FAM219B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.57600163
2regulation of nuclear cell cycle DNA replication (GO:0033262)6.38740195
3pyrimidine nucleobase catabolic process (GO:0006208)6.20736090
4regulation of mammary gland epithelial cell proliferation (GO:0033599)5.76522978
5somite rostral/caudal axis specification (GO:0032525)5.41060856
6negative regulation of epidermis development (GO:0045683)5.06449738
7maintenance of protein location in nucleus (GO:0051457)4.96801261
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.94464108
9rRNA transcription (GO:0009303)4.85082514
10nucleobase catabolic process (GO:0046113)4.79675773
11establishment of mitochondrion localization (GO:0051654)4.61411746
12negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.60048539
13negative regulation of cell cycle G2/M phase transition (GO:1902750)4.59964219
14regulation of telomere maintenance via telomerase (GO:0032210)4.55057719
15rRNA methylation (GO:0031167)4.52406859
16histone H4-K8 acetylation (GO:0043982)4.50942244
17histone H4-K5 acetylation (GO:0043981)4.50942244
18histone H4-K12 acetylation (GO:0043983)4.49441241
19nucleoside transmembrane transport (GO:1901642)4.39971915
20cytidine metabolic process (GO:0046087)4.37526516
21cytidine catabolic process (GO:0006216)4.37526516
22cytidine deamination (GO:0009972)4.37526516
23neuronal ion channel clustering (GO:0045161)4.28787509
24regulation of response to osmotic stress (GO:0047484)4.26537944
25negative regulation of telomere maintenance (GO:0032205)4.23198612
26regulation of MHC class I biosynthetic process (GO:0045343)4.22346867
27positive regulation of DNA-dependent DNA replication (GO:2000105)4.20710650
28dendritic spine morphogenesis (GO:0060997)4.17985533
29DNA replication checkpoint (GO:0000076)4.13415377
30interferon-gamma production (GO:0032609)4.08792733
31negative regulation of telomerase activity (GO:0051974)4.06701282
32negative regulation of epidermal cell differentiation (GO:0045605)4.06451231
33quinone metabolic process (GO:1901661)4.06382628
34regulation of short-term neuronal synaptic plasticity (GO:0048172)4.05378475
35axonal fasciculation (GO:0007413)4.04929679
36regulation of cilium movement (GO:0003352)4.02054558
37rRNA modification (GO:0000154)4.01066131
38regulation of apoptotic process involved in morphogenesis (GO:1902337)4.00721053
39regulation of synapse structural plasticity (GO:0051823)3.99205902
40establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.95382719
41mitochondrion transport along microtubule (GO:0047497)3.95382719
42GDP-mannose metabolic process (GO:0019673)3.87014825
43definitive hemopoiesis (GO:0060216)3.83941710
44notochord development (GO:0030903)3.79661589
45cyclooxygenase pathway (GO:0019371)3.78590873
46nonmotile primary cilium assembly (GO:0035058)3.72912991
47postsynaptic membrane organization (GO:0001941)3.67910131
48neuron cell-cell adhesion (GO:0007158)3.61330922
49protein localization to kinetochore (GO:0034501)3.60761683
50neuron recognition (GO:0008038)3.57745856
51presynaptic membrane assembly (GO:0097105)3.52698571
52omega-hydroxylase P450 pathway (GO:0097267)3.50530153
53negative regulation of phagocytosis (GO:0050765)3.46944790
54presynaptic membrane organization (GO:0097090)3.46093074
55regulation of translation in response to stress (GO:0043555)3.45158642
56epithelial cilium movement (GO:0003351)3.43884078
57mitotic sister chromatid segregation (GO:0000070)3.42758409
58neuronal action potential propagation (GO:0019227)3.42062909
59neurotransmitter-gated ion channel clustering (GO:0072578)3.41137307
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40108792
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.38405677
62muscle organ morphogenesis (GO:0048644)3.38403215
63response to dietary excess (GO:0002021)3.37076216
64negative regulation of systemic arterial blood pressure (GO:0003085)3.35008617
65nucleoside transport (GO:0015858)3.34553771
66mitochondrion distribution (GO:0048311)3.33902200
67cullin deneddylation (GO:0010388)3.33123038
68axoneme assembly (GO:0035082)3.33120882
69pyrimidine ribonucleoside catabolic process (GO:0046133)3.31512125
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31139594
71vocalization behavior (GO:0071625)3.30359323
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29839807
73ventricular trabecula myocardium morphogenesis (GO:0003222)3.29596233
74receptor recycling (GO:0001881)3.29539369
75detection of temperature stimulus (GO:0016048)3.28117253
76cell migration in hindbrain (GO:0021535)3.27828850
77phagocytosis, recognition (GO:0006910)3.26975393
78protein deneddylation (GO:0000338)3.25225812
79regulation of telomere maintenance (GO:0032204)3.23068309
80negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.22855238
81calcium-mediated signaling using intracellular calcium source (GO:0035584)3.21472594
82cilium movement (GO:0003341)3.20407391
83phenol-containing compound catabolic process (GO:0019336)3.16626783
84positive regulation of defense response to virus by host (GO:0002230)3.15641010
85tachykinin receptor signaling pathway (GO:0007217)3.15515842
86layer formation in cerebral cortex (GO:0021819)3.14155461
87negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.13507704
88synaptic vesicle exocytosis (GO:0016079)3.13278953
89retinal ganglion cell axon guidance (GO:0031290)3.13148102
90regulation of telomerase activity (GO:0051972)3.13126709
91synaptic vesicle maturation (GO:0016188)3.11810235
92intraciliary transport (GO:0042073)3.11739330
93DNA damage response, detection of DNA damage (GO:0042769)3.10961068
94coenzyme catabolic process (GO:0009109)3.10827693
95ventricular system development (GO:0021591)3.09733150
96regulation of pigment cell differentiation (GO:0050932)3.08858982
97synaptic vesicle docking involved in exocytosis (GO:0016081)3.08136041
98positive regulation of mitochondrial fission (GO:0090141)3.07086164
99protein localization to synapse (GO:0035418)3.06851273
100regulation of G0 to G1 transition (GO:0070316)3.05994376
101glycosphingolipid biosynthetic process (GO:0006688)3.05472684
102dendritic spine organization (GO:0097061)3.04320766
103positive regulation of amino acid transport (GO:0051957)3.03544735
104regulation of synaptic vesicle exocytosis (GO:2000300)3.02208004
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.97426325
106axon extension involved in axon guidance (GO:0048846)2.97426325
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97134671
108cilium morphogenesis (GO:0060271)2.94998306
109activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.93387386
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.91940598
111histone H4-K16 acetylation (GO:0043984)2.91861863
112intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.91688512
113primitive streak formation (GO:0090009)2.90908273
114transmission of nerve impulse (GO:0019226)2.90784128
115regulation of double-strand break repair (GO:2000779)2.90209883
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.88609483
117hormone catabolic process (GO:0042447)2.88277845
118positive regulation of dendritic spine development (GO:0060999)2.86453150
119epithelial cell differentiation involved in kidney development (GO:0035850)2.86314901
120neurofilament cytoskeleton organization (GO:0060052)2.84988974
121behavioral response to ethanol (GO:0048149)2.84516151
122regulation of microtubule-based movement (GO:0060632)2.83667809
123negative regulation of signal transduction by p53 class mediator (GO:1901797)2.82177350
124ubiquinone metabolic process (GO:0006743)2.81406745
125fat-soluble vitamin biosynthetic process (GO:0042362)2.81227186
126branching involved in mammary gland duct morphogenesis (GO:0060444)2.80324203
127regulation of synaptic vesicle transport (GO:1902803)2.79834584
128negative regulation of interleukin-2 production (GO:0032703)2.79162192
129regulation of cardiac muscle cell apoptotic process (GO:0010665)2.78845528
130locomotory exploration behavior (GO:0035641)2.78031237
131ribosome biogenesis (GO:0042254)2.76586796
132negative regulation of bone resorption (GO:0045779)2.76052935
133pore complex assembly (GO:0046931)2.75969118
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74360616
135positive regulation of protein deacetylation (GO:0090312)2.74157123
136protein localization to chromosome, centromeric region (GO:0071459)2.73146407
137protein polyglutamylation (GO:0018095)2.72714329
138pseudouridine synthesis (GO:0001522)2.72439279
139epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71876677
140ubiquinone biosynthetic process (GO:0006744)2.71564597
141membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70783334
142synapse assembly (GO:0007416)2.70767500
143phosphatidylglycerol biosynthetic process (GO:0006655)2.70726430
144cornea development in camera-type eye (GO:0061303)2.70634668
145auditory behavior (GO:0031223)2.68872790
146negative regulation of axon guidance (GO:1902668)2.68867320
147axon extension (GO:0048675)2.67879666
148sister chromatid segregation (GO:0000819)2.67307161
149positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.67278003
150mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.67278003
151maintenance of protein localization in organelle (GO:0072595)2.67088086
152positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67021455
153synaptic transmission, glutamatergic (GO:0035249)2.66116731
154negative regulation of axonogenesis (GO:0050771)2.65133290
155aggressive behavior (GO:0002118)2.64891749
156sympathetic nervous system development (GO:0048485)2.63318868
157cardiac ventricle formation (GO:0003211)2.63122600
158regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.62682855
159nuclear pore complex assembly (GO:0051292)2.62489369
160cardiovascular system development (GO:0072358)2.62392533
161regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62261512
162DNA strand renaturation (GO:0000733)2.61203371
163regulation of Rac GTPase activity (GO:0032314)2.61154764
164cofactor transport (GO:0051181)2.60424073
165cell fate commitment involved in formation of primary germ layer (GO:0060795)2.59754106
166mammary gland development (GO:0030879)2.59721631
167brain morphogenesis (GO:0048854)2.59523883
168ionotropic glutamate receptor signaling pathway (GO:0035235)2.58645417
169dendrite morphogenesis (GO:0048813)2.58242705
170positive regulation of dendrite morphogenesis (GO:0050775)2.58207582
171spinal cord development (GO:0021510)2.56794901
172central nervous system projection neuron axonogenesis (GO:0021952)2.56297046
173positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55973744
174regulation of glutamate receptor signaling pathway (GO:1900449)2.55839706
175positive regulation of odontogenesis (GO:0042482)2.55715833
176neurotransmitter catabolic process (GO:0042135)2.54025352
177regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.53550361
178bone trabecula formation (GO:0060346)2.50759245
179positive regulation of synapse maturation (GO:0090129)2.50616546
180short-term memory (GO:0007614)2.50583059
181regulation of dendritic spine morphogenesis (GO:0061001)2.47796928
182synaptic vesicle endocytosis (GO:0048488)2.46837579
183regulation of glycogen (starch) synthase activity (GO:2000465)2.46517827
184microtubule bundle formation (GO:0001578)2.45594113
185cilium or flagellum-dependent cell motility (GO:0001539)2.45177448
186cardiac chamber formation (GO:0003207)2.45136295
187acidic amino acid transport (GO:0015800)2.43125544
188hippocampus development (GO:0021766)2.42843727
189cilium assembly (GO:0042384)2.41276751
190adult walking behavior (GO:0007628)2.40609019
191neuromuscular synaptic transmission (GO:0007274)2.39670427
192glutamate secretion (GO:0014047)2.38947862
193olfactory bulb development (GO:0021772)2.38733173
194axon ensheathment in central nervous system (GO:0032291)2.38491688
195central nervous system myelination (GO:0022010)2.38491688
196daunorubicin metabolic process (GO:0044597)10.6537308
197polyketide metabolic process (GO:0030638)10.6537308
198doxorubicin metabolic process (GO:0044598)10.6537308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.30295022
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.16637911
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.16637911
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.16637911
5E2F7_22180533_ChIP-Seq_HELA_Human6.08628268
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.02066602
7TP63_19390658_ChIP-ChIP_HaCaT_Human4.46346359
8EZH2_22144423_ChIP-Seq_EOC_Human4.15317446
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.87933493
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.52053988
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.51017014
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.07913286
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.84021167
14IRF1_19129219_ChIP-ChIP_H3396_Human2.62033857
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.39334684
16REST_21632747_ChIP-Seq_MESCs_Mouse2.39055834
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35485405
18ZNF274_21170338_ChIP-Seq_K562_Hela2.29319534
19GBX2_23144817_ChIP-Seq_PC3_Human2.25816786
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.23639355
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.19061028
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18178710
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.17514139
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17136711
25NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.16908397
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15930284
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14226826
