling pathway_Homo sapiens_hsa040240.99872677
58Hedgehog signaling pathway_Homo sapiens_hsa043400.99067330
59Bile secretion_Homo sapiens_hsa049760.98239748
60Wnt signaling pathway_Homo sapiens_hsa043100.97004411
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96491394
62Thyroid hormone synthesis_Homo sapiens_hsa049180.95535913
63Serotonergic synapse_Homo sapiens_hsa047260.94504136
64Chemical carcinogenesis_Homo sapiens_hsa052040.94350857
65Dopaminergic synapse_Homo sapiens_hsa047280.93757791
66Ovarian steroidogenesis_Homo sapiens_hsa049130.93150156
67Glutathione metabolism_Homo sapiens_hsa004800.92738894
68Basal cell carcinoma_Homo sapiens_hsa052170.92511748
69Protein export_Homo sapiens_hsa030600.90371056
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87879976
71Parkinsons disease_Homo sapiens_hsa050120.87466678
72Gap junction_Homo sapiens_hsa045400.87334117
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.84817600
74Peroxisome_Homo sapiens_hsa041460.83796918
75Mineral absorption_Homo sapiens_hsa049780.82865177
76Retinol metabolism_Homo sapiens_hsa008300.81086478
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80894875
78GnRH signaling pathway_Homo sapiens_hsa049120.80790719
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80223626
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.78501437
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.77716360
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.77076759
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74860018
84Dorso-ventral axis formation_Homo sapiens_hsa043200.74301150
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72143224
86Cholinergic synapse_Homo sapiens_hsa047250.71393267
87Hepatitis C_Homo sapiens_hsa051600.71175008
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70830435
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70471947
90Dilated cardiomyopathy_Homo sapiens_hsa054140.70020856
91Sphingolipid metabolism_Homo sapiens_hsa006000.69299403
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69136030
93Oxytocin signaling pathway_Homo sapiens_hsa049210.68617350
94Choline metabolism in cancer_Homo sapiens_hsa052310.67878308
95Adherens junction_Homo sapiens_hsa045200.66899278
96Hippo signaling pathway_Homo sapiens_hsa043900.66459958
97Long-term depression_Homo sapiens_hsa047300.66254926
98Notch signaling pathway_Homo sapiens_hsa043300.66207683
99Phagosome_Homo sapiens_hsa041450.62614931
100Complement and coagulation cascades_Homo sapiens_hsa046100.61096768
101Rheumatoid arthritis_Homo sapiens_hsa053230.59011113
102Hematopoietic cell lineage_Homo sapiens_hsa046400.58260510
103Tryptophan metabolism_Homo sapiens_hsa003800.56778076
104Renal cell carcinoma_Homo sapiens_hsa052110.56471357
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.54188958
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53361751
107Collecting duct acid secretion_Homo sapiens_hsa049660.52127870
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52068625
109Axon guidance_Homo sapiens_hsa043600.51909609
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49904946
111Pancreatic secretion_Homo sapiens_hsa049720.48968128
112Long-term potentiation_Homo sapiens_hsa047200.47580026
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46289006
114Propanoate metabolism_Homo sapiens_hsa006400.46052687
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46007633
116Synaptic vesicle cycle_Homo sapiens_hsa047210.45612839
117Pyruvate metabolism_Homo sapiens_hsa006200.45214388
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45139785
119Antigen processing and presentation_Homo sapiens_hsa046120.45108040
120Glycerolipid metabolism_Homo sapiens_hsa005610.42946532
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41379923
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41204759
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40985904
124Purine metabolism_Homo sapiens_hsa002300.40880880
125Type I diabetes mellitus_Homo sapiens_hsa049400.40313649
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40196983
127Allograft rejection_Homo sapiens_hsa053300.39780431
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36865156
129Asthma_Homo sapiens_hsa053100.36360971
130Amoebiasis_Homo sapiens_hsa051460.36178096
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36171429
132Autoimmune thyroid disease_Homo sapiens_hsa053200.35951369
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33311229
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31634951
135Lysosome_Homo sapiens_hsa041420.30905809
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.29927349
137Graft-versus-host disease_Homo sapiens_hsa053320.29641162
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29600506
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.28578828
140Metabolic pathways_Homo sapiens_hsa011000.25557479
141Arginine and proline metabolism_Homo sapiens_hsa003300.24101283
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.23097831
143Vitamin digestion and absorption_Homo sapiens_hsa049770.21060622
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20040284
145Insulin resistance_Homo sapiens_hsa049310.20010815
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.17251529
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.15489303
148Staphylococcus aureus infection_Homo sapiens_hsa051500.14800121
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13128996
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11504248
151Prostate cancer_Homo sapiens_hsa052150.08318552
152Regulation of autophagy_Homo sapiens_hsa041400.06023097

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