FAM21A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)3.88032157
2hypotonic response (GO:0006971)3.49429142
3barbed-end actin filament capping (GO:0051016)3.44167879
4COPI coating of Golgi vesicle (GO:0048205)3.39371365
5Golgi transport vesicle coating (GO:0048200)3.39371365
6embryonic process involved in female pregnancy (GO:0060136)3.37627429
7endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.33868777
8negative regulation of fatty acid transport (GO:2000192)3.33124342
9skin morphogenesis (GO:0043589)3.26528364
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09238585
11cortical actin cytoskeleton organization (GO:0030866)3.06349058
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04789407
13response to laminar fluid shear stress (GO:0034616)2.97448808
14regulation of early endosome to late endosome transport (GO:2000641)2.96357422
15negative regulation of erythrocyte differentiation (GO:0045647)2.95152943
16stress fiber assembly (GO:0043149)2.93206439
17pinocytosis (GO:0006907)2.90013639
18mannose metabolic process (GO:0006013)2.86150612
19histone H3-K36 demethylation (GO:0070544)2.84679040
20regulation of ARF protein signal transduction (GO:0032012)2.84044148
21antigen processing and presentation of endogenous antigen (GO:0019883)2.81311308
22cerebellar granule cell differentiation (GO:0021707)2.75913896
23COPII vesicle coating (GO:0048208)2.73912237
24regulation of extracellular matrix disassembly (GO:0010715)2.73370074
25sphingomyelin metabolic process (GO:0006684)2.71948175
26cortical cytoskeleton organization (GO:0030865)2.71314542
27fructose metabolic process (GO:0006000)2.69995451
28negative regulation of cell killing (GO:0031342)2.69910412
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69910412
30negative regulation of protein localization to plasma membrane (GO:1903077)2.68558942
31negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68394489
32cytoskeletal anchoring at plasma membrane (GO:0007016)2.67543555
33cell volume homeostasis (GO:0006884)2.63385362
34regulation of cholesterol homeostasis (GO:2000188)2.61828991
35cellular response to thyroid hormone stimulus (GO:0097067)2.58962998
36neutrophil activation involved in immune response (GO:0002283)2.56220947
37positive regulation of receptor recycling (GO:0001921)2.55574467
38glycosphingolipid catabolic process (GO:0046479)2.52923575
39vesicle coating (GO:0006901)2.50194736
40positive regulation of Cdc42 GTPase activity (GO:0043089)2.47800105
41response to muramyl dipeptide (GO:0032495)2.45154551
42negative regulation of skeletal muscle tissue development (GO:0048642)2.42240025
43cell adhesion mediated by integrin (GO:0033627)2.41764095
44regulation of leukocyte degranulation (GO:0043300)2.39587077
45receptor recycling (GO:0001881)2.39418816
46positive regulation of gamma-delta T cell activation (GO:0046645)2.38837962
47negative regulation of glycoprotein biosynthetic process (GO:0010561)2.36092342
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36031077
49regulation of macrophage cytokine production (GO:0010935)2.35391645
50antigen processing and presentation via MHC class Ib (GO:0002475)2.34217106
51positive regulation of extracellular matrix organization (GO:1903055)2.33677496
52positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.32843366
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32730594
54regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32521081
55macroautophagy (GO:0016236)2.32272148
56detection of other organism (GO:0098543)2.32090982
57cellular response to fluid shear stress (GO:0071498)2.30055438
58phosphatidylinositol dephosphorylation (GO:0046856)2.27668355
59response to peptidoglycan (GO:0032494)2.27351653
60cell-substrate junction assembly (GO:0007044)2.26291165
61response to fluid shear stress (GO:0034405)2.25666157
62regulation of transforming growth factor beta1 production (GO:0032908)2.24971529
63response to thyroid hormone (GO:0097066)2.24577174
64apoptotic cell clearance (GO:0043277)2.23884517
65hyaluronan catabolic process (GO:0030214)2.23656681
66regulation of nucleobase-containing compound transport (GO:0032239)2.21652322
67glycolipid catabolic process (GO:0019377)2.21153710
