FAM221A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.12089259
2piRNA metabolic process (GO:0034587)5.50059984
3response to pheromone (GO:0019236)4.67410365
4indole-containing compound catabolic process (GO:0042436)4.60435451
5indolalkylamine catabolic process (GO:0046218)4.60435451
6tryptophan catabolic process (GO:0006569)4.60435451
7L-fucose catabolic process (GO:0042355)4.58725075
8fucose catabolic process (GO:0019317)4.58725075
9L-fucose metabolic process (GO:0042354)4.58725075
10kynurenine metabolic process (GO:0070189)4.54121569
11meiotic chromosome segregation (GO:0045132)4.50662514
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.50376306
13attachment of spindle microtubules to kinetochore (GO:0008608)4.17737428
14indolalkylamine metabolic process (GO:0006586)4.15804765
15DNA methylation involved in gamete generation (GO:0043046)4.14681093
16mitotic metaphase plate congression (GO:0007080)4.09903287
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.96276888
18protein localization to kinetochore (GO:0034501)3.96063594
19DNA replication checkpoint (GO:0000076)3.94719129
20tryptophan metabolic process (GO:0006568)3.94507976
21maturation of SSU-rRNA (GO:0030490)3.89426433
22chromatin remodeling at centromere (GO:0031055)3.82716403
23cellular ketone body metabolic process (GO:0046950)3.79457743
24protein K6-linked ubiquitination (GO:0085020)3.79032896
25epithelial cilium movement (GO:0003351)3.78083040
26CENP-A containing nucleosome assembly (GO:0034080)3.77402421
27DNA deamination (GO:0045006)3.75607103
28telomere maintenance via recombination (GO:0000722)3.74697186
29DNA replication initiation (GO:0006270)3.70581161
30DNA replication-independent nucleosome organization (GO:0034724)3.69625988
31DNA replication-independent nucleosome assembly (GO:0006336)3.69625988
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.65111634
33metaphase plate congression (GO:0051310)3.63434704
34mitotic chromosome condensation (GO:0007076)3.59226488
35telomere maintenance via semi-conservative replication (GO:0032201)3.59192424
36DNA strand elongation involved in DNA replication (GO:0006271)3.58980402
37synaptonemal complex assembly (GO:0007130)3.55688085
38DNA synthesis involved in DNA repair (GO:0000731)3.54964025
39meiotic cell cycle (GO:0051321)3.53410143
40axonemal dynein complex assembly (GO:0070286)3.50371216
41cilium movement (GO:0003341)3.48124695
42mitotic recombination (GO:0006312)3.47736163
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47646979
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47646979
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.47646979
46kinetochore organization (GO:0051383)3.46309924
47synaptonemal complex organization (GO:0070193)3.45070672
48negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.44159206
49negative regulation of DNA-templated transcription, elongation (GO:0032785)3.44159206
50histone exchange (GO:0043486)3.41982341
51intestinal epithelial cell development (GO:0060576)3.41353454
52positive regulation of chromosome segregation (GO:0051984)3.41102225
53ketone body metabolic process (GO:1902224)3.40521342
54DNA strand elongation (GO:0022616)3.38299473
55protein localization to chromosome, centromeric region (GO:0071459)3.36418060
56axoneme assembly (GO:0035082)3.31688054
57water-soluble vitamin biosynthetic process (GO:0042364)3.30910685
58indole-containing compound metabolic process (GO:0042430)3.29237336
59detection of light stimulus involved in sensory perception (GO:0050962)3.25787897
60detection of light stimulus involved in visual perception (GO:0050908)3.25787897
61regulation of cilium movement (GO:0003352)3.24522633
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24189657
63male meiosis (GO:0007140)3.22363847
64kinetochore assembly (GO:0051382)3.22134233
65interferon-gamma secretion (GO:0072643)3.19686067
66maturation of 5.8S rRNA (GO:0000460)3.19112399
67nonmotile primary cilium assembly (GO:0035058)3.17589132
68sulfation (GO:0051923)3.17010814
69centriole assembly (GO:0098534)3.16570489
70mitotic sister chromatid segregation (GO:0000070)3.15457306
71regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14079018
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.13941465
73proteasome assembly (GO:0043248)3.13531689
74telomere maintenance via telomere lengthening (GO:0010833)3.12987983
75neural tube formation (GO:0001841)3.11868738
76establishment of chromosome localization (GO:0051303)3.09174590
77male meiosis I (GO:0007141)3.08271456
78amine catabolic process (GO:0009310)3.06930540
79cellular biogenic amine catabolic process (GO:0042402)3.06930540
80nephron tubule morphogenesis (GO:0072078)3.06230662
81nephron epithelium morphogenesis (GO:0072088)3.06230662
82DNA replication-dependent nucleosome assembly (GO:0006335)3.05610423
83DNA replication-dependent nucleosome organization (GO:0034723)3.05610423
84meiotic nuclear division (GO:0007126)3.05135155
85regulation of meiosis I (GO:0060631)3.04326797
86protein localization to chromosome (GO:0034502)3.03078800
87chromosome segregation (GO:0007059)3.02819077
88regulation of sister chromatid cohesion (GO:0007063)3.02738240
89oocyte maturation (GO:0001556)3.02604563
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02568765
91rRNA modification (GO:0000154)3.01907237
92nucleotide-excision repair, DNA gap filling (GO:0006297)2.99841110
93negative regulation of telomere maintenance (GO:0032205)2.99659986
94meiotic cell cycle process (GO:1903046)2.99445873
95reciprocal meiotic recombination (GO:0007131)2.98304006
96reciprocal DNA recombination (GO:0035825)2.98304006
97chromosome organization involved in meiosis (GO:0070192)2.97731165
98meiosis I (GO:0007127)2.97197214
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96661202
100mitotic nuclear envelope disassembly (GO:0007077)2.95891643
101ribosomal large subunit biogenesis (GO:0042273)2.95605976
102regulation of chromosome segregation (GO:0051983)2.94634325
103spindle checkpoint (GO:0031577)2.94305268
104gamma-aminobutyric acid transport (GO:0015812)2.94004722
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93594464
106respiratory chain complex IV assembly (GO:0008535)2.93095381
107mitotic sister chromatid cohesion (GO:0007064)2.91978338
108regulation of hippo signaling (GO:0035330)2.90845092
109neuronal action potential (GO:0019228)2.90666668
110reflex (GO:0060004)2.89960582
111ribosomal small subunit biogenesis (GO:0042274)2.89903333
112telomere maintenance (GO:0000723)2.88530381
113regulation of female gonad development (GO:2000194)2.88496374
