ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of posttranscriptional gene silencing (GO:0060147)	8.27342728
2	regulation of gene silencing by miRNA (GO:0060964)	8.27342728
3	regulation of gene silencing by RNA (GO:0060966)	8.27342728
4	establishment of integrated proviral latency (GO:0075713)	6.08037308
5	pre-miRNA processing (GO:0031054)	5.35760284
6	nuclear pore complex assembly (GO:0051292)	5.34809465
7	histone arginine methylation (GO:0034969)	5.19877496
8	regulation of histone H3-K9 methylation (GO:0051570)	5.16542653
9	protein complex localization (GO:0031503)	5.00361962
10	paraxial mesoderm development (GO:0048339)	4.95203135
11	establishment of viral latency (GO:0019043)	4.85493420
12	nuclear pore organization (GO:0006999)	4.79782223
13	L-alpha-amino acid transmembrane transport (GO:1902475)	4.73685698
14	L-serine metabolic process (GO:0006563)	4.56785814
15	negative regulation of histone methylation (GO:0031061)	4.53520684
16	heterochromatin organization (GO:0070828)	4.42217751
17	glycerophospholipid catabolic process (GO:0046475)	4.18411722
18	positive regulation of SMAD protein import into nucleus (GO:0060391)	4.11403013
19	pore complex assembly (GO:0046931)	4.03552555
20	peptidyl-arginine omega-N-methylation (GO:0035247)	3.97003418
21	regulation of cell fate specification (GO:0042659)	3.90691693
22	protein localization to kinetochore (GO:0034501)	3.88275962
23	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.87664845
24	regulation of translation, ncRNA-mediated (GO:0045974)	3.87664845
25	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.87664845
26	negative regulation of inclusion body assembly (GO:0090084)	3.83467775
27	regulation of gene silencing (GO:0060968)	3.81548033
28	protein refolding (GO:0042026)	3.79342239
29	lysine metabolic process (GO:0006553)	3.68851114
30	lysine catabolic process (GO:0006554)	3.68851114
31	glomerular visceral epithelial cell development (GO:0072015)	3.67768645
32	negative regulation of gene silencing (GO:0060969)	3.65591847
33	single strand break repair (GO:0000012)	3.64079690
34	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.63626322
35	DNA unwinding involved in DNA replication (GO:0006268)	3.59470040
36	regulation of helicase activity (GO:0051095)	3.58891468
37	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.49499260
38	glomerular epithelial cell development (GO:0072310)	3.46171537
39	lung-associated mesenchyme development (GO:0060484)	3.34717667
40	aspartate family amino acid catabolic process (GO:0009068)	3.34578552
41	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.33893118
42	establishment of apical/basal cell polarity (GO:0035089)	3.30920385
43	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	3.30727810
44	IMP biosynthetic process (GO:0006188)	3.30176043
45	cellular protein complex localization (GO:0034629)	3.29744316
46	peptidyl-arginine methylation (GO:0018216)	3.26595569
47	peptidyl-arginine N-methylation (GO:0035246)	3.26595569
48	protein localization to chromosome, centromeric region (GO:0071459)	3.25150577
49	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.21581293
50	IMP metabolic process (GO:0046040)	3.20498412
51	double-strand break repair via nonhomologous end joining (GO:0006303)	3.17513070
52	non-recombinational repair (GO:0000726)	3.17513070
53	DNA strand elongation involved in DNA replication (GO:0006271)	3.15515529
54	negative regulation of JUN kinase activity (GO:0043508)	3.14883867
55	protein-DNA complex disassembly (GO:0032986)	3.12611855
56	nucleosome disassembly (GO:0006337)	3.12611855
57	notochord development (GO:0030903)	3.09237041
58	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.08798850
59	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.07694566
60	regulation of mitotic spindle checkpoint (GO:1903504)	3.07694566
61	regulation of stem cell maintenance (GO:2000036)	3.07576770
62	telomere maintenance via telomerase (GO:0007004)	3.05970282
63	regulation of centriole replication (GO:0046599)	3.05010679
64	DNA strand elongation (GO:0022616)	3.04381711
65	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.03953306
66	establishment of monopolar cell polarity (GO:0061162)	3.03953306
67	regulation of chromatin silencing (GO:0031935)	3.03069934
68	positive regulation of catenin import into nucleus (GO:0035413)	3.00524189
69	ribosome biogenesis (GO:0042254)	2.97347632