68regulation of ARF GTPase activity (GO:0032312)2.20834127
69regulation of NFAT protein import into nucleus (GO:0051532)2.20349618
70adherens junction assembly (GO:0034333)2.18513590
71epithelial cell differentiation involved in prostate gland development (GO:0060742)2.17412599
72focal adhesion assembly (GO:0048041)2.16895824
73cell-substrate adherens junction assembly (GO:0007045)2.16895824
74membrane raft organization (GO:0031579)2.16055230
75positive regulation of cellular amide metabolic process (GO:0034250)2.15967379
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.15662260
77peptide catabolic process (GO:0043171)2.14837315
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.14347645
79mammary gland epithelial cell proliferation (GO:0033598)2.13897026
80regulation of lipid kinase activity (GO:0043550)2.13779303
81detection of molecule of bacterial origin (GO:0032490)2.13061800
82modulation by symbiont of host immune response (GO:0052553)2.12512412
83positive regulation by symbiont of host defense response (GO:0052509)2.12512412
84modulation by symbiont of host defense response (GO:0052031)2.12512412
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.12512412
86modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.12512412
87positive regulation by organism of defense response of other organism involved in symbiotic interact2.12512412
88positive regulation of macrophage cytokine production (GO:0060907)2.12068026
89phospholipid dephosphorylation (GO:0046839)2.11424315
90membrane protein ectodomain proteolysis (GO:0006509)2.10371476
91insulin-like growth factor receptor signaling pathway (GO:0048009)2.09599076
92protein localization to cell surface (GO:0034394)2.09562766
93peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.08742433
94filopodium assembly (GO:0046847)2.08698904
95oligosaccharide catabolic process (GO:0009313)2.07872461
96regulation of RNA export from nucleus (GO:0046831)2.07202899
97regulation of T-helper 2 cell differentiation (GO:0045628)2.07133927
98positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.06985037
99negative regulation of glycoprotein metabolic process (GO:1903019)2.05121530
100detection of bacterium (GO:0016045)2.04984759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.03873181
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.52402056
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09879298
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.69064682
5MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66623206
6CLOCK_20551151_ChIP-Seq_293T_Human2.57522342
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54831529
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37740561
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34745382
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30859427
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20187873
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.17143029
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14054829
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07941853
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93606888
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91736209
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.91262671
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.90463768
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.89364311
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87916075
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84765698
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83095115
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.82083854
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80175304
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.79832603
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73705408
27KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71827226
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69320384
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.68603017
30TCF7_22412390_ChIP-Seq_EML_Mouse1.67187153
31* SPI1_23127762_ChIP-Seq_K562_Human1.66375545
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60903738
