FAM21C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.98127295
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.51224217
3negative regulation of cell killing (GO:0031342)4.51224217
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24269814
5negative regulation of erythrocyte differentiation (GO:0045647)4.18926534
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.15247829
7antigen processing and presentation of endogenous antigen (GO:0019883)4.08435453
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.06604405
9modulation by symbiont of host immune response (GO:0052553)4.06604405
10positive regulation by symbiont of host defense response (GO:0052509)4.06604405
11modulation by symbiont of host defense response (GO:0052031)4.06604405
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06604405
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06604405
14response to peptidoglycan (GO:0032494)3.95964802
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87360983
16neutrophil activation involved in immune response (GO:0002283)3.84691740
17detection of other organism (GO:0098543)3.82069229
18response to muramyl dipeptide (GO:0032495)3.73889636
19detection of molecule of bacterial origin (GO:0032490)3.61410072
20detection of bacterium (GO:0016045)3.53937297
21regulation of gamma-delta T cell activation (GO:0046643)3.52227533
22macrophage activation involved in immune response (GO:0002281)3.46697558
23cellular extravasation (GO:0045123)3.44004740
24regulation of B cell receptor signaling pathway (GO:0050855)3.42304265
25detection of external biotic stimulus (GO:0098581)3.40373946
26negative regulation of interleukin-12 production (GO:0032695)3.32693669
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17123365
28regulation of leukocyte degranulation (GO:0043300)3.17120877
29regulation of gamma-delta T cell differentiation (GO:0045586)3.13704099
30response to laminar fluid shear stress (GO:0034616)3.07538540
31regulation of interferon-beta biosynthetic process (GO:0045357)3.06479198
32regulation of mast cell degranulation (GO:0043304)3.05791369
33antigen processing and presentation via MHC class Ib (GO:0002475)3.03912666
34mannose metabolic process (GO:0006013)3.02764757
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98018900
36detection of biotic stimulus (GO:0009595)2.96768252
37regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93875210
38histone H3-K36 demethylation (GO:0070544)2.92496163
39B cell receptor signaling pathway (GO:0050853)2.91193640
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83014409
41response to host (GO:0075136)2.83014409
42response to host defenses (GO:0052200)2.83014409
43response to host immune response (GO:0052572)2.82878920
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82878920
45protein localization to endosome (GO:0036010)2.81579847
46positive regulation of cellular amide metabolic process (GO:0034250)2.79211618
47immunoglobulin mediated immune response (GO:0016064)2.77694962
48lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77576475
49negative thymic T cell selection (GO:0045060)2.76834275
50positive regulation of B cell differentiation (GO:0045579)2.75855026
51positive thymic T cell selection (GO:0045059)2.74038715
52embryonic process involved in female pregnancy (GO:0060136)2.73914982
53regulation of T-helper 2 cell differentiation (GO:0045628)2.73884689
54regulation of mast cell activation involved in immune response (GO:0033006)2.72400061
55negative regulation of T cell mediated immunity (GO:0002710)2.71772894
56barbed-end actin filament capping (GO:0051016)2.71656132
57negative regulation of lymphocyte mediated immunity (GO:0002707)2.71144983
58pinocytosis (GO:0006907)2.70878333
59positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69178894
60regulation of B cell differentiation (GO:0045577)2.67168448
61negative regulation of leukocyte mediated immunity (GO:0002704)2.66253617
62regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62755387
63production of molecular mediator involved in inflammatory response (GO:0002532)2.60862843
64germinal center formation (GO:0002467)2.60826029
