FAM219A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.57561906
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.15157800
3locomotory exploration behavior (GO:0035641)5.99236505
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51346887
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38362415
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.11132775
7vocalization behavior (GO:0071625)5.06583643
8glutamate secretion (GO:0014047)5.06014033
9regulation of synaptic vesicle exocytosis (GO:2000300)5.05883252
10synaptic vesicle exocytosis (GO:0016079)5.00264883
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92855931
12regulation of glutamate receptor signaling pathway (GO:1900449)4.68979762
13layer formation in cerebral cortex (GO:0021819)4.53957376
14regulation of synaptic vesicle transport (GO:1902803)4.51328596
15regulation of synapse structural plasticity (GO:0051823)4.47766227
16neurotransmitter secretion (GO:0007269)4.37249842
17exploration behavior (GO:0035640)4.37082065
18regulation of neuronal synaptic plasticity (GO:0048168)4.36687865
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.26390353
20proline transport (GO:0015824)4.22583920
21cerebellar granule cell differentiation (GO:0021707)4.19311734
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.19188161
23protein localization to synapse (GO:0035418)4.17563983
24gamma-aminobutyric acid transport (GO:0015812)4.10891571
25neuronal action potential propagation (GO:0019227)4.07953774
26sodium ion export (GO:0071436)4.06730618
27cellular potassium ion homeostasis (GO:0030007)4.04590386
28dendritic spine morphogenesis (GO:0060997)3.94681011
29glycine transport (GO:0015816)3.92218264
30activation of protein kinase A activity (GO:0034199)3.83894145
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74563535
32neurotransmitter-gated ion channel clustering (GO:0072578)3.70115193
33neuron cell-cell adhesion (GO:0007158)3.68292670
34neuromuscular process controlling balance (GO:0050885)3.67029464
35synaptic transmission, glutamatergic (GO:0035249)3.66697101
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65584585
37long-term memory (GO:0007616)3.65200458
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.59460815
39establishment of mitochondrion localization (GO:0051654)3.58690879
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52370461
41positive regulation of membrane potential (GO:0045838)3.50569504
42glutamate receptor signaling pathway (GO:0007215)3.49006964
43cell communication by electrical coupling (GO:0010644)3.48923741
44neurofilament cytoskeleton organization (GO:0060052)3.45805803
45neurotransmitter transport (GO:0006836)3.45422351
46regulation of ARF protein signal transduction (GO:0032012)3.45412386
47synaptic vesicle endocytosis (GO:0048488)3.42962431
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39371715
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38031111
50neuromuscular process controlling posture (GO:0050884)3.35748760
51neuron-neuron synaptic transmission (GO:0007270)3.35623769
52dendrite morphogenesis (GO:0048813)3.35283737
53amino acid import (GO:0043090)3.34734811
54response to auditory stimulus (GO:0010996)3.33721068
55regulation of synaptic plasticity (GO:0048167)3.33578435
56cerebellar Purkinje cell differentiation (GO:0021702)3.30681599
57auditory behavior (GO:0031223)3.28404224
58regulation of neurotransmitter secretion (GO:0046928)3.27856061
59vesicle transport along microtubule (GO:0047496)3.26971518
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26114065
61regulation of dendritic spine morphogenesis (GO:0061001)3.23202122
62regulation of neurotransmitter levels (GO:0001505)3.22089583
63regulation of postsynaptic membrane potential (GO:0060078)3.21574120
64mitochondrion transport along microtubule (GO:0047497)3.21311312
65establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.21311312
66presynaptic membrane organization (GO:0097090)3.19583835
67membrane depolarization during action potential (GO:0086010)3.18357685
68prepulse inhibition (GO:0060134)3.18219535
69axon ensheathment in central nervous system (GO:0032291)3.17383902
70central nervous system myelination (GO:0022010)3.17383902
71neuronal ion channel clustering (GO:0045161)3.17148361
72regulation of synapse maturation (GO:0090128)3.16772514
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.15444813
74L-amino acid import (GO:0043092)3.15364481
75transmission of nerve impulse (GO:0019226)3.13101208
