FAM222B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.34708922
2regulation of meiosis I (GO:0060631)4.09794788
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07938323
4regulation of gene silencing by RNA (GO:0060966)3.84398289
5regulation of posttranscriptional gene silencing (GO:0060147)3.84398289
6regulation of gene silencing by miRNA (GO:0060964)3.84398289
7male meiosis (GO:0007140)3.47473447
8regulation of meiosis (GO:0040020)3.45767235
9paraxial mesoderm development (GO:0048339)3.45726321
10DNA methylation involved in gamete generation (GO:0043046)3.44492578
11pre-miRNA processing (GO:0031054)3.43638143
12histone H4-K12 acetylation (GO:0043983)3.41947760
13chromatin remodeling at centromere (GO:0031055)3.32884151
14single strand break repair (GO:0000012)3.30014982
15innervation (GO:0060384)3.28147751
16negative regulation of gene silencing (GO:0060969)3.21623894
17positive regulation of meiosis (GO:0045836)3.20339517
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19897153
19layer formation in cerebral cortex (GO:0021819)3.18115446
20negative regulation of meiosis (GO:0045835)3.16081233
21positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.15746079
22chaperone-mediated protein transport (GO:0072321)3.14409171
23synaptic vesicle exocytosis (GO:0016079)3.10740259
24protein polyglutamylation (GO:0018095)3.08566919
25CENP-A containing nucleosome assembly (GO:0034080)3.07798246
26neuron cell-cell adhesion (GO:0007158)3.04601418
27auditory behavior (GO:0031223)3.01983007
28cell migration in hindbrain (GO:0021535)3.01803964
29regulation of NFAT protein import into nucleus (GO:0051532)3.01711658
30regulation of sister chromatid cohesion (GO:0007063)2.99234652
31notochord development (GO:0030903)2.99230406
32heterochromatin organization (GO:0070828)2.98985637
33DNA replication checkpoint (GO:0000076)2.98353597
34establishment of protein localization to mitochondrial membrane (GO:0090151)2.95876178
35ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.94906536
36histone exchange (GO:0043486)2.93632564
37synaptic vesicle endocytosis (GO:0048488)2.93470059
38rRNA modification (GO:0000154)2.90760088
39behavioral response to nicotine (GO:0035095)2.89471471
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88153604
41regulation of mitotic spindle checkpoint (GO:1903504)2.88153604
42gene silencing by RNA (GO:0031047)2.82404241
43positive regulation of meiotic cell cycle (GO:0051446)2.81025187
44body morphogenesis (GO:0010171)2.78514298
45rRNA methylation (GO:0031167)2.75569402
46regulation of meiotic cell cycle (GO:0051445)2.75015609
47regulation of DNA methylation (GO:0044030)2.72120357
48regulation of histone H3-K9 methylation (GO:0051570)2.72055691
49DNA replication-independent nucleosome organization (GO:0034724)2.71843621
50DNA replication-independent nucleosome assembly (GO:0006336)2.71843621
51phenol-containing compound catabolic process (GO:0019336)2.71788700
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70808307
53somite rostral/caudal axis specification (GO:0032525)2.70131022
54DNA damage response, detection of DNA damage (GO:0042769)2.68709488
55presynaptic membrane organization (GO:0097090)2.68627773
56resolution of meiotic recombination intermediates (GO:0000712)2.67679279
57synaptic vesicle maturation (GO:0016188)2.66372757
58female gamete generation (GO:0007292)2.66269331
59regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.65712270
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65425862
61substrate-independent telencephalic tangential migration (GO:0021826)2.65425862
62regulation of transforming growth factor beta2 production (GO:0032909)2.64421142
63regulation of nuclear cell cycle DNA replication (GO:0033262)2.64083089
64meiotic cell cycle (GO:0051321)2.61827112
65cell junction maintenance (GO:0034331)2.60726442
66positive regulation of sodium ion transmembrane transport (GO:1902307)2.59008723
67synaptonemal complex assembly (GO:0007130)2.58936556
68DNA methylation (GO:0006306)2.58273076
69DNA alkylation (GO:0006305)2.58273076
70regulation of clathrin-mediated endocytosis (GO:2000369)2.57464292
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.56540229
72termination of RNA polymerase III transcription (GO:0006386)2.56540229
73protein localization to kinetochore (GO:0034501)2.55821385
74neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.55820966
75stress granule assembly (GO:0034063)2.55608588
76DNA damage response, signal transduction resulting in transcription (GO:0042772)2.54932399
77ovulation cycle (GO:0042698)2.53564571
78mitotic sister chromatid cohesion (GO:0007064)2.52847412
79embryonic body morphogenesis (GO:0010172)2.51489597
80SMAD protein complex assembly (GO:0007183)2.50929637
81intracellular estrogen receptor signaling pathway (GO:0030520)2.50521591
82cell-cell junction maintenance (GO:0045217)2.49248457
83negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.49209846
84positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.49144113
85cAMP-mediated signaling (GO:0019933)2.49116838
86regulation of synaptic vesicle exocytosis (GO:2000300)2.48376984
87presynaptic membrane assembly (GO:0097105)2.47036066
88negative regulation of histone methylation (GO:0031061)2.46866320
89positive regulation of gastrulation (GO:2000543)2.46638334
90type B pancreatic cell development (GO:0003323)2.46584799
91cell communication by electrical coupling (GO:0010644)2.45704421
92kinetochore assembly (GO:0051382)2.45024558
93glucocorticoid receptor signaling pathway (GO:0042921)2.44581145
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.44399875
95mitotic metaphase plate congression (GO:0007080)2.44140567
96binding of sperm to zona pellucida (GO:0007339)2.43785722
97establishment of integrated proviral latency (GO:0075713)2.43311830
98histone H2A monoubiquitination (GO:0035518)2.41684591
99cochlea development (GO:0090102)2.41598608
100multicellular organism reproduction (GO:0032504)2.41137460