33VDR_24763502_ChIP-Seq_THP-1_Human1.58601389
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.57941024
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56940877
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54385929
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54171216
38* TFEB_21752829_ChIP-Seq_HELA_Human1.54156980
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53097293
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51742431
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51736843
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51606970
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50755533
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50755533
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50605752
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49940099
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.49535909
48GATA1_19941826_ChIP-Seq_K562_Human1.49101433
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47066149
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47023706
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.43139674
52ZNF263_19887448_ChIP-Seq_K562_Human1.39439078
53RACK7_27058665_Chip-Seq_MCF-7_Human1.37403002
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36640637
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.36078112
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.35506356
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.35506356
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34821297
59MAF_26560356_Chip-Seq_TH1_Human1.34684601
60VDR_21846776_ChIP-Seq_THP-1_Human1.33756456
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32165876
62RUNX_20019798_ChIP-Seq_JUKART_Human1.32078186
63MYC_22102868_ChIP-Seq_BL_Human1.31936505
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.30745818
65KDM2B_26808549_Chip-Seq_DND41_Human1.29555672
66VDR_24787735_ChIP-Seq_THP-1_Human1.27583709
67GATA1_22025678_ChIP-Seq_K562_Human1.26061067
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25631859
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22437120
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22197720
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19740707
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19688364
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18918396
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18562518
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.18055775
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17864762
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.17259781
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14594977
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14004566
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.13999997
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13984104
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13356299
83GATA2_19941826_ChIP-Seq_K562_Human1.13284589
84KDM2B_26808549_Chip-Seq_K562_Human1.13138518
85MYB_26560356_Chip-Seq_TH1_Human1.12661131
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11197852
87PU_27001747_Chip-Seq_BMDM_Mouse1.11036802
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11003802
89SPI1_23547873_ChIP-Seq_NB4_Human1.10415668
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08133690
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.04467035
92LXR_22292898_ChIP-Seq_THP-1_Human1.04342809
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.03892816
94BRD4_25478319_ChIP-Seq_HGPS_Human1.03211975
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.01937558
96MYB_26560356_Chip-Seq_TH2_Human1.01719696
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01008157
98NCOR1_26117541_ChIP-Seq_K562_Human1.00603899
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00362786
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98101760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.54186975
2MP0005058_abnormal_lysosome_morphology3.18916935
3MP0003705_abnormal_hypodermis_morpholog2.99380900
4MP0003172_abnormal_lysosome_physiology2.95216118
5MP0010234_abnormal_vibrissa_follicle2.85322867
6MP0003300_gastrointestinal_ulcer2.55960079