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.14213291
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11764331
30DROSHA_22980978_ChIP-Seq_HELA_Human2.08174672
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.07515551
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06789892
33CBX2_27304074_Chip-Seq_ESCs_Mouse2.03975495
34RNF2_27304074_Chip-Seq_NSC_Mouse1.98553864
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.98083197
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.89973984
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.89289420
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.87663624
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87658530
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85629129
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85424140
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84935581
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82391192
44IGF1R_20145208_ChIP-Seq_DFB_Human1.79452390
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.79008048
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76738316
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76364325
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75294969
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75294969
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74065740
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72951497
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.72569036
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70713228
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68920727
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68097477
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66749603
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61649004
58SCL_19346495_ChIP-Seq_HPC-7_Human1.61166210
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61073075
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60096072
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58331975
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58011261
63TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.57038448
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54855179
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51672444
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51411459
67CTCF_27219007_Chip-Seq_Bcells_Human1.48932559
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.48148451
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46924838
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.44083007
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43538220
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42449038
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.42138938
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41209608
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.38250616
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36406872
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36063714
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34318225
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32624024
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32085038
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31214427
82E2F1_17053090_ChIP-ChIP_MCF-7_Human1.29367485
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.26432198
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25886551
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23756354
86PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.21889003
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21084544
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17691661
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17515283
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16963898
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.16472073
92MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16412412
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15913050
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15820206
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15156539
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14712151
97FUS_26573619_Chip-Seq_HEK293_Human1.14451244
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13646945
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.13589124
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12029289
101FOXP3_21729870_ChIP-Seq_TREG_Human1.11300179
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10809710
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09619221
104TAF15_26573619_Chip-Seq_HEK293_Human1.09112400
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08479233
106POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06268080
107NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05069173
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04984176
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04580241
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04580241
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.04536673
112CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03958791
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03843260
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03331485
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01823153
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01681271
117NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01575221
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98607924
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.98243073
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96499198
121STAT3_18555785_ChIP-Seq_MESCs_Mouse0.95948811
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95292657
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.94318112
124AR_19668381_ChIP-Seq_PC3_Human0.94149457
125P68_20966046_ChIP-Seq_HELA_Human0.93707317
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92640314
127SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92393067
128ELK1_19687146_ChIP-ChIP_HELA_Human0.92194159
129CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92107263
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92001142
131AR_21572438_ChIP-Seq_LNCaP_Human0.91959392
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.91743680
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.91463266
134MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91299547
135ERA_21632823_ChIP-Seq_H3396_Human0.90541863
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90506785
137WDR5_24793694_ChIP-Seq_LNCAP_Human0.90468474
138KDM2B_26808549_Chip-Seq_K562_Human0.88129741
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87940367
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86356983