101synaptonemal complex organization (GO:0070193)2.41111869
102regulation of calcium ion-dependent exocytosis (GO:0017158)2.40930555
103negative regulation of translation, ncRNA-mediated (GO:0040033)2.39155383
104regulation of translation, ncRNA-mediated (GO:0045974)2.39155383
105negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39155383
106spermatid development (GO:0007286)2.39137136
107microtubule severing (GO:0051013)2.38682810
108histone H2A ubiquitination (GO:0033522)2.38183589
109negative regulation of microtubule polymerization (GO:0031115)2.37925564
110chemosensory behavior (GO:0007635)2.35926472
111nonmotile primary cilium assembly (GO:0035058)2.35835244
112mechanosensory behavior (GO:0007638)2.35449246
113chromosome organization involved in meiosis (GO:0070192)2.33746942
114regulation of glucocorticoid secretion (GO:2000849)2.33734771
115centriole replication (GO:0007099)2.33257632
116synapsis (GO:0007129)2.33215600
117histone arginine methylation (GO:0034969)2.33102459
118regulation of spindle checkpoint (GO:0090231)2.33086856
119snRNA transcription (GO:0009301)2.33049963
120protein neddylation (GO:0045116)2.32409801
121genetic imprinting (GO:0071514)2.31711703
122oogenesis (GO:0048477)2.31428944
123cerebellar Purkinje cell differentiation (GO:0021702)2.31426702
124regulation of early endosome to late endosome transport (GO:2000641)2.31390095
125acrosome reaction (GO:0007340)2.30790116
126protein localization to synapse (GO:0035418)2.30308673
127pyrimidine nucleobase catabolic process (GO:0006208)2.29528877
128proteasome assembly (GO:0043248)2.28939332
129male meiosis I (GO:0007141)2.28836869
130negative regulation of circadian rhythm (GO:0042754)2.27005820
131ATP-dependent chromatin remodeling (GO:0043044)2.26753807
132regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.26095289
133glutamate secretion (GO:0014047)2.25386449
134mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.25325663
135regulation of gene silencing (GO:0060968)2.23741436
136regulation of synaptic vesicle transport (GO:1902803)2.23390246
137corticosteroid receptor signaling pathway (GO:0031958)2.22904152
138RNA localization (GO:0006403)2.22810752
139startle response (GO:0001964)2.22587239
140primitive streak formation (GO:0090009)2.21374025
141regulation of corticosteroid hormone secretion (GO:2000846)2.21067333
142behavioral response to ethanol (GO:0048149)2.20624655
143sperm-egg recognition (GO:0035036)2.19896048
144negative regulation of smooth muscle cell differentiation (GO:0051151)2.19122478
145regulation of chromatin silencing (GO:0031935)2.18979949
146establishment of mitochondrion localization (GO:0051654)2.18926860
147DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.18323280
148postsynaptic membrane organization (GO:0001941)2.18197188
149regulation of stem cell maintenance (GO:2000036)2.18114005
150response to pheromone (GO:0019236)2.18029508
151nucleosome disassembly (GO:0006337)2.17678729
152protein-DNA complex disassembly (GO:0032986)2.17678729
153positive regulation of neurological system process (GO:0031646)2.17457055
154apical protein localization (GO:0045176)2.17065479
155neuromuscular process controlling posture (GO:0050884)2.16599025
156kinetochore organization (GO:0051383)2.16467505
157G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.16289998
158mitotic chromosome condensation (GO:0007076)2.15689340
159regulation of acrosome reaction (GO:0060046)2.15597444
160microtubule nucleation (GO:0007020)2.15251648
161response to auditory stimulus (GO:0010996)2.14924309
162histone H3-K4 methylation (GO:0051568)2.14076276
163regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.13491667
164mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.13291751
165protein localization to chromosome, centromeric region (GO:0071459)2.12969656
166axonal fasciculation (GO:0007413)2.12758087
167mitochondrion transport along microtubule (GO:0047497)2.12584515
168establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.12584515
169microtubule depolymerization (GO:0007019)2.12469499
170spliceosomal snRNP assembly (GO:0000387)2.11622685
171positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.11489099
172positive regulation of cell cycle G2/M phase transition (GO:1902751)2.11489099
173negative regulation of meiotic cell cycle (GO:0051447)2.11444020
174gastrulation with mouth forming second (GO:0001702)2.11305461
175thalamus development (GO:0021794)2.11151877
176DNA double-strand break processing (GO:0000729)2.06745184
177mitochondrial respiratory chain complex I assembly (GO:0032981)2.06516193
178NADH dehydrogenase complex assembly (GO:0010257)2.06516193
179mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.06516193
180negative regulation of transcription regulatory region DNA binding (GO:2000678)2.06380017
181meiotic cell cycle process (GO:1903046)2.06239522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24797584
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.39562161
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94840842
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87761841
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83911219
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.78783588
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.66439575
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24162736
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.22615792
10IGF1R_20145208_ChIP-Seq_DFB_Human2.17603881
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.16830406
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.14586202
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.12596491
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.09012756
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03738180
16E2F7_22180533_ChIP-Seq_HELA_Human1.99631201
17GBX2_23144817_ChIP-Seq_PC3_Human1.99309973
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96559172
