FAM221B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.01578622
2fusion of sperm to egg plasma membrane (GO:0007342)8.71342211
3multicellular organism reproduction (GO:0032504)7.96185209
4acrosome reaction (GO:0007340)7.60002703
5cell wall macromolecule metabolic process (GO:0044036)7.51255262
6cell wall macromolecule catabolic process (GO:0016998)7.51255262
7sperm-egg recognition (GO:0035036)7.35795815
8acrosome assembly (GO:0001675)7.02700018
9epithelial cilium movement (GO:0003351)6.72823651
10axonemal dynein complex assembly (GO:0070286)6.54422089
11reproduction (GO:0000003)6.50615989
12cell-cell recognition (GO:0009988)6.46088840
13binding of sperm to zona pellucida (GO:0007339)6.45749083
14plasma membrane fusion (GO:0045026)6.34848073
15spermatid development (GO:0007286)6.28669353
16regulation of cilium movement (GO:0003352)6.15380693
17cilium or flagellum-dependent cell motility (GO:0001539)5.99917008
18motile cilium assembly (GO:0044458)5.90233488
19single fertilization (GO:0007338)5.56746736
20behavioral response to nicotine (GO:0035095)5.45692081
21cilium movement (GO:0003341)5.34284611
22sperm capacitation (GO:0048240)5.17822839
23response to pheromone (GO:0019236)4.92511937
24microtubule depolymerization (GO:0007019)4.86379691
25piRNA metabolic process (GO:0034587)4.83565383
26GTP biosynthetic process (GO:0006183)4.50718929
27fertilization (GO:0009566)4.43131357
28male meiosis (GO:0007140)4.42100378
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.38843009
30sequestering of actin monomers (GO:0042989)4.25390559
31cellular ketone body metabolic process (GO:0046950)4.23579039
32fucose catabolic process (GO:0019317)4.21919410
33L-fucose metabolic process (GO:0042354)4.21919410
34L-fucose catabolic process (GO:0042355)4.21919410
35spermatogenesis (GO:0007283)4.12473353
36male gamete generation (GO:0048232)4.11431861
37synaptonemal complex organization (GO:0070193)4.00805647
38protein polyglutamylation (GO:0018095)3.99336372
39viral transcription (GO:0019083)3.92409886
40gamete generation (GO:0007276)3.80228824
41spermatid nucleus differentiation (GO:0007289)3.76271214
42translational termination (GO:0006415)3.76110066
43ketone body metabolic process (GO:1902224)3.75089863
44negative regulation of telomere maintenance (GO:0032205)3.74441015
45synaptonemal complex assembly (GO:0007130)3.73937202
46negative regulation of inclusion body assembly (GO:0090084)3.72424237
47male meiosis I (GO:0007141)3.70315294
48UTP biosynthetic process (GO:0006228)3.66228044
49protein neddylation (GO:0045116)3.59417866
50nephron epithelium morphogenesis (GO:0072088)3.58320936
51nephron tubule morphogenesis (GO:0072078)3.58320936
52nucleoside diphosphate phosphorylation (GO:0006165)3.54556827
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54104712
54ribosomal small subunit biogenesis (GO:0042274)3.52815090
55cotranslational protein targeting to membrane (GO:0006613)3.52418548
56tryptophan catabolic process (GO:0006569)3.50370000
57indole-containing compound catabolic process (GO:0042436)3.50370000
58indolalkylamine catabolic process (GO:0046218)3.50370000
59protein targeting to ER (GO:0045047)3.48985849
60ribosomal large subunit biogenesis (GO:0042273)3.47997144
61DNA methylation involved in gamete generation (GO:0043046)3.45761688
62indolalkylamine metabolic process (GO:0006586)3.42615119
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.40541833
64ventricular system development (GO:0021591)3.39929553
65ribosomal small subunit assembly (GO:0000028)3.38997750
66axoneme assembly (GO:0035082)3.38640847
67kynurenine metabolic process (GO:0070189)3.34627521
68neutrophil activation involved in immune response (GO:0002283)3.32053472
69protein localization to endoplasmic reticulum (GO:0070972)3.31076983
70protein complex biogenesis (GO:0070271)3.29605279
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.27880745
72germ cell development (GO:0007281)3.27054481
73cellular process involved in reproduction in multicellular organism (GO:0022412)3.25925717
74regulation of microtubule-based movement (GO:0060632)3.20782596
75negative regulation of mast cell activation (GO:0033004)3.17426481
76organic cation transport (GO:0015695)3.15369889
77cellular protein complex disassembly (GO:0043624)3.14772514
78guanosine-containing compound biosynthetic process (GO:1901070)3.13975437
79translational elongation (GO:0006414)3.11740100
80neuronal action potential (GO:0019228)3.10862342
81neural tube formation (GO:0001841)3.10807953
82single strand break repair (GO:0000012)3.10030213
83tryptophan metabolic process (GO:0006568)3.08026328
84mitochondrial respiratory chain complex I assembly (GO:0032981)3.07911439
85NADH dehydrogenase complex assembly (GO:0010257)3.07911439
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07911439
87mitochondrial respiratory chain complex assembly (GO:0033108)3.05444561
88regulation of inclusion body assembly (GO:0090083)3.05067404
89microtubule severing (GO:0051013)3.04743141
90chromosome organization involved in meiosis (GO:0070192)3.03716299
91centriole replication (GO:0007099)3.03421269
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02483589
93UTP metabolic process (GO:0046051)3.02344286
94detection of light stimulus involved in visual perception (GO:0050908)2.97744286
95detection of light stimulus involved in sensory perception (GO:0050962)2.97744286
96somite development (GO:0061053)2.97545444
97cornea development in camera-type eye (GO:0061303)2.96442776
98cilium morphogenesis (GO:0060271)2.95442932
99calcium ion-dependent exocytosis (GO:0017156)2.95278022
100retinal cone cell development (GO:0046549)2.94946724
101meiotic cell cycle (GO:0051321)2.93585727
102regulation of action potential (GO:0098900)2.93235763
103cell recognition (GO:0008037)2.91743237
104multicellular organismal reproductive process (GO:0048609)2.90650850
105platelet dense granule organization (GO:0060155)2.89395061
106viral life cycle (GO:0019058)2.89083620
107CTP biosynthetic process (GO:0006241)2.89079509
108CTP metabolic process (GO:0046036)2.89079509