141NANOG_16518401_ChIP-PET_MESCs_Mouse0.85979125
142OCT4_19829295_ChIP-Seq_ESCs_Human0.85414322
143POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85206167
144SMAD4_21799915_ChIP-Seq_A2780_Human0.84991800
145MYC_18555785_ChIP-Seq_MESCs_Mouse0.84947225
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84934012
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83992873
148SA1_27219007_Chip-Seq_ERYTHROID_Human0.83823185
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82652698
150SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82379578
151PHF8_20622854_ChIP-Seq_HELA_Human0.82032971
152POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82030876
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81316335
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81088707
155IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80705902
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80647306
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80599665
158SOX2_21211035_ChIP-Seq_LN229_Gbm0.80352070
159KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80320394
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79960555
161CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79911607
162NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79640479
163MYC_18940864_ChIP-ChIP_HL60_Human0.79619996
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78910840
165RING1B_27294783_Chip-Seq_NPCs_Mouse0.78718085
166CREB1_26743006_Chip-Seq_LNCaP_Human0.77715368
167FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77577877
168E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77487147
169SMC4_20622854_ChIP-Seq_HELA_Human0.76257565
170GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76136549
171PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76114032
172RUNX2_22187159_ChIP-Seq_PCA_Human0.75488232
173SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75245209
174HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.75237585
175HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73955179
176PIAS1_25552417_ChIP-Seq_VCAP_Human0.73415393
177PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71793021
178OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70458567
179IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69856170
180SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.69798430
181PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65028547
182SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.64775788
183TTF2_22483619_ChIP-Seq_HELA_Human0.63835870
184RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.60103805
185SPI1_23547873_ChIP-Seq_NB4_Human0.59465084
186FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.58892748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.89724060
2MP0005499_abnormal_olfactory_system4.34622766
3MP0005394_taste/olfaction_phenotype4.34622766
4MP0003880_abnormal_central_pattern4.28154461
5MP0005075_abnormal_melanosome_morpholog4.01152737
6MP0003011_delayed_dark_adaptation3.52537110
7MP0004859_abnormal_synaptic_plasticity3.35250767
8MP0008789_abnormal_olfactory_epithelium3.31689937
9MP0005423_abnormal_somatic_nervous2.99275300
10MP0003122_maternal_imprinting2.81354636
11MP0001984_abnormal_olfaction2.72621885
12MP0003183_abnormal_peptide_metabolism2.69905171
13MP0000778_abnormal_nervous_system2.59018764
14MP0002653_abnormal_ependyma_morphology2.49985239
15MP0004264_abnormal_extraembryonic_tissu2.49057515
16MP0002638_abnormal_pupillary_reflex2.43731562
17MP0004858_abnormal_nervous_system2.42968593
18MP0002254_reproductive_system_inflammat2.25084896
19MP0000678_abnormal_parathyroid_gland2.23292533
20MP0004381_abnormal_hair_follicle2.22843527
21MP0003635_abnormal_synaptic_transmissio2.19573094
22MP0004270_analgesia2.15038646
23MP0002332_abnormal_exercise_endurance2.13974324
24MP0008057_abnormal_DNA_replication2.13092743
25MP0002132_abnormal_respiratory_system2.04435460
26MP0003121_genomic_imprinting2.01241888
27MP0003890_abnormal_embryonic-extraembry1.99476592
28MP0000372_irregular_coat_pigmentation1.98925442
29MP0001188_hyperpigmentation1.95233833
30MP0005257_abnormal_intraocular_pressure1.86364539
31MP0002063_abnormal_learning/memory/cond1.86036705
32MP0001529_abnormal_vocalization1.85703218
33MP0004133_heterotaxia1.83106239
34MP0000751_myopathy1.81705614
35MP0002277_abnormal_respiratory_mucosa1.80315538
36MP0005645_abnormal_hypothalamus_physiol1.79702684
37MP0002751_abnormal_autonomic_nervous1.75709125
38MP0000049_abnormal_middle_ear1.75449603
39MP0003938_abnormal_ear_development1.71602184
40MP0002734_abnormal_mechanical_nocicepti1.69975209
41MP0002572_abnormal_emotion/affect_behav1.69880790
42MP0008007_abnormal_cellular_replicative1.68699010
43MP0002064_seizures1.68253253
44MP0002557_abnormal_social/conspecific_i1.63382135
45MP0002396_abnormal_hematopoietic_system1.63269497
46MP0009745_abnormal_behavioral_response1.63251950
47MP0001486_abnormal_startle_reflex1.63095631
48MP0004782_abnormal_surfactant_physiolog1.62559817
49MP0002127_abnormal_cardiovascular_syste1.59139654
50MP0000955_abnormal_spinal_cord1.58869827
51MP0002822_catalepsy1.57223743
52MP0004885_abnormal_endolymph1.52559069
53MP0009046_muscle_twitch1.52200380
54MP0002272_abnormal_nervous_system1.50667923
55MP0001968_abnormal_touch/_nociception1.48065696
56MP0003646_muscle_fatigue1.45791416
57MP0004811_abnormal_neuron_physiology1.39466972
58MP0002233_abnormal_nose_morphology1.38052985
59MP0001970_abnormal_pain_threshold1.37936900
60MP0002184_abnormal_innervation1.36984370
61MP0005409_darkened_coat_color1.36900145
62MP0010368_abnormal_lymphatic_system1.36469356
63MP0004130_abnormal_muscle_cell1.31659984
64MP0002882_abnormal_neuron_morphology1.30668763
65MP0000566_synostosis1.29971204
66MP0003787_abnormal_imprinting1.23411268
67MP0000762_abnormal_tongue_morphology1.20973221
68MP0002152_abnormal_brain_morphology1.18486185
69MP0006035_abnormal_mitochondrial_morpho1.17230620
70MP0000015_abnormal_ear_pigmentation1.13905600
71MP0002735_abnormal_chemical_nociception1.13271210
72MP0005551_abnormal_eye_electrophysiolog1.09530126
73MP0002877_abnormal_melanocyte_morpholog1.09001402
74MP0003828_pulmonary_edema1.08811200
75MP0005171_absent_coat_pigmentation1.08467075
76MP0004957_abnormal_blastocyst_morpholog1.07123841
77MP0004924_abnormal_behavior1.07093112
78MP0005386_behavior/neurological_phenoty1.07093112
79MP0002837_dystrophic_cardiac_calcinosis1.06721708
80MP0003136_yellow_coat_color1.06682069
81MP0002938_white_spotting1.04991210
82MP0005646_abnormal_pituitary_gland1.02851296
83MP0002733_abnormal_thermal_nociception1.02677188
84MP0002909_abnormal_adrenal_gland1.02312745
85MP0004883_abnormal_blood_vessel0.99204724
86MP0001502_abnormal_circadian_rhythm0.98685993
87MP0001986_abnormal_taste_sensitivity0.98523913
88MP0010030_abnormal_orbit_morphology0.97304620