114purine nucleobase biosynthetic process (GO:0009113)2.86278443
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85553639
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.85553639
117kidney morphogenesis (GO:0060993)2.85064594
118cilium morphogenesis (GO:0060271)2.85043265
119cilium organization (GO:0044782)2.84938427
120negative regulation of chromosome segregation (GO:0051985)2.84904531
121telomere organization (GO:0032200)2.84847753
122regulation of sister chromatid segregation (GO:0033045)2.84660836
123regulation of mitotic sister chromatid separation (GO:0010965)2.84660836
124regulation of mitotic sister chromatid segregation (GO:0033047)2.84660836
125regulation of histone H3-K27 methylation (GO:0061085)2.84366670
126nuclear pore organization (GO:0006999)2.82582059
127cilium or flagellum-dependent cell motility (GO:0001539)2.82249637
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81476743
129mitotic spindle checkpoint (GO:0071174)2.80847612
130protein complex biogenesis (GO:0070271)2.80833773
131negative regulation of sister chromatid segregation (GO:0033046)2.79524027
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.79524027
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79524027
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79524027
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.79292702
136retinal cone cell development (GO:0046549)2.79099469
137regulation of posttranscriptional gene silencing (GO:0060147)2.78868292
138regulation of gene silencing by miRNA (GO:0060964)2.78868292
139regulation of gene silencing by RNA (GO:0060966)2.78868292
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78821074
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.78821074
142NADH dehydrogenase complex assembly (GO:0010257)2.78821074
143cornea development in camera-type eye (GO:0061303)2.78600124
144behavioral response to ethanol (GO:0048149)2.77496896
145spinal cord motor neuron differentiation (GO:0021522)2.77169592
146signal peptide processing (GO:0006465)2.76677503
147membrane disassembly (GO:0030397)2.76677232
148nuclear envelope disassembly (GO:0051081)2.76677232
149negative regulation of meiosis (GO:0045835)2.75578287
150keratinocyte development (GO:0003334)2.74559408
151cilium assembly (GO:0042384)2.74419883
152sister chromatid cohesion (GO:0007062)2.73913792
153platelet dense granule organization (GO:0060155)2.73853145
154negative regulation of translation, ncRNA-mediated (GO:0040033)2.73467332
155regulation of translation, ncRNA-mediated (GO:0045974)2.73467332
156negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73467332
157primary amino compound metabolic process (GO:1901160)2.72457158
158NAD biosynthetic process (GO:0009435)2.72099461
159protein localization to cilium (GO:0061512)2.71721329
160replication fork processing (GO:0031297)2.71064271
161preassembly of GPI anchor in ER membrane (GO:0016254)2.70646486
162photoreceptor cell maintenance (GO:0045494)2.69352497
163negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68126244
164drug catabolic process (GO:0042737)2.67016416
165protein polyglutamylation (GO:0018095)2.66451621
166membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.65749126
167oxidative demethylation (GO:0070989)2.64406597
168mitochondrial respiratory chain complex assembly (GO:0033108)2.63524057
169serotonin metabolic process (GO:0042428)2.62014870
170benzene-containing compound metabolic process (GO:0042537)2.61545488
171aromatic amino acid family catabolic process (GO:0009074)2.60517540
172regulation of action potential (GO:0098900)2.59668942
173cytochrome complex assembly (GO:0017004)2.56043520
174regulation of mesoderm development (GO:2000380)2.55806747
175negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54409880
176recombinational repair (GO:0000725)2.53896130
177exogenous drug catabolic process (GO:0042738)2.53026987
178double-strand break repair via homologous recombination (GO:0000724)2.52401621
179RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52014688
180protein-cofactor linkage (GO:0018065)2.51274784
181negative regulation of mast cell activation (GO:0033004)2.50545936
182rRNA catabolic process (GO:0016075)2.50451195
183regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49956491
184membrane repolarization during action potential (GO:0086011)2.49733143
185membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48862459
186auditory receptor cell stereocilium organization (GO:0060088)2.48841767
187positive regulation of oligodendrocyte differentiation (GO:0048714)2.48750920
188G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47643079
189photoreceptor cell development (GO:0042461)2.46770856
190rhodopsin mediated signaling pathway (GO:0016056)2.46651475
191detection of mechanical stimulus involved in sensory perception (GO:0050974)2.45744789
192synaptic transmission, cholinergic (GO:0007271)2.44209638
193positive regulation of fatty acid transport (GO:2000193)2.43994164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.84455694
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60078547
3ZNF274_21170338_ChIP-Seq_K562_Hela4.09496078
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.93613533
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.72255372
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67502570
7VDR_22108803_ChIP-Seq_LS180_Human3.47770791
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30943703
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29944084
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.21732551
11EZH2_22144423_ChIP-Seq_EOC_Human3.11291700
12GBX2_23144817_ChIP-Seq_PC3_Human3.05279507
13AR_21909140_ChIP-Seq_LNCAP_Human2.99130013
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.92399009
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.88595589
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87738767
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.79458735
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54952262
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54722422
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46836900
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.44723874
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41803522
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39248209
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26977922
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25174187
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24421860
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22571621
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22009506
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20774260
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19014669
31EWS_26573619_Chip-Seq_HEK293_Human2.16947481
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.14717976
33VDR_23849224_ChIP-Seq_CD4+_Human2.11306503
34CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08917632
35FUS_26573619_Chip-Seq_HEK293_Human2.06415608
36IGF1R_20145208_ChIP-Seq_DFB_Human2.04782819
37P300_19829295_ChIP-Seq_ESCs_Human2.03944816
38NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03631909
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98480561
40TAF15_26573619_Chip-Seq_HEK293_Human1.96374686
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94991078
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93894752
43ER_23166858_ChIP-Seq_MCF-7_Human1.92451651
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88975272
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.88372717
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85628454
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82898683
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82166289
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80518231
50DCP1A_22483619_ChIP-Seq_HELA_Human1.80479892
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72135192
52XRN2_22483619_ChIP-Seq_HELA_Human1.70743832
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70215743
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.69425465
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69144915
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67523576
57FOXP3_21729870_ChIP-Seq_TREG_Human1.62048309
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61737981
59BCAT_22108803_ChIP-Seq_LS180_Human1.61295053
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60311767
61STAT3_23295773_ChIP-Seq_U87_Human1.60209486
62TTF2_22483619_ChIP-Seq_HELA_Human1.59241625
63GABP_19822575_ChIP-Seq_HepG2_Human1.59148115
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57927709
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56791837
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54905144
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54364332
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53655981
69ELK1_19687146_ChIP-ChIP_HELA_Human1.51075320
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49456326
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49456326
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49408479
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48799624
74REST_21632747_ChIP-Seq_MESCs_Mouse1.47511922
75SMAD4_21799915_ChIP-Seq_A2780_Human1.47220922
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47205200
77AR_25329375_ChIP-Seq_VCAP_Human1.47153583
78TCF4_23295773_ChIP-Seq_U87_Human1.46530685
79TP53_22573176_ChIP-Seq_HFKS_Human1.45524157
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45347857
81CBP_20019798_ChIP-Seq_JUKART_Human1.45070585
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45070585
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44362808
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43808160
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40788913
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39824304
87KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39612854
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38868706
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38239048
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37800695
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.36778315
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36778315
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35470066
94AR_21572438_ChIP-Seq_LNCaP_Human1.35462274
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.35072096
96SOX2_19829295_ChIP-Seq_ESCs_Human1.33672644
97NANOG_19829295_ChIP-Seq_ESCs_Human1.33672644
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.32462029
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31167878
100TCF4_22108803_ChIP-Seq_LS180_Human1.29944925
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.27768165
102RUNX2_22187159_ChIP-Seq_PCA_Human1.27498687
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25784564
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24210893
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23662358
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23470017
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.22128362
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21262669
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20991969
110MYC_18940864_ChIP-ChIP_HL60_Human1.20099125
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19599634
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.19009753
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.18884347
114RNF2_27304074_Chip-Seq_NSC_Mouse1.18210340
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.16998410
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16985305
117ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16746212
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16237113
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.16034743
120NCOR_22424771_ChIP-Seq_293T_Human1.15903328
121AR_20517297_ChIP-Seq_VCAP_Human1.15666606
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15217571
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.14981799
124ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14424445
125HOXB7_26014856_ChIP-Seq_BT474_Human1.13847630
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.12147518
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12122880
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11755002
129SRF_21415370_ChIP-Seq_HL-1_Mouse1.10468101
130KDM5A_27292631_Chip-Seq_BREAST_Human1.10030453
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08772710
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08574447
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08442723
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08304726
135CIITA_25753668_ChIP-Seq_RAJI_Human1.05979197
136TP53_16413492_ChIP-PET_HCT116_Human1.04994811
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00877385
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00628778
139DROSHA_22980978_ChIP-Seq_HELA_Human0.99483319
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.99009765
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98868856
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.98825998
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97880660
144P53_22387025_ChIP-Seq_ESCs_Mouse0.97365883
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97362462
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97020622
147CDX2_22108803_ChIP-Seq_LS180_Human0.96319447
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95170954
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94080488
150MYC_19829295_ChIP-Seq_ESCs_Human0.92961866
151TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.92828632
152GATA1_26923725_Chip-Seq_HPCs_Mouse0.91892404
153THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91664161
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.91534339
155EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91324545
156CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91181534
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.91116064
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90981508
159SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90688636
160RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89744247
161ESR1_21235772_ChIP-Seq_MCF-7_Human0.86957693
162TFEB_21752829_ChIP-Seq_HELA_Human0.84883965
163FLI1_27457419_Chip-Seq_LIVER_Mouse0.84588544
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84348865
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84317655
166IRF1_19129219_ChIP-ChIP_H3396_Human0.83385651
167TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80352414
168SALL1_21062744_ChIP-ChIP_HESCs_Human0.79258543
169POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79240428
170CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79012669
171ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78264356
172ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77842579
173PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.74649120
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73431260
175HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72802649
176NANOG_21062744_ChIP-ChIP_HESCs_Human0.71154555
177PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70636359
178KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69587603
179ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67479061
180EGR1_19374776_ChIP-ChIP_THP-1_Human0.67421911
181PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66226936
182CHD1_26751641_Chip-Seq_LNCaP_Human0.65854121
183KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.65837244
184POU5F1_16153702_ChIP-ChIP_HESCs_Human0.65469004
185STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65279398
186NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.64979673
187FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64318547
188SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.61671919
189SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.61419422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.49052237
2MP0010094_abnormal_chromosome_stability3.97010574
3MP0008057_abnormal_DNA_replication3.75095425
4MP0003111_abnormal_nucleus_morphology3.53115757
5MP0004957_abnormal_blastocyst_morpholog3.45314590
6MP0003718_maternal_effect3.22536190
7MP0003195_calcinosis3.06691574
8MP0008877_abnormal_DNA_methylation3.03179316
9MP0003077_abnormal_cell_cycle2.90031343
10MP0008058_abnormal_DNA_repair2.81122008
11MP0003136_yellow_coat_color2.78529323
12MP0003941_abnormal_skin_development2.70343205
13MP0000569_abnormal_digit_pigmentation2.49927440
14MP0005551_abnormal_eye_electrophysiolog2.41838586
15MP0003878_abnormal_ear_physiology2.41590620
16MP0005377_hearing/vestibular/ear_phenot2.41590620
17MP0002102_abnormal_ear_morphology2.36922058
18MP0003786_premature_aging2.30018287
19MP0001968_abnormal_touch/_nociception2.29423309
20MP0004043_abnormal_pH_regulation2.27448983
21MP0009046_muscle_twitch2.25423078
22MP0001485_abnormal_pinna_reflex2.23917460
23MP0008932_abnormal_embryonic_tissue2.10249966
24MP0005451_abnormal_body_composition2.10125555
25MP0009745_abnormal_behavioral_response2.05940605
26MP0008007_abnormal_cellular_replicative2.04966918
27MP0004142_abnormal_muscle_tone1.98406629
28MP0000490_abnormal_crypts_of1.95182762
29MP0002210_abnormal_sex_determination1.94722102
30MP0008872_abnormal_physiological_respon1.94634582
31MP0008875_abnormal_xenobiotic_pharmacok1.93815683
32MP0001501_abnormal_sleep_pattern1.92047542
33MP0001929_abnormal_gametogenesis1.81576010
34MP0002736_abnormal_nociception_after1.81057101
35MP0002876_abnormal_thyroid_physiology1.77802579
36MP0005645_abnormal_hypothalamus_physiol1.72785596
37MP0003123_paternal_imprinting1.70893293
38MP0002638_abnormal_pupillary_reflex1.69327519
39MP0002272_abnormal_nervous_system1.68732437
40MP0002796_impaired_skin_barrier1.63952335
41MP0005253_abnormal_eye_physiology1.62717764
42MP0001119_abnormal_female_reproductive1.62246320
43MP0003315_abnormal_perineum_morphology1.62209478
44MP0002163_abnormal_gland_morphology1.61668568
45MP0004147_increased_porphyrin_level1.61525551
46MP0004133_heterotaxia1.60034440
47MP0002938_white_spotting1.59994729
48MP0003880_abnormal_central_pattern1.59942958
49MP0000653_abnormal_sex_gland1.59858547
50MP0002132_abnormal_respiratory_system1.58500118
51MP0002837_dystrophic_cardiac_calcinosis1.57681767
52MP0002277_abnormal_respiratory_mucosa1.56206783
53MP0005646_abnormal_pituitary_gland1.55220399
54MP0001486_abnormal_startle_reflex1.55182415
55MP0004782_abnormal_surfactant_physiolog1.54133221
56MP0001145_abnormal_male_reproductive1.52375706
57MP0005395_other_phenotype1.51744067
58MP0002064_seizures1.48868819
59MP0000350_abnormal_cell_proliferation1.48549685
60MP0010352_gastrointestinal_tract_polyps1.47647657
61MP0005174_abnormal_tail_pigmentation1.45245628
62MP0002928_abnormal_bile_duct1.43311334
63MP0000566_synostosis1.43058960
64MP0000631_abnormal_neuroendocrine_gland1.42838447
65MP0002098_abnormal_vibrissa_morphology1.42410539
66MP0006276_abnormal_autonomic_nervous1.41610094
67MP0004742_abnormal_vestibular_system1.41091403
68MP0008260_abnormal_autophagy1.40891630
69MP0008995_early_reproductive_senescence1.40692205
70MP0004885_abnormal_endolymph1.40331205
71MP0004145_abnormal_muscle_electrophysio1.39279551
72MP0005084_abnormal_gallbladder_morpholo1.38814427
73MP0003763_abnormal_thymus_physiology1.36159110
74MP0002735_abnormal_chemical_nociception1.35432236
75MP0002572_abnormal_emotion/affect_behav1.34912946
76MP0005367_renal/urinary_system_phenotyp1.33044866
77MP0000516_abnormal_urinary_system1.33044866
78MP0002067_abnormal_sensory_capabilities1.26159468
79MP0004215_abnormal_myocardial_fiber1.24834669
80MP0001970_abnormal_pain_threshold1.21946749
81MP0003011_delayed_dark_adaptation1.21238071
82MP0002557_abnormal_social/conspecific_i1.20268205
83MP0005408_hypopigmentation1.18720244
84MP0003121_genomic_imprinting1.15678531
85MP0005501_abnormal_skin_physiology1.15647719
86MP0008004_abnormal_stomach_pH1.14666584
87MP0002733_abnormal_thermal_nociception1.13137816
88MP0000678_abnormal_parathyroid_gland1.12924312
89MP0001984_abnormal_olfaction1.12729715
90MP0005085_abnormal_gallbladder_physiolo1.12305525
91MP0003698_abnormal_male_reproductive1.12219230
92MP0006292_abnormal_olfactory_placode1.12031320
93MP0009697_abnormal_copulation1.11792735
94MP0003137_abnormal_impulse_conducting1.10849448
95MP0000383_abnormal_hair_follicle1.10643718
96MP0002396_abnormal_hematopoietic_system1.10026612
97MP0001730_embryonic_growth_arrest1.09214448
98MP0004924_abnormal_behavior1.08188095
99MP0005386_behavior/neurological_phenoty1.08188095
100MP0001697_abnormal_embryo_size1.07879167
101MP0001919_abnormal_reproductive_system1.07240260
102MP0003635_abnormal_synaptic_transmissio1.05254760
103MP0002063_abnormal_learning/memory/cond1.05090051
104MP0004381_abnormal_hair_follicle1.04855390
105MP0003283_abnormal_digestive_organ1.04557296
106MP0002060_abnormal_skin_morphology1.03914422
107MP0003699_abnormal_female_reproductive1.02757887
108MP0002019_abnormal_tumor_incidence1.01263959
109MP0005389_reproductive_system_phenotype1.00932214
110MP0000026_abnormal_inner_ear1.00844992
111MP0005195_abnormal_posterior_eye1.00837016
112MP0001216_abnormal_epidermal_layer1.00269917
113MP0002249_abnormal_larynx_morphology1.00188480
114MP0005167_abnormal_blood-brain_barrier0.98016246
115MP0002085_abnormal_embryonic_tissue0.97196947
116MP0010307_abnormal_tumor_latency0.96996099
117MP0000313_abnormal_cell_death0.95598462
118MP0001672_abnormal_embryogenesis/_devel0.95582047
119MP0005380_embryogenesis_phenotype0.95582047
120MP0010234_abnormal_vibrissa_follicle0.94817549
121MP0005379_endocrine/exocrine_gland_phen0.94453718
122MP0002138_abnormal_hepatobiliary_system0.93963375
123MP0000613_abnormal_salivary_gland0.93298274
124MP0003787_abnormal_imprinting0.92898515
125MP0004264_abnormal_extraembryonic_tissu0.92505245
126MP0001346_abnormal_lacrimal_gland0.91206559
127MP0001529_abnormal_vocalization0.90522463
128MP0002234_abnormal_pharynx_morphology0.89665675
129MP0002229_neurodegeneration0.89014536
130MP0000372_irregular_coat_pigmentation0.88940872
131MP0002752_abnormal_somatic_nervous0.88639986
132MP0002734_abnormal_mechanical_nocicepti0.88566995
133MP0001963_abnormal_hearing_physiology0.88219845
134MP0000230_abnormal_systemic_arterial0.87738713
135MP0002160_abnormal_reproductive_system0.87501161
136MP0003252_abnormal_bile_duct0.87448769
137MP0003890_abnormal_embryonic-extraembry0.87344096
138MP0010678_abnormal_skin_adnexa0.87218098
139MP0002161_abnormal_fertility/fecundity0.86375844
140MP0004808_abnormal_hematopoietic_stem0.85051407
141MP0006072_abnormal_retinal_apoptosis0.83350708
142MP0002084_abnormal_developmental_patter0.83310370
143MP0005410_abnormal_fertilization0.82784614
144MP0003937_abnormal_limbs/digits/tail_de0.82073137
145MP0003119_abnormal_digestive_system0.81987636
146MP0005332_abnormal_amino_acid0.81885927
147MP0000538_abnormal_urinary_bladder0.81596094
148MP0001905_abnormal_dopamine_level0.79764692
149MP0005075_abnormal_melanosome_morpholog0.79539170
150MP0010030_abnormal_orbit_morphology0.78677824
151MP0005647_abnormal_sex_gland0.78673859
152MP0002009_preneoplasia0.77913478
153MP0002095_abnormal_skin_pigmentation0.77482446
154MP0002080_prenatal_lethality0.76920078
155MP0001324_abnormal_eye_pigmentation0.76182250
156MP0002184_abnormal_innervation0.75441358
157MP0001293_anophthalmia0.75030020
158MP0002751_abnormal_autonomic_nervous0.73971208
159MP0003646_muscle_fatigue0.73903408
160MP0005076_abnormal_cell_differentiation0.73827135
161MP0000465_gastrointestinal_hemorrhage0.73719223
162MP0005220_abnormal_exocrine_pancreas0.73280981
163MP0001502_abnormal_circadian_rhythm0.73033235
164MP0005448_abnormal_energy_balance0.72390874
165MP0003984_embryonic_growth_retardation0.72280943
166MP0002653_abnormal_ependyma_morphology0.72124198
167MP0000778_abnormal_nervous_system0.71971700
168MP0002088_abnormal_embryonic_growth/wei0.70174944
169MP0000477_abnormal_intestine_morphology0.69416150
170MP0010386_abnormal_urinary_bladder0.68436333
171MP0000377_abnormal_hair_follicle0.67337369
172MP0002086_abnormal_extraembryonic_tissu0.67031102
173MP0000427_abnormal_hair_cycle0.66076810
174MP0010771_integument_phenotype0.65974317
175MP0001986_abnormal_taste_sensitivity0.65580708
176MP0009333_abnormal_splenocyte_physiolog0.63639058
177MP0000703_abnormal_thymus_morphology0.63101016

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.47669211
2Chronic bronchitis (HP:0004469)5.36320598
3Abnormal respiratory motile cilium physiology (HP:0012261)4.20286276
4Chromsome breakage (HP:0040012)4.11284667
5Oligodactyly (hands) (HP:0001180)4.10210753
6Birth length less than 3rd percentile (HP:0003561)4.09380079
7Breast hypoplasia (HP:0003187)4.04739967
8Congenital stationary night blindness (HP:0007642)3.94722884
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83701521
10Rhinitis (HP:0012384)3.83188674
11Male infertility (HP:0003251)3.76371114
12Nephronophthisis (HP:0000090)3.68468560
13Abnormal ciliary motility (HP:0012262)3.49370929
14Oligodactyly (HP:0012165)3.48578815
15Bronchiectasis (HP:0002110)3.47927083
16Hyperventilation (HP:0002883)3.32304495
17Abnormality of the renal cortex (HP:0011035)3.29548417
18Abnormality of the renal medulla (HP:0100957)3.26571806
19Reticulocytopenia (HP:0001896)3.22357576
20Carpal bone hypoplasia (HP:0001498)3.13087812
21Abnormal respiratory motile cilium morphology (HP:0005938)3.12532292
22Abnormal respiratory epithelium morphology (HP:0012253)3.12532292
23Abnormality of chromosome stability (HP:0003220)3.06152907
24Cystic liver disease (HP:0006706)3.01221257
25Type II lissencephaly (HP:0007260)2.96467524
26Supernumerary spleens (HP:0009799)2.91823080
27Ectopic kidney (HP:0000086)2.91580047
28Hyperalaninemia (HP:0003348)2.89448263
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.89448263
30Abnormality of alanine metabolism (HP:0010916)2.89448263
31Medial flaring of the eyebrow (HP:0010747)2.87843042
32Chronic hepatic failure (HP:0100626)2.87690125
33Absent thumb (HP:0009777)2.87589126
34Attenuation of retinal blood vessels (HP:0007843)2.87364488
35Abnormality of the preputium (HP:0100587)2.80311408
36Large for gestational age (HP:0001520)2.78713883
37Volvulus (HP:0002580)2.78413331
38Inability to walk (HP:0002540)2.76286851
39Tubular atrophy (HP:0000092)2.74750485
40Abolished electroretinogram (ERG) (HP:0000550)2.73675519
41Absent radius (HP:0003974)2.73252983
42Abnormality of the ileum (HP:0001549)2.71278730
43Patellar aplasia (HP:0006443)2.68481444
44Progressive inability to walk (HP:0002505)2.66042998
45Stenosis of the external auditory canal (HP:0000402)2.65936880
46Abnormal spermatogenesis (HP:0008669)2.64802893
47Abnormal drinking behavior (HP:0030082)2.60174488
48Polydipsia (HP:0001959)2.60174488
49Progressive cerebellar ataxia (HP:0002073)2.59293638
50Lip pit (HP:0100267)2.58217410
51Decreased circulating renin level (HP:0003351)2.58019211
52Aplasia involving forearm bones (HP:0009822)2.57412525
53Absent forearm bone (HP:0003953)2.57412525
54Premature ovarian failure (HP:0008209)2.57361221
55Genetic anticipation (HP:0003743)2.57163332
56Bronchitis (HP:0012387)2.57142856
57Gaze-evoked nystagmus (HP:0000640)2.57124212
58Meckel diverticulum (HP:0002245)2.57113525
59Absent/shortened dynein arms (HP:0200106)2.56752034
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.56752034
61Sclerocornea (HP:0000647)2.56250353
62Degeneration of anterior horn cells (HP:0002398)2.53837446
63Abnormality of the anterior horn cell (HP:0006802)2.53837446
64Severe visual impairment (HP:0001141)2.53780495
65Azoospermia (HP:0000027)2.52043382
66Aplasia/Hypoplasia of the patella (HP:0006498)2.49484787
67Type 2 muscle fiber atrophy (HP:0003554)2.46821291
68Congenital, generalized hypertrichosis (HP:0004540)2.46098503
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.43555214
70Furrowed tongue (HP:0000221)2.40353018
71Secondary amenorrhea (HP:0000869)2.39641332
72Protruding tongue (HP:0010808)2.36674534
73Abnormality of cochlea (HP:0000375)2.35207298
74True hermaphroditism (HP:0010459)2.34963105
75Bile duct proliferation (HP:0001408)2.34034277
76Abnormal biliary tract physiology (HP:0012439)2.34034277
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.30511936
78Clumsiness (HP:0002312)2.29737145
79Muscle fiber atrophy (HP:0100295)2.29068161
80Congenital hepatic fibrosis (HP:0002612)2.28435498
81Gait imbalance (HP:0002141)2.28296558
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26755613
83Pancreatic fibrosis (HP:0100732)2.23777052
84Anencephaly (HP:0002323)2.23395923
85Adrenal hypoplasia (HP:0000835)2.20771468
86Impulsivity (HP:0100710)2.20634085
87Congenital primary aphakia (HP:0007707)2.20154644
88Abnormal rod and cone electroretinograms (HP:0008323)2.19912801
89Nephroblastoma (Wilms tumor) (HP:0002667)2.18801583
90Renal cortical cysts (HP:0000803)2.18329729
91Aplastic anemia (HP:0001915)2.18272647
92Decreased central vision (HP:0007663)2.15290875
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.14360509
94Lissencephaly (HP:0001339)2.13531296
95Abnormality of the pons (HP:0007361)2.12727322
96Cerebellar dysplasia (HP:0007033)2.12154648
97Broad-based gait (HP:0002136)2.10979525
9811 pairs of ribs (HP:0000878)2.09649098
99Febrile seizures (HP:0002373)2.08967189
100Pendular nystagmus (HP:0012043)2.08659423
101Horseshoe kidney (HP:0000085)2.08364596
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.08231358
103Polyuria (HP:0000103)2.05673279
104Oral leukoplakia (HP:0002745)2.04610731
105Nephrogenic diabetes insipidus (HP:0009806)2.04308666
106Colon cancer (HP:0003003)2.03493942
107Hypoplasia of the pons (HP:0012110)2.02372553
108Short thumb (HP:0009778)2.02165573
109Concave nail (HP:0001598)2.01266965
110Abnormality of the labia minora (HP:0012880)2.01011412
111Keratoconus (HP:0000563)2.01002797
112Increased corneal curvature (HP:0100692)2.01002797
113Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00965448
114Embryonal renal neoplasm (HP:0011794)2.00929457
115Bilateral microphthalmos (HP:0007633)1.99381278
116Rhabdomyosarcoma (HP:0002859)1.98641967
117Absent hand (HP:0004050)1.98160102
118Pancreatic cysts (HP:0001737)1.97838661
119Fair hair (HP:0002286)1.97189932
120Renal salt wasting (HP:0000127)1.97110936
121Myelodysplasia (HP:0002863)1.96379578
122Overlapping toe (HP:0001845)1.96211797
123Severe muscular hypotonia (HP:0006829)1.94101696
124Male pseudohermaphroditism (HP:0000037)1.94057951
125Bone marrow hypocellularity (HP:0005528)1.92457295
126Genital tract atresia (HP:0001827)1.90737802
127Stomach cancer (HP:0012126)1.90490386
128Asplenia (HP:0001746)1.89827995
129Sparse eyelashes (HP:0000653)1.89540394
130Duodenal stenosis (HP:0100867)1.88807938
131Small intestinal stenosis (HP:0012848)1.88807938
132Chorioretinal atrophy (HP:0000533)1.87656244
133Hyperactive renin-angiotensin system (HP:0000841)1.87629214
134Hemiparesis (HP:0001269)1.87417059
135Hyperglycinuria (HP:0003108)1.87063536
136Vaginal atresia (HP:0000148)1.86867830
137Postaxial foot polydactyly (HP:0001830)1.86416093
138Hypoplasia of the radius (HP:0002984)1.85705235
139Bony spicule pigmentary retinopathy (HP:0007737)1.85420219
140Infertility (HP:0000789)1.85128131
141Sloping forehead (HP:0000340)1.85046889
142Woolly hair (HP:0002224)1.84700372
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82264158
144Triphalangeal thumb (HP:0001199)1.81739390
145Shawl scrotum (HP:0000049)1.81585060
146Facial cleft (HP:0002006)1.80547795
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80538793
148Pulmonary fibrosis (HP:0002206)1.79577787
149Optic nerve hypoplasia (HP:0000609)1.77910412
150Rough bone trabeculation (HP:0100670)1.77161369
151Hypoplastic labia majora (HP:0000059)1.76670557
152Spinal muscular atrophy (HP:0007269)1.76667864
153Methylmalonic acidemia (HP:0002912)1.76584419
154Abnormal umbilical cord blood vessels (HP:0011403)1.75963087
155Single umbilical artery (HP:0001195)1.75963087
156Abnormality of the fetal cardiovascular system (HP:0010948)1.75963087
157Abnormality of chloride homeostasis (HP:0011422)1.75246626
158Split foot (HP:0001839)1.74697481
159Abnormality of midbrain morphology (HP:0002418)1.74325473
160Molar tooth sign on MRI (HP:0002419)1.74325473
161Poor coordination (HP:0002370)1.72975872
162Optic nerve coloboma (HP:0000588)1.71708914
163Methylmalonic aciduria (HP:0012120)1.71623333
164Abnormality of cells of the erythroid lineage (HP:0012130)1.71562386
165Squamous cell carcinoma (HP:0002860)1.71441864
166Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70941853
167Tachypnea (HP:0002789)1.69835802
168Abnormality of macular pigmentation (HP:0008002)1.69431447
169Cleft eyelid (HP:0000625)1.68898962
170Absent speech (HP:0001344)1.67577114
171Sex reversal (HP:0012245)1.67454487
172Abnormal sex determination (HP:0012244)1.67454487
173Congenital sensorineural hearing impairment (HP:0008527)1.66633547
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66001540
175Preaxial hand polydactyly (HP:0001177)1.65869588
176Optic disc pallor (HP:0000543)1.65573707
177Intestinal atresia (HP:0011100)1.64986659
178Abnormality of renin-angiotensin system (HP:0000847)1.64695209
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.64165733
180Increased neuronal autofluorescent lipopigment (HP:0002074)1.64035053
181Generalized hypopigmentation of hair (HP:0011358)1.63651892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.44188339
2TTK3.42056737
3WEE13.40880358
4BUB13.25230253
5SRPK13.20090780
6PLK42.99712167
7CDC72.83803319
8WNK42.75526432
9BMPR22.65426625
10NEK22.57472617
11INSRR2.49222498
12ACVR1B2.39751834
13TLK12.36356834
14LMTK22.25503693
15PNCK2.12311807
16STK242.07191722
17EIF2AK12.06080118
18DYRK32.05146985
19RPS6KB22.03338439
20PINK12.02810006
21MAP4K22.02480237
22MAPKAPK31.95840621
23STK38L1.95452630
24CDK81.93859661
25MAP3K61.89812885
26EIF2AK31.87217235
27PLK11.83114523
28BRSK21.75358069
29DAPK21.70572051
30OXSR11.67206466
31MAPK131.64415639
32CASK1.59083713
33AURKB1.57468844
34EIF2AK21.54304930
35STK391.52252800
36CDK71.51963992
37CHEK21.51172095
38ZAK1.48209042
39VRK11.46348985
40TNIK1.45316160
41IRAK31.45009238
42MOS1.43290329
43STK161.42520093
44PLK31.40887096
45MAP3K41.37988901
46ADRBK11.36357843
47EPHA21.34929214
48PASK1.32291573
49BLK1.30763975
50MST41.30146689
51BRAF1.28127466
52ATR1.27118683
53MKNK11.26358620
54CDK31.25784985
55AURKA1.20663170
56NME11.18238858
57MELK1.18205898
58STK101.16781069
59MKNK21.15088141
60CAMKK21.14740862
61BMPR1B1.09423295
62ERBB31.09349967
63MAPK151.07890774
64LATS11.05622927
65TAOK31.05596119
66MAP3K31.03811592
67BRSK11.01857118
68FRK0.98858765
69NTRK30.98786473
70PRKCG0.97537995
71NLK0.97445032
72PAK30.95163732
73EEF2K0.94967755
74STK30.94932407
75CHEK10.92147008
76TSSK60.92095241
77ATM0.86183994
78PRKCE0.85809828
79PIK3CA0.85649119
80MAP3K80.82970377
81TRPM70.82866693
82NEK90.82679277
83RPS6KA40.80745726
84LATS20.78951314
85PTK2B0.78859667
86TGFBR10.77129514
87NME20.77022051
88IRAK10.72380046
89MARK10.71602977
90PHKG20.71119064
91PHKG10.71119064
92GRK10.70057019
93FGFR20.69123313
94PIM10.68852105
95TIE10.68552270
96DYRK20.67511249
97MAP2K70.67059569
98MUSK0.66968104
99NTRK20.64230268
100TRIM280.63169859
101CAMK1D0.62615204
102PRKCQ0.61621470
103MAPKAPK50.61103723
104PRKCI0.59577772
105MAP2K60.58879230
106TEC0.56678021
107CDK20.56110961
108CSNK1G20.55994843
109STK110.55220783
110PKN10.55059195
111ZAP700.54766444
112CAMK2A0.54529849
113CHUK0.53788264
114CSNK2A10.53162430
115PLK20.53099446
116CAMK10.53036277
117TNK20.50969468
118CDK40.48473282
119CDK90.47810356
120TESK10.47291956
121NEK10.46976623
122CAMK1G0.46894558
123NUAK10.46746140
124STK40.46551356
125EPHA40.46533380
126KIT0.46407537
127BCR0.45829030
128RPS6KA60.45589330
129LRRK20.45461683
130PRKACA0.45133302
131PDK40.44843047
132PDK30.44843047
133CSNK1G10.44165067
134MAP4K10.42934131
135CDK10.42490116
136TAF10.42298850
137PRKG20.41458368
138PRKAA20.41442292
139TXK0.40233666
140WNK30.39732600
141TAOK10.39572170
142IKBKB0.39131171
143ITK0.38899514
144WNK10.38755842
145AKT30.37050655
146CSNK1A1L0.35637926
147OBSCN0.35285474
148CSNK1A10.35133562
149CSNK2A20.34912730
150SIK20.34107701
151CSNK1G30.33952114
152PRKCA0.33766727
153ERBB20.33092456
154PRKAA10.33072766
155CDK120.32868302
156RPS6KA50.32815805
157SGK20.32261714
158MAP2K10.31540792
159CSNK1D0.30831058
160MAP2K20.28708806
161MAP3K20.28091988

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.20728765
2Mismatch repair_Homo sapiens_hsa034303.81231739
3Homologous recombination_Homo sapiens_hsa034403.66436328
4RNA polymerase_Homo sapiens_hsa030203.32627754
5Base excision repair_Homo sapiens_hsa034103.22341775
6Proteasome_Homo sapiens_hsa030503.11054668
7Cell cycle_Homo sapiens_hsa041103.06818735
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96916741
9Fanconi anemia pathway_Homo sapiens_hsa034602.86002877
10Ribosome_Homo sapiens_hsa030102.73585649
11Nitrogen metabolism_Homo sapiens_hsa009102.73535601
12Phototransduction_Homo sapiens_hsa047442.66458099
13RNA transport_Homo sapiens_hsa030132.66026961
14Basal transcription factors_Homo sapiens_hsa030222.58478314
15Nucleotide excision repair_Homo sapiens_hsa034202.56018070
16Pyrimidine metabolism_Homo sapiens_hsa002402.52110126
17Non-homologous end-joining_Homo sapiens_hsa034502.48184305
18Spliceosome_Homo sapiens_hsa030402.40629913
19Butanoate metabolism_Homo sapiens_hsa006502.34565761
20Nicotine addiction_Homo sapiens_hsa050332.28505195
21RNA degradation_Homo sapiens_hsa030182.26165589
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09741607
23Tryptophan metabolism_Homo sapiens_hsa003802.06235084
24p53 signaling pathway_Homo sapiens_hsa041152.04627147
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01975078
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95263910
27Oxidative phosphorylation_Homo sapiens_hsa001901.91123837
28Caffeine metabolism_Homo sapiens_hsa002321.80825499
29Protein export_Homo sapiens_hsa030601.77359964
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.54931949
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54027302
32Purine metabolism_Homo sapiens_hsa002301.54010295
33Taste transduction_Homo sapiens_hsa047421.45135287
34Morphine addiction_Homo sapiens_hsa050321.44924243
35mRNA surveillance pathway_Homo sapiens_hsa030151.44138182
36Linoleic acid metabolism_Homo sapiens_hsa005911.43768732
37Arachidonic acid metabolism_Homo sapiens_hsa005901.43354318
38ABC transporters_Homo sapiens_hsa020101.43009861
39Olfactory transduction_Homo sapiens_hsa047401.42617776
40Chemical carcinogenesis_Homo sapiens_hsa052041.37725794
41Parkinsons disease_Homo sapiens_hsa050121.34407366
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33683778
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32061435
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29908741
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28390832
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.25988588
47Propanoate metabolism_Homo sapiens_hsa006401.25030093
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22019044
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21791022
50Oocyte meiosis_Homo sapiens_hsa041141.18315586
51Circadian entrainment_Homo sapiens_hsa047131.16918349
52Histidine metabolism_Homo sapiens_hsa003401.16026134
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13463281