19REST_21632747_ChIP-Seq_MESCs_Mouse1.92719131
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91126120
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.87617148
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.87617148
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.87617148
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86326526
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85510995
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84494755
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83784395
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83700299
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.83252001
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83200738
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82644879
32ZNF274_21170338_ChIP-Seq_K562_Hela1.77612132
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77554465
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.77179033
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73833612
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73023975
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70779579
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67977428
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66723945
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65525388
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.65143245
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63062543
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63062543
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.62756132
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.62295397
46RNF2_27304074_Chip-Seq_NSC_Mouse1.62258620
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61596631
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60508612
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59735225
50VDR_22108803_ChIP-Seq_LS180_Human1.57818909
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57298748
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55980221
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.55893884
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55709348
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54701410
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54188930
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53817576
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53544359
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.53363435
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53241291
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52192588
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.50759324
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49283018
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.49071817
65TTF2_22483619_ChIP-Seq_HELA_Human1.47972049
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44899768
67MYC_18940864_ChIP-ChIP_HL60_Human1.44441789
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44163028
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43219812
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41645069
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.41267915
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40687765
73SMAD4_21799915_ChIP-Seq_A2780_Human1.38934441
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38873101
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37677946
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.37339366
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36516808
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36301196
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.36051926
80FUS_26573619_Chip-Seq_HEK293_Human1.35941929
81AR_19668381_ChIP-Seq_PC3_Human1.34040445
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33454220
83IRF1_19129219_ChIP-ChIP_H3396_Human1.32596976
84STAT3_23295773_ChIP-Seq_U87_Human1.32312462
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32135013
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31191907
87PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30791278
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30499175
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30205147
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29318848
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26827667
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26218282
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24938205
94GABP_19822575_ChIP-Seq_HepG2_Human1.24444184
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24214087
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24122582
97XRN2_22483619_ChIP-Seq_HELA_Human1.23790657
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.23306463
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22644490
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21830255
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.21528337
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21472608
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.21087062
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19839158
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17965335
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17450928
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17308337
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14649728
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14484233
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.14211712
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13675300
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13509750
113FOXP3_21729870_ChIP-Seq_TREG_Human1.12238831
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11660203
115ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10575313
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10349269
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09390306