89MP0005253_abnormal_eye_physiology0.96321005
90MP0008877_abnormal_DNA_methylation0.94667123
91MP0002736_abnormal_nociception_after0.94586676
92MP0005508_abnormal_skeleton_morphology0.94141840
93MP0004215_abnormal_myocardial_fiber0.92063698
94MP0002066_abnormal_motor_capabilities/c0.91433657
95MP0002067_abnormal_sensory_capabilities0.91411395
96MP0003861_abnormal_nervous_system0.91097708
97MP0004145_abnormal_muscle_electrophysio0.90030536
98MP0006276_abnormal_autonomic_nervous0.89545314
99MP0002114_abnormal_axial_skeleton0.89493805
100MP0005623_abnormal_meninges_morphology0.89294276
101MP0010094_abnormal_chromosome_stability0.89247368
102MP0000490_abnormal_crypts_of0.88804419
103MP0001672_abnormal_embryogenesis/_devel0.88151480
104MP0005380_embryogenesis_phenotype0.88151480
105MP0001293_anophthalmia0.87720360
106MP0002069_abnormal_eating/drinking_beha0.87518868
107MP0005367_renal/urinary_system_phenotyp0.87445791
108MP0000516_abnormal_urinary_system0.87445791
109MP0000343_altered_response_to0.86475276
110MP0003633_abnormal_nervous_system0.85973942
111MP0002876_abnormal_thyroid_physiology0.85588895
112MP0008995_early_reproductive_senescence0.84592050
113MP0001905_abnormal_dopamine_level0.82846396
114MP0009780_abnormal_chondrocyte_physiolo0.81865247
115MP0003191_abnormal_cellular_cholesterol0.81761697
116MP0003950_abnormal_plasma_membrane0.81604067
117MP0002932_abnormal_joint_morphology0.81360063
118MP0008058_abnormal_DNA_repair0.81108013
119MP0003786_premature_aging0.80979227
120MP0002098_abnormal_vibrissa_morphology0.80555759
121MP0002088_abnormal_embryonic_growth/wei0.79118596
122MP0008569_lethality_at_weaning0.78899941
123MP0006072_abnormal_retinal_apoptosis0.78705884
124MP0000749_muscle_degeneration0.77664575
125MP0003755_abnormal_palate_morphology0.77095062
126MP0002102_abnormal_ear_morphology0.76907682
127MP0002163_abnormal_gland_morphology0.76398637
128MP0003137_abnormal_impulse_conducting0.76352248
129MP0001963_abnormal_hearing_physiology0.75820828
130MP0000313_abnormal_cell_death0.75577293
131MP0003329_amyloid_beta_deposits0.75083406
132MP0001186_pigmentation_phenotype0.74970118
133MP0000631_abnormal_neuroendocrine_gland0.74608844
134MP0003984_embryonic_growth_retardation0.74063803
135MP0001299_abnormal_eye_distance/0.73817194
136MP0008932_abnormal_embryonic_tissue0.72304854
137MP0003186_abnormal_redox_activity0.72245221
138MP0000858_altered_metastatic_potential0.72028256
139MP0006082_CNS_inflammation0.71465506
140MP0005670_abnormal_white_adipose0.71364564
141MP0005535_abnormal_body_temperature0.70702223
142MP0002160_abnormal_reproductive_system0.70367466
143MP0003806_abnormal_nucleotide_metabolis0.69864636
144MP0003077_abnormal_cell_cycle0.69560704
145MP0003935_abnormal_craniofacial_develop0.69518421
146MP0009384_cardiac_valve_regurgitation0.68629258
147MP0000432_abnormal_head_morphology0.68262447
148MP0003763_abnormal_thymus_physiology0.68030235
149MP0002971_abnormal_brown_adipose0.67436415
150MP0003943_abnormal_hepatobiliary_system0.67165641
151MP0003631_nervous_system_phenotype0.66940751
152MP0000350_abnormal_cell_proliferation0.66703237
153MP0002075_abnormal_coat/hair_pigmentati0.66575073
154MP0001835_abnormal_antigen_presentation0.66224841
155MP0004147_increased_porphyrin_level0.65766885
156MP0002116_abnormal_craniofacial_bone0.65585384
157MP0002249_abnormal_larynx_morphology0.65230941
158MP0009250_abnormal_appendicular_skeleto0.65193889
159MP0001270_distended_abdomen0.64797484
160MP0002234_abnormal_pharynx_morphology0.63798196
161MP0003315_abnormal_perineum_morphology0.62835163
162MP0009765_abnormal_xenobiotic_induced0.62804414
163MP0002752_abnormal_somatic_nervous0.62359062
164MP0003690_abnormal_glial_cell0.62350478
165MP0005248_abnormal_Harderian_gland0.61489332
166MP0005195_abnormal_posterior_eye0.61324657
167MP0003942_abnormal_urinary_system0.61035493
168MP0002092_abnormal_eye_morphology0.60989942
169MP0005671_abnormal_response_to0.60856211
170MP0005266_abnormal_metabolism0.60729041
171MP0000026_abnormal_inner_ear0.59725255
172MP0002405_respiratory_system_inflammati0.58338173
173MP0005197_abnormal_uvea_morphology0.57724465
174MP0000428_abnormal_craniofacial_morphol0.56550760

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.38038194
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.05430593
3Hypochromic microcytic anemia (HP:0004840)4.66021686
4Gait imbalance (HP:0002141)4.55991524
5Hepatoblastoma (HP:0002884)4.48635274
6Chromsome breakage (HP:0040012)4.41452779
7Hypoplasia of the fovea (HP:0007750)4.28487793
8Aplasia/Hypoplasia of the fovea (HP:0008060)4.28487793
9Congenital primary aphakia (HP:0007707)4.12810392
10Nephroblastoma (Wilms tumor) (HP:0002667)3.99838805
11Medial flaring of the eyebrow (HP:0010747)3.98430899
12Polyphagia (HP:0002591)3.93130047
13Rib fusion (HP:0000902)3.86594218
14Embryonal renal neoplasm (HP:0011794)3.84833540
15Nephrogenic diabetes insipidus (HP:0009806)3.82801036
16Reduced antithrombin III activity (HP:0001976)3.79792916
17True hermaphroditism (HP:0010459)3.73425867
18Abnormal lung lobation (HP:0002101)3.60205085
19Rectal fistula (HP:0100590)3.59067427
20Rectovaginal fistula (HP:0000143)3.59067427
21Type I transferrin isoform profile (HP:0003642)3.44576290
22Abnormality of the fovea (HP:0000493)3.36619790
23Nasolacrimal duct obstruction (HP:0000579)3.32512263
24Occipital encephalocele (HP:0002085)3.30529277
25Pancreatic fibrosis (HP:0100732)3.29022437
26Intestinal fistula (HP:0100819)3.28429449
27Vaginal atresia (HP:0000148)3.19511764
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17201667
29Myokymia (HP:0002411)3.16436918
30Bile duct proliferation (HP:0001408)3.16367889
31Abnormal biliary tract physiology (HP:0012439)3.16367889
32Pancreatic cysts (HP:0001737)3.11778474
33Microvesicular hepatic steatosis (HP:0001414)3.07148322
34Nephronophthisis (HP:0000090)3.06051038
35Abnormality of midbrain morphology (HP:0002418)3.04433809
36Molar tooth sign on MRI (HP:0002419)3.04433809
37Genital tract atresia (HP:0001827)3.03594118
38Anomalous pulmonary venous return (HP:0010772)3.03001441
39Poor coordination (HP:0002370)2.96718590
40Chronic hepatic failure (HP:0100626)2.93735411
41Vaginal fistula (HP:0004320)2.93447021
42Meckel diverticulum (HP:0002245)2.91752675
43Multiple enchondromatosis (HP:0005701)2.90180885
44Partial duplication of thumb phalanx (HP:0009944)2.84514607
45Aplasia/Hypoplasia of the lens (HP:0008063)2.77198896
46Periauricular skin pits (HP:0100277)2.76876965
47Preauricular pit (HP:0004467)2.76876965
48Abnormal eating behavior (HP:0100738)2.72173915
49Amyotrophic lateral sclerosis (HP:0007354)2.71368584
50Abnormality of the ileum (HP:0001549)2.71202464
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.70064489
52Febrile seizures (HP:0002373)2.69755958
53Supernumerary spleens (HP:0009799)2.67699593
54Ankle clonus (HP:0011448)2.67666267