76positive regulation of synapse maturation (GO:0090129)3.08631224
77potassium ion import (GO:0010107)3.08490136
78mating behavior (GO:0007617)3.08248974
79neuron recognition (GO:0008038)3.05761574
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05266024
81presynaptic membrane assembly (GO:0097105)3.04338152
82cerebellar Purkinje cell layer development (GO:0021680)3.03806447
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03566446
84regulation of neurotransmitter transport (GO:0051588)3.02326012
85positive regulation of neurotransmitter secretion (GO:0001956)3.01797627
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00250302
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.99965988
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99272193
89positive regulation of neurotransmitter transport (GO:0051590)2.98935122
90regulation of voltage-gated calcium channel activity (GO:1901385)2.98834738
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98722970
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98281392
93alanine transport (GO:0032328)2.96921667
94pyrimidine nucleobase catabolic process (GO:0006208)2.93251175
95cellular sodium ion homeostasis (GO:0006883)2.92482964
96negative regulation of dendrite morphogenesis (GO:0050774)2.92303180
97membrane depolarization (GO:0051899)2.91829127
98regulation of vesicle fusion (GO:0031338)2.91013627
99neuromuscular process (GO:0050905)2.90990084
100long-term synaptic potentiation (GO:0060291)2.89413735
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89351878
102dendritic spine organization (GO:0097061)2.89073144
103axonal fasciculation (GO:0007413)2.88690542
104organelle transport along microtubule (GO:0072384)2.86397360
105cell migration in hindbrain (GO:0021535)2.86285317
106adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.84745674
107intraspecies interaction between organisms (GO:0051703)2.84703470
108social behavior (GO:0035176)2.84703470
109neuromuscular synaptic transmission (GO:0007274)2.83544758
110axon extension (GO:0048675)2.82300508
111axon cargo transport (GO:0008088)2.81982129
112positive regulation of synaptic transmission (GO:0050806)2.81652936
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.81337373
114membrane hyperpolarization (GO:0060081)2.79801926
115regulation of synaptic transmission (GO:0050804)2.78453766
116innervation (GO:0060384)2.77204120
117cell differentiation in hindbrain (GO:0021533)2.77119387
118regulation of clathrin-mediated endocytosis (GO:2000369)2.76273255
119potassium ion homeostasis (GO:0055075)2.76221608
120postsynaptic membrane organization (GO:0001941)2.75949193
121dopamine receptor signaling pathway (GO:0007212)2.75901697
122positive regulation of dendritic spine development (GO:0060999)2.74949212
123learning (GO:0007612)2.74126268
124regulation of dendritic spine development (GO:0060998)2.72928928
125chemosensory behavior (GO:0007635)2.72205079
126cell communication involved in cardiac conduction (GO:0086065)2.69769955
127cellular response to monoamine stimulus (GO:0071868)2.66347653
128cellular response to catecholamine stimulus (GO:0071870)2.66347653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36674949
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83346087
3DROSHA_22980978_ChIP-Seq_HELA_Human2.78508938
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77500820
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73438983
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.68940627
7REST_21632747_ChIP-Seq_MESCs_Mouse2.67366265
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59169799
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59169799
10GBX2_23144817_ChIP-Seq_PC3_Human2.58294630
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50564478
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46929361
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46318602
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38917583
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33455594
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31616311
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27918039
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27321438
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23724221
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.21341868
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.19573422
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.18145740
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17982947