109maturation of SSU-rRNA (GO:0030490)2.88471411
110DNA deamination (GO:0045006)2.88469297
111water-soluble vitamin biosynthetic process (GO:0042364)2.88319949
112meiosis I (GO:0007127)2.88190545
113rhodopsin mediated signaling pathway (GO:0016056)2.87339710
114protein-cofactor linkage (GO:0018065)2.86089883
115nonmotile primary cilium assembly (GO:0035058)2.85674224
116proteasome assembly (GO:0043248)2.81689974
117regulation of rhodopsin mediated signaling pathway (GO:0022400)2.80870719
118microtubule polymerization or depolymerization (GO:0031109)2.77963376
119regulation of glucokinase activity (GO:0033131)2.77613862
120regulation of hexokinase activity (GO:1903299)2.77613862
121preassembly of GPI anchor in ER membrane (GO:0016254)2.76969317
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76432458
123respiratory chain complex IV assembly (GO:0008535)2.74802654
124meiotic nuclear division (GO:0007126)2.74331158
125cilium organization (GO:0044782)2.74024455
126left/right pattern formation (GO:0060972)2.72969615
127cellular response to ATP (GO:0071318)2.72375496
128pyrimidine nucleobase catabolic process (GO:0006208)2.71188740
129mannosylation (GO:0097502)2.70673114
130ATP synthesis coupled proton transport (GO:0015986)2.69880215
131energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69880215
132protein localization to cilium (GO:0061512)2.68300458
133protein complex disassembly (GO:0043241)2.67567551
134photoreceptor cell development (GO:0042461)2.67503441
135alanine transport (GO:0032328)2.66509232
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65989083
137positive regulation of monocyte chemotaxis (GO:0090026)2.65670482
138cilium assembly (GO:0042384)2.64710338
139response to peptidoglycan (GO:0032494)2.63876181
140intraciliary transport (GO:0042073)2.63588569
141ubiquinone biosynthetic process (GO:0006744)2.63458094
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62143951
143respiratory burst (GO:0045730)2.61896104
144regulation of protein kinase C signaling (GO:0090036)2.61525667
145translational initiation (GO:0006413)2.60269004
146termination of RNA polymerase III transcription (GO:0006386)2.60126112
147transcription elongation from RNA polymerase III promoter (GO:0006385)2.60126112
148synaptic transmission, cholinergic (GO:0007271)2.60069668
149chromosome condensation (GO:0030261)2.59053378
150indole-containing compound metabolic process (GO:0042430)2.59044693
151natural killer cell mediated cytotoxicity (GO:0042267)2.58317217
152natural killer cell mediated immunity (GO:0002228)2.58317217
153membrane depolarization during action potential (GO:0086010)2.58272906
154spinal cord motor neuron differentiation (GO:0021522)2.57309394
155positive regulation of protein kinase C signaling (GO:0090037)2.56703031
156macromolecular complex disassembly (GO:0032984)2.56630969
157exogenous drug catabolic process (GO:0042738)2.56280011
158cytochrome complex assembly (GO:0017004)2.56149879
159renal tubule morphogenesis (GO:0061333)2.55232515
160reflex (GO:0060004)2.55080514
161translation (GO:0006412)2.54752067
162glycerol ether metabolic process (GO:0006662)2.54647325
163regulation of telomere maintenance (GO:0032204)2.53794778
164gamma-aminobutyric acid transport (GO:0015812)2.52960543
165kidney morphogenesis (GO:0060993)2.52563472
166neuron fate determination (GO:0048664)2.51847936
167establishment of protein localization to Golgi (GO:0072600)2.49980792
168regulation of spindle checkpoint (GO:0090231)2.49843793
169amine catabolic process (GO:0009310)2.49586205
170cellular biogenic amine catabolic process (GO:0042402)2.49586205
171reciprocal meiotic recombination (GO:0007131)2.49584935
172reciprocal DNA recombination (GO:0035825)2.49584935
173pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.49025398
174multicellular organismal development (GO:0007275)2.48286949
175glycerophospholipid catabolic process (GO:0046475)2.47780891
176protein localization to Golgi apparatus (GO:0034067)2.46980892
177DNA packaging (GO:0006323)2.46671961
178somite rostral/caudal axis specification (GO:0032525)2.45651182
179neuron fate specification (GO:0048665)2.45429444
180regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.43436154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.08988831
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.42221464
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.32484505
4ZNF274_21170338_ChIP-Seq_K562_Hela3.98366415
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.96229990
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.71900555
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.26855599
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.86451190
9VDR_22108803_ChIP-Seq_LS180_Human2.61877415
10EZH2_22144423_ChIP-Seq_EOC_Human2.54146652
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49894055
12GBX2_23144817_ChIP-Seq_PC3_Human2.46784964
13IGF1R_20145208_ChIP-Seq_DFB_Human2.38787064
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.34569623
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30659406
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30432129
17FUS_26573619_Chip-Seq_HEK293_Human2.29485837
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26910141
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20977930
20TAF15_26573619_Chip-Seq_HEK293_Human2.20127291
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.18215532
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16988251
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.15617288
24P300_19829295_ChIP-Seq_ESCs_Human1.96994341
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96079698
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86544544
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84527347
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84110619
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.84095834
30ER_23166858_ChIP-Seq_MCF-7_Human1.81112986
31EWS_26573619_Chip-Seq_HEK293_Human1.79082442
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78049622
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77343194