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.08976798
119TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08700361
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08571784
121KDM2B_26808549_Chip-Seq_K562_Human1.08433390
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08252356
123TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08099183
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07764929
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06992805
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06936341
127CBX2_27304074_Chip-Seq_ESCs_Mouse1.06646847
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06378121
129EZH2_27294783_Chip-Seq_ESCs_Mouse1.05118463
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04942775
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04333229
132ELK1_19687146_ChIP-ChIP_HELA_Human1.03639575
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03530790
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03496581
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03147035
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02822304
137P300_19829295_ChIP-Seq_ESCs_Human1.02807154
138PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01519919
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01279379
140TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01263654
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00927493
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00927493
143TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00741153
144ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00621678
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00430750
146E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99749912
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99512911
148EWS_26573619_Chip-Seq_HEK293_Human0.99193714
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97587871
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97256527
151SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96834123
152PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96617541
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96324781
154NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96265935
155SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95981004
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95366317
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95109900
158CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94685933
159RUNX2_22187159_ChIP-Seq_PCA_Human0.94636089
160GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91222076
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87923848
162NOTCH1_21737748_ChIP-Seq_TLL_Human0.84143470
163* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83962392
164PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83602483
165KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82108897
166TP53_22573176_ChIP-Seq_HFKS_Human0.81870040
167TAF15_26573619_Chip-Seq_HEK293_Human0.79494018
168SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79439478
169ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79432444
170SMAD3_21741376_ChIP-Seq_ESCs_Human0.79224972
171E2F1_21310950_ChIP-Seq_MCF-7_Human0.78906863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.49218114
2MP0003121_genomic_imprinting3.24611566
3MP0002653_abnormal_ependyma_morphology3.14915034
4MP0008877_abnormal_DNA_methylation3.07374685
5MP0003123_paternal_imprinting2.65085500
6MP0004859_abnormal_synaptic_plasticity2.36544695
7MP0003693_abnormal_embryo_hatching2.35792762
8MP0004270_analgesia2.33737235
9MP0003890_abnormal_embryonic-extraembry2.30820791
10MP0003787_abnormal_imprinting2.21359101
11MP0001188_hyperpigmentation2.00727895
12MP0001293_anophthalmia2.00537727
13MP0005423_abnormal_somatic_nervous1.96811295
14MP0001984_abnormal_olfaction1.93966734
15MP0010030_abnormal_orbit_morphology1.93698128
16MP0006276_abnormal_autonomic_nervous1.88549149
17MP0000778_abnormal_nervous_system1.82716293
18MP0005248_abnormal_Harderian_gland1.82169239
19MP0003880_abnormal_central_pattern1.77290466
20MP0008058_abnormal_DNA_repair1.73992383
21MP0006292_abnormal_olfactory_placode1.73927328
22MP0003635_abnormal_synaptic_transmissio1.72196779
23MP0003646_muscle_fatigue1.70206818
24MP0002063_abnormal_learning/memory/cond1.66777700
25MP0006072_abnormal_retinal_apoptosis1.64182942
26MP0002127_abnormal_cardiovascular_syste1.59190744
27MP0009379_abnormal_foot_pigmentation1.59057762
28MP0002822_catalepsy1.58000162
29MP0003136_yellow_coat_color1.56646404
30MP0003941_abnormal_skin_development1.56065512
31MP0002572_abnormal_emotion/affect_behav1.53556316
32MP0003329_amyloid_beta_deposits1.52148260
33MP0004957_abnormal_blastocyst_morpholog1.50847997
34MP0002184_abnormal_innervation1.47198560
35MP0003567_abnormal_fetal_cardiomyocyte1.46537715
36MP0005646_abnormal_pituitary_gland1.46226755
37MP0000631_abnormal_neuroendocrine_gland1.45412948
38MP0003861_abnormal_nervous_system1.44883687
39MP0008932_abnormal_embryonic_tissue1.40953558
40MP0005394_taste/olfaction_phenotype1.39004999
41MP0005499_abnormal_olfactory_system1.39004999
42MP0005410_abnormal_fertilization1.38067035
43MP0003119_abnormal_digestive_system1.37766566
44MP0002837_dystrophic_cardiac_calcinosis1.37174994
45MP0001929_abnormal_gametogenesis1.35770370
46MP0002938_white_spotting1.35580501
47MP0003718_maternal_effect1.32363010
48MP0003111_abnormal_nucleus_morphology1.32211033
49MP0003077_abnormal_cell_cycle1.31894333
50MP0002233_abnormal_nose_morphology1.30271053
51MP0002234_abnormal_pharynx_morphology1.29835601
52MP0002734_abnormal_mechanical_nocicepti1.29691828
53MP0002733_abnormal_thermal_nociception1.28597612
54MP0002638_abnormal_pupillary_reflex1.28499955
55MP0001529_abnormal_vocalization1.27567392
56MP0001486_abnormal_startle_reflex1.25145602
57MP0004264_abnormal_extraembryonic_tissu1.24850406
58MP0002152_abnormal_brain_morphology1.24090716