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.11402338
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.94309077
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92736578
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80941159
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75463817
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75045994
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.69194158
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.64617668
32AR_21572438_ChIP-Seq_LNCaP_Human1.57946493
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56603297
34KDM2B_26808549_Chip-Seq_K562_Human1.53632270
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53147285
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46530270
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45895449
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.41645844
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41292521
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39803372
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36711926
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36013436
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34850775
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31973266
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.31545381
46* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29948586
47SMAD4_21799915_ChIP-Seq_A2780_Human1.29144169
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.28570021
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27248707
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.25790881
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25467900
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21912007
53AR_19668381_ChIP-Seq_PC3_Human1.20366129
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.19234171
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17814213
56ZNF274_21170338_ChIP-Seq_K562_Hela1.15312715
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15241922
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15147317
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14800038
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12910529
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12336189
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12072483
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11764034
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11587519
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.11288119
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09590497
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08563761
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07787157
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07172502
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.06531013
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05518188
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04781375
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03965807
74STAT3_23295773_ChIP-Seq_U87_Human1.03930096
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03574369
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.02718856
77CREB1_26743006_Chip-Seq_LNCaP_Human1.02677685
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02186921
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01279835
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99874096
81AR_25329375_ChIP-Seq_VCAP_Human0.98966518
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98343721
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97506105
84CTCF_27219007_Chip-Seq_Bcells_Human0.96694659
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96587248
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.96390844
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96150812
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95242728
89SMAD3_21741376_ChIP-Seq_EPCs_Human0.94366870
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.93951176
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93549267
92RXR_22108803_ChIP-Seq_LS180_Human0.93230539
93TP53_23651856_ChIP-Seq_MEFs_Mouse0.92890545
94AHR_22903824_ChIP-Seq_MCF-7_Human0.92621742
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.91675318
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.91659653
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91424619
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91013229