70	DNA ligation (GO:0006266)	2.93777268
71	DNA replication-dependent nucleosome organization (GO:0034723)	2.92292319
72	DNA replication-dependent nucleosome assembly (GO:0006335)	2.92292319
73	negative regulation of mRNA processing (GO:0050686)	2.86725185
74	ncRNA catabolic process (GO:0034661)	2.82545458
75	cranial nerve development (GO:0021545)	2.82070858
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.79863047
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.79863047
78	convergent extension (GO:0060026)	2.78949161
79	polarized epithelial cell differentiation (GO:0030859)	2.78904607
80	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.78242954
81	regulation of mitochondrial translation (GO:0070129)	2.72256075
82	glycine metabolic process (GO:0006544)	2.71069056
83	DNA geometric change (GO:0032392)	2.69575120
84	regulation of inclusion body assembly (GO:0090083)	2.69008612
85	regulation of cell fate commitment (GO:0010453)	2.67630550
86	regulation of telomere maintenance via telomerase (GO:0032210)	2.67372627
87	protein-cofactor linkage (GO:0018065)	2.62148417
88	DNA damage response, detection of DNA damage (GO:0042769)	2.61973652
89	ATP-dependent chromatin remodeling (GO:0043044)	2.61920919
90	DNA duplex unwinding (GO:0032508)	2.61807104
91	histone H3-K36 demethylation (GO:0070544)	2.61724572
92	DNA replication checkpoint (GO:0000076)	2.61050492
93	negative regulation of DNA recombination (GO:0045910)	2.60547571
94	serine family amino acid catabolic process (GO:0009071)	2.59468011
95	regulation of SMAD protein import into nucleus (GO:0060390)	2.59392755
96	RNA-dependent DNA replication (GO:0006278)	2.58249658
97	chromatin assembly (GO:0031497)	2.57614062
98	negative regulation of mRNA metabolic process (GO:1903312)	2.57519913
99	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.56535381
100	DNA replication initiation (GO:0006270)	2.55246340

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.35002892
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.82202239
3	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.57021882
4	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.57021882
5	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.57021882
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.89580131
7	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.81350589
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.76588002
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.72544104
10	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.65342686
11	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	2.44403441
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.43992022
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.35154083
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.34607785
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.32803476
16	SOX2_16153702_ChIP-ChIP_HESCs_Human	2.28068020
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.18459921
18	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.15435686
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.15432029
20	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.15341091
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12553777
22	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.11725128
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.09140687
24	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	2.08125724
25	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.03535319
26	NANOG_18555785_ChIP-Seq_MESCs_Mouse	2.01239813
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.99952888
28	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.97332570
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.90507535
30	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.87521593
31	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.85051362
32	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.80212004
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.78169786
34	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75989200
35	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.75496855
36	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.71508271
37	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.69923842
38	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.69676971
39	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.69360339