7MP0003191_abnormal_cellular_cholesterol2.54658887
8MP0003303_peritoneal_inflammation2.41743400
9MP0003566_abnormal_cell_adhesion2.37300276
10MP0002877_abnormal_melanocyte_morpholog2.35324301
11MP0009840_abnormal_foam_cell2.33602401
12MP0005409_darkened_coat_color2.22593413
13MP0006054_spinal_hemorrhage2.21656207
14MP0003091_abnormal_cell_migration2.11852458
15MP0008260_abnormal_autophagy2.07089888
16MP0010352_gastrointestinal_tract_polyps2.05104103
17MP0003436_decreased_susceptibility_to2.02539008
18MP0003828_pulmonary_edema2.00165214
19MP0005451_abnormal_body_composition1.96220189
20MP0005275_abnormal_skin_tensile1.95064591
21MP0003656_abnormal_erythrocyte_physiolo1.78441233
22MP0003183_abnormal_peptide_metabolism1.73994629
23MP0001958_emphysema1.68441850
24MP0003724_increased_susceptibility_to1.65192369
25MP0001835_abnormal_antigen_presentation1.63504261
26MP0003279_aneurysm1.62012994
27MP0010386_abnormal_urinary_bladder1.59779807
28MP0000465_gastrointestinal_hemorrhage1.54902001
29MP0001849_ear_inflammation1.48368512
30MP0000604_amyloidosis1.47365384
31MP0002060_abnormal_skin_morphology1.44925193
32MP0004272_abnormal_basement_membrane1.43787196
33MP0004947_skin_inflammation1.41888618
34MP0005076_abnormal_cell_differentiation1.41357774
35MP0001542_abnormal_bone_strength1.37347106
36MP0005623_abnormal_meninges_morphology1.36978964
37MP0002419_abnormal_innate_immunity1.34471956
38MP0005464_abnormal_platelet_physiology1.30737087
39MP0002998_abnormal_bone_remodeling1.30283818
40MP0003329_amyloid_beta_deposits1.27473886
41MP0003453_abnormal_keratinocyte_physiol1.24604162
42MP0006082_CNS_inflammation1.21447870
43MP0000858_altered_metastatic_potential1.20578641
44MP0002009_preneoplasia1.20247820
45MP0003950_abnormal_plasma_membrane1.18497558
46MP0005023_abnormal_wound_healing1.18360108
47MP0001533_abnormal_skeleton_physiology1.17706002
48MP0005621_abnormal_cell_physiology1.17181625
49MP0002896_abnormal_bone_mineralization1.16045558
50MP0003763_abnormal_thymus_physiology1.13361238
51MP0003448_altered_tumor_morphology1.11345145
52MP0001915_intracranial_hemorrhage1.10572781
53MP0000767_abnormal_smooth_muscle1.10469247
54MP0005257_abnormal_intraocular_pressure1.09217090
55MP0008004_abnormal_stomach_pH1.08921457
56MP0003868_abnormal_feces_composition1.07955075
57MP0005025_abnormal_response_to1.07356943
58MP0010155_abnormal_intestine_physiology1.06477315
59MP0005000_abnormal_immune_tolerance1.06281628
60MP0005165_increased_susceptibility_to1.06162621
61MP0004510_myositis1.05275452
62MP0002166_altered_tumor_susceptibility1.04083671
63MP0010368_abnormal_lymphatic_system1.03708791
64MP0008874_decreased_physiological_sensi1.02786729
65MP0004036_abnormal_muscle_relaxation1.01333183
66MP0000685_abnormal_immune_system1.01208502
67MP0005387_immune_system_phenotype1.01030358
68MP0001790_abnormal_immune_system1.01030358
69MP0001851_eye_inflammation0.98648719
70MP0000015_abnormal_ear_pigmentation0.97918511
71MP0005503_abnormal_tendon_morphology0.97452163
72MP0005166_decreased_susceptibility_to0.97212367
73MP0005164_abnormal_response_to0.96868989
74MP0004264_abnormal_extraembryonic_tissu0.94754558
75MP0003690_abnormal_glial_cell0.94442194
76MP0003866_abnormal_defecation0.90830247
77MP0004484_altered_response_of0.90629852
78MP0002796_impaired_skin_barrier0.90123491
79MP0002452_abnormal_antigen_presenting0.88612604
80MP0000343_altered_response_to0.88460852
81MP0003795_abnormal_bone_structure0.87179418
82MP0000920_abnormal_myelination0.86763930
83MP0000751_myopathy0.85836273
84MP0002396_abnormal_hematopoietic_system0.85617678
85MP0001243_abnormal_dermal_layer0.85151394
86MP0003221_abnormal_cardiomyocyte_apopto0.84097232
87MP0001800_abnormal_humoral_immune0.83035333
88MP0009785_altered_susceptibility_to0.82577921
89MP0004084_abnormal_cardiac_muscle0.81949084
90MP0005384_cellular_phenotype0.80337901
91MP0005595_abnormal_vascular_smooth0.79680084
92MP0002723_abnormal_immune_serum0.78212492
93MP0002405_respiratory_system_inflammati0.77595446
94MP0001819_abnormal_immune_cell0.77013426
95MP0002420_abnormal_adaptive_immunity0.76995855
96MP0000013_abnormal_adipose_tissue0.76613423
97MP0004233_abnormal_muscle_weight0.74822783
98MP0001845_abnormal_inflammatory_respons0.72499917