55Hyperinsulinemic hypoglycemia (HP:0000825)2.66213747
56Specific learning disability (HP:0001328)2.65762831
57Pendular nystagmus (HP:0012043)2.63437918
58Cystic liver disease (HP:0006706)2.63313716
593-Methylglutaconic aciduria (HP:0003535)2.63186936
60Failure to thrive in infancy (HP:0001531)2.61848252
61Abnormality of the lacrimal duct (HP:0011481)2.60812556
62Drooling (HP:0002307)2.58405486
63Impulsivity (HP:0100710)2.56119410
64Abnormality of the pulmonary veins (HP:0011718)2.56026016
65Amblyopia (HP:0000646)2.55791654
66Upper limb muscle weakness (HP:0003484)2.54990678
67Abnormality of the phalanges of the hallux (HP:0010057)2.54772239
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54636027
69Cortical dysplasia (HP:0002539)2.52852251
70Aplastic anemia (HP:0001915)2.50708326
71Microretrognathia (HP:0000308)2.50564712
72Testicular atrophy (HP:0000029)2.49794621
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.43271958
74Petechiae (HP:0000967)2.42196047
75Left ventricular hypertrophy (HP:0001712)2.41077349
76Excessive salivation (HP:0003781)2.39657376
77Aplasia/Hypoplasia of the macula (HP:0008059)2.39403809
78Abnormality of the renal medulla (HP:0100957)2.38259914
79Abnormality of the nasolacrimal system (HP:0000614)2.36849663
80Postaxial foot polydactyly (HP:0001830)2.35043022
81Congenital hepatic fibrosis (HP:0002612)2.34695213
82Focal seizures (HP:0007359)2.32997463
83Partial duplication of the phalanx of hand (HP:0009999)2.32378005
84Tongue fasciculations (HP:0001308)2.32036283
85Anencephaly (HP:0002323)2.31913194
86Bifid tongue (HP:0010297)2.30685058
87Decreased testicular size (HP:0008734)2.26032959
88Rhabdomyosarcoma (HP:0002859)2.25998980
89Limb dystonia (HP:0002451)2.25966924
90Narrow forehead (HP:0000341)2.25946770
91Focal motor seizures (HP:0011153)2.24502306
92Septo-optic dysplasia (HP:0100842)2.23968547
93Absent speech (HP:0001344)2.21135803
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.19231954
95Optic nerve coloboma (HP:0000588)2.16196605
96Supranuclear gaze palsy (HP:0000605)2.16111965
97Postaxial hand polydactyly (HP:0001162)2.14273582
98Abnormality of the aortic arch (HP:0012303)2.12199644
99Aplasia/Hypoplasia of the spleen (HP:0010451)2.11885208
100Osteomalacia (HP:0002749)2.11663177
101Progressive external ophthalmoplegia (HP:0000590)2.09338317
102Asplenia (HP:0001746)2.08874873
103Abnormality of the salivary glands (HP:0010286)2.08360726
104Exotropia (HP:0000577)2.08123678
105Generalized hypotonia (HP:0001290)2.07545480
106Duodenal stenosis (HP:0100867)2.06835731
107Small intestinal stenosis (HP:0012848)2.06835731
108Duplication of thumb phalanx (HP:0009942)2.06483861
109Abnormality of the preputium (HP:0100587)2.06144667
110Fused cervical vertebrae (HP:0002949)2.04618249
111Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04102413
112Hypoplasia of the brainstem (HP:0002365)2.04102413
113Intellectual disability, severe (HP:0010864)2.03907473
114Spastic gait (HP:0002064)2.02474373
115Abnormal respiratory motile cilium physiology (HP:0012261)2.02154505
116Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01845900
117Retinal dysplasia (HP:0007973)1.98458627
118Neoplasm of striated muscle (HP:0009728)1.96687122
119Abnormal respiratory epithelium morphology (HP:0012253)1.96566248
120Abnormal respiratory motile cilium morphology (HP:0005938)1.96566248
121Agitation (HP:0000713)1.95825204
122Abnormal ciliary motility (HP:0012262)1.94865494
123Supernumerary nipples (HP:0002558)1.94681109
124Hip dysplasia (HP:0001385)1.94284574
125Ependymoma (HP:0002888)1.93897596
126Neoplasm of the tracheobronchial system (HP:0100552)1.92923683
127Embryonal neoplasm (HP:0002898)1.92470113
128Muscle fibrillation (HP:0010546)1.92278270
129Atonic seizures (HP:0010819)1.92025631
130Atelectasis (HP:0100750)1.91583490
131Combined immunodeficiency (HP:0005387)1.90104227
132Abnormality of chromosome segregation (HP:0002916)1.89822717
133Mesomelia (HP:0003027)1.89283317
134Polymicrogyria (HP:0002126)1.88380565
135Hyperglycinemia (HP:0002154)1.88338360
136Tubulointerstitial nephritis (HP:0001970)1.88317575
137Abnormality of the lower motor neuron (HP:0002366)1.88110943
138Horizontal nystagmus (HP:0000666)1.87642807
139Rhinitis (HP:0012384)1.87590027
140Scrotal hypoplasia (HP:0000046)1.86860814
141Broad foot (HP:0001769)1.86135834
142Curly hair (HP:0002212)1.85548354
143Abnormality of chromosome stability (HP:0003220)1.84747943
144Oculomotor apraxia (HP:0000657)1.83699598
145Hyperventilation (HP:0002883)1.83478995
146Abnormal protein glycosylation (HP:0012346)1.82740715
147Abnormal glycosylation (HP:0012345)1.82740715
148Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82740715
149Abnormal protein N-linked glycosylation (HP:0012347)1.82740715
150Prominent nasal bridge (HP:0000426)1.82662990
151Abnormality of the duodenum (HP:0002246)1.82211079
152Hypsarrhythmia (HP:0002521)1.82189432
153Fetal akinesia sequence (HP:0001989)1.82115990
154Sclerocornea (HP:0000647)1.81755264
155Hand muscle atrophy (HP:0009130)1.80399129
156Hypochromic anemia (HP:0001931)1.79862507
157Cerebellar dysplasia (HP:0007033)1.79828578
158Lissencephaly (HP:0001339)1.79028114
159Abnormality of the labia minora (HP:0012880)1.78815942
160EEG with generalized epileptiform discharges (HP:0011198)1.78412606
161Chorioretinal coloboma (HP:0000567)1.77564259
162Facial cleft (HP:0002006)1.77267937
163Epileptiform EEG discharges (HP:0011182)1.76779218
164Adrenal hypoplasia (HP:0000835)1.76689134
165Epileptic encephalopathy (HP:0200134)1.76481550
166Ketoacidosis (HP:0001993)1.76197119
167Skin pits (HP:0100276)1.75751591
168Intellectual disability, moderate (HP:0002342)1.75639252
169Pancreatic islet-cell hyperplasia (HP:0004510)1.75224812
170Difficulty running (HP:0009046)1.75102162
171Distal lower limb muscle weakness (HP:0009053)1.74966526
172Neuroblastic tumors (HP:0004376)1.74394504
173Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.74394504
174Neuroblastoma (HP:0003006)1.74394504
175Primitive neuroectodermal tumor (HP:0030065)1.74394504
176Abnormality of the intervertebral disk (HP:0005108)1.73898024
177Shawl scrotum (HP:0000049)1.73296296
178Micropenis (HP:0000054)1.72993434
179Rimmed vacuoles (HP:0003805)1.72163021
180Optic nerve hypoplasia (HP:0000609)1.71887271
181Malignant neoplasm of the central nervous system (HP:0100836)1.71767197
182Bone marrow hypocellularity (HP:0005528)1.71755314
183Elevated erythrocyte sedimentation rate (HP:0003565)1.71381911
184Sensory axonal neuropathy (HP:0003390)1.71309772
185Hypoplasia of the corpus callosum (HP:0002079)1.70684521
186Neoplasm of the heart (HP:0100544)1.69609827
187Aganglionic megacolon (HP:0002251)1.69290195
188Ulnar claw (HP:0001178)1.67836393
189Pachygyria (HP:0001302)1.66993081
190Poor suck (HP:0002033)1.66815503