65negative T cell selection (GO:0043383)2.59678262
66myeloid cell activation involved in immune response (GO:0002275)2.59443409
67type I interferon signaling pathway (GO:0060337)2.59147092
68cellular response to type I interferon (GO:0071357)2.59147092
69neutrophil activation (GO:0042119)2.58167690
70regulation of macrophage cytokine production (GO:0010935)2.57996367
71regulation of tolerance induction (GO:0002643)2.57210686
72response to type I interferon (GO:0034340)2.57086506
73granulocyte activation (GO:0036230)2.57082465
74regulation of necroptotic process (GO:0060544)2.55311896
75leukocyte aggregation (GO:0070486)2.54657527
76regulation of T cell tolerance induction (GO:0002664)2.53906628
77negative regulation of toll-like receptor signaling pathway (GO:0034122)2.53505095
78cortical actin cytoskeleton organization (GO:0030866)2.52925295
79macrophage activation (GO:0042116)2.52537006
80hypotonic response (GO:0006971)2.52325352
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50710624
82regulation of regulated secretory pathway (GO:1903305)2.48796785
83cellular response to thyroid hormone stimulus (GO:0097067)2.48484910
84interferon-gamma-mediated signaling pathway (GO:0060333)2.45878558
85T cell selection (GO:0045058)2.44063303
86negative regulation of glycoprotein biosynthetic process (GO:0010561)2.41978900
87respiratory burst (GO:0045730)2.40931145
88positive regulation of Cdc42 GTPase activity (GO:0043089)2.39646250
89positive regulation of leukocyte degranulation (GO:0043302)2.38631931
90response to interleukin-15 (GO:0070672)2.38620443
91negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36742438
92peptide catabolic process (GO:0043171)2.35718833
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.35460027
94positive regulation of Rap GTPase activity (GO:0032854)2.35311314
95thymic T cell selection (GO:0045061)2.34580076
96stress fiber assembly (GO:0043149)2.34044642
97neutrophil mediated immunity (GO:0002446)2.33987834
98negative regulation of type 2 immune response (GO:0002829)2.33476946
99positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.31712822
100T cell migration (GO:0072678)2.30393501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.29429841
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.68012471
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65282091
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.57916685
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.11722693
6MYB_21317192_ChIP-Seq_ERMYB_Mouse3.06966202
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03778828
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01434886
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98144726
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96407622
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.61434574
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53086625
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46834827
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.44755155
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.43448839
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26610130
17SPI1_23127762_ChIP-Seq_K562_Human2.18917999
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16213423
19VDR_24763502_ChIP-Seq_THP-1_Human2.14608388
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12640718
21VDR_21846776_ChIP-Seq_THP-1_Human2.10081591
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09110943
23MYC_22102868_ChIP-Seq_BL_Human2.05417398
24TCF7_22412390_ChIP-Seq_EML_Mouse2.02964400
25RUNX_20019798_ChIP-Seq_JUKART_Human2.02960703
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96964292
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.96446916
28* SPI1_23547873_ChIP-Seq_NB4_Human1.93748256
29GATA1_22025678_ChIP-Seq_K562_Human1.93106626
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88375260
31MAF_26560356_Chip-Seq_TH1_Human1.86323378
32SCL_19346495_ChIP-Seq_HPC-7_Human1.85886635
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.85031350
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84620132
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80713879