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76229318
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74390428
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69891725
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68547964
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68350025
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66042313
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64689441
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.61425071
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61310765
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61310765
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59264077
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57696291
46CBP_20019798_ChIP-Seq_JUKART_Human1.57696291
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.57080788
48TP53_22573176_ChIP-Seq_HFKS_Human1.56405558
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.50994606
50AR_25329375_ChIP-Seq_VCAP_Human1.50753662
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50556117
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49114645
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48326143
54REST_21632747_ChIP-Seq_MESCs_Mouse1.45703600
55BCAT_22108803_ChIP-Seq_LS180_Human1.44449996
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41870372
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41153515
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40403301
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.39685151
60IRF1_19129219_ChIP-ChIP_H3396_Human1.38816157
61NANOG_19829295_ChIP-Seq_ESCs_Human1.38195526
62SOX2_19829295_ChIP-Seq_ESCs_Human1.38195526
63AR_21572438_ChIP-Seq_LNCaP_Human1.37513817
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37136175
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36879298
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.36872806
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36805218
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.36805218
69SMAD4_21799915_ChIP-Seq_A2780_Human1.36634790
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35455344
71STAT3_23295773_ChIP-Seq_U87_Human1.34978766
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33085286
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32779212
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.31299206
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.29408045
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29309202
77MYC_18940864_ChIP-ChIP_HL60_Human1.28801686
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.28069969
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26837466
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.26711467
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.26631795
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.26222891
83STAT1_17558387_ChIP-Seq_HELA_Human1.25783543
84TCF4_22108803_ChIP-Seq_LS180_Human1.24599195
85TCF4_23295773_ChIP-Seq_U87_Human1.24518225
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23341654
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23122891
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22821726
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21600336
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21242084
91DCP1A_22483619_ChIP-Seq_HELA_Human1.18591514
92GATA3_21867929_ChIP-Seq_CD8_Mouse1.17855051
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17623824
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.17559775
95AR_20517297_ChIP-Seq_VCAP_Human1.17405599
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16862488
97VDR_23849224_ChIP-Seq_CD4+_Human1.16433619
98GATA3_21867929_ChIP-Seq_TH1_Mouse1.15945920
99RUNX2_22187159_ChIP-Seq_PCA_Human1.15795912
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14865803
101P53_22387025_ChIP-Seq_ESCs_Mouse1.13957163
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13639062
103NCOR_22424771_ChIP-Seq_293T_Human1.12952637
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12867682
105SOX2_22085726_ChIP-Seq_NPCs_Mouse1.12549846
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12219598
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.11914073
108P300_18555785_Chip-Seq_ESCs_Mouse1.11577506
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.10887551
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10871746
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10687161
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.10513649
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.10368270
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.10184502
115HOXB7_26014856_ChIP-Seq_BT474_Human1.10034016
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09951021
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09619881
118ERA_21632823_ChIP-Seq_H3396_Human1.09552676
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09166593
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08404064
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.08143812
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07669371
123NMYC_18555785_Chip-Seq_ESCs_Mouse1.06847765
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.06489643
125MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06304129
126STAT1_20625510_ChIP-Seq_HELA_Human1.06252639
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06168182
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.05900038
129MYC_19829295_ChIP-Seq_ESCs_Human1.05197719
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.05146493
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04676121
132YY1_21170310_ChIP-Seq_MESCs_Mouse1.04412497
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04056110
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03921703
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.03425877
136JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02883913
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01861558
138FOXH1_21741376_ChIP-Seq_EPCs_Human1.01513818
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01477588
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.01229782
141AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01226414
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00275588
143SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00213334
144RNF2_27304074_Chip-Seq_NSC_Mouse1.00153024
145REST_18959480_ChIP-ChIP_MESCs_Mouse0.99345055
146SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98942257
147JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98686918
148ZFX_18555785_Chip-Seq_ESCs_Mouse0.98393209
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97810949
150NANOG_20526341_ChIP-Seq_ESCs_Human0.97057593
151GATA1_26923725_Chip-Seq_HPCs_Mouse0.97004550
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96925183
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96370350
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.95891511
155RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95817588
156TP63_19390658_ChIP-ChIP_HaCaT_Human0.95812307
157SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95642098
158PU1_27457419_Chip-Seq_LIVER_Mouse0.95615199
159SOX2_18555785_Chip-Seq_ESCs_Mouse0.95353848
160ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95158446
161KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95005964
162ETV1_20927104_ChIP-Seq_GIST48_Human0.94953772
163RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94882755
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93978859
165SRF_21415370_ChIP-Seq_HL-1_Mouse0.93788488
166SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93344401
167SPI1_23547873_ChIP-Seq_NB4_Human0.92923148
168HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90650620
169SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89154894
170E2F1_18555785_Chip-Seq_ESCs_Mouse0.89044138
171PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88533269
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88103382
173RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87278447
174TTF2_22483619_ChIP-Seq_HELA_Human0.86587415
175ELK1_19687146_ChIP-ChIP_HELA_Human0.86544845
176CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84799046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive3.54751270
2MP0001929_abnormal_gametogenesis3.35198912
3MP0003136_yellow_coat_color3.00625747
4MP0009379_abnormal_foot_pigmentation2.97913475
5MP0001835_abnormal_antigen_presentation2.84078916
6MP0002148_abnormal_hypersensitivity_rea2.79441303
7MP0000569_abnormal_digit_pigmentation2.60368347
8MP0009785_altered_susceptibility_to2.48864651
9MP0002163_abnormal_gland_morphology2.39988367
10MP0005551_abnormal_eye_electrophysiolog2.35967793
11MP0003724_increased_susceptibility_to2.35559293
12MP0002210_abnormal_sex_determination2.34243515
13MP0008877_abnormal_DNA_methylation2.21301935
14MP0008875_abnormal_xenobiotic_pharmacok2.15578453
15MP0006082_CNS_inflammation2.15525471
16MP0001485_abnormal_pinna_reflex2.13377458
17MP0002837_dystrophic_cardiac_calcinosis2.07695307
18MP0004381_abnormal_hair_follicle2.02749958
19MP0005410_abnormal_fertilization10.0280312
20MP0005377_hearing/vestibular/ear_phenot1.94336858
21MP0003878_abnormal_ear_physiology1.94336858
22MP0006072_abnormal_retinal_apoptosis1.92719822
23MP0005671_abnormal_response_to1.90018851
24MP0005000_abnormal_immune_tolerance1.88823050
25MP0002161_abnormal_fertility/fecundity1.85915095
26MP0003787_abnormal_imprinting1.83124791
27MP0004133_heterotaxia1.80829167
28MP0009745_abnormal_behavioral_response1.80816325
29MP0003195_calcinosis1.78933567
30MP0005646_abnormal_pituitary_gland1.78631428
31MP0001145_abnormal_male_reproductive1.77907401
32MP0005025_abnormal_response_to1.72418416
33MP0002272_abnormal_nervous_system1.70211062
34MP0005645_abnormal_hypothalamus_physiol1.66881882
35MP0009046_muscle_twitch1.65569951
36MP0003436_decreased_susceptibility_to1.64813482
37MP0003011_delayed_dark_adaptation1.63535912
38MP0002277_abnormal_respiratory_mucosa1.63320894
39MP0006276_abnormal_autonomic_nervous1.62999010
40MP0002234_abnormal_pharynx_morphology1.62737760
41MP0008872_abnormal_physiological_respon1.62102749
42MP0004885_abnormal_endolymph1.60298144
43MP0002876_abnormal_thyroid_physiology1.58372530
44MP0002419_abnormal_innate_immunity1.58106296
45MP0000653_abnormal_sex_gland1.56306038
46MP0002102_abnormal_ear_morphology1.52742157
47MP0002928_abnormal_bile_duct1.47380063
48MP0001984_abnormal_olfaction1.46213376
49MP0002723_abnormal_immune_serum1.45888506
50MP0002557_abnormal_social/conspecific_i1.43129506
51MP0004043_abnormal_pH_regulation1.42826720
52MP0001486_abnormal_startle_reflex1.39327701
53MP0001188_hyperpigmentation1.38741547
54MP0002452_abnormal_antigen_presenting1.37903861
55MP0002572_abnormal_emotion/affect_behav1.37813972
56MP0005379_endocrine/exocrine_gland_phen1.35374046
57MP0000685_abnormal_immune_system1.34906050
58MP0001501_abnormal_sleep_pattern1.34843177
59MP0005409_darkened_coat_color1.34785579
60MP0000631_abnormal_neuroendocrine_gland1.33699635
61MP0002405_respiratory_system_inflammati1.33647634
62MP0001790_abnormal_immune_system1.33556883
63MP0005387_immune_system_phenotype1.33556883
64MP0002132_abnormal_respiratory_system1.33514893
65MP0008260_abnormal_autophagy1.32294674
66MP0009333_abnormal_splenocyte_physiolog1.30138941
67MP0005174_abnormal_tail_pigmentation1.27464957
68MP0001819_abnormal_immune_cell1.27336248
69MP0003122_maternal_imprinting1.25412339
70MP0002420_abnormal_adaptive_immunity1.24562701
71MP0002064_seizures1.24393587
72MP0003646_muscle_fatigue1.24052016
73MP0002735_abnormal_chemical_nociception1.23725585
74MP0000427_abnormal_hair_cycle1.23090553
75MP0001800_abnormal_humoral_immune1.21306115
76MP0002638_abnormal_pupillary_reflex1.20019441
77MP0002067_abnormal_sensory_capabilities1.19662880
78MP0003186_abnormal_redox_activity1.18276061
79MP0005451_abnormal_body_composition1.17469729
80MP0000372_irregular_coat_pigmentation1.17359689
81MP0002733_abnormal_thermal_nociception1.16903022
82MP0000015_abnormal_ear_pigmentation1.15405839
83MP0001970_abnormal_pain_threshold1.12965429
84MP0004215_abnormal_myocardial_fiber1.12789425
85MP0001986_abnormal_taste_sensitivity1.12535323
86MP0005167_abnormal_blood-brain_barrier1.10723498
87MP0002653_abnormal_ependyma_morphology1.09147460
88MP0008789_abnormal_olfactory_epithelium1.09108129
89MP0008058_abnormal_DNA_repair1.08207681
90MP0005423_abnormal_somatic_nervous1.07577607
91MP0001905_abnormal_dopamine_level1.07500794
92MP0000566_synostosis1.07419560
93MP0002282_abnormal_trachea_morphology1.06752988
94MP0003121_genomic_imprinting1.05339212
95MP0002160_abnormal_reproductive_system1.04974381
96MP0002063_abnormal_learning/memory/cond1.04900619
97MP0003252_abnormal_bile_duct1.04342191
98MP0005195_abnormal_posterior_eye1.01954432
99MP0010386_abnormal_urinary_bladder1.01470944
100MP0000920_abnormal_myelination1.01183141
101MP0003635_abnormal_synaptic_transmissio0.99810418
102MP0001963_abnormal_hearing_physiology0.99585797
103MP0000778_abnormal_nervous_system0.97939283
104MP0004742_abnormal_vestibular_system0.97160784
105MP0005171_absent_coat_pigmentation0.97089055
106MP0003718_maternal_effect0.96831964
107MP0003950_abnormal_plasma_membrane0.95821752
108MP0001293_anophthalmia0.95130595
109MP0002184_abnormal_innervation0.92398904
110MP0005310_abnormal_salivary_gland0.91803430
111MP0004145_abnormal_muscle_electrophysio0.91343651
112MP0002752_abnormal_somatic_nervous0.90350335
113MP0002229_neurodegeneration0.90032529
114MP0005386_behavior/neurological_phenoty0.88608027
115MP0004924_abnormal_behavior0.88608027
116MP0003786_premature_aging0.87835888
117MP0000647_abnormal_sebaceous_gland0.87017819
118MP0008932_abnormal_embryonic_tissue0.86282689
119MP0008775_abnormal_heart_ventricle0.86030658
120MP0003315_abnormal_perineum_morphology0.85781448
121MP0003890_abnormal_embryonic-extraembry0.85741758
122MP0002734_abnormal_mechanical_nocicepti0.85600603
123MP0005499_abnormal_olfactory_system0.85110491
124MP0005394_taste/olfaction_phenotype0.85110491
125MP0004147_increased_porphyrin_level0.84777527
126MP0008057_abnormal_DNA_replication0.84473169
127MP0001348_abnormal_lacrimal_gland0.83696061
128MP0001346_abnormal_lacrimal_gland0.83194729
129MP0000716_abnormal_immune_system0.82216022
130MP0000858_altered_metastatic_potential0.79418485
131MP0005084_abnormal_gallbladder_morpholo0.78471932
132MP0008995_early_reproductive_senescence0.77637611
133MP0002138_abnormal_hepatobiliary_system0.76223299
134MP0002736_abnormal_nociception_after0.76133288
135MP0001845_abnormal_inflammatory_respons0.75991832
136MP0003448_altered_tumor_morphology0.75137068
137MP0002398_abnormal_bone_marrow0.74963021
138MP0002938_white_spotting0.74439801
139MP0005408_hypopigmentation0.74299521
140MP0002006_tumorigenesis0.72826709
141MP0002009_preneoplasia0.72546331
142MP0005075_abnormal_melanosome_morpholog0.71987914
143MP0003763_abnormal_thymus_physiology0.71141577
144MP0000049_abnormal_middle_ear0.68281624
145MP0006292_abnormal_olfactory_placode0.67496133
146MP0005389_reproductive_system_phenotype0.66530254
147MP0001529_abnormal_vocalization0.65030803
148MP0003880_abnormal_central_pattern0.64977879
149MP0004142_abnormal_muscle_tone0.64564766
150MP0002429_abnormal_blood_cell0.64334863
151MP0010094_abnormal_chromosome_stability0.64074183
152MP0008469_abnormal_protein_level0.63894500
153MP0009764_decreased_sensitivity_to0.63300115
154MP0002177_abnormal_outer_ear0.62967019
155MP0001533_abnormal_skeleton_physiology0.61927347
156MP0005253_abnormal_eye_physiology0.61603024
157MP0001119_abnormal_female_reproductive0.61006541
158MP0009250_abnormal_appendicular_skeleto0.60330064
159MP0001968_abnormal_touch/_nociception0.59932690
160MP0001853_heart_inflammation0.58220223
161MP0002095_abnormal_skin_pigmentation0.55449376
162MP0000026_abnormal_inner_ear0.55391448

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.82556375
2Absent/shortened dynein arms (HP:0200106)8.82556375
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.42545352
4Abnormal respiratory motile cilium morphology (HP:0005938)6.35615452
5Abnormal respiratory epithelium morphology (HP:0012253)6.35615452
6Abnormal respiratory motile cilium physiology (HP:0012261)6.06914066
7Abnormal ciliary motility (HP:0012262)5.11739093
8Rhinitis (HP:0012384)4.76505240
9Congenital stationary night blindness (HP:0007642)4.49613310
10Pancreatic cysts (HP:0001737)4.48454706
11Pancreatic fibrosis (HP:0100732)4.26417906
12Infertility (HP:0000789)4.06231155
13Chronic bronchitis (HP:0004469)3.82005253
14Nephronophthisis (HP:0000090)3.62939266
15Nasal polyposis (HP:0100582)3.61843948
16Chronic hepatic failure (HP:0100626)3.60846851
17Increased hepatocellular lipid droplets (HP:0006565)3.47591085
18Acute necrotizing encephalopathy (HP:0006965)3.22066136
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18813594
20Abnormal drinking behavior (HP:0030082)3.16265008
21Polydipsia (HP:0001959)3.16265008
22Abolished electroretinogram (ERG) (HP:0000550)3.10785495
23Exertional dyspnea (HP:0002875)3.10645620
24Recurrent abscess formation (HP:0002722)3.10226305
25Mitochondrial inheritance (HP:0001427)3.10067168
26Abnormal rod and cone electroretinograms (HP:0008323)3.08606588
27Renal Fanconi syndrome (HP:0001994)3.07788737
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.99760866
293-Methylglutaconic aciduria (HP:0003535)2.96289072
30Bony spicule pigmentary retinopathy (HP:0007737)2.96168223
31Pendular nystagmus (HP:0012043)2.95569056
32Bronchiectasis (HP:0002110)2.93898160
33Abnormality of the renal cortex (HP:0011035)2.93261630
34Lipid accumulation in hepatocytes (HP:0006561)2.88507553
35Bronchitis (HP:0012387)2.87686613
36Abnormality of the nasal mucosa (HP:0000433)2.87300645
37Tubular atrophy (HP:0000092)2.87200358
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86983256
39Type II lissencephaly (HP:0007260)2.82603025
40Sclerocornea (HP:0000647)2.80129312
41Cystic liver disease (HP:0006706)2.77825000
42Abnormality of cells of the erythroid lineage (HP:0012130)2.75248302
43Abnormality of renal resorption (HP:0011038)2.73150780
44Abnormal mitochondria in muscle tissue (HP:0008316)2.73089103
45Abnormal spermatogenesis (HP:0008669)2.71711461
46Recurrent bacterial skin infections (HP:0005406)2.69294305
47Male infertility (HP:0003251)2.65719715
48Progressive macrocephaly (HP:0004481)2.65191392
49Abnormality of the renal medulla (HP:0100957)2.64837250
50Abnormality of alanine metabolism (HP:0010916)2.64654290
51Hyperalaninemia (HP:0003348)2.64654290
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64654290
53Recurrent sinusitis (HP:0011108)2.62334474
54Reticulocytopenia (HP:0001896)2.61383431
55Parakeratosis (HP:0001036)2.60292978
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58376505
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57979361
58Medial flaring of the eyebrow (HP:0010747)2.56388277
59Optic neuritis (HP:0100653)2.55142161
60Retrobulbar optic neuritis (HP:0100654)2.55142161
61Optic disc pallor (HP:0000543)2.53866419
62Progressive cerebellar ataxia (HP:0002073)2.49991514
63Abnormal number of erythroid precursors (HP:0012131)2.49641647
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49122355
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49122355
66Inability to walk (HP:0002540)2.47720892
67Hyperventilation (HP:0002883)2.46089207
68Gait imbalance (HP:0002141)2.37728500
69Polyuria (HP:0000103)2.36828297
70Increased CSF lactate (HP:0002490)2.34817949
71Increased corneal curvature (HP:0100692)2.32154981
72Keratoconus (HP:0000563)2.32154981
73Dyschromatopsia (HP:0007641)2.28330517
74Acute encephalopathy (HP:0006846)2.27667547
75Anencephaly (HP:0002323)2.27467291
76Lissencephaly (HP:0001339)2.27319274
77Genetic anticipation (HP:0003743)2.26559019
78Congenital, generalized hypertrichosis (HP:0004540)2.25352234
79Chronic obstructive pulmonary disease (HP:0006510)2.25293061
80Obstructive lung disease (HP:0006536)2.25293061
81Recurrent bronchitis (HP:0002837)2.24807520
82Hypothermia (HP:0002045)2.24410330
83Macrocytic anemia (HP:0001972)2.23671609
84Congenital primary aphakia (HP:0007707)2.21630411
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.19678208
86Poor head control (HP:0002421)2.18493322
87Stomatitis (HP:0010280)2.17038532
88Bile duct proliferation (HP:0001408)2.17017355
89Abnormal biliary tract physiology (HP:0012439)2.17017355
90Cleft eyelid (HP:0000625)2.15954416
91Large for gestational age (HP:0001520)2.15649616
92Nephrogenic diabetes insipidus (HP:0009806)2.15095389
93Congenital hepatic fibrosis (HP:0002612)2.14753267
94Hepatocellular necrosis (HP:0001404)2.13317615
95Sensory axonal neuropathy (HP:0003390)2.13308549
96Progressive inability to walk (HP:0002505)2.11855680
97Male pseudohermaphroditism (HP:0000037)2.11371301
98Pallor (HP:0000980)2.11294486
99Furrowed tongue (HP:0000221)2.07879109
100Eczematoid dermatitis (HP:0000976)2.07546470
101Increased IgM level (HP:0003496)2.05240905
102Increased intramyocellular lipid droplets (HP:0012240)2.03512474
103Orchitis (HP:0100796)2.03471974
104Gaze-evoked nystagmus (HP:0000640)2.03132416
105Oligodactyly (hands) (HP:0001180)2.01186157
106Abnormal urine output (HP:0012590)1.99348859
107Abnormality of macular pigmentation (HP:0008002)1.98133863
108Cerebellar dysplasia (HP:0007033)1.96779971
109Mediastinal lymphadenopathy (HP:0100721)1.96749342
110Concave nail (HP:0001598)1.96614152
111Hyperglycinuria (HP:0003108)1.94864615
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94457122
113Optic nerve hypoplasia (HP:0000609)1.94300540
114Limb dystonia (HP:0002451)1.93668786
115Recurrent otitis media (HP:0000403)1.91899527
116Molar tooth sign on MRI (HP:0002419)1.88583109
117Abnormality of midbrain morphology (HP:0002418)1.88583109
118Genital tract atresia (HP:0001827)1.88462696
119Abnormal hemoglobin (HP:0011902)1.88067718
120Respiratory difficulties (HP:0002880)1.87970007
121Exercise intolerance (HP:0003546)1.86418022
122Impulsivity (HP:0100710)1.85135402
123Recurrent gram-negative bacterial infections (HP:0005420)1.84106436
124Microvesicular hepatic steatosis (HP:0001414)1.83985705
125Abnormality of the pons (HP:0007361)1.82735627
126Decreased circulating renin level (HP:0003351)1.82226273
127Myositis (HP:0100614)1.82116004
128Congenital ichthyosiform erythroderma (HP:0007431)1.82075530
129Patellar aplasia (HP:0006443)1.81999574
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81091215
131Vaginal atresia (HP:0000148)1.80554643
132Preaxial hand polydactyly (HP:0001177)1.79929601
133Febrile seizures (HP:0002373)1.78860192
134Severe visual impairment (HP:0001141)1.78683061
135Amniotic constriction ring (HP:0009775)1.78026958
136Abnormality of placental membranes (HP:0011409)1.78026958
137Aplasia/Hypoplasia of the patella (HP:0006498)1.77457757
138Leukodystrophy (HP:0002415)1.77439691
139Abnormality of renal excretion (HP:0011036)1.75844232
140Azoospermia (HP:0000027)1.74973177
141Tubulointerstitial nephritis (HP:0001970)1.73304273
142Renal cortical cysts (HP:0000803)1.72800338
143Triphalangeal thumb (HP:0001199)1.71942861
144Occipital encephalocele (HP:0002085)1.70934042
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70596328
146Elevated erythrocyte sedimentation rate (HP:0003565)1.70162176
147Methylmalonic acidemia (HP:0002912)1.70127653
148Postaxial hand polydactyly (HP:0001162)1.69583770
149Broad-based gait (HP:0002136)1.69459406
150Recurrent skin infections (HP:0001581)1.67868571
151Chorioretinal atrophy (HP:0000533)1.66879802
152Septo-optic dysplasia (HP:0100842)1.66180339
153Hypoplasia of the pons (HP:0012110)1.65833050
154Stage 5 chronic kidney disease (HP:0003774)1.65727659
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.65321612
156Polyphagia (HP:0002591)1.65119112
157Type I transferrin isoform profile (HP:0003642)1.65071050
158Autoimmune hemolytic anemia (HP:0001890)1.64284887
159Postaxial foot polydactyly (HP:0001830)1.62168163
160Hyperphosphaturia (HP:0003109)1.59969115
161Increased muscle lipid content (HP:0009058)1.58922955
162Decreased central vision (HP:0007663)1.58478501
163Respiratory failure (HP:0002878)1.58099953
164Hepatic necrosis (HP:0002605)1.57921795
165Increased serum lactate (HP:0002151)1.57733305
166True hermaphroditism (HP:0010459)1.57437726
167Hepatosplenomegaly (HP:0001433)1.56443841
168Recurrent pneumonia (HP:0006532)1.51271465
169Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.49970032
170Abnormality of the phalanges of the hallux (HP:0010057)1.49807211
171Attenuation of retinal blood vessels (HP:0007843)1.49637614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.14557272
2TESK14.47064630
3FRK4.32025648
4PDK33.55640717
5PDK43.55640717
6MAP4K23.22220330
7WNK33.08515051
8PBK3.00322168
9PDK22.89538562
10PRKD32.49549335
11NME22.46888679
12STK392.44977025
13EIF2AK12.37728196
14CASK2.06903570
15INSRR2.05814286
16BLK1.98492739
17MAPK131.84841974
18MAP3K41.83147867
19TESK21.78831284
20IRAK41.76927013
21TXK1.75313934
22PIM21.72065105
23ACVR1B1.65954105
24BMPR21.61642464
25WNK41.59863549
26MAP3K141.58381726
27RIPK41.55830188
28TAOK31.54164727
29MARK11.52000469
30IRAK31.46084899
31PNCK1.43283710
32BMPR1B1.38674498
33PLK21.37046461
34SRPK11.36571246
35BRAF1.30240617
36BUB11.29897080
37NEK91.28786471
38MKNK21.27984139
39PTK2B1.27820982
40DAPK21.18797492
41ICK1.18654037
42PHKG11.17486910
43PHKG21.17486910
44ADRBK11.15265347
45IRAK11.15115399
46TIE11.14453153
47CAMKK21.13834636
48TGFBR11.11139183
49STK161.06838636
50NME11.05710167
51ARAF1.04359959
52PAK31.04286200
53CLK11.02807901
54MST41.02433541
55IKBKB1.00500484
56PRKCG0.98942153
57DYRK1B0.93365639
58MUSK0.92176046
59EIF2AK30.92035072
60IRAK20.91939716
61NTRK20.88986612
62VRK10.87645171
63MST1R0.83531854
64PRKCE0.81051944
65YES10.80237270
66TRIM280.80172475
67DYRK30.79918104
68TBK10.79329273
69IKBKE0.78053858
70DAPK30.78034854
71BCKDK0.76927157
72PRPF4B0.76694980
73MAP2K70.76584954
74NTRK30.76433394
75EPHB20.75909186
76PLK40.75883789
77DYRK20.75740563
78PIK3CA0.75436555
79ADRBK20.75353925
80TAF10.74736814
81TEC0.72782555
82MAP4K10.71170316
83STK380.69956546
84ZAP700.69685063
85PIM10.69434944
86CSNK1G20.69279394
87ABL20.66830408
88EPHA40.65096602
89STK38L0.64723310
90CDK190.63059423
91PRKCI0.62902354
92SIK20.62374092
93CAMK2A0.61876063
94STK110.61642844
95PKN10.60588238
96BCR0.59987558
97CSNK1G10.58830207
98MYLK0.58684241
99MKNK10.58525879
100GRK70.57585086
101EIF2AK20.56727861
102LIMK10.55702257
103NEK60.55439951
104PINK10.55182377
105PRKACA0.54326373
106TNK20.53346678
107BRSK20.53253259
108CAMK10.52848150
109CSNK1G30.52588906
110LYN0.51955153
111OBSCN0.51882000
112CDK80.51423816
113TSSK60.51238195
114PAK10.51183390
115PLK30.51168621
116CSNK2A10.50352291
117MAP2K60.50125642
118PRKCZ0.49939369
119MAP3K120.49547134
120WNK10.49286277
121OXSR10.48837667
122CSNK1A10.47876794
123CSK0.47555734
124PRKCQ0.47021635
125MAPKAPK50.46860103
126MAPK150.46491625
127RPS6KA50.45930083
128NEK20.45645196
129PRKCD0.45566270
130AURKA0.44208580
131CCNB10.43906945
132WEE10.43575687
133MAPKAPK30.42989669
134LCK0.42234745
135DYRK1A0.41429925
136SYK0.40021730
137ITK0.39751986
138BTK0.39670776
139CAMK40.39556746
140PRKG10.39333842
141TNIK0.38077310
142PRKCA0.36739291
143STK30.36410338
144FGFR20.36195571
145CHUK0.35670292
146VRK20.35566696
147ILK0.35241767
148GRK10.35183926
149ERBB20.35041961
150CSNK1A1L0.34465091
151NUAK10.34318558
152PLK10.33196486
153CHEK20.32866677
154RPS6KA60.32433860
155CDK30.32211948
156MAP2K40.31377930
157ZAK0.31176085
158KIT0.29621324
159ERBB30.29546892
160MARK30.29295464
161JAK30.28671563

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.39552100
2Oxidative phosphorylation_Homo sapiens_hsa001903.57300381
3Proteasome_Homo sapiens_hsa030503.14828487
4Protein export_Homo sapiens_hsa030602.96486924
5Parkinsons disease_Homo sapiens_hsa050122.92390103
6Graft-versus-host disease_Homo sapiens_hsa053322.86773993
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74121429
8Huntingtons disease_Homo sapiens_hsa050162.69780586
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.54730575
10Basal transcription factors_Homo sapiens_hsa030222.41288091
11Butanoate metabolism_Homo sapiens_hsa006502.34710888
12Caffeine metabolism_Homo sapiens_hsa002322.27320349
13RNA polymerase_Homo sapiens_hsa030202.26792888
14Alzheimers disease_Homo sapiens_hsa050102.21872584
15Homologous recombination_Homo sapiens_hsa034402.16262654
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10472152
17Nitrogen metabolism_Homo sapiens_hsa009102.09858222
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09640911
19Allograft rejection_Homo sapiens_hsa053302.05997741
20Selenocompound metabolism_Homo sapiens_hsa004502.04746485
21Nicotine addiction_Homo sapiens_hsa050332.04535308
22Fanconi anemia pathway_Homo sapiens_hsa034601.94875485
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92634817
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83215410
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74800767
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.73486511
27Olfactory transduction_Homo sapiens_hsa047401.66951582
28DNA replication_Homo sapiens_hsa030301.63494630
29Autoimmune thyroid disease_Homo sapiens_hsa053201.61746987
30Tryptophan metabolism_Homo sapiens_hsa003801.59719117
31Linoleic acid metabolism_Homo sapiens_hsa005911.57562785
32Taste transduction_Homo sapiens_hsa047421.54827730
33Arachidonic acid metabolism_Homo sapiens_hsa005901.52502530
34Pyrimidine metabolism_Homo sapiens_hsa002401.52024194
35Rheumatoid arthritis_Homo sapiens_hsa053231.48254568
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.45655314
37Cardiac muscle contraction_Homo sapiens_hsa042601.45598200
38Legionellosis_Homo sapiens_hsa051341.36353617
39Asthma_Homo sapiens_hsa053101.34443683
40Ether lipid metabolism_Homo sapiens_hsa005651.31875375
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31262094
42Chemical carcinogenesis_Homo sapiens_hsa052041.31013610
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.29392653
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28795323
45Spliceosome_Homo sapiens_hsa030401.26765348
46Morphine addiction_Homo sapiens_hsa050321.25167523
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23117412
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21485113
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20724347
50Measles_Homo sapiens_hsa051621.20474321
51Vitamin B6 metabolism_Homo sapiens_hsa007501.18575839
52Type I diabetes mellitus_Homo sapiens_hsa049401.16818530
53Nucleotide excision repair_Homo sapiens_hsa034201.16671926
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.13745473
55Propanoate metabolism_Homo sapiens_hsa006401.13635823
56Sphingolipid metabolism_Homo sapiens_hsa006001.13414547
57Retinol metabolism_Homo sapiens_hsa008301.12480348
58Purine metabolism_Homo sapiens_hsa002301.11576059
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09788955
60Mismatch repair_Homo sapiens_hsa034301.09181625
61NF-kappa B signaling pathway_Homo sapiens_hsa040641.08811947
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08141409
63Antigen processing and presentation_Homo sapiens_hsa046121.06823008
64Malaria_Homo sapiens_hsa051441.03279411
65Base excision repair_Homo sapiens_hsa034101.02665532
66GABAergic synapse_Homo sapiens_hsa047271.01499278
67Collecting duct acid secretion_Homo sapiens_hsa049661.01202719
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00910737
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00624848
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00013813
71Peroxisome_Homo sapiens_hsa041460.98343380
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98028131
73Circadian entrainment_Homo sapiens_hsa047130.97399097
74Leishmaniasis_Homo sapiens_hsa051400.97289294
75Herpes simplex infection_Homo sapiens_hsa051680.94419502
76Insulin secretion_Homo sapiens_hsa049110.94038252
77Serotonergic synapse_Homo sapiens_hsa047260.93428894
78Glutamatergic synapse_Homo sapiens_hsa047240.88406154
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84462784
80Hematopoietic cell lineage_Homo sapiens_hsa046400.83191790
81Fat digestion and absorption_Homo sapiens_hsa049750.82419410
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82217480
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81467771
84ABC transporters_Homo sapiens_hsa020100.80980206
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80670887
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80434307
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80182722
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80013724
89RNA degradation_Homo sapiens_hsa030180.79284289
90RNA transport_Homo sapiens_hsa030130.79141394
91Salmonella infection_Homo sapiens_hsa051320.77698107
92Pertussis_Homo sapiens_hsa051330.77079545
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76659681
94Phagosome_Homo sapiens_hsa041450.76464341
95beta-Alanine metabolism_Homo sapiens_hsa004100.76251245
96Glycerolipid metabolism_Homo sapiens_hsa005610.74250232
97Primary immunodeficiency_Homo sapiens_hsa053400.73363773
98Other glycan degradation_Homo sapiens_hsa005110.71276296
99Salivary secretion_Homo sapiens_hsa049700.71273223
100Ovarian steroidogenesis_Homo sapiens_hsa049130.70614829
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69760281
102Steroid biosynthesis_Homo sapiens_hsa001000.69627575
103Mineral absorption_Homo sapiens_hsa049780.67962767
104Vitamin digestion and absorption_Homo sapiens_hsa049770.63290909
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62660629
106Histidine metabolism_Homo sapiens_hsa003400.62620203
107Tuberculosis_Homo sapiens_hsa051520.61452026
108Influenza A_Homo sapiens_hsa051640.60666149
109Calcium signaling pathway_Homo sapiens_hsa040200.60580933
110Systemic lupus erythematosus_Homo sapiens_hsa053220.58531886
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58022271
112Pentose phosphate pathway_Homo sapiens_hsa000300.56718299
113Glutathione metabolism_Homo sapiens_hsa004800.56061003
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55698524
115One carbon pool by folate_Homo sapiens_hsa006700.55380470
116Vibrio cholerae infection_Homo sapiens_hsa051100.55346659
117Epstein-Barr virus infection_Homo sapiens_hsa051690.55295655
118African trypanosomiasis_Homo sapiens_hsa051430.53457742
119Circadian rhythm_Homo sapiens_hsa047100.53416754
120Non-homologous end-joining_Homo sapiens_hsa034500.51256158
121Sulfur relay system_Homo sapiens_hsa041220.50867567
122Cocaine addiction_Homo sapiens_hsa050300.47161326
123Amphetamine addiction_Homo sapiens_hsa050310.46494123
124Dopaminergic synapse_Homo sapiens_hsa047280.44365650
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.43769351
126Metabolic pathways_Homo sapiens_hsa011000.43187890
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.42079232
128Cell cycle_Homo sapiens_hsa041100.41696508
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.41619347
130Sulfur metabolism_Homo sapiens_hsa009200.41451235
131Regulation of autophagy_Homo sapiens_hsa041400.40799000
132Staphylococcus aureus infection_Homo sapiens_hsa051500.40735711
133Osteoclast differentiation_Homo sapiens_hsa043800.40453327
134Fatty acid degradation_Homo sapiens_hsa000710.40132400
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39896537
136Basal cell carcinoma_Homo sapiens_hsa052170.38220779
137mRNA surveillance pathway_Homo sapiens_hsa030150.37908391
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37797140
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36154489
140Fatty acid biosynthesis_Homo sapiens_hsa000610.35352603
141Arginine and proline metabolism_Homo sapiens_hsa003300.34771993
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32977803
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32207223
144Folate biosynthesis_Homo sapiens_hsa007900.31195083
145Oocyte meiosis_Homo sapiens_hsa041140.31138242
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30610448
147Hedgehog signaling pathway_Homo sapiens_hsa043400.29722166
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29375299
149Phototransduction_Homo sapiens_hsa047440.28782064
150Shigellosis_Homo sapiens_hsa051310.27868615
151T cell receptor signaling pathway_Homo sapiens_hsa046600.27363122
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26285414
153p53 signaling pathway_Homo sapiens_hsa041150.25848981
154Dorso-ventral axis formation_Homo sapiens_hsa043200.20860878

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