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90853196
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90535266
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89961962
102LXR_22292898_ChIP-Seq_THP-1_Human0.89908241
103P68_20966046_ChIP-Seq_HELA_Human0.89733205
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88621357
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88601323
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88527706
107TCF4_23295773_ChIP-Seq_U87_Human0.88236113
108KLF4_19829295_ChIP-Seq_ESCs_Human0.88223157
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.87587082
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.87078535
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.86559442
112RACK7_27058665_Chip-Seq_MCF-7_Human0.85762669
113KDM2B_26808549_Chip-Seq_DND41_Human0.85003387
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84995659
115TCF7_22412390_ChIP-Seq_EML_Mouse0.84685687
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84443973
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.84394423
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.83629372
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.82815129
120RNF2_27304074_Chip-Seq_NSC_Mouse0.82492644
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82134700
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82067957
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81473985
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80746015
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.80522108
126SMC4_20622854_ChIP-Seq_HELA_Human0.80494895
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80244156
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78806559
129P300_19829295_ChIP-Seq_ESCs_Human0.78178375
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77788150
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77658180
132TP53_16413492_ChIP-PET_HCT116_Human0.77650455
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77221512
134OCT4_19829295_ChIP-Seq_ESCs_Human0.75725389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.05808451
2MP0003635_abnormal_synaptic_transmissio4.16756967
3MP0003880_abnormal_central_pattern3.99234369
4MP0004270_analgesia3.84117558
5MP0002063_abnormal_learning/memory/cond3.25917751
6MP0009745_abnormal_behavioral_response3.24843763
7MP0002064_seizures3.09953046
8MP0009046_muscle_twitch3.02049868
9MP0005423_abnormal_somatic_nervous3.00210206
10MP0001968_abnormal_touch/_nociception2.92773561
11MP0002734_abnormal_mechanical_nocicepti2.65681560
12MP0002572_abnormal_emotion/affect_behav2.60791587
13MP0002822_catalepsy2.59059418
14MP0001486_abnormal_startle_reflex2.49552941
15MP0004858_abnormal_nervous_system2.47610847
16MP0002272_abnormal_nervous_system2.39712716
17MP0009780_abnormal_chondrocyte_physiolo2.33716329
18MP0001501_abnormal_sleep_pattern2.24407576
19MP0002735_abnormal_chemical_nociception2.18741679
20MP0002909_abnormal_adrenal_gland2.18091356
21MP0002733_abnormal_thermal_nociception2.12824880
22MP0002736_abnormal_nociception_after2.12097378
23MP0008569_lethality_at_weaning2.02613352
24MP0001970_abnormal_pain_threshold2.01668705
25MP0003329_amyloid_beta_deposits2.00611425
26MP0001440_abnormal_grooming_behavior1.98783936
27MP0004811_abnormal_neuron_physiology1.97918694
28MP0002067_abnormal_sensory_capabilities1.81261237
29MP0000569_abnormal_digit_pigmentation1.75546257
30MP0004885_abnormal_endolymph1.68355533
31MP0002184_abnormal_innervation1.66222384
32MP0003879_abnormal_hair_cell1.65196348
33MP0000955_abnormal_spinal_cord1.64926307
34MP0003123_paternal_imprinting1.64555717
35MP0002557_abnormal_social/conspecific_i1.63873600
36MP0000778_abnormal_nervous_system1.62070404
37MP0004924_abnormal_behavior1.57582354
38MP0005386_behavior/neurological_phenoty1.57582354
39MP0005646_abnormal_pituitary_gland1.55515725
40MP0003633_abnormal_nervous_system1.53914327
41MP0005645_abnormal_hypothalamus_physiol1.46893565
42MP0002066_abnormal_motor_capabilities/c1.41355362
43MP0003172_abnormal_lysosome_physiology1.39027478
44MP0008961_abnormal_basal_metabolism1.37657451
45MP0002882_abnormal_neuron_morphology1.37536293
46MP0003075_altered_response_to1.37374899
47MP0005257_abnormal_intraocular_pressure1.37178089
48MP0003283_abnormal_digestive_organ1.34509315
49MP0005409_darkened_coat_color1.28832901
50MP0003690_abnormal_glial_cell1.27079119
51MP0003787_abnormal_imprinting1.27006426
52MP0006276_abnormal_autonomic_nervous1.24871668
53MP0001502_abnormal_circadian_rhythm1.24684502