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.64901876
41	XRN2_22483619_ChIP-Seq_HELA_Human	1.63188025
42	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.61566238
43	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.61411926
44	DCP1A_22483619_ChIP-Seq_HELA_Human	1.58668373
45	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.57890742
46	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.57602316
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.52301371
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50925294
49	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.50013726
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.49734167
51	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.49591848
52	TTF2_22483619_ChIP-Seq_HELA_Human	1.49040382
53	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.48548985
54	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.46314339
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44715545
56	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.44260618
57	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.42628991
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41361482
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.41124478
60	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.38809222
61	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.34129831
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34006084
63	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.33536537
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32847231
65	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.32562906
66	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.32366447
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31379942
68	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.30034722
69	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.24533266
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.24484173
71	KAP1_27257070_Chip-Seq_ESCs_Mouse	1.21776149
72	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21511095
73	POU5F1_18692474_ChIP-Seq_MESCs_Mouse	1.19516492
74	SOX2_18692474_ChIP-Seq_MESCs_Mouse	1.16502281
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15146283
76	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	1.11667451
77	ZNF263_19887448_ChIP-Seq_K562_Human	1.11194478
78	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.07780917
79	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.07657115
80	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.07641331
81	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.07455078
82	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.06270611
83	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	1.04456617
84	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.04230445
85	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.01683034
86	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.99227438
87	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.98994162
88	VDR_22108803_ChIP-Seq_LS180_Human	0.96781476
89	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96199949
90	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.95715338
91	MYC_18940864_ChIP-ChIP_HL60_Human	0.93387310
92	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.92265431
93	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.92010694
94	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.91586748
95	VDR_23849224_ChIP-Seq_CD4+_Human	0.91392524
96	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.90782155
97	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.90437478
98	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.88512701
99	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.88371925
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.88081775

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	6.27472273
2	MP0003890_abnormal_embryonic-extraembry	4.02436541
3	MP0003693_abnormal_embryo_hatching	3.85569821
4	MP0008877_abnormal_DNA_methylation	3.35585687
5	MP0009672_abnormal_birth_weight	3.29724151
6	MP0003941_abnormal_skin_development	3.02963365
7	MP0004957_abnormal_blastocyst_morpholog	2.96501213
8	MP0003878_abnormal_ear_physiology	2.85971629
9	MP0005377_hearing/vestibular/ear_phenot	2.85971629
10	MP0003111_abnormal_nucleus_morphology	2.80561184
11	MP0008057_abnormal_DNA_replication	2.43601313