36MYB_26560356_Chip-Seq_TH2_Human1.79168837
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72963697
38MYB_26560356_Chip-Seq_TH1_Human1.71283070
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71118429
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.70212171
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70021061
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67392278
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.65427281
44GATA1_19941826_ChIP-Seq_K562_Human1.64909815
45KDM2B_26808549_Chip-Seq_DND41_Human1.62622372
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60277310
47CLOCK_20551151_ChIP-Seq_293T_Human1.60142096
48VDR_24787735_ChIP-Seq_THP-1_Human1.59657229
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59538099
50UTX_26944678_Chip-Seq_JUKART_Human1.55314647
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55042416
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54725115
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54076658
54* TFEB_21752829_ChIP-Seq_HELA_Human1.52666217
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51253709
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49335965
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.47434726
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46975703
59PU_27001747_Chip-Seq_BMDM_Mouse1.38954692
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38508277
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30329376
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30136768
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29191334
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29062279
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28102562
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27809069
67GATA2_19941826_ChIP-Seq_K562_Human1.25846255
68MAF_26560356_Chip-Seq_TH2_Human1.23859093
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19902150
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18444657
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18107831
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.16628473
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16486670
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15047109
75GATA3_27048872_Chip-Seq_THYMUS_Human1.14131769
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12583655
77NCOR1_26117541_ChIP-Seq_K562_Human1.11068873
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08909463
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06734917
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06706829
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06140764
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06140764
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.05738327
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04408267
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.04152263
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03234987
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02379195
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00633797
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00481354
90LXR_22292898_ChIP-Seq_THP-1_Human0.99542724
91TBX20_22080862_ChIP-Seq_HEART_Mouse0.98860018
92TBX20_22328084_ChIP-Seq_HEART_Mouse0.98860018
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98482145
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97745704
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95368929
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95028774
97KDM2B_26808549_Chip-Seq_K562_Human0.93530655
98RACK7_27058665_Chip-Seq_MCF-7_Human0.92284310
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91809693
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.90398372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.20094129
2MP0005058_abnormal_lysosome_morphology3.16639703
3MP0003172_abnormal_lysosome_physiology3.01715946
4MP0003303_peritoneal_inflammation3.00710482
5MP0003300_gastrointestinal_ulcer2.98485935
6MP0001835_abnormal_antigen_presentation2.92124017
7MP0003724_increased_susceptibility_to2.91744418
8MP0003191_abnormal_cellular_cholesterol2.44927791