54MP0003631_nervous_system_phenotype1.22933196
55MP0005167_abnormal_blood-brain_barrier1.20871766
56MP0001984_abnormal_olfaction1.15453376
57MP0000751_myopathy1.12655629
58MP0000604_amyloidosis1.09492251
59MP0003634_abnormal_glial_cell1.08353826
60MP0003705_abnormal_hypodermis_morpholog1.08314643
61MP0004145_abnormal_muscle_electrophysio1.06746684
62MP0000920_abnormal_myelination1.03329981
63MP0002152_abnormal_brain_morphology1.02890750
64MP0004510_myositis1.01087113
65MP0000013_abnormal_adipose_tissue1.00186231
66MP0002229_neurodegeneration0.97918947
67MP0004142_abnormal_muscle_tone0.97129324
68MP0008874_decreased_physiological_sensi0.94603228
69MP0001188_hyperpigmentation0.94011874
70MP0002069_abnormal_eating/drinking_beha0.93142963
71MP0005535_abnormal_body_temperature0.90867000
72MP0001177_atelectasis0.89635711
73MP0003122_maternal_imprinting0.88501048
74MP0003121_genomic_imprinting0.86443698
75MP0003632_abnormal_nervous_system0.85744197
76MP0002653_abnormal_ependyma_morphology0.85296343
77MP0005499_abnormal_olfactory_system0.85072493
78MP0004130_abnormal_muscle_cell0.83439089
79MP0005623_abnormal_meninges_morphology0.82983978
80MP0004085_abnormal_heartbeat0.82712817
81MP0010386_abnormal_urinary_bladder0.82358733
82MP0008872_abnormal_physiological_respon0.81229481
83MP0003861_abnormal_nervous_system0.80886539
84MP0000579_abnormal_nail_morphology0.80835091
85MP0002090_abnormal_vision0.79141274
86MP0004742_abnormal_vestibular_system0.78132969
87MP0002249_abnormal_larynx_morphology0.77422133
88MP0001905_abnormal_dopamine_level0.76064295
89MP0000534_abnormal_ureter_morphology0.75459493
90MP0001958_emphysema0.75048997
91MP0001299_abnormal_eye_distance/0.73025604
92MP0004233_abnormal_muscle_weight0.72071437
93MP0001943_abnormal_respiration0.69412047
94MP0003303_peritoneal_inflammation0.68207946
95MP0000747_muscle_weakness0.68033473
96MP0000003_abnormal_adipose_tissue0.66074846
97MP0001849_ear_inflammation0.65025701
98MP0005166_decreased_susceptibility_to0.61262129
99MP0003045_fibrosis0.61224202
100MP0003137_abnormal_impulse_conducting0.61103989
101MP0002082_postnatal_lethality0.60551616
102MP0010770_preweaning_lethality0.60551616
103MP0001963_abnormal_hearing_physiology0.58955452
104MP0010768_mortality/aging0.58814632
105MP0002081_perinatal_lethality0.58721683
106MP0004043_abnormal_pH_regulation0.58212994
107MP0003646_muscle_fatigue0.57931806
108MP0003183_abnormal_peptide_metabolism0.57608799
109MP0005551_abnormal_eye_electrophysiolog0.57369974
110MP0002752_abnormal_somatic_nervous0.57055746
111MP0000566_synostosis0.56700204
112MP0000537_abnormal_urethra_morphology0.56639470
113MP0004484_altered_response_of0.55921007
114MP0001529_abnormal_vocalization0.54606353
115MP0000026_abnormal_inner_ear0.54348777
116MP0004215_abnormal_myocardial_fiber0.53853339
117MP0001348_abnormal_lacrimal_gland0.53564384
118MP0002089_abnormal_postnatal_growth/wei0.52474080
119MP0000631_abnormal_neuroendocrine_gland0.50513767
120MP0010769_abnormal_survival0.50403662
121MP0002638_abnormal_pupillary_reflex0.49020212
122MP0002837_dystrophic_cardiac_calcinosis0.48847063
123MP0005394_taste/olfaction_phenotype0.48551916

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.82509227
2Focal motor seizures (HP:0011153)6.30317199
3Focal seizures (HP:0007359)5.20326351
4Visual hallucinations (HP:0002367)5.18960929
5Supranuclear gaze palsy (HP:0000605)4.41567008
6Action tremor (HP:0002345)4.24788953
7Ankle clonus (HP:0011448)4.00713142
8Progressive cerebellar ataxia (HP:0002073)3.89938925
9Epileptic encephalopathy (HP:0200134)3.84763881
10Febrile seizures (HP:0002373)3.68184566
11Mutism (HP:0002300)3.62241490
12Atonic seizures (HP:0010819)3.61241709
13Papilledema (HP:0001085)3.55858217
14Generalized tonic-clonic seizures (HP:0002069)3.50178762
15Absence seizures (HP:0002121)3.43412128
16Depression (HP:0000716)3.36151734
17Poor eye contact (HP:0000817)3.30140828
18Postural instability (HP:0002172)3.26223410
19Urinary bladder sphincter dysfunction (HP:0002839)3.24544393
20Impaired vibration sensation in the lower limbs (HP:0002166)3.19938207
21Abnormality of the lower motor neuron (HP:0002366)3.13834703
22Dialeptic seizures (HP:0011146)3.12657204
23Impaired social interactions (HP:0000735)3.08046505
24Abnormal social behavior (HP:0012433)3.08046505
25Abnormal eating behavior (HP:0100738)2.95386934
26Torticollis (HP:0000473)2.86645590
27Dysmetria (HP:0001310)2.84606483
28Anxiety (HP:0000739)2.82762185
29Urinary urgency (HP:0000012)2.81945362