12	MP0008058_abnormal_DNA_repair	2.36201737
13	MP0003718_maternal_effect	2.35279895
14	MP0003122_maternal_imprinting	2.33999264
15	MP0010094_abnormal_chromosome_stability	2.29115681
16	MP0008932_abnormal_embryonic_tissue	2.21578943
17	MP0001730_embryonic_growth_arrest	2.20819353
18	MP0004233_abnormal_muscle_weight	2.05994470
19	MP0003077_abnormal_cell_cycle	1.98624060
20	MP0004264_abnormal_extraembryonic_tissu	1.87640004
21	MP0002084_abnormal_developmental_patter	1.79617908
22	MP0003787_abnormal_imprinting	1.78244098
23	MP0003121_genomic_imprinting	1.78050986
24	MP0009703_decreased_birth_body	1.67599612
25	MP0003937_abnormal_limbs/digits/tail_de	1.66943709
26	MP0003119_abnormal_digestive_system	1.63981038
27	MP0004133_heterotaxia	1.62899223
28	MP0002085_abnormal_embryonic_tissue	1.62507254
29	MP0004197_abnormal_fetal_growth/weight/	1.62049108
30	MP0005380_embryogenesis_phenotype	1.53316898
31	MP0001672_abnormal_embryogenesis/_devel	1.53316898
32	MP0003567_abnormal_fetal_cardiomyocyte	1.49983597
33	MP0006072_abnormal_retinal_apoptosis	1.48674816
34	MP0010352_gastrointestinal_tract_polyps	1.47469695
35	MP0002736_abnormal_nociception_after	1.41380760
36	MP0010307_abnormal_tumor_latency	1.38784761
37	MP0001849_ear_inflammation	1.34615077
38	MP0010030_abnormal_orbit_morphology	1.33992981
39	MP0005410_abnormal_fertilization	1.33910038
40	MP0001697_abnormal_embryo_size	1.31791775
41	MP0001293_anophthalmia	1.29439826
42	MP0002697_abnormal_eye_size	1.28780702
43	MP0003984_embryonic_growth_retardation	1.28213401
44	MP0002080_prenatal_lethality	1.27234868
45	MP0002088_abnormal_embryonic_growth/wei	1.26738906
46	MP0001485_abnormal_pinna_reflex	1.25091590
47	MP0004272_abnormal_basement_membrane	1.21824038
48	MP0000537_abnormal_urethra_morphology	1.17783714
49	MP0000350_abnormal_cell_proliferation	1.15680208
50	MP0003943_abnormal_hepatobiliary_system	1.15615918
51	MP0003861_abnormal_nervous_system	1.13458376
52	MP0000566_synostosis	1.11638832
53	MP0001286_abnormal_eye_development	1.09069131
54	MP0008007_abnormal_cellular_replicative	1.06555552
55	MP0000490_abnormal_crypts_of	1.05199674
56	MP0001188_hyperpigmentation	1.04889784
57	MP0002111_abnormal_tail_morphology	1.02398539
58	MP0001929_abnormal_gametogenesis	1.01648776
59	MP0000579_abnormal_nail_morphology	1.00387509
60	MP0005551_abnormal_eye_electrophysiolog	0.99983841
61	MP0001299_abnormal_eye_distance/	0.99820654
62	MP0005395_other_phenotype	0.99221723
63	MP0002089_abnormal_postnatal_growth/wei	0.90405560
64	MP0002086_abnormal_extraembryonic_tissu	0.90239214
65	MP0003221_abnormal_cardiomyocyte_apopto	0.89231334
66	MP0005257_abnormal_intraocular_pressure	0.88534876
67	MP0001145_abnormal_male_reproductive	0.87493299
68	MP0003566_abnormal_cell_adhesion	0.87271469
69	MP0002210_abnormal_sex_determination	0.87052573
70	MP0000428_abnormal_craniofacial_morphol	0.86755054
71	MP0003698_abnormal_male_reproductive	0.86370272
72	MP0002102_abnormal_ear_morphology	0.85627835
73	MP0003283_abnormal_digestive_organ	0.83596967
74	MP0009046_muscle_twitch	0.81139597
75	MP0000049_abnormal_middle_ear	0.80420530
76	MP0005623_abnormal_meninges_morphology	0.80008285
77	MP0000358_abnormal_cell_content/	0.78836445
78	MP0006035_abnormal_mitochondrial_morpho	0.77270784
79	MP0001661_extended_life_span	0.74921537
80	MP0002090_abnormal_vision	0.74627309
81	MP0000313_abnormal_cell_death	0.73331022
82	MP0000432_abnormal_head_morphology	0.72353272
83	MP0008260_abnormal_autophagy	0.71916446
84	MP0002161_abnormal_fertility/fecundity	0.70627661
85	MP0003123_paternal_imprinting	0.69025028
86	MP0004270_analgesia	0.68750661
87	MP0002653_abnormal_ependyma_morphology	0.68541491
88	MP0000653_abnormal_sex_gland	0.68188085
89	MP0002233_abnormal_nose_morphology	0.66759364
90	MP0000955_abnormal_spinal_cord	0.65524435
91	MP0002152_abnormal_brain_morphology	0.65343950
92	MP0008770_decreased_survivor_rate	0.64749400
93	MP0002796_impaired_skin_barrier	0.64372966
94	MP0000631_abnormal_neuroendocrine_gland	0.64009375
95	MP0010630_abnormal_cardiac_muscle	0.63796142
96	MP0003136_yellow_coat_color	0.62238374
97	MP0003786_premature_aging	0.60185473
98	MP0004811_abnormal_neuron_physiology	0.59759257
99	MP0003011_delayed_dark_adaptation	0.59357171
100	MP0001177_atelectasis	0.58318344

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	5.93999314
2	Abnormal hair whorl (HP:0010721)	5.06450368