9MP0002419_abnormal_innate_immunity2.33421425
10MP0005451_abnormal_body_composition2.22921620
11MP0003828_pulmonary_edema2.17899170
12MP0000685_abnormal_immune_system2.13326338
13MP0008260_abnormal_autophagy2.13213121
14MP0003656_abnormal_erythrocyte_physiolo2.08310090
15MP0006082_CNS_inflammation2.06217635
16MP0005000_abnormal_immune_tolerance2.05365015
17MP0005025_abnormal_response_to1.97164686
18MP0003763_abnormal_thymus_physiology1.96550989
19MP0001800_abnormal_humoral_immune1.95537220
20MP0003705_abnormal_hypodermis_morpholog1.93618480
21MP0005464_abnormal_platelet_physiology1.90505550
22MP0001790_abnormal_immune_system1.84124699
23MP0005387_immune_system_phenotype1.84124699
24MP0002452_abnormal_antigen_presenting1.84073774
25MP0004947_skin_inflammation1.83261241
26MP0003091_abnormal_cell_migration1.82110196
27MP0009785_altered_susceptibility_to1.77257486
28MP0002723_abnormal_immune_serum1.76292115
29MP0002420_abnormal_adaptive_immunity1.73624371
30MP0001533_abnormal_skeleton_physiology1.73246523
31MP0001819_abnormal_immune_cell1.72275911
32MP0002166_altered_tumor_susceptibility1.71779178
33MP0002009_preneoplasia1.68366394
34MP0008438_abnormal_cutaneous_collagen1.66870120
35MP0009840_abnormal_foam_cell1.65722125
36MP0003566_abnormal_cell_adhesion1.61622474
37MP0010352_gastrointestinal_tract_polyps1.60413194
38MP0002998_abnormal_bone_remodeling1.56999396
39MP0005671_abnormal_response_to1.55517045
40MP0010155_abnormal_intestine_physiology1.55305733
41MP0002877_abnormal_melanocyte_morpholog1.50498810
42MP0002148_abnormal_hypersensitivity_rea1.48575291
43MP0008004_abnormal_stomach_pH1.48079663
44MP0005076_abnormal_cell_differentiation1.47199380
45MP0000465_gastrointestinal_hemorrhage1.46903233
46MP0002405_respiratory_system_inflammati1.44508179
47MP0002396_abnormal_hematopoietic_system1.43196083
48MP0002398_abnormal_bone_marrow1.42712204
49MP0000858_altered_metastatic_potential1.39246604
50MP0009278_abnormal_bone_marrow1.34549427
51MP0001845_abnormal_inflammatory_respons1.30637427
52MP0000716_abnormal_immune_system1.29637951
53MP0003183_abnormal_peptide_metabolism1.28098290
54MP0005397_hematopoietic_system_phenotyp1.27685739
55MP0001545_abnormal_hematopoietic_system1.27685739
56MP0010234_abnormal_vibrissa_follicle1.26236591
57MP0000604_amyloidosis1.25716740
58MP0001853_heart_inflammation1.25131651
59MP0001851_eye_inflammation1.25045012
60MP0003690_abnormal_glial_cell1.22912231
61MP0003866_abnormal_defecation1.22713840
62MP0002722_abnormal_immune_system1.19688135
63MP0003279_aneurysm1.18535984
64MP0000689_abnormal_spleen_morphology1.16858684
65MP0004808_abnormal_hematopoietic_stem1.16398385
66MP0003448_altered_tumor_morphology1.16021554
67MP0004510_myositis1.14046837
68MP0001958_emphysema1.12944272
69MP0005164_abnormal_response_to1.08754147
70MP0002429_abnormal_blood_cell1.08509701
71MP0006054_spinal_hemorrhage1.07309624
72MP0002006_tumorigenesis1.06094299
73MP0003453_abnormal_keratinocyte_physiol1.05496597
74MP0008469_abnormal_protein_level1.05204236
75MP0000703_abnormal_thymus_morphology1.04507802
76MP0004883_abnormal_blood_vessel1.00254368
77MP0009333_abnormal_splenocyte_physiolog0.99724452
78MP0003045_fibrosis0.99052844
79MP0005310_abnormal_salivary_gland0.97688276
80MP0003075_altered_response_to0.97223760
81MP0001542_abnormal_bone_strength0.94988213
82MP0005621_abnormal_cell_physiology0.94528383
83MP0005409_darkened_coat_color0.92019097
84MP0005166_decreased_susceptibility_to0.89949842
85MP0000343_altered_response_to0.89738691
86MP0003795_abnormal_bone_structure0.89042917
87MP0003221_abnormal_cardiomyocyte_apopto0.87007644
88MP0005023_abnormal_wound_healing0.84678996
89MP0000767_abnormal_smooth_muscle0.84091464
90MP0005390_skeleton_phenotype0.83157173
91MP0002254_reproductive_system_inflammat0.81070691
92MP0005275_abnormal_skin_tensile0.80222534
93MP0001915_intracranial_hemorrhage0.78847576
94MP0000569_abnormal_digit_pigmentation0.78343541
95MP0001849_ear_inflammation0.77134556
96MP0009764_decreased_sensitivity_to0.73647291
97MP0000015_abnormal_ear_pigmentation0.73172425
98MP0009763_increased_sensitivity_to0.73166476
99MP0000249_abnormal_blood_vessel0.73113302