30Broad-based gait (HP:0002136)2.81891811
31Dysdiadochokinesis (HP:0002075)2.81584528
32Genetic anticipation (HP:0003743)2.80992346
33Neurofibrillary tangles (HP:0002185)2.78817968
34Gaze-evoked nystagmus (HP:0000640)2.77008400
35Ventricular fibrillation (HP:0001663)2.75618067
36Hemiplegia (HP:0002301)2.73830155
37Truncal ataxia (HP:0002078)2.71921127
38Insomnia (HP:0100785)2.69916707
39Spastic gait (HP:0002064)2.62032387
40Tetraplegia (HP:0002445)2.59635086
41Intention tremor (HP:0002080)2.58910766
42Peripheral hypomyelination (HP:0007182)2.58731734
43Cerebral inclusion bodies (HP:0100314)2.57309348
44Sleep apnea (HP:0010535)2.56925926
45Megalencephaly (HP:0001355)2.54403092
46Focal dystonia (HP:0004373)2.52723293
47Bundle branch block (HP:0011710)2.50080974
48Abnormality of binocular vision (HP:0011514)2.49568871
49Diplopia (HP:0000651)2.49568871
50Turricephaly (HP:0000262)2.47395128
51Hemiparesis (HP:0001269)2.46130987
52Impaired smooth pursuit (HP:0007772)2.43525162
53Stereotypic behavior (HP:0000733)2.41939559
54Akinesia (HP:0002304)2.41704031
55Progressive inability to walk (HP:0002505)2.39424661
56Pointed chin (HP:0000307)2.38879105
57Bradykinesia (HP:0002067)2.38001527
58Lower limb muscle weakness (HP:0007340)2.37416351
59Shallow orbits (HP:0000586)2.37262154
60Annular pancreas (HP:0001734)2.36221524
61Termporal pattern (HP:0011008)2.34313114
62Insidious onset (HP:0003587)2.34313114
63Neuronal loss in central nervous system (HP:0002529)2.32487579
64Amblyopia (HP:0000646)2.31204186
65Upper limb amyotrophy (HP:0009129)2.27955451
66Distal upper limb amyotrophy (HP:0007149)2.27955451
67Craniofacial dystonia (HP:0012179)2.27924181
68Drooling (HP:0002307)2.26682636
69Excessive salivation (HP:0003781)2.26682636
70Agitation (HP:0000713)2.23129357
71Hypoventilation (HP:0002791)2.21771124
72Abnormality of ocular smooth pursuit (HP:0000617)2.19531080
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19311409
74Apathy (HP:0000741)2.18218234
75Dysmetric saccades (HP:0000641)2.18168180
76Hand muscle atrophy (HP:0009130)2.17709504
77Lower limb amyotrophy (HP:0007210)2.17670580
78Difficulty running (HP:0009046)2.16350186
79Obstructive sleep apnea (HP:0002870)2.16334658
80Clonus (HP:0002169)2.16076753
81Rapidly progressive (HP:0003678)2.12855395
82Abnormality of the corticospinal tract (HP:0002492)2.12240656
83Status epilepticus (HP:0002133)2.09469540
84Impaired vibratory sensation (HP:0002495)2.09259828
85Hyperacusis (HP:0010780)2.06982187
86Pheochromocytoma (HP:0002666)2.06666919
87Fetal akinesia sequence (HP:0001989)2.03926743
88Hyperparathyroidism (HP:0000843)2.02982777
89Hammertoe (HP:0001765)2.01941306
90Inappropriate behavior (HP:0000719)2.00940275
91Scanning speech (HP:0002168)2.00028273
92Amyotrophic lateral sclerosis (HP:0007354)1.98116766
93EEG with generalized epileptiform discharges (HP:0011198)1.94479409
94Limb dystonia (HP:0002451)1.94208385
95Epileptiform EEG discharges (HP:0011182)1.93300360
96Aplasia involving bones of the extremities (HP:0009825)1.93142619
97Aplasia involving bones of the upper limbs (HP:0009823)1.93142619
98Aplasia of the phalanges of the hand (HP:0009802)1.93142619
99Abnormality of saccadic eye movements (HP:0000570)1.92901357
100Abnormal EKG (HP:0003115)1.92150312
101Hypsarrhythmia (HP:0002521)1.91943339
102Bronchomalacia (HP:0002780)1.91372159
103Rigidity (HP:0002063)1.90932758
104Diminished motivation (HP:0000745)1.90582381
105Abnormality of the periventricular white matter (HP:0002518)1.90143554
106Foot dorsiflexor weakness (HP:0009027)1.90131147
107Cerebral aneurysm (HP:0004944)1.87772005
108Hypercortisolism (HP:0001578)1.87194017
109Overriding aorta (HP:0002623)1.87053291
110Polyphagia (HP:0002591)1.86581850
111Spastic tetraparesis (HP:0001285)1.85542576
112Absent speech (HP:0001344)1.84321955
113Elfin facies (HP:0004428)1.83632906
114Resting tremor (HP:0002322)1.80895973
115Anosmia (HP:0000458)1.80801618
116Gait ataxia (HP:0002066)1.80424160
117Hyperventilation (HP:0002883)1.79853190
118Generalized myoclonic seizures (HP:0002123)1.79297397
119Difficulty climbing stairs (HP:0003551)1.79176684
120Spinal canal stenosis (HP:0003416)1.78122427
121Incomplete penetrance (HP:0003829)1.74148752
122Abnormality of the foot musculature (HP:0001436)1.74009570
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71238133
124Mitral regurgitation (HP:0001653)1.70663529
125Cerebral hypomyelination (HP:0006808)1.68796040
126Hypoplasia of the corpus callosum (HP:0002079)1.67117655