59MP0005076_abnormal_cell_differentiation1.22871466
60MP0001502_abnormal_circadian_rhythm1.22354128
61MP0002909_abnormal_adrenal_gland1.22022067
62MP0004133_heterotaxia1.20928159
63MP0008789_abnormal_olfactory_epithelium1.20425238
64MP0003698_abnormal_male_reproductive1.20261184
65MP0004233_abnormal_muscle_weight1.19759471
66MP0000955_abnormal_spinal_cord1.18062391
67MP0003011_delayed_dark_adaptation1.17569700
68MP0003942_abnormal_urinary_system1.16276781
69MP0004858_abnormal_nervous_system1.16029735
70MP0000566_synostosis1.15329977
71MP0008961_abnormal_basal_metabolism1.15154240
72MP0003755_abnormal_palate_morphology1.12749897
73MP0005551_abnormal_eye_electrophysiolog1.12672217
74MP0010094_abnormal_chromosome_stability1.10710150
75MP0002697_abnormal_eye_size1.10390384
76MP0002084_abnormal_developmental_patter1.09832384
77MP0002085_abnormal_embryonic_tissue1.08598965
78MP0002102_abnormal_ear_morphology1.07467963
79MP0002064_seizures1.07387799
80MP0002882_abnormal_neuron_morphology1.06287773
81MP0002557_abnormal_social/conspecific_i1.05532819
82MP0003938_abnormal_ear_development1.05356040
83MP0005379_endocrine/exocrine_gland_phen1.04994609
84MP0009672_abnormal_birth_weight1.03894730
85MP0001672_abnormal_embryogenesis/_devel1.03598813
86MP0005380_embryogenesis_phenotype1.03598813
87MP0003632_abnormal_nervous_system0.99870062
88MP0002735_abnormal_chemical_nociception0.99007149
89MP0008057_abnormal_DNA_replication0.98081447
90MP0005451_abnormal_body_composition0.97826665
91MP0009046_muscle_twitch0.97799895
92MP0000639_abnormal_adrenal_gland0.97795971
93MP0003935_abnormal_craniofacial_develop0.97570626
94MP0003937_abnormal_limbs/digits/tail_de0.97357173
95MP0010386_abnormal_urinary_bladder0.97339890
96MP0001697_abnormal_embryo_size0.97331995
97MP0005645_abnormal_hypothalamus_physiol0.97258887
98MP0001730_embryonic_growth_arrest0.96742726
99MP0005253_abnormal_eye_physiology0.96625379
100MP0002752_abnormal_somatic_nervous0.96516072
101MP0000049_abnormal_middle_ear0.96467626
102MP0002161_abnormal_fertility/fecundity0.96240367
103MP0003984_embryonic_growth_retardation0.95344881
104MP0001970_abnormal_pain_threshold0.94002304
105MP0002088_abnormal_embryonic_growth/wei0.91679800
106MP0004811_abnormal_neuron_physiology0.90266162
107MP0002751_abnormal_autonomic_nervous0.89819474
108MP0005187_abnormal_penis_morphology0.89196785
109MP0008995_early_reproductive_senescence0.87649772
110MP0002116_abnormal_craniofacial_bone0.87640933
111MP0004085_abnormal_heartbeat0.87381522
112MP0004142_abnormal_muscle_tone0.86411371
113MP0009745_abnormal_behavioral_response0.85987970
114MP0001968_abnormal_touch/_nociception0.85019006
115MP0002067_abnormal_sensory_capabilities0.84434184
116MP0002210_abnormal_sex_determination0.82731083
117MP0000653_abnormal_sex_gland0.82529670
118MP0002272_abnormal_nervous_system0.81651445
119MP0005377_hearing/vestibular/ear_phenot0.81066762
120MP0003878_abnormal_ear_physiology0.81066762
121MP0001905_abnormal_dopamine_level0.80125909
122MP0005395_other_phenotype0.80080287
123MP0009703_decreased_birth_body0.78989759
124MP0001286_abnormal_eye_development0.77882588
125MP0001485_abnormal_pinna_reflex0.77020607
126MP0001944_abnormal_pancreas_morphology0.76109138
127MP0003315_abnormal_perineum_morphology0.75970567
128MP0002925_abnormal_cardiovascular_devel0.75861459
129MP0005257_abnormal_intraocular_pressure0.75127870
130MP0001145_abnormal_male_reproductive0.74414500
131MP0000350_abnormal_cell_proliferation0.74028335
132MP0003137_abnormal_impulse_conducting0.73108846
133MP0002736_abnormal_nociception_after0.72952753
134MP0001299_abnormal_eye_distance/0.72592410
135MP0003699_abnormal_female_reproductive0.72019683
136MP0002111_abnormal_tail_morphology0.71765408
137MP0002081_perinatal_lethality0.71522314
138MP0000026_abnormal_inner_ear0.70779544
139MP0002160_abnormal_reproductive_system0.69374219

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.66243718
2Genetic anticipation (HP:0003743)3.57458297
3Papillary thyroid carcinoma (HP:0002895)3.53699574
4Abnormality of the labia minora (HP:0012880)3.40727077
5Facial hemangioma (HP:0000329)3.29163874
6Shawl scrotum (HP:0000049)3.01304976
7Adrenal hypoplasia (HP:0000835)2.79965442
8Bifid tongue (HP:0010297)2.79533245
9Limb dystonia (HP:0002451)2.75135504
10Absent septum pellucidum (HP:0001331)2.63147594
11Hepatoblastoma (HP:0002884)2.60897078
12Maternal diabetes (HP:0009800)2.49815841
13Progressive cerebellar ataxia (HP:0002073)2.48394390
14Atonic seizures (HP:0010819)2.47146197
15Hyperglycinemia (HP:0002154)2.45039775
16Optic nerve hypoplasia (HP:0000609)2.44933147
17Long eyelashes (HP:0000527)2.42248712
18Reticulocytopenia (HP:0001896)2.40722388
19Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39836492
20EEG with generalized epileptiform discharges (HP:0011198)2.35288861
21Oligodactyly (HP:0012165)2.35233254
22Abnormality of the aortic arch (HP:0012303)2.35114195
23Rib fusion (HP:0000902)2.33689051
24Failure to thrive in infancy (HP:0001531)2.32496143
25Aplasia/Hypoplasia of the sternum (HP:0006714)2.32174745
26Colon cancer (HP:0003003)2.30679082
27Epileptiform EEG discharges (HP:0011182)2.28857325
28Agitation (HP:0000713)2.27641683
29Facial cleft (HP:0002006)2.24979552
30Capillary hemangiomas (HP:0005306)2.23861728
31Hypsarrhythmia (HP:0002521)2.22953671
32Abnormal hair whorl (HP:0010721)2.21120062
33Thyroid carcinoma (HP:0002890)2.18811632
34Focal seizures (HP:0007359)2.17417438
35Anophthalmia (HP:0000528)2.16367680
36Amblyopia (HP:0000646)2.15325084
37Cortical dysplasia (HP:0002539)2.13755564
38Abnormality of the septum pellucidum (HP:0007375)2.13575955
39Supernumerary spleens (HP:0009799)2.13220057
40Abnormality of macular pigmentation (HP:0008002)2.11922050
41Abnormal lung lobation (HP:0002101)2.11627426
42Absence seizures (HP:0002121)2.07482972
43Absent speech (HP:0001344)2.07001806
44Impulsivity (HP:0100710)2.06879359
45Neoplasm of the adrenal cortex (HP:0100641)2.06834879
46Atelectasis (HP:0100750)2.05890120
47Epileptic encephalopathy (HP:0200134)2.04255138
48Genital tract atresia (HP:0001827)2.03689321
49Megalencephaly (HP:0001355)2.02533976
50Abnormality of the corticospinal tract (HP:0002492)1.99417116
51Vaginal atresia (HP:0000148)1.98755617
52Osteomalacia (HP:0002749)1.98243803
53Medial flaring of the eyebrow (HP:0010747)1.97891847
54Bilateral microphthalmos (HP:0007633)1.97166285
55Febrile seizures (HP:0002373)1.96082448
56Abnormality of the fingertips (HP:0001211)1.95903464
57Gait imbalance (HP:0002141)1.91160673
58Trigonocephaly (HP:0000243)1.90635109
59Growth hormone deficiency (HP:0000824)1.90019022
60Meckel diverticulum (HP:0002245)1.89009854
61Increased hepatocellular lipid droplets (HP:0006565)1.88645097
62Transitional cell carcinoma of the bladder (HP:0006740)1.88570601
63Leiomyosarcoma (HP:0100243)1.87292420
64Uterine leiomyosarcoma (HP:0002891)1.87292420
65Anencephaly (HP:0002323)1.86997763
66Abnormal number of erythroid precursors (HP:0012131)1.85356700
67Oligodactyly (hands) (HP:0001180)1.85033298
68Multiple enchondromatosis (HP:0005701)1.84210264
69Bladder neoplasm (HP:0009725)1.83624119
70Bladder carcinoma (HP:0002862)1.83624119
71Scrotal hypoplasia (HP:0000046)1.83028411
72Nephronophthisis (HP:0000090)1.82725005
73Urinary bladder sphincter dysfunction (HP:0002839)1.82563413
74Focal motor seizures (HP:0011153)1.82457741
75Macroorchidism (HP:0000053)1.82370086
76Dialeptic seizures (HP:0011146)1.82283792
77Preaxial hand polydactyly (HP:0001177)1.81909173
78Generalized tonic-clonic seizures (HP:0002069)1.81839400
79Acute necrotizing encephalopathy (HP:0006965)1.81698808
80Molar tooth sign on MRI (HP:0002419)1.81627849
81Abnormality of midbrain morphology (HP:0002418)1.81627849
82Abnormality of the ileum (HP:0001549)1.80003676
83Renal hypoplasia (HP:0000089)1.79303562
84Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.79052814
85Median cleft lip (HP:0000161)1.78771292
86Abnormality of cells of the erythroid lineage (HP:0012130)1.78481739
87Choanal stenosis (HP:0000452)1.78288393
88Patellar aplasia (HP:0006443)1.78117343
89Horseshoe kidney (HP:0000085)1.78058772
90Absent eyebrow (HP:0002223)1.77055933
91Volvulus (HP:0002580)1.77044965
92Insulin-resistant diabetes mellitus (HP:0000831)1.76325363
93Renal Fanconi syndrome (HP:0001994)1.75227230
94Abnormality of the phalanges of the hallux (HP:0010057)1.74922596
95Acute encephalopathy (HP:0006846)1.74903384
96High anterior hairline (HP:0009890)1.74836588
97Congenital primary aphakia (HP:0007707)1.74678551
98Scotoma (HP:0000575)1.74602299
99Atrophy/Degeneration involving motor neurons (HP:0007373)1.74216256
100Hyperglycinuria (HP:0003108)1.74029185
101Esophageal atresia (HP:0002032)1.73657580
102Myokymia (HP:0002411)1.73578641
103Partial duplication of thumb phalanx (HP:0009944)1.72812893
104Intestinal atresia (HP:0011100)1.72259480
105Polyphagia (HP:0002591)1.71980335
106Triphalangeal thumb (HP:0001199)1.71834872
107Aplasia/Hypoplasia of the patella (HP:0006498)1.71601793
108Nephrogenic diabetes insipidus (HP:0009806)1.70194650
109Visual hallucinations (HP:0002367)1.70109481
110Broad thumb (HP:0011304)1.69656043
111Lipid accumulation in hepatocytes (HP:0006561)1.69339089
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.68850817
113Ectopic kidney (HP:0000086)1.68779680
114Apathy (HP:0000741)1.68616719
115Chronic hepatic failure (HP:0100626)1.68359220
116Anterior segment dysgenesis (HP:0007700)1.67485814
117Sclerocornea (HP:0000647)1.67138391
118Birth length less than 3rd percentile (HP:0003561)1.67131414
119Abnormal number of incisors (HP:0011064)1.67036057
120Methylmalonic acidemia (HP:0002912)1.66940242
121Absent forearm bone (HP:0003953)1.66777596
122Aplasia involving forearm bones (HP:0009822)1.66777596
123Labial hypoplasia (HP:0000066)1.66755258
124Hemiparesis (HP:0001269)1.66075301
125Gastrointestinal atresia (HP:0002589)1.65522124
126Retinal dysplasia (HP:0007973)1.65432120
127Abnormality of the columella (HP:0009929)1.65066118
128Drooling (HP:0002307)1.64670674
129Excessive salivation (HP:0003781)1.64670674
130Truncus arteriosus (HP:0001660)1.63739083
131Poor speech (HP:0002465)1.63732559
132Myelomeningocele (HP:0002475)1.63543773
133Pancreatic fibrosis (HP:0100732)1.63321772
134Hypoplastic female external genitalia (HP:0012815)1.63058302
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.62956639
136Chromsome breakage (HP:0040012)1.62661133
137Midline defect of the nose (HP:0004122)1.62410591
138Amyotrophic lateral sclerosis (HP:0007354)1.60214046
139Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.60131380
140Short 1st metacarpal (HP:0010034)1.60131380
141Pancreatic cysts (HP:0001737)1.59667107
142Poor coordination (HP:0002370)1.59551854
143Spastic gait (HP:0002064)1.59478665
144Truncal obesity (HP:0001956)1.58750679
145Stenosis of the external auditory canal (HP:0000402)1.58483061
146Flat capital femoral epiphysis (HP:0003370)1.58242309
147Chorioretinal atrophy (HP:0000533)1.57995741
148Micropenis (HP:0000054)1.57591193
149Abnormality of the labia (HP:0000058)1.57388552
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.57108230
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57108230
152True hermaphroditism (HP:0010459)1.56879799
153Abnormality of abdominal situs (HP:0011620)1.55944101
154Abdominal situs inversus (HP:0003363)1.55944101
155Absent thumb (HP:0009777)1.55862119
156Pendular nystagmus (HP:0012043)1.55081093
157Hyperglycemia (HP:0003074)1.54381593
158Abnormality of glycine metabolism (HP:0010895)1.54340797
159Abnormality of serine family amino acid metabolism (HP:0010894)1.54340797
160Deep palmar crease (HP:0006191)1.54146212
161Cleft eyelid (HP:0000625)1.54145166
162Absent radius (HP:0003974)1.53877587
163Downturned corners of mouth (HP:0002714)1.53768413
164Narrow forehead (HP:0000341)1.53746096
165Broad toe (HP:0001837)1.53586253
166Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53339538
167Increased nuchal translucency (HP:0010880)1.53121632
168Bicornuate uterus (HP:0000813)1.52435697
169Abnormal pancreas size (HP:0012094)1.51813740
170Poor suck (HP:0002033)1.51496388
171Dandy-Walker malformation (HP:0001305)1.50727219
172Occipital encephalocele (HP:0002085)1.50197993
173Breast hypoplasia (HP:0003187)1.50197678
174Congenital stationary night blindness (HP:0007642)1.49858096
175Abnormality of the anterior horn cell (HP:0006802)1.49761884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.66273117
2MAP3K93.70071850
3LATS23.16432251
4MAP3K42.57127419
5VRK22.32429575
6NTRK22.30039840
7BUB12.27626379
8TAOK12.27032435
9LATS12.25942947
10TRIM282.23249047
11CASK2.12740112
12STK38L2.09269248
13MAP3K122.00213253
14NTRK31.93316629
15KSR21.88384054
16CAMK1D1.87083407
17CAMK1G1.85891560
18NUAK11.78050154
19SIK31.73041759
20MAP2K41.72176568
21KSR11.68970902
22EPHA41.63095038
23BMPR1B1.62236298
24NME11.59568324
25DYRK31.56092137
26ARAF1.51064535
27PRKD31.50901961
28PBK1.48561704
29MAP3K61.48138403
30ZAK1.40704530
31STK161.39555312
32CDC71.39307120
33INSRR1.38361146
34TAF11.37164455
35DYRK21.36513444
36MAPK131.36248682
37MARK11.35366293
38PINK11.35221605
39CDK191.34734104
40UHMK11.33840813
41MINK11.33797939
42PAK61.33617308
43PNCK1.33436891
44SRPK11.30791022
45BRAF1.30561633
46MAP2K71.30193788
47CHEK21.28348556
48MAP4K21.27826037
49TYRO31.26862653
50ERBB41.23175182
51BRD41.20994760
52PAK31.20906097
53PLK41.19592312
54TAOK31.15473303
55NTRK11.13600544
56TTK1.07449165
57ERN11.06508952
58MELK1.04107754
59PRKCG1.01217980
60DMPK0.97164797
61MUSK0.96732901
62WNK30.95242774
63MKNK20.92693744
64ACVR1B0.92512536
65AKT30.92435355
66MARK20.91572807
67BCKDK0.91244156
68TSSK60.90672783
69MAP3K50.89874935
70GRK50.88520452
71STK240.87917912
72FGFR20.83325722
73VRK10.82416017
74PHKG10.80637754
75PHKG20.80637754
76RAF10.80014797
77PLK20.75989496
78MKNK10.75741636
79MAP3K130.75740401
80CSNK1G20.75724538
81MOS0.75585487
82SGK20.74300817
83WNK40.73823257
84PRPF4B0.73714464
85MAPK100.73598068
86DYRK1A0.72764439
87TIE10.71840923
88PRKCI0.70709163
89MTOR0.70060876
90ICK0.70022620
91CSNK1G10.68167417
92WEE10.67883196
93ATR0.66749088
94STK380.66307367
95SGK4940.64861141
96SGK2230.64861141
97CDK80.64713820
98BRSK10.64109874
99CDK140.63691643
100STK110.63659159
101CDK180.63529055
102EPHB20.62949607
103CDC42BPA0.61535393
104ADRBK10.61377467
105PTK20.60838742
106CSNK1E0.59852543
107GRK10.58469653
108LIMK10.57071311
109PRKAA10.56719982
110BCR0.56691502
111PRKD20.56548036
112NEK10.56206703
113BRSK20.56026885
114CDK150.55497216
115CAMK40.54433184
116CSNK1G30.54405925
117AURKB0.54404982
118CDK70.54304445
119PAK40.53669602
120CAMK2A0.52407860
121CDK50.52155958
122STK30.52133860
123DYRK1B0.52113347
124TNIK0.51670186
125ATM0.50875889
126CDK20.49768998
127CSNK1A1L0.49428678
128CHEK10.49308752
129AURKA0.48781595
130PASK0.48439148
131GSK3B0.48083872
132FGFR10.47612831
133PLK10.47532309
134STK390.47010113
135CDK11A0.46874553
136CDK30.45967313
137PRKCZ0.45457494
138NEK20.44896724
139SIK20.44831643
140CDK10.44813595
141CAMK10.44621090
142MET0.43865937
143PLK30.40368309
144SGK30.39892268

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.41974666
2Mismatch repair_Homo sapiens_hsa034302.33462946
3Oxidative phosphorylation_Homo sapiens_hsa001902.22096296
4Nicotine addiction_Homo sapiens_hsa050332.21862959
5Dorso-ventral axis formation_Homo sapiens_hsa043202.09977396
6Parkinsons disease_Homo sapiens_hsa050122.09568372
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05390433
8Long-term potentiation_Homo sapiens_hsa047201.97961976
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90821727
10Insulin secretion_Homo sapiens_hsa049111.89263111
11Dopaminergic synapse_Homo sapiens_hsa047281.87390206
12Base excision repair_Homo sapiens_hsa034101.85015538
13Serotonergic synapse_Homo sapiens_hsa047261.83163757
14Synaptic vesicle cycle_Homo sapiens_hsa047211.82708607
15Oocyte meiosis_Homo sapiens_hsa041141.80189032
16GABAergic synapse_Homo sapiens_hsa047271.77399391
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76833686
18DNA replication_Homo sapiens_hsa030301.75701203
19Fanconi anemia pathway_Homo sapiens_hsa034601.74031708
20Spliceosome_Homo sapiens_hsa030401.72324158
21Proteasome_Homo sapiens_hsa030501.72284732
22Glutamatergic synapse_Homo sapiens_hsa047241.70868101
23Homologous recombination_Homo sapiens_hsa034401.64887832
24Circadian entrainment_Homo sapiens_hsa047131.64308732
25Olfactory transduction_Homo sapiens_hsa047401.63607217
26Phototransduction_Homo sapiens_hsa047441.61226158
27Steroid biosynthesis_Homo sapiens_hsa001001.59710185
28Protein export_Homo sapiens_hsa030601.57695712
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.56503550
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55325949
31Long-term depression_Homo sapiens_hsa047301.54329045
32Cocaine addiction_Homo sapiens_hsa050301.53443151
33Cell cycle_Homo sapiens_hsa041101.52264912
34Renal cell carcinoma_Homo sapiens_hsa052111.49714376
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49575651
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48388450
37GnRH signaling pathway_Homo sapiens_hsa049121.45101302
38Amphetamine addiction_Homo sapiens_hsa050311.44841397
39Circadian rhythm_Homo sapiens_hsa047101.43961351
40Vitamin B6 metabolism_Homo sapiens_hsa007501.41111788
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37879156
42Basal transcription factors_Homo sapiens_hsa030221.35821072
43Morphine addiction_Homo sapiens_hsa050321.34709849
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34477056
45Selenocompound metabolism_Homo sapiens_hsa004501.32585401
46Cholinergic synapse_Homo sapiens_hsa047251.31425645
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31399774
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30436123
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29485864
50mTOR signaling pathway_Homo sapiens_hsa041501.29139998