54One carbon pool by folate_Homo sapiens_hsa006701.12941765
55Peroxisome_Homo sapiens_hsa041461.10743440
56Epstein-Barr virus infection_Homo sapiens_hsa051691.10263122
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10258815
58Insulin secretion_Homo sapiens_hsa049111.10108187
59Cardiac muscle contraction_Homo sapiens_hsa042601.09434982
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.08742957
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08484034
62Retinol metabolism_Homo sapiens_hsa008301.08259546
63GABAergic synapse_Homo sapiens_hsa047271.07743360
64Serotonergic synapse_Homo sapiens_hsa047261.07363854
65Folate biosynthesis_Homo sapiens_hsa007901.07034591
66Glutamatergic synapse_Homo sapiens_hsa047241.04384646
67Regulation of autophagy_Homo sapiens_hsa041401.03645479
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02813592
69beta-Alanine metabolism_Homo sapiens_hsa004101.02718320
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.97019154
71Herpes simplex infection_Homo sapiens_hsa051680.96286316
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95902336
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94804155
74Alzheimers disease_Homo sapiens_hsa050100.89022615
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87982272
76Vitamin B6 metabolism_Homo sapiens_hsa007500.86886771
77HTLV-I infection_Homo sapiens_hsa051660.80153286
78Calcium signaling pathway_Homo sapiens_hsa040200.79367248
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78790145
80Salivary secretion_Homo sapiens_hsa049700.78493346
81Antigen processing and presentation_Homo sapiens_hsa046120.76782441
82Thyroid cancer_Homo sapiens_hsa052160.74541765
83Ovarian steroidogenesis_Homo sapiens_hsa049130.74314005
84Glycerolipid metabolism_Homo sapiens_hsa005610.73766588
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72792986
86Circadian rhythm_Homo sapiens_hsa047100.71604175
87Sulfur relay system_Homo sapiens_hsa041220.70017147
88Vitamin digestion and absorption_Homo sapiens_hsa049770.69070737
89Asthma_Homo sapiens_hsa053100.68187122
90Collecting duct acid secretion_Homo sapiens_hsa049660.67593726
91Hedgehog signaling pathway_Homo sapiens_hsa043400.66636020
92Fat digestion and absorption_Homo sapiens_hsa049750.66153978
93Mineral absorption_Homo sapiens_hsa049780.64915500
94Hippo signaling pathway_Homo sapiens_hsa043900.64795471
95Viral carcinogenesis_Homo sapiens_hsa052030.60500627
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59952434
97MicroRNAs in cancer_Homo sapiens_hsa052060.58359806
98Glutathione metabolism_Homo sapiens_hsa004800.56966886
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56146439
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55490666
101Huntingtons disease_Homo sapiens_hsa050160.55313440
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55143070
103Basal cell carcinoma_Homo sapiens_hsa052170.54842731
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.54032658
105Dopaminergic synapse_Homo sapiens_hsa047280.52941417
106Ether lipid metabolism_Homo sapiens_hsa005650.52778574
107Small cell lung cancer_Homo sapiens_hsa052220.52239415
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51816454
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48467482
110Sulfur metabolism_Homo sapiens_hsa009200.48086118
111Cocaine addiction_Homo sapiens_hsa050300.47611513
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46322076
113TGF-beta signaling pathway_Homo sapiens_hsa043500.45775322
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45119576
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.44526019
116Cholinergic synapse_Homo sapiens_hsa047250.44338125
117Gastric acid secretion_Homo sapiens_hsa049710.44111589
118Primary immunodeficiency_Homo sapiens_hsa053400.43637861
119Type I diabetes mellitus_Homo sapiens_hsa049400.42544204
120Long-term depression_Homo sapiens_hsa047300.41959550
121Dorso-ventral axis formation_Homo sapiens_hsa043200.41437965
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41295624
123cAMP signaling pathway_Homo sapiens_hsa040240.39824191
124Influenza A_Homo sapiens_hsa051640.39462009
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38349530
126Amphetamine addiction_Homo sapiens_hsa050310.38000267
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.37571114
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.37241977
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37214284
130FoxO signaling pathway_Homo sapiens_hsa040680.35931085
131Fatty acid biosynthesis_Homo sapiens_hsa000610.35698487
132Oxytocin signaling pathway_Homo sapiens_hsa049210.35226862
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.32702442
134Systemic lupus erythematosus_Homo sapiens_hsa053220.32544540
135Graft-versus-host disease_Homo sapiens_hsa053320.31794023
136Sphingolipid metabolism_Homo sapiens_hsa006000.30199374
137Tight junction_Homo sapiens_hsa045300.29652123
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29251689
139Prolactin signaling pathway_Homo sapiens_hsa049170.29007077
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28675457
141Pancreatic cancer_Homo sapiens_hsa052120.28592948
142Pathways in cancer_Homo sapiens_hsa052000.28325419
143Prostate cancer_Homo sapiens_hsa052150.27271535
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26480338
145Apoptosis_Homo sapiens_hsa042100.26239146
146Bladder cancer_Homo sapiens_hsa052190.25995814
147Pentose phosphate pathway_Homo sapiens_hsa000300.24658753
148Measles_Homo sapiens_hsa051620.24351666
149Adherens junction_Homo sapiens_hsa045200.23447768
150Wnt signaling pathway_Homo sapiens_hsa043100.22568118
151Legionellosis_Homo sapiens_hsa051340.22431365
152Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21901263
153Hepatitis B_Homo sapiens_hsa051610.20459148
154Intestinal immune network for IgA production_Homo sapiens_hsa046720.19763031
155Metabolic pathways_Homo sapiens_hsa011000.17851989
156Hepatitis C_Homo sapiens_hsa051600.15840891
157Acute myeloid leukemia_Homo sapiens_hsa052210.15400809
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.15180464
159Selenocompound metabolism_Homo sapiens_hsa004500.13138446
160RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13109579
161Colorectal cancer_Homo sapiens_hsa052100.12021576
162Fructose and mannose metabolism_Homo sapiens_hsa000510.11866838
163Autoimmune thyroid disease_Homo sapiens_hsa053200.10024847
164Hematopoietic cell lineage_Homo sapiens_hsa046400.09921070
165Cysteine and methionine metabolism_Homo sapiens_hsa002700.09775868

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