ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of 5.8S rRNA (GO:0000460)	5.45925260
2	negative regulation of telomere maintenance (GO:0032205)	5.04677111
3	DNA deamination (GO:0045006)	4.93352321
4	platelet dense granule organization (GO:0060155)	4.60281356
5	nucleotide transmembrane transport (GO:1901679)	4.44919586
6	negative regulation of protein oligomerization (GO:0032460)	4.38702273
7	behavioral response to nicotine (GO:0035095)	4.25774645
8	protein import into peroxisome matrix (GO:0016558)	4.25026810
9	protein-cofactor linkage (GO:0018065)	4.21347258
10	L-fucose catabolic process (GO:0042355)	4.04391136
11	fucose catabolic process (GO:0019317)	4.04391136
12	L-fucose metabolic process (GO:0042354)	4.04391136
13	response to pheromone (GO:0019236)	3.63722501
14	axoneme assembly (GO:0035082)	3.60454459
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.60005305
16	piRNA metabolic process (GO:0034587)	3.50062395
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.43263965
18	preassembly of GPI anchor in ER membrane (GO:0016254)	3.42225185
19	mannosylation (GO:0097502)	3.41075760
20	rRNA catabolic process (GO:0016075)	3.38876050
21	ubiquinone biosynthetic process (GO:0006744)	3.32142861
22	epithelial cilium movement (GO:0003351)	3.26857334
23	ubiquinone metabolic process (GO:0006743)	3.25685398
24	protein polyglutamylation (GO:0018095)	3.18976307
25	regulation of cilium movement (GO:0003352)	3.17564098
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12304294
27	regulation of telomere maintenance (GO:0032204)	3.07818194
28	protein targeting to peroxisome (GO:0006625)	3.06402725
29	establishment of protein localization to peroxisome (GO:0072663)	3.06402725
30	protein localization to peroxisome (GO:0072662)	3.06402725
31	DNA double-strand break processing (GO:0000729)	3.06350090
32	indole-containing compound catabolic process (GO:0042436)	3.05386320
33	indolalkylamine catabolic process (GO:0046218)	3.05386320
34	tryptophan catabolic process (GO:0006569)	3.05386320
35	protein complex biogenesis (GO:0070271)	3.02755535
36	NADH dehydrogenase complex assembly (GO:0010257)	3.02204892
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.02204892
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.02204892
39	indolalkylamine metabolic process (GO:0006586)	3.01799846
40	detection of light stimulus involved in visual perception (GO:0050908)	3.00556432
41	detection of light stimulus involved in sensory perception (GO:0050962)	3.00556432
42	adaptation of signaling pathway (GO:0023058)	2.99704157
43	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98863615
44	respiratory chain complex IV assembly (GO:0008535)	2.98038305
45	protein localization to cilium (GO:0061512)	2.96230025
46	negative regulation of mast cell activation (GO:0033004)	2.93789552
47	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.92168177
48	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.89481925
49	sulfation (GO:0051923)	2.86143028
50	cellular ketone body metabolic process (GO:0046950)	2.81796305
51	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.81334803
52	gamma-aminobutyric acid transport (GO:0015812)	2.80013701
53	GPI anchor metabolic process (GO:0006505)	2.77981125
54	S-adenosylmethionine metabolic process (GO:0046500)	2.74538959
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.73219133
56	ketone body metabolic process (GO:1902224)	2.70290913
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.69917403
58	cytochrome complex assembly (GO:0017004)	2.68565628
59	quinone biosynthetic process (GO:1901663)	2.68513374
60	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.67371812
61	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.67371812
62	kynurenine metabolic process (GO:0070189)	2.66670628
63	cornea development in camera-type eye (GO:0061303)	2.66178203
64	L-methionine salvage (GO:0071267)	2.65208269
65	L-methionine biosynthetic process (GO:0071265)	2.65208269
66	amino acid salvage (GO:0043102)	2.65208269
67	adenosine metabolic process (GO:0046085)	2.65031007
68	peroxisome organization (GO:0007031)	2.64885049
69	protein K11-linked deubiquitination (GO:0035871)	2.63739975
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.63169280
71	inositol phosphate catabolic process (GO:0071545)	2.62508239