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26472340
52TGF-beta signaling pathway_Homo sapiens_hsa043501.24913557
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23993448
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.21231716
55Taste transduction_Homo sapiens_hsa047421.20753015
56ErbB signaling pathway_Homo sapiens_hsa040121.18040320
57Axon guidance_Homo sapiens_hsa043601.17525035
58Colorectal cancer_Homo sapiens_hsa052101.16858280
59Alzheimers disease_Homo sapiens_hsa050101.16826866
60Gap junction_Homo sapiens_hsa045401.16810701
61Adherens junction_Homo sapiens_hsa045201.15284485
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15045272
63Nucleotide excision repair_Homo sapiens_hsa034201.14734309
64Cardiac muscle contraction_Homo sapiens_hsa042601.13088434
65Melanogenesis_Homo sapiens_hsa049161.12980131
66Glioma_Homo sapiens_hsa052141.12247602
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11203013
68Estrogen signaling pathway_Homo sapiens_hsa049151.10869662
69Choline metabolism in cancer_Homo sapiens_hsa052311.09531054
70mRNA surveillance pathway_Homo sapiens_hsa030151.09296472
71cAMP signaling pathway_Homo sapiens_hsa040241.08933574
72Hippo signaling pathway_Homo sapiens_hsa043901.08874572
73Non-homologous end-joining_Homo sapiens_hsa034501.07978812
74Wnt signaling pathway_Homo sapiens_hsa043101.07579718
75MicroRNAs in cancer_Homo sapiens_hsa052061.07246798
76Ovarian steroidogenesis_Homo sapiens_hsa049131.07149942
77Pyrimidine metabolism_Homo sapiens_hsa002401.05138310
78Fatty acid elongation_Homo sapiens_hsa000621.02571832
79Oxytocin signaling pathway_Homo sapiens_hsa049211.02028606
80Ether lipid metabolism_Homo sapiens_hsa005651.01196562
81Type II diabetes mellitus_Homo sapiens_hsa049301.01146989
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00626399
83Pancreatic cancer_Homo sapiens_hsa052120.99859545
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99669908
85Endometrial cancer_Homo sapiens_hsa052130.99540217
86Hedgehog signaling pathway_Homo sapiens_hsa043400.99409863
87Dilated cardiomyopathy_Homo sapiens_hsa054140.96891638
88Propanoate metabolism_Homo sapiens_hsa006400.96730811
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96475536
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93536945
91Glucagon signaling pathway_Homo sapiens_hsa049220.93165867
92Purine metabolism_Homo sapiens_hsa002300.91821839
93Folate biosynthesis_Homo sapiens_hsa007900.91675869
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91128735
95RNA degradation_Homo sapiens_hsa030180.91107914
96Pyruvate metabolism_Homo sapiens_hsa006200.90336263
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.89608185
98Renin secretion_Homo sapiens_hsa049240.88067464
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85947858
100Collecting duct acid secretion_Homo sapiens_hsa049660.85759942
101Ras signaling pathway_Homo sapiens_hsa040140.85071952
102MAPK signaling pathway_Homo sapiens_hsa040100.85046935
103Basal cell carcinoma_Homo sapiens_hsa052170.84819718
104Notch signaling pathway_Homo sapiens_hsa043300.81478726
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.81239320
106Vibrio cholerae infection_Homo sapiens_hsa051100.80966407
107Lysine degradation_Homo sapiens_hsa003100.78833535
108RNA transport_Homo sapiens_hsa030130.78479352
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.78000214
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77651309
111Sulfur relay system_Homo sapiens_hsa041220.77388753
112VEGF signaling pathway_Homo sapiens_hsa043700.75657455
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74871870
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73170048
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72957992
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72346977
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68472247
118FoxO signaling pathway_Homo sapiens_hsa040680.68158078
119Huntingtons disease_Homo sapiens_hsa050160.68045364
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66931226
121Salivary secretion_Homo sapiens_hsa049700.66269205
122Arginine and proline metabolism_Homo sapiens_hsa003300.65526091
123Bladder cancer_Homo sapiens_hsa052190.65284257
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64002950
125Regulation of autophagy_Homo sapiens_hsa041400.62864594
126RNA polymerase_Homo sapiens_hsa030200.62783537
127Rap1 signaling pathway_Homo sapiens_hsa040150.61101410
128Vitamin digestion and absorption_Homo sapiens_hsa049770.60863791
129Tight junction_Homo sapiens_hsa045300.60231699
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.60178617
131Metabolic pathways_Homo sapiens_hsa011000.59782616
132p53 signaling pathway_Homo sapiens_hsa041150.59699639
133Butanoate metabolism_Homo sapiens_hsa006500.59456660
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59283449
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58079997
136Prostate cancer_Homo sapiens_hsa052150.58058175
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57188379
138Non-small cell lung cancer_Homo sapiens_hsa052230.57047151
139Biosynthesis of amino acids_Homo sapiens_hsa012300.56542713
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56230616
141Prion diseases_Homo sapiens_hsa050200.55491224
142One carbon pool by folate_Homo sapiens_hsa006700.54696245
143Insulin signaling pathway_Homo sapiens_hsa049100.54335738
144Gastric acid secretion_Homo sapiens_hsa049710.51709006
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50575537
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50338123
147Thyroid cancer_Homo sapiens_hsa052160.49041520
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48783382
149Fat digestion and absorption_Homo sapiens_hsa049750.42363427
150Fatty acid metabolism_Homo sapiens_hsa012120.40859356
151Caffeine metabolism_Homo sapiens_hsa002320.38135739
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34157231

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