127Achilles tendon contracture (HP:0001771)1.66688378
128Hyperthyroidism (HP:0000836)1.65740238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.16238644
2NTRK34.05272134
3EPHA43.60441779
4MARK13.30061717
5PRKD32.91144199
6DAPK22.70244086
7MINK12.64724695
8PAK62.61352046
9MAP3K42.55639287
10CASK2.40549443
11KSR22.40203497
12CAMKK12.32857226
13NTRK12.18651323
14NTRK22.15518565
15MAP2K71.91898039
16RIPK41.77587757
17STK381.75349831
18SIK21.74910701
19MAP2K41.68538197
20CDK51.57048795
21TAOK11.47642531
22MAP3K21.39708748
23PHKG11.36825879
24PHKG21.36825879
25KSR11.34184914
26LATS21.27557133
27TYRO31.26248565
28PRKCH1.22913604
29DAPK11.22634269
30MAP3K131.18919667
31RIPK11.18288112
32ALK1.18209834
33GRK51.18198042
34UHMK11.17323886
35FES1.16835246
36MAP3K121.15934808
37TESK11.14350779
38CAMKK21.13895658
39RET1.12293739
40LMTK21.11510655
41PLK21.07909175
42PRKCG1.05363905
43MAPK131.00155996
44STK110.99933471
45CAMK10.98415428
46CDK190.97446117
47PRPF4B0.95570890
48LIMK10.93996993
49MAP3K110.93700238
50MARK20.93429782
51EPHB20.93204627
52PINK10.92936687
53ARAF0.91637326
54TNIK0.90332372
55CAMK1G0.89820472
56SGK2230.87370882
57SGK4940.87370882
58TRIB30.84958537
59CDK150.82770814
60SGK30.82767384
61MAP3K10.82137102
62CDK180.81605771
63PDK10.80960683
64PDPK10.79136451
65CDK140.78037447
66SCYL20.77967388
67PAK30.74654005
68PTK20.73869496
69ROCK20.72652149
70TAOK30.72454880
71CDK11A0.71742609
72PKN10.71561452
73WNK10.71530625
74CAMK2G0.71375185
75CDC42BPA0.69173697
76CAMK2A0.67487949
77SIK10.66862519
78MOS0.66555374
79DYRK1B0.66510902
80PNCK0.65483981
81EEF2K0.64926273
82SGK10.64713776
83SGK20.64110975
84TNK20.63873771
85DYRK20.63531332
86TTN0.58906637
87PTK2B0.57775780
88NEK10.57456311
89EPHA30.56507373
90MAP3K70.55884081
91PRKCZ0.55517499
92DMPK0.54350949
93EPHB10.54218003
94FYN0.54082030
95CSNK1G20.52114768
96ICK0.51959519
97RPS6KA30.51584870
98RAF10.50937903
99CAMK40.49870023
100MAPK100.49638676
101PDGFRA0.49028260
102CAMK2D0.46939782
103DYRK1A0.46923988
104BRSK10.46740778
105BRAF0.46625849
106RPS6KA20.46442105
107PRKD20.46383179
108ROCK10.42379253
109MAP3K60.42239593
110FGFR20.40233553
111CAMK2B0.39588984
112DAPK30.39202306
113MTOR0.38989252
114BMX0.37713115
115PRKCE0.35352680
116MAP2K10.34190162
117NEK60.34032459
118ERBB30.33814467
119SIK30.32747455
120OXSR10.31334304
121FER0.31297681
122DDR20.30916549
123BMPR20.30480484
124CAMK1D0.28762819
125MAPK120.28462966

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.14736923
2Nicotine addiction_Homo sapiens_hsa050332.78739377
3Olfactory transduction_Homo sapiens_hsa047402.62954493
4Circadian entrainment_Homo sapiens_hsa047132.42498671
5GABAergic synapse_Homo sapiens_hsa047272.41086383
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33865586
7Long-term potentiation_Homo sapiens_hsa047202.30725449
8Glutamatergic synapse_Homo sapiens_hsa047242.25754471
9Morphine addiction_Homo sapiens_hsa050322.20049782
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16372421
11Amphetamine addiction_Homo sapiens_hsa050312.03062664
12Insulin secretion_Homo sapiens_hsa049111.98155254
13Salivary secretion_Homo sapiens_hsa049701.94801359
14Dopaminergic synapse_Homo sapiens_hsa047281.89914251
15Cholinergic synapse_Homo sapiens_hsa047251.85153291
16Gastric acid secretion_Homo sapiens_hsa049711.83498494
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76380591
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68036738
19Nitrogen metabolism_Homo sapiens_hsa009101.67373954
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57832440
21Oxytocin signaling pathway_Homo sapiens_hsa049211.54099331
22Type II diabetes mellitus_Homo sapiens_hsa049301.52215900
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50710527
24Cocaine addiction_Homo sapiens_hsa050301.50283980
25Renin secretion_Homo sapiens_hsa049241.47474044
26GnRH signaling pathway_Homo sapiens_hsa049121.41579893
27Long-term depression_Homo sapiens_hsa047301.40929062
28Calcium signaling pathway_Homo sapiens_hsa040201.36575053
29Taste transduction_Homo sapiens_hsa047421.35293409
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28896266
31Serotonergic synapse_Homo sapiens_hsa047261.27576884
32Glioma_Homo sapiens_hsa052141.27254211
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26320295
34Gap junction_Homo sapiens_hsa045401.26090077
35Estrogen signaling pathway_Homo sapiens_hsa049151.22505108
36cAMP signaling pathway_Homo sapiens_hsa040241.21700056
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17316378
38Dorso-ventral axis formation_Homo sapiens_hsa043201.10656211
39ErbB signaling pathway_Homo sapiens_hsa040121.06716091
40Axon guidance_Homo sapiens_hsa043601.04063095
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02423353
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98829985
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.98265160
44Collecting duct acid secretion_Homo sapiens_hsa049660.97853531
45Melanogenesis_Homo sapiens_hsa049160.94935552
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94398871
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93279622
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91590563
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.89955235
50Vitamin B6 metabolism_Homo sapiens_hsa007500.86608976
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.85106643
52Dilated cardiomyopathy_Homo sapiens_hsa054140.82747078
53Pancreatic secretion_Homo sapiens_hsa049720.81907544
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80177678
55VEGF signaling pathway_Homo sapiens_hsa043700.78885482
56mTOR signaling pathway_Homo sapiens_hsa041500.77821932
57Notch signaling pathway_Homo sapiens_hsa043300.77167505
58Thyroid hormone synthesis_Homo sapiens_hsa049180.75735708
59Choline metabolism in cancer_Homo sapiens_hsa052310.74391912
60MAPK signaling pathway_Homo sapiens_hsa040100.73792699
61Endocytosis_Homo sapiens_hsa041440.73397855
62Oocyte meiosis_Homo sapiens_hsa041140.71118914
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69444192
64Type I diabetes mellitus_Homo sapiens_hsa049400.66690439
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.66140214
66Vibrio cholerae infection_Homo sapiens_hsa051100.65746683
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64971562
68Endometrial cancer_Homo sapiens_hsa052130.64736373
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64516740
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64382653
71Renal cell carcinoma_Homo sapiens_hsa052110.63356857
72Bile secretion_Homo sapiens_hsa049760.61867270
73Rap1 signaling pathway_Homo sapiens_hsa040150.61640201
74AMPK signaling pathway_Homo sapiens_hsa041520.61529534
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61369913
76Focal adhesion_Homo sapiens_hsa045100.60757588
77Non-small cell lung cancer_Homo sapiens_hsa052230.59784752
78Insulin signaling pathway_Homo sapiens_hsa049100.59770707
79Glucagon signaling pathway_Homo sapiens_hsa049220.59690340
80Ras signaling pathway_Homo sapiens_hsa040140.59594621
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59257149
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58838428
83Prion diseases_Homo sapiens_hsa050200.58471458
84Cardiac muscle contraction_Homo sapiens_hsa042600.58334363
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57574529
86Chemokine signaling pathway_Homo sapiens_hsa040620.56881883
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54077690
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54047634
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53076830
90Inositol phosphate metabolism_Homo sapiens_hsa005620.52398421
91Hippo signaling pathway_Homo sapiens_hsa043900.51454081
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49657080
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47310808
94Prolactin signaling pathway_Homo sapiens_hsa049170.47184118
95Wnt signaling pathway_Homo sapiens_hsa043100.47025292
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46105488
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44494283
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43591165
99Amoebiasis_Homo sapiens_hsa051460.43551016
100Chronic myeloid leukemia_Homo sapiens_hsa052200.43377336
101Phototransduction_Homo sapiens_hsa047440.42372504
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41676003
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40902560
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40677435
105Tight junction_Homo sapiens_hsa045300.40268268
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39153815
107Platelet activation_Homo sapiens_hsa046110.38028116
108Ovarian steroidogenesis_Homo sapiens_hsa049130.37496779
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37383422
110Circadian rhythm_Homo sapiens_hsa047100.36451774
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35810846
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35618332
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.35475996

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