191Hammertoe (HP:0001765)1.64693902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.05765325
2MARK15.05016669
3CDK124.44947094
4GRK54.16687245
5GRK13.65737634
6ADRBK23.11661766
7GRK72.89846398
8AKT32.83661640
9EPHA42.60037428
10PINK12.58675523
11TGFBR22.58214514
12MAP3K42.57320486
13TRIM282.50768041
14EPHA32.47797352
15CASK2.46965623
16NTRK22.39249864
17EIF2AK22.33990162
18GRK62.25687425
19ERN12.24081390
20CSF1R2.23493745
21MATK2.02778936
22MAPK71.98789620
23WNK31.98443390
24DYRK1B1.85513530
25DAPK21.85290366
26YES11.81776297
27SRPK11.80401683
28NTRK31.68277999
29MAPK151.67296571
30MAP2K71.66121946
31PRKD31.62061234
32PKN11.58914843
33PAK31.57055587
34TTK1.52696712
35MAP2K41.51964424
36PRPF4B1.48593558
37SGK21.42701793
38PAK61.41536089
39CAMK41.37444104
40ZAK1.36221838
41MUSK1.35418055
42SIK21.31730798
43CAMKK11.30424969
44TEC1.29504251
45BCKDK1.28652242
46PIM21.27033658
47MAP4K21.26317804
48BCR1.25681738
49NTRK11.21697910
50MAP2K61.17549327
51FGFR31.16259778
52ADRBK11.16202125
53FRK1.15644033
54PHKG21.15532377
55PHKG11.15532377
56EPHB21.14662430
57CAMKK21.14179382
58SIK31.13771631
59STK101.12508539
60CLK11.11745144
61MOS1.10799553
62UHMK11.09710977
63STK38L1.05993484
64CDK51.05176180
65MKNK11.04826932
66CDK81.04453896
67FGFR21.04320874
68CAMK11.03858233
69DYRK21.03321011
70DYRK30.99885135
71CDK190.98851252
72MAP3K70.96944380
73ERBB30.94712363
74PRKCH0.92227234
75PRKAA10.91877553
76ACVR1B0.91627535
77PRKG20.91470203
78IRAK40.89733063
79MAP3K140.89227447
80MKNK20.88380576
81BMPR1B0.88225050
82CSNK1G20.87941702
83SGK4940.87124293
84SGK2230.87124293
85STK240.85055629
86BLK0.84975191
87EIF2AK10.84756835
88BRSK20.83980347
89EPHB10.83099790
90WNK10.82336602
91BMPR20.80169933
92CDK70.79564473
93MINK10.79243026
94PRKD20.78205839
95PKN20.77463412
96MAPK130.74881826
97MARK30.73543593
98SGK30.73390417
99STK110.72251382
100PLK10.71244377
101HIPK20.69667979
102MAP3K60.68811793
103CSNK1G30.67774487
104TAOK30.67649561
105CHEK20.66854687
106MARK20.65964361
107CAMK1G0.64679506
108TYRO30.64296271
109MAPK120.63679979
110IKBKB0.62397673
111PRKCZ0.61584517
112TXK0.61435363
113STK380.59393056
114CDK30.58352734
115CSNK1A1L0.56806621
116CSNK1G10.56116917
117RPS6KA20.54803997
118TSSK60.51781895
119PRKCD0.50563782
120FER0.49322496
121AURKA0.49022748
122MAPK40.48325771
123CAMK2A0.45466587
124IRAK20.43531840
125DYRK1A0.42991538
126TNK20.42596855
127FLT30.42540705
128CAMK1D0.42510630
129BRSK10.42163274
130CDC70.41836257
131PRKD10.41685922
132TRPM70.41657598
133PRKACA0.41129651
134PRKAA20.40998096
135CDK180.40778867
136CDK150.39390688
137PRKCG0.39278009
138RPS6KA40.38634892
139PIM10.38096569
140CDK11A0.37591089
141CDK140.36892229
142OBSCN0.35629862
143IGF1R0.35536971
144BMX0.35342517
145PRKCQ0.35208766
146MYLK0.34464845
147EEF2K0.34358653
148IRAK30.31964395
149MAPK80.31875169
150ITK0.31805882
151MAP2K30.31556852
152PAK40.31400209
153CCNB10.30859756
154PRKACB0.30716917
155CSK0.29533701
156EIF2AK30.29415044
157MAPK90.28912244
158CHUK0.28260685
159MAPKAPK20.27522148
160VRK10.26058370
161PRKCI0.25506222
162MST40.25478244
163KIT0.25353806
164AKT20.23429897
165MAPK30.22388358
166CHEK10.21508673
167INSR0.20955970
168ATM0.20028857
169RPS6KB10.19654892
170TNIK0.19298063
171PRKCE0.18949650
172CDK20.18447984

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.99813131
2Vitamin B6 metabolism_Homo sapiens_hsa007503.49760290
3Arachidonic acid metabolism_Homo sapiens_hsa005903.27848725
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88032932
5Nicotine addiction_Homo sapiens_hsa050332.53873969
6Fructose and mannose metabolism_Homo sapiens_hsa000512.38244482
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33311892
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27963376
9Fanconi anemia pathway_Homo sapiens_hsa034602.24164363
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.15333901
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13044433
12Butanoate metabolism_Homo sapiens_hsa006502.03208356
13Galactose metabolism_Homo sapiens_hsa000521.97784360
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.96350846
15DNA replication_Homo sapiens_hsa030301.94069889
16Homologous recombination_Homo sapiens_hsa034401.91811885
17GABAergic synapse_Homo sapiens_hsa047271.89844704
18Basal transcription factors_Homo sapiens_hsa030221.88980199
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87294329
20Fatty acid metabolism_Homo sapiens_hsa012121.82434015
21Steroid biosynthesis_Homo sapiens_hsa001001.82333921
22Propanoate metabolism_Homo sapiens_hsa006401.80686931
23Synaptic vesicle cycle_Homo sapiens_hsa047211.76311665
24Other glycan degradation_Homo sapiens_hsa005111.75957089
25Axon guidance_Homo sapiens_hsa043601.74371705
26Linoleic acid metabolism_Homo sapiens_hsa005911.72802620
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70157992
28Thyroid cancer_Homo sapiens_hsa052161.68413332
29Insulin secretion_Homo sapiens_hsa049111.64956751
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62416063
31Dopaminergic synapse_Homo sapiens_hsa047281.61899284
32Morphine addiction_Homo sapiens_hsa050321.61479146
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61033132
34Glutamatergic synapse_Homo sapiens_hsa047241.60355414
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59411730
36Circadian entrainment_Homo sapiens_hsa047131.58406996
37Base excision repair_Homo sapiens_hsa034101.57452528
38Mismatch repair_Homo sapiens_hsa034301.49052583
39Fatty acid elongation_Homo sapiens_hsa000621.47180167
40Cocaine addiction_Homo sapiens_hsa050301.46355894
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.43704119
42RNA polymerase_Homo sapiens_hsa030201.42743785
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38853121
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37288238
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33450759
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.33022779
47Amphetamine addiction_Homo sapiens_hsa050311.31737643
48Regulation of autophagy_Homo sapiens_hsa041401.30597551
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27021951
50RNA degradation_Homo sapiens_hsa030181.22158312
51Cell cycle_Homo sapiens_hsa041101.21993932
52Non-homologous end-joining_Homo sapiens_hsa034501.19172421
53One carbon pool by folate_Homo sapiens_hsa006701.19080846
54Phototransduction_Homo sapiens_hsa047441.15586105
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15428028
56Cholinergic synapse_Homo sapiens_hsa047251.14462531
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.14404311
58Fatty acid degradation_Homo sapiens_hsa000711.14030675
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12800066
60Ribosome_Homo sapiens_hsa030101.10834924
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09387409
62NF-kappa B signaling pathway_Homo sapiens_hsa040641.09150840
63Primary immunodeficiency_Homo sapiens_hsa053401.07038479