3	Hepatoblastoma (HP:0002884)	4.52485826
4	Chronic bronchitis (HP:0004469)	3.87502569
5	Selective tooth agenesis (HP:0001592)	3.69088731
6	Spastic diplegia (HP:0001264)	3.38772452
7	Choanal stenosis (HP:0000452)	3.36708594
8	Pendular nystagmus (HP:0012043)	3.14057058
9	Failure to thrive in infancy (HP:0001531)	3.12224721
10	Nephroblastoma (Wilms tumor) (HP:0002667)	2.89846938
11	Colon cancer (HP:0003003)	2.86402936
12	Septo-optic dysplasia (HP:0100842)	2.85620361
13	Cortical dysplasia (HP:0002539)	2.82057372
14	Generalized hypotonia (HP:0001290)	2.80260184
15	Pseudobulbar signs (HP:0002200)	2.70495205
16	Abnormal number of incisors (HP:0011064)	2.65034918
17	Embryonal renal neoplasm (HP:0011794)	2.64604389
18	Hypogonadotrophic hypogonadism (HP:0000044)	2.63248720
19	Facial cleft (HP:0002006)	2.61454937
20	Synostosis involving the elbow (HP:0003938)	2.59995353
21	Humeroradial synostosis (HP:0003041)	2.59995353
22	Nasal speech (HP:0001611)	2.57284779
23	Cerebral hypomyelination (HP:0006808)	2.52319599
24	Carpal bone hypoplasia (HP:0001498)	2.51110906
25	Bilateral microphthalmos (HP:0007633)	2.48979525
26	Persistence of primary teeth (HP:0006335)	2.44924261
27	Bronchomalacia (HP:0002780)	2.44499118
28	Shoulder girdle muscle weakness (HP:0003547)	2.40146433
29	Ependymoma (HP:0002888)	2.39036219
30	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31785129
31	Chronic hepatic failure (HP:0100626)	2.29996152
32	Broad thumb (HP:0011304)	2.29048965
33	Chromsome breakage (HP:0040012)	2.28810141
34	Optic nerve hypoplasia (HP:0000609)	2.28640337
35	Hyperglycinuria (HP:0003108)	2.27527345
36	Diastasis recti (HP:0001540)	2.26870457
37	Birth length less than 3rd percentile (HP:0003561)	2.26677706
38	Partial agenesis of the corpus callosum (HP:0001338)	2.24352738
39	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.22467410
40	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.20741983
41	Impulsivity (HP:0100710)	2.17366154
42	Abnormal lung lobation (HP:0002101)	2.15518138
43	Maternal diabetes (HP:0009800)	2.11129994
44	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.10038277
45	Duplication of thumb phalanx (HP:0009942)	2.02516740
46	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.01355516
47	Scrotal hypoplasia (HP:0000046)	2.01219490
48	Medulloblastoma (HP:0002885)	2.00926984
49	Abnormality of the middle phalanges of the toes (HP:0010183)	1.97935321
50	Pancreatic islet-cell hyperplasia (HP:0004510)	1.97314726
51	Pelvic girdle muscle weakness (HP:0003749)	1.94002996
52	Absent forearm bone (HP:0003953)	1.94001105
53	Aplasia involving forearm bones (HP:0009822)	1.94001105
54	Abnormality of the pancreatic islet cells (HP:0006476)	1.92415920
55	Abnormality of endocrine pancreas physiology (HP:0012093)	1.92415920
56	Coronal craniosynostosis (HP:0004440)	1.91682423
57	Absent radius (HP:0003974)	1.91421572
58	Long foot (HP:0001833)	1.91212775
59	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.90451581
60	Oligomenorrhea (HP:0000876)	1.89980301
61	Cutaneous syndactyly (HP:0012725)	1.88492073
62	Partial duplication of thumb phalanx (HP:0009944)	1.88456695
63	Abnormality of the clitoris (HP:0000056)	1.87858280
64	Short hallux (HP:0010109)	1.87349010
65	Abnormality of the lacrimal duct (HP:0011481)	1.87262597
66	Back pain (HP:0003418)	1.86942647
67	Rimmed vacuoles (HP:0003805)	1.85367319
68	Hypoplastic female external genitalia (HP:0012815)	1.84756006
69	Narrow nasal bridge (HP:0000446)	1.84618406
70	Abnormality of the salivary glands (HP:0010286)	1.83361801
71	Poor suck (HP:0002033)	1.82387244
72	Hypoglycemic seizures (HP:0002173)	1.81984839
73	Intestinal fistula (HP:0100819)	1.81100874
74	Cellular immunodeficiency (HP:0005374)	1.80037241
75	Omphalocele (HP:0001539)	1.79545045
76	Labial hypoplasia (HP:0000066)	1.77709467
77	Increased nuchal translucency (HP:0010880)	1.77233046
78	Turricephaly (HP:0000262)	1.77112534
79	Skull defect (HP:0001362)	1.77031774
80	Abnormality of the septum pellucidum (HP:0007375)	1.76813695
81	Cutaneous finger syndactyly (HP:0010554)	1.75924818
82	Atonic seizures (HP:0010819)	1.75593178
83	Esophageal atresia (HP:0002032)	1.75277014
84	Buphthalmos (HP:0000557)	1.74870191
85	Diaphragmatic weakness (HP:0009113)	1.74355734
86	Rhabdomyosarcoma (HP:0002859)	1.73760680
87	Hip dysplasia (HP:0001385)	1.73103515
88	Neoplasm of the adrenal cortex (HP:0100641)	1.72638354
89	Gastrointestinal carcinoma (HP:0002672)	1.71083570
90	Malignant gastrointestinal tract tumors (HP:0006749)	1.71083570
91	Renovascular hypertension (HP:0100817)	1.70720994
92	Rib fusion (HP:0000902)	1.70445378
93	Myelomeningocele (HP:0002475)	1.68925790
94	Neonatal hypoglycemia (HP:0001998)	1.68889373
95	Aplasia involving bones of the extremities (HP:0009825)	1.68224465
96	Aplasia involving bones of the upper limbs (HP:0009823)	1.68224465
97	Aplasia of the phalanges of the hand (HP:0009802)	1.68224465
98	Abnormality of homocysteine metabolism (HP:0010919)	1.68063966
99	Homocystinuria (HP:0002156)	1.68063966
100	Vaginal fistula (HP:0004320)	1.66624341

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	3.64667610
2	BUB1	2.94780712
3	CDK12	2.84155281
4	PLK4	2.76289953
5	FGFR4	2.71957387
6	MAPKAPK5	2.67980641
7	VRK2	2.52777486
8	TSSK6	2.49853410
9	TTK	2.30347133
10	CAMK1G	2.24900529
11	MAP3K12	2.12807262
12	SRPK1	2.12313505
13	CAMK1D	2.08734452
14	SIK2	2.05253637
15	CDK19	1.94857447
16	MAP3K10	1.86209140
17	EPHA3	1.80705175
18	MKNK1	1.77025727
19	MKNK2	1.71166612
20	SMG1	1.67481990
21	DYRK2	1.66840497
22	TYRO3	1.66022241
23	BRD4	1.65820936
24	PASK	1.57038786
25	NLK	1.53889953
26	TESK2	1.47734978
27	EEF2K	1.44468252
28	ALK	1.36355937
29	SIK3	1.35851014
30	PNCK	1.32374649
31	MAP3K9	1.29777460
32	STK16	1.29546782
33	PLK3	1.27174421
34	MAP3K13	1.19923762
35	BCR	1.18688046
36	NUAK1	1.18591915
37	OXSR1	1.15806303
38	ATR	1.11595879
39	FGFR1	1.08917614
40	MAP4K2	1.05957914
41	CHEK2	1.05116389
42	LATS1	0.99367060
43	TAF1	0.99022516
44	ZAK	0.98719015
45	EIF2AK3	0.97988559
46	FGFR2	0.97417618
47	TXK	0.92754329
48	MAP3K11	0.88879600
49	PLK1	0.88451149
50	EPHB1	0.87806123
51	PINK1	0.86004294
52	STK38L	0.84058171
53	NEK2	0.83911471
54	VRK1	0.82042479
55	CSNK1G1	0.81466949
56	ATM	0.77658068
57	BMX	0.75283141
58	RPS6KA5	0.72850861
59	DMPK	0.72629263
60	LATS2	0.71790405
61	STK3	0.71034466
62	CHEK1	0.69687754
63	MTOR	0.68739905
64	PIM1	0.66969680
65	BRSK2	0.65738459
66	AURKB	0.64977045
67	KDR	0.63602778
68	BCKDK	0.62984526
69	ARAF	0.62034578
70	RAF1	0.61298748
71	TLK1	0.60417079
72	CDK2	0.60210715
73	CDK4	0.57879016
74	CDK7	0.57046843
75	NME1	0.56790106
76	TEC	0.56376431
77	MAP2K2	0.56129877
78	ERBB4	0.56035715
79	CDK1	0.52706235
80	CSNK1G3	0.51554142
81	PRKDC	0.51068938
82	BRSK1	0.50279049
83	PLK2	0.49123510
84	IRAK1	0.48826931
85	SIK1	0.48190916
86	TNIK	0.43425356
87	PAK4	0.42277574
88	MAPK10	0.41748936
89	MAPK9	0.41695935
90	TIE1	0.41215808
91	PAK3	0.40671345
92	NEK1	0.40565545
93	FER	0.40431763
94	CSNK1E	0.40272660
95	DAPK1	0.39971306
96	RPS6KA1	0.38778055
97	PRKCZ	0.38549330
98	CSNK1G2	0.38061999
99	GSK3B	0.37024713
100	MAP3K1	0.36974130

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	4.05490890
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.98161323
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.59118211
4	DNA replication_Homo sapiens_hsa03030	2.96397460
5	Mismatch repair_Homo sapiens_hsa03430	2.81265748
6	RNA polymerase_Homo sapiens_hsa03020	2.78582273
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.73960260
8	Spliceosome_Homo sapiens_hsa03040	2.70068153
9	RNA transport_Homo sapiens_hsa03013	2.53249351
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.41992882
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.40960029
12	mRNA surveillance pathway_Homo sapiens_hsa03015	2.31535379
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.24765105
14	Base excision repair_Homo sapiens_hsa03410	2.09355169
15	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.94573422
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.93844255
17	Basal transcription factors_Homo sapiens_hsa03022	1.90352712
18	Cell cycle_Homo sapiens_hsa04110	1.76692042
19	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.62371773
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.56694173
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.48828282
22	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.48216719
23	One carbon pool by folate_Homo sapiens_hsa00670	1.47315690
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.43733085
25	Lysine degradation_Homo sapiens_hsa00310	1.40379878
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.36945300
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.35953945
28	Phototransduction_Homo sapiens_hsa04744	1.35179763
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.33556365