72	tryptophan metabolic process (GO:0006568)	2.61306278
73	cilium movement (GO:0003341)	2.60381848
74	iron-sulfur cluster assembly (GO:0016226)	2.60158966
75	metallo-sulfur cluster assembly (GO:0031163)	2.60158966
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.59759366
77	regulation of hexokinase activity (GO:1903299)	2.59371712
78	regulation of glucokinase activity (GO:0033131)	2.59371712
79	cilium morphogenesis (GO:0060271)	2.58419521
80	DNA methylation involved in gamete generation (GO:0043046)	2.58302314
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.57985377
82	dopamine transport (GO:0015872)	2.56924757
83	photoreceptor cell maintenance (GO:0045494)	2.56754673
84	peroxisomal transport (GO:0043574)	2.55829914
85	lipopolysaccharide biosynthetic process (GO:0009103)	2.53268895
86	intracellular protein transmembrane import (GO:0044743)	2.53034862
87	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.52809988
88	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.52125874
89	regulation of mitotic spindle checkpoint (GO:1903504)	2.52125874
90	pyrimidine nucleobase catabolic process (GO:0006208)	2.50861291
91	positive regulation of mitochondrial fission (GO:0090141)	2.49087216
92	sleep (GO:0030431)	2.47252791
93	glycerophospholipid catabolic process (GO:0046475)	2.47029863
94	nonmotile primary cilium assembly (GO:0035058)	2.45789232
95	rhodopsin mediated signaling pathway (GO:0016056)	2.44782353
96	auditory receptor cell stereocilium organization (GO:0060088)	2.41878202
97	GPI anchor biosynthetic process (GO:0006506)	2.41723586
98	C-terminal protein amino acid modification (GO:0018410)	2.40548566
99	multicellular organism reproduction (GO:0032504)	2.40548256
100	C-terminal protein lipidation (GO:0006501)	2.39343638

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.06432476
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.43897248
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.98228698
4	VDR_22108803_ChIP-Seq_LS180_Human	2.88097704
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.74025265
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51899261
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.36780126
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.34215989
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30149249
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28175042
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.26305688
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23355390
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.21344524
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20054939
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04696148
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04201163
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.94955409
18	EWS_26573619_Chip-Seq_HEK293_Human	1.94307399
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90805275
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89143282
21	FUS_26573619_Chip-Seq_HEK293_Human	1.87230723
22	P300_19829295_ChIP-Seq_ESCs_Human	1.83139566
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76127767
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.75188562
25	EZH2_22144423_ChIP-Seq_EOC_Human	1.73533783
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73476256
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69703223
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.66879763
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.66173094
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65248918
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.61715062
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.60459174
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57700416
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.57700416
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.53854972
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.50224713
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45635946
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45635946
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.43826329
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40466107
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38356105
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38356105
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.37426408
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36910731
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35583374
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32579524
47	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.31659458
48	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.31289987
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29013634
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28379784
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27932849
52	NCOR_22424771_ChIP-Seq_293T_Human	1.27564232
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25538996
54	AR_20517297_ChIP-Seq_VCAP_Human	1.24154974
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23507688
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23483252
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23043862
58	STAT3_23295773_ChIP-Seq_U87_Human	1.22132767
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22090057
60	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.21259771
61	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21175960
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.20925186
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20906485
64	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.20127511
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19738433
66	AR_25329375_ChIP-Seq_VCAP_Human	1.18305418
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18257924
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17984479
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.17053613
70	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16660156
71	TCF4_23295773_ChIP-Seq_U87_Human	1.16330222
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16039673
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15371843
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14511199
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14150527
76	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10976499
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.10049585
78	FOXP3_21729870_ChIP-Seq_TREG_Human	1.09003387
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08876995
80	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08366240
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08313234
82	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.07326073
83	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05792801
84	GATA3_26560356_Chip-Seq_TH2_Human	1.05766063
85	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03661606
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.03034208
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02883372
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02481253
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01756942
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.01704609
91	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01627815
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01208728
93	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00810582
94	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00719655
95	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00064123
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99108640
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97924125
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97825451
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.96939854
100	ERA_21632823_ChIP-Seq_H3396_Human	0.96244963

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.29364549
2	MP0002837_dystrophic_cardiac_calcinosis	2.95598759
3	MP0003195_calcinosis	2.93843998
4	MP0002254_reproductive_system_inflammat	2.76887268
5	MP0006072_abnormal_retinal_apoptosis	2.67112525
6	MP0002876_abnormal_thyroid_physiology	2.60966244
7	MP0001984_abnormal_olfaction	2.41651165
8	MP0001986_abnormal_taste_sensitivity	2.41380005
9	MP0006082_CNS_inflammation	2.35485682
10	MP0008877_abnormal_DNA_methylation	2.34955760
11	MP0005551_abnormal_eye_electrophysiolog	2.13846146
12	MP0003880_abnormal_central_pattern	2.05849591
13	MP0001968_abnormal_touch/_nociception	2.05750318
14	MP0000372_irregular_coat_pigmentation	1.99126274
15	MP0005253_abnormal_eye_physiology	1.97570373
16	MP0009046_muscle_twitch	1.93421027
17	MP0008872_abnormal_physiological_respon	1.90965523
18	MP0005646_abnormal_pituitary_gland	1.77194250
19	MP0005645_abnormal_hypothalamus_physiol	1.75511995
20	MP0009745_abnormal_behavioral_response	1.68078659
21	MP0003011_delayed_dark_adaptation	1.65995103
22	MP0008875_abnormal_xenobiotic_pharmacok	1.65387328
23	MP0006276_abnormal_autonomic_nervous	1.64063173
24	MP0001501_abnormal_sleep_pattern	1.62547969
25	MP0002272_abnormal_nervous_system	1.60914991
26	MP0004043_abnormal_pH_regulation	1.60654537
27	MP0004885_abnormal_endolymph	1.60008777
28	MP0002736_abnormal_nociception_after	1.56071866
29	MP0005084_abnormal_gallbladder_morpholo	1.54843164
30	MP0010386_abnormal_urinary_bladder	1.52600739
31	MP0002638_abnormal_pupillary_reflex	1.47513582
32	MP0002163_abnormal_gland_morphology	1.45242526
33	MP0004142_abnormal_muscle_tone	1.43187807
34	MP0001919_abnormal_reproductive_system	1.40426466
35	MP0004147_increased_porphyrin_level	1.40235921
36	MP0005389_reproductive_system_phenotype	1.35097738
37	MP0005075_abnormal_melanosome_morpholog	1.33975187
38	MP0002138_abnormal_hepatobiliary_system	1.32013365
39	MP0003787_abnormal_imprinting	1.31913354
40	MP0001529_abnormal_vocalization	1.31048528
41	MP0000631_abnormal_neuroendocrine_gland	1.30150332
42	MP0002132_abnormal_respiratory_system	1.28081543
43	MP0001905_abnormal_dopamine_level	1.27065762
44	MP0000427_abnormal_hair_cycle	1.26991295
45	MP0005167_abnormal_blood-brain_barrier	1.26661818
46	MP0004133_heterotaxia	1.24921269
47	MP0005379_endocrine/exocrine_gland_phen	1.23705064
48	MP0003136_yellow_coat_color	1.21492891
49	MP0002277_abnormal_respiratory_mucosa	1.21463111
50	MP0005410_abnormal_fertilization	1.20851819
51	MP0008058_abnormal_DNA_repair	1.19707693
52	MP0005671_abnormal_response_to	1.18432731
53	MP0001764_abnormal_homeostasis	1.16492063
54	MP0002160_abnormal_reproductive_system	1.16220677
55	MP0001486_abnormal_startle_reflex	1.16076022
56	MP0005083_abnormal_biliary_tract	1.15423238
57	MP0008995_early_reproductive_senescence	1.13092491
58	MP0002693_abnormal_pancreas_physiology	1.07757360
59	MP0002653_abnormal_ependyma_morphology	1.07676234
60	MP0002572_abnormal_emotion/affect_behav	1.07331235
61	MP0003724_increased_susceptibility_to	1.07091923
62	MP0002751_abnormal_autonomic_nervous	1.05625391
63	MP0001873_stomach_inflammation	1.04994397
64	MP0005174_abnormal_tail_pigmentation	1.02999223
65	MP0002064_seizures	1.00579706
66	MP0002557_abnormal_social/conspecific_i	0.98779939
67	MP0000230_abnormal_systemic_arterial	0.98551964
68	MP0003252_abnormal_bile_duct	0.98105661
69	MP0005367_renal/urinary_system_phenotyp	0.97226938
70	MP0000516_abnormal_urinary_system	0.97226938
71	MP0001485_abnormal_pinna_reflex	0.97105390
72	MP0005085_abnormal_gallbladder_physiolo	0.97037352
73	MP0006292_abnormal_olfactory_placode	0.96832669
74	MP0003698_abnormal_male_reproductive	0.95905586
75	MP0001970_abnormal_pain_threshold	0.94546847
76	MP0010329_abnormal_lipoprotein_level	0.92383979
77	MP0001188_hyperpigmentation	0.91883786
78	MP0004924_abnormal_behavior	0.91761123
79	MP0005386_behavior/neurological_phenoty	0.91761123
80	MP0002928_abnormal_bile_duct	0.89803908
81	MP0003137_abnormal_impulse_conducting	0.89256851
82	MP0003718_maternal_effect	0.88522716
83	MP0001929_abnormal_gametogenesis	0.87170799
84	MP0002733_abnormal_thermal_nociception	0.83322961
85	MP0008775_abnormal_heart_ventricle	0.82974423
86	MP0008789_abnormal_olfactory_epithelium	0.82268648
87	MP0002067_abnormal_sensory_capabilities	0.82121633
88	MP0004215_abnormal_myocardial_fiber	0.80731467
89	MP0003786_premature_aging	0.80522525
90	MP0005195_abnormal_posterior_eye	0.80213021
91	MP0005647_abnormal_sex_gland	0.80032108
92	MP0005220_abnormal_exocrine_pancreas	0.78989848
93	MP0004145_abnormal_muscle_electrophysio	0.78146272
94	MP0001502_abnormal_circadian_rhythm	0.78014318
95	MP0003635_abnormal_synaptic_transmissio	0.77832811
96	MP0002234_abnormal_pharynx_morphology	0.76748714
97	MP0001944_abnormal_pancreas_morphology	0.76512075
98	MP0000015_abnormal_ear_pigmentation	0.76395562
99	MP0000383_abnormal_hair_follicle	0.75702507
100	MP0002938_white_spotting	0.73968409

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.31880721
2	Pancreatic cysts (HP:0001737)	4.09610144
3	Pancreatic fibrosis (HP:0100732)	3.75504420
4	True hermaphroditism (HP:0010459)	3.75269590
5	Abnormality of midbrain morphology (HP:0002418)	3.29059102
6	Molar tooth sign on MRI (HP:0002419)	3.29059102
7	Cerebellar dysplasia (HP:0007033)	3.07811372
8	Polydipsia (HP:0001959)	3.06369507
9	Abnormal drinking behavior (HP:0030082)	3.06369507
10	Nephronophthisis (HP:0000090)	3.05663602
11	Abnormality of the renal cortex (HP:0011035)	2.95644839
12	Medial flaring of the eyebrow (HP:0010747)	2.90305721
13	Attenuation of retinal blood vessels (HP:0007843)	2.89160804
14	Congenital stationary night blindness (HP:0007642)	2.86640825
15	Methylmalonic acidemia (HP:0002912)	2.78292744
16	Acute necrotizing encephalopathy (HP:0006965)	2.76422207
17	Hypothermia (HP:0002045)	2.70738651
18	Progressive macrocephaly (HP:0004481)	2.70515932
19	Stomach cancer (HP:0012126)	2.69938762
20	Mitochondrial inheritance (HP:0001427)	2.68598277
21	Increased CSF lactate (HP:0002490)	2.66427081
22	Pendular nystagmus (HP:0012043)	2.60909009
23	Stomatitis (HP:0010280)	2.60863799
24	Hepatocellular necrosis (HP:0001404)	2.59571342
25	Abnormality of the renal medulla (HP:0100957)	2.59465972
26	Brushfield spots (HP:0001088)	2.58307910
27	Abolished electroretinogram (ERG) (HP:0000550)	2.54103897
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.53994037
29	Renal cortical cysts (HP:0000803)	2.51693293
30	Hypomagnesemia (HP:0002917)	2.48678433
31	Cystic liver disease (HP:0006706)	2.47442484
32	Hepatic necrosis (HP:0002605)	2.46320624
33	Polyuria (HP:0000103)	2.45241030
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.41515424
35	Tubular atrophy (HP:0000092)	2.38010940
36	Acute encephalopathy (HP:0006846)	2.35841098
37	Lissencephaly (HP:0001339)	2.35416805
38	Methylmalonic aciduria (HP:0012120)	2.35087088
39	3-Methylglutaconic aciduria (HP:0003535)	2.34431151
40	Inability to walk (HP:0002540)	2.31457965
41	Chronic hepatic failure (HP:0100626)	2.28402741
42	Keratoconus (HP:0000563)	2.27551351
43	Increased corneal curvature (HP:0100692)	2.27551351
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24661041
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.21767240
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18873339
47	Absent/shortened dynein arms (HP:0200106)	2.18873339
48	Gait imbalance (HP:0002141)	2.18201778
49	Severe muscular hypotonia (HP:0006829)	2.17984958
50	Hemiparesis (HP:0001269)	2.17593095
51	Optic nerve hypoplasia (HP:0000609)	2.17312434
52	Congenital primary aphakia (HP:0007707)	2.16685315
53	Progressive inability to walk (HP:0002505)	2.16582394
54	Abnormality of B cell number (HP:0010975)	2.16563305
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.14089666
56	Sclerocornea (HP:0000647)	2.13579291
57	Large for gestational age (HP:0001520)	2.12850575
58	Furrowed tongue (HP:0000221)	2.11663269
59	Retinal dysplasia (HP:0007973)	2.09347500
60	Optic disc pallor (HP:0000543)	2.08334809
61	Decreased central vision (HP:0007663)	2.08253755
62	Asplenia (HP:0001746)	2.04679962
63	Nephrogenic diabetes insipidus (HP:0009806)	2.02880964
64	Congenital hepatic fibrosis (HP:0002612)	2.02015719
65	Ketosis (HP:0001946)	2.00673688
66	Ketoacidosis (HP:0001993)	1.98857643
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98772892
68	Thyroiditis (HP:0100646)	1.97957905
69	IgG deficiency (HP:0004315)	1.97212614
70	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95957425
71	Abnormal urine output (HP:0012590)	1.95188658
72	Tetany (HP:0001281)	1.94316273
73	Male pseudohermaphroditism (HP:0000037)	1.93007979
74	Postaxial foot polydactyly (HP:0001830)	1.92997856
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92353110
76	Pachygyria (HP:0001302)	1.90288976
77	Polyphagia (HP:0002591)	1.90202778
78	Short tibia (HP:0005736)	1.89861202
79	Hyperventilation (HP:0002883)	1.89270417
80	Abnormal biliary tract physiology (HP:0012439)	1.85407268
81	Bile duct proliferation (HP:0001408)	1.85407268
82	Increased serum lactate (HP:0002151)	1.84794110
83	Progressive microcephaly (HP:0000253)	1.83983846
84	Lactic acidosis (HP:0003128)	1.83231680
85	Prostate neoplasm (HP:0100787)	1.82009131
86	Anterior segment dysgenesis (HP:0007700)	1.80994897
87	Abnormality of the pons (HP:0007361)	1.79948805
88	Hypoplasia of the pons (HP:0012110)	1.79169351
89	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78662152
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.78662152
91	Abnormality of vitamin B metabolism (HP:0004340)	1.78283758
92	Hyperglycinemia (HP:0002154)	1.77200450
93	Postaxial hand polydactyly (HP:0001162)	1.76751254
94	Cerebral edema (HP:0002181)	1.76551775
95	Anencephaly (HP:0002323)	1.74825441
96	Neoplasm of the adrenal cortex (HP:0100641)	1.74547594
97	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73878429
98	Absent speech (HP:0001344)	1.73581562
99	Lipid accumulation in hepatocytes (HP:0006561)	1.72932827
100	Abnormality of magnesium homeostasis (HP:0004921)	1.72915341

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.53837899
2	MAP4K2	3.24107180
3	PINK1	3.18382207
4	ADRBK2	2.78238601
5	TAOK3	2.60709931
6	TRIM28	2.58236768
7	WNK3	2.47425768
8	ZAK	2.39130226
9	GRK1	2.25786377
10	WNK4	2.25722604
11	PASK	2.12585455
12	TLK1	2.03412935
13	MAP3K4	2.00610130
14	NUAK1	1.92296666
15	BMPR1B	1.90597503
16	TXK	1.79276519
17	MAP2K7	1.76464516
18	MAPK13	1.72716285
19	EPHA3	1.51724781
20	INSRR	1.48805075
21	CSNK1G3	1.47676859
22	STK39	1.43892617
23	CSNK1G1	1.38919464
24	ERBB3	1.33624148
25	BCR	1.30443722
26	DYRK2	1.30071281
27	PHKG1	1.30000526
28	PHKG2	1.30000526
29	OXSR1	1.29039758
30	CSNK1G2	1.24893002
31	CSNK1A1L	1.23859271
32	BCKDK	1.20871859
33	MUSK	1.16891818
34	DAPK2	1.16326834
35	ITK	1.15349977
36	PLK2	1.14286955
37	MST4	1.05786236
38	FGFR2	1.04068927
39	PAK3	1.02827349
40	TNIK	1.00483655
41	MAPKAPK3	0.98721391
42	EIF2AK3	0.97402203
43	PRKCE	0.96716887
44	TIE1	0.94139323
45	CAMKK2	0.93791663
46	IKBKB	0.92146143
47	CCNB1	0.91215063
48	VRK1	0.91203315
49	PLK4	0.87247972
50	VRK2	0.86210792
51	CASK	0.84809622
52	RPS6KA4	0.82023989
53	ADRBK1	0.76054466
54	TEC	0.71508004
55	PRKCQ	0.71329377
56	CAMKK1	0.70646972
57	PRKCG	0.69210327
58	DYRK3	0.67682340
59	MAP3K12	0.60662813
60	GRK6	0.60554964
61	RPS6KA5	0.59734016
62	MAPK15	0.58808862
63	ACVR1B	0.58785053
64	PLK3	0.56793442
65	MARK1	0.56327969
66	PRKCI	0.55609798
67	MAPKAPK5	0.54846916
68	PTK2B	0.52266156
69	MKNK2	0.52163806
70	IRAK1	0.51046545
71	FLT3	0.49717256
72	CSNK1A1	0.49052949
73	NLK	0.47252305
74	TAF1	0.46683740
75	PKN1	0.46318059
76	FER	0.44393536
77	ABL1	0.43688084
78	OBSCN	0.43398977
79	NEK2	0.41393681
80	CHUK	0.41161421
81	LIMK1	0.40482159
82	PRKACA	0.40150622
83	MAP2K4	0.40053458
84	MKNK1	0.40037658
85	MARK3	0.38781663
86	TGFBR1	0.38573052
87	STK16	0.37358995
88	KIT	0.37068252
89	CAMK2A	0.36496041
90	CSNK1D	0.35322272
91	TSSK6	0.34730065
92	SYK	0.34651911
93	SRPK1	0.33610747
94	PIK3CG	0.33411670
95	MAP4K1	0.33054973
96	PAK6	0.32993852
97	TNK2	0.32175082
98	MAP3K13	0.29425688
99	PRKCA	0.28089229
100	DAPK1	0.28026230

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.89385687
2	Phototransduction_Homo sapiens_hsa04744	2.75884197
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.63782825
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.40778350
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.15442284
6	Butanoate metabolism_Homo sapiens_hsa00650	2.14327186
7	Protein export_Homo sapiens_hsa03060	2.13768759
8	Parkinsons disease_Homo sapiens_hsa05012	2.11893804
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.04553980
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.00030954
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98215503
12	RNA polymerase_Homo sapiens_hsa03020	1.96948934
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96536241
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.96307232
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.96286146
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.95106932
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.92859440
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82508379
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80899728
20	RNA degradation_Homo sapiens_hsa03018	1.75859534
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.64690283
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.59729652
23	Nicotine addiction_Homo sapiens_hsa05033	1.58626152
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.53799706
25	Peroxisome_Homo sapiens_hsa04146	1.52193045
26	Regulation of autophagy_Homo sapiens_hsa04140	1.51708871
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.45172120
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.43194491
29	Caffeine metabolism_Homo sapiens_hsa00232	1.42884146
30	Basal transcription factors_Homo sapiens_hsa03022	1.41608114
31	Propanoate metabolism_Homo sapiens_hsa00640	1.41425441
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38992148
33	Homologous recombination_Homo sapiens_hsa03440	1.38925625
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.31694830
35	Sulfur metabolism_Homo sapiens_hsa00920	1.29652406
36	Huntingtons disease_Homo sapiens_hsa05016	1.26608405
37	Olfactory transduction_Homo sapiens_hsa04740	1.23689953
38	Alzheimers disease_Homo sapiens_hsa05010	1.22480477
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.16015721
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.15708815
41	Allograft rejection_Homo sapiens_hsa05330	1.15215349
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14865715
43	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12014213
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11368244
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03432706
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03086462
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02950978
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00805144
49	Graft-versus-host disease_Homo sapiens_hsa05332	1.00536908
50	Proteasome_Homo sapiens_hsa03050	0.99874724
51	Taste transduction_Homo sapiens_hsa04742	0.99686648
52	Asthma_Homo sapiens_hsa05310	0.98379429
53	Circadian rhythm_Homo sapiens_hsa04710	0.96550738
54	Retinol metabolism_Homo sapiens_hsa00830	0.94803617
55	Morphine addiction_Homo sapiens_hsa05032	0.92386718
56	Purine metabolism_Homo sapiens_hsa00230	0.92298341
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92263611
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91692243
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85754137
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83590168
61	GABAergic synapse_Homo sapiens_hsa04727	0.83386871
62	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82766589
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77982952
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77710350
65	ABC transporters_Homo sapiens_hsa02010	0.77058908
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.76233268
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76192421
68	Insulin secretion_Homo sapiens_hsa04911	0.75727221
69	Mineral absorption_Homo sapiens_hsa04978	0.72282976
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.71960305
71	Metabolic pathways_Homo sapiens_hsa01100	0.69794512
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68885168
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.67458228
74	Circadian entrainment_Homo sapiens_hsa04713	0.66802549
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65668843
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65667671
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62362877
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62212147
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60610139
80	One carbon pool by folate_Homo sapiens_hsa00670	0.59622808
81	Serotonergic synapse_Homo sapiens_hsa04726	0.57979317
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.57836211
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55853192
84	Sulfur relay system_Homo sapiens_hsa04122	0.55579450
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.51068732
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49290352
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46349690
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.45929384
89	Salivary secretion_Homo sapiens_hsa04970	0.45608086
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43800755
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41366006
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39542691
93	Fatty acid elongation_Homo sapiens_hsa00062	0.39057146
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.36210673
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33294124
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33208563
97	RNA transport_Homo sapiens_hsa03013	0.33054204
98	Fatty acid degradation_Homo sapiens_hsa00071	0.27627396
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.25581541
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24354257

FAM21EP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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