ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.09215289
2	coenzyme catabolic process (GO:0009109)	4.69741860
3	regulation of mitotic spindle checkpoint (GO:1903504)	4.67851226
4	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.67851226
5	regulation of autophagic vacuole assembly (GO:2000785)	4.46294885
6	DNA double-strand break processing (GO:0000729)	4.28283530
7	iron-sulfur cluster assembly (GO:0016226)	4.21036601
8	metallo-sulfur cluster assembly (GO:0031163)	4.21036601
9	opioid receptor signaling pathway (GO:0038003)	4.05206644
10	peptidyl-histidine modification (GO:0018202)	3.99840193
11	cellular response to zinc ion (GO:0071294)	3.97665863
12	nitric oxide mediated signal transduction (GO:0007263)	3.94035088
13	DNA deamination (GO:0045006)	3.88136747
14	ubiquinone metabolic process (GO:0006743)	3.86795882
15	regulation of vacuole organization (GO:0044088)	3.82028218
16	positive regulation of protein homooligomerization (GO:0032464)	3.52368192
17	positive regulation of catecholamine secretion (GO:0033605)	3.42781747
18	organelle membrane fusion (GO:0090174)	3.40973211
19	platelet dense granule organization (GO:0060155)	3.34110395
20	negative regulation of transcription by competitive promoter binding (GO:0010944)	3.24813925
21	autophagic vacuole fusion (GO:0000046)	3.22743510
22	cellular ketone body metabolic process (GO:0046950)	3.22472748
23	acrosome reaction (GO:0007340)	3.22120184
24	regulation of dopamine secretion (GO:0014059)	3.14808189
25	axoneme assembly (GO:0035082)	3.14777161
26	arginine catabolic process (GO:0006527)	3.14630277
27	protein-cofactor linkage (GO:0018065)	3.13816586
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.12590042
29	NADH dehydrogenase complex assembly (GO:0010257)	3.12590042
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.12590042
31	protein complex biogenesis (GO:0070271)	3.11555573
32	AMP metabolic process (GO:0046033)	3.06517122
33	positive regulation of mitochondrial fission (GO:0090141)	2.98194087
34	mitochondrion degradation (GO:0000422)	2.97960260
35	dicarboxylic acid catabolic process (GO:0043649)	2.96581021
36	cofactor catabolic process (GO:0051187)	2.92278750
37	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.89514759
38	water-soluble vitamin biosynthetic process (GO:0042364)	2.88440634
39	RNA destabilization (GO:0050779)	2.87943272
40	behavioral response to nicotine (GO:0035095)	2.85510192
41	pyrimidine dimer repair (GO:0006290)	2.84175172
42	L-alpha-amino acid transmembrane transport (GO:1902475)	2.83654105
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.83304601
44	ubiquinone biosynthetic process (GO:0006744)	2.83005216
45	sulfation (GO:0051923)	2.81430983
46	response to peptidoglycan (GO:0032494)	2.79932121
47	C-terminal protein lipidation (GO:0006501)	2.78618626
48	C-terminal protein amino acid modification (GO:0018410)	2.78085510
49	organic cation transport (GO:0015695)	2.76520004
50	ketone body metabolic process (GO:1902224)	2.76393832
51	epithelial cilium movement (GO:0003351)	2.75502387
52	sperm motility (GO:0030317)	2.75436520
53	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.75358285
54	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.75358285
55	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.75358285
56	potassium ion export (GO:0071435)	2.73079361
57	base-excision repair, AP site formation (GO:0006285)	2.72361140
58	protein localization to cilium (GO:0061512)	2.70296851
59	quinone metabolic process (GO:1901661)	2.68125093
60	positive regulation of amine transport (GO:0051954)	2.66732324
61	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.66228645
62	interleukin-6-mediated signaling pathway (GO:0070102)	2.63343699
63	negative regulation of acute inflammatory response (GO:0002674)	2.63091857
64	virion assembly (GO:0019068)	2.62054229
65	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.61069505
66	actin nucleation (GO:0045010)	2.60120763
67	positive regulation of T-helper 1 type immune response (GO:0002827)	2.59253566
68	multicellular organism reproduction (GO:0032504)	2.58933905
69	coenzyme A metabolic process (GO:0015936)	2.58823818
70	GPI anchor metabolic process (GO:0006505)	2.58488815
71	regulation of spindle checkpoint (GO:0090231)	2.56818384
72	GPI anchor biosynthetic process (GO:0006506)	2.56725676
73	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56082370
74	protein K11-linked deubiquitination (GO:0035871)	2.55282242
75	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.55053703
76	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.54495858
77	pyrimidine nucleobase catabolic process (GO:0006208)	2.53940434
78	purine-containing compound salvage (GO:0043101)	2.53602002
79	sleep (GO:0030431)	2.51877053
80	negative regulation of cell cycle arrest (GO:0071157)	2.51340710
81	intraciliary transport (GO:0042073)	2.48839067
82	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.48721052
83	developmental pigmentation (GO:0048066)	2.48490282
84	gamma-aminobutyric acid transport (GO:0015812)	2.47994424
85	basic amino acid transport (GO:0015802)	2.47050909
86	alanine transport (GO:0032328)	2.45932977
87	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.45436628
88	glycolipid biosynthetic process (GO:0009247)	2.45148661
89	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.43565540
90	succinate metabolic process (GO:0006105)	2.43117567
91	indolalkylamine catabolic process (GO:0046218)	2.42569510
92	tryptophan catabolic process (GO:0006569)	2.42569510
93	indole-containing compound catabolic process (GO:0042436)	2.42569510
94	preassembly of GPI anchor in ER membrane (GO:0016254)	2.42361418
95	ADP metabolic process (GO:0046031)	2.42344209
96	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.41448065
97	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.41448065
98	relaxation of smooth muscle (GO:0044557)	2.40738194
99	insulin secretion (GO:0030073)	2.40483178
100	response to gravity (GO:0009629)	2.39713008

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.90891430
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.54672585
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.39686517
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.87069151
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.41426449
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.14802654
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.52566670
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.36499957
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21351819
10	VDR_22108803_ChIP-Seq_LS180_Human	1.95046048
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.92701310
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.81715365
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79882685
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.79757781
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79049639
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.73365509
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.69190325
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.68242965
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63259909
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.62929385
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.61657484
22	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.57900836
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53650234
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.53650234
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45740473
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42410101
27	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.40095827
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38259576
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36244197
30	NANOG_20526341_ChIP-Seq_ESCs_Human	1.35843522
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35339412
32	GATA3_26560356_Chip-Seq_TH2_Human	1.33125024
33	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.31767688
34	RAC3_21632823_ChIP-Seq_H3396_Human	1.30530167
35	ERA_21632823_ChIP-Seq_H3396_Human	1.28929125
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28075370
37	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27234094
38	P300_19829295_ChIP-Seq_ESCs_Human	1.27005260
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26952603
40	FUS_26573619_Chip-Seq_HEK293_Human	1.25355251
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25266071
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.23433676
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.22347374
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22110956
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20141942
46	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.18974421
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17778024
48	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.17656812
49	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.16949870
50	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.15923447
51	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.12750982
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11621393
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10729977
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10235496
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09724819
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06429261
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06429261
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.05159519
59	GATA3_27048872_Chip-Seq_THYMUS_Human	1.03655829
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03304363
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03304363
62	NCOR_22424771_ChIP-Seq_293T_Human	1.03189944
63	MYC_19829295_ChIP-Seq_ESCs_Human	1.02519172
64	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.01594790
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01536890
66	STAT1_20625510_ChIP-Seq_HELA_Human	1.01254524
67	ERG_20517297_ChIP-Seq_VCAP_Human	1.00567407
68	TP53_22573176_ChIP-Seq_HFKS_Human	0.99500420
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99365519
70	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97258205
71	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.95835387
72	EWS_26573619_Chip-Seq_HEK293_Human	0.95569977
73	ELK1_19687146_ChIP-ChIP_HELA_Human	0.94047500
74	BCL6_27268052_Chip-Seq_Bcells_Human	0.93669446
75	CIITA_25753668_ChIP-Seq_RAJI_Human	0.91867842
76	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91644805
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91434016
78	TFEB_21752829_ChIP-Seq_HELA_Human	0.90776323
79	AR_25329375_ChIP-Seq_VCAP_Human	0.89304772
80	MYC_18940864_ChIP-ChIP_HL60_Human	0.88834890
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87958138
82	P300_27268052_Chip-Seq_Bcells_Human	0.87496186
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.84696422
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.82992652
85	MYB_26560356_Chip-Seq_TH2_Human	0.82675634
86	GABP_19822575_ChIP-Seq_HepG2_Human	0.81866076
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.81296898
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.80982966
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.79260312
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.79071417
91	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.78710326
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.78242374
93	FOXP3_21729870_ChIP-Seq_TREG_Human	0.78093470
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77085955
95	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.76891218
96	RXR_22108803_ChIP-Seq_LS180_Human	0.76648859
97	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.76511145
98	CBP_21632823_ChIP-Seq_H3396_Human	0.75559012
99	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.74153778
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.74144036

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.88102732
2	MP0000015_abnormal_ear_pigmentation	3.14931383
3	MP0003724_increased_susceptibility_to	2.91682483
4	MP0002837_dystrophic_cardiac_calcinosis	2.82416739
5	MP0006072_abnormal_retinal_apoptosis	2.81990067
6	MP0005410_abnormal_fertilization	2.61353718
7	MP0002138_abnormal_hepatobiliary_system	2.40724414
8	MP0002822_catalepsy	2.37282291
9	MP0001529_abnormal_vocalization	2.30671461
10	MP0002638_abnormal_pupillary_reflex	2.27702852
11	MP0001905_abnormal_dopamine_level	2.17869536
12	MP0005174_abnormal_tail_pigmentation	2.15022375
13	MP0002102_abnormal_ear_morphology	1.99735456
14	MP0000465_gastrointestinal_hemorrhage	1.98237040
15	MP0002009_preneoplasia	1.97246188
16	MP0001984_abnormal_olfaction	1.88090987
17	MP0002876_abnormal_thyroid_physiology	1.87842993
18	MP0003436_decreased_susceptibility_to	1.84804794
19	MP0003880_abnormal_central_pattern	1.83494546
20	MP0006036_abnormal_mitochondrial_physio	1.82847238
21	MP0001968_abnormal_touch/_nociception	1.74939400
22	MP0005058_abnormal_lysosome_morphology	1.69610278
23	MP0002653_abnormal_ependyma_morphology	1.69159983
24	MP0005645_abnormal_hypothalamus_physiol	1.56812805
25	MP0008260_abnormal_autophagy	1.55490559
26	MP0005084_abnormal_gallbladder_morpholo	1.54297137
27	MP0005253_abnormal_eye_physiology	1.54274567
28	MP0005646_abnormal_pituitary_gland	1.53755520
29	MP0006035_abnormal_mitochondrial_morpho	1.44427856
30	MP0002139_abnormal_hepatobiliary_system	1.43311071
31	MP0001835_abnormal_antigen_presentation	1.39476059
32	MP0001188_hyperpigmentation	1.37878512
33	MP0003656_abnormal_erythrocyte_physiolo	1.37323216
34	MP0004147_increased_porphyrin_level	1.31961518
35	MP0000516_abnormal_urinary_system	1.26098007
36	MP0005367_renal/urinary_system_phenotyp	1.26098007
37	MP0010386_abnormal_urinary_bladder	1.25334451
38	MP0000538_abnormal_urinary_bladder	1.24865079
39	MP0005075_abnormal_melanosome_morpholog	1.20558563
40	MP0003718_maternal_effect	1.20420850
41	MP0009785_altered_susceptibility_to	1.20056592
42	MP0000685_abnormal_immune_system	1.19214253
43	MP0001764_abnormal_homeostasis	1.19191339
44	MP0001986_abnormal_taste_sensitivity	1.16071029
45	MP0009046_muscle_twitch	1.14518358
46	MP0006276_abnormal_autonomic_nervous	1.12292958
47	MP0009764_decreased_sensitivity_to	1.11326001
48	MP0000343_altered_response_to	1.10247143
49	MP0008875_abnormal_xenobiotic_pharmacok	1.09623425
50	MP0005166_decreased_susceptibility_to	1.09566957
51	MP0001502_abnormal_circadian_rhythm	1.08380214
52	MP0002166_altered_tumor_susceptibility	1.08380163
53	MP0002132_abnormal_respiratory_system	1.08214544
54	MP0002693_abnormal_pancreas_physiology	1.05947407
55	MP0003303_peritoneal_inflammation	1.05282127
56	MP0005000_abnormal_immune_tolerance	1.05019220
57	MP0005423_abnormal_somatic_nervous	1.04883649
58	MP0002419_abnormal_innate_immunity	1.04097440
59	MP0002272_abnormal_nervous_system	1.03960289
60	MP0008004_abnormal_stomach_pH	1.00524889
61	MP0005394_taste/olfaction_phenotype	0.97800957
62	MP0005499_abnormal_olfactory_system	0.97800957
63	MP0008877_abnormal_DNA_methylation	0.95597829
64	MP0008872_abnormal_physiological_respon	0.94205902
65	MP0001929_abnormal_gametogenesis	0.93834068
66	MP0005464_abnormal_platelet_physiology	0.93406025
67	MP0004885_abnormal_endolymph	0.92935774
68	MP0005671_abnormal_response_to	0.92466914
69	MP0001501_abnormal_sleep_pattern	0.92061567
70	MP0001919_abnormal_reproductive_system	0.90315925
71	MP0002095_abnormal_skin_pigmentation	0.88748018
72	MP0002160_abnormal_reproductive_system	0.88307181
73	MP0002452_abnormal_antigen_presenting	0.88275893
74	MP0005551_abnormal_eye_electrophysiolog	0.88243615
75	MP0002723_abnormal_immune_serum	0.86466323
76	MP0001800_abnormal_humoral_immune	0.85724151
77	MP0001270_distended_abdomen	0.85694869
78	MP0008789_abnormal_olfactory_epithelium	0.84436700
79	MP0005389_reproductive_system_phenotype	0.82877939
80	MP0003698_abnormal_male_reproductive	0.82481075
81	MP0003878_abnormal_ear_physiology	0.81375030
82	MP0005377_hearing/vestibular/ear_phenot	0.81375030
83	MP0003172_abnormal_lysosome_physiology	0.79252342
84	MP0009697_abnormal_copulation	0.78682875
85	MP0002736_abnormal_nociception_after	0.78269167
86	MP0005379_endocrine/exocrine_gland_phen	0.77844487
87	MP0000372_irregular_coat_pigmentation	0.77702374
88	MP0004484_altered_response_of	0.77596057
89	MP0000569_abnormal_digit_pigmentation	0.76463226
90	MP0002148_abnormal_hypersensitivity_rea	0.75594946
91	MP0001664_abnormal_digestion	0.75365306
92	MP0002420_abnormal_adaptive_immunity	0.74246791
93	MP0001819_abnormal_immune_cell	0.73973203
94	MP0005025_abnormal_response_to	0.73197325
95	MP0005334_abnormal_fat_pad	0.72786009
96	MP0003195_calcinosis	0.71420915
97	MP0001533_abnormal_skeleton_physiology	0.70690870
98	MP0003122_maternal_imprinting	0.70645252
99	MP0002163_abnormal_gland_morphology	0.70535594
100	MP0009745_abnormal_behavioral_response	0.69579980

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.15657780
2	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.15657780
3	Stomach cancer (HP:0012126)	4.13034166
4	Hypothermia (HP:0002045)	3.37577067
5	Retinal dysplasia (HP:0007973)	3.10123759
6	Type II lissencephaly (HP:0007260)	3.08756466
7	Eosinophilia (HP:0001880)	3.06161618
8	Hepatocellular necrosis (HP:0001404)	3.05154730
9	Hypoglycemic seizures (HP:0002173)	2.96045716
10	Mitochondrial inheritance (HP:0001427)	2.89426523
11	Hepatic necrosis (HP:0002605)	2.88408485
12	Abnormality of liposaccharide metabolism (HP:0010968)	2.85691682
13	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.85691682
14	Abnormality of glycolipid metabolism (HP:0010969)	2.85691682
15	3-Methylglutaconic aciduria (HP:0003535)	2.82638356
16	Progressive macrocephaly (HP:0004481)	2.79798306
17	Ketosis (HP:0001946)	2.75608569
18	Stomatitis (HP:0010280)	2.70232853
19	Acute necrotizing encephalopathy (HP:0006965)	2.62274962
20	Pancreatic cysts (HP:0001737)	2.57723022
21	Clumsiness (HP:0002312)	2.53388512
22	Absent thumb (HP:0009777)	2.51358688
23	Granulocytopenia (HP:0001913)	2.50682291
24	Hypoglycemic coma (HP:0001325)	2.48285278
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.47296011
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.44713600
27	Medial flaring of the eyebrow (HP:0010747)	2.40458509
28	Abnormality of eosinophils (HP:0001879)	2.39666133
29	Chronic hepatic failure (HP:0100626)	2.39312550
30	Panhypogammaglobulinemia (HP:0003139)	2.37981642
31	Median cleft lip (HP:0000161)	2.37562146
32	Severe visual impairment (HP:0001141)	2.36752729
33	Symptomatic seizures (HP:0011145)	2.36244053
34	Cerebellar dysplasia (HP:0007033)	2.35786633
35	Type 2 muscle fiber atrophy (HP:0003554)	2.34011640
36	Prostate neoplasm (HP:0100787)	2.33609957
37	Increased IgM level (HP:0003496)	2.33594443
38	Abnormality of the columella (HP:0009929)	2.31277435
39	Absent speech (HP:0001344)	2.25370272
40	Abnormality of the prostate (HP:0008775)	2.22783071
41	Ketoacidosis (HP:0001993)	2.22607370
42	Abnormal protein glycosylation (HP:0012346)	2.21884285
43	Abnormal glycosylation (HP:0012345)	2.21884285
44	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.21884285
45	Abnormal protein N-linked glycosylation (HP:0012347)	2.21884285
46	Postural instability (HP:0002172)	2.21188469
47	Increased CSF lactate (HP:0002490)	2.20997050
48	Methylmalonic acidemia (HP:0002912)	2.20859100
49	Hyperinsulinemic hypoglycemia (HP:0000825)	2.20711911
50	Abnormal ciliary motility (HP:0012262)	2.20142244
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20090324
52	Abnormal respiratory motile cilium physiology (HP:0012261)	2.16969648
53	Abolished electroretinogram (ERG) (HP:0000550)	2.14412323
54	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.11430951
55	Attenuation of retinal blood vessels (HP:0007843)	2.10906788
56	Methylmalonic aciduria (HP:0012120)	2.10073439
57	Gait imbalance (HP:0002141)	2.09530180
58	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08563521
59	Congenital primary aphakia (HP:0007707)	2.04863861
60	Pancreatic fibrosis (HP:0100732)	2.03127969
61	Large for gestational age (HP:0001520)	2.01843096
62	Thyroiditis (HP:0100646)	2.01453208
63	True hermaphroditism (HP:0010459)	2.01181069
64	Metaphyseal dysplasia (HP:0100255)	2.01042272
65	Increased circulating renin level (HP:0000848)	1.99541396
66	Acute encephalopathy (HP:0006846)	1.99114768
67	Hemiparesis (HP:0001269)	1.98809408
68	Squamous cell carcinoma (HP:0002860)	1.98616611
69	IgG deficiency (HP:0004315)	1.98135201
70	Polyuria (HP:0000103)	1.97845675
71	Type I transferrin isoform profile (HP:0003642)	1.97732897
72	Lactic acidosis (HP:0003128)	1.94389736
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93943103
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.93943103
75	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.93735869
76	Inability to walk (HP:0002540)	1.91563475
77	Muscle fiber atrophy (HP:0100295)	1.89810384
78	Neutropenia (HP:0001875)	1.88686679
79	Microvesicular hepatic steatosis (HP:0001414)	1.87819834
80	Dry hair (HP:0011359)	1.87120874
81	Hypomagnesemia (HP:0002917)	1.87113640
82	Leukocytosis (HP:0001974)	1.86637766
83	Cerebral edema (HP:0002181)	1.86302996
84	Nephrogenic diabetes insipidus (HP:0009806)	1.86129958
85	Reduced antithrombin III activity (HP:0001976)	1.85381388
86	Opisthotonus (HP:0002179)	1.84941401
87	Abnormality of DNA repair (HP:0003254)	1.81156022
88	Lipid accumulation in hepatocytes (HP:0006561)	1.81144733
89	Hematochezia (HP:0002573)	1.80912170
90	Severe combined immunodeficiency (HP:0004430)	1.80346216
91	Rhinitis (HP:0012384)	1.79866011
92	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.79673461
93	Dicarboxylic aciduria (HP:0003215)	1.79673461
94	Resting tremor (HP:0002322)	1.77833063
95	Respiratory failure (HP:0002878)	1.75050949
96	Polydipsia (HP:0001959)	1.72022901
97	Abnormal drinking behavior (HP:0030082)	1.72022901
98	Pachygyria (HP:0001302)	1.71980044
99	Abnormality of midbrain morphology (HP:0002418)	1.71667652
100	Molar tooth sign on MRI (HP:0002419)	1.71667652

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.63017955
2	FRK	4.01995856
3	MAP2K7	2.88084285
4	TAOK3	2.60416381
5	MARK3	2.60170370
6	TLK1	2.46339975
7	DYRK3	2.40737439
8	ZAK	2.31746420
9	CSNK1G3	2.15408768
10	EPHA3	2.06362524
11	CSNK1A1L	1.97475606
12	CSNK1G2	1.95233347
13	MAP3K4	1.83648986
14	INSRR	1.77728693
15	MAP2K2	1.77228859
16	CASK	1.76577538
17	PRKD3	1.76329305
18	CSNK1G1	1.66272783
19	RPS6KA4	1.61765829
20	GRK6	1.56439452
21	GRK1	1.42099235
22	IKBKB	1.32527267
23	TEC	1.29262983
24	MAPK13	1.28404396
25	TRIM28	1.22942788
26	OBSCN	1.22519679
27	IRAK1	1.15964580
28	RPS6KA5	1.14158290
29	DYRK2	1.13701012
30	MST4	1.04517518
31	SYK	1.03958076
32	FGFR2	1.03004645
33	CDK3	1.02393327
34	TBK1	0.99823780
35	BCR	0.97138799
36	MAP4K2	0.96525855
37	PHKG1	0.96337843
38	PHKG2	0.96337843
39	PIM2	0.95252670
40	IKBKE	0.93095208
41	BTK	0.89920715
42	TESK2	0.89150261
43	NME2	0.89046074
44	ERBB3	0.88318351
45	PTK2B	0.85256303
46	ADRBK2	0.84144403
47	CCNB1	0.82542550
48	MAPKAPK3	0.80558192
49	WNK3	0.80457687
50	ITK	0.79443005
51	FGFR3	0.79189002
52	KIT	0.73510983
53	BLK	0.72142955
54	STK38	0.71984456
55	MAP4K1	0.71042256
56	RPS6KA2	0.66571710
57	PRKCE	0.66183213
58	MAP3K5	0.65577155
59	MAPK15	0.63076888
60	EPHB1	0.62400690
61	BCKDK	0.61809350
62	GRK7	0.61600051
63	ABL1	0.61335503
64	TESK1	0.61289727
65	ZAP70	0.61048585
66	ABL2	0.60501546
67	LYN	0.60011615
68	KDR	0.59201721
69	MAPKAPK2	0.57649911
70	PRKG2	0.54324473
71	WNK4	0.52961318
72	HIPK2	0.51106945
73	MYLK	0.50667715
74	FER	0.49643842
75	RPS6KA1	0.49085402
76	IRAK4	0.48867063
77	NEK2	0.48712169
78	BMPR1B	0.48444017
79	CAMK4	0.48152986
80	OXSR1	0.48083995
81	PKN1	0.46173595
82	PRKAA1	0.44907829
83	MAP3K1	0.42861254
84	PRKCQ	0.42094782
85	IRAK2	0.42020014
86	VRK1	0.41726285
87	CSNK1A1	0.38714673
88	RPS6KA6	0.38538759
89	RPS6KC1	0.38454263
90	RPS6KL1	0.38454263
91	HCK	0.35576631
92	CDK19	0.35107595
93	PLK2	0.32683210
94	CDK14	0.32527092
95	MAP3K11	0.30974659
96	PRKD2	0.28172722
97	CDC7	0.27832968
98	TAOK1	0.27588310
99	EGFR	0.26145324
100	FLT3	0.25992088

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.12873043
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.07409232
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.04358453
4	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.98587736
5	Butanoate metabolism_Homo sapiens_hsa00650	2.95695787
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.76638089
7	Allograft rejection_Homo sapiens_hsa05330	2.44293810
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.25247736
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22327360
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.17066247
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.10790652
12	Olfactory transduction_Homo sapiens_hsa04740	2.09978078
13	Parkinsons disease_Homo sapiens_hsa05012	2.06769461
14	Collecting duct acid secretion_Homo sapiens_hsa04966	1.92746868
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.90851131
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87928595
17	Regulation of autophagy_Homo sapiens_hsa04140	1.77141378
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.71022499
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.60731784
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.58651344
21	Protein export_Homo sapiens_hsa03060	1.58151730
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.57894822
23	Fatty acid elongation_Homo sapiens_hsa00062	1.55263173
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.51637614
25	Renin secretion_Homo sapiens_hsa04924	1.43803586
26	Circadian rhythm_Homo sapiens_hsa04710	1.39879724
27	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.34894686
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34366315
29	Phototransduction_Homo sapiens_hsa04744	1.33065833
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.31376711
31	Phagosome_Homo sapiens_hsa04145	1.30516501
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.25723827
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25394272
34	Homologous recombination_Homo sapiens_hsa03440	1.25312215
35	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.24243118
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14379073
37	Peroxisome_Homo sapiens_hsa04146	1.13021528
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09710064
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04903799
40	Circadian entrainment_Homo sapiens_hsa04713	1.01268026
41	Propanoate metabolism_Homo sapiens_hsa00640	1.01102750
42	GABAergic synapse_Homo sapiens_hsa04727	1.00814692
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00312957
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.96155034
45	Tuberculosis_Homo sapiens_hsa05152	0.91443936
46	Alzheimers disease_Homo sapiens_hsa05010	0.90859498
47	Legionellosis_Homo sapiens_hsa05134	0.88061964
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.87930902
49	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.83688004
50	Insulin secretion_Homo sapiens_hsa04911	0.80840418
51	Lysosome_Homo sapiens_hsa04142	0.79322170
52	Viral myocarditis_Homo sapiens_hsa05416	0.79173166
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77005206
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75677121
55	Antigen processing and presentation_Homo sapiens_hsa04612	0.73055867
56	Arginine biosynthesis_Homo sapiens_hsa00220	0.71374397
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70741690
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70684801
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70644652
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70602685
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70100577
62	Herpes simplex infection_Homo sapiens_hsa05168	0.69120652
63	Huntingtons disease_Homo sapiens_hsa05016	0.69076777
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.68184649
65	Leishmaniasis_Homo sapiens_hsa05140	0.64710149
66	RNA degradation_Homo sapiens_hsa03018	0.64607804
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64346836
68	Salivary secretion_Homo sapiens_hsa04970	0.63718863
69	Taste transduction_Homo sapiens_hsa04742	0.63617688
70	Purine metabolism_Homo sapiens_hsa00230	0.62313249
71	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57614812
72	Proteasome_Homo sapiens_hsa03050	0.57443785
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57043139
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.56957793
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.55869762
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54352881
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.53320301
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53174508
79	Metabolic pathways_Homo sapiens_hsa01100	0.53028885
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49588167
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.47818725
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47561685
83	Pertussis_Homo sapiens_hsa05133	0.47366642
84	Alcoholism_Homo sapiens_hsa05034	0.47287112
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45848292
86	Caffeine metabolism_Homo sapiens_hsa00232	0.45540837
87	Serotonergic synapse_Homo sapiens_hsa04726	0.43221358
88	Glutathione metabolism_Homo sapiens_hsa00480	0.42543462
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41451347
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41361184
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.41316578
92	Amphetamine addiction_Homo sapiens_hsa05031	0.40215818
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.40166979
94	Morphine addiction_Homo sapiens_hsa05032	0.39326218
95	Other glycan degradation_Homo sapiens_hsa00511	0.38499891
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37472068
97	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.36883219
98	Cocaine addiction_Homo sapiens_hsa05030	0.35000969
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34316087
100	African trypanosomiasis_Homo sapiens_hsa05143	0.34044379

FAM21FP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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