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06071353
65Glycerophospholipid metabolism_Homo sapiens_hsa005641.03769538
66Herpes simplex infection_Homo sapiens_hsa051681.03216900
67Ether lipid metabolism_Homo sapiens_hsa005651.03058650
68Pyrimidine metabolism_Homo sapiens_hsa002401.01810160
69Pyruvate metabolism_Homo sapiens_hsa006201.01281771
70Taste transduction_Homo sapiens_hsa047421.00849676
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99971912
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.98873639
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96863564
74p53 signaling pathway_Homo sapiens_hsa041150.94953734
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93981493
76cAMP signaling pathway_Homo sapiens_hsa040240.93538778
77Hematopoietic cell lineage_Homo sapiens_hsa046400.91968000
78Proteasome_Homo sapiens_hsa030500.90804385
79Oxytocin signaling pathway_Homo sapiens_hsa049210.90231182
80Fatty acid biosynthesis_Homo sapiens_hsa000610.88746669
81Nitrogen metabolism_Homo sapiens_hsa009100.88616514
82Dilated cardiomyopathy_Homo sapiens_hsa054140.88554914
83Olfactory transduction_Homo sapiens_hsa047400.88195518
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85911890
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82268296
86AMPK signaling pathway_Homo sapiens_hsa041520.82099520
87Peroxisome_Homo sapiens_hsa041460.80222565
88Type II diabetes mellitus_Homo sapiens_hsa049300.79698009
89Ovarian steroidogenesis_Homo sapiens_hsa049130.77614380
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77330944
91Calcium signaling pathway_Homo sapiens_hsa040200.77049916
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76666345
93Pathways in cancer_Homo sapiens_hsa052000.75991392
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75215946
95Renin secretion_Homo sapiens_hsa049240.74972999
96Basal cell carcinoma_Homo sapiens_hsa052170.74700230
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74649443
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.74133842
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73432127
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73157511
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72804727
102Serotonergic synapse_Homo sapiens_hsa047260.72242059
103beta-Alanine metabolism_Homo sapiens_hsa004100.72157639
104Lysine degradation_Homo sapiens_hsa003100.71925337
105RNA transport_Homo sapiens_hsa030130.71833347
106Glycerolipid metabolism_Homo sapiens_hsa005610.71267557
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70404353
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69998331
109Gap junction_Homo sapiens_hsa045400.69937755
110Cardiac muscle contraction_Homo sapiens_hsa042600.69831171
111Purine metabolism_Homo sapiens_hsa002300.69503326
112Glucagon signaling pathway_Homo sapiens_hsa049220.68529476
113PPAR signaling pathway_Homo sapiens_hsa033200.68039774
114Wnt signaling pathway_Homo sapiens_hsa043100.67748098
115Acute myeloid leukemia_Homo sapiens_hsa052210.67236027
116Gastric acid secretion_Homo sapiens_hsa049710.66517086
117Nucleotide excision repair_Homo sapiens_hsa034200.66073258
118Long-term depression_Homo sapiens_hsa047300.66014812
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65403109
120Melanogenesis_Homo sapiens_hsa049160.64771775
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64111450
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63695864
123Spliceosome_Homo sapiens_hsa030400.63397341
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62861759
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62601154
126Rheumatoid arthritis_Homo sapiens_hsa053230.62487794
127Sphingolipid metabolism_Homo sapiens_hsa006000.62233420
128Apoptosis_Homo sapiens_hsa042100.61969091
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.61742649
130Autoimmune thyroid disease_Homo sapiens_hsa053200.61702149
131Long-term potentiation_Homo sapiens_hsa047200.60907274
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60604758
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60298502
134mRNA surveillance pathway_Homo sapiens_hsa030150.59665470
135Rap1 signaling pathway_Homo sapiens_hsa040150.59402913
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.57681889
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57446582
138African trypanosomiasis_Homo sapiens_hsa051430.56440880
139Measles_Homo sapiens_hsa051620.55947732
140Notch signaling pathway_Homo sapiens_hsa043300.54987869
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52825345
142Legionellosis_Homo sapiens_hsa051340.52491212
143Carbon metabolism_Homo sapiens_hsa012000.51264712
144Ras signaling pathway_Homo sapiens_hsa040140.50785888
145Influenza A_Homo sapiens_hsa051640.50697367
146Circadian rhythm_Homo sapiens_hsa047100.50025117
147Choline metabolism in cancer_Homo sapiens_hsa052310.49448200
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49401583
149GnRH signaling pathway_Homo sapiens_hsa049120.49034344
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49023592
151Salivary secretion_Homo sapiens_hsa049700.48164808
152Hedgehog signaling pathway_Homo sapiens_hsa043400.48012807
153Insulin signaling pathway_Homo sapiens_hsa049100.47537974
154ABC transporters_Homo sapiens_hsa020100.47055483
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.46780426
156Chemical carcinogenesis_Homo sapiens_hsa052040.46157779
157Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46051468
158MicroRNAs in cancer_Homo sapiens_hsa052060.45745654
159mTOR signaling pathway_Homo sapiens_hsa041500.45027280
160Sulfur relay system_Homo sapiens_hsa041220.44887925
161Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43353964
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42505819
163Melanoma_Homo sapiens_hsa052180.41745835
164Leishmaniasis_Homo sapiens_hsa051400.41503336
165Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40793549
166Inositol phosphate metabolism_Homo sapiens_hsa005620.38298084
167Protein export_Homo sapiens_hsa030600.37704009
168Epstein-Barr virus infection_Homo sapiens_hsa051690.35968821
169HTLV-I infection_Homo sapiens_hsa051660.33462026
170SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33074370
171Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32989491
172Adherens junction_Homo sapiens_hsa045200.32474705
173Hepatitis C_Homo sapiens_hsa051600.31442933
174Leukocyte transendothelial migration_Homo sapiens_hsa046700.31098713
175Colorectal cancer_Homo sapiens_hsa052100.30945541
176Graft-versus-host disease_Homo sapiens_hsa053320.29440961
177Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29004263
178Phagosome_Homo sapiens_hsa041450.27554609
179Antigen processing and presentation_Homo sapiens_hsa046120.26391910
180Pertussis_Homo sapiens_hsa051330.25764041

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