99MP0003879_abnormal_hair_cell0.72426487
100MP0004808_abnormal_hematopoietic_stem0.72208812

Predicted human phenotypes

RankGene SetZ-score
1Scanning speech (HP:0002168)3.87198435
2Dysmetric saccades (HP:0000641)3.61709798
3Protrusio acetabuli (HP:0003179)3.61213204
4Vertebral compression fractures (HP:0002953)3.27168777
5Premature rupture of membranes (HP:0001788)3.26061166
6Abnormality of liposaccharide metabolism (HP:0010968)3.05425855
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.05425855
8Abnormality of glycolipid metabolism (HP:0010969)3.05425855
9Aortic aneurysm (HP:0004942)3.03024055
10Vascular tortuosity (HP:0004948)2.87692391
11Osteolytic defects of the phalanges of the hand (HP:0009771)2.85382722
12Osteolytic defects of the hand bones (HP:0009699)2.85382722
13Cervical subluxation (HP:0003308)2.82877860
14Dysostosis multiplex (HP:0000943)2.72793945
15Arterial tortuosity (HP:0005116)2.71409884
16Distal lower limb amyotrophy (HP:0008944)2.61458449
17Eczematoid dermatitis (HP:0000976)2.60738225
18Spondylolisthesis (HP:0003302)2.55277089
19Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.46230662
20Mucopolysacchariduria (HP:0008155)2.45918912
21Urinary glycosaminoglycan excretion (HP:0003541)2.45918912
22Dilatation of the ascending aorta (HP:0005111)2.40460552
23Tetraparesis (HP:0002273)2.35841144
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35548702
25Abnormality of polysaccharide metabolism (HP:0011012)2.35548702
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35548702
27Cerebral aneurysm (HP:0004944)2.30997839
28Wormian bones (HP:0002645)2.30659253
29Aortic dissection (HP:0002647)2.29927958
30Aneurysm (HP:0002617)2.29719787
31Absent frontal sinuses (HP:0002688)2.29230621
32Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.26501769
33Increased connective tissue (HP:0009025)2.21160611
34Action tremor (HP:0002345)2.20624667
35Myocardial infarction (HP:0001658)2.20044996
36Neurofibrillary tangles (HP:0002185)2.19015569
37Postural tremor (HP:0002174)2.18623070
38Distal upper limb amyotrophy (HP:0007149)2.15449157
39Upper limb amyotrophy (HP:0009129)2.15449157
40Termporal pattern (HP:0011008)2.11531217
41Insidious onset (HP:0003587)2.11531217
42Abnormality of macrophages (HP:0004311)2.09611464
43Increased variability in muscle fiber diameter (HP:0003557)2.07384094
44Atrophic scars (HP:0001075)2.05621377
45Flat acetabular roof (HP:0003180)2.02938923
46Loss of speech (HP:0002371)2.00374105
47Abnormality of saccadic eye movements (HP:0000570)1.99560153
48Spinal rigidity (HP:0003306)1.99146767
49Nuclear cataract (HP:0100018)1.97966504
50Dysdiadochokinesis (HP:0002075)1.96217314
51Abnormality of skeletal muscle fiber size (HP:0012084)1.95745158
52Cerebral inclusion bodies (HP:0100314)1.94948186
53Truncal ataxia (HP:0002078)1.92969289
54Ankle contracture (HP:0006466)1.92856148
55Recurrent bacterial skin infections (HP:0005406)1.92465280
56Gingivitis (HP:0000230)1.91702325
57Distal lower limb muscle weakness (HP:0009053)1.91506026
58Resting tremor (HP:0002322)1.91174080
59Hand muscle atrophy (HP:0009130)1.91057522
60Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90256597
61Spinal cord lesions (HP:0100561)1.88424822
62Syringomyelia (HP:0003396)1.88424822
63Amyloidosis (HP:0011034)1.86904360
64Subacute progressive viral hepatitis (HP:0006572)1.86525461
65Mitral stenosis (HP:0001718)1.85712736
66Fragile skin (HP:0001030)1.84879446
67Recurrent abscess formation (HP:0002722)1.84518306
68Autoamputation (HP:0001218)1.83383045
69Broad face (HP:0000283)1.83175828
70Asymmetric septal hypertrophy (HP:0001670)1.82056166
71Centrally nucleated skeletal muscle fibers (HP:0003687)1.81403387
72Short nail (HP:0001799)1.81371457
73Abnormality of the frontal sinuses (HP:0002687)1.80725081
74Thin bony cortex (HP:0002753)1.80723505
75Periodontitis (HP:0000704)1.78450988
76Skin nodule (HP:0200036)1.77063751
77Mitral valve prolapse (HP:0001634)1.76898979
78Abnormality of the thoracic spine (HP:0100711)1.76201643
79Colitis (HP:0002583)1.75231659
80Thoracic kyphosis (HP:0002942)1.75166926
81Atonic seizures (HP:0010819)1.74721496
82Lower limb amyotrophy (HP:0007210)1.74422826
83Cellulitis (HP:0100658)1.73949471
84Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73330157
85Supranuclear gaze palsy (HP:0000605)1.72190157
86Obstructive sleep apnea (HP:0002870)1.71343455
87Dysmetria (HP:0001310)1.71330157
88Abnormality of dentin (HP:0010299)1.71280320
89Peritonitis (HP:0002586)1.70929237
90Emphysema (HP:0002097)1.70726380
91Systemic lupus erythematosus (HP:0002725)1.69991076
92Horizontal nystagmus (HP:0000666)1.69298279
93Genu recurvatum (HP:0002816)1.66471089
94Abnormality of the distal phalanges of the toes (HP:0010182)1.66439432
95Abnormality of the nasal mucosa (HP:0000433)1.64245179
96Interstitial pulmonary disease (HP:0006530)1.64011040
97Joint laxity (HP:0001388)1.62154947
98Upper motor neuron abnormality (HP:0002127)1.61654758
99Apathy (HP:0000741)1.60939296
100Vertebral arch anomaly (HP:0008438)1.60758989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.19974475
2CDK122.64216172
3ERN12.39896419
4RIPK12.35452459
5TRIB32.27909743
6MAP3K142.06811407
7SCYL22.06405607
8KSR21.96145478
9MST1R1.93629568
10MAP3K131.92419161
11MYLK1.88676502
12MAP3K121.88486431
13PDGFRA1.87795025
14TYK21.85982209
15JAK11.70664027
16RIPK41.68178764
17FGFR41.57259853
18TTN1.55196531
19PAK41.53844064
20IRAK31.51877188
21MAP2K31.46198428
22WNK11.43691448
23MAP3K11.42930034
24ICK1.41609278
25BLK1.40517040
26TBK11.39430237
27ZAP701.37493426
28CDK61.32522897
29TESK11.27692579
30FGFR31.26751061
31EPHB11.25412555
32MAP3K31.24375595
33PTK61.24023535
34CSK1.22750233
35CDC42BPA1.21000847
36MAP3K21.20164012
37SIK11.13876831
38MOS1.10896722
39NEK91.08677825
40SMG11.05209479
41ARAF1.05071393
42TGFBR21.04419794
43JAK31.01236841
44EEF2K1.00629101
45DDR20.99748972
46TRPM70.99643615
47GRK50.97243288
48CLK10.92210550
49PDGFRB0.92144036
50MARK20.89509945
51BRD40.89284300
52MET0.88970578
53MAP3K90.85025945
54* MTOR0.81171843
55EPHA20.80621870
56PAK20.80463690
57PTK20.78925812
58GRK60.77450220
59PDK10.75858299
60FES0.75270927
61ROCK20.73935807
62BMPR20.72274602
63IKBKE0.72257213
64STK380.71353680
65RET0.70195864
66TAOK20.69881299
67PRKG20.69632384
68RAF10.69343416
69CAMK1G0.67581936
70PDPK10.67485167
71PRKD20.67226431
72KSR10.65291434
73RPS6KA20.64238603
74SGK30.64176369
75SIK30.64081069
76LATS20.62712456
77MAPK70.62168208
78JAK20.61632307
79FGR0.60991134
80CSF1R0.60635744
81IRAK40.59929555
82MAP2K20.59442983
83NEK60.58452831
84STK100.56394657
85BTK0.54819428
86HCK0.52908070
87NTRK10.52423072
88MAP3K60.51472091
89FYN0.50461228
90PAK60.50151287
91CDK90.49164825
92IRAK20.48448434
93MAP3K80.47901979
94MARK30.47031901
95YES10.45995954
96LATS10.44834837
97MAP2K10.43192768
98TESK20.40547273
99HIPK20.38762654
100RPS6KC10.38548491

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.84177557
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03040785
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96222833
4Phosphatidylinositol signaling system_Homo sapiens_hsa040701.88787753
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.73576134
6Osteoclast differentiation_Homo sapiens_hsa043801.65826525
7Long-term potentiation_Homo sapiens_hsa047201.56092782
8Long-term depression_Homo sapiens_hsa047301.56083333
9B cell receptor signaling pathway_Homo sapiens_hsa046621.55768952
10Acute myeloid leukemia_Homo sapiens_hsa052211.54998918
11Amoebiasis_Homo sapiens_hsa051461.46330037
12Lysosome_Homo sapiens_hsa041421.45733689
13Chronic myeloid leukemia_Homo sapiens_hsa052201.45102003
14Non-small cell lung cancer_Homo sapiens_hsa052231.42013639
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.35413295
16Estrogen signaling pathway_Homo sapiens_hsa049151.27909792
17Leishmaniasis_Homo sapiens_hsa051401.27668171
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22689035
19Pancreatic cancer_Homo sapiens_hsa052121.20441459
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18970846
21Focal adhesion_Homo sapiens_hsa045101.17788285
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17315377
23mTOR signaling pathway_Homo sapiens_hsa041501.15903120
24Inositol phosphate metabolism_Homo sapiens_hsa005621.15363575
25Toxoplasmosis_Homo sapiens_hsa051451.15262901
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14553465
27GnRH signaling pathway_Homo sapiens_hsa049121.14257178
28Proteoglycans in cancer_Homo sapiens_hsa052051.10861730
29Endometrial cancer_Homo sapiens_hsa052131.10682394
30Renal cell carcinoma_Homo sapiens_hsa052111.10460709
31Hepatitis B_Homo sapiens_hsa051611.09312745
32Hepatitis C_Homo sapiens_hsa051601.06612535
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06367095
34VEGF signaling pathway_Homo sapiens_hsa043701.04635255
35Glioma_Homo sapiens_hsa052141.03974590
36Choline metabolism in cancer_Homo sapiens_hsa052311.03898979
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.03870195
38Tuberculosis_Homo sapiens_hsa051521.03631452
39Pentose phosphate pathway_Homo sapiens_hsa000301.03580161
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.00311764
41Gap junction_Homo sapiens_hsa045401.00002581
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99537258
43Renin secretion_Homo sapiens_hsa049240.99262436
44Fructose and mannose metabolism_Homo sapiens_hsa000510.98946089
45Platelet activation_Homo sapiens_hsa046110.98684512
46Thyroid cancer_Homo sapiens_hsa052160.96614646
47Apoptosis_Homo sapiens_hsa042100.96176391
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.95877740
49Adherens junction_Homo sapiens_hsa045200.95210090
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95155902
51TNF signaling pathway_Homo sapiens_hsa046680.93072955
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93007028
53African trypanosomiasis_Homo sapiens_hsa051430.92973458
54Influenza A_Homo sapiens_hsa051640.91561025
55* Endocytosis_Homo sapiens_hsa041440.88863929
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85278695
57Phagosome_Homo sapiens_hsa041450.83935901
58Staphylococcus aureus infection_Homo sapiens_hsa051500.83724762
59Prostate cancer_Homo sapiens_hsa052150.83200534
60ErbB signaling pathway_Homo sapiens_hsa040120.83064249
61Malaria_Homo sapiens_hsa051440.81865166
62Prion diseases_Homo sapiens_hsa050200.81109827
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79589556
64Sphingolipid metabolism_Homo sapiens_hsa006000.79048556
65Vibrio cholerae infection_Homo sapiens_hsa051100.76945520
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.76693397
67Small cell lung cancer_Homo sapiens_hsa052220.76681115
68Prolactin signaling pathway_Homo sapiens_hsa049170.75872147
69Shigellosis_Homo sapiens_hsa051310.74610725
70Bladder cancer_Homo sapiens_hsa052190.73610078
71T cell receptor signaling pathway_Homo sapiens_hsa046600.73474526
72Pertussis_Homo sapiens_hsa051330.72908526
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72286354
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.72276711
75Measles_Homo sapiens_hsa051620.72159176
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70269858
77ECM-receptor interaction_Homo sapiens_hsa045120.69837839
78Salivary secretion_Homo sapiens_hsa049700.66756144
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66727699
80FoxO signaling pathway_Homo sapiens_hsa040680.65955244
81Salmonella infection_Homo sapiens_hsa051320.65643887
82Renin-angiotensin system_Homo sapiens_hsa046140.65114912
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65015546
84Chemokine signaling pathway_Homo sapiens_hsa040620.64738859
85Dorso-ventral axis formation_Homo sapiens_hsa043200.64347987
86Viral myocarditis_Homo sapiens_hsa054160.63284062
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63071053
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.62665158
89Type II diabetes mellitus_Homo sapiens_hsa049300.61757690
90Colorectal cancer_Homo sapiens_hsa052100.61236234
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60795572
92Herpes simplex infection_Homo sapiens_hsa051680.60152403
93Insulin signaling pathway_Homo sapiens_hsa049100.58231334
94Pancreatic secretion_Homo sapiens_hsa049720.57879152
95HIF-1 signaling pathway_Homo sapiens_hsa040660.57724435
96Thyroid hormone synthesis_Homo sapiens_hsa049180.57433933
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54063742
98Notch signaling pathway_Homo sapiens_hsa043300.53858691
99Insulin resistance_Homo sapiens_hsa049310.50604426
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50217802

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