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31483297
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.26386187
32	Adherens junction_Homo sapiens_hsa04520	1.25451137
33	Arginine and proline metabolism_Homo sapiens_hsa00330	1.17850847
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14069090
35	Arginine biosynthesis_Homo sapiens_hsa00220	1.10224474
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.08160876
37	RNA degradation_Homo sapiens_hsa03018	1.07583190
38	Tight junction_Homo sapiens_hsa04530	1.05537618
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.00683711
40	Hippo signaling pathway_Homo sapiens_hsa04390	1.00050297
41	Carbon metabolism_Homo sapiens_hsa01200	0.96870735
42	Homologous recombination_Homo sapiens_hsa03440	0.96521019
43	Purine metabolism_Homo sapiens_hsa00230	0.96107802
44	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.93036812
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91040726
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.88740141
47	Basal cell carcinoma_Homo sapiens_hsa05217	0.87718394
48	Wnt signaling pathway_Homo sapiens_hsa04310	0.85712920
49	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.84010006
50	Oocyte meiosis_Homo sapiens_hsa04114	0.78229572
51	Huntingtons disease_Homo sapiens_hsa05016	0.78069398
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76090718
53	Thyroid cancer_Homo sapiens_hsa05216	0.74291983
54	Proteasome_Homo sapiens_hsa03050	0.73361144
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70058003
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66163369
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65632295
58	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.63377651
59	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.59769263
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59644060
61	Nicotine addiction_Homo sapiens_hsa05033	0.59642722
62	MicroRNAs in cancer_Homo sapiens_hsa05206	0.57841634
63	Alcoholism_Homo sapiens_hsa05034	0.53839143
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53613440
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.51571761
66	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.51381563
67	p53 signaling pathway_Homo sapiens_hsa04115	0.50690103
68	Folate biosynthesis_Homo sapiens_hsa00790	0.50399429
69	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.50306438
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.49852036
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46459990
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.44552132
73	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43573169
74	Sulfur relay system_Homo sapiens_hsa04122	0.42535282
75	Phenylalanine metabolism_Homo sapiens_hsa00360	0.42145631
76	Metabolic pathways_Homo sapiens_hsa01100	0.42067134
77	Taste transduction_Homo sapiens_hsa04742	0.40952656
78	Retinol metabolism_Homo sapiens_hsa00830	0.40542699
79	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.39139398
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.38196132
81	Galactose metabolism_Homo sapiens_hsa00052	0.37309087
82	Sulfur metabolism_Homo sapiens_hsa00920	0.36868379
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34288560
84	Fatty acid elongation_Homo sapiens_hsa00062	0.32379630
85	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.29777732
86	Cardiac muscle contraction_Homo sapiens_hsa04260	0.29353984
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.28919365
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.27274991
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.25974518
90	Propanoate metabolism_Homo sapiens_hsa00640	0.22690941
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.20932998
92	AMPK signaling pathway_Homo sapiens_hsa04152	0.20618949
93	Viral carcinogenesis_Homo sapiens_hsa05203	0.20019479
94	Colorectal cancer_Homo sapiens_hsa05210	0.19925650
95	Long-term depression_Homo sapiens_hsa04730	0.17379002
96	Insulin signaling pathway_Homo sapiens_hsa04910	0.16404337
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.15975631
98	Endometrial cancer_Homo sapiens_hsa05213	0.15729557
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.15651300
100	Glutathione metabolism_Homo sapiens_hsa00480	0.14019937

FAM220CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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