FAM220A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.46759542
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.22226186
3porphyrin-containing compound biosynthetic process (GO:0006779)6.21111243
4retinal cone cell development (GO:0046549)5.79322457
5heme biosynthetic process (GO:0006783)5.64617466
6tetrapyrrole biosynthetic process (GO:0033014)5.45535069
7piRNA metabolic process (GO:0034587)5.25019395
8glycine transport (GO:0015816)5.24689031
9centriole replication (GO:0007099)5.17820734
10regulation of cell maturation (GO:1903429)5.14501967
11oocyte development (GO:0048599)5.02538646
12synapsis (GO:0007129)4.95712574
13regulation of histone H3-K9 methylation (GO:0051570)4.87241774
14microtubule severing (GO:0051013)4.76210531
15regulation of acrosome reaction (GO:0060046)4.74169875
16monoubiquitinated protein deubiquitination (GO:0035520)4.68862139
17erythrocyte development (GO:0048821)4.64014906
18DNA damage response, signal transduction resulting in transcription (GO:0042772)4.62879759
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55683854
20protein K6-linked ubiquitination (GO:0085020)4.54274481
21DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.45973973
22gene silencing by RNA (GO:0031047)4.38262077
23porphyrin-containing compound metabolic process (GO:0006778)4.37528900
24regulation of steroid hormone secretion (GO:2000831)4.30437609
25negative regulation of histone methylation (GO:0031061)4.30409888
26spermatid nucleus differentiation (GO:0007289)4.26026947
27mitotic chromosome condensation (GO:0007076)4.23124403
28positive regulation of gastrulation (GO:2000543)4.08859343
29fusion of sperm to egg plasma membrane (GO:0007342)4.08088490
30microtubule depolymerization (GO:0007019)4.05203509
31male meiosis (GO:0007140)4.05192664
32chromosome organization involved in meiosis (GO:0070192)4.03816760
33regulation of meiosis (GO:0040020)4.02976552
34protein localization to kinetochore (GO:0034501)4.00098412
35mitotic metaphase plate congression (GO:0007080)3.95779538
36regulation of female gonad development (GO:2000194)3.94629453
37negative regulation of reproductive process (GO:2000242)3.92726262
38positive regulation of histone H3-K4 methylation (GO:0051571)3.90579808
39hemoglobin metabolic process (GO:0020027)3.89581366
40oogenesis (GO:0048477)3.85493569
41regulation of exit from mitosis (GO:0007096)3.80147400
42erythrocyte maturation (GO:0043249)3.80041539
43meiotic cell cycle (GO:0051321)3.78082607
44centriole assembly (GO:0098534)3.77935259
45heme metabolic process (GO:0042168)3.77049186
46fertilization (GO:0009566)3.72101007
47cardiac myofibril assembly (GO:0055003)3.69647071
48response to insecticide (GO:0017085)3.67960069
49negative regulation of smooth muscle cell differentiation (GO:0051151)3.66987318
50binding of sperm to zona pellucida (GO:0007339)3.65590566
51sperm motility (GO:0030317)3.64330669
52nucleus organization (GO:0006997)3.63327730
53sarcomere organization (GO:0045214)3.58908924
54snRNA transcription (GO:0009301)3.57125711
55oocyte maturation (GO:0001556)3.54550446
56protein localization to chromosome, centromeric region (GO:0071459)3.53672982
57DNA packaging (GO:0006323)3.53008843
58relaxation of smooth muscle (GO:0044557)3.51819376
59L-amino acid import (GO:0043092)3.49568425
60myofibril assembly (GO:0030239)3.47200636
61multicellular organism reproduction (GO:0032504)3.46239478
62meiotic cell cycle process (GO:1903046)3.44640406
63negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.43854120
64sperm capacitation (GO:0048240)3.38000726
65spermatogenesis (GO:0007283)3.37820372
66male gamete generation (GO:0048232)3.36538732
67synaptonemal complex organization (GO:0070193)3.36294465
68negative regulation of inclusion body assembly (GO:0090084)3.35335836
69female gamete generation (GO:0007292)3.34457047
70CENP-A containing nucleosome assembly (GO:0034080)3.33749743
71regulation of response to osmotic stress (GO:0047484)3.33002647
72regulation of meiosis I (GO:0060631)3.31849850
73sperm-egg recognition (GO:0035036)3.31109158
74acrosome reaction (GO:0007340)3.30864950
75labyrinthine layer development (GO:0060711)3.30130106
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28494821
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28494821
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.28494821
79gamete generation (GO:0007276)3.28289459
80regulation of meiotic cell cycle (GO:0051445)3.27438621
81plasma membrane fusion (GO:0045026)3.27422278
82metaphase plate congression (GO:0051310)3.27030781
83histone H2A ubiquitination (GO:0033522)3.26756348
84cerebral cortex neuron differentiation (GO:0021895)3.25677060
85response to methylmercury (GO:0051597)3.22797914
86protein localization to chromosome (GO:0034502)3.21680170
87DNA damage induced protein phosphorylation (GO:0006975)3.20898674
88protein polyglutamylation (GO:0018095)3.20821153
89synaptonemal complex assembly (GO:0007130)3.20386301
90spermatid development (GO:0007286)3.20098219
91single fertilization (GO:0007338)3.18188936
92motile cilium assembly (GO:0044458)3.17442429
93meiosis I (GO:0007127)3.16900623
94translesion synthesis (GO:0019985)3.15598202
95regulation of spindle organization (GO:0090224)3.14563661
96mitotic sister chromatid segregation (GO:0000070)3.14511061
97gene silencing (GO:0016458)3.13644762
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11080497
99attachment of spindle microtubules to kinetochore (GO:0008608)3.08917702
100paraxial mesoderm development (GO:0048339)3.08459767
101vesicle transport along microtubule (GO:0047496)3.08033834
102microtubule nucleation (GO:0007020)3.06885185
103germ cell development (GO:0007281)3.06502046
104meiotic chromosome segregation (GO:0045132)3.06384523
105histone H2A monoubiquitination (GO:0035518)3.06162537
106calcium ion-dependent exocytosis (GO:0017156)3.04521204
107primitive streak formation (GO:0090009)3.01670815
108nuclear pore organization (GO:0006999)3.00228591
109chromatin remodeling at centromere (GO:0031055)2.99703057
110DNA methylation involved in gamete generation (GO:0043046)2.99595284
111cytoplasmic microtubule organization (GO:0031122)2.98891282
112microtubule polymerization or depolymerization (GO:0031109)2.98023369
113regulation of double-strand break repair via homologous recombination (GO:0010569)2.97748343
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97480643
115nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.97314659
116cardiac muscle cell development (GO:0055013)2.96998131
117negative regulation of meiosis (GO:0045835)2.96966128
118regulation of sister chromatid cohesion (GO:0007063)2.95720062
119ventricular cardiac muscle cell development (GO:0055015)2.93184412
120regulation of DNA methylation (GO:0044030)2.92711747
121phosphorelay signal transduction system (GO:0000160)2.92295249
122positive regulation of meiosis (GO:0045836)2.91614608
123negative regulation of potassium ion transmembrane transport (GO:1901380)2.91298460
124positive regulation of chromosome segregation (GO:0051984)2.91236681
125establishment of chromosome localization (GO:0051303)2.89792122
126regulation of clathrin-mediated endocytosis (GO:2000369)2.86583848
127histone H3-K9 demethylation (GO:0033169)2.84842484
128DNA alkylation (GO:0006305)2.82224191
129DNA methylation (GO:0006306)2.82224191
130nucleosome organization (GO:0034728)2.81073581
131protein autoubiquitination (GO:0051865)2.80932034
132neuron fate determination (GO:0048664)2.80383531
133protein kinase C signaling (GO:0070528)2.80163368
134amino acid import (GO:0043090)2.79779153
135cytoplasmic mRNA processing body assembly (GO:0033962)2.78988872
136positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.78840141
137protein targeting to Golgi (GO:0000042)2.77190757
138somite rostral/caudal axis specification (GO:0032525)2.76480436
139chromatin assembly or disassembly (GO:0006333)2.76285069
140negative regulation of cell aging (GO:0090344)2.74862873
141cardiac cell development (GO:0055006)2.74726680
142muscle filament sliding (GO:0030049)2.74604145
143actin-myosin filament sliding (GO:0033275)2.74604145
144sarcoplasmic reticulum calcium ion transport (GO:0070296)2.73822445
145positive regulation of reproductive process (GO:2000243)2.73593740
146peptidyl-threonine dephosphorylation (GO:0035970)2.73082930
147negative regulation of meiotic cell cycle (GO:0051447)2.72009790
148nucleosome assembly (GO:0006334)2.70460749
149positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69853567
150protein complex localization (GO:0031503)2.69473302
151male meiosis I (GO:0007141)2.66860984
152chromosome condensation (GO:0030261)2.66707238
153histone exchange (GO:0043486)2.64996004
154mitotic sister chromatid cohesion (GO:0007064)2.63365220
155regulation of histone H3-K27 methylation (GO:0061085)2.63312516
156reproduction (GO:0000003)2.63157198
157regulation of hippo signaling (GO:0035330)2.63091929
158respiratory system process (GO:0003016)2.62295706
159chromosome segregation (GO:0007059)2.62122937
160positive regulation of mitochondrial fission (GO:0090141)2.60750046
161protein monoubiquitination (GO:0006513)2.60583030
162positive regulation of microtubule polymerization (GO:0031116)2.59731079
163erythrocyte differentiation (GO:0030218)2.59265551
164meiotic nuclear division (GO:0007126)2.59169309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.01519510
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.48836680
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.20980620
4KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.12256902
5EZH2_22144423_ChIP-Seq_EOC_Human2.87394145
6ZNF263_19887448_ChIP-Seq_K562_Human2.73555967
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72684579
8GATA1_19941826_ChIP-Seq_K562_Human2.72629506
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.61854970
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53268546
11TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.48385599
12GBX2_23144817_ChIP-Seq_PC3_Human2.45066138
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40492756
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.36266550
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.36266550
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.36266550
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.29923076
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26950626
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11791316
20E2F7_22180533_ChIP-Seq_HELA_Human2.11426148
21GATA1_19941827_ChIP-Seq_MEL_Mouse1.95764458
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.95453444
23CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.90107428
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85235937
25RUNX1_26923725_Chip-Seq_HPCs_Mouse1.83704854
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80851622
27CBP_20019798_ChIP-Seq_JUKART_Human1.70863480
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70863480
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69713477
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66431194
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65992680
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62980165
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59439607
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59199555
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57292762
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.48527102
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38712836
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36198690
39GATA2_19941826_ChIP-Seq_K562_Human1.35466126
40SMAD4_21799915_ChIP-Seq_A2780_Human1.32612259
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.32384437
42REST_21632747_ChIP-Seq_MESCs_Mouse1.31466991
43AR_25329375_ChIP-Seq_VCAP_Human1.30871300
44KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28413154
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28327887
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27816005
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26417281
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25742167
49KDM2B_26808549_Chip-Seq_K562_Human1.25021010
50GATA1_19941827_ChIP-Seq_MEL86_Mouse1.24195929
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24154970
52FUS_26573619_Chip-Seq_HEK293_Human1.23581377
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22196049
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22111842
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22111842
56IRF1_19129219_ChIP-ChIP_H3396_Human1.21148869
57P300_19829295_ChIP-Seq_ESCs_Human1.20462832
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19641772
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.18859448
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17585614
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17394402
62TCF4_23295773_ChIP-Seq_U87_Human1.16079849
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15472535
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.12989753
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.12500236
66HTT_18923047_ChIP-ChIP_STHdh_Human1.12099046
67STAT3_23295773_ChIP-Seq_U87_Human1.11879937
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11856421
69OCT1_27270436_Chip-Seq_PROSTATE_Human1.10781267
70RNF2_27304074_Chip-Seq_NSC_Mouse1.10237925
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.10114377
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09281204
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.09251590
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08332069
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07020076
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05690733
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05657557
78NFYA_21822215_ChIP-Seq_K562_Human1.05565587
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05288185
80AR_21909140_ChIP-Seq_LNCAP_Human1.04246240
81IGF1R_20145208_ChIP-Seq_DFB_Human1.04016453
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03679463
83ETV1_20927104_ChIP-Seq_GIST48_Human1.03435630
84DROSHA_22980978_ChIP-Seq_HELA_Human1.03321972
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03282995
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02859165
87RUNX2_22187159_ChIP-Seq_PCA_Human1.02819425
88TAF15_26573619_Chip-Seq_HEK293_Human1.02076094
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01804776
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.01385338
91ERG_20517297_ChIP-Seq_VCAP_Human1.01116557
92ER_23166858_ChIP-Seq_MCF-7_Human1.00822299
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98583184
94TBL1_22424771_ChIP-Seq_293T_Human0.98301572
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98206822
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97901695
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97726511
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.97600430
99E2F1_21310950_ChIP-Seq_MCF-7_Human0.97420080
100ZNF274_21170338_ChIP-Seq_K562_Hela0.97261328
101CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96664864
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96164801
103GF1B_26923725_Chip-Seq_HPCs_Mouse0.95851433
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95709631
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95616814
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94225865
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93819108
108TP63_19390658_ChIP-ChIP_HaCaT_Human0.93512588
109OCT4_19829295_ChIP-Seq_ESCs_Human0.93499280
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93093923
111GF1_26923725_Chip-Seq_HPCs_Mouse0.93064609
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.92867225
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92762236
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91640316
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91571552
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90491543
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90439300
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90359809
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90138207
120PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89822592
121GATA3_21867929_ChIP-Seq_TH1_Mouse0.88748042
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.87361261
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.87361261
124FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87237969
125SMRT_27268052_Chip-Seq_Bcells_Human0.86972516
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86936672
127EWS_26573619_Chip-Seq_HEK293_Human0.86629218
128SCL_19346495_ChIP-Seq_HPC-7_Human0.86596256
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86239142
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84792200
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.84761663
132CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84578026
133CTCF_27219007_Chip-Seq_Bcells_Human0.84231143
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84167721
135VDR_22108803_ChIP-Seq_LS180_Human0.84019133
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83782523
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.83606145
138SALL4_22934838_ChIP-ChIP_CD34+_Human0.83120473
139NFYB_21822215_ChIP-Seq_K562_Human0.82758901
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.82755746
141TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82132372
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.82101976
143FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81330193
144CBP_21632823_ChIP-Seq_H3396_Human0.81263102
145FOXH1_21741376_ChIP-Seq_EPCs_Human0.81123269
146HNFA_21074721_ChIP-Seq_CACO-2_Human0.81025342
147GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80582083
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.80254171
149MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.80234046
150TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.79744984
151CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79586472
152NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79540438
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79377384
154WDR5_24793694_ChIP-Seq_LNCAP_Human0.79373351
155NANOG_20526341_ChIP-Seq_ESCs_Human0.79216484
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.78692861
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.77988935
158TP53_22573176_ChIP-Seq_HFKS_Human0.77974361
159FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77426688
160ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77412351
161GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77383620
162KDM2B_26808549_Chip-Seq_DND41_Human0.76353671
163JUN_21703547_ChIP-Seq_K562_Human0.75093090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.03546170
2MP0003656_abnormal_erythrocyte_physiolo5.06181059
3MP0005394_taste/olfaction_phenotype3.43300603
4MP0005499_abnormal_olfactory_system3.43300603
5MP0004147_increased_porphyrin_level3.21944654
6MP0002653_abnormal_ependyma_morphology3.06437610
7MP0008877_abnormal_DNA_methylation3.05923942
8MP0002837_dystrophic_cardiac_calcinosis2.86039954
9MP0000751_myopathy2.76559589
10MP0003879_abnormal_hair_cell2.67825422
11MP0002102_abnormal_ear_morphology2.64863180
12MP0004145_abnormal_muscle_electrophysio2.49297614
13MP0005410_abnormal_fertilization2.48943106
14MP0003890_abnormal_embryonic-extraembry2.48156801
15MP0010234_abnormal_vibrissa_follicle2.42296294
16MP0003111_abnormal_nucleus_morphology2.26240505
17MP0000749_muscle_degeneration2.22831466
18MP0004215_abnormal_myocardial_fiber2.17315990
19MP0005451_abnormal_body_composition2.15675485
20MP0001984_abnormal_olfaction2.15598549
21MP0003718_maternal_effect2.10317681
22MP0001929_abnormal_gametogenesis2.01046943
23MP0003077_abnormal_cell_cycle1.93638210
24MP0004036_abnormal_muscle_relaxation1.92931910
25MP0004185_abnormal_adipocyte_glucose1.90573660
26MP0002106_abnormal_muscle_physiology1.90535994
27MP0010094_abnormal_chromosome_stability1.90404322
28MP0010030_abnormal_orbit_morphology1.85352080
29MP0001529_abnormal_vocalization1.74490165
30MP0004484_altered_response_of1.69622442
31MP0004084_abnormal_cardiac_muscle1.69040650
32MP0000566_synostosis1.68730297
33MP0003787_abnormal_imprinting1.65156920
34MP0004859_abnormal_synaptic_plasticity1.63602730
35MP0004087_abnormal_muscle_fiber1.61787684
36MP0002272_abnormal_nervous_system1.61553639
37MP0005620_abnormal_muscle_contractility1.58670987
38MP0003693_abnormal_embryo_hatching1.56211880
39MP0003221_abnormal_cardiomyocyte_apopto1.52642627
40MP0002210_abnormal_sex_determination1.51157664
41MP0002139_abnormal_hepatobiliary_system1.49582176
42MP0003698_abnormal_male_reproductive1.46277424
43MP0004233_abnormal_muscle_weight1.46060553
44MP0000759_abnormal_skeletal_muscle1.44951560
45MP0005369_muscle_phenotype1.43230189
46MP0004510_myositis1.42470121
47MP0005360_urolithiasis1.37376664
48MP0000750_abnormal_muscle_regeneration1.34221203
49MP0004957_abnormal_blastocyst_morpholog1.32706617
50MP0000653_abnormal_sex_gland1.32257809
51MP0002972_abnormal_cardiac_muscle1.31630230
52MP0002138_abnormal_hepatobiliary_system1.27868616
53MP0003635_abnormal_synaptic_transmissio1.27222289
54MP0002161_abnormal_fertility/fecundity1.25729529
55MP0002332_abnormal_exercise_endurance1.24446971
56MP0006292_abnormal_olfactory_placode1.23496963
57MP0002877_abnormal_melanocyte_morpholog1.23102366
58MP0002269_muscular_atrophy1.22709160
59MP0003699_abnormal_female_reproductive1.22250798
60MP0003122_maternal_imprinting1.21844824
61MP0005187_abnormal_penis_morphology1.19263020
62MP0000631_abnormal_neuroendocrine_gland1.19020770
63MP0005330_cardiomyopathy1.19012108
64MP0008775_abnormal_heart_ventricle1.17939954
65MP0004142_abnormal_muscle_tone1.14407601
66MP0000762_abnormal_tongue_morphology1.12530867
67MP0001486_abnormal_startle_reflex1.12380149
68MP0004085_abnormal_heartbeat1.11589014
69MP0002160_abnormal_reproductive_system1.11386886
70MP0001502_abnormal_circadian_rhythm1.11202487
71MP0008995_early_reproductive_senescence1.10762068
72MP0003880_abnormal_central_pattern1.10378013
73MP0001119_abnormal_female_reproductive1.09854108
74MP0005423_abnormal_somatic_nervous1.07702392
75MP0003315_abnormal_perineum_morphology1.06125164
76MP0008057_abnormal_DNA_replication1.03428564
77MP0003183_abnormal_peptide_metabolism1.03220298
78MP0001145_abnormal_male_reproductive1.03093414
79MP0008260_abnormal_autophagy1.03018572
80MP0000350_abnormal_cell_proliferation1.00582953
81MP0005385_cardiovascular_system_phenoty1.00322744
82MP0001544_abnormal_cardiovascular_syste1.00322744
83MP0003137_abnormal_impulse_conducting0.96152762
84MP0009745_abnormal_behavioral_response0.95289785
85MP0004130_abnormal_muscle_cell0.95160957
86MP0001293_anophthalmia0.94356703
87MP0002063_abnormal_learning/memory/cond0.93770646
88MP0005551_abnormal_eye_electrophysiolog0.92999274
89MP0005646_abnormal_pituitary_gland0.92445944
90MP0002233_abnormal_nose_morphology0.91273209
91MP0006276_abnormal_autonomic_nervous0.91012981
92MP0002736_abnormal_nociception_after0.90837399
93MP0010630_abnormal_cardiac_muscle0.90486797
94MP0002067_abnormal_sensory_capabilities0.89567407
95MP0004811_abnormal_neuron_physiology0.88839364
96MP0002735_abnormal_chemical_nociception0.88638664
97MP0000778_abnormal_nervous_system0.88545628
98MP0008058_abnormal_DNA_repair0.87799385
99MP0006036_abnormal_mitochondrial_physio0.87094711
100MP0003937_abnormal_limbs/digits/tail_de0.86829642
101MP0001963_abnormal_hearing_physiology0.86766827
102MP0004270_analgesia0.86724963
103MP0002572_abnormal_emotion/affect_behav0.85502380
104MP0002163_abnormal_gland_morphology0.84782045
105MP0002009_preneoplasia0.84708443
106MP0000049_abnormal_middle_ear0.83991064
107MP0003828_pulmonary_edema0.82667656
108MP0001697_abnormal_embryo_size0.81964588
109MP0000733_abnormal_muscle_development0.81550226
110MP0001730_embryonic_growth_arrest0.81169306
111MP0000747_muscle_weakness0.80254288
112MP0006138_congestive_heart_failure0.80217667
113MP0002085_abnormal_embryonic_tissue0.78139294
114MP0010307_abnormal_tumor_latency0.78069909
115MP0003119_abnormal_digestive_system0.78042413
116MP0005647_abnormal_sex_gland0.77702465
117MP0002734_abnormal_mechanical_nocicepti0.77282921
118MP0002249_abnormal_larynx_morphology0.75106300
119MP0002127_abnormal_cardiovascular_syste0.74540646
120MP0003121_genomic_imprinting0.74131437
121MP0001849_ear_inflammation0.73032298
122MP0010368_abnormal_lymphatic_system0.73004576
123MP0001672_abnormal_embryogenesis/_devel0.72117729
124MP0005380_embryogenesis_phenotype0.72117729
125MP0005666_abnormal_adipose_tissue0.71765665
126MP0002638_abnormal_pupillary_reflex0.71475748
127MP0001986_abnormal_taste_sensitivity0.71454058
128MP0009250_abnormal_appendicular_skeleto0.71302388
129MP0000266_abnormal_heart_morphology0.71010597
130MP0000579_abnormal_nail_morphology0.70931719
131MP0002084_abnormal_developmental_patter0.70879416
132MP0003950_abnormal_plasma_membrane0.70760055
133MP0000026_abnormal_inner_ear0.68984272
134MP0009046_muscle_twitch0.68759853
135MP0008789_abnormal_olfactory_epithelium0.68690153
136MP0001905_abnormal_dopamine_level0.68196001
137MP0003123_paternal_imprinting0.67319386
138MP0002882_abnormal_neuron_morphology0.66324191
139MP0002234_abnormal_pharynx_morphology0.66161880
140MP0008932_abnormal_embryonic_tissue0.65828831
141MP0002557_abnormal_social/conspecific_i0.65564652
142MP0002064_seizures0.65293909
143MP0005395_other_phenotype0.65100189
144MP0001545_abnormal_hematopoietic_system0.63791208
145MP0005397_hematopoietic_system_phenotyp0.63791208
146MP0005645_abnormal_hypothalamus_physiol0.61763638
147MP0003861_abnormal_nervous_system0.61546571
148MP0002229_neurodegeneration0.58882629
149MP0002152_abnormal_brain_morphology0.58262226
150MP0005389_reproductive_system_phenotype0.57952871
151MP0005386_behavior/neurological_phenoty0.56590080
152MP0004924_abnormal_behavior0.56590080
153MP0000427_abnormal_hair_cycle0.56047846
154MP0002066_abnormal_motor_capabilities/c0.55159550

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)6.33957180
2Abnormality of the heme biosynthetic pathway (HP:0010472)5.97804266
3Hypochromic microcytic anemia (HP:0004840)5.74871912
4Supernumerary spleens (HP:0009799)5.25786176
5Male infertility (HP:0003251)5.13121135
6Cholelithiasis (HP:0001081)4.41068178
7Abnormal gallbladder physiology (HP:0012438)4.19208811
8Cholecystitis (HP:0001082)4.19208811
9Myokymia (HP:0002411)4.12306763
10Osteomalacia (HP:0002749)4.11831531
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.11430257
12Abnormality of abdominal situs (HP:0011620)4.08680786
13Abdominal situs inversus (HP:0003363)4.08680786
14Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.06580890
15Muscle fiber splitting (HP:0003555)4.01291295
16Exercise-induced myalgia (HP:0003738)3.99943785
17Acanthocytosis (HP:0001927)3.94560976
18Oligodactyly (hands) (HP:0001180)3.94327494
19Sudden death (HP:0001699)3.86387591
20Muscle hypertrophy of the lower extremities (HP:0008968)3.85068615
21Abnormal gallbladder morphology (HP:0012437)3.83128665
22Calf muscle hypertrophy (HP:0008981)3.78203347
23Anterior segment dysgenesis (HP:0007700)3.59925835
24Impulsivity (HP:0100710)3.57692905
25Muscle fiber inclusion bodies (HP:0100299)3.46510302
26Septo-optic dysplasia (HP:0100842)3.39272264
27Exercise-induced muscle cramps (HP:0003710)3.35772437
28Hypophosphatemic rickets (HP:0004912)3.35343388
29Muscle stiffness (HP:0003552)3.33687434
30Short tibia (HP:0005736)3.30464261
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.29623165
32Subaortic stenosis (HP:0001682)3.27807831
33Abnormality of the left ventricular outflow tract (HP:0011103)3.27807831
34Absent septum pellucidum (HP:0001331)3.20499120
35Bundle branch block (HP:0011710)3.18614154
36Birth length less than 3rd percentile (HP:0003561)3.16845942
37Lip pit (HP:0100267)3.16653686
38Median cleft lip (HP:0000161)3.10756137
39Papillary thyroid carcinoma (HP:0002895)3.10248077
40Reticulocytosis (HP:0001923)3.04402935
41Infertility (HP:0000789)2.99454837
42Truncal obesity (HP:0001956)2.97469445
43Gonadotropin excess (HP:0000837)2.91927089
44Abnormality of the calf musculature (HP:0001430)2.90853116
45Nemaline bodies (HP:0003798)2.88012069
46Diaphragmatic weakness (HP:0009113)2.87849276
47Focal motor seizures (HP:0011153)2.86793530
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.82612238
49Hypoplasia of the fovea (HP:0007750)2.82612238
50Atrial fibrillation (HP:0005110)2.82140716
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.81899870
52Myotonia (HP:0002486)2.80134167
53Paralysis (HP:0003470)2.79929843
54Primary atrial arrhythmia (HP:0001692)2.79110854
55Oligodactyly (HP:0012165)2.76964715
56Abnormality of the septum pellucidum (HP:0007375)2.75082674
57Ventricular tachycardia (HP:0004756)2.71387075
58Apathy (HP:0000741)2.69136390
59Abnormality of the fovea (HP:0000493)2.68904867
60Diminished motivation (HP:0000745)2.66302574
61Atonic seizures (HP:0010819)2.64125022
62Supraventricular tachycardia (HP:0004755)2.63661745
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.57714884
64Supraventricular arrhythmia (HP:0005115)2.53257899
65Breast hypoplasia (HP:0003187)2.53184849
66Hypochromic anemia (HP:0001931)2.49731995
67Abnormal ciliary motility (HP:0012262)2.49619773
68Abnormality of the gallbladder (HP:0005264)2.47028198
69Cone-rod dystrophy (HP:0000548)2.43496046
70Difficulty climbing stairs (HP:0003551)2.42978305
71Optic nerve hypoplasia (HP:0000609)2.38639979
72Difficulty running (HP:0009046)2.36790093
73Fetal akinesia sequence (HP:0001989)2.35241078
74Lipoatrophy (HP:0100578)2.32944360
75Childhood onset (HP:0011463)2.32111387
76Chromsome breakage (HP:0040012)2.29601796
77Areflexia of lower limbs (HP:0002522)2.29256842
78Tubulointerstitial nephritis (HP:0001970)2.28226651
79Abnormality of the phalanges of the hallux (HP:0010057)2.27523426
80Generalized aminoaciduria (HP:0002909)2.25493720
81Hyporeflexia of lower limbs (HP:0002600)2.25026696
82EMG: myopathic abnormalities (HP:0003458)2.23711600
83Abnormality of alanine metabolism (HP:0010916)2.23427910
84Hyperalaninemia (HP:0003348)2.23427910
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23427910
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23413556
87Type 1 muscle fiber predominance (HP:0003803)2.21899313
88Polycythemia (HP:0001901)2.21603114
89Patellar aplasia (HP:0006443)2.20480334
90Dysdiadochokinesis (HP:0002075)2.19900614
91Chronic hepatic failure (HP:0100626)2.19066318
92Premature ovarian failure (HP:0008209)2.16466685
93Maternal diabetes (HP:0009800)2.16276394
94Azoospermia (HP:0000027)2.15342356
95Chronic bronchitis (HP:0004469)2.14936358
96Febrile seizures (HP:0002373)2.14822191
97Skin pits (HP:0100276)2.13927134
98Hypokinesia (HP:0002375)2.13638305
99Facial hemangioma (HP:0000329)2.12863806
100Ankle contracture (HP:0006466)2.09415137
101Abnormal respiratory motile cilium physiology (HP:0012261)2.08619533
102Enlarged penis (HP:0000040)2.08356554
103Ventricular fibrillation (HP:0001663)2.05359894
104Breast aplasia (HP:0100783)2.05349572
105Abnormal spermatogenesis (HP:0008669)2.04020932
106Heterotopia (HP:0002282)2.03081794
107Heart block (HP:0012722)2.01797051
108Malnutrition (HP:0004395)2.01183411
109Asymmetric septal hypertrophy (HP:0001670)1.98909288
110Aplasia/Hypoplasia of the patella (HP:0006498)1.98007785
111Myoglobinuria (HP:0002913)1.97816525
112Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97714166
113Aplasia/Hypoplasia of the breasts (HP:0010311)1.97656134
114Microcytic anemia (HP:0001935)1.95988441
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95379256
116Sensory axonal neuropathy (HP:0003390)1.94736609
117Abnormal atrioventricular conduction (HP:0005150)1.94463704
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.93681190
119Hypoplastic iliac wings (HP:0002866)1.93618018
120Hydroureter (HP:0000072)1.92960451
121Absent/shortened dynein arms (HP:0200106)1.92583374
122Dynein arm defect of respiratory motile cilia (HP:0012255)1.92583374
123Proximal tubulopathy (HP:0000114)1.91951544
124Fair hair (HP:0002286)1.91030956
125Horizontal nystagmus (HP:0000666)1.89181436
126Dysmetric saccades (HP:0000641)1.88877744
127Syncope (HP:0001279)1.87232624
128Urethral obstruction (HP:0000796)1.85710108
129Capillary hemangiomas (HP:0005306)1.84921418
130Abnormality of lateral ventricle (HP:0030047)1.84640908
131Calcaneovalgus deformity (HP:0001848)1.83615023
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.82556090
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81279524
134Obstructive sleep apnea (HP:0002870)1.79746076
135Abnormal lung lobation (HP:0002101)1.78672761
136Subcapsular cataract (HP:0000523)1.78613258
137Congenital malformation of the right heart (HP:0011723)1.78155046
138Double outlet right ventricle (HP:0001719)1.78155046
139Nonprogressive disorder (HP:0003680)1.75238382
140Abnormality of the labia minora (HP:0012880)1.74780575
141Left ventricular hypertrophy (HP:0001712)1.74208526
142EMG: neuropathic changes (HP:0003445)1.74051202
143Progressive cerebellar ataxia (HP:0002073)1.73849884
144Abnormality of chromosome segregation (HP:0002916)1.73536788
145Insomnia (HP:0100785)1.72977360
146Rhinitis (HP:0012384)1.72095996
147Atrioventricular block (HP:0001678)1.71983554
148Wrist flexion contracture (HP:0001239)1.70995449
149Cortical dysplasia (HP:0002539)1.70893580
150Hip contracture (HP:0003273)1.70169571
151Anosmia (HP:0000458)1.70088531
152Conjunctival telangiectasia (HP:0000524)1.70007112
153Stillbirth (HP:0003826)1.69797695
154Impaired vibration sensation in the lower limbs (HP:0002166)1.69654844
155Ventricular arrhythmia (HP:0004308)1.69384342
156Pelvic girdle muscle weakness (HP:0003749)1.68675797
157Ulnar deviation of the wrist (HP:0003049)1.68039233
158Rhabdomyolysis (HP:0003201)1.67857193
159Neck muscle weakness (HP:0000467)1.67744562
160Mutism (HP:0002300)1.67660235
161Microglossia (HP:0000171)1.67522481
162Myopathic facies (HP:0002058)1.67493570
163Gowers sign (HP:0003391)1.67419143
164Shoulder girdle muscle weakness (HP:0003547)1.67280015
165Thyroid carcinoma (HP:0002890)1.66703673
166Insulin-resistant diabetes mellitus (HP:0000831)1.66553093
167Fatigable weakness (HP:0003473)1.66369173
168Progressive sensorineural hearing impairment (HP:0000408)1.65536901
169Abnormality of the anterior chamber (HP:0000593)1.63868613
170Bicornuate uterus (HP:0000813)1.63315560
171Hypoplasia of the brainstem (HP:0002365)1.61122414
172Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61122414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.00903042
2MAP3K63.95454553
3LATS13.66863981
4PRKD33.12364357
5KSR22.89997996
6NEK62.80202836
7MOS2.60276489
8DYRK22.56548975
9STK38L2.42939666
10EIF2AK12.22309037
11TAOK12.19306030
12MAP3K92.08688213
13BMPR22.03827795
14DMPK1.97208690
15MET1.91068621
16MUSK1.91050789
17PHKG11.87969281
18PHKG21.87969281
19CDK81.87432266
20CDC71.79063939
21OBSCN1.78670894
22TRIM281.70743190
23DYRK31.70391722
24MAPK131.57200282
25PINK11.56672544
26ERBB41.51409392
27EEF2K1.48463706
28MAPKAPK31.47687319
29ABL21.44561869
30RAF11.43809599
31PAK61.43477731
32STK31.43374712
33MAP3K41.41928329
34PDK31.41863169
35PDK41.41863169
36CDK91.36773648
37TTN1.36583763
38CHEK21.30642475
39PRKAA11.30218303
40MAP2K71.27897310
41MELK1.24328130
42EIF2AK31.23854121
43STK381.22287862
44NEK21.19465136
45STK241.18764459
46KSR11.18501895
47CSNK1G31.15046956
48TNIK1.12217135
49TRIB31.11594728
50PRKCI1.09489969
51GRK51.07876941
52PLK41.06494530
53STK41.06196153
54MAP2K41.05984433
55BRD41.05132790
56NEK91.03900183
57CSNK1G21.02112769
58CDK71.01338069
59NTRK31.00654490
60BRSK10.98987299
61TESK10.97953676
62PLK20.97121865
63CSNK1A1L0.94504724
64TLK10.93900793
65TTK0.92747345
66RET0.92732859
67PDK20.91446000
68MAPKAPK50.89433102
69PTK2B0.88933829
70TYRO30.88857466
71MARK10.87329925
72SGK20.83895780
73MAP3K50.82839345
74CDK190.81743941
75ARAF0.80607968
76BRAF0.79277263
77TAOK30.74101900
78SGK4940.74008735
79SGK2230.74008735
80PRKG10.71142873
81BUB10.67610776
82NLK0.67094888
83AURKA0.63803464
84HIPK20.63266615
85AURKB0.62842991
86TRPM70.61540331
87DYRK1A0.61530436
88CDK20.61379162
89PLK10.60496739
90MAPK110.59616497
91CDK50.57082994
92MAP4K20.56781632
93NME10.56360975
94SGK30.56100221
95PRKD20.55823766
96TIE10.55626799
97PNCK0.53013297
98ZAK0.52144863
99MAP3K130.52041195
100CSNK1D0.50615624
101WNK10.50046802
102MAP3K120.49573644
103CDK40.49192649
104PIK3CG0.48619285
105MAP2K10.48322646
106CDK10.47928579
107PLK30.47200379
108MAP3K80.46656163
109CDK120.46421265
110PDK10.45925824
111CASK0.45544028
112INSRR0.45411128
113CDK140.45107239
114PRKAA20.42821926
115MARK30.42486460
116CAMK2A0.42447464
117PKN20.40969419
118LMTK20.40689741
119GRK70.39928089
120PIM10.39484926
121EPHA40.39387764
122CDK11A0.39264886
123BMPR1B0.38786275
124STK390.38598862
125CAMK1G0.37912138
126PRKCZ0.37311337
127STK100.37180249
128CDK150.36641631
129CDK180.35717004
130BCR0.35083993
131ICK0.34470488
132AKT20.34110971
133DYRK1B0.33665881
134CSNK1G10.33400218
135VRK10.33377211
136MAP3K10.33259713
137PAK10.32886158
138CHEK10.32520613
139PTK20.32346455
140ILK0.31849782
141PDPK10.29428607
142RPS6KA50.29415146
143MAPK120.29133221
144ATM0.28827098
145ACVR1B0.28809623
146SGK10.28806723
147NTRK20.28806211
148PKN10.28360682
149CCNB10.28201031

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.19414465
2Cell cycle_Homo sapiens_hsa041102.73369087
3Mismatch repair_Homo sapiens_hsa034302.62580410
4Olfactory transduction_Homo sapiens_hsa047402.60092274
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.25902401
6Oocyte meiosis_Homo sapiens_hsa041142.14916413
7Systemic lupus erythematosus_Homo sapiens_hsa053222.09012752
8Synaptic vesicle cycle_Homo sapiens_hsa047212.03775945
9Circadian rhythm_Homo sapiens_hsa047101.99805252
10Basal transcription factors_Homo sapiens_hsa030221.96303331
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.94520148
12GABAergic synapse_Homo sapiens_hsa047271.80151928
13Dorso-ventral axis formation_Homo sapiens_hsa043201.78458844
14Cardiac muscle contraction_Homo sapiens_hsa042601.67248888
15Caffeine metabolism_Homo sapiens_hsa002321.63630630
16Morphine addiction_Homo sapiens_hsa050321.58660786
17RNA degradation_Homo sapiens_hsa030181.57723523
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57358288
19Ovarian steroidogenesis_Homo sapiens_hsa049131.56271990
20Pancreatic cancer_Homo sapiens_hsa052121.54246626
21Phototransduction_Homo sapiens_hsa047441.53959992
22Alcoholism_Homo sapiens_hsa050341.52496947
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46307003
24GnRH signaling pathway_Homo sapiens_hsa049121.45299131
25Dilated cardiomyopathy_Homo sapiens_hsa054141.37757829
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.29293419
27VEGF signaling pathway_Homo sapiens_hsa043701.28728774
28Renal cell carcinoma_Homo sapiens_hsa052111.27077400
29RNA polymerase_Homo sapiens_hsa030201.24830058
30Folate biosynthesis_Homo sapiens_hsa007901.23819570
31Long-term potentiation_Homo sapiens_hsa047201.21991735
32Choline metabolism in cancer_Homo sapiens_hsa052311.21798892
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21793612
34Fanconi anemia pathway_Homo sapiens_hsa034601.20861380
35mTOR signaling pathway_Homo sapiens_hsa041501.20543252
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20220954
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18422285
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18105800
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16913704
40Prolactin signaling pathway_Homo sapiens_hsa049171.16314888
41TGF-beta signaling pathway_Homo sapiens_hsa043501.15852233
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14946258
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13478921
44mRNA surveillance pathway_Homo sapiens_hsa030151.11974939
45Glioma_Homo sapiens_hsa052141.11317396
46Linoleic acid metabolism_Homo sapiens_hsa005911.10550325
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10092081
48FoxO signaling pathway_Homo sapiens_hsa040681.09970222
49Endometrial cancer_Homo sapiens_hsa052131.09875946
50p53 signaling pathway_Homo sapiens_hsa041151.09764925
51Ether lipid metabolism_Homo sapiens_hsa005651.09155463
52Taste transduction_Homo sapiens_hsa047421.07364141
53Non-small cell lung cancer_Homo sapiens_hsa052231.06791879
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05617870
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04561291
56MAPK signaling pathway_Homo sapiens_hsa040101.04273682
57Oxytocin signaling pathway_Homo sapiens_hsa049211.02783534
58Chronic myeloid leukemia_Homo sapiens_hsa052201.01157696
59Huntingtons disease_Homo sapiens_hsa050161.00879766
60Bladder cancer_Homo sapiens_hsa052191.00780172
61Long-term depression_Homo sapiens_hsa047301.00081551
62MicroRNAs in cancer_Homo sapiens_hsa052060.98982987
63Colorectal cancer_Homo sapiens_hsa052100.98489234
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95520032
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95260256
66RNA transport_Homo sapiens_hsa030130.93378376
67AMPK signaling pathway_Homo sapiens_hsa041520.92360879
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91461597
69Insulin signaling pathway_Homo sapiens_hsa049100.88507009
70Adherens junction_Homo sapiens_hsa045200.86723002
71Inositol phosphate metabolism_Homo sapiens_hsa005620.86005948
72Arginine and proline metabolism_Homo sapiens_hsa003300.84553294
73Glucagon signaling pathway_Homo sapiens_hsa049220.83226254
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82562794
75Melanoma_Homo sapiens_hsa052180.82329734
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82231739
77Prostate cancer_Homo sapiens_hsa052150.81738173
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.78354979
79Thyroid cancer_Homo sapiens_hsa052160.77929818
80Hippo signaling pathway_Homo sapiens_hsa043900.76130517
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76040088
82Viral carcinogenesis_Homo sapiens_hsa052030.75351906
83Viral myocarditis_Homo sapiens_hsa054160.74901325
84Fatty acid elongation_Homo sapiens_hsa000620.74822916
85Dopaminergic synapse_Homo sapiens_hsa047280.73530805
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72949274
87Estrogen signaling pathway_Homo sapiens_hsa049150.72747047
88Gap junction_Homo sapiens_hsa045400.71338678
89Cholinergic synapse_Homo sapiens_hsa047250.71265851
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70988152
91cAMP signaling pathway_Homo sapiens_hsa040240.70198553
92Glutamatergic synapse_Homo sapiens_hsa047240.69385165
93Base excision repair_Homo sapiens_hsa034100.68512263
94Ras signaling pathway_Homo sapiens_hsa040140.67754772
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67084381
96ErbB signaling pathway_Homo sapiens_hsa040120.65500373
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65086459
98DNA replication_Homo sapiens_hsa030300.64566633
99Tight junction_Homo sapiens_hsa045300.64111564
100Gastric acid secretion_Homo sapiens_hsa049710.63720933
101Calcium signaling pathway_Homo sapiens_hsa040200.62349975
102Wnt signaling pathway_Homo sapiens_hsa043100.62340424
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62094117
104Amphetamine addiction_Homo sapiens_hsa050310.59465167
105Small cell lung cancer_Homo sapiens_hsa052220.58677305
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.58486686
107Fatty acid biosynthesis_Homo sapiens_hsa000610.57747336
108Serotonergic synapse_Homo sapiens_hsa047260.57483812
109HIF-1 signaling pathway_Homo sapiens_hsa040660.56842922
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55282782
111Nucleotide excision repair_Homo sapiens_hsa034200.54306886
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54241700
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54201575
114Malaria_Homo sapiens_hsa051440.53190444
115Parkinsons disease_Homo sapiens_hsa050120.52167852
116Bile secretion_Homo sapiens_hsa049760.52016818
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51755198
118Type II diabetes mellitus_Homo sapiens_hsa049300.51594598
119Circadian entrainment_Homo sapiens_hsa047130.51010711
120Purine metabolism_Homo sapiens_hsa002300.50784438
121Arginine biosynthesis_Homo sapiens_hsa002200.50520232
122Insulin resistance_Homo sapiens_hsa049310.50391259
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.50237546
124Nicotine addiction_Homo sapiens_hsa050330.49667940
125Hepatitis B_Homo sapiens_hsa051610.48107424
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47672611
127Homologous recombination_Homo sapiens_hsa034400.47654175
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47644249
129Shigellosis_Homo sapiens_hsa051310.47492540
130Regulation of autophagy_Homo sapiens_hsa041400.47469446
131Notch signaling pathway_Homo sapiens_hsa043300.46912774
132ABC transporters_Homo sapiens_hsa020100.46670194
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44496065
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43396147
135Insulin secretion_Homo sapiens_hsa049110.43280487
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41887473
137Cocaine addiction_Homo sapiens_hsa050300.40700800
138Pyruvate metabolism_Homo sapiens_hsa006200.38357498
139Melanogenesis_Homo sapiens_hsa049160.36958234
140Propanoate metabolism_Homo sapiens_hsa006400.35389491
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34142544
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33097579
143Biosynthesis of amino acids_Homo sapiens_hsa012300.31631988
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.30893922

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