100MP0002060_abnormal_skin_morphology0.72807918

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.53582161
2Recurrent bacterial skin infections (HP:0005406)3.77881443
3Recurrent abscess formation (HP:0002722)3.68868184
4Abnormality of macrophages (HP:0004311)3.63683989
5Abnormality of liposaccharide metabolism (HP:0010968)3.29285007
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.29285007
7Abnormality of glycolipid metabolism (HP:0010969)3.29285007
8Recurrent gram-negative bacterial infections (HP:0005420)3.05434714
9Dysostosis multiplex (HP:0000943)2.95045920
10Spontaneous hematomas (HP:0007420)2.91363245
11Gingivitis (HP:0000230)2.82535618
12Myositis (HP:0100614)2.75372063
13Cellulitis (HP:0100658)2.64513274
14Orchitis (HP:0100796)2.61088757
15Spondylolisthesis (HP:0003302)2.48367685
16Hematochezia (HP:0002573)2.46839541
17Gastrointestinal infarctions (HP:0005244)2.46741098
18Vertebral compression fractures (HP:0002953)2.46245990
19Urinary glycosaminoglycan excretion (HP:0003541)2.45149054
20Mucopolysacchariduria (HP:0008155)2.45149054
21Recurrent skin infections (HP:0001581)2.42357145
22Colitis (HP:0002583)2.42230722
23Prolonged bleeding time (HP:0003010)2.41846031
24Mediastinal lymphadenopathy (HP:0100721)2.41712066
25Protrusio acetabuli (HP:0003179)2.40930910
26Increased IgE level (HP:0003212)2.39999631
27Recurrent fungal infections (HP:0002841)2.38742096
28Retrobulbar optic neuritis (HP:0100654)2.36081782
29Optic neuritis (HP:0100653)2.36081782
30Osteomyelitis (HP:0002754)2.35946165
31Abnormality of polysaccharide metabolism (HP:0011012)2.35407644
32Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35407644
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35407644
34Inflammation of the large intestine (HP:0002037)2.31919478
35Gastrointestinal inflammation (HP:0004386)2.30536099
36Aortic aneurysm (HP:0004942)2.28592230
37Amyloidosis (HP:0011034)2.28352169
38Gingival bleeding (HP:0000225)2.25845321
39Dilatation of the ascending aorta (HP:0005111)2.24838645
40Recurrent viral infections (HP:0004429)2.24475400
41T lymphocytopenia (HP:0005403)2.23830671
42Systemic lupus erythematosus (HP:0002725)2.23683663
43Loss of speech (HP:0002371)2.23033572
44Recurrent cutaneous fungal infections (HP:0011370)2.22793494
45Chronic mucocutaneous candidiasis (HP:0002728)2.22793494
46Osteolytic defects of the hand bones (HP:0009699)2.22364455
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.22364455
48Increased cerebral lipofuscin (HP:0011813)2.22013719
49Peritonitis (HP:0002586)2.20752095
50Myocardial infarction (HP:0001658)2.20375426
51Elevated erythrocyte sedimentation rate (HP:0003565)2.18038914
52Vacuolated lymphocytes (HP:0001922)2.16010146
53Pustule (HP:0200039)2.13739241
54Meningitis (HP:0001287)2.13443599
55Vasculitis (HP:0002633)2.10851780
56Obstructive lung disease (HP:0006536)2.10516729
57Chronic obstructive pulmonary disease (HP:0006510)2.10516729
58Pulmonary infiltrates (HP:0002113)2.08284219
59Epistaxis (HP:0000421)2.07869993
60Stomatitis (HP:0010280)2.07728355
61Cerebral aneurysm (HP:0004944)2.06170620
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.06117711
63Aneurysm (HP:0002617)2.00406425
64Urticaria (HP:0001025)1.99911836
65Abnormal platelet volume (HP:0011876)1.99737141
66Chest pain (HP:0100749)1.99101197
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98002718
68Thoracic kyphosis (HP:0002942)1.97554540
69Abnormality of T cell number (HP:0011839)1.96742612
70Polycythemia (HP:0001901)1.94678457
71Increased connective tissue (HP:0009025)1.94491564
72Premature rupture of membranes (HP:0001788)1.94174618
73Petechiae (HP:0000967)1.92264025
74Fatigue (HP:0012378)1.90573926
75Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90299021
76Scanning speech (HP:0002168)1.89726541
77Vascular tortuosity (HP:0004948)1.89005953
78Arterial tortuosity (HP:0005116)1.85510788
79Arterial thrombosis (HP:0004420)1.85250587
80Spinal cord lesions (HP:0100561)1.84637987
81Syringomyelia (HP:0003396)1.84637987
82Abnormality of the fingertips (HP:0001211)1.84514966
83Subacute progressive viral hepatitis (HP:0006572)1.83747346
84Abnormality of the peritoneum (HP:0002585)1.83565292
85Interstitial pulmonary disease (HP:0006530)1.83449453
86Viral hepatitis (HP:0006562)1.83057230
87Slow saccadic eye movements (HP:0000514)1.82432373
88Periodontitis (HP:0000704)1.80605919
89Cervical subluxation (HP:0003308)1.78282240
90Distal lower limb amyotrophy (HP:0008944)1.78281030
91Hemoptysis (HP:0002105)1.78246042
92Asymmetric septal hypertrophy (HP:0001670)1.78213013
93Increased variability in muscle fiber diameter (HP:0003557)1.77672933
94Purpura (HP:0000979)1.77275826
95Abnormality of skeletal muscle fiber size (HP:0012084)1.75535799
96Abnormality of the thoracic spine (HP:0100711)1.73371119
97Aortic dissection (HP:0002647)1.72420682
98Keratoconjunctivitis sicca (HP:0001097)1.72329407
99Emphysema (HP:0002097)1.70819722
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.70573670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.78899346
2RIPK43.21182934
3TYK22.69658086
4MAP3K142.49523450
5BLK2.43471715
6ERN12.43116366
7CDK122.27019862
8MAP2K32.25378178
9MAP4K12.09990458
10MAP3K132.05711177
11JAK12.02809365
12ZAP701.98397339
13CSK1.83896085
14IRAK41.75740959
15JAK31.68090722
16FGFR41.67096334
17EPHB11.65849367
18TRIB31.65469877
19FES1.58740071
20TBK11.57481435
21RIPK11.51446459
22MAP3K11.49873741
23IKBKE1.44430054
24FGFR31.34434935
25BTK1.34303061
26MAP3K31.29442950
27KSR21.23757889
28TGFBR21.22955875
29FGR1.16026335
30IRAK31.15869292
31GRK61.15740275
32BMPR21.15395698
33HCK1.14491030
34BRD41.13820763
35SYK1.07341480
36TTN1.07278832
37PRKD21.06412713
38JAK21.05309102
39CDC42BPA1.04932649
40PDGFRA1.03699088
41NEK91.03062174
42CDK61.03036093
43TAOK21.01758352
44CSF1R0.99144542
45KIT0.98366381
46STK100.93673710
47ICK0.93023853
48MAP3K60.92738948
49MARK20.92032044
50MARK30.91247020
51YES10.88156228
52TRPM70.85049922
53MOS0.84583343
54SIK30.84215232
55WNK10.83170369
56LCK0.83111059
57NLK0.83088172
58LYN0.81752818
59TEC0.81488043
60STK380.80115140
61TAOK10.79403753
62PDGFRB0.78485219
63RET0.77656744
64EPHA30.76675360
65IKBKB0.76460723
66PDK10.76015771
67MAPK70.75308196
68SGK30.74741728
69ITK0.74252610
70MAP3K100.73124291
71SIK10.72434691
72PTK60.71852069
73MAP3K20.71518575
74IRAK20.71237232
75HIPK20.69249212
76PDPK10.69084895
77SMG10.69057262
78IRAK10.68723775
79MTOR0.67034380
80TNK20.66161601
81CAMK1D0.64178225
82CDK40.63478646
83TXK0.63403461
84MAP3K50.63333950
85SCYL20.62810556
86MAP3K70.58912790
87MELK0.55029605
88DDR20.53083746
89CAMK1G0.52648946
90MAP2K20.52462828
91PIK3CG0.50842526
92CLK10.49958881
93FYN0.49597767
94LRRK20.48388199
95RPS6KL10.46376369
96RPS6KC10.46376369
97MAPK110.46124583
98PAK40.45400531
99MYLK0.44679470
100DYRK1B0.44199073

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.90478284
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.56624582
3Osteoclast differentiation_Homo sapiens_hsa043802.34119530
4Leishmaniasis_Homo sapiens_hsa051402.23848246
5B cell receptor signaling pathway_Homo sapiens_hsa046622.08032321
6Staphylococcus aureus infection_Homo sapiens_hsa051501.85963912
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73794361
8Acute myeloid leukemia_Homo sapiens_hsa052211.69797361
9Tuberculosis_Homo sapiens_hsa051521.64705712
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52677885
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.51971777
12Toxoplasmosis_Homo sapiens_hsa051451.50559866
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.50462152
14Non-small cell lung cancer_Homo sapiens_hsa052231.47038140
15Chronic myeloid leukemia_Homo sapiens_hsa052201.46920251
16Lysosome_Homo sapiens_hsa041421.41914008
17Malaria_Homo sapiens_hsa051441.37633472
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37322866
19Allograft rejection_Homo sapiens_hsa053301.37277425
20Measles_Homo sapiens_hsa051621.35884875
21Influenza A_Homo sapiens_hsa051641.35515940
22Graft-versus-host disease_Homo sapiens_hsa053321.35160616
23Hepatitis B_Homo sapiens_hsa051611.33146302
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.32623632
25T cell receptor signaling pathway_Homo sapiens_hsa046601.31514292
26Pancreatic cancer_Homo sapiens_hsa052121.30531654
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27528743
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27358907
29TNF signaling pathway_Homo sapiens_hsa046681.26911815
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26091596
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23394136
32Autoimmune thyroid disease_Homo sapiens_hsa053201.22745573
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21315844
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19613148
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18297166
36Herpes simplex infection_Homo sapiens_hsa051681.17820730
37Viral myocarditis_Homo sapiens_hsa054161.17059766
38Hepatitis C_Homo sapiens_hsa051601.15072234
39Platelet activation_Homo sapiens_hsa046111.14438970
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14101714
41Phagosome_Homo sapiens_hsa041451.13106370
42Chemokine signaling pathway_Homo sapiens_hsa040621.11601071
43Antigen processing and presentation_Homo sapiens_hsa046121.11100489
44Hematopoietic cell lineage_Homo sapiens_hsa046401.08415924
45Apoptosis_Homo sapiens_hsa042101.07640769
46Amoebiasis_Homo sapiens_hsa051461.06442832
47Type I diabetes mellitus_Homo sapiens_hsa049401.06073503
48Legionellosis_Homo sapiens_hsa051341.06071185
49Renal cell carcinoma_Homo sapiens_hsa052111.05629734
50Endometrial cancer_Homo sapiens_hsa052131.05274018
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.04689812
52mTOR signaling pathway_Homo sapiens_hsa041501.04028918
53Pertussis_Homo sapiens_hsa051331.01428522
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.00572790
55Shigellosis_Homo sapiens_hsa051310.99073137
56VEGF signaling pathway_Homo sapiens_hsa043700.96426344
57Prolactin signaling pathway_Homo sapiens_hsa049170.95261023
58Inositol phosphate metabolism_Homo sapiens_hsa005620.92746613
59Primary immunodeficiency_Homo sapiens_hsa053400.92475452
60Prostate cancer_Homo sapiens_hsa052150.87968748
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.86744689
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86264420
63Choline metabolism in cancer_Homo sapiens_hsa052310.86159692
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.85674047
65African trypanosomiasis_Homo sapiens_hsa051430.85632095
66* Endocytosis_Homo sapiens_hsa041440.85514773
67GnRH signaling pathway_Homo sapiens_hsa049120.84556461
68Salmonella infection_Homo sapiens_hsa051320.83306901
69FoxO signaling pathway_Homo sapiens_hsa040680.81712921
70Thyroid cancer_Homo sapiens_hsa052160.81158950
71Asthma_Homo sapiens_hsa053100.77718943
72Glioma_Homo sapiens_hsa052140.77652165
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.77018205
74Rheumatoid arthritis_Homo sapiens_hsa053230.75514277
75Focal adhesion_Homo sapiens_hsa045100.75303616
76Proteoglycans in cancer_Homo sapiens_hsa052050.74107320
77Long-term potentiation_Homo sapiens_hsa047200.71203740
78Estrogen signaling pathway_Homo sapiens_hsa049150.69751402
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67913684
80Dorso-ventral axis formation_Homo sapiens_hsa043200.67763113
81Notch signaling pathway_Homo sapiens_hsa043300.66725447
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.66202128
83Small cell lung cancer_Homo sapiens_hsa052220.65712469
84Insulin resistance_Homo sapiens_hsa049310.65584359
85HIF-1 signaling pathway_Homo sapiens_hsa040660.65156497
86Colorectal cancer_Homo sapiens_hsa052100.64485777
87ErbB signaling pathway_Homo sapiens_hsa040120.63639120
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62563931
89Type II diabetes mellitus_Homo sapiens_hsa049300.60867389
90Bladder cancer_Homo sapiens_hsa052190.60418538
91Viral carcinogenesis_Homo sapiens_hsa052030.59985943
92HTLV-I infection_Homo sapiens_hsa051660.58903330
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57146068
94Insulin signaling pathway_Homo sapiens_hsa049100.56869390
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56822561
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55682858
97Adherens junction_Homo sapiens_hsa045200.53778789
98Epstein-Barr virus infection_Homo sapiens_hsa051690.52775815
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51570294
100Prion diseases_Homo sapiens_hsa050200